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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRAF2 Gene

protein-coding GIFtS: 52
GCID: GC0XM048928

PRA1 Domain Family, Member 2

(Previous name: PRA1 domain family 2)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
PRA1 Domain Family, Member 2¹ ²
PRA1 Domain Family 2¹
Jena-Muenchen 4²
PRA1 Family Protein 2²

External Ids:	HGNC: 28911¹	Entrez Gene: 11230²	Ensembl: ENSG00000243279⁷	OMIM: 300840⁵	UniProtKB: O60831³

Export aliases for PRAF2 gene to outside databases

Previous GC identifers: GC0XM048685 GC0XM048815 GC0XM046585

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PRAF2 Gene:

PRAF2 (PRA1 domain family, member 2) is a protein-coding gene. Diseases associated with PRAF2 include malignant glioma, and neuroblastoma. An important paralog of this gene is ARL6IP5.

UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831

Function: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in

cerulenin-induced neuroblastoma apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.2 NT_079573.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRAF2 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 Tal-1beta E47 CREB E2F-1 E2F PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRAF2 promoter sequence

Search SABiosciences Chromatin IP Primers for PRAF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

PRAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRAF2 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM048928: view genomic region (about GC identifiers)

Start:	48,928,813 bp from pter	End:	48,931,730 bp from pter
Size:	2,918 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831 (See protein sequence)

Recommended Name: PRA1 family protein 2

Size: 178 amino acids; 19258 Da

Subunit: Interacts with CCR5 and GDE1

Subcellular location: Endosome membrane; Multi-pass membrane protein (Probable)

Secondary accessions: B2RD20

Explore the universe of human proteins at neXtProt for PRAF2: NX_O60831

Explore proteomics data for PRAF2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_O60831

PRAF2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_009144.1

ENSEMBL proteins:

ENSP00000365570 ENSP00000365566

Human Recombinant Protein Products for PRAF2:

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	Novus Biologicals PRAF2 Protein Novus Biologicals PRAF2 Lysate
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	Cloud-Clone Corp. Proteins for PRAF2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010008	endosome membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

PRAF2 for ontologies About GeneDecksing

PRAF2 Antibody Products:

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Assay Products for PRAF2:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for PRAF2
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	Cloud-Clone Corp. ELISAs for PRAF2 Cloud-Clone Corp. CLIAs for PRAF2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR004895 Prenylated_rab_accept_PRA1

Graphical View of Domain Structure for InterPro Entry O60831

ProtoNet protein and cluster: O60831

UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831

Similarity: Belongs to the PRA1 family

PRAF2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PRAF2_HUMAN, O60831

Function: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in

cerulenin-induced neuroblastoma apoptosis

Phenotypes:
2 GenomeRNAi human phenotypes for PRAF2:

Decreased cilium length

Decreased cilium length after

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for PRAF2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRAF2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRAF2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRAF2

miRNA Products:		miRTarBase miRNAs that target PRAF2: hsa-mir-155 (MIRT001516)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRAF2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate PRAF2:
		hsa-miR-1321 hsa-miR-182 hsa-miR-3199 hsa-miR-631 hsa-miR-330-5p hsa-miR-326 hsa-miR-3661 hsa-miR-744*

		SwitchGear 3'UTR luciferase reporter plasmid: PRAF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PRAF2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PRAF2
		Search LifeMap BioReagents cell lines for PRAF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAF2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRAF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/10 Interacting proteins for PRAF2 (O60831^{2, 3} ENSP00000365570⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARL6IP5	O75915²^,³, ENSP00000273258⁴	MINT-58206 MINT-58200 MINT-58205 MINT-58202 I2D: score=3 STRING: ENSP00000273258
CCR5	P51681²^,³, ENSP00000292303⁴	MINT-58198 MINT-58199 MINT-58207 I2D: score=2 STRING: ENSP00000292303
PLIN3	O60664²^,³, ENSP00000221957⁴	MINT-58203 I2D: score=1 STRING: ENSP00000221957
CANX	P27824²^,³, ENSP00000247461⁴	MINT-58201 I2D: score=1 STRING: ENSP00000247461
RHOB	P62745³, ENSP00000272233⁴	I2D: score=1 STRING: ENSP00000272233

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	IEA	--
GO:0015813	L-glutamate transport	ISS	--

PRAF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRAF2

Search CenterWatch for drugs/clinical trials and news about PRAF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRAF2 gene:

NM_007213.2

Unigene Cluster for PRAF2:

PRA1 domain family, member 2

Hs.29595 [show with all ESTs]

Unigene Representative Sequence: BF982837

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376390(uc004dmi.3) ENST00000491199 ENST00000376386

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRAF2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate PRAF2:
		hsa-miR-1321 hsa-miR-182 hsa-miR-3199 hsa-miR-631 hsa-miR-330-5p hsa-miR-326 hsa-miR-3661 hsa-miR-744*

		SwitchGear 3'UTR luciferase reporter plasmid: PRAF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PRAF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRAF2

Clone Products:		OriGene clones in human, mouse for PRAF2 (see all 8) OriGene ORF clones in mouse, rat for PRAF2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PRAF2 (NM_007213)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRAF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAF2
		Sirion Biotech Customized lentivirus for stable overexpression of PRAF2 Customized lentivirus expression plasmids for stable overexpression of PRAF2

Primer Products:		OriGene qPCR primer pairs and template standards for PRAF2 OriGene qSTAR qPCR primer pairs in human, mouse for PRAF2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PRAF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRAF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAF2

Additional mRNA sequence:

AJ005896.1 AK023433.1 AK310550.1 AK315374.1 BC021213.2 CR457023.1

6 DOTS entries:

DT.87016785 DT.100796043 DT.95126895 DT.40249386 DT.121290065 DT.40110915

24/247 AceView cDNA sequences (see all 247):

AI360781 BU727938 BQ961376 BQ070006 CR607931 BQ674893 BM684565 BQ054846

AI741751 BU194666 BM552522 AI366690 CR597667 AI760476 CB155577 CB133307

BE302873 BF437713 BE300549 BM544778 BM801598 BM669757 CB136816 BQ056366

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRAF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCCCTGTGTG

About this image

See PRAF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRAF2

SOURCE GeneReport for Unigene cluster: Hs.29595

UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831

Tissue specificity: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in

tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same

patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in

cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in

non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles

SABiosciences Custom PCR Arrays for PRAF2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAF2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRAF2 gene from 5/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Praf2^{1 , 5}	PRA1 domain family 2^{1, 5}	86.7(n)¹ 91.01(a)¹		X (3.48 cM)⁵ 54637¹ NM_138602.4¹ NP_613068.1¹ 7728439⁵
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	66(a)	1 → many	GL343326.1(808765-819129)
zebrafish (Danio rerio)	Actinopterygii	praf2¹	PRA1 domain family, member 2	58.8(n) 58.43(a)		550393 NM_001017698.1 NP_001017698.1
fruit fly (Drosophila melanogaster)	Insecta	Jwa⁶	Jwa ortholog	28(a)	1 → many	2L(18704570-18705699)
worm (Caenorhabditis elegans)	Secernentea	praf-3⁶	Protein PRAF-3, isoform a	28(a)	1 → many	IV(8379990-8381916)

ENSEMBL Gene Tree for PRAF2 (if available)
TreeFam Gene Tree for PRAF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRAF2 gene

ARL6IP5²

2 SIMAP similar genes for PRAF2 using alignment to 2 protein entries: PRAF2_HUMAN (see all proteins):

WDR45 ARL6IP5

PRAF2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113084117^1,2	C,F	--	48928423(+)	`TGGCAC/TAATCA`	1	--	ds500¹		2		WA CSA	3
rs184665149^1,2		--	48928532(+)	`TTTAAA/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs188733095^1,2		--	48928707(+)	`AAGGGC/TCTCAG`	1	--	ds500¹		0	--	--	--	--
rs181515254^1,2		--	48928917(+)	`TTGTCC/GATGGT`	1	--	ut3¹		0	--	--	--	--
rs1802957^1,2	C,F	--	48929167(-)	`CCTGGG/AGCAAG`	1	--	ut3¹		2		WA CSA	3
rs144972607^1,2	C	--	48929302(+)	`GTCCTA/GGGTTC`	1	--	ut3¹		0	--	--	--	--
rs41309731^1,2	C	--	48929392(+)	`AGGGCA/GGTCAC`	1	--	ut3¹		0	--	--	--	--
rs185904234^1,2		--	48929562(+)	`GTGCCA/TCTAGT`	2	E V	mis¹		0	--	--	--	--
rs149181231^1,2	C,F	--	48929614(+)	`CTTGTT/GCTCAA`	2	/N /H	mis¹		1		NA	4544
rs143345164^1,2	C	--	48929620(+)	`CTCAAT/GCTTGT`	2	/I /L	mis¹		1		NA	4546

HapMap Linkage Disequilibrium report for PRAF2 (48928813 - 48931730 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for PRAF2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv528292	CNV	Gain	19592680
esv32909	CNV	Gain+Loss	17666407

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing PRAF2

DNA2.0 Custom Variant and Variant Library Synthesis for PRAF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 300840 OMIM disorders: --

4 diseases for PRAF2: About MalaCards

malignant glioma neuroblastoma cerebritis neuronitis

PRAF2 for disorders About GeneDecksing

Export disorders for PRAF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRAF2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with PRAF2)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PubMed id 16481131)^{1, 2, 3, 9} Fo C.S.... Bachmann A.S. (2006)
Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles. (PubMed id 18395978)^{1, 2, 9} Koomoa D.-L.... Bachmann A.S. (2008)
Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation. (PubMed id 17975142)^{1, 2} Geerts D.... Bachmann A.S. (2007)
JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PubMed id 15757671)^{1, 2} Schweneker M.... Moelling K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma. (PubMed id 23440329)¹ Yco L.P....Bachmann A.S. (2013)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration. (PubMed id 20412121)¹ Borsics T....Bachmann A.S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11230	HGNC: 28911	AceView: PRAF2	Ensembl:ENSG00000243279	euGenes: HUgn11230
ECgene: PRAF2	H-InvDB: PRAF2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRAF2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRAF2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRAF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PRAF2 gene:
Search GeneIP for patents involving PRAF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for PRAF2
	OriGene qPCR primer pairs and template standards for PRAF2		OriGene Protein Over-expression Lysate for PRAF2
	OriGene MassSpec something-or-other for PRAF2		OriGene clones in human, mouse for PRAF2
	OriGene qSTAR qPCR primer pairs in human, mouse for PRAF2		OriGene Purified Protein for PRAF2
	OriGene ORF clones in mouse, rat for PRAF2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PRAF2		OriGene Custom Protein Services for PRAF2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRAF2
	QIAGEN SeqTarget long-range PCR primers for resequencing PRAF2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAF2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRAF2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAF2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRAF2

	GenScript Custom Purified and Recombinant Proteins Services for PRAF2		GenScript cDNA clones with any tag delivered in your preferred vector for PRAF2
	GenScript Custom Assay Services for PRAF2		GenScript Custom Superior Antibodies Services for PRAF2
	GenScript Custom overexpressing Cell Line Services for PRAF2		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Search LifeMap BioReagents cell lines for PRAF2

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAF2

	SwitchGear 3'UTR luciferase reporter plasmids for PRAF2
	SwitchGear Promoter luciferase reporter plasmids for PRAF2

ThermoFisher Antibodies for PRAF2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAF2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for PRAF2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRAF2

Customized:

	lentivirus for stable overexpression of PRAF2
	lentivirus expression plasmids for stable overexpression of PRAF2
	adenovirus for overexpression of PRAF2

LSBio Antibodies in human, mouse, rat for PRAF2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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PRAF2 Gene

PRA1 Domain Family, Member 2

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PRAF2 Gene

PRA1 Domain Family, Member 2

Aliasesfor PRAF2 gene

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Genomic Viewsfor PRAF2 gene

Proteinsfor PRAF2 gene

Protein Domains /Familiesfor PRAF2 gene

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for PRAF2 gene

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for PRAF2 gene

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for PRAF2 gene

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Families
for PRAF2 gene

Function
for PRAF2 gene

Pathways & Interactions
for PRAF2 gene

Drugs & Compounds
for PRAF2 gene

Transcripts
for PRAF2 gene

Expression
for PRAF2 gene

Orthologs
for PRAF2 gene

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for PRAF2 gene

Genomic Variants
for PRAF2 gene

Disorders / Diseases
for PRAF2 gene

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for PRAF2 gene

Intellectual Property
for PRAF2 gene

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for PRAF2 gene