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Aliases for PPY Gene

Aliases for PPY Gene

  • Pancreatic Polypeptide 2 3 4 5
  • Prepro-PP (Prepropancreatic Polypeptide) 2 3
  • Pancreatic Polypeptide Y 2 3
  • PNP 3 4
  • PP 3 4
  • Pancreatic Prohormone 3
  • Obinepitide 4

External Ids for PPY Gene

Previous GeneCards Identifiers for PPY Gene

  • GC17M041760
  • GC17M044195
  • GC17M042028
  • GC17M042493
  • GC17M039373
  • GC17M037782

Summaries for PPY Gene

Entrez Gene Summary for PPY Gene

  • This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for PPY Gene

PPY (Pancreatic Polypeptide) is a Protein Coding gene. Diseases associated with PPY include Obesity and Autonomic Nervous System Disease. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for PPY Gene

  • Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

  • The physiological role for the icosapeptide has not yet been elucidated.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPY Gene

Genomics for PPY Gene

Regulatory Elements for PPY Gene

Enhancers for PPY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F043983 1.2 FANTOM5 Ensembl ENCODE 12.4 -39.8 -39838 1.7 CREB3L1 MLX ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 SP3 SP5 ZHX2 TMEM101 MPP2 PPY ENSG00000221044 NAGS G6PC3 GC17P043983
GH17F043900 0.2 ENCODE 11.7 +43.6 43561 1.2 CBX3 PKNOX1 KLF17 THRB RFX5 GLIS2 FOS EGR2 ZNF263 SP3 PPY TMEM101 ENSG00000221044 MPP2 GC17P043880
GH17F044049 0.5 ENCODE 11.5 -105.7 -105658 1.2 ZNF121 SMARCA4 POLR2A G6PC3 TMEM101 ENSG00000221044 PPY PYY NAGS ASB16 GC17P044038 LSM12
GH17F044042 0.9 Ensembl ENCODE 10.8 -99.4 -99443 1.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 ZNF143 LSM12 G6PC3 PPY GC17P044038
GH17F044101 1 Ensembl ENCODE 10.8 -163.4 -163407 12.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ASB16-AS1 DHX8 HMGN1P29 LINC00910 ASB16 NAGS G6PC3 C17orf53 ENSG00000267002 ENSG00000267340
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPY on UCSC Golden Path with GeneCards custom track

Genomic Location for PPY Gene

Chromosome:
17
Start:
43,940,804 bp from pter
End:
43,944,248 bp from pter
Size:
3,445 bases
Orientation:
Minus strand

Genomic View for PPY Gene

Genes around PPY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPY Gene

Proteins for PPY Gene

  • Protein details for PPY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01298-PAHO_HUMAN
    Recommended name:
    Pancreatic prohormone
    Protein Accession:
    P01298

    Protein attributes for PPY Gene

    Size:
    95 amino acids
    Molecular mass:
    10445 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PPY Gene

    Alternative splice isoforms for PPY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPY Gene

Post-translational modifications for PPY Gene

No Post-translational modifications

Other Protein References for PPY Gene

Antibody Products

  • R&D Systems Antibodies for PPY (Pancreatic Polypeptide/PP)

No data available for DME Specific Peptides for PPY Gene

Domains & Families for PPY Gene

Gene Families for PPY Gene

Suggested Antigen Peptide Sequences for PPY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01298

UniProtKB/Swiss-Prot:

PAHO_HUMAN :
  • Belongs to the NPY family.
Family:
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PPY: view

Function for PPY Gene

Molecular function for PPY Gene

GENATLAS Biochemistry:
pancreatic polypeptide hormone precursor,expressed in the PP cells of the pancreas,regulator of pancreatic and gastrointestinal functions
UniProtKB/Swiss-Prot Function:
Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
UniProtKB/Swiss-Prot Function:
The physiological role for the icosapeptide has not yet been elucidated.

Gene Ontology (GO) - Molecular Function for PPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005102 receptor binding TAS 6373251
GO:0005179 hormone activity IEA,TAS 2997153
GO:0005184 neuropeptide hormone activity IBA --
genes like me logo Genes that share ontologies with PPY: view
genes like me logo Genes that share phenotypes with PPY: view

Animal Models for PPY Gene

MGI Knock Outs for PPY:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPY

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPY Gene

Localization for PPY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPY Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPY Gene COMPARTMENTS Subcellular localization image for PPY gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPY: view

Pathways & Interactions for PPY Gene

genes like me logo Genes that share pathways with PPY: view

SIGNOR curated interactions for PPY Gene

Activates:

Gene Ontology (GO) - Biological Process for PPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
GO:0007586 digestion TAS 6373251
GO:0007631 feeding behavior IBA --
GO:0009306 protein secretion TAS 2997153
genes like me logo Genes that share ontologies with PPY: view

Transcripts for PPY Gene

Unigene Clusters for PPY Gene

Pancreatic polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPY Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for PPY Gene

GeneLoc Exon Structure for
PPY
ECgene alternative splicing isoforms for
PPY

Expression for PPY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPY Gene

This gene is overexpressed in Pancreas (x52.4).

Protein differential expression in normal tissues from HIPED for PPY Gene

This gene is overexpressed in Islet of Langerhans (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPY Gene



Protein tissue co-expression partners for PPY Gene

NURSA nuclear receptor signaling pathways regulating expression of PPY Gene:

PPY

SOURCE GeneReport for Unigene cluster for PPY Gene:

Hs.558368
genes like me logo Genes that share expression patterns with PPY: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PPY Gene

Orthologs for PPY Gene

This gene was present in the common ancestor of mammals.

Orthologs for PPY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPY 34 35
  • 98.6 (n)
cow
(Bos Taurus)
Mammalia PPY 34 35
  • 86.88 (n)
dog
(Canis familiaris)
Mammalia PPY 34 35
  • 84.07 (n)
rat
(Rattus norvegicus)
Mammalia Ppy 34
  • 81.48 (n)
mouse
(Mus musculus)
Mammalia Ppy 34 16 35
  • 80.56 (n)
oppossum
(Monodelphis domestica)
Mammalia PPY 35
  • 76 (a)
OneToOne
Species where no ortholog for PPY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPY Gene

ENSEMBL:
Gene Tree for PPY (if available)
TreeFam:
Gene Tree for PPY (if available)

Paralogs for PPY Gene

(2) SIMAP similar genes for PPY Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPY Gene

genes like me logo Genes that share paralogs with PPY: view

No data available for Paralogs for PPY Gene

Variants for PPY Gene

Sequence variations from dbSNP and Humsavar for PPY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11275679 -- 43,940,413(+) TGTGC(-/CCCTGCCCCCAT)GCCAA downstream-variant-500B
rs113553334 -- 43,944,182(+) TCCAA(A/C)CCTAG upstream-variant-2KB, utr-variant-5-prime
rs113845875 -- 43,942,500(+) GGGCC(A/C/G)CTTTA intron-variant, upstream-variant-2KB
rs114128841 -- 43,941,920(+) TGTGA(G/T)TCCTG intron-variant
rs114373488 -- 43,944,011(+) CTTAC(A/G)TTCCA upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PPY Gene

Variant ID Type Subtype PubMed ID
esv993450 CNV deletion 20482838
nsv1146669 OTHER inversion 26484159
nsv833454 CNV loss 17160897

Variation tolerance for PPY Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPY Gene

Disorders for PPY Gene

MalaCards: The human disease database

(13) MalaCards diseases for PPY Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
autonomic nervous system disease
  • autonomic nervous system disorder
pancreatic cholera
  • excessive vasoactive intestinal peptide secretion [ambiguous]
pancreas disease
  • pancreatic diseases
pancreatic somatostatinoma
  • pancreatic delta cell somatostatin producing neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search PPY in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPY

Genetic Association Database (GAD)
PPY
Human Genome Epidemiology (HuGE) Navigator
PPY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPY
genes like me logo Genes that share disorders with PPY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPY Gene

Publications for PPY Gene

  1. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell C.D. … Hirschhorn J.N. (Diabetes 2007) 3 22 46 64
  2. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7. (PMID: 3753985) Takeuchi T. … Shows T.B. (J. Clin. Invest. 1986) 2 3 4 64
  3. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 46 64
  4. Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding. (PMID: 15966750) Lerch M. … Zerbe O. (Biochemistry 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PPY Gene

Sources for PPY Gene

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