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Aliases for PRAC1 Gene

Aliases for PRAC1 Gene

  • PRAC1 Small Nuclear Protein 2 3 5
  • Prostate Cancer Susceptibility Candidate Protein 1 3 4
  • Prostate, Rectum And Colon Expressed Gene Protein 3 4
  • Prostate Cancer Susceptibility Candidate 1 2 3
  • C17orf92 3 4
  • PRAC 3 4
  • Prostate Cancer Susceptibility Candidate 2
  • Chromosome 17 Open Reading Frame 92 2
  • Small Nuclear Protein PRAC1 3
  • Prostate, Rectum And Colon 2
  • Small Nuclear Protein PRAC 3

External Ids for PRAC1 Gene

Previous HGNC Symbols for PRAC1 Gene

  • C17orf92
  • PRAC

Previous GeneCards Identifiers for PRAC1 Gene

  • GC17M046800

Summaries for PRAC1 Gene

Entrez Gene Summary for PRAC1 Gene

  • This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRAC1 Gene

PRAC1 (PRAC1 Small Nuclear Protein) is a Protein Coding gene. Diseases associated with PRAC1 include Prostate Cancer Susceptibility and Autosomal Dominant Microcephaly.

Additional gene information for PRAC1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAC1 Gene

Genomics for PRAC1 Gene

Regulatory Elements for PRAC1 Gene

Enhancers for PRAC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H049020 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -299.5 -299473 3.6 ARID4B ZSCAN9 RFX5 EGR1 SCRT2 RCOR1 ZNF362 HMG20B CEBPB NFYC SNF8 PRAC1 RNU1-42P ENSG00000230532 ENSG00000238804 PRAC2 HOXB-AS4 HOXB9 IGF2BP1 ENSG00000255851
GH17H048994 1.6 Ensembl ENCODE dbSUPER 10.7 -276.9 -276926 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ENSG00000262837 UBE2Z FAM117A ENSG00000238804 SUMO2P17 KAT7 PRAC1 PRAC2 HOXB13 CALCOCO2
GH17H048623 1.6 FANTOM5 ENCODE dbSUPER 9.6 +95.9 95872 6.4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF766 CBX5 SP3 REST ZNF592 ENSG00000264701 ENSG00000230532 SUMO2P17 SP2 CDK5RAP3 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811
GH17H049011 1.5 Ensembl ENCODE dbSUPER 10.1 -292.0 -291982 5.9 FOXA2 ZFP64 SIN3A FEZF1 ZBTB7B ETS1 GLIS2 FOS SP3 SP5 ENSG00000238804 PRAC1 PRAC2 HOXB-AS4 HOXB9 IGF2BP1 ATP5G1 UBE2Z SNF8 ENSG00000255851
GH17H048869 1.3 Ensembl ENCODE 10.7 -149.2 -149184 5.1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SP5 MXD4 ATP5G1 TTLL6 CALCOCO2 UBE2Z ENSG00000230532 HOXB13 PRAC1 PRAC2 SUMO2P17 LOC105371811
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRAC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRAC1 Gene

Genomic Locations for PRAC1 Gene
chr17:48,721,719-48,722,522
(GRCh38/hg38)
Size:
804 bases
Orientation:
Minus strand
chr17:46,799,081-46,799,884
(GRCh37/hg19)

Genomic View for PRAC1 Gene

Genes around PRAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAC1 Gene

Proteins for PRAC1 Gene

  • Protein details for PRAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KF2-PRAC1_HUMAN
    Recommended name:
    Small nuclear protein PRAC1
    Protein Accession:
    Q96KF2

    Protein attributes for PRAC1 Gene

    Size:
    57 amino acids
    Molecular mass:
    5959 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAC1 Gene

Post-translational modifications for PRAC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAC1 Gene

Domains & Families for PRAC1 Gene

Gene Families for PRAC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRAC1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRAC1: view

No data available for UniProtKB/Swiss-Prot for PRAC1 Gene

Function for PRAC1 Gene

Phenotypes From GWAS Catalog for PRAC1 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAC1 Gene

Localization for PRAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAC1 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for PRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRAC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRAC1 Gene

Pathways & Interactions for PRAC1 Gene

SuperPathways for PRAC1 Gene

No Data Available

Interacting Proteins for PRAC1 Gene

Gene Ontology (GO) - Biological Process for PRAC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRAC1 Gene

Drugs & Compounds for PRAC1 Gene

No Compound Related Data Available

Transcripts for PRAC1 Gene

mRNA/cDNA for PRAC1 Gene

(1) REFSEQ mRNAs :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAC1 Gene

No ASD Table

Relevant External Links for PRAC1 Gene

GeneLoc Exon Structure for
PRAC1
ECgene alternative splicing isoforms for
PRAC1

Expression for PRAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRAC1 Gene

mRNA differential expression in normal tissues according to GTEx for PRAC1 Gene

This gene is overexpressed in Prostate (x23.1), Colon - Transverse (x15.8), and Bladder (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of PRAC1 Gene:

PRAC1

mRNA Expression by UniProt/SwissProt for PRAC1 Gene:

Q96KF2-PRAC1_HUMAN
Tissue specificity: Highly expressed in prostate, rectum, and distal colon, and weakly expressed in bladder. Expressed in prostate cancer cell lines.

Evidence on tissue expression from TISSUES for PRAC1 Gene

  • Intestine(2.3)
genes like me logo Genes that share expression patterns with PRAC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAC1 Gene

Orthologs for PRAC1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRAC 33
  • 98.83 (n)
PRAC1 34
  • 98 (a)
OneToOne
Species where no ortholog for PRAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAC1 Gene

ENSEMBL:
Gene Tree for PRAC1 (if available)
TreeFam:
Gene Tree for PRAC1 (if available)

Paralogs for PRAC1 Gene

No data available for Paralogs for PRAC1 Gene

Variants for PRAC1 Gene

Sequence variations from dbSNP and Humsavar for PRAC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000231825 -- 48,724,469(+) CTTCT(C/T)CCATT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1002156604 -- 48,721,412(+) CCTCC(A/G)CCTCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002619350 -- 48,724,025(+) AGTAT(A/T)TGTGT intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1003273521 -- 48,724,421(+) CAGAA(A/G)GCGGA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1005278892 -- 48,723,783(+) TCTAC(A/C/G)CATTG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRAC1 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850

Variation tolerance for PRAC1 Gene

Gene Damage Index Score: 0.95; 19.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAC1 Gene

Disorders for PRAC1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRAC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
autosomal dominant microcephaly
  • microcephaly autosomal dominant
prostate cancer
  • prostate cancer, hereditary, 5
johanson-blizzard syndrome
  • jbs
- elite association - COSMIC cancer census association via MalaCards
Search PRAC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRAC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAC1
genes like me logo Genes that share disorders with PRAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAC1 Gene

Publications for PRAC1 Gene

  1. PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon. (PMID: 11340635) Liu XF … Pastan I (The Prostate 2001) 2 3 4 60
  2. Clinical Implications and Prognostic Values of Prostate Cancer Susceptibility Candidate Methylation in Primary Nonmuscle Invasive Bladder Cancer. (PMID: 26074659) Kim YW … Kim YJ (Disease markers 2015) 3 60
  3. Aberrant expression of the PRAC gene in prostate cancer. (PMID: 24100630) Lenka G … Pang ST (International journal of oncology 2013) 3 60
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for PRAC1 Gene

Sources for PRAC1 Gene

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