Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRAF2 Gene

Aliases for PRAF2 Gene

  • PRA1 Domain Family, Member 2 2 3
  • JM4 3 6
  • PRA1 Family Protein 2 3
  • PRA1 Domain Family 2 2
  • Jena-Muenchen 4 3

External Ids for PRAF2 Gene

Previous GeneCards Identifiers for PRAF2 Gene

  • GC0XM048685
  • GC0XM048815
  • GC0XM048928
  • GC0XM046585

Summaries for PRAF2 Gene

GeneCards Summary for PRAF2 Gene

PRAF2 (PRA1 Domain Family, Member 2) is a Protein Coding gene. An important paralog of this gene is ARL6IP5.

UniProtKB/Swiss-Prot for PRAF2 Gene

  • May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAF2 Gene

Genomics for PRAF2 Gene

Regulatory Elements for PRAF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRAF2 Gene

49,071,156 bp from pter
49,074,071 bp from pter
2,916 bases
Minus strand

Genomic View for PRAF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAF2 Gene

Proteins for PRAF2 Gene

  • Protein details for PRAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRA1 family protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RD20

    Protein attributes for PRAF2 Gene

    178 amino acids
    Molecular mass:
    19258 Da
    Quaternary structure:
    • Interacts with CCR5 and GDE1.

neXtProt entry for PRAF2 Gene

Proteomics data for PRAF2 Gene at MOPED

Post-translational modifications for PRAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PRAF2 Gene

Domains for PRAF2 Gene

Protein Domains for PRAF2 Gene


Suggested Antigen Peptide Sequences for PRAF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O60831
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with PRAF2: view

No data available for Gene Families for PRAF2 Gene

Function for PRAF2 Gene

Molecular function for PRAF2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.

Phenotypes for PRAF2 Gene

genes like me logo Genes that share phenotypes with PRAF2: view

Animal Model Products

CRISPR Products

miRNA for PRAF2 Gene

miRTarBase miRNAs that target PRAF2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRAF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRAF2 Gene

Localization for PRAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAF2 Gene

Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PRAF2 Gene COMPARTMENTS Subcellular localization image for PRAF2 gene
Compartment Confidence
endosome 5
plasma membrane 3
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0010008 endosome membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRAF2: view

Pathways for PRAF2 Gene

SuperPathways for PRAF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0015813 L-glutamate transport ISS --
genes like me logo Genes that share ontologies with PRAF2: view

No data available for Pathways by source for PRAF2 Gene

Transcripts for PRAF2 Gene

mRNA/cDNA for PRAF2 Gene

Unigene Clusters for PRAF2 Gene

PRA1 domain family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRAF2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAF2 Gene

No ASD Table

Relevant External Links for PRAF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRAF2 Gene

mRNA expression in normal human tissues for PRAF2 Gene

Protein differential expression in normal tissues for PRAF2 Gene

This gene is overexpressed in Nasal epithelium (8.5) and Fetal testis (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PRAF2 Gene

SOURCE GeneReport for Unigene cluster for PRAF2 Gene Hs.29595

mRNA Expression by UniProt/SwissProt for PRAF2 Gene

Tissue specificity: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles.
genes like me logo Genes that share expressions with PRAF2: view

Expression partners for PRAF2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRAF2 Gene

Orthologs for PRAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRAF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRAF2 35
  • 90.82 (n)
  • 94.38 (a)
PRAF2 36
  • 94 (a)
(Canis familiaris)
Mammalia PRAF2 35
  • 89.89 (n)
  • 94.38 (a)
PRAF2 36
  • 94 (a)
(Mus musculus)
Mammalia Praf2 35
  • 86.7 (n)
  • 91.01 (a)
Praf2 16
Praf2 36
  • 91 (a)
(Pan troglodytes)
Mammalia PRAF2 35
  • 99.44 (n)
  • 99.44 (a)
(Rattus norvegicus)
Mammalia Praf2 35
  • 87.27 (n)
  • 91.57 (a)
(Anolis carolinensis)
Reptilia PRAF2 36
  • 66 (a)
(Danio rerio)
Actinopterygii praf2 35
  • 58.8 (n)
  • 58.43 (a)
praf2 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Jwa 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea praf-3 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9659 36
  • 43 (a)
Species with no ortholog for PRAF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRAF2 Gene

Gene Tree for PRAF2 (if available)
Gene Tree for PRAF2 (if available)

Paralogs for PRAF2 Gene

Paralogs for PRAF2 Gene

Selected SIMAP similar genes for PRAF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRAF2: view

Variants for PRAF2 Gene

Sequence variations from dbSNP and Humsavar for PRAF2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1802957 -- 49,071,510(-) CCTGG(A/G)GCAAG utr-variant-3-prime
rs6609827 -- 49,073,715(+) GCACC(C/T)CCCTC intron-variant
rs11554005 -- 49,072,454(-) GCTTC(A/G)GCATC reference, missense
rs34565429 - 49,073,822(-) TCGGC(C/T)TCGCT reference, missense
rs34823858 -- 49,072,081(-) CAATT(-/C)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAF2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Relevant External Links for PRAF2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAF2 Gene

Disorders for PRAF2 Gene

No disorders were found for PRAF2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PRAF2 Gene

Publications for PRAF2 Gene

  1. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo C.S. … Bachmann A.S. (Gene 2006) 2 3 4 23
  2. Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles. (PMID: 18395978) Koomoa D.-L. … Bachmann A.S. (Neurosci. Lett. 2008) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PMID: 15757671) Schweneker M. … Moelling K. (FEBS Lett. 2005) 3 4

Products for PRAF2 Gene

Sources for PRAF2 Gene

Back to Top