Aliases for PPY Gene
External Ids for PPY Gene
Previous GeneCards Identifiers for PPY Gene
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for PPY Gene
PPY (Pancreatic Polypeptide) is a Protein Coding gene. Diseases associated with PPY include Pancreatic Somatostatinoma and Duodenal Somatostatinoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding.
UniProtKB/Swiss-Prot for PPY Gene
Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
The physiological role for the icosapeptide has not yet been elucidated.