Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPY Gene

Aliases for PPY Gene

  • Pancreatic Polypeptide 2 3 4
  • Prepro-PP (Prepropancreatic Polypeptide) 2 3
  • Pancreatic Polypeptide Y 2 3
  • PNP 3 4
  • PP 3 4
  • Pancreatic Prohormone 3
  • Obinepitide 4

External Ids for PPY Gene

Previous GeneCards Identifiers for PPY Gene

  • GC17M041760
  • GC17M044195
  • GC17M042028
  • GC17M042493
  • GC17M039373
  • GC17M037782

Summaries for PPY Gene

Entrez Gene Summary for PPY Gene

  • This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPY Gene

PPY (Pancreatic Polypeptide) is a Protein Coding gene. Diseases associated with PPY include pancreatic cholera and cholera. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for PPY Gene

  • Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions

  • The physiological role for the icosapeptide has not yet been elucidated

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPY Gene

Genomics for PPY Gene

Regulatory Elements for PPY Gene

Genomic Location for PPY Gene

Start:
43,940,804 bp from pter
End:
43,942,468 bp from pter
Size:
1,665 bases
Orientation:
Minus strand

Genomic View for PPY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPY Gene

Proteins for PPY Gene

  • Protein details for PPY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01298-PAHO_HUMAN
    Recommended name:
    Pancreatic prohormone
    Protein Accession:
    P01298
    Secondary Accessions:

    Protein attributes for PPY Gene

    Size:
    95 amino acids
    Molecular mass:
    10445 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PPY Gene

neXtProt entry for PPY Gene

Proteomics data for PPY Gene at MOPED

Post-translational modifications for PPY Gene

No Post-translational modifications

Other Protein References for PPY Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PPY Gene

Domains for PPY Gene

Gene Families for PPY Gene

HGNC:

Protein Domains for PPY Gene

Suggested Antigen Peptide Sequences for PPY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01298

UniProtKB/Swiss-Prot:

PAHO_HUMAN :
  • P01298
Family:
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PPY: view

Function for PPY Gene

Molecular function for PPY Gene

GENATLAS Biochemistry: pancreatic polypeptide hormone precursor,expressed in the PP cells of the pancreas,regulator of pancreatic and gastrointestinal functions
UniProtKB/Swiss-Prot Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions
UniProtKB/Swiss-Prot Function: The physiological role for the icosapeptide has not yet been elucidated

Gene Ontology (GO) - Molecular Function for PPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005102 receptor binding TAS 6373251
GO:0005179 hormone activity TAS 2997153
GO:0005184 neuropeptide hormone activity IBA --
genes like me logo Genes that share ontologies with PPY: view
genes like me logo Genes that share phenotypes with PPY: view

Animal Models for PPY Gene

MGI Knock Outs for PPY:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPY Gene

Localization for PPY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPY Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPY Gene COMPARTMENTS Subcellular localization image for PPY gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with PPY: view

Pathways for PPY Gene

genes like me logo Genes that share pathways with PPY: view

Gene Ontology (GO) - Biological Process for PPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
GO:0007586 digestion TAS 6373251
GO:0007631 feeding behavior IBA --
genes like me logo Genes that share ontologies with PPY: view

Compounds for PPY Gene

UniProtKB/Swiss-Prot:

P01298-PAHO_HUMAN
Pharmaceutical: Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63
genes like me logo Genes that share compounds with PPY: view

Transcripts for PPY Gene

mRNA/cDNA for PPY Gene

Unigene Clusters for PPY Gene

Pancreatic polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPY Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for PPY Gene

GeneLoc Exon Structure for
PPY
ECgene alternative splicing isoforms for
PPY

Expression for PPY Gene

mRNA expression in normal human tissues for PPY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPY Gene

This gene is overexpressed in Pancreas (52.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPY Gene

SOURCE GeneReport for Unigene cluster for PPY Gene Hs.558368

genes like me logo Genes that share expressions with PPY: view

No data available for mRNA Expression by UniProt/SwissProt for PPY Gene

Orthologs for PPY Gene

This gene was present in the common ancestor of mammals.

Orthologs for PPY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPY 35
  • 98.6 (n)
  • 100 (a)
PPY 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPY 35
  • 86.88 (n)
  • 82.98 (a)
PPY 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPY 35
  • 84.07 (n)
  • 77.78 (a)
PPY 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppy 35
  • 80.56 (n)
  • 75 (a)
Ppy 16
Ppy 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPY 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppy 35
  • 81.48 (n)
  • 77.78 (a)
Species with no ortholog for PPY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPY Gene

ENSEMBL:
Gene Tree for PPY (if available)
TreeFam:
Gene Tree for PPY (if available)

Paralogs for PPY Gene

Selected SIMAP similar genes for PPY Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPY Gene

genes like me logo Genes that share paralogs with PPY: view

No data available for Paralogs for PPY Gene

Variants for PPY Gene

Sequence variations from dbSNP and Humsavar for PPY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs231471 -- 43,942,126(-) GGACA(A/G)TAGCG intron-variant
rs231472 -- 43,942,010(-) ACCCT(C/G)TGGGT intron-variant
rs231473 -- 43,941,103(-) CCTGG(A/G)GCTGA intron-variant
rs1642603 -- 43,944,339(-) GTTTA(C/T)CTCTG upstream-variant-2KB
rs7215698 - 43,941,173(+) CCCAC(C/T)CCGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PPY Gene

Variant ID Type Subtype PubMed ID
esv993450 CNV Deletion 20482838
nsv833454 CNV Loss 17160897

Relevant External Links for PPY Gene

HapMap Linkage Disequilibrium report
PPY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPY Gene

Disorders for PPY Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for PPY Gene including...

Search for PPY Gene in MalaCards »

Relevant External Links for PPY

Genetic Association Database (GAD)
PPY
Human Genome Epidemiology (HuGE) Navigator
PPY
genes like me logo Genes that share disorders with PPY: view

No data available for UniProtKB/Swiss-Prot for PPY Gene

Publications for PPY Gene

  1. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell C.D. … Hirschhorn J.N. (Diabetes 2007) 3 23 48
  2. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7. (PMID: 3753985) Takeuchi T. … Shows T.B. (J. Clin. Invest. 1986) 2 3 4
  3. Structure of a precursor to human pancreatic polypeptide. (PMID: 6094571) Leiter A.B. … Goodman R.H. (J. Biol. Chem. 1984) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 48

Products for PPY Gene

Sources for PPY Gene

Back to Top

Content