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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPYR1 Gene

protein-coding GIFtS: 62
GCID: GC10P047083

pancreatic polypeptide receptor 1

Explore 17 diseases affiliated with
PPYR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Pancreatic Polypeptide Receptor 1¹ ² ³
NPY4R¹ ² ³ ⁵
PP1¹ ² ³ ⁵
Y4¹ ²
NPY4-R² ³
Neuropeptide Y Receptor Type 4²

External Ids:	HGNC: 9329¹	Entrez Gene: 5540²	Ensembl: ENSG00000204174⁷	OMIM: 601790⁵	UniProtKB: P50391³

Export aliases for PPYR1 gene to outside databases

Previous GC identifers: GC10P046384 GC10P047204 GC10P046952 GC10P046462 GC10P9E0182 GC10P046505

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391

Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic

polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36)

and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

summary for PPYR1:

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided

into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including

stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of

pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and

colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding

Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on

chromosome 10q11.2.

Gene Wiki entry for PPYR1 (Pancreatic polypeptide receptor 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_031847.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPYR1 gene promoter:
C/EBPbeta Brachyury MIF-1 CUTL1 HNF-4alpha2 HNF-4alpha1 PPAR-gamma1 FOXO4 ARP-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPYR1 promoter sequence

Search SABiosciences Chromatin IP Primers for PPYR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPYR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.2

PPYR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPYR1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P047083: view genomic region (about GC identifiers)

Start:	47,083,534 bp from pter	End:	47,088,320 bp from pter
Size:	4,787 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391 (See protein sequence)

Recommended Name: Neuropeptide Y receptor type 4

Size: 375 amino acids; 42195 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

1 PDB 3D structure from and Proteopedia for PPYR1:

2IK5 (3D)

Secondary accessions: Q13456 Q5ISU3 Q5T2X9 Q6FH06

Explore the universe of human proteins at neXtProt for PPYR1: NX_P50391

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P50391

PPYR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005963.3

ENSEMBL proteins:

ENSP00000379066 ENSP00000363431

Reactome Protein details: P50391
Human Recombinant Protein Products for PPYR1:

	EMD Millipore Purified and/or Recombinant PPYR1 Protein
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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for PPYR1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8643460

PPYR1 for ontologies About GeneDecksing

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Assay Products for PPYR1:

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	GenScript PPYR1-overexpressing Cell Line for Assay
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	Uscn ELISAs and CLIAs for PPYR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPYR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR001933 NPY4_rcpt

IPR000276 GPCR_Rhodpsn

IPR000611 NPY_rcpt

Graphical View of Domain Structure for InterPro Entry P50391

ProtoNet protein and cluster: P50391

2 Blocks protein families:

IPB000611 Neuropeptide Y receptor signature

IPB001933 Neuropeptide Y4 receptor signature

UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NPY4R_HUMAN, P50391

Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic

polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36)

and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

Genatlas biochemistry entry for PPYR1:

pancreatic peptide receptor 1,G protein coupled receptor family,Y receptor subfamily,expressed in colon,pancreas

intestinal,heart,testis,skeletal muscle,but also in hypothalamus,amygdale,thalamus,stimulated by NPY,PYY,PPY,with the

highest affinity for PPY

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001601	peptide YY receptor activity	IEA	--
GO:0001602	pancreatic polypeptide receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	8643460
GO:0042277	peptide binding	IEA	--

PPYR1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PPYR1:

Decreased Salmonella enterica

Decreased number of cells in m

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ppyr1):

adipose tissue	behavior/neurological	endocrine/exocrine gland	growth/size	homeostasis/metabolism
integument	normal	reproductive system	skeleton

PPYR1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PPYR1: Ppyr1^tm1.1Hhz Ppyr1^tm1Lex

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PPYR1

miRNA Products:		OriGene 3'-UTR Clone: PPYR1 Browse MicroRNA Expression Plasmids
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		hsa-miR-221* hsa-miR-3194-5p
		SwitchGear 3'UTR luciferase reporter plasmid: PPYR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPYR1 (see all 7) OriGene shRNA RFP: PPYR1 OriGene siRNA: PPYR1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PPYR1

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Clone Products:		EMD Millipore Clones for the Expression of PPYR1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPYR1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PPYR1

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

2 BioSystems Pathways for PPYR1

	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/7 Reactome Pathways for PPYR1 (see all 7)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events

1 Kegg Pathway (Kegg details for PPYR1):

Neuroactive ligand-receptor interaction

PPYR1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PPYR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for PPYR1 (P50391³ ENSP00000363431⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 143)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NPY	P01303³, ENSP00000242152⁴	I2D: score=1 STRING: ENSP00000242152
PPY	P01298³, ENSP00000225992⁴	I2D: score=1 STRING: ENSP00000225992
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
DRD4	ENSP00000176183⁴	STRING: ENSP00000176183
GALR1	ENSP00000299727⁴	STRING: ENSP00000299727

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	TAS	7592911
GO:0007586	digestion	TAS	7592911
GO:0007631	feeding behavior	TAS	7592911
GO:0008015	blood circulation	TAS	7592911

PPYR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPYR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PPYR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
GR 231118	Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors	[158859-98-4]
Sarafotoxin S6c	Selective ETB agonist	[121695-87-2]
[Leu31,Pro34]-Neuropeptide Y (porcine)	NPY Y1 receptor agonist	[125580-28-1]
Neuropeptide Y (porcine)	Influences feeding and sexual behavior	--
Pancreatic Polypeptide (human)	NPY Y4 agonist; involved in gastrointestinal tract function	[59763-91-6]

10/25 Novoseek chemical compound relationships for PPYR1 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibo3304	81.5	2	16807358 (1), 15947033 (1)
calyculin a	76.8	15	8415615 (2), 8567754 (2), 8750856 (2), 11160648 (2) (see all 7)
okadaic acid	75	34	10462539 (2), 10504605 (2), 9599018 (2), 8750856 (2) (see all 19)
tautomycin	69.5	4	7864167 (1), 10485875 (1), 15772123 (1)
threonine	65.6	21	1668387 (1), 15464122 (1), 10462539 (1), 11062237 (1) (see all 20)
serine	56.9	21	1668387 (1), 15464122 (1), 17123353 (1), 10462539 (1) (see all 21)
microcystin-lr	51.9	3	11160648 (1), 18282792 (1)
tyrosine	40.5	14	10764762 (1), 11062237 (1), 17210286 (1), 10764819 (1) (see all 12)
phosphatidylinositol	37.4	3	14741844 (1), 16530387 (1), 11739176 (1)
gf 109203x	28.1	2	11853873 (1), 15750341 (1)

Search CenterWatch for drugs/clinical trials and news about PPYR1 / NPY4R

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPYR1 gene:

NM_005972.4

Unigene Cluster for PPYR1:

Pancreatic polypeptide receptor 1

Hs.524719 [show with all ESTs]

Unigene Representative Sequence: NM_005972

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395716 ENST00000374312(uc001jee.3 uc009xna.3)

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		hsa-miR-221* hsa-miR-3194-5p
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PPYR1

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Additional cDNA sequence:

AY649985.1 AY649986.1 BC096237.1 BC096238.3 BC099637.3 CR541950.1 U42387.1

1 DOTS entry:

DT.406393

3 AceView cDNA sequences:

CR541950 U42387 NM_005972

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPYR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCCACCT

About this image

PPYR1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PPYR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPYR1

SOURCE GeneReport for Unigene cluster: Hs.524719

UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391

Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney.

Detected in colon and small intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including PPYR1:

G Protein Coupled Receptors 384HT in human mouse rat

Neurotrophins & Receptors in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPYR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPYR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PPYR1 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PPYR1¹	pancreatic polypeptide receptor 1	64.71(n) 60.89(a)		428955 NM_001031555.1 NP_001026726.1
lizard (Anolis carolinensis)	Reptilia	-- PPYR1⁶ (see all 3)	--	53(a) 50(a) (see all 3)	possible ortholog 1 ↔ 1 (see all 3)	GL343484.1(92462-93547) GL343297.1(436691-437818)
zebrafish (Danio rerio)	Actinopterygii	npyryc²	neuropeptide Y/peptide YY receptor YC	74.57(n)		30714 NM_131437.1
fruit fly (Drosophila melanogaster)	Insecta	NPFR1³	G-protein coupled receptor protein signaling pathway more	31(a)		--
worm (Caenorhabditis elegans)	Secernentea	npr-12⁶ npr-11⁶ (see all 3)	Putative neuropeptide Y receptor 11 (see all 3)	19(a) 19(a) (see all 3)	many ↔ many many ↔ many (see all 3)	IV(6929077-6931107) X(1251020-1256002)

ENSEMBL Gene Tree for PPYR1 (if available)
TreeFam Gene Tree for PPYR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPYR1 gene

GPR83² HCRTR2² PRLHR² NPFFR2² NPY5R² TACR1² TACR3² NPY1R²

QRFPR² NPFFR1² NPY2R² HCRTR1² TACR2²

11 SIMAP similar genes for PPYR1 using alignment to 2 protein entries: NPY4R_HUMAN (see all proteins):

NPY1R NPY6R CMKLR1 GIR PRLHR GPR83

NPFFR1 NPFFR2 QRFPR NPY2R TACR1

PPYR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201274411^1,2		--	47081555(+)	`TTCTC-/AAATGT`	1	--	us2k¹		0	--	--	--	--
rs6599574^1,2	C,F,A	--	47081751(+)	`CTACCG/ATTACA`	1	--	us2k¹		11		NA WA CSA	137
rs1981310^1,2	C,F,A	--	47081756(+)	`ATTACA/CATCAG`	1	--	us2k¹		8		NA WA CSA	20
rs3916231^1,2	C,F,A	--	47081860(+)	`GGAGAC/AAAGAG`	1	--	us2k¹		4		NA WA	8
rs5784729^1,2	C	--	47081889(+)	`GGGGAG/-ACAAA`	1	--	us2k¹		3		NA CSA	6
rs1573213^1,2	C,F,A	--	47081900(+)	`CAAAGG/CTGCTC`	1	--	us2k¹		9		NA WA CSA	20
rs3929938^1,2	C,F,A	--	47081938(+)	`TCTGCT/CTCTGC`	1	--	us2k¹		11		NA WA CSA	22
rs3929939^1,2	C,F	--	47082009(+)	`GCAACG/AGAGGA`	1	--	us2k¹		14		NA WA CSA	163
rs7904975^1,2	C,F,H	--	47082047(+)	`GGAAGG/CAGCAT`	1	--	us2k¹ tfbs³		13		EA NS NA WA CSA	316
rs7922433^1,2	C,F,A	--	47082282(+)	`AGTCTC/ATGCAC`	1	--	us2k¹		9		NA WA CSA	17

HapMap Linkage Disequilibrium report for PPYR1 (47083534 - 47088320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 34 variations for PPYR1
15/33 CNVs (see all 33): 9150 3798 8647 8646 34572 0136 48545 0307 8651 31728 9640 34554 48541 48535 48542
1 Indel: 61016

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPYR1 for disorders           About GeneDecksing

OMIM gene information: 601790    OMIM disorders: --

17 diseases for PPYR1:    About MalaCards

pancreatitis drug dependence neuroepithelioma cystic fibrosis

alzheimer's disease fibrosis pertussis peritonitis

lung cancer breast cancer ischemia glioblastoma

obesity cerebritis neuroblastoma neuronitis

alcoholism

1 Novoseek disease relationship for PPYR1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	32.1	2	7812792 (1), 15895832 (1)

Human Genome Epidemiology (HuGE) Navigator: PPYR1 (2 documents)

Export disorders for PPYR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPYR1 gene, integrated from 9 sources (see all 169):
(articles sorted by number of sources associating them with PPYR1)

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world of online information

Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PubMed id 7592911)^{1, 2, 9} Bard J.A.... Weinshank R.L. (1995)
Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PubMed id 9417917)^{1, 3, 9} Lutz C.M....Thompson D.A. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PubMed id 8643460)^{1, 2} Yan H....Karbon W. (1996)
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. (PubMed id 7493937)^{1, 2} Lundell I.... Larhammar D. (1995)
Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PubMed id 19481128)^{1, 9} Umeda T....Iwaasa H. (2009)
Clinical potentials of neuropeptide Y family of hormones. (PubMed id 11975932)^{1, 9} Balasubramaniam A. (2002)
Structure and receptor binding of PYY analogs. (PubMed id 11825645)^{1, 9} Keire D.A....Reeve J.R. (2002)
Comparison of fragments comprising the first two helic es of the human Y4 and the yeast Ste2p G-protein-coupled receptors. (PubMed id 22947943)¹ Shao X....Zerbe O. (2012)
Functional reconstitution of human neuropeptide Y (NP Y) Y(2) and Y(4) receptors in Sf9 insect cells. (PubMed id 21745157)¹ Pop N....Buschauer A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5540	HGNC: 9329	AceView: PPYR1	Ensembl:ENSG00000204174	euGenes: HUgn5540
ECgene: PPYR1	Kegg: 5540	H-InvDB: PPYR1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPYR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PPYR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PPYR1 gene:
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pancreatic polypeptide receptor 1

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pancreatic polypeptide receptor 1

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