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Aliases for PRAM1 Gene

Aliases for PRAM1 Gene

  • PML-RARA Regulated Adaptor Molecule 1 2 3 5
  • PRAM-1 3 4
  • PRAM 3 4
  • PML-RARA Target Gene Encoding An Adaptor Molecule-1 3
  • PML-RAR 3

External Ids for PRAM1 Gene

Previous GeneCards Identifiers for PRAM1 Gene

  • GC19M008461
  • GC19M008210
  • GC19M008554

Summaries for PRAM1 Gene

Entrez Gene Summary for PRAM1 Gene

  • The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRAM1 Gene

PRAM1 (PML-RARA Regulated Adaptor Molecule 1) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is FYB.

UniProtKB/Swiss-Prot for PRAM1 Gene

  • May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.

Gene Wiki entry for PRAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAM1 Gene

Genomics for PRAM1 Gene

Regulatory Elements for PRAM1 Gene

Promoters for PRAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRAM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRAM1 Gene

Chromosome:
19
Start:
8,490,055 bp from pter
End:
8,503,112 bp from pter
Size:
13,058 bases
Orientation:
Minus strand

Genomic View for PRAM1 Gene

Genes around PRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAM1 Gene

Proteins for PRAM1 Gene

  • Protein details for PRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QH2-PRAM_HUMAN
    Recommended name:
    PML-RARA-regulated adapter molecule 1
    Protein Accession:
    Q96QH2
    Secondary Accessions:
    • Q8N6W7

    Protein attributes for PRAM1 Gene

    Size:
    718 amino acids
    Molecular mass:
    79245 Da
    Quaternary structure:
    • Interacts with SKAP2, LCP2 and DBNL. May interact with LYN. Interacts with NEK6.

    Alternative splice isoforms for PRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRAM1 Gene

Proteomics data for PRAM1 Gene at MOPED

Post-translational modifications for PRAM1 Gene

Other Protein References for PRAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PRAM1 Gene

Domains & Families for PRAM1 Gene

Protein Domains for PRAM1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QH2

UniProtKB/Swiss-Prot:

PRAM_HUMAN :
  • The SH3 domain binds to PtdIns(4)P.
Domain:
  • The SH3 domain binds to PtdIns(4)P.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with PRAM1: view

No data available for Gene Families for PRAM1 Gene

Function for PRAM1 Gene

Molecular function for PRAM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
UniProtKB/Swiss-Prot Induction:
Down-regulated by the PML-RARA oncogene, a fusion protein expressed in a vast majority of acute promyelocytic leukemia. Up-regulated by retinoic acid or arsenic trioxide in cells expressing PML-RARA.

Gene Ontology (GO) - Molecular Function for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
genes like me logo Genes that share ontologies with PRAM1: view
genes like me logo Genes that share phenotypes with PRAM1: view

Animal Models for PRAM1 Gene

MGI Knock Outs for PRAM1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRAM1 Gene

Localization for PRAM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRAM1 Gene COMPARTMENTS Subcellular localization image for PRAM1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAM1 Gene

Pathways & Interactions for PRAM1 Gene

SuperPathways for PRAM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRAM1 Gene

Drugs & Compounds for PRAM1 Gene

No Compound Related Data Available

Transcripts for PRAM1 Gene

Unigene Clusters for PRAM1 Gene

PML-RARA regulated adaptor molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRAM1 Gene

No ASD Table

Relevant External Links for PRAM1 Gene

GeneLoc Exon Structure for
PRAM1
ECgene alternative splicing isoforms for
PRAM1

Expression for PRAM1 Gene

mRNA expression in normal human tissues for PRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAM1 Gene

This gene is overexpressed in Whole Blood (x29.6).

Protein differential expression in normal tissues from HIPED for PRAM1 Gene

This gene is overexpressed in Monocytes (40.7) and Peripheral blood mononuclear cells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRAM1 Gene



SOURCE GeneReport for Unigene cluster for PRAM1 Gene Hs.465812

mRNA Expression by UniProt/SwissProt for PRAM1 Gene

Q96QH2-PRAM_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung.
genes like me logo Genes that share expression patterns with PRAM1: view

Protein tissue co-expression partners for PRAM1 Gene

Primer Products

In Situ Assay Products

Orthologs for PRAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRAM1 35
  • 74.83 (n)
  • 66.25 (a)
PRAM1 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRAM1 35
  • 78.46 (n)
  • 70.75 (a)
PRAM1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pram1 35
  • 72.35 (n)
  • 64.43 (a)
Pram1 16
Pram1 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRAM1 35
  • 99.12 (n)
  • 98.76 (a)
PRAM1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pram1 35
  • 67.31 (n)
  • 59.16 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU855733.1 36
  • 29 (a)
OneToOne
Species with no ortholog for PRAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRAM1 Gene

ENSEMBL:
Gene Tree for PRAM1 (if available)
TreeFam:
Gene Tree for PRAM1 (if available)

Paralogs for PRAM1 Gene

Paralogs for PRAM1 Gene

(1) SIMAP similar genes for PRAM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRAM1: view

Variants for PRAM1 Gene

Sequence variations from dbSNP and Humsavar for PRAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs4804305 - 8,499,639(+) CTTCT(G/T)GGGGT reference, missense
rs4239541 - 8,499,590(+) CAGGC(A/G/T)GCGGG reference, missense
rs4239540 - 8,499,582(+) AGTGA(A/C)CTCAG reference, missense
rs58466313 - 8,499,404(+) TGGCC(C/T)CCAGC reference, missense
rs751180 -- 8,492,870(-) ATGGG(C/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAM1 Gene

Variant ID Type Subtype PubMed ID
nsv911004 CNV Loss 21882294
dgv3720n71 CNV Loss 21882294
dgv3721n71 CNV Loss 21882294
nsv458350 CNV Loss 19166990
dgv396n27 CNV Loss 19166990
nsv137944 CNV Insertion 16902084
dgv3722n71 CNV Loss 21882294
dgv3723n71 CNV Loss 21882294

Variation tolerance for PRAM1 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRAM1 Gene

HapMap Linkage Disequilibrium report
PRAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAM1 Gene

Disorders for PRAM1 Gene

Relevant External Links for PRAM1

Genetic Association Database (GAD)
PRAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAM1

No disorders were found for PRAM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAM1 Gene

Publications for PRAM1 Gene

  1. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. (PMID: 11301322) Moog-Lutz C. … Koretzky G. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. PRAM-1 is required for optimal integrin-dependent neutrophil function. (PMID: 15572693) Clemens R.A. … Peterson E.J. (Mol. Cell. Biol. 2004) 2 3
  3. Development and Validation of a 3-Plex RT-qPCR Assay for the Simultaneous Detection and Quantitation of the Three PML-RARa Fusion Transcripts in Acute Promyelocytic Leukemia. (PMID: 25815789) Chen Z. … Xia Z. (PLoS ONE 2015) 3
  4. MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia. (PMID: 25126724) Zeng C.W. … Chen Y.Q. (Autophagy 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PRAM1 Gene

Sources for PRAM1 Gene

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