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Aliases for PPTC7 Gene

Aliases for PPTC7 Gene

  • PTC7 Protein Phosphatase Homolog 2 3 5
  • EC 4 61
  • TA-PP2C 3 4
  • TAPP2C 3 4
  • PTC7 Protein Phosphatase Homolog (S. Cerevisiae) 2
  • T-Cell Activation Protein Phosphatase 2C-Like 4
  • T Cell Activation Protein Phosphatase 2C 2
  • T-Cell Activation Protein Phosphatase 2C 4
  • Protein Phosphatase PTC7 Homolog 3

External Ids for PPTC7 Gene

Previous GeneCards Identifiers for PPTC7 Gene

  • GC12M109456
  • GC12M110972
  • GC12M107991

Summaries for PPTC7 Gene

GeneCards Summary for PPTC7 Gene

PPTC7 (PTC7 Protein Phosphatase Homolog) is a Protein Coding gene. Among its related pathways are Regulation of CFTR activity (norm and CF) and Development Dopamine D2 receptor transactivation of EGFR. GO annotations related to this gene include phosphoprotein phosphatase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPTC7 Gene

Genomics for PPTC7 Gene

Regulatory Elements for PPTC7 Gene

Enhancers for PPTC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F110554 1.2 Ensembl ENCODE 13 +27.3 27320 2.4 USF1 MAX CTBP1 GATA3 SCRT2 SCRT1 SMARCC1 L3MBTL2 HLF BHLHE40 GPN3 PPTC7 TCTN1 FAM216A VPS29
GH12F110552 0.7 ENCODE 13 +30.8 30820 0.2 SOX13 ELF3 CTCF ARID4B MAX CEBPG RAD21 TEAD3 ZNF143 SMC3 PPTC7 TCTN1 VPS29
GH12F110553 0.2 ENCODE 13 +31.1 31090 0.2 GATAD2A ELF3 CTCF CEBPB REST RAD21 TEAD3 ZGPAT ZNF143 ZNF580 PPTC7 TCTN1 VPS29
GH12F110589 1.1 FANTOM5 Ensembl ENCODE 10.5 -7.9 -7933 3.5 PKNOX1 ZFP64 ARID4B DMAP1 YY1 ZNF121 SP5 REST TBX21 PPARG ARPC3 TCTN1 PPTC7 ANAPC7 FAM216A HVCN1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPTC7 on UCSC Golden Path with GeneCards custom track

Promoters for PPTC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PPTC7 Gene

110,533,245 bp from pter
110,583,320 bp from pter
50,076 bases
Minus strand

Genomic View for PPTC7 Gene

Genes around PPTC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPTC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPTC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPTC7 Gene

Proteins for PPTC7 Gene

  • Protein details for PPTC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase PTC7 homolog
    Protein Accession:
    Secondary Accessions:
    • B3KWC5
    • Q68DZ7
    • Q6UY82

    Protein attributes for PPTC7 Gene

    304 amino acids
    Molecular mass:
    32646 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for PPTC7 Gene

Post-translational modifications for PPTC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPTC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPTC7 Gene

Protein Domains for PPTC7 Gene


Suggested Antigen Peptide Sequences for PPTC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPTC7: view

No data available for Gene Families for PPTC7 Gene

Function for PPTC7 Gene

Molecular function for PPTC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Induction:
Up-regulated during lymphocyte activation.

Enzyme Numbers (IUBMB) for PPTC7 Gene

Gene Ontology (GO) - Molecular Function for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPTC7: view
genes like me logo Genes that share phenotypes with PPTC7: view

Animal Model Products

miRNA for PPTC7 Gene

miRTarBase miRNAs that target PPTC7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPTC7 Gene

Localization for PPTC7 Gene

Subcellular locations from

Jensen Localization Image for PPTC7 Gene COMPARTMENTS Subcellular localization image for PPTC7 gene
Compartment Confidence
cytosol 3
mitochondrion 3
plasma membrane 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
genes like me logo Genes that share ontologies with PPTC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPTC7 Gene

Pathways & Interactions for PPTC7 Gene

genes like me logo Genes that share pathways with PPTC7: view

Pathways by source for PPTC7 Gene

Gene Ontology (GO) - Biological Process for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA --
genes like me logo Genes that share ontologies with PPTC7: view

No data available for SIGNOR curated interactions for PPTC7 Gene

Drugs & Compounds for PPTC7 Gene

(4) Drugs for PPTC7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
Magnesium Nutra 0
genes like me logo Genes that share compounds with PPTC7: view

Transcripts for PPTC7 Gene

mRNA/cDNA for PPTC7 Gene

Unigene Clusters for PPTC7 Gene

PTC7 protein phosphatase homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPTC7 Gene

No ASD Table

Relevant External Links for PPTC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPTC7 Gene

mRNA expression in normal human tissues for PPTC7 Gene

mRNA differential expression in normal tissues according to GTEx for PPTC7 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

Protein differential expression in normal tissues from HIPED for PPTC7 Gene

This gene is overexpressed in Heart (33.7) and CD8 Tcells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPTC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPTC7 Gene:


SOURCE GeneReport for Unigene cluster for PPTC7 Gene:

genes like me logo Genes that share expression patterns with PPTC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PPTC7 Gene

Orthologs for PPTC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPTC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPTC7 34 35
  • 99.56 (n)
(Ornithorhynchus anatinus)
Mammalia PPTC7 35
  • 99 (a)
(Monodelphis domestica)
Mammalia PPTC7 35
  • 96 (a)
(Canis familiaris)
Mammalia PPTC7 34 35
  • 94.08 (n)
(Bos Taurus)
Mammalia PPTC7 34 35
  • 93.75 (n)
(Mus musculus)
Mammalia Pptc7 34 16 35
  • 89.14 (n)
(Rattus norvegicus)
Mammalia Pptc7 34
  • 89.04 (n)
(Gallus gallus)
Aves PPTC7 34 35
  • 83.61 (n)
(Anolis carolinensis)
Reptilia PPTC7 35
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pptc7 34
  • 79.12 (n)
(Danio rerio)
Actinopterygii pptc7a 35
  • 94 (a)
pptc7b 34 35
  • 76.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12091 34 35
  • 56.82 (n)
fig 35
  • 39 (a)
CG15035 35
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002141 34
  • 52.99 (n)
(Caenorhabditis elegans)
Secernentea W09D10.4 34 35
  • 51.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC7 34 35 37
  • 46.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13134g 34
  • 45.64 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16580 34
  • 48.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2135 35
  • 64 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00958 34
  • 48.02 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes azr1 34
  • 44.88 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2504 34
Species where no ortholog for PPTC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPTC7 Gene

Gene Tree for PPTC7 (if available)
Gene Tree for PPTC7 (if available)

Paralogs for PPTC7 Gene

No data available for Paralogs for PPTC7 Gene

Variants for PPTC7 Gene

Sequence variations from dbSNP and Humsavar for PPTC7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10622869 -- 110,577,721(+) TTTAA(-/CTAA)GCTTA intron-variant
rs10849900 -- 110,537,085(+) TCATC(C/T)GGCTT nc-transcript-variant, reference, synonymous-codon
rs11065659 -- 110,536,794(+) ACATC(C/G)AGAAA nc-transcript-variant, utr-variant-3-prime
rs11065660 -- 110,537,174(+) TACTA(A/G)GAGAC intron-variant
rs11065661 -- 110,537,314(+) AAAAT(C/G)TTCCC intron-variant

Variation tolerance for PPTC7 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPTC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPTC7 Gene

Disorders for PPTC7 Gene

Relevant External Links for PPTC7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPTC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPTC7 Gene

Publications for PPTC7 Gene

  1. T lymphocyte activation gene identification by coregulated expression on DNA microarrays. (PMID: 15177553) Mao M. … Linsley P.S. (Genomics 2004) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64

Products for PPTC7 Gene

Sources for PPTC7 Gene

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