Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP6C Gene

Aliases for PPP6C Gene

  • Protein Phosphatase 6, Catalytic Subunit 2 3
  • EC 3.1.3.16 4 64
  • PP6C 3 4
  • Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit 3
  • Serine/Threonine Protein Phosphatase Catalytic Subunit 3
  • PPP6 4
  • PP6 3

External Ids for PPP6C Gene

Summaries for PPP6C Gene

Entrez Gene Summary for PPP6C Gene

  • This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP6C Gene

PPP6C (Protein Phosphatase 6, Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for PPP6C Gene

  • Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.

Gene Wiki entry for PPP6C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP6C Gene

Genomics for PPP6C Gene

Genomic Location for PPP6C Gene

Start:
125,146,573 bp from pter
End:
125,189,939 bp from pter
Size:
43,367 bases
Orientation:
Minus strand

Genomic View for PPP6C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP6C Gene

Regulatory Elements for PPP6C Gene

Proteins for PPP6C Gene

  • Protein details for PPP6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00743-PPP6_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 catalytic subunit
    Protein Accession:
    O00743
    Secondary Accessions:
    • B2R5V6
    • B7Z2W9
    • B7Z5K9
    • Q5U0A2
    • Q9UIC9

    Protein attributes for PPP6C Gene

    Size:
    305 amino acids
    Molecular mass:
    35144 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3.

    Alternative splice isoforms for PPP6C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP6C Gene

Proteomics data for PPP6C Gene at MOPED

Post-translational modifications for PPP6C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8, Lys132, Lys188, Lys219, and Lys231

Other Protein References for PPP6C Gene

Domains for PPP6C Gene

Gene Families for PPP6C Gene

HGNC:
  • PPP :Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

UniProtKB/Swiss-Prot:

PPP6_HUMAN
Family:
  • Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.:
    • O00743
genes like me logo Genes that share domains with PPP6C: view

Function for PPP6C Gene

Molecular function for PPP6C Gene

GENATLAS Biochemistry: serine/threonine protein phosphatase 6C,catalytic subunit,S cerevisiae Sit4P,cell-cycle regulatory gene,homolog
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.
UniProtKB/Swiss-Prot Induction: Regulated by IL2/interleukin-2 in peripheral blood T cells.

Enzyme Numbers (IUBMB) for PPP6C Gene

Gene Ontology (GO) - Molecular Function for PPP6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity IDA 16716191
GO:0005515 protein binding IPI 16085932
GO:0016787 hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP6C: view

Phenotypes for PPP6C Gene

GenomeRNAi human phenotypes for PPP6C:
genes like me logo Genes that share phenotypes with PPP6C: view

miRNA for PPP6C Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP6C Gene

Localization for PPP6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP6C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP6C Gene COMPARTMENTS Subcellular localization image for PPP6C gene
Compartment Confidence
cytosol 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16716191
genes like me logo Genes that share ontologies with PPP6C: view

Pathways for PPP6C Gene

SuperPathways for PPP6C Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 9013334
GO:0006470 protein dephosphorylation IDA 16716191
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with PPP6C: view

No data available for Pathways by source for PPP6C Gene

Compounds for PPP6C Gene

(5) HMDB Compounds for PPP6C Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Iron
  • Armco iron
7439-89-6
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with PPP6C: view

Transcripts for PPP6C Gene

Unigene Clusters for PPP6C Gene

Protein phosphatase 6, catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP6C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for PPP6C Gene

GeneLoc Exon Structure for
PPP6C
ECgene alternative splicing isoforms for
PPP6C

Expression for PPP6C Gene

mRNA expression in normal human tissues for PPP6C Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP6C Gene

SOURCE GeneReport for Unigene cluster for PPP6C Gene Hs.744091

mRNA Expression by UniProt/SwissProt for PPP6C Gene

O00743-PPP6_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
genes like me logo Genes that share expressions with PPP6C: view

Orthologs for PPP6C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP6C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP6C 36
  • 99.89 (n)
  • 100 (a)
PPP6C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP6C 36
  • 96.5 (n)
  • 100 (a)
PPP6C 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP6C 36
  • 96.5 (n)
  • 100 (a)
PPP6C 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp6c 36
  • 93.66 (n)
  • 99.67 (a)
Ppp6c 16
Ppp6c 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP6C 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP6C 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp6c 36
  • 93.33 (n)
  • 99.67 (a)
chicken
(Gallus gallus)
Aves PPP6C 36
  • 84.81 (n)
  • 99.67 (a)
PPP6C 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP6C 37
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6132 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp6c 36
  • 81.42 (n)
  • 99.67 (a)
Str.17180 36
zebrafish
(Danio rerio)
Actinopterygii ppp6c 36
  • 81.75 (n)
  • 99.67 (a)
ppp6c 37
  • 100 (a)
OneToOne
zgc56227 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003017 36
  • 67.66 (n)
  • 78.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta PpV 36
  • 67 (n)
  • 75.42 (a)
PpV 37
  • 75 (a)
OneToOne
PpV 38
  • 75 (a)
CG11597 38
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea pph-6 36
  • 60.63 (n)
  • 62.08 (a)
pph-6 37
  • 56 (a)
OneToOne
F42G8.8 38
  • 36 (a)
F49E11.7 38
  • 34 (a)
C27B7.6 38
  • 37 (a)
C34C12.3 38
  • 61 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER202C 36
  • 58.92 (n)
  • 65.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIT4 36
  • 60.56 (n)
  • 65.85 (a)
SIT4 37
  • 62 (a)
OneToOne
SIT4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03652g 36
  • 62.68 (n)
  • 65.49 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8766 36
thale cress
(Arabidopsis thaliana)
eudicotyledons FYPP3 36
  • 66.56 (n)
  • 69.54 (a)
rice
(Oryza sativa)
Liliopsida Os01g0691700 36
  • 66.45 (n)
  • 68.21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03436 36
  • 61.36 (n)
  • 69.16 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppe1 36
  • 65.78 (n)
  • 69.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 79 (a)
OneToOne
Species with no ortholog for PPP6C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP6C Gene

ENSEMBL:
Gene Tree for PPP6C (if available)
TreeFam:
Gene Tree for PPP6C (if available)

Paralogs for PPP6C Gene

Selected SIMAP similar genes for PPP6C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP6C Gene

genes like me logo Genes that share paralogs with PPP6C: view

No data available for Paralogs for PPP6C Gene

Variants for PPP6C Gene

Sequence variations from dbSNP and Humsavar for PPP6C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2535 -- 125,147,343(-) TTACT(C/G)CCTAT utr-variant-3-prime
rs6744 -- 125,146,790(-) GATTT(A/G)ACATC utr-variant-3-prime
rs165540 -- 125,184,016(+) cattt(G/T)gggag intron-variant
rs173391 -- 125,181,703(-) ccatc(A/G)atgat intron-variant
rs359574 -- 125,182,699(+) GCAGG(G/T)GACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP6C Gene

Variant ID Type Subtype PubMed ID
nsv893838 CNV Gain 21882294
esv2673169 CNV Deletion 23128226
nsv436612 CNV Deletion 17901297
esv23913 CNV Loss 19812545
esv2669933 CNV Deletion 23128226

Relevant External Links for PPP6C Gene

HapMap Linkage Disequilibrium report
PPP6C

Disorders for PPP6C Gene

Relevant External Links for PPP6C

Genetic Association Database (GAD)
PPP6C
Human Genome Epidemiology (HuGE) Navigator
PPP6C
genes like me logo Genes that share disorders with PPP6C: view

No data available for UniProtKB/Swiss-Prot for PPP6C Gene

Publications for PPP6C Gene

  1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PMID: 16769727) Stefansson B. … Brautigan D.L. (J. Biol. Chem. 2006) 3 4 23
  2. Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. (PMID: 17079228) Kajino T. … Ninomiya-Tsuji J. (J. Biol. Chem. 2006) 3 4
  3. Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. (PMID: 17568194) Stefansson B. … Brautigan D.L. (Cell Cycle 2007) 3 4
  4. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PMID: 18186651) Stefansson B. … Brautigan D.L. (Biochemistry 2008) 3 4
  5. The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation. (PMID: 9013334) Bastians H. … Ponstingl H. (J. Cell Sci. 1996) 3 4

Products for PPP6C Gene

Sources for PPP6C Gene

Back to Top

Content