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Aliases for PPWD1 Gene

Aliases for PPWD1 Gene

  • Peptidylprolyl Isomerase Domain And WD Repeat Containing 1 2 3
  • EC 5.2.1.8 4 63
  • Spliceosome-Associated Cyclophilin 4
  • KIAA0073 4

External Ids for PPWD1 Gene

Previous GeneCards Identifiers for PPWD1 Gene

  • GC05P064895
  • GC05P061815
  • GC05P064859

Summaries for PPWD1 Gene

GeneCards Summary for PPWD1 Gene

PPWD1 (Peptidylprolyl Isomerase Domain And WD Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPWD1 Gene

  • Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPWD1 Gene

Genomics for PPWD1 Gene

Regulatory Elements for PPWD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPWD1 Gene

Start:
65,563,236 bp from pter
End:
65,587,549 bp from pter
Size:
24,314 bases
Orientation:
Plus strand

Genomic View for PPWD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPWD1 Gene

Proteins for PPWD1 Gene

  • Protein details for PPWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BP3-PPWD1_HUMAN
    Recommended name:
    Peptidylprolyl isomerase domain and WD repeat-containing protein 1
    Protein Accession:
    Q96BP3
    Secondary Accessions:
    • B4DWR9
    • Q15002
    • Q7KZ89

    Protein attributes for PPWD1 Gene

    Size:
    646 amino acids
    Molecular mass:
    73575 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for PPWD1 Gene

    Alternative splice isoforms for PPWD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPWD1 Gene

Proteomics data for PPWD1 Gene at MOPED

Post-translational modifications for PPWD1 Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

Domains for PPWD1 Gene

Gene Families for PPWD1 Gene

HGNC:
  • WDR :WD repeat domain containing

Graphical View of Domain Structure for InterPro Entry

Q96BP3

UniProtKB/Swiss-Prot:

PPWD1_HUMAN :
  • Q96BP3
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PPWD1: view

Function for PPWD1 Gene

Molecular function for PPWD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for PPWD1 Gene

Gene Ontology (GO) - Molecular Function for PPWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PPWD1: view

Phenotypes for PPWD1 Gene

GenomeRNAi human phenotypes for PPWD1:
genes like me logo Genes that share phenotypes with PPWD1: view

Animal Model Products

CRISPR Products

miRNA for PPWD1 Gene

miRTarBase miRNAs that target PPWD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPWD1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPWD1 Gene

Localization for PPWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPWD1 Gene

Nucleus. Note=Associated with spliceosomal complexes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPWD1 Gene COMPARTMENTS Subcellular localization image for PPWD1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPWD1: view

Pathways for PPWD1 Gene

SuperPathways for PPWD1 Gene

No Data Available

Interacting Proteins for PPWD1 Gene

Gene Ontology (GO) - Biological Process for PPWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPWD1: view

No data available for Pathways by source for PPWD1 Gene

Transcripts for PPWD1 Gene

Unigene Clusters for PPWD1 Gene

Peptidylprolyl isomerase domain and WD repeat containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPWD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPWD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - - - - -
SP2: - -
SP3:
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8: - - - -
SP9: - - -
SP10: - -

Relevant External Links for PPWD1 Gene

GeneLoc Exon Structure for
PPWD1
ECgene alternative splicing isoforms for
PPWD1

Expression for PPWD1 Gene

mRNA expression in normal human tissues for PPWD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPWD1 Gene

SOURCE GeneReport for Unigene cluster for PPWD1 Gene Hs.121432

genes like me logo Genes that share expressions with PPWD1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPWD1 Gene

Orthologs for PPWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPWD1 35
  • 99.64 (n)
  • 99.54 (a)
PPWD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPWD1 35
  • 93.74 (n)
  • 97.67 (a)
PPWD1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPWD1 35
  • 94.17 (n)
  • 97.21 (a)
PPWD1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppwd1 35
  • 90.51 (n)
  • 97.21 (a)
Ppwd1 16
Ppwd1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPWD1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPWD1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppwd1 35
  • 90.51 (n)
  • 96.59 (a)
chicken
(Gallus gallus)
Aves PPWD1 35
  • 82.77 (n)
  • 92.11 (a)
PPWD1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPWD1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12731 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppwd1 35
  • 76.63 (n)
  • 87.52 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14630 35
ppwd1 35
  • 74.61 (n)
  • 85.6 (a)
ppwd1 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008660 35
  • 60.7 (n)
  • 62.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3511 35
  • 59.34 (n)
  • 61.16 (a)
CG3511 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cyn-15 35
  • 55.46 (n)
  • 50.17 (a)
cyn-16 36
  • 14 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP71 35
  • 57.28 (n)
  • 55.02 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5002 35
rice
(Oryza sativa)
Liliopsida Os.13002 35
wheat
(Triticum aestivum)
Liliopsida Ta.4166 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09819 35
  • 51.28 (n)
  • 49.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp9 35
  • 51.74 (n)
  • 42.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6715 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1069 36
  • 57 (a)
OneToOne
Species with no ortholog for PPWD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPWD1 Gene

ENSEMBL:
Gene Tree for PPWD1 (if available)
TreeFam:
Gene Tree for PPWD1 (if available)

Paralogs for PPWD1 Gene

Paralogs for PPWD1 Gene

genes like me logo Genes that share paralogs with PPWD1: view

Variants for PPWD1 Gene

Sequence variations from dbSNP and Humsavar for PPWD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27139 -- 65,585,354(+) TAAAG(G/T)GTCAT intron-variant
rs27140 -- 65,585,751(+) TATTT(A/G)GGTTA intron-variant
rs27141 -- 65,586,109(+) AGGCC(A/G)TACAC reference, synonymous-codon
rs27142 -- 65,588,028(+) AATAC(A/C)TGCCA downstream-variant-500B
rs36223 -- 65,570,148(+) TACAG(C/T)GAAGC intron-variant

Relevant External Links for PPWD1 Gene

HapMap Linkage Disequilibrium report
PPWD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPWD1 Gene

Disorders for PPWD1 Gene

No disorders were found for PPWD1 Gene.

No data available for UniProtKB/Swiss-Prot for PPWD1 Gene

Publications for PPWD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1). (PMID: 18397323) Davis T.L. … Dhe-Paganon S. (FEBS J. 2008) 3 4

Products for PPWD1 Gene

  • Addgene plasmids for PPWD1

Sources for PPWD1 Gene

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