PRAF2 Gene
protein-coding GIFtS: 49
GCID: GC0XM048928
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PRA1 domain family, member 2(Previous name: PRA1 domain family 2 )
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Aliases
for PRAF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PRA1 Domain Family, Member 21 2 | | PRA1 Domain Family 21 2 | | JM41 | | Jena-Muenchen 42 | | PRA1 Family Protein 22 |
Export aliases for PRAF2 gene to outside databasesPrevious GC identifers: GC0XM048685 GC0XM048815 GC0XM046585 |
Summaries
for PRAF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Function: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-inducedneuroblastoma apoptosis
|
Genomic Views
for PRAF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRAF2 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 Tal-1beta E47 CREB E2F-1 E2F PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRAF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23PRAF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM048928: view genomic region
(about GC identifiers)
Start:
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48,928,818 bp from pter |
End:
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48,931,733 bp from pter |
Size:
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2,916 bases |
Orientation:
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minus strand |
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Proteins
for PRAF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831 (See
protein sequence)Recommended Name: PRA1 family protein 2 Size: 178 amino acids; 19258 Da
Subunit: Interacts with CCR5 and GDE1
Subcellular location: Endosome membrane; Multi-pass membrane protein (Probable)
Secondary accessions: B2RD20Explore the universe of human proteins at neXtProt for PRAF2: NX_O60831
PRAF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009144.1
ENSEMBL proteins: ENSP00000365570 ENSP00000365566
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010008 | endosome membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
PRAF2 for ontologies About GeneDecksing
PRAF2 Antibody Products:
Assay Products for PRAF2: |
Protein
Domains /
Families
for PRAF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRAF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60831ProtoNet protein and cluster: O60831 UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Similarity: Belongs to the PRA1 family |
Function
for PRAF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Function: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-inducedneuroblastoma apoptosis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAF2 |
2 GenomeRNAi human phenotypes for PRAF2:
|
Pathways & Interactions
for PRAF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRAF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/10 Interacting proteins for PRAF2 (O608312, 3 ENSP000003655704) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0015813 | L-glutamate transport |
ISS | -- |
PRAF2 for ontologies About GeneDecksing
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Drugs & Compounds
for PRAF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRAF2
Search CenterWatch for drugs/clinical trials and news about PRAF2
|
Transcripts
for PRAF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRAF2 gene: NM_007213.1 Unigene Cluster for PRAF2: PRA1 domain family, member 2 Hs.29595 [show with all ESTs]Unigene Representative Sequence: BF9828373 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376390(uc004dmi.3) ENST00000491199 ENST00000376386
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRAF2 (NM_007213) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRAF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAF2 |
Additional cDNA sequence: AJ005896.1 AK023433.1 AK310550.1 AK315374.1 BC021213.2 CR457023.1 6 DOTS entries: DT.87016785 DT.100796043 DT.95126895 DT.40249386 DT.121290065 DT.40110915 24/247 AceView cDNA sequences (see all 247): AI279534 AI560435 BQ674893 BU194666 CB155577 BQ672022 BI820498 BM699099 CR597667 CD518846 BC021213 BE391049 BQ051986 AI962235 BM684565 BM552522 AI360915 CF127497 AW327921 AU107631 BF057770 CB141564 AI184439 BQ943415
GeneLoc Exon Structure
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Expression
for PRAF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRAF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCTGTGTG
About this image
See PRAF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRAF2
SOURCE GeneReport for Unigene cluster: Hs.29595
UniProtKB/Swiss-Prot: PRAF2_HUMAN, O60831Tissue specificity: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumortissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. Highexpression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecularand the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebralcortex, hippocampus, and lateral ventricles
SABiosciences Custom PCR Arrays for PRAF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRAF2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAF2 |
Orthologs
for PRAF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PRAF2 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PRAF26 |
-- |
66(a) |
1 ↔ 1 |
GL343326.1(808765-819129) |
zebrafish
(Danio rerio) |
Actinopterygii |
praf21 |
PRA1 domain family, member 2 |
58.8(n)
58.43(a) |
|
550393 NM_001017698.1 NP_001017698.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Jwa6 |
Jwa ortholog |
28(a) |
1 → many |
2L(18704570-18705699) |
worm
(Caenorhabditis elegans) |
Secernentea |
praf-36 |
Prenylated Rab Acceptor 1 domain Family family mem... |
28(a) |
1 → many |
IV(8379977-8381903) |
ENSEMBL Gene Tree for PRAF2 (if available)
TreeFam Gene Tree for PRAF2 (if available) |
Paralogs
for PRAF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRAF2 gene
- ARL6IP52 ENSG000002502322
2 SIMAP similar genes for PRAF2 using alignment to 2 protein entries: PRAF2_HUMAN (see all proteins):WDR45 ARL6IP5
PRAF2 for paralogs About GeneDecksing
|
Genomic Variants
for PRAF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRAF2 (48928818 - 48931733 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PRAF2
1 CNV: 7789 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRAF2 |
|
Disorders
/ Diseases
for PRAF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRAF2 for disorders About GeneDecksing
OMIM gene information: 300840
OMIM disorders: --
4  diseases for PRAF2: About MalaCardsmalignant glioma cerebritis neuroblastoma neuronitis
Export disorders for PRAF2 gene to outside databases
|
Publications
for PRAF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRAF2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with PRAF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PubMed id 16481131)1, 2, 3, 9 Fo C.S.... Bachmann A.S. (2006)
- Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles. (PubMed id 18395978)1, 2, 9 Koomoa D.-L.... Bachmann A.S. (2008)
- Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation. (PubMed id 17975142)1, 2 Geerts D.... Bachmann A.S. (2007)
- JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PubMed id 15757671)1, 2 Schweneker M.... Moelling K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration. (PubMed id 20412121)1 Borsics T....Bachmann A.S. (2010)
- Praf2 is a novel Bcl-xL/Bcl-2 interacting protein wit h the ability to modulate survival of cancer cells. (PubMed id 21203533)1 Vento M.T....Iaccarino I. (2010)
|
External Searches for PRAF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRAF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRAF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRAF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PRAF2 gene:
Search GeneIP for patents involving PRAF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRAF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | PRAF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAF2 |
|  |  |  | | | | ThermoFisher Antibodies for PRAF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAF2 |
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