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Aliases for PPP6R2 Gene

Aliases for PPP6R2 Gene

  • Protein Phosphatase 6 Regulatory Subunit 2 2 3 5
  • KIAA0685 2 3 4
  • Protein Phosphatase 6, Regulatory Subunit 2 2 3
  • SAPS Domain Family, Member 2 2 3
  • SAPS2 3 4
  • PP6R2 3 4
  • SAPS Domain Family Member 2 4
  • SAP190 3

External Ids for PPP6R2 Gene

Previous HGNC Symbols for PPP6R2 Gene

  • KIAA0685
  • SAPS2

Previous GeneCards Identifiers for PPP6R2 Gene

  • GC22P050782
  • GC22P033700

Summaries for PPP6R2 Gene

Entrez Gene Summary for PPP6R2 Gene

  • Protein phosphatase regulatory subunits, such as SAPS2, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS2 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

GeneCards Summary for PPP6R2 Gene

PPP6R2 (Protein Phosphatase 6 Regulatory Subunit 2) is a Protein Coding gene. Diseases associated with PPP6R2 include Fusariosis. GO annotations related to this gene include binding. An important paralog of this gene is PPP6R3.

UniProtKB/Swiss-Prot for PPP6R2 Gene

  • Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP6R2 Gene

Genomics for PPP6R2 Gene

Regulatory Elements for PPP6R2 Gene

Enhancers for PPP6R2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP6R2 on UCSC Golden Path with GeneCards custom track

Promoters for PPP6R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP6R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP6R2 Gene

50,343,304 bp from pter
50,445,090 bp from pter
101,787 bases
Plus strand

Genomic View for PPP6R2 Gene

Genes around PPP6R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP6R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP6R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP6R2 Gene

Proteins for PPP6R2 Gene

  • Protein details for PPP6R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory subunit 2
    Protein Accession:
    Secondary Accessions:
    • A6PVG3
    • B7Z7T3
    • Q5U5P3
    • Q7Z2L2
    • Q7Z5G5
    • Q7Z731
    • Q9UGB9

    Protein attributes for PPP6R2 Gene

    966 amino acids
    Molecular mass:
    104942 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28.
    • Sequence=BAA31660.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP6R2 Gene

neXtProt entry for PPP6R2 Gene

Proteomics data for PPP6R2 Gene at MOPED

Post-translational modifications for PPP6R2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP6R2 Gene

Domains & Families for PPP6R2 Gene

Gene Families for PPP6R2 Gene

Protein Domains for PPP6R2 Gene

Suggested Antigen Peptide Sequences for PPP6R2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAPS family.
  • Belongs to the SAPS family.
genes like me logo Genes that share domains with PPP6R2: view

Function for PPP6R2 Gene

Molecular function for PPP6R2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.
genes like me logo Genes that share phenotypes with PPP6R2: view

Animal Model Products

CRISPR Products

miRNA for PPP6R2 Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP6R2 Gene

Localization for PPP6R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP6R2 Gene


Subcellular locations from

Jensen Localization Image for PPP6R2 Gene COMPARTMENTS Subcellular localization image for PPP6R2 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP6R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PPP6R2: view

Pathways & Interactions for PPP6R2 Gene

SuperPathways for PPP6R2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP6R2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PPP6R2 Gene

Drugs & Compounds for PPP6R2 Gene

No Compound Related Data Available

Transcripts for PPP6R2 Gene

Unigene Clusters for PPP6R2 Gene

Protein phosphatase 6, regulatory subunit 2:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP6R2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP6: - - -
SP7: - - - - - - -
SP10: - - -
SP11: - - -
SP12: - - - - -
SP13: -
SP14: -

ExUns: 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - -

Relevant External Links for PPP6R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP6R2 Gene

mRNA expression in normal human tissues for PPP6R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP6R2 Gene

This gene is overexpressed in Bone (13.3), Lung (12.0), and Colon (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP6R2 Gene

SOURCE GeneReport for Unigene cluster for PPP6R2 Gene Hs.449098

mRNA Expression by UniProt/SwissProt for PPP6R2 Gene

Tissue specificity: Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta.
genes like me logo Genes that share expression patterns with PPP6R2: view

Protein tissue co-expression partners for PPP6R2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for PPP6R2 Gene

Orthologs for PPP6R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP6R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP6R2 35
  • 82.23 (n)
  • 78.43 (a)
PPP6R2 36
  • 72 (a)
(Canis familiaris)
Mammalia PPP6R2 35
  • 83.22 (n)
  • 81.79 (a)
PPP6R2 36
  • 76 (a)
(Mus musculus)
Mammalia Ppp6r2 35
  • 83.59 (n)
  • 82.07 (a)
Ppp6r2 16
Ppp6r2 36
  • 81 (a)
(Pan troglodytes)
Mammalia PPP6R2 35
  • 99.04 (n)
  • 99.25 (a)
PPP6R2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ppp6r2 35
  • 83.24 (n)
  • 81.94 (a)
(Monodelphis domestica)
Mammalia PPP6R2 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PPP6R2 36
  • 68 (a)
(Gallus gallus)
Aves PPP6R2 35
  • 73.06 (n)
  • 71.98 (a)
PPP6R2 36
  • 66 (a)
(Anolis carolinensis)
Reptilia PPP6R2 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp6r2 35
  • 67.36 (n)
  • 68.9 (a)
(Danio rerio)
Actinopterygii ppp6r2a 35
  • 66.84 (n)
  • 64.61 (a)
ppp6r2a 36
  • 55 (a)
ppp6r2b 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10289 36
  • 13 (a)
(Caenorhabditis elegans)
Secernentea saps-1 36
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP155 36
  • 9 (a)
SAP185 36
  • 10 (a)
SAP190 36
  • 11 (a)
SAP4 36
  • 11 (a)
SAP190 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8358 36
  • 49 (a)
Species with no ortholog for PPP6R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP6R2 Gene

Gene Tree for PPP6R2 (if available)
Gene Tree for PPP6R2 (if available)

Paralogs for PPP6R2 Gene

Paralogs for PPP6R2 Gene

(2) SIMAP similar genes for PPP6R2 Gene using alignment to 2 proteins: Pseudogenes for PPP6R2 Gene

genes like me logo Genes that share paralogs with PPP6R2: view

Variants for PPP6R2 Gene

Sequence variations from dbSNP and Humsavar for PPP6R2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs11555194 - 50,438,233(+) GATGA(G/T)GAGGA reference, missense
rs13057311 - 50,439,767(+) GGTGA(A/G)GGACG reference, missense
rs13517 -- 50,443,361(+) TGCCC(C/T)TCCCT intron-variant
rs2076712 -- 50,432,191(+) GCCCA(G/T)TCCAG intron-variant
rs7287411 -- 50,386,121(+) cgccc(A/G)gacaa intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP6R2 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
nsv914517 CNV Loss 21882294
nsv914524 CNV Loss 21882294
nsv914525 CNV Loss 21882294
esv26897 CNV Loss 19812545
nsv829337 CNV Gain 20364138
nsv821599 CNV Deletion 20802225
nsv820090 CNV Loss 19587683
esv2660914 CNV Deletion 23128226
nsv3668 CNV Loss 18451855
nsv191443 CNV Loss 16902084
esv2665408 CNV Deletion 23128226
esv1021996 CNV Insertion 17803354
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
dgv5063n71 CNV Loss 21882294
nsv914541 CNV Loss 21882294
nsv512664 CNV Loss 21212237
esv23638 CNV Loss 19812545
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
nsv829338 CNV Gain 20364138

Variation tolerance for PPP6R2 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP6R2 Gene

Disorders for PPP6R2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP6R2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • fusarium infection
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP6R2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPP6R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP6R2 Gene

Publications for PPP6R2 Gene

  1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PMID: 16769727) Stefansson B. … Brautigan D.L. (J. Biol. Chem. 2006) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for PPP6R2 Gene

Sources for PPP6R2 Gene