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Aliases for PRAM1 Gene

Aliases for PRAM1 Gene

  • PML-RARA Regulated Adaptor Molecule 1 2 3 5
  • PRAM-1 3 4
  • PRAM 3 4
  • PML-RARA Target Gene Encoding An Adaptor Molecule-1 3
  • PML-RARA-Regulated Adapter Molecule 1 3
  • PML-RAR 3

External Ids for PRAM1 Gene

Previous GeneCards Identifiers for PRAM1 Gene

  • GC19M008461
  • GC19M008210
  • GC19M008554

Summaries for PRAM1 Gene

Entrez Gene Summary for PRAM1 Gene

  • The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRAM1 Gene

PRAM1 (PML-RARA Regulated Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with PRAM1 include Leukemia, Acute Promyelocytic, Somatic and Leukemia, Acute Myeloid. GO annotations related to this gene include lipid binding. An important paralog of this gene is FYB.

UniProtKB/Swiss-Prot for PRAM1 Gene

  • May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.

Gene Wiki entry for PRAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAM1 Gene

Genomics for PRAM1 Gene

Regulatory Elements for PRAM1 Gene

Enhancers for PRAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F008468 0.5 ENCODE 21.3 +34.3 34275 1.2 PAF1 FOXP2 PRAM1 MARCH2 GC19P008487 ENSG00000279827
GH19F008453 0.3 FANTOM5 20.7 +49.2 49175 0.2 PRDM10 PRAM1 ENSG00000279827 GC19P008487
GH19F008469 0.2 ENCODE 19 +32.8 32811 1.0 ZNF600 MAFK PRAM1 GC19P008487 ENSG00000279827
GH19F008472 0.9 Ensembl ENCODE 18.4 +29.5 29519 2.6 BCOR KLF1 PKNOX1 ZMYM3 ZNF664 POLR2A EED PRDM10 CREM MTA2 MARCH2 PRAM1 GC19P008487 ENSG00000279827
GH19F008451 1.1 ENCODE 17.3 +51.1 51085 1.6 HDAC1 INSM2 FEZF1 ZNF2 GATA2 ZNF366 SCRT2 USF2 ZEB2 SMARCA4 MARCH2 PRAM1 ENSG00000279827 GC19P008487
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRAM1 on UCSC Golden Path with GeneCards custom track

Promoters for PRAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001815859 712 801 BCOR SMARCA5 NR2F1 ZMYM3 HMBOX1 NR2F6 KDM1A HES1
ENSR00001815858 1412 201

Genomic Location for PRAM1 Gene

Chromosome:
19
Start:
8,490,055 bp from pter
End:
8,503,112 bp from pter
Size:
13,058 bases
Orientation:
Minus strand

Genomic View for PRAM1 Gene

Genes around PRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAM1 Gene

Proteins for PRAM1 Gene

  • Protein details for PRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QH2-PRAM_HUMAN
    Recommended name:
    PML-RARA-regulated adapter molecule 1
    Protein Accession:
    Q96QH2
    Secondary Accessions:
    • Q8N6W7

    Protein attributes for PRAM1 Gene

    Size:
    718 amino acids
    Molecular mass:
    79245 Da
    Quaternary structure:
    • Interacts with SKAP2, LCP2 and DBNL. May interact with LYN. Interacts with NEK6.

    Alternative splice isoforms for PRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRAM1 Gene

Post-translational modifications for PRAM1 Gene

Other Protein References for PRAM1 Gene

No data available for DME Specific Peptides for PRAM1 Gene

Domains & Families for PRAM1 Gene

Protein Domains for PRAM1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QH2

UniProtKB/Swiss-Prot:

PRAM_HUMAN :
  • The SH3 domain binds to PtdIns(4)P.
Domain:
  • The SH3 domain binds to PtdIns(4)P.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with PRAM1: view

No data available for Gene Families for PRAM1 Gene

Function for PRAM1 Gene

Molecular function for PRAM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
UniProtKB/Swiss-Prot Induction:
Down-regulated by the PML-RARA oncogene, a fusion protein expressed in a vast majority of acute promyelocytic leukemia. Up-regulated by retinoic acid or arsenic trioxide in cells expressing PML-RARA.

Gene Ontology (GO) - Molecular Function for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PRAM1: view
genes like me logo Genes that share phenotypes with PRAM1: view

Animal Models for PRAM1 Gene

MGI Knock Outs for PRAM1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRAM1 Gene

Localization for PRAM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRAM1 Gene COMPARTMENTS Subcellular localization image for PRAM1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAM1 Gene

Pathways & Interactions for PRAM1 Gene

SuperPathways for PRAM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007229 integrin-mediated signaling pathway IBA --
GO:0043313 regulation of neutrophil degranulation IEA,IBA --
genes like me logo Genes that share ontologies with PRAM1: view

No data available for Pathways by source and SIGNOR curated interactions for PRAM1 Gene

Transcripts for PRAM1 Gene

Unigene Clusters for PRAM1 Gene

PML-RARA regulated adaptor molecule 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAM1 Gene

No ASD Table

Relevant External Links for PRAM1 Gene

GeneLoc Exon Structure for
PRAM1
ECgene alternative splicing isoforms for
PRAM1

Expression for PRAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAM1 Gene

This gene is overexpressed in Whole Blood (x29.6).

Protein differential expression in normal tissues from HIPED for PRAM1 Gene

This gene is overexpressed in Monocytes (40.7) and Peripheral blood mononuclear cells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRAM1 Gene



Protein tissue co-expression partners for PRAM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRAM1 Gene:

PRAM1

SOURCE GeneReport for Unigene cluster for PRAM1 Gene:

Hs.465812

mRNA Expression by UniProt/SwissProt for PRAM1 Gene:

Q96QH2-PRAM_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung.
genes like me logo Genes that share expression patterns with PRAM1: view

Primer Products

Orthologs for PRAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRAM1 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia PRAM1 34 35
  • 78.46 (n)
cow
(Bos Taurus)
Mammalia PRAM1 34 35
  • 74.83 (n)
mouse
(Mus musculus)
Mammalia Pram1 34 16 35
  • 72.35 (n)
rat
(Rattus norvegicus)
Mammalia Pram1 34
  • 67.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU855733.1 35
  • 29 (a)
OneToOne
Species where no ortholog for PRAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRAM1 Gene

ENSEMBL:
Gene Tree for PRAM1 (if available)
TreeFam:
Gene Tree for PRAM1 (if available)

Paralogs for PRAM1 Gene

Paralogs for PRAM1 Gene

(1) SIMAP similar genes for PRAM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRAM1: view

Variants for PRAM1 Gene

Sequence variations from dbSNP and Humsavar for PRAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403336 -- 8,501,996(+) AGAAA(C/T)GTGTG intron-variant, upstream-variant-2KB
rs10407216 -- 8,500,205(+) gggct(C/T)caatg intron-variant, utr-variant-5-prime
rs10416007 -- 8,494,173(+) GGAAC(A/C)ATGGG intron-variant
rs10421050 -- 8,492,048(+) tccct(C/T)aacct intron-variant
rs10424009 -- 8,490,557(+) GCGGC(A/G)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAM1 Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
nsv137944 CNV insertion 16902084
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781

Variation tolerance for PRAM1 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAM1 Gene

Disorders for PRAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRAM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PRAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRAM1

Genetic Association Database (GAD)
PRAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAM1
genes like me logo Genes that share disorders with PRAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAM1 Gene

Publications for PRAM1 Gene

  1. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. (PMID: 11301322) Moog-Lutz C. … Koretzky G. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3 4 64
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  4. Lipid-binding hSH3 domains in immune cell adapter proteins. (PMID: 16831444) Heuer K. … Freund C. (J. Mol. Biol. 2006) 3 4 64
  5. PRAM-1 potentiates arsenic trioxide-induced JNK activation. (PMID: 15637062) Denis F.M. … Lutz P.G. (J. Biol. Chem. 2005) 3 4 64

Products for PRAM1 Gene

Sources for PRAM1 Gene

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