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Aliases for PPP6R2 Gene

Aliases for PPP6R2 Gene

  • Protein Phosphatase 6 Regulatory Subunit 2 2 3 5
  • KIAA0685 2 3 4
  • SAPS Domain Family, Member 2 2 3
  • SAPS2 3 4
  • PP6R2 3 4
  • Serine/Threonine-Protein Phosphatase 6 Regulatory Subunit 2 3
  • Protein Phosphatase 6, Regulatory Subunit 2 2
  • SAPS Domain Family Member 2 4
  • SAP190 3

External Ids for PPP6R2 Gene

Previous HGNC Symbols for PPP6R2 Gene

  • KIAA0685
  • SAPS2

Previous GeneCards Identifiers for PPP6R2 Gene

  • GC22P050782
  • GC22P033700

Summaries for PPP6R2 Gene

Entrez Gene Summary for PPP6R2 Gene

  • The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]

GeneCards Summary for PPP6R2 Gene

PPP6R2 (Protein Phosphatase 6 Regulatory Subunit 2) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is PPP6R3.

UniProtKB/Swiss-Prot for PPP6R2 Gene

  • Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP6R2 Gene

Genomics for PPP6R2 Gene

Regulatory Elements for PPP6R2 Gene

Enhancers for PPP6R2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G050339 1 ENCODE 13.7 -3.1 -3081 2.1 HDGF ZNF493 ZNF2 KLF7 ZNF488 ZNF585B GLIS1 MYNN NBN ZNF300 ALG12 TUBGCP6 DENND6B ENSG00000272836 ZBED4 PPP6R2 ENSG00000273192 LOC105373095 TRABD SHANK3
GH22G050386 1.2 Ensembl ENCODE 11.2 +44.2 44206 2.3 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF121 SLC30A9 SP5 PPP6R2 HDAC10 GC22P050399 GC22P050372
GH22G050310 1 ENCODE dbSUPER 10.4 -32.8 -32768 0.2 CTCF KLF1 SAP130 TEAD1 ZMYM3 NR3C1 RAD21 TEAD3 TGIF2 GATAD1 DENND6B PPP6R2 ENSG00000227484 PLXNB2
GH22G049942 2 FANTOM5 Ensembl ENCODE dbSUPER 5.2 -394.1 -394063 13.5 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 TUBGCP6 ALG12 ENSG00000272836 DENND6B ZBED4 ENSG00000273192 LOC105373095 PIM3 PANX2 TRABD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP6R2 on UCSC Golden Path with GeneCards custom track

Promoters for PPP6R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147719 696 3200 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 SP3

Genomic Location for PPP6R2 Gene

50,343,304 bp from pter
50,445,090 bp from pter
101,787 bases
Plus strand

Genomic View for PPP6R2 Gene

Genes around PPP6R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP6R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP6R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP6R2 Gene

Proteins for PPP6R2 Gene

  • Protein details for PPP6R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory subunit 2
    Protein Accession:
    Secondary Accessions:
    • A6PVG3
    • B7Z7T3
    • Q5U5P3
    • Q7Z2L2
    • Q7Z5G5
    • Q7Z731
    • Q9UGB9

    Protein attributes for PPP6R2 Gene

    966 amino acids
    Molecular mass:
    104942 Da
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28.
    • Sequence=BAA31660.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP6R2 Gene

neXtProt entry for PPP6R2 Gene

Post-translational modifications for PPP6R2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP6R2 Gene

Domains & Families for PPP6R2 Gene

Gene Families for PPP6R2 Gene

Protein Domains for PPP6R2 Gene

Suggested Antigen Peptide Sequences for PPP6R2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAPS family.
  • Belongs to the SAPS family.
genes like me logo Genes that share domains with PPP6R2: view

Function for PPP6R2 Gene

Molecular function for PPP6R2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.

Gene Ontology (GO) - Molecular Function for PPP6R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with PPP6R2: view
genes like me logo Genes that share phenotypes with PPP6R2: view

Animal Models for PPP6R2 Gene

MGI Knock Outs for PPP6R2:

Animal Model Products

CRISPR Products

miRNA for PPP6R2 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP6R2 Gene

Localization for PPP6R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP6R2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP6R2 gene
Compartment Confidence
cytosol 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PPP6R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with PPP6R2: view

Pathways & Interactions for PPP6R2 Gene

SuperPathways for PPP6R2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP6R2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PPP6R2 Gene

Drugs & Compounds for PPP6R2 Gene

No Compound Related Data Available

Transcripts for PPP6R2 Gene

Unigene Clusters for PPP6R2 Gene

Protein phosphatase 6, regulatory subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP6R2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP6: - - -
SP7: - - - - - - -
SP10: - - -
SP11: - - -
SP12: - - - - -
SP13: -
SP14: -

ExUns: 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - -

Relevant External Links for PPP6R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP6R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP6R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP6R2 Gene

This gene is overexpressed in Bone (13.3), Lung (12.0), and Colon (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP6R2 Gene

Protein tissue co-expression partners for PPP6R2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP6R2 Gene:


SOURCE GeneReport for Unigene cluster for PPP6R2 Gene:


mRNA Expression by UniProt/SwissProt for PPP6R2 Gene:

Tissue specificity: Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta.

Evidence on tissue expression from TISSUES for PPP6R2 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Skin(4.3)
  • Muscle(4.2)
  • Lung(2.7)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with PPP6R2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP6R2 Gene

Orthologs for PPP6R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP6R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP6R2 34 35
  • 99.04 (n)
(Mus musculus)
Mammalia Ppp6r2 34 16 35
  • 83.59 (n)
(Rattus norvegicus)
Mammalia Ppp6r2 34
  • 83.24 (n)
(Canis familiaris)
Mammalia PPP6R2 34 35
  • 83.22 (n)
(Bos Taurus)
Mammalia PPP6R2 34 35
  • 82.23 (n)
(Monodelphis domestica)
Mammalia PPP6R2 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PPP6R2 35
  • 68 (a)
(Gallus gallus)
Aves PPP6R2 34 35
  • 73.06 (n)
(Anolis carolinensis)
Reptilia PPP6R2 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp6r2 34
  • 67.36 (n)
(Danio rerio)
Actinopterygii ppp6r2a 34 35
  • 66.84 (n)
ppp6r2b 35
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10289 35
  • 13 (a)
(Caenorhabditis elegans)
Secernentea saps-1 35
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP190 35 37
  • 11 (a)
SAP4 35
  • 11 (a)
SAP185 35
  • 10 (a)
SAP155 35
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8358 35
  • 49 (a)
Species where no ortholog for PPP6R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP6R2 Gene

Gene Tree for PPP6R2 (if available)
Gene Tree for PPP6R2 (if available)

Paralogs for PPP6R2 Gene

Paralogs for PPP6R2 Gene

(2) SIMAP similar genes for PPP6R2 Gene using alignment to 2 proteins: Pseudogenes for PPP6R2 Gene

genes like me logo Genes that share paralogs with PPP6R2: view

Variants for PPP6R2 Gene

Sequence variations from dbSNP and Humsavar for PPP6R2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs193920858 Uncertain significance 50,440,025(+) GCAGC(C/T)GGAGC reference, missense
rs1000033269 -- 50,429,458(+) GGAGC(A/G)AATCC intron-variant
rs1000062128 -- 50,424,417(+) AGGTC(C/T)GTCCG intron-variant
rs1000088850 -- 50,343,558(+) GAGTG(A/C)GGCCG intron-variant
rs1000110499 -- 50,392,534(+) GGCCT(C/T)ACCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP6R2 Gene

Variant ID Type Subtype PubMed ID
dgv8138n54 CNV gain+loss 21841781
dgv8139n54 CNV loss 21841781
esv1021996 CNV insertion 17803354
esv23638 CNV loss 19812545
esv2660914 CNV deletion 23128226
esv2665408 CNV deletion 23128226
esv26897 CNV loss 19812545
esv3558383 CNV deletion 23714750
esv3648087 CNV loss 21293372
esv3648088 CNV loss 21293372
nsv1072227 CNV deletion 25765185
nsv1073177 CNV deletion 25765185
nsv1073178 CNV deletion 25765185
nsv1118958 CNV deletion 24896259
nsv1126020 CNV deletion 24896259
nsv1136699 CNV deletion 24896259
nsv1143266 CNV deletion 24896259
nsv191443 CNV deletion 16902084
nsv3668 CNV deletion 18451855
nsv471224 CNV loss 18288195
nsv475818 CNV novel sequence insertion 20440878
nsv512664 CNV loss 21212237
nsv589215 CNV gain 21841781
nsv589217 CNV loss 21841781
nsv589220 CNV loss 21841781
nsv589221 CNV loss 21841781
nsv820090 CNV loss 19587683
nsv821599 CNV deletion 20802225
nsv829337 CNV gain 20364138
nsv829338 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv955200 CNV deletion 24416366
nsv955201 CNV deletion 24416366
nsv955492 CNV deletion 24416366

Variation tolerance for PPP6R2 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP6R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP6R2 Gene

Disorders for PPP6R2 Gene

Relevant External Links for PPP6R2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP6R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP6R2 Gene

Publications for PPP6R2 Gene

  1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PMID: 16769727) Stefansson B. … Brautigan D.L. (J. Biol. Chem. 2006) 2 3 4 64
  2. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4 64

Products for PPP6R2 Gene

Sources for PPP6R2 Gene

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