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Aliases for PQLC2L Gene

Aliases for PQLC2L Gene

  • PQ Loop Repeat Containing 2 Like 2 3 5
  • PQ-Loop Repeat-Containing Protein 2-Like 3 4
  • C3orf55 3 4
  • Putative Uncharacterized Protein PQLC2L 3
  • Chromosome 3 Open Reading Frame 55 2

External Ids for PQLC2L Gene

Previous HGNC Symbols for PQLC2L Gene

  • C3orf55

Summaries for PQLC2L Gene

GeneCards Summary for PQLC2L Gene

PQLC2L (PQ Loop Repeat Containing 2 Like) is a Protein Coding gene. An important paralog of this gene is PQLC2.

Additional gene information for PQLC2L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PQLC2L Gene

Genomics for PQLC2L Gene

Regulatory Elements for PQLC2L Gene

Enhancers for PQLC2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H157530 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.8 -11.0 -10966 4 ARNT NFRKB RAD21 ZNF766 ZNF143 FOS ZNF654 ZNF280D ZBTB11 CEBPB VEPH1 PQLC2L PTX3
GH03H157526 1.1 Ensembl ENCODE dbSUPER 6.5 -15.1 -15143 2 TAL1 ZSCAN4 USF2 ZBTB40 NCOR1 FOXJ2 FOXP2 MAFK VEPH1 PQLC2L PTX3
GH03H157606 0.6 ENCODE 10.9 +63.5 63511 0 ELF3 CTCF ETV1 ELF1 RAD21 FOSL1 KLF16 ZNF143 SMC3 MIXL1 PQLC2L GC03M157580 GC03P157696
GH03H157066 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.2 -476.1 -476135 1 CTCF L3MBTL2 TAL1 NR2F1 CHD1 GATA3 HNF4A FOS RUNX3 MAFK TIPARP-AS1 TIPARP LINC00886 PQLC2L PTX3 LINC02029 RN7SKP177
GH03H157542 0.4 ENCODE 14.5 +0.1 105 1 CTCF POLR2A VEPH1 PQLC2L GC03M157580
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PQLC2L on UCSC Golden Path with GeneCards custom track

Promoters for PQLC2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160955 54 1001 CTCF POLR2A

Genomic Location for PQLC2L Gene

Chromosome:
3
Start:
157,543,246 bp from pter
End:
157,677,750 bp from pter
Size:
134,505 bases
Orientation:
Plus strand

Genomic View for PQLC2L Gene

Genes around PQLC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PQLC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PQLC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PQLC2L Gene

Proteins for PQLC2L Gene

  • Protein details for PQLC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A4F0-CC055_HUMAN
    Recommended name:
    Putative uncharacterized protein PQLC2L
    Protein Accession:
    A1A4F0
    Secondary Accessions:
    • C9JP04
    • C9JXB5
    • Q8N6Q6

    Protein attributes for PQLC2L Gene

    Size:
    135 amino acids
    Molecular mass:
    15626 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29129.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for PQLC2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PQLC2L Gene

Post-translational modifications for PQLC2L Gene

No Post-translational modifications

No data available for DME Specific Peptides for PQLC2L Gene

Domains & Families for PQLC2L Gene

Gene Families for PQLC2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PQLC2L Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PQLC2L: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PQLC2L Gene

Function for PQLC2L Gene

Phenotypes From GWAS Catalog for PQLC2L Gene

Phenotypes for PQLC2L Gene

genes like me logo Genes that share phenotypes with PQLC2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PQLC2L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PQLC2L Gene

Localization for PQLC2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PQLC2L gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PQLC2L Gene

Pathways & Interactions for PQLC2L Gene

SuperPathways for PQLC2L Gene

No Data Available

Interacting Proteins for PQLC2L Gene

Gene Ontology (GO) - Biological Process for PQLC2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PQLC2L Gene

Drugs & Compounds for PQLC2L Gene

No Compound Related Data Available

Transcripts for PQLC2L Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PQLC2L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PQLC2L Gene

No ASD Table

Relevant External Links for PQLC2L Gene

GeneLoc Exon Structure for
PQLC2L
ECgene alternative splicing isoforms for
PQLC2L

Expression for PQLC2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PQLC2L Gene

Protein differential expression in normal tissues from HIPED for PQLC2L Gene

This gene is overexpressed in Spinal cord (29.3), Prostate (21.8), and Gallbladder (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PQLC2L Gene



NURSA nuclear receptor signaling pathways regulating expression of PQLC2L Gene:

PQLC2L
genes like me logo Genes that share expression patterns with PQLC2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PQLC2L Gene

Orthologs for PQLC2L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PQLC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3orf55 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf55 34
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3orf55 34
  • 7 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
OneToMany
-- 34
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea laat-1 34
  • 10 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 9 (a)
ManyToMany
RTC2 34
  • 9 (a)
ManyToMany
-- 34
  • 8 (a)
ManyToMany
Species where no ortholog for PQLC2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PQLC2L Gene

ENSEMBL:
Gene Tree for PQLC2L (if available)
TreeFam:
Gene Tree for PQLC2L (if available)

Paralogs for PQLC2L Gene

Paralogs for PQLC2L Gene

genes like me logo Genes that share paralogs with PQLC2L: view

Variants for PQLC2L Gene

Sequence variations from dbSNP and Humsavar for PQLC2L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000000012 -- 157,590,243(+) CCACC(A/G)TTTGA intron-variant
rs1000002378 -- 157,549,771(+) CTAGT(A/T)CTAAT intron-variant
rs1000012389 -- 157,569,083(+) TAGGA(A/T)CAACT intron-variant
rs1000049105 -- 157,562,194(+) GTTAG(A/G)TGCAT intron-variant
rs1000095155 -- 157,601,537(+) TAAAA(C/T)GAAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PQLC2L Gene

Variant ID Type Subtype PubMed ID
esv2726098 CNV deletion 23290073
nsv4081 CNV deletion 18451855
nsv829767 CNV loss 17160897

Variation tolerance for PQLC2L Gene

Gene Damage Index Score: 0.69; 14.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PQLC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PQLC2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PQLC2L Gene

Disorders for PQLC2L Gene

Relevant External Links for PQLC2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PQLC2L

No disorders were found for PQLC2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PQLC2L Gene

Publications for PQLC2L Gene

  1. Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking. (PMID: 22363504) Saudek V (PloS one 2012) 2 3 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3 60

Products for PQLC2L Gene

Sources for PQLC2L Gene

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