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Aliases for PRAF2 Gene

Aliases for PRAF2 Gene

  • PRA1 Domain Family Member 2 2 3 5
  • PRA1 Domain Family, Member 2 2 3
  • PRA1 Domain Family 2 2
  • Jena-Muenchen 4 3
  • Yip6a 3
  • JM4 3

External Ids for PRAF2 Gene

Previous GeneCards Identifiers for PRAF2 Gene

  • GC0XM048685
  • GC0XM048815
  • GC0XM048928
  • GC0XM046585

Summaries for PRAF2 Gene

GeneCards Summary for PRAF2 Gene

PRAF2 (PRA1 Domain Family Member 2) is a Protein Coding gene. Diseases associated with PRAF2 include Neuroblastoma. An important paralog of this gene is ARL6IP5.

UniProtKB/Swiss-Prot for PRAF2 Gene

  • May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAF2 Gene

Genomics for PRAF2 Gene

Regulatory Elements for PRAF2 Gene

Enhancers for PRAF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRAF2 on UCSC Golden Path with GeneCards custom track

Promoters for PRAF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRAF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRAF2 Gene

Chromosome:
X
Start:
49,071,156 bp from pter
End:
49,074,071 bp from pter
Size:
2,916 bases
Orientation:
Minus strand

Genomic View for PRAF2 Gene

Genes around PRAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAF2 Gene

Proteins for PRAF2 Gene

  • Protein details for PRAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60831-PRAF2_HUMAN
    Recommended name:
    PRA1 family protein 2
    Protein Accession:
    O60831
    Secondary Accessions:
    • B2RD20

    Protein attributes for PRAF2 Gene

    Size:
    178 amino acids
    Molecular mass:
    19258 Da
    Quaternary structure:
    • Interacts with CCR5 and GDE1.

neXtProt entry for PRAF2 Gene

Proteomics data for PRAF2 Gene at MOPED

Post-translational modifications for PRAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for JM4

No data available for DME Specific Peptides for PRAF2 Gene

Domains & Families for PRAF2 Gene

Gene Families for PRAF2 Gene

Protein Domains for PRAF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRAF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60831

UniProtKB/Swiss-Prot:

PRAF2_HUMAN :
  • Belongs to the PRA1 family.
Family:
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with PRAF2: view

Function for PRAF2 Gene

Molecular function for PRAF2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.

Phenotypes for PRAF2 Gene

genes like me logo Genes that share phenotypes with PRAF2: view

Animal Models for PRAF2 Gene

MGI Knock Outs for PRAF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRAF2

CRISPR Products

miRNA for PRAF2 Gene

miRTarBase miRNAs that target PRAF2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRAF2 Gene

Localization for PRAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAF2 Gene

Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRAF2 Gene COMPARTMENTS Subcellular localization image for PRAF2 gene
Compartment Confidence
endosome 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with PRAF2: view

Pathways & Interactions for PRAF2 Gene

SuperPathways for PRAF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAF2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRAF2 Gene

Drugs & Compounds for PRAF2 Gene

No Compound Related Data Available

Transcripts for PRAF2 Gene

mRNA/cDNA for PRAF2 Gene

Unigene Clusters for PRAF2 Gene

PRA1 domain family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRAF2 Gene

No ASD Table

Relevant External Links for PRAF2 Gene

GeneLoc Exon Structure for
PRAF2
ECgene alternative splicing isoforms for
PRAF2

Expression for PRAF2 Gene

mRNA expression in normal human tissues for PRAF2 Gene

Protein differential expression in normal tissues from HIPED for PRAF2 Gene

This gene is overexpressed in Nasal epithelium (8.5) and Fetal testis (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PRAF2 Gene



SOURCE GeneReport for Unigene cluster for PRAF2 Gene Hs.29595

mRNA Expression by UniProt/SwissProt for PRAF2 Gene

O60831-PRAF2_HUMAN
Tissue specificity: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles.
genes like me logo Genes that share expression patterns with PRAF2: view

Protein tissue co-expression partners for PRAF2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRAF2 Gene

Orthologs for PRAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRAF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRAF2 35
  • 90.82 (n)
  • 94.38 (a)
PRAF2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRAF2 35
  • 89.89 (n)
  • 94.38 (a)
PRAF2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Praf2 35
  • 86.7 (n)
  • 91.01 (a)
Praf2 16
Praf2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRAF2 35
  • 99.44 (n)
  • 99.44 (a)
rat
(Rattus norvegicus)
Mammalia Praf2 35
  • 87.27 (n)
  • 91.57 (a)
lizard
(Anolis carolinensis)
Reptilia PRAF2 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii praf2 35
  • 58.8 (n)
  • 58.43 (a)
praf2 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Jwa 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea praf-3 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9659 36
  • 43 (a)
OneToMany
Species with no ortholog for PRAF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRAF2 Gene

ENSEMBL:
Gene Tree for PRAF2 (if available)
TreeFam:
Gene Tree for PRAF2 (if available)

Paralogs for PRAF2 Gene

Paralogs for PRAF2 Gene

(2) SIMAP similar genes for PRAF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRAF2: view

Variants for PRAF2 Gene

Sequence variations from dbSNP and Humsavar for PRAF2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs34565429 - 49,073,822(-) TCGGC(C/T)TCGCT reference, missense
rs1802957 -- 49,071,510(-) CCTGG(A/G)GCAAG utr-variant-3-prime
rs6609827 -- 49,073,715(+) GCACC(C/T)CCCTC intron-variant
rs11554005 -- 49,072,454(-) GCTTC(A/G)GCATC reference, missense
rs34823858 -- 49,072,081(-) CAATT(-/C)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAF2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Variation tolerance for PRAF2 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRAF2 Gene

Disorders for PRAF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRAF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search PRAF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRAF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAF2
genes like me logo Genes that share disorders with PRAF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAF2 Gene

Publications for PRAF2 Gene

  1. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo C.S. … Bachmann A.S. (Gene 2006) 2 3 4 23 67
  2. Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles. (PMID: 18395978) Koomoa D.-L. … Bachmann A.S. (Neurosci. Lett. 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma. (PMID: 23440329) Yco L.P. … Bachmann A.S. (Int. J. Oncol. 2013) 3

Products for PRAF2 Gene

Sources for PRAF2 Gene

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