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PRAC2 Gene(Protein Coding)

Prostate Cancer Susceptibility Candidate 2

GCID:
GC17P048720
GIFtS:
22
Genes Participants
UDN Logo

Aliases for PRAC2 Gene

Aliases for PRAC2 Gene

  • Prostate Cancer Susceptibility Candidate 2 2 3 5
  • Prostate, Rectum And Colon Expressed Gene Protein 2 3 4
  • Prostate, Rectum And Colon 2 2 3
  • HOXB Cluster Antisense RNA 5 2 3
  • HOXB13-AS1 3 4
  • NCRNA00253 3 4
  • C17orf93 3 4
  • HOXB-AS5 3 4
  • Prostate, Rectum And Colon Expressed Gene 2 Protein 3
  • HOXB Cluster Antisense RNA 5 (Non-Protein Coding) 2
  • HOXB13 Antisense RNA 1 (Non-Protein Coding) 2
  • Chromosome 17 Open Reading Frame 93 2
  • Small Nuclear Protein PRAC2 3
  • Non-Protein Coding RNA 253 2
  • Putative Protein PRCA2 3
  • Putative Protein PRAC2 3

External Ids for PRAC2 Gene

Previous HGNC Symbols for PRAC2 Gene

  • C17orf93
  • NCRNA00253
  • HOXB13-AS1
  • HOXB-AS5

Previous GeneCards Identifiers for PRAC2 Gene

  • GC17U900086
  • GC17P044155
  • GC17P046806
  • GC17P048725

Summaries for PRAC2 Gene

Entrez Gene Summary for PRAC2 Gene

  • This gene is highly expressed in prostate, rectum, colon, and testis. This gene may produce a non-coding RNA or may encode a short protein that might localize to the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for PRAC2 Gene

PRAC2 (Prostate Cancer Susceptibility Candidate 2) is a Protein Coding gene.

Additional gene information for PRAC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAC2 Gene

Genomics for PRAC2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PRAC2 Gene

Promoters and enhancers for PRAC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I048725 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 550.8 +3.0 3025 0.6 SUZ12 CTBP2 FOXP2 ZBTB33 ELF1 ZSCAN29 EZH2 ENSG00000277542 ENSG00000273750 MIR3185 PRAC1 PRAC2
GH17I048722 Promoter/Enhancer 0.9 EPDnew dbSUPER 550.8 +1.7 1728 0.1 SUZ12 EZH2 ENSG00000277542 ENSG00000273750 MIR3185 PRAC1 PRAC2
GH17I048727 Promoter/Enhancer 0.9 EPDnew dbSUPER 550.8 +2.4 2366 0.1 SP1 EZH2 ENSG00000277542 ENSG00000273750 MIR3185 PRAC1 PRAC2
GH17I048719 Enhancer 0.8 ENCODE dbSUPER 550.8 -1.3 -1287 2 HDGF L3MBTL2 SUZ12 FOXM1 POU5F1 CTBP2 ZBTB33 ZFX EZH2 TCF7L2 PRAC2 HOXB13 COX6B1P2
GH17I048994 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.7 +278.6 278639 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 IGF2BP1 ENSG00000250838 ENSG00000262837 UBE2Z FAM117A FLJ45513 ENSG00000238804 PRAC1 PRAC2 HOXB13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRAC2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRAC2 Gene

Genomic Locations for PRAC2 Gene
chr17:48,720,809-48,724,758
(GRCh38/hg38)
Size:
3,950 bases
Orientation:
Plus strand
chr17:46,800,530-46,802,819
(GRCh37/hg19)

Genomic View for PRAC2 Gene

Genes around PRAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAC2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRAC2 Gene

Proteins for PRAC2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PRAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    D3DTV9-PRAC2_HUMAN
    Recommended name:
    Putative protein PRAC2
    Protein Accession:
    D3DTV9

    Protein attributes for PRAC2 Gene

    Size:
    90 amino acids
    Molecular mass:
    10428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAC2 Gene

Post-translational modifications for PRAC2 Gene

No Post-translational modifications

Other Protein References for PRAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAC2 Gene

Domains & Families for PRAC2 Gene

Gene Families for PRAC2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PRAC2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRAC2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PRAC2 Gene

Function for PRAC2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for PRAC2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAC2 Gene

Localization for PRAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAC2 Gene

Nucleus.

Gene Ontology (GO) - Cellular Components for PRAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRAC2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PRAC2 Gene

Pathways & Interactions for PRAC2 Gene

SuperPathways for PRAC2 Gene

PathCards logo More details on SuperPathways for PRAC2
No Data Available

Interacting Proteins for PRAC2 Gene

Gene Ontology (GO) - Biological Process for PRAC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRAC2 Gene

Drugs & Compounds for PRAC2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for PRAC2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PRAC2 Gene

(5) REFSEQ mRNAs :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PRAC2 Gene

No ASD Table

Relevant External Links for PRAC2 Gene

GeneLoc Exon Structure for
PRAC2
ECgene alternative splicing isoforms for
PRAC2

Expression for PRAC2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRAC2 Gene

mRNA expression in normal human tissues for PRAC2 Gene
mRNA expression by GTEx for PRAC2 Gene

mRNA differential expression in normal tissues according to GTEx for PRAC2 Gene

This gene is overexpressed in Prostate (x18.9), Bladder (x7.9), Vagina (x6.2), and Colon - Transverse (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of PRAC2 Gene:

PRAC2

mRNA Expression by UniProt/SwissProt for PRAC2 Gene:

D3DTV9-PRAC2_HUMAN
Tissue specificity: Highly expressed in prostate and testis. Also detected in placenta, muscle, colon, peripheral blood leukocytes and skin.
genes like me logo Genes that share expression patterns with PRAC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAC2 Gene

Orthologs for PRAC2 Gene

Evolution for PRAC2 Gene

ENSEMBL:
Gene Tree for PRAC2 (if available)
TreeFam:
Gene Tree for PRAC2 (if available)

No data available for Orthologs for PRAC2 Gene

Paralogs for PRAC2 Gene

Pseudogenes.org Pseudogenes for PRAC2 Gene

genes like me logo Genes that share paralogs with PRAC2: view

No data available for Paralogs for PRAC2 Gene

Variants for PRAC2 Gene

Sequence variations from dbSNP and Humsavar for PRAC2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000231825 -- 48,724,469(+) T/C coding_sequence_variant, missense_variant
rs1000662927 -- 48,720,065(+) G/T upstream_transcript_variant
rs1000832817 -- 48,724,735(+) G/C 3_prime_UTR_variant
rs1000965281 -- 48,720,261(+) G/A upstream_transcript_variant
rs1002156604 -- 48,721,412(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRAC2 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850

Additional Variant Information for PRAC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRAC2 Gene

Disorders for PRAC2 Gene

Additional Disease Information for PRAC2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAC2 Gene

Publications for PRAC2 Gene

  1. PRAC2: a new gene expressed in human prostate and prostate cancer. (PMID: 12746837) Olsson P … Pastan I (The Prostate 2003) 2 3 4 58
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  3. Inflammation-associated DNA methylation patterns in epithelium of ulcerative colitis. (PMID: 28557546) Barnicle A … Egan LJ (Epigenetics 2017) 3

Products for PRAC2 Gene

Sources for PRAC2 Gene

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