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Aliases for PRAG1 Gene

Aliases for PRAG1 Gene

  • PEAK1 Related, Kinase-Activating Pseudokinase 1 2 3
  • Sugen Kinase 223 2 3 4
  • Pragmin, RND2 Effector Protein 2 3
  • PEAK Family Member 2 2 3
  • SGK223 3 4
  • PEAK1-Related Kinase-Activating Pseudokinase 1 4
  • PEAK1 Related Kinase Activating Pseudokinase 1 5
  • Tyrosine-Protein Kinase SgK223 3
  • Homolog Of Rat Pragma Of Rnd2 3
  • Tyrosine-Protein Kinase PRAG1 3
  • EC 2.7.10.2 4
  • PRAGMIN 3
  • PEAK2 3
  • NACK 3

External Ids for PRAG1 Gene

Summaries for PRAG1 Gene

Entrez Gene Summary for PRAG1 Gene

  • This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]

GeneCards Summary for PRAG1 Gene

PRAG1 (PEAK1 Related, Kinase-Activating Pseudokinase 1) is a Protein Coding gene. An important paralog of this gene is PEAK1.

Additional gene information for PRAG1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAG1 Gene

Genomics for PRAG1 Gene

Regulatory Elements for PRAG1 Gene

Enhancers for PRAG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H008460 0.8 ENCODE 38.2 -75.3 -75333 2.4 SOX13 PKNOX1 FOXA2 RAD21 ZSCAN9 TEAD3 CTBP1 GATA3 ATF7 TCF7L2 PRAG1 FAM86B3P ENSG00000254153 PIR34264
GH08H009146 1.6 Ensembl ENCODE dbSUPER 12.2 -763.2 -763155 6.4 HDGF FOXA2 PKNOX1 SIN3A ZNF2 YY1 ZNF143 FOS SP3 REST FAM86B3P LOC101929128 ERI1 PRAG1 RPL10P19 PPP1R3B ENSG00000254340
GH08H008465 1 ENCODE 14.4 -80.7 -80682 2.8 FOXA2 ATF1 MLX ARID4B DMAP1 SLC30A9 SP5 MXD4 MIER2 PPARG ENSG00000254153 PRAG1 FAM86B3P PIR34264
GH08H009099 1.5 Ensembl ENCODE dbSUPER 9.3 -716.9 -716932 7.5 PKNOX1 FOXA2 ATF1 MLX ZFP64 FEZF1 YY1 TCF12 FOS SP5 FAM86B3P ERI1 RNU7-55P ENSG00000254340 PPP1R3B ENSG00000253426 PRAG1 RPL10P19 ENSG00000197334
GH08H008751 1.4 FANTOM5 Ensembl ENCODE 9.2 -366.9 -366879 2.9 PKNOX1 TBL1XR1 SIN3A ZBTB40 BATF ATF7 ETV6 RUNX3 IKZF2 CREM FAM86B3P MFHAS1 CLDN23 RPL10P19 ENSG00000207244 RNU7-55P PRAG1 ENSG00000254367 ENSG00000284717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRAG1 on UCSC Golden Path with GeneCards custom track

Promoters for PRAG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000220730 798 3001 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ETS1 GTF3C2 ZNF121 GLIS2

Genomic Locations for PRAG1 Gene

Genomic Locations for PRAG1 Gene
chr8:8,317,736-8,386,498
(GRCh38/hg38)
Size:
68,763 bases
Orientation:
Minus strand
chr8:8,175,258-8,244,008
(GRCh37/hg19)

Genomic View for PRAG1 Gene

Genes around PRAG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAG1 Gene

Proteins for PRAG1 Gene

  • Protein details for PRAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YV5-PRAG1_HUMAN
    Recommended name:
    Tyrosine-protein kinase PRAG1
    Protein Accession:
    Q86YV5
    Secondary Accessions:
    • Q8N3N5

    Protein attributes for PRAG1 Gene

    Size:
    1406 amino acids
    Molecular mass:
    149624 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAG1 Gene

Post-translational modifications for PRAG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAG1 Gene

No data available for DME Specific Peptides for PRAG1 Gene

Domains & Families for PRAG1 Gene

Gene Families for PRAG1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRAG1 Gene

Suggested Antigen Peptide Sequences for PRAG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YV5

UniProtKB/Swiss-Prot:

PRAG1_HUMAN :
  • Belongs to the protein kinase superfamily.
Family:
  • Belongs to the protein kinase superfamily.
genes like me logo Genes that share domains with PRAG1: view

Function for PRAG1 Gene

Molecular function for PRAG1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme Numbers (IUBMB) for PRAG1 Gene

Phenotypes From GWAS Catalog for PRAG1 Gene

Gene Ontology (GO) - Molecular Function for PRAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PRAG1: view
genes like me logo Genes that share phenotypes with PRAG1: view

Animal Models for PRAG1 Gene

MGI Knock Outs for PRAG1:

Animal Model Products

miRNA for PRAG1 Gene

miRTarBase miRNAs that target PRAG1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRAG1 Gene

Localization for PRAG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAG1 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAG1 Gene

Pathways & Interactions for PRAG1 Gene

SuperPathways for PRAG1 Gene

No Data Available

Interacting Proteins for PRAG1 Gene

Gene Ontology (GO) - Biological Process for PRAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with PRAG1: view

No data available for Pathways by source and SIGNOR curated interactions for PRAG1 Gene

Drugs & Compounds for PRAG1 Gene

No Compound Related Data Available

Transcripts for PRAG1 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAG1 Gene

No ASD Table

Relevant External Links for PRAG1 Gene

GeneLoc Exon Structure for
PRAG1
ECgene alternative splicing isoforms for
PRAG1

Expression for PRAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Evidence on tissue expression from TISSUES for PRAG1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with PRAG1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAG1 Gene

Orthologs for PRAG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472692 33
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia LOC482885 33
  • 84.14 (n)
cow
(Bos Taurus)
Mammalia LOC533821 33
  • 83.35 (n)
mouse
(Mus musculus)
Mammalia D8Ertd82e 33
  • 80.07 (n)
Prag1 16
rat
(Rattus norvegicus)
Mammalia Pragmin 33
  • 79.35 (n)
chicken
(Gallus gallus)
Aves SGK223 33
  • 60.55 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486686 33
  • 55.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398552 33
Species where no ortholog for PRAG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAG1 Gene

ENSEMBL:
Gene Tree for PRAG1 (if available)
TreeFam:
Gene Tree for PRAG1 (if available)

Paralogs for PRAG1 Gene

Paralogs for PRAG1 Gene

genes like me logo Genes that share paralogs with PRAG1: view

Variants for PRAG1 Gene

Sequence variations from dbSNP and Humsavar for PRAG1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000028544 -- 8,372,439(+) CTTAT(A/T)TTGGG intron-variant
rs1000039024 -- 8,383,741(+) CAAAT(A/C)CACCC intron-variant, upstream-variant-2KB
rs1000042836 -- 8,329,124(+) GCGGC(A/G)GCTCA intron-variant
rs1000081880 -- 8,372,685(+) AACAC(A/G/T)AATGG intron-variant
rs1000095643 -- 8,341,581(+) AATGC(A/C)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAG1 Gene

Variant ID Type Subtype PubMed ID
nsv831227 CNV gain+loss 17160897
nsv610157 CNV loss 21841781
nsv610156 CNV loss 21841781
nsv610154 CNV loss 21841781
nsv610153 CNV loss 21841781
nsv610152 CNV gain 21841781
nsv478031 CNV novel sequence insertion 20440878
nsv396756 CNV deletion 16902084
esv3616132 CNV loss 21293372
esv33394 CNV loss 17666407
esv3310316 CNV mobile element insertion 20981092
esv3303302 CNV mobile element insertion 20981092
esv2764098 CNV gain+loss 21179565
esv2759589 CNV gain+loss 17122850

Variation tolerance for PRAG1 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.84; 99.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRAG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAG1 Gene

Disorders for PRAG1 Gene

Relevant External Links for PRAG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAG1

No disorders were found for PRAG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAG1 Gene

Publications for PRAG1 Gene

  1. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. (PMID: 25038227) Weaver KL … Capobianco AJ (Cancer research 2014) 2 3 60
  2. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. (PMID: 21873224) Safari F … Hatakeyama M (Proceedings of the National Academy of Sciences of the United States of America 2011) 2 3 60
  3. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. (PMID: 16481321) Tanaka H … Negishi M (The Journal of biological chemistry 2006) 2 3 60
  4. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 60
  5. Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases. (PMID: 27531744) Liu L … Daly RJ (The Journal of biological chemistry 2016) 3 60

Products for PRAG1 Gene

Sources for PRAG1 Gene

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