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Aliases for PPRC1 Gene

Aliases for PPRC1 Gene

  • Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related 1 2 3 5
  • PGC-1-Related Coactivator 3 4
  • PRC 3 4
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator-Related Protein 1 3
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator-Related 1 2
  • KIAA0595 4

External Ids for PPRC1 Gene

Previous GeneCards Identifiers for PPRC1 Gene

  • GC10P103558
  • GC10P103882
  • GC10P097524

Summaries for PPRC1 Gene

Entrez Gene Summary for PPRC1 Gene

  • The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for PPRC1 Gene

PPRC1 (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related 1) is a Protein Coding gene. Diseases associated with PPRC1 include Epithelial Recurrent Erosion Dystrophy and Prosopagnosia. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial Gene Expression. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PPARGC1A.

UniProtKB/Swiss-Prot for PPRC1 Gene

  • Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.

Gene Wiki entry for PPRC1 Gene

Additional gene information for PPRC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPRC1 Gene

Genomics for PPRC1 Gene

Regulatory Elements for PPRC1 Gene

Enhancers for PPRC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H101828 1.7 FANTOM5 ENCODE dbSUPER 120.6 -302.0 -302011 4.4 HDGF PKNOX1 ARNT SIN3A ZNF2 ZBTB7B ZNF766 ZNF302 ZNF416 ZNF143 PPRC1 LDB1 GBF1 LZTS2 MRPL43 HPS6 NOLC1 MGEA5 SUFU ENSG00000272572
GH10H101692 1.5 FANTOM5 ENCODE 40.7 -438.6 -438647 3.1 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 SP3 SP5 PPRC1 GBF1 MRPL43 MGEA5 LDB1 ENSG00000272572 HPS6 TWNK SLF2 SUFU
GH10H101814 1.4 ENCODE dbSUPER 31.5 -315.9 -315886 5.9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 PPRC1 HPS6 LDB1 GBF1 MRPL43 TWNK SUFU NPM3 KCNIP2 MGEA5
GH10H101364 1.4 FANTOM5 ENCODE 29.3 -768.3 -768301 0.9 MLX ARNT ZFP64 ARID4B DMAP1 ETS1 SLC30A9 CBX5 PAF1 SP5 PPRC1 HPS6 LDB1 GBF1 MRPL43 BTRC FBXW4 RNU2-59P GC10M101365
GH10H101947 0.8 dbSUPER 51 -183.5 -183510 3.1 ZBTB21 ZNF493 ZFP64 ZNF140 ZNF266 ZNF697 ZNF664 ZNF433 ZNF639 ZNF202 PPRC1 MRPL43 GBF1 LDB1 TWNK LZTS2 ARL3 HPS6 KCNIP2-AS1 SFXN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPRC1 on UCSC Golden Path with GeneCards custom track

Promoters for PPRC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032693 606 2001 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2

Genomic Locations for PPRC1 Gene

Genomic Locations for PPRC1 Gene
chr10:102,132,994-102,150,333
(GRCh38/hg38)
Size:
17,340 bases
Orientation:
Plus strand
chr10:103,892,787-103,910,090
(GRCh37/hg19)

Genomic View for PPRC1 Gene

Genes around PPRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPRC1 Gene

Proteins for PPRC1 Gene

  • Protein details for PPRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV67-PPRC1_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    Protein Accession:
    Q5VV67
    Secondary Accessions:
    • Q5VV66
    • Q6P3U5
    • Q6P3W1
    • Q76N31
    • Q9BUJ3
    • Q9BZE5
    • Q9Y4E0

    Protein attributes for PPRC1 Gene

    Size:
    1664 amino acids
    Molecular mass:
    177544 Da
    Quaternary structure:
    • Interacts with CREB1 and NRF1.
    SequenceCaution:
    • Sequence=AAH02561.2; Type=Frameshift; Positions=1643; Evidence={ECO:0000305}; Sequence=BAA25521.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPRC1 Gene

Post-translational modifications for PPRC1 Gene

  • Ubiquitination at Lys1645
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPRC1 Gene

Domains & Families for PPRC1 Gene

Gene Families for PPRC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PPRC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPRC1: view

No data available for UniProtKB/Swiss-Prot for PPRC1 Gene

Function for PPRC1 Gene

Molecular function for PPRC1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by serum (at protein level).

Phenotypes From GWAS Catalog for PPRC1 Gene

Gene Ontology (GO) - Molecular Function for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003712 transcription cofactor activity IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0008134 transcription factor binding IBA,IEA --
genes like me logo Genes that share ontologies with PPRC1: view
genes like me logo Genes that share phenotypes with PPRC1: view

Animal Models for PPRC1 Gene

MGI Knock Outs for PPRC1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPRC1 Gene

Localization for PPRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPRC1 Gene

Nucleus. Note=Colocalizes with NRF1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPRC1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
endosome 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS,IDA --
genes like me logo Genes that share ontologies with PPRC1: view

Pathways & Interactions for PPRC1 Gene

genes like me logo Genes that share pathways with PPRC1: view

Pathways by source for PPRC1 Gene

Gene Ontology (GO) - Biological Process for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007005 mitochondrion organization TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with PPRC1: view

No data available for SIGNOR curated interactions for PPRC1 Gene

Drugs & Compounds for PPRC1 Gene

No Compound Related Data Available

Transcripts for PPRC1 Gene

Unigene Clusters for PPRC1 Gene

Peroxisome proliferator-activated receptor gamma, coactivator-related 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPRC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - -
SP8: - - - - - -
SP9: - -
SP10:
SP11: -
SP12:
SP13:

ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPRC1 Gene

GeneLoc Exon Structure for
PPRC1
ECgene alternative splicing isoforms for
PPRC1

Expression for PPRC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPRC1 Gene

This gene is overexpressed in Retina (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPRC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PPRC1 Gene:

PPRC1

SOURCE GeneReport for Unigene cluster for PPRC1 Gene:

Hs.533551

mRNA Expression by UniProt/SwissProt for PPRC1 Gene:

Q5VV67-PPRC1_HUMAN
Tissue specificity: Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.

Evidence on tissue expression from TISSUES for PPRC1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PPRC1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPRC1 Gene

Orthologs for PPRC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPRC1 33 34
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia PPRC1 33 34
  • 87.9 (n)
cow
(Bos Taurus)
Mammalia PPRC1 33 34
  • 86.76 (n)
rat
(Rattus norvegicus)
Mammalia Pprc1 33
  • 81.99 (n)
mouse
(Mus musculus)
Mammalia Pprc1 33 16 34
  • 81.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPRC1 34
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPRC1 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPRC1 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPRC1 34
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10020 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19433 33
zebrafish
(Danio rerio)
Actinopterygii pprc1 34
  • 30 (a)
OneToOne
sbcb478 33
fruit fly
(Drosophila melanogaster)
Insecta Spargel 34
  • 18 (a)
OneToMany
Species where no ortholog for PPRC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPRC1 Gene

ENSEMBL:
Gene Tree for PPRC1 (if available)
TreeFam:
Gene Tree for PPRC1 (if available)

Paralogs for PPRC1 Gene

Paralogs for PPRC1 Gene

genes like me logo Genes that share paralogs with PPRC1: view

Variants for PPRC1 Gene

Sequence variations from dbSNP and Humsavar for PPRC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs193920990 Uncertain significance 102,139,412(+) AGAGC(A/G)TCTCC nc-transcript-variant, reference, missense
rs1000093356 -- 102,143,986(+) CATAG(A/T)TCACC intron-variant
rs1000194324 -- 102,150,419(+) CTCCC(G/T)GGTCA downstream-variant-500B, upstream-variant-2KB
rs1000266996 -- 102,132,124(+) AAAGC(A/G)TCAAT upstream-variant-2KB
rs1000304010 -- 102,137,542(+) GCTGC(C/T)AGTAG intron-variant

Variation tolerance for PPRC1 Gene

Residual Variation Intolerance Score: 2.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPRC1 Gene

Human Gene Mutation Database (HGMD)
PPRC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPRC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPRC1 Gene

Disorders for PPRC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPRC1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
epithelial recurrent erosion dystrophy
  • recurrent erosion of cornea
prosopagnosia
- elite association - COSMIC cancer census association via MalaCards
Search PPRC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPRC1

Genetic Association Database (GAD)
PPRC1
Human Genome Epidemiology (HuGE) Navigator
PPRC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPRC1
genes like me logo Genes that share disorders with PPRC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPRC1 Gene

Publications for PPRC1 Gene

  1. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. (PMID: 11340167) Andersson U … Scarpulla RC (Molecular and cellular biology 2001) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  3. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PMID: 19209188) Reiling E … Dekker JM (European journal of human genetics : EJHG 2009) 3 45 60
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 45 60
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60

Products for PPRC1 Gene

Sources for PPRC1 Gene

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