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PPWD1 Gene

protein-coding   GIFtS: 50
GCID: GC05P064859

Peptidylprolyl Isomerase Domain And WD Repeat Containing...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase Domain And WD Repeat Containing 11 2
Spliceosome-Associated Cyclophilin2 3
EC 5.2.1.83 8
Peptidylprolyl Isomerase Domain And WD Repeat-Containing Protein 12
KIAA00733

External Ids:    HGNC: 289541   Entrez Gene: 233982   Ensembl: ENSG000001135937   UniProtKB: Q96BP33   

Export aliases for PPWD1 gene to outside databases

Previous GC identifers: GC05P064895 GC05P061815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPWD1 Gene:
PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1) is a protein-coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPWD1_HUMAN, Q96BP3
Function: Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the
cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPWD1 gene promoter:
         E2F   E2F-1   AML1a   POU2F1   Pbx1a   POU2F1a   Cart-1   PPAR-gamma2   LCR-F1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPWD1 promoter sequence
   Search Chromatin IP Primers for PPWD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPWD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

PPWD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPWD1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P064859:  view genomic region     (about GC identifiers)

Start:
64,859,063 bp from pter      End:
64,883,376 bp from pter
Size:
24,314 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PPWD1_HUMAN, Q96BP3 (See protein sequence)
Recommended Name: Peptidylprolyl isomerase domain and WD repeat-containing protein 1  
Size: 646 amino acids; 73575 Da
Subunit: Identified in the spliceosome C complex
1 PDB 3D structure from and Proteopedia for PPWD1:
2A2N (3D)    
Secondary accessions: Q15002 Q7KZ89

Explore the universe of human proteins at neXtProt for PPWD1: NX_Q96BP3

Explore proteomics data for PPWD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPWD1 (Q96BP3) (see all 13)
     TLRHDRP  PKTVENF  SYMHRDV  RHDRPYT 


    See PPWD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265855.1  NP_001265856.1  NP_001265858.1  NP_056157.1  

    ENSEMBL proteins: 
     ENSP00000261308   ENSP00000427642   ENSP00000424519   ENSP00000423486   ENSP00000425390  
     ENSP00000427054   ENSP00000423234   ENSP00000421595   ENSP00000442371   ENSP00000444496  

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    antibodies-online proteins for PPWD1 (3 products) 

     
    antibodies-online peptides for PPWD1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96BP3

    ProtoNet protein and cluster: Q96BP3

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPWD1_HUMAN, Q96BP3
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain
    Similarity: Contains 4 WD repeats


    Find genes that share domains with PPWD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPWD1_HUMAN, Q96BP3
    Function: Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the
    cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PPWD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPWD1:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PPWD1

    miRNA
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    miRTarBase miRNAs that target PPWD1:
    hsa-mir-361-3p (MIRT038269)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPWD1_HUMAN, Q96BP3: Nucleus. Note=Associated with spliceosomal complexes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with PPWD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPWD1
    Interactions:

        Search GeneGlobe Interaction Network for PPWD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for PPWD1 (ENSP000002613084) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG4ENSP000003157754STRING: ENSP00000315775
    SGSM3ENSP000002489294STRING: ENSP00000248929
    CDC45ENSP000002632014STRING: ENSP00000263201
    EIF2B5ENSP000002737834STRING: ENSP00000273783
    ACOX1ENSP000002932174STRING: ENSP00000293217
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006457protein folding IEA--

    Find genes that share ontologies with PPWD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPWD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPWD1 gene (4 alternative transcripts): 
    NM_001278926.1  NM_001278927.1  NM_001278929.1  NM_015342.3  

    Unigene Cluster for PPWD1:

    Peptidylprolyl isomerase domain and WD repeat containing 1
    Hs.121432  [show with all ESTs]
    Unigene Representative Sequence: NR_046348
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508982 ENST00000261308(uc003jtv.4 uc011cqv.2 uc011cqw.2)
    ENST00000503435 ENST00000515447 ENST00000510930 ENST00000511908 ENST00000502703
    ENST00000505380 ENST00000507608 ENST00000514172 ENST00000511334 ENST00000515151
    ENST00000513773 ENST00000535264 ENST00000538977
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    Predesigned siRNA for gene silencing in human, mouse, rat PPWD1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPWD1
    Addgene plasmids for PPWD1 
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    OriGene qSTAR qPCR primer pairs in human, mouse for PPWD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPWD1
      QuantiTect SYBR Green Assays in human, mouse, rat PPWD1
      QuantiFast Probe-based Assays in human, mouse, rat PPWD1

    Additional mRNA sequence: 

    AK025679.1 AK298175.1 AK300022.1 AK301654.1 BC015385.1 D38552.1 NR_046348.1 NR_046349.1 
    NR_046350.1 

    18 DOTS entries:

    DT.100776568  DT.454236  DT.86854800  DT.91910263  DT.309147  DT.100720546  DT.114937  DT.40197331 
    DT.114939  DT.120886138  DT.65286163  DT.95217220  DT.120886156  DT.86854801  DT.95076189  DT.95180078 
    DT.99998967  DT.95093982 

    Selected AceView cDNA sequences (see all 160):

    BM918338 CB130732 AA297828 BX397845 BM669378 AA029327 F30025 D38552 
    AA432386 CK904018 AW377767 AW770630 CR617762 AI377278 NM_015342 BE041527 
    AU136405 AA298473 AW105155 BC015385 CB122022 AA431396 AA371384 BM480211 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPWD1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:        -     -                 -     -     -                                               -                 -           -                                 
    SP2:                                -           -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                            -     -                                                         
    SP5:                                                                                            -                 -                                             


    ECgene alternative splicing isoforms for PPWD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPWD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAAGAT
    PPWD1 Expression
    About this image


    PPWD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PPWD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPWD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121432
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPWD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPWD1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppwd11 , 5 peptidylprolyl isomerase domain and WD repeat containing more1, 5 90.51(n)1
    97.21(a)1
      13 (56.39 cM)5
    2388311  NM_172807.41  NP_766395.21 
     1042051215 
    chicken
    (Gallus gallus)
    Aves PPWD11 peptidylprolyl isomerase domain and WD repeat containing more 82.77(n)
    92.11(a)
      427163  XM_424751.4  XP_424751.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPWD16
    peptidylprolyl isomerase domain and WD repeat cont...
    81(a)
    1 ↔ 1
    2(10681307-10698041)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127312 Xenopus laevis transcribed sequence with weak similarity more 78.08(n)    BU910802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.146302 Transcribed sequence with weak similarity to protein more 79.51(n)    BQ133488.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35111 CG3511 59.34(n)
    61.16(a)
      37926  NM_138091.2  NP_611935.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cyn-151 cyn-15 55.46(n)
    50.17(a)
      173225  NM_060977.3  NP_493378.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP711 CYP71 57.28(n)
    55.02(a)
      823585  NM_114328.3  NP_190046.2 
    rice
    (Oryza sativa)
    Liliopsida Os.130022 Oryza sativa (japonica cultivar-group) mRNA for hypothetical more 74.18(n)    AK111941.1 


    ENSEMBL Gene Tree for PPWD1 (if available)
    TreeFam Gene Tree for PPWD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPWD1 gene
    PPIH2  PPIC2  PPIB2  CWC272  PPIL42  PPIL22  PPIL32  PPIL12  
    17 SIMAP similar genes for PPWD1 using alignment to 10 protein entries:     PPWD1_HUMAN (see all proteins):
    PPIL1    PPIF    PPIL3    PPIB    PPIG    PPIA
    PPIAL4D    PPID    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4G
    PPIC    PPIH    LOC402252    PPIE    NKTR

    Find genes that share paralogs with PPWD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPWD1 (see all 521)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830612441,2
    --64861062(+) TTTTTG/TTTTCA 4 -- int10--------
    rs1870158221,2
    --64861169(+) GCAAGC/TTCTTT 4 -- int10--------
    rs125162291,2
    C,F,H--64861271(+) ATAACG/CGAGAC 4 -- int19Minor allele frequency- C:0.23EA NS NA CSA WA 634
    rs1906479241,2
    --64861303(+) AAAATC/TTTTCC 4 -- int10--------
    rs1831802891,2
    --64861445(+) CCAACA/GTGGTG 4 -- int10--------
    rs1408431731,2
    --64861510(+) CACACC/TTATAA 4 -- int10--------
    rs1498039791,2
    --64861516(+) TATAAC/TCTCAG 4 -- int10--------
    rs350806761,2
    C--64861635(+) AAAAA-/A/AA  
            
    AAAAA
    4 -- int12NA 4
    rs1167055541,2
    C,F--64861709(+) ATAGAA/GTGTTA 4 -- int11Minor allele frequency- G:0.05WA 118
    rs3533121,2
    F,H--64861810(+) GACATT/GGGACT 4 -- int15Minor allele frequency- G:0.01NS EA NA 392

    HapMap Linkage Disequilibrium report for PPWD1 (64859063 - 64883376 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PPWD1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPWD1
    DNA2.0 Custom Variant and Variant Library Synthesis for PPWD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPWD1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with PPWD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N.... Tabata S. (DNA Res. 1994)
    2. The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1). (PubMed id 18397323)1, 2 Davis T.L.... Dhe-Paganon S. (FEBS J. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23398 HGNC: 28954 AceView: KIAA0073 Ensembl:ENSG00000113593 euGenes: HUgn23398
    ECgene: PPWD1 H-InvDB: PPWD1

    (According to HUGE)
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    HUGE: KIAA0073

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPWD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPWD1 gene:
    Search GeneIP for patents involving PPWD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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