Aliases for PPP6R1 Gene
External Ids for PPP6R1 Gene
Previous HGNC Symbols for PPP6R1 Gene
Previous GeneCards Identifiers for PPP6R1 Gene
Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
GeneCards Summary for PPP6R1 Gene
PPP6R1 (Protein Phosphatase 6 Regulatory Subunit 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include binding and protein phosphatase binding. An important paralog of this gene is PPP6R3.
UniProtKB/Swiss-Prot for PPP6R1 Gene
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.