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Aliases for PPRC1 Gene

Aliases for PPRC1 Gene

  • Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related 1 2 3
  • PGC-1-Related Coactivator 3 4
  • PRC 3 4
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator-Related Protein 1 3
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator-Related 1 2
  • KIAA0595 4

External Ids for PPRC1 Gene

Previous GeneCards Identifiers for PPRC1 Gene

  • GC10P103558
  • GC10P103882
  • GC10P097524

Summaries for PPRC1 Gene

Entrez Gene Summary for PPRC1 Gene

  • The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for PPRC1 Gene

PPRC1 (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related 1) is a Protein Coding gene. Diseases associated with PPRC1 include oxyphilic adenoma. Among its related pathways are Energy Metabolism. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PPARGC1B.

UniProtKB/Swiss-Prot for PPRC1 Gene

  • Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.

Gene Wiki entry for PPRC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPRC1 Gene

Genomics for PPRC1 Gene

Regulatory Elements for PPRC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPRC1 Gene

102,132,994 bp from pter
102,150,333 bp from pter
17,340 bases
Plus strand

Genomic View for PPRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPRC1 Gene

Proteins for PPRC1 Gene

  • Protein details for PPRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5VV66
    • Q6P3U5
    • Q6P3W1
    • Q76N31
    • Q9BUJ3
    • Q9BZE5
    • Q9Y4E0

    Protein attributes for PPRC1 Gene

    1664 amino acids
    Molecular mass:
    177544 Da
    Quaternary structure:
    • Interacts with CREB1 and NRF1.
    • Sequence=AAH02561.2; Type=Frameshift; Positions=1643; Evidence={ECO:0000305}; Sequence=BAA25521.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPRC1 Gene


neXtProt entry for PPRC1 Gene

Proteomics data for PPRC1 Gene at MOPED

Post-translational modifications for PPRC1 Gene

  • Ubiquitination at Lys1645
  • Modification sites at PhosphoSitePlus

Other Protein References for PPRC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PPRC1 Gene

Domains for PPRC1 Gene

Gene Families for PPRC1 Gene

Protein Domains for PPRC1 Gene


Suggested Antigen Peptide Sequences for PPRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with PPRC1: view

Function for PPRC1 Gene

Molecular function for PPRC1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by serum (at protein level).

Gene Ontology (GO) - Molecular Function for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001104 RNA polymerase II transcription cofactor activity IBA --
GO:0003676 nucleic acid binding --
GO:0008134 transcription factor binding IBA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IBA --
genes like me logo Genes that share ontologies with PPRC1: view
genes like me logo Genes that share phenotypes with PPRC1: view

Animal Models for PPRC1 Gene

MGI Knock Outs for PPRC1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PPRC1 Gene

Localization for PPRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPRC1 Gene

Nucleus. Note=Colocalizes with NRF1. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PPRC1 Gene COMPARTMENTS Subcellular localization image for PPRC1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPRC1: view

Pathways for PPRC1 Gene

SuperPathways for PPRC1 Gene

Superpath Contained pathways
1 Energy Metabolism
genes like me logo Genes that share pathways with PPRC1: view

Pathways by source for PPRC1 Gene

1 BioSystems pathway for PPRC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
genes like me logo Genes that share ontologies with PPRC1: view

Transcripts for PPRC1 Gene

Unigene Clusters for PPRC1 Gene

Peroxisome proliferator-activated receptor gamma, coactivator-related 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPRC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPRC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - -
SP8: - - - - - -
SP9: - -
SP11: -

ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for PPRC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPRC1 Gene

mRNA expression in normal human tissues for PPRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PPRC1 Gene

This gene is overexpressed in Retina (66.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPRC1 Gene

SOURCE GeneReport for Unigene cluster for PPRC1 Gene Hs.533551

mRNA Expression by UniProt/SwissProt for PPRC1 Gene

Tissue specificity: Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.
genes like me logo Genes that share expressions with PPRC1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for PPRC1 Gene

Orthologs for PPRC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPRC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPRC1 35
  • 86.76 (n)
  • 83.48 (a)
PPRC1 36
  • 81 (a)
(Canis familiaris)
Mammalia PPRC1 35
  • 87.9 (n)
  • 85.28 (a)
PPRC1 36
  • 84 (a)
(Mus musculus)
Mammalia Pprc1 35
  • 81.32 (n)
  • 76.98 (a)
Pprc1 16
Pprc1 36
  • 73 (a)
(Pan troglodytes)
Mammalia PPRC1 35
  • 98.82 (n)
  • 98.38 (a)
PPRC1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pprc1 35
  • 81.99 (n)
  • 76.46 (a)
(Monodelphis domestica)
Mammalia PPRC1 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia PPRC1 36
  • 45 (a)
(Gallus gallus)
Aves PPRC1 36
  • 37 (a)
(Anolis carolinensis)
Reptilia PPRC1 36
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10020 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19433 35
(Danio rerio)
Actinopterygii sbcb478 35
pprc1 36
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spargel 36
  • 18 (a)
Species with no ortholog for PPRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPRC1 Gene

Gene Tree for PPRC1 (if available)
Gene Tree for PPRC1 (if available)

Paralogs for PPRC1 Gene

Paralogs for PPRC1 Gene

genes like me logo Genes that share paralogs with PPRC1: view

Variants for PPRC1 Gene

Sequence variations from dbSNP and Humsavar for PPRC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4917960 -- 102,134,948(+) CCCCC(C/G)AAAAC intron-variant
rs11357964 -- 102,145,014(+) CCCCC(-/C)GCCAG intron-variant
rs11819083 -- 102,132,208(+) TTCCT(C/G)TAAAC upstream-variant-2KB
rs12247573 -- 102,142,174(+) tggtg(C/T)aatct intron-variant
rs12780712 -- 102,136,409(+) AAGGT(A/C)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPRC1 Gene

Variant ID Type Subtype PubMed ID
nsv895968 CNV Loss 21882294

Relevant External Links for PPRC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPRC1 Gene

Disorders for PPRC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPRC1 Gene in MalaCards »

(1) Disease for PPRC1 Gene

(1) University of Copenhagen DISEASES for PPRC1 Gene

Relevant External Links for PPRC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PPRC1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for PPRC1 Gene

Publications for PPRC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. (PMID: 11340167) Andersson U. … Scarpulla R.C. (Mol. Cell. Biol. 2001) 2 3 4
  3. PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma. (PMID: 14550271) Savagner F. … Malthiery Y. (Biochem. Biophys. Res. Commun. 2003) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PMID: 19209188) Reiling E. … Dekker J.M. (Eur. J. Hum. Genet. 2009) 3 48

Products for PPRC1 Gene

Sources for PPRC1 Gene

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