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Aliases for PPTC7 Gene

Aliases for PPTC7 Gene

  • PTC7 Protein Phosphatase Homolog 2 3
  • EC 3.1.3.16 4 63
  • TA-PP2C 3 4
  • TAPP2C 3 4
  • PTC7 Protein Phosphatase Homolog (S. Cerevisiae) 2
  • T-Cell Activation Protein Phosphatase 2C-Like 4
  • T Cell Activation Protein Phosphatase 2C 2
  • T-Cell Activation Protein Phosphatase 2C 4

External Ids for PPTC7 Gene

Previous GeneCards Identifiers for PPTC7 Gene

  • GC12M109456
  • GC12M110972
  • GC12M107991

Summaries for PPTC7 Gene

GeneCards Summary for PPTC7 Gene

PPTC7 (PTC7 Protein Phosphatase Homolog) is a Protein Coding gene. Among its related pathways are Regulation of CFTR activity (norm and CF) and Development Dopamine D2 receptor transactivation of EGFR. GO annotations related to this gene include phosphoprotein phosphatase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPTC7 Gene

Genomics for PPTC7 Gene

Regulatory Elements for PPTC7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPTC7 Gene

Chromosome:
12
Start:
110,533,245 bp from pter
End:
110,583,320 bp from pter
Size:
50,076 bases
Orientation:
Minus strand

Genomic View for PPTC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPTC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPTC7 Gene

Proteins for PPTC7 Gene

  • Protein details for PPTC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI37-PPTC7_HUMAN
    Recommended name:
    Protein phosphatase PTC7 homolog
    Protein Accession:
    Q8NI37
    Secondary Accessions:
    • B3KWC5
    • Q68DZ7
    • Q6UY82

    Protein attributes for PPTC7 Gene

    Size:
    304 amino acids
    Molecular mass:
    32646 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for PPTC7 Gene

Proteomics data for PPTC7 Gene at MOPED

Post-translational modifications for PPTC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPTC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPTC7 Gene

Protein Domains for PPTC7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPTC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI37

UniProtKB/Swiss-Prot:

PPTC7_HUMAN :
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPTC7: view

No data available for Gene Families for PPTC7 Gene

Function for PPTC7 Gene

Molecular function for PPTC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Induction:
Up-regulated during lymphocyte activation.

Enzyme Numbers (IUBMB) for PPTC7 Gene

Gene Ontology (GO) - Molecular Function for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPTC7: view
genes like me logo Genes that share phenotypes with PPTC7: view

Animal Model Products

miRNA for PPTC7 Gene

miRTarBase miRNAs that target PPTC7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPTC7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPTC7 Gene

Localization for PPTC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPTC7 Gene COMPARTMENTS Subcellular localization image for PPTC7 gene
Compartment Confidence
cytosol 2
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PPTC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPTC7 Gene

Pathways & Interactions for PPTC7 Gene

genes like me logo Genes that share pathways with PPTC7: view

Pathways by source for PPTC7 Gene

Gene Ontology (GO) - Biological Process for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
genes like me logo Genes that share ontologies with PPTC7: view

No data available for SIGNOR curated interactions for PPTC7 Gene

Drugs & Compounds for PPTC7 Gene

(2) Drugs for PPTC7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 30
Magnesium Nutra 0

(2) Additional Compounds for PPTC7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PPTC7: view

Transcripts for PPTC7 Gene

mRNA/cDNA for PPTC7 Gene

Unigene Clusters for PPTC7 Gene

PTC7 protein phosphatase homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPTC7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPTC7 Gene

No ASD Table

Relevant External Links for PPTC7 Gene

GeneLoc Exon Structure for
PPTC7
ECgene alternative splicing isoforms for
PPTC7

Expression for PPTC7 Gene

mRNA expression in normal human tissues for PPTC7 Gene

mRNA differential expression in normal tissues according to GTEx for PPTC7 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

Protein differential expression in normal tissues from HIPED for PPTC7 Gene

This gene is overexpressed in Heart (33.7) and CD8 Tcells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPTC7 Gene



SOURCE GeneReport for Unigene cluster for PPTC7 Gene Hs.13854

genes like me logo Genes that share expression patterns with PPTC7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPTC7 Gene

Orthologs for PPTC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPTC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPTC7 35
  • 93.75 (n)
  • 100 (a)
PPTC7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPTC7 35
  • 94.08 (n)
  • 100 (a)
PPTC7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pptc7 35
  • 89.14 (n)
  • 98.36 (a)
Pptc7 16
Pptc7 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPTC7 35
  • 99.56 (n)
  • 100 (a)
PPTC7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pptc7 35
  • 89.04 (n)
  • 98.68 (a)
oppossum
(Monodelphis domestica)
Mammalia PPTC7 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPTC7 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPTC7 35
  • 83.61 (n)
  • 96.63 (a)
PPTC7 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPTC7 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pptc7 35
  • 79.12 (n)
  • 92.93 (a)
zebrafish
(Danio rerio)
Actinopterygii pptc7b 35
  • 76.54 (n)
  • 90.91 (a)
pptc7a 36
  • 94 (a)
OneToMany
pptc7b 36
  • 91 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002141 35
  • 52.99 (n)
  • 48.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12091 35
  • 56.82 (n)
  • 55.3 (a)
CG12091 36
  • 49 (a)
OneToMany
CG15035 36
  • 37 (a)
OneToMany
fig 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W09D10.4 35
  • 51.16 (n)
  • 47.67 (a)
W09D10.4 36
  • 39 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13134g 35
  • 45.64 (n)
  • 33.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC7 35
  • 46.3 (n)
  • 39.32 (a)
PTC7 36
  • 28 (a)
OneToOne
PTC7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16580 35
  • 48.34 (n)
  • 43.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2504 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00958 35
  • 48.02 (n)
  • 42.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes azr1 35
  • 44.88 (n)
  • 37.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2135 36
  • 64 (a)
OneToOne
Species with no ortholog for PPTC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPTC7 Gene

ENSEMBL:
Gene Tree for PPTC7 (if available)
TreeFam:
Gene Tree for PPTC7 (if available)

Paralogs for PPTC7 Gene

No data available for Paralogs for PPTC7 Gene

Variants for PPTC7 Gene

Sequence variations from dbSNP and Humsavar for PPTC7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10075 -- 110,533,637(+) TGATA(C/T)AGTTT utr-variant-3-prime
rs957394 -- 110,545,867(+) GCTGA(A/G)AGGGG intron-variant
rs957395 -- 110,545,924(+) ATTGA(A/G)AGCTG reference, synonymous-codon
rs1265742 -- 110,577,316(-) ATTTT(C/T)TTTTC intron-variant
rs1265743 -- 110,574,962(-) AAGTT(A/T)AAAAA intron-variant

Variation tolerance for PPTC7 Gene

Residual Variation Intolerance Score: 41.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPTC7 Gene

HapMap Linkage Disequilibrium report
PPTC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPTC7 Gene

Disorders for PPTC7 Gene

Relevant External Links for PPTC7

Genetic Association Database (GAD)
PPTC7
Human Genome Epidemiology (HuGE) Navigator
PPTC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPTC7
genes like me logo Genes that share disorders with PPTC7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPTC7 Gene

Publications for PPTC7 Gene

  1. T lymphocyte activation gene identification by coregulated expression on DNA microarrays. (PMID: 15177553) Mao M. … Linsley P.S. (Genomics 2004) 2 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 67
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 67
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for PPTC7 Gene

Sources for PPTC7 Gene

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