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PPRC1 Gene

protein-coding   GIFtS: 59
GCID: GC10P103882

Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related...

(Previous names: peroxisome proliferative activated receptor, gamma, coactivator-related...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related
11 2
PRC2 3
PGC-1-Related Coactivator2 3
Peroxisome Proliferative Activated Receptor, Gamma, Coactivator-Related 11
Peroxisome Proliferator-Activated Receptor Gamma Coactivator-Related
Protein 12
KIAA05953

External Ids:    HGNC: 300251   Entrez Gene: 230822   Ensembl: ENSG000001488407   UniProtKB: Q5VV673   

Export aliases for PPRC1 gene to outside databases

Previous GC identifers: GC10P103558 GC10P097524


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPRC1 Gene:
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can
activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1).
This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma
coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2013)

GeneCards Summary for PPRC1 Gene:
PPRC1 (peroxisome proliferator-activated receptor gamma, coactivator-related 1) is a protein-coding gene. Diseases associated with PPRC1 include familial renal papillary carcinoma, and oxyphilic adenoma. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PPARGC1B.

UniProtKB/Swiss-Prot: PPRC1_HUMAN, Q5VV67
Function: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial
biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes

Gene Wiki entry for PPRC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPRC1 gene promoter:
         Pax-5   AP-2gamma   YY1   E47   CREB   USF-1   deltaCREB   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPRC1 promoter sequence
   Search Chromatin IP Primers for PPRC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

PPRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPRC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P103882:  view genomic region     (about GC identifiers)

Start:
103,892,787 bp from pter      End:
103,910,090 bp from pter
Size:
17,304 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPRC1_HUMAN, Q5VV67 (See protein sequence)
Recommended Name: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1  
Size: 1664 amino acids; 177544 Da
Subunit: Interacts with CREB1 and NRF1
Sequence caution: Sequence=AAH02561.2; Type=Frameshift; Positions=1643; Sequence=BAA25521.2; Type=Erroneous
initiation;
Secondary accessions: Q5VV66 Q6P3U5 Q6P3W1 Q76N31 Q9BUJ3 Q9BZE5 Q9Y4E0
Alternative splicing: 2 isoforms:  Q5VV67-1   Q5VV67-2   

Explore the universe of human proteins at neXtProt for PPRC1: NX_Q5VV67

Explore proteomics data for PPRC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1645
  • Modification sites at PhosphoSitePlus

  • See PPRC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001275656.1  NP_001275657.1  NP_055877.3  

    ENSEMBL proteins: 
     ENSP00000278070   ENSP00000359029   ENSP00000399743  
    Reactome Protein details: Q5VV67

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q5VV67

    ProtoNet protein and cluster: Q5VV67

    UniProtKB/Swiss-Prot: PPRC1_HUMAN, Q5VV67
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    PPRC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPRC1_HUMAN, Q5VV67
    Function: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial
    biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes
    Induction: Up-regulated by serum (at protein level)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    PPRC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPRC1:
     Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pprc1):
     embryogenesis  mortality/aging 

    PPRC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pprc1tm1Gning for PPRC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPRC1
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    miRNA
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    miRTarBase miRNAs that target PPRC1:
    hsa-mir-222-3p (MIRT046595), hsa-mir-7-5p (MIRT025837), hsa-mir-186-5p (MIRT045265), hsa-mir-124-3p (MIRT022950), hsa-mir-296-3p (MIRT038413), hsa-mir-183-5p (MIRT047060), hsa-mir-98-5p (MIRT027703), hsa-mir-425-5p (MIRT039315), hsa-let-7b-5p (MIRT051899)

    Block miRNA regulation of human, mouse, rat PPRC1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PPRC1:
    hsa-miR-153 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548c-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidPPRC1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPRC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPRC1_HUMAN, Q5VV67: Nucleus. Note=Colocalizes with NRF1 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    PPRC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPRC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Energy Metabolism
    Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PPRC1
        Energy Metabolism

    1 Reactome Pathway for PPRC1
        Transcriptional activation of mitochondrial biogenesis



    PPRC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PPRC1: 
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPRC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for PPRC1 (Q5VV673 ENSP000002780704) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRF1Q166563, ENSP000002231904I2D: score=3 STRING: ENSP00000223190
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    USF1P224153, ENSP000003569994I2D: score=1 STRING: ENSP00000356999
    USF2Q158533, ENSP000002223054I2D: score=1 STRING: ENSP00000222305
    TCEB1Q153693, ENSP000002848114I2D: score=1 STRING: ENSP00000284811
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    PPRC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPRC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPRC1 gene (3 alternative transcripts): 
    NM_001288727.1  NM_001288728.1  NM_015062.4  

    Unigene Cluster for PPRC1:

    Peroxisome proliferator-activated receptor gamma, coactivator-related 1
    Hs.533551  [show with all ESTs]
    Unigene Representative Sequence: AF325193
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278070(uc001kum.3 uc001kun.3 uc010qqj.2 uc009xxa.3)
    ENST00000370012 ENST00000489648 ENST00000462933 ENST00000495914 ENST00000413464

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate PPRC1:
    hsa-miR-153 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-548c-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidPPRC1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PPRC1 (NM_015062)
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      QuantiTect SYBR Green Assays in human, mouse, rat PPRC1
      QuantiFast Probe-based Assays in human, mouse, rat PPRC1

    Additional mRNA sequence: 

    AB011167.2 AF325193.1 AK025691.1 AK095248.1 AK299885.1 BC002561.2 BC063806.1 BC063829.1 

    10 DOTS entries:

    DT.315212  DT.100749394  DT.97815205  DT.91667927  DT.91994085  DT.95304080  DT.40114063  DT.91805121 
    DT.121291833  DT.97818776 

    Selected AceView cDNA sequences (see all 184):

    AW179106 AA461428 AW179115 BC063806 AA281980 BM129685 BU859134 AA749032 
    CN482168 AB011167 BU151362 BU520881 AW179120 BC002561 BG623754 BM457305 
    CB160801 AK025691 BM456531 BM129152 AK095248 BC063829 BU182725 BQ642812 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPRC1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^
    SP1:                    -     -     -                                                                             -                 -     -                     
    SP2:                    -     -     -           -     -                                                           -                 -     -                     
    SP3:                                                                                                              -           -     -     -     -     -         
    SP4:                                                                                                              -                 -     -     -     -         
    SP5:                                                                                                                                -     -     -     -         

    ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17
    SP1:  -                                 
    SP2:  -                                 
    SP3:  -                                 
    SP4:  -                                 
    SP5:  -                                 


    ECgene alternative splicing isoforms for PPRC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCGATCAG
    PPRC1 Expression
    About this image


    PPRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Outflow Tract
     
     Larynx (Respiratory System)
    PPRC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPRC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533551

    UniProtKB/Swiss-Prot: PPRC1_HUMAN, Q5VV67
    Tissue specificity: Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine,
    liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including PPRC1: 
              PPAR Targets in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPRC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPRC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pprc11 , 5 peroxisome proliferative activated receptor, gamma, more1, 5 81.32(n)1
    76.98(a)1
      19 (38.75 cM)5
    2261691  NM_001081214.11  NP_001074683.11 
     460448865 
    chicken
    (Gallus gallus)
    Aves PPRC16
    peroxisome proliferator-activated receptor gamma, ...
    37(a)
    1 ↔ 1
    6(22046342-22053845)
    lizard
    (Anolis carolinensis)
    Reptilia PPRC16
    peroxisome proliferator-activated receptor gamma, ...
    34(a)
    1 ↔ 1
    GL343239.1(1892286-1922652)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194332 Xenopus laevis transcribed sequence with weak similarity more 75.29(n)    BX855030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb4782 sbcb478 74.38(n)   321272  57050884 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spargel6
    Spargel
    18(a)
    1 → many
    3R(248205-255051)


    ENSEMBL Gene Tree for PPRC1 (if available)
    TreeFam Gene Tree for PPRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPRC1 gene
    PPARGC1B2  PPARGC1A2  

    PPRC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPRC1 (see all 489)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939209901,2
    Cuntested1103899169(+) AGAGCA/GTCTCC 2 I V mis10--------
    rs1451600341,2
    C--103890868(+) AATCAC/TTTGAA 1 -- us2k10--------
    rs1871215041,2
    --103890906(+) AAGATC/TGCGCC 1 -- us2k10--------
    rs1389838891,2
    C--103891080(+) GCCACA/GGCACT 1 -- us2k10--------
    rs1920816901,2
    C--103891214(+) CATGTA/GTGGGG 1 -- us2k10--------
    rs1834056841,2
    --103891256(+) ATTTTC/TTACTG 1 -- us2k10--------
    rs1117959501,2
    F--103891289(+) TAACTC/TGGCAC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1868166531,2
    --103891306(+) TTCATA/GGAAAC 1 -- us2k10--------
    rs742332491,2
    C,F--103891411(+) TAAACA/GACTTA 1 -- us2k12Minor allele frequency- G:0.14WA EA 238
    rs786676881,2
    C--103891506(+) ACCTCC/GTGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPRC1 (103892787 - 103910090 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPRC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895968CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPRC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PPRC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    9 diseases for PPRC1:    
    About MalaCards
    familial renal papillary carcinoma    oxyphilic adenoma    papillary carcinoma    leiomyomatosis
    adenoma    diabetes mellitus    alzheimer's disease    thyroiditis
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for PPRC1:
    Oxyphilic adenoma

    PPRC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPRC1
    Human Genome Epidemiology (HuGE) Navigator: PPRC1 (3 documents)

    Export disorders for PPRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPRC1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PPRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. (PubMed id 11340167)1, 2, 3 Andersson U. and Scarpulla R.C. (Mol. Cell. Biol. 2001)
    2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    3. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1, 4 Reiling E....Dekker J.M. (Eur. J. Hum. Genet. 2009)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma. (PubMed id 14550271)1, 2 Savagner F.... Malthiery Y. (Biochem. Biophys. Res. Commun. 2003)
    7. Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence. (PubMed id 23364789)1 Gleyzer N. and Scarpulla R.C. (J. Biol. Chem. 2013)
    8. PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF I_B activity. (PubMed id 23954632)1 Chengye Z....Shusheng L. (Biochem. Biophys. Res. Commun. 2013)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23082 HGNC: 30025 AceView: PPRC1 Ensembl:ENSG00000148840 euGenes: HUgn23082
    ECgene: PPRC1 H-InvDB: PPRC1

    (According to HUGE)
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    HUGE: KIAA0595

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPRC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPRC1 gene:
    Search GeneIP for patents involving PPRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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