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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPY Gene

protein-coding   GIFtS: 60
GCID: GC17M042028

Pancreatic Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pancreatic Polypeptide1 2 3     PP2 3
Pancreatic Polypeptide Y1 2     Pancreatic Prohormone2
Prepro-PP (Prepropancreatic Polypeptide)1 2     Obinepitide3
PNP2 3     

External Ids:    HGNC: 93271   Entrez Gene: 55392   Ensembl: ENSG000001088497   OMIM: 1677805   UniProtKB: P012983   

Export aliases for PPY gene to outside databases

Previous GC identifers: GC17M041760 GC17M044195 GC17M042493 GC17M039373 GC17M037782


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPY Gene:
This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor
in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and
an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions
and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced
in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of
this hormone in obese rodents has shown to decrease weight gain. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPY Gene: 
PPY (pancreatic polypeptide) is a protein-coding gene. Diseases associated with PPY include pancreatitis, and somatostatinoma, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include hormone activity and receptor binding.

UniProtKB/Swiss-Prot: PAHO_HUMAN, P01298
Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of
pancreatic and gastrointestinal functions
Function: The physiological role for the icosapeptide has not yet been elucidated




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPY gene promoter:
         MZF-1   NF-1   p53   Egr-1   Nkx2-2   SEF-1 (1)   STAT5A   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPY promoter sequence
   Search SABiosciences Chromatin IP Primers for PPY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

PPY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPY gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M042028:  view genomic region     (about GC identifiers)

Start:
42,018,172 bp from pter      End:
42,019,836 bp from pter
Size:
1,665 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAHO_HUMAN, P01298 (See protein sequence)
Recommended Name: Pancreatic prohormone precursor  
Size: 95 amino acids; 10445 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for PPY:
1TZ4 (3D)        1TZ5 (3D)    

Explore the universe of human proteins at neXtProt for PPY: NX_P01298

Explore proteomics data for PPY at MOPED 

PPY Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

PPY Protein Expression

REFSEQ proteins: NP_002713.1  
ENSEMBL proteins: 
 ENSP00000466546   ENSP00000225992   ENSP00000466009   ENSP00000465711  
Reactome Protein details: P01298
Human Recombinant Protein Products for PPY: 
EMD Millipore Purified and/or Recombinant PPY Protein
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec 
OriGene Custom Protein Services for PPY
GenScript Custom Purified and Recombinant Proteins Services for PPY
Novus Biologicals PPY Proteins
Novus Biologicals PPY Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

PPY for ontologies           About GeneDecksing



PPY Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of PPY
R&D Systems Antibodies for PPY (Pancreatic Polypeptide/PP)
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Novus Biologicals PPY Antibodies
Abcam antibodies for PPY
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ThermoFisher Antibody for PPY
LSBio Antibodies in human, mouse, rat for PPY 

Assay Products for PPY: 
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GenScript Custom Assay Services for PPY
Browse Enzo Life Sciences for kits & assays
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR001955 Pancreatic_hormone-like
 IPR020392 Pancreatic_hormone-like_CS
 IPR015480 Pancreatic_hormone

Graphical View of Domain Structure for InterPro Entry P01298

ProtoNet protein and cluster: P01298

1 Blocks protein domain: IPB001955 Pancreatic hormone

UniProtKB/Swiss-Prot: PAHO_HUMAN, P01298
Similarity: Belongs to the NPY family


PPY for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PAHO_HUMAN, P01298
Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of
pancreatic and gastrointestinal functions
Function: The physiological role for the icosapeptide has not yet been elucidated

     Genatlas biochemistry entry for PPY:
pancreatic polypeptide hormone precursor,expressed in the PP cells of the pancreas,regulator of pancreatic and
gastrointestinal functions

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding IEA--
GO:0005102receptor binding TAS6373251
GO:0005179hormone activity IEA--
     
PPY for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppy):
 behavior/neurological  growth/size  skeleton 

PPY for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Ppytm1Mws for PPY

   inGenious Targeting Laboratory - Custom generated mouse model solutions for PPY 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPY

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPY 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPY 

miRNA
Products:
    
miRTarBase miRNAs that target PPY:
hsa-mir-1 (MIRT003765)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPY
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PPY
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
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Gene Editing
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Clone
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OriGene clones in human, mouse for PPY (see all 7)
OriGene ORF clones in mouse, rat for PPY
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PPY (NM_002722)
Sino Biological Human cDNA Clone for PPY
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPY
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPY
Sirion Biotech Customized lentivirus for stable overexpression of PPY 
                     Customized lentivirus expression plasmids for stable overexpression of PPY 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPY


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PPY About                                                                                                See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.46
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



5/7        Reactome Pathways for PPY (see all 7)
    GPCR downstream signaling
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
G alpha (i) signalling events



PPY for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPY

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for PPY (P012983 ENSP000002259924) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
InteractantInteraction Details
GeneCardExternal ID(s)
NPY4RP503913, ENSP000003634314I2D: score=1 STRING: ENSP00000363431
ADCY2ENSP000003429524STRING: ENSP00000342952
APLNENSP000003054644STRING: ENSP00000305464
APPENSP000002849814STRING: ENSP00000284981
CASRENSP000002961544STRING: ENSP00000296154
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007586digestion TAS6373251
GO:0009306protein secretion TAS2997153

PPY for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPY (PAHO)

UniProtKB/Swiss-Prot: PAHO_HUMAN, P01298
Pharmaceutical: Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity.
Obinepitide is derived from pancreatic hormone by having Gln-63

Search CenterWatch for drugs/clinical trials and news about PPY / PAHO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPY gene: 
NM_002722.3  

Unigene Clusters for PPY:

Pancreatic polypeptide
Hs.558368  [show with all ESTs], Hs.744427  [show with all ESTs]
Unigene Representative Sequences: BI837116, BI835149
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000587926 ENST00000587070 ENST00000591703 ENST00000225992(uc002iep.3)
ENST00000591228 ENST00000587006
miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PPY
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Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for PPY
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPY
Clone
Products:
     
OriGene clones in human, mouse for PPY (see all 7)
OriGene ORF clones in mouse, rat for PPY
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PPY (NM_002722)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPY
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPY
Sirion Biotech Customized lentivirus for stable overexpression of PPY 
                     Customized lentivirus expression plasmids for stable overexpression of PPY 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for PPY
OriGene qSTAR qPCR primer pairs in human, mouse for PPY
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPY
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPY
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPY

Additional mRNA sequence: 

BC032225.2 BC040033.2 

10 DOTS entries:

DT.208492  DT.120937554  DT.100018387  DT.120937547  DT.120937543  DT.120937538  DT.120937550  DT.120937552 
DT.120937557  DT.95266767 

23 AceView cDNA sequences:

BM918317 BC040033 BC032225 X00491 NM_002722 AA835230 AA835232 AA921369 
BG191847 CA776075 M15788 BG213086 BG198472 BI838025 BI833623 AA844998 
AW583497 BG203646 BI832778 BI833992 BI834968 BI837116 BI835149 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PPY    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1:        -                 -     -                     
SP2:        -                 -                           
SP3:                          -     -                     
SP4:                          -                           
SP5:                                                      


ECgene alternative splicing isoforms for PPY

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPY expression in normal human tissues (normalized intensities)      PPY embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PPY Expression
About this image


PPY expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 3 entries
         Pancreatic Polypeptide Cells Islets of Langerhans
         Islets of Langerhans
         Beta-like cells ( Generation of beta cells through a definitive endoderm stage )
 
 Colon (Gastrointestinal Tract)

See PPY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPY

SOURCE GeneReport for Unigene clusters: Hs.558368 Hs.744427
    SABiosciences Expression via Pathway-Focused PCR Array including PPY: 
          Terminal Differentiation Markers in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPY

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for PPY gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ppy1 , 5 pancreatic polypeptide1, 5 80.56(n)1
75(a)1
  11 (65.48 cM)5
190641  NM_008918.11  NP_032944.11 
 1020999305 


ENSEMBL Gene Tree for PPY (if available)
TreeFam Gene Tree for PPY (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PPY gene
2 SIMAP similar genes for PPY using alignment to 3 protein entries:     PAHO_HUMAN (see all proteins):
PYY    NPY

PPY for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for PPY
PGOHUM00000237336


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/88 SNPs in PPY are shown (see all 88)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs112756791,2
C--42017781(+) TGTGC-/CCCTG 
 CCCCCAT
GCCAA
1 -- ds50010--------
rs580346611,2
C--42017954(+) TTGCT-/GAAGGACCA
T
/TGAAGGACCA
GAAGG
1 -- ds50010--------
rs797312851,2
C--42018184(+) GACTTA/GCTTTA 1 -- ut310--------
rs3718285881,2
C--42018213(+) AGGGAA/GCAAGC 1 -- ut310--------
rs2011836521,2
C--42018276(+) GAGTCG/ATAGGA 1 -- ut311Minor allele frequency- A:0.00EU 611
rs2314731,2
C,F,A,H--42018471(-) CCTGGG/AGCTGA 1 -- int117Minor allele frequency- A:0.33MN NS EA NA CSA WA 1390
rs72156981,2,4
C,F,A,H--42018541(+) CCCACT/CCCGAG 2 /E /G mis1 ese311Minor allele frequency- C:0.09NS EA WA NA 3808
rs1452799671,2
C,F--42018556(+) CCAGCG/ATGTCC 2 /T /M mis11Minor allele frequency- A:0.00NA 2606
rs1995809931,2
--42018618(+) CTGTGC/TCCAGG 1 -- int10--------
rs754745901,2
C,F--42018644(+) TTCATA/GTCTGC 1 -- int11Minor allele frequency- G:0.01WA 118

HapMap Linkage Disequilibrium report for PPY (42018172 - 42019836 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for PPY:    About this table     
Variant IDTypeSubtypePubMed ID
esv993450CNV Deletion20482838
nsv833454CNV Loss17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing PPY
DNA2.0 Custom Variant and Variant Library Synthesis for PPY

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 167780    OMIM disorders: --

20/25 diseases for PPY (see all 25):    About MalaCards
pancreatitis    somatostatinoma    wermer syndrome    vipoma
carcinoid syndrome    exocrine pancreatic insufficiency    anorexia nervosa    bulimia nervosa
hyperinsulinemic hypoglycemia    diabetic neuropathy    duodenal ulcer    hyperinsulinism
autonomic neuropathy    duodenitis    morbid obesity    obesity
hypoglycemia    prader-willi syndrome    diarrhea    multiple endocrine neoplasia

13 diseases from the University of Copenhagen DISEASES database for PPY:
Hypoglycemia     Autonomic neuropathy     Neuroendocrine tumor     Diabetes mellitus
Pancreatitis     Hyperinsulinemic hypoglycemia     Pancreatic cancer     Diarrhea
Duodenal ulcer     Hyperglycemia     Wermer syndrome     Exocrine pancreatic insufficiency
Pancreatic cholera

PPY for disorders           About GeneDecksing

Genetic Association Database (GAD): PPY
Human Genome Epidemiology (HuGE) Navigator: PPY (4 documents)

Export disorders for PPY gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PPY gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with PPY)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7. (PubMed id 3753985)1, 2, 3 Takeuchi T.... Shows T.B. (1986)
  2. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)1, 4, 9 Campbell C.D....Hirschhorn J.N. (2007)
  3. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PubMed id 17235527)1, 4 Siddiq A....Froguel P. (2007)
  4. Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding. (PubMed id 15966750)1, 2 Lerch M....Zerbe O. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Exons of the human pancreatic polypeptide gene define functional domains of the precursor. (PubMed id 2997153)1, 2 Leiter A.B.... Goodman R.H. (1985)
  7. Structure of a precursor to human pancreatic polypeptide. (PubMed id 6094571)1, 2 Leiter A.B.... Goodman R.H. (1984)
  8. Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor. (PubMed id 6366786)1, 2 Schwartz T.W.... Tager H.S. (1984)
  9. A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide. (PubMed id 6373251)1, 2 Boel E.... Fiil N.P. (1984)
  10. Liquid meal composition, postprandial satiety hormones , and perceived appetite and satiety in obese women during acute caloric restric tion. (PubMed id 23371976)1 Heden T.D....Kanaley J.A. (2013)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5539 HGNC: 9327 AceView: PPY Ensembl:ENSG00000108849 euGenes: HUgn5539
ECgene: PPY H-InvDB: PPY

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PPY Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PPY gene:
Search GeneIP for patents involving PPY

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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