Aliases for PPT2 Gene
External Ids for PPT2 Gene
Previous GeneCards Identifiers for PPT2 Gene
This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for PPT2 Gene
PPT2 (Palmitoyl-Protein Thioesterase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Lysosome. GO annotations related to this gene include thiolester hydrolase activity and palmitoyl hydrolase activity. An important paralog of this gene is PPT2-EGFL8.
UniProtKB/Swiss-Prot for PPT2 Gene
Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.