Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPWD1 Gene

Aliases for PPWD1 Gene

  • Peptidylprolyl Isomerase Domain And WD Repeat Containing 1 2 3 5
  • EC 5.2.1.8 4 63
  • Spliceosome-Associated Cyclophilin 4
  • KIAA0073 4

External Ids for PPWD1 Gene

Previous GeneCards Identifiers for PPWD1 Gene

  • GC05P064895
  • GC05P061815
  • GC05P064859

Summaries for PPWD1 Gene

GeneCards Summary for PPWD1 Gene

PPWD1 (Peptidylprolyl Isomerase Domain And WD Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPWD1 Gene

  • Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPWD1 Gene

Genomics for PPWD1 Gene

Regulatory Elements for PPWD1 Gene

Promoters for PPWD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPWD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPWD1 Gene

Chromosome:
5
Start:
65,563,236 bp from pter
End:
65,587,549 bp from pter
Size:
24,314 bases
Orientation:
Plus strand

Genomic View for PPWD1 Gene

Genes around PPWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPWD1 Gene

Proteins for PPWD1 Gene

  • Protein details for PPWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BP3-PPWD1_HUMAN
    Recommended name:
    Peptidylprolyl isomerase domain and WD repeat-containing protein 1
    Protein Accession:
    Q96BP3
    Secondary Accessions:
    • B4DWR9
    • Q15002
    • Q7KZ89

    Protein attributes for PPWD1 Gene

    Size:
    646 amino acids
    Molecular mass:
    73575 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for PPWD1 Gene

    Alternative splice isoforms for PPWD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPWD1 Gene

Proteomics data for PPWD1 Gene at MOPED

Post-translational modifications for PPWD1 Gene

  • Ubiquitination at Lys 127
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PPWD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96BP3

UniProtKB/Swiss-Prot:

PPWD1_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
  • Contains 7 WD repeats.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PPWD1: view

Function for PPWD1 Gene

Molecular function for PPWD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPWD1 Gene

genes like me logo Genes that share phenotypes with PPWD1: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPWD1 Gene

Localization for PPWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPWD1 Gene

Nucleus. Note=Associated with spliceosomal complexes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPWD1 Gene COMPARTMENTS Subcellular localization image for PPWD1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PPWD1 Gene

Pathways & Interactions for PPWD1 Gene

SuperPathways for PPWD1 Gene

No Data Available

Interacting Proteins for PPWD1 Gene

Gene Ontology (GO) - Biological Process for PPWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPWD1: view

No data available for Pathways by source and SIGNOR curated interactions for PPWD1 Gene

Drugs & Compounds for PPWD1 Gene

No Compound Related Data Available

Transcripts for PPWD1 Gene

Unigene Clusters for PPWD1 Gene

Peptidylprolyl isomerase domain and WD repeat containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPWD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - - - - -
SP2: - -
SP3:
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8: - - - -
SP9: - - -
SP10: - -

Relevant External Links for PPWD1 Gene

GeneLoc Exon Structure for
PPWD1
ECgene alternative splicing isoforms for
PPWD1

Expression for PPWD1 Gene

mRNA expression in normal human tissues for PPWD1 Gene

Protein differential expression in normal tissues from HIPED for PPWD1 Gene

This gene is overexpressed in Lymph node (22.6), Peripheral blood mononuclear cells (10.8), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPWD1 Gene



SOURCE GeneReport for Unigene cluster for PPWD1 Gene Hs.121432

genes like me logo Genes that share expression patterns with PPWD1: view

Protein tissue co-expression partners for PPWD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPWD1 Gene

Orthologs for PPWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPWD1 36
  • 100 (a)
OneToOne
PPWD1 35
  • 99.64 (n)
  • 99.54 (a)
cow
(Bos Taurus)
Mammalia PPWD1 36
  • 98 (a)
OneToOne
PPWD1 35
  • 93.74 (n)
  • 97.67 (a)
dog
(Canis familiaris)
Mammalia PPWD1 35
  • 94.17 (n)
  • 97.21 (a)
PPWD1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppwd1 16
Ppwd1 35
  • 90.51 (n)
  • 97.21 (a)
Ppwd1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPWD1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPWD1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppwd1 35
  • 90.51 (n)
  • 96.59 (a)
chicken
(Gallus gallus)
Aves PPWD1 35
  • 82.77 (n)
  • 92.11 (a)
PPWD1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPWD1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12731 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppwd1 35
  • 76.63 (n)
  • 87.52 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14630 35
ppwd1 35
  • 74.61 (n)
  • 85.6 (a)
ppwd1 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008660 35
  • 60.7 (n)
  • 62.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3511 36
  • 58 (a)
OneToOne
CG3511 35
  • 59.34 (n)
  • 61.16 (a)
worm
(Caenorhabditis elegans)
Secernentea cyn-16 36
  • 14 (a)
ManyToMany
cyn-15 35
  • 55.46 (n)
  • 50.17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP71 35
  • 57.28 (n)
  • 55.02 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5002 35
rice
(Oryza sativa)
Liliopsida Os.13002 35
wheat
(Triticum aestivum)
Liliopsida Ta.4166 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09819 35
  • 51.28 (n)
  • 49.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp9 35
  • 51.74 (n)
  • 42.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6715 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1069 36
  • 57 (a)
OneToOne
Species with no ortholog for PPWD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPWD1 Gene

ENSEMBL:
Gene Tree for PPWD1 (if available)
TreeFam:
Gene Tree for PPWD1 (if available)

Paralogs for PPWD1 Gene

Paralogs for PPWD1 Gene

genes like me logo Genes that share paralogs with PPWD1: view

Variants for PPWD1 Gene

Sequence variations from dbSNP and Humsavar for PPWD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs27141 -- 65,586,109(+) AGGCC(A/G)TACAC reference, synonymous-codon
rs27142 -- 65,588,028(+) AATAC(A/C)TGCCA downstream-variant-500B
rs149208 -- 65,569,578(+) ATACT(A/G)AGTGA intron-variant
rs149512 -- 65,569,519(-) TTTTT(A/T)AAAAA intron-variant
rs149513 -- 65,582,248(+) GGCCT(G/T)GAGAA intron-variant

Variation tolerance for PPWD1 Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPWD1 Gene

HapMap Linkage Disequilibrium report
PPWD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPWD1 Gene

Disorders for PPWD1 Gene

Relevant External Links for PPWD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPWD1

No disorders were found for PPWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPWD1 Gene

Publications for PPWD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for PPWD1 Gene

Sources for PPWD1 Gene

Back to Top

Content