Aliases for PPP6R2 Gene
External Ids for PPP6R2 Gene
Previous HGNC Symbols for PPP6R2 Gene
Previous GeneCards Identifiers for PPP6R2 Gene
The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]
GeneCards Summary for PPP6R2 Gene
PPP6R2 (Protein Phosphatase 6 Regulatory Subunit 2) is a Protein Coding gene. Diseases associated with PPP6R2 include Acute Cor Pulmonale and Acute Pulmonary Heart Disease. GO annotations related to this gene include binding. An important paralog of this gene is PPP6R3.
UniProtKB/Swiss-Prot for PPP6R2 Gene
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.