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Aliases for PQLC2L Gene

Aliases for PQLC2L Gene

  • PQ Loop Repeat Containing 2 Like 2 3 5
  • PQ-Loop Repeat-Containing Protein 2-Like 3 4
  • C3orf55 3 4
  • Putative Uncharacterized Protein PQLC2L 3
  • Chromosome 3 Open Reading Frame 55 2

External Ids for PQLC2L Gene

Previous HGNC Symbols for PQLC2L Gene

  • C3orf55

Summaries for PQLC2L Gene

GeneCards Summary for PQLC2L Gene

PQLC2L (PQ Loop Repeat Containing 2 Like) is a Protein Coding gene. An important paralog of this gene is PQLC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PQLC2L Gene

Genomics for PQLC2L Gene

Regulatory Elements for PQLC2L Gene

Enhancers for PQLC2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F157530 1.1 FANTOM5 Ensembl ENCODE 14.8 -11.0 -11023 4.4 RAD21 ZNF121 ZNF366 FOS ZNF362 ZNF654 ZNF280D ZBTB11 ZEB2 REST VEPH1 PQLC2L PTX3
GH03F157542 0.2 ENCODE 14.5 +0.1 105 1.2 CTCF POLR2A RAD21 VEPH1 PQLC2L GC03M157580
GH03F157502 0.2 ENCODE 11.1 -39.4 -39387 1.8 ZNF316 GATA3 JUND PKNOX1 PBX2 CEBPA CUX1 VEPH1 PQLC2L PTX3
GH03F157606 0.8 Ensembl ENCODE 10.8 +63.4 63421 0.6 ZNF263 ELF3 CTCF ETV1 ZBTB7A RAD21 JUND KLF16 GABPB1 ZNF143 PQLC2L GC03M157580 GC03P157696
GH03F157526 0.2 ENCODE 6.5 -15.1 -15143 2.4 TAL1 ZBTB40 ARID1B NCOR1 ATF3 PBX2 FOXP2 FOXJ2 MAFK VEPH1 PQLC2L PTX3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PQLC2L on UCSC Golden Path with GeneCards custom track

Promoters for PQLC2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001377817 54 1400 CTCF POLR2A RAD21

Genomic Location for PQLC2L Gene

Chromosome:
3
Start:
157,543,246 bp from pter
End:
157,677,750 bp from pter
Size:
134,505 bases
Orientation:
Plus strand

Genomic View for PQLC2L Gene

Genes around PQLC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PQLC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PQLC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PQLC2L Gene

Proteins for PQLC2L Gene

  • Protein details for PQLC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A4F0-CC055_HUMAN
    Recommended name:
    Putative uncharacterized protein PQLC2L
    Protein Accession:
    A1A4F0
    Secondary Accessions:
    • C9JP04
    • C9JXB5
    • Q8N6Q6

    Protein attributes for PQLC2L Gene

    Size:
    135 amino acids
    Molecular mass:
    15626 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29129.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for PQLC2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PQLC2L Gene

Post-translational modifications for PQLC2L Gene

No Post-translational modifications

No data available for DME Specific Peptides for PQLC2L Gene

Domains & Families for PQLC2L Gene

Protein Domains for PQLC2L Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PQLC2L: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PQLC2L Gene

Function for PQLC2L Gene

Gene Ontology (GO) - Molecular Function for PQLC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015181 arginine transmembrane transporter activity IBA --
GO:0015189 L-lysine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with PQLC2L: view

Phenotypes for PQLC2L Gene

genes like me logo Genes that share phenotypes with PQLC2L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PQLC2L Gene

Localization for PQLC2L Gene

Gene Ontology (GO) - Cellular Components for PQLC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with PQLC2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for PQLC2L Gene

Pathways & Interactions for PQLC2L Gene

SuperPathways for PQLC2L Gene

No Data Available

Interacting Proteins for PQLC2L Gene

Gene Ontology (GO) - Biological Process for PQLC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903401 L-lysine transmembrane transport IEA --
GO:1903826 arginine transmembrane transport IEA --
genes like me logo Genes that share ontologies with PQLC2L: view

No data available for Pathways by source and SIGNOR curated interactions for PQLC2L Gene

Transcripts for PQLC2L Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PQLC2L Gene

No ASD Table

Relevant External Links for PQLC2L Gene

GeneLoc Exon Structure for
PQLC2L
ECgene alternative splicing isoforms for
PQLC2L

Expression for PQLC2L Gene

mRNA expression in normal human tissues for PQLC2L Gene

Protein differential expression in normal tissues from HIPED for PQLC2L Gene

This gene is overexpressed in Spinal cord (29.3), Prostate (21.8), and Gallbladder (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PQLC2L Gene



NURSA nuclear receptor signaling pathways regulating expression of PQLC2L Gene:

PQLC2L
genes like me logo Genes that share expression patterns with PQLC2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PQLC2L Gene

Orthologs for PQLC2L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PQLC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3orf55 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf55 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3orf55 35
  • 7 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
OneToMany
-- 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea laat-1 35
  • 10 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 9 (a)
ManyToMany
RTC2 35
  • 9 (a)
ManyToMany
-- 35
  • 8 (a)
ManyToMany
Species where no ortholog for PQLC2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PQLC2L Gene

ENSEMBL:
Gene Tree for PQLC2L (if available)
TreeFam:
Gene Tree for PQLC2L (if available)

Paralogs for PQLC2L Gene

Paralogs for PQLC2L Gene

genes like me logo Genes that share paralogs with PQLC2L: view

Variants for PQLC2L Gene

Sequence variations from dbSNP and Humsavar for PQLC2L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10222436 -- 157,581,938(+) acagc(C/T)gtggg intron-variant
rs10554207 -- 157,591,175(+) TTCCT(-/TTCC)TTCCT intron-variant
rs10574904 -- 157,545,016(+) TATGA(-/T)TTTTT intron-variant
rs10656756 -- 157,599,630(+) GGCCT(-/CTCT)AAGTG intron-variant
rs10662380 -- 157,544,038(+) GCTAT(-/TTA/TTATTA/TTATTATTATTA/TTATTATTATTATTA)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PQLC2L Gene

Variant ID Type Subtype PubMed ID
esv2726098 CNV deletion 23290073
nsv4081 CNV deletion 18451855
nsv829767 CNV loss 17160897

Variation tolerance for PQLC2L Gene

Gene Damage Index Score: 0.69; 14.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PQLC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PQLC2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PQLC2L Gene

Disorders for PQLC2L Gene

Relevant External Links for PQLC2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PQLC2L

No disorders were found for PQLC2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PQLC2L Gene

Publications for PQLC2L Gene

  1. Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking. (PMID: 22363504) Saudek V. (PLoS ONE 2012) 2 3 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3 64

Products for PQLC2L Gene

Sources for PQLC2L Gene

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