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PPP6C Gene

protein-coding   GIFtS: 60
GCID: GC09M127908

Protein Phosphatase 6, Catalytic Subunit

  Search for PPP6C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 6, Catalytic Subunit1 2     Serine/Threonine Protein Phosphatase Catalytic Subunit2
PP6C2 3     Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit2
EC 3.1.3.163 8     PPP63
PP62     

External Ids:    HGNC: 93231   Entrez Gene: 55372   Ensembl: ENSG000001194147   OMIM: 6127255   UniProtKB: O007433   

Export aliases for PPP6C gene to outside databases

Previous GC identifers: GC09M119026 GC09M119557 GC09M121365 GC09M123287 GC09M124990 GC09M126948 GC09M097520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP6C Gene:
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell
cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is
located on chromosome X. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP6C Gene:
PPP6C (protein phosphatase 6, catalytic subunit) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743
Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating
cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase
progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the
IL1 signaling pathway by dephosphorylation of MAP3K7

Gene Wiki entry for PPP6C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PPP6C gene promoter:
         AREB6   AML1a   GATA-3   COMP1   Sox9   XBP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP6C promoter sequence
   Search Chromatin IP Primers for PPP6C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP6C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

PPP6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP6C gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M127908:  view genomic region     (about GC identifiers)

Start:
127,908,852 bp from pter      End:
127,952,218 bp from pter
Size:
43,367 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 6 catalytic subunit  
Size: 305 amino acids; 35144 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic
subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit
(ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3
Secondary accessions: B2R5V6 B7Z2W9 B7Z5K9 Q5U0A2 Q9UIC9
Alternative splicing: 3 isoforms:  O00743-1   O00743-2   O00743-3   

Explore the universe of human proteins at neXtProt for PPP6C: NX_O00743

Explore proteomics data for PPP6C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys132, Lys188, Lys219, Lys231
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP6C (O00743) (see all 11)
     HGQFYDL  GDFVDRG  YGFYDEC  CGDIHGQ 


    See PPP6C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116827.1  NP_001116841.1  NP_002712.1  

    ENSEMBL proteins: 
     ENSP00000362648   ENSP00000416287   ENSP00000392147   ENSP00000411744   ENSP00000362647  

    PPP6C Human Recombinant Protein Products:

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    Novus Biologicals PPP6C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPP6C

     
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    Search eBioscience for ELISAs for PPP6C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry O00743

    ProtoNet protein and cluster: O00743

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743
    Similarity: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily


    Find genes that share domains with PPP6C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPP6_HUMAN, O00743
    Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating
    cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase
    progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the
    IL1 signaling pathway by dephosphorylation of MAP3K7
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Induction: Regulated by IL2/interleukin-2 in peripheral blood T cells

         Genatlas biochemistry entry for PPP6C:
    serine/threonine protein phosphatase 6C,catalytic subunit,S cerevisiae Sit4P,cell-cycle regulatory gene,homolog

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IDA16716191
    GO:0005515protein binding IPI16085932
    GO:0016787hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PPP6C           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP6C:
     Decreased viability  Increased apoptosis 

         1 MGI phenotypic allele for Ppp6c (no phenotypes)

    Find genes that share phenotypes with PPP6C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP6C
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP6C

    miRNA
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    miRTarBase miRNAs that target PPP6C:
    hsa-mir-222-3p (MIRT046636), hsa-mir-92a-3p (MIRT049228), hsa-mir-16-5p (MIRT031938), hsa-mir-103a-3p (MIRT027236)

    Block miRNA regulation of human, mouse, rat PPP6C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP6C (see all 67):
    hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-4305 hsa-miR-93 hsa-miR-761 hsa-miR-490-3p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidPPP6C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP6C

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    GenScript: all cDNA clones in your preferred vector (see all 3): PPP6C (NM_002721)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP6C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPP6_HUMAN, O00743: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    cytoskeleton2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA16716191

    Find genes that share ontologies with PPP6C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP6C
    Interactions:

        Search GeneGlobe Interaction Network for PPP6C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP6C (O007431, 2, 3 ENSP000003921474) via UniProtKB, MINT, STRING, and/or I2D (see all 353)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS9013334
    GO:0006470protein dephosphorylation IDA16716191

    Find genes that share ontologies with PPP6C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP6C (PPP6)

    5 HMDB Compounds for PPP6C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP6C gene (3 alternative transcripts): 
    NM_001123355.1  NM_001123369.1  NM_002721.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373547 ENST00000456642 ENST00000451402(uc010mwv.3 uc004bpg.4)
    ENST00000415905(uc010mww.3 uc011lzr.2) ENST00000373546
    miRNA
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    Block miRNA regulation of human, mouse, rat PPP6C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP6C (see all 67):
    hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-4305 hsa-miR-93 hsa-miR-761 hsa-miR-490-3p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidPPP6C 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): PPP6C (NM_002721)
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP6C
      QuantiFast Probe-based Assays in human, mouse, rat PPP6C

    Selected AceView cDNA sequences (see all 354):

    BM549414 AI868028 AI420087 CB128620 BM794231 BX437501 AA251321 CB114962 
    AA814394 BQ013459 C04694 AA437027 BX331454 AA262101 BF196521 BM462910 
    AI418956 BQ005266 BQ014140 CA435980 CD676338 AI078288 CR604032 CA454964 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP6C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -                                                   
    SP2:              -           -                                       
    SP3:              -           -     -     -                           
    SP4:                                                                  


    ECgene alternative splicing isoforms for PPP6C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP6C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPP6C Expression
    About this image


    PPP6C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
    PPP6C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP6C Protein Expression

    UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743
    Tissue specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart,
    kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP6C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP6C gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp6c1 , 5 protein phosphatase 6, catalytic subunit1, 5 93.66(n)1
    99.67(a)1
      2 (24.44 cM)5
    678571  NM_024209.21  NP_077171.11 
     391943545 
    chicken
    (Gallus gallus)
    Aves PPP6C1 protein phosphatase 6, catalytic subunit 84.81(n)
    99.67(a)
      772354  NM_001079765.1  NP_001073233.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP6C6
    protein phosphatase 6, catalytic subunit
    100(a)
    1 ↔ 1
    AAWZ02040697(150-4760)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61322 Xenopus laevis transcribed sequence with moderate similarity more 80.39(n)    BU901768.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562272 similar to protein phosphatase 6, catalytic subunit 81.93(n)   393980  BC047847.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PpV1 , 3 protein amino acid dephosphorylation
    protein serine/threonine more3
    Protein phosphatase V1
    75(a)
    (best of 2)3
    67(n)1
    75.42(a)1
      5F43
    315821  NM_001272345.11  NP_001259274.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C34C12.33
    pph-61
    PROTEIN PHOSPHATASE3
    pph-61
    61(a)
    (best of 4)3
    60.63(n)1
    62.08(a)1
      III(3533518-3538792)3
    1831991  NM_065313.51  NP_497714.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIT4(YDL047W)4
    SIT41
    Type 2A-related serine-threonine phosphatase that functions more4
    SIT41
    60.56(n)1
    65.85(a)1
      4(369771-370706)4
    8515131, 4  NP_010236.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FYPP31 FYPP3 66.56(n)
    69.54(a)
      821536  NM_112888.3  NP_188632.1 
    rice
    (Oryza sativa)
    Liliopsida AK068018.12   -- 74.32(n)    AK068018.1 


    ENSEMBL Gene Tree for PPP6C (if available)
    TreeFam Gene Tree for PPP6C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP6C gene
    12 SIMAP similar genes for PPP6C using alignment to 3 protein entries:     PPP6_HUMAN (see all proteins):
    PPP2CB    PPP2CA    PPP4C    CDKL3    PPP1CC    PPP1CA
    PPP1CB    PPP3CB    PPP5C    PPP3CA    PPP3CC    PPEF1

    Find genes that share paralogs with PPP6C           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PPP6C
    PGOHUM00000241945


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP6C (see all 1017)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122370751,2
    C,F--127908417(+) ACTTAT/CGTAGT 3 -- ds50012Minor allele frequency- C:0.09WA EA 238
    rs1868008811,2
    --127908512(+) ACTCTC/TATGAG 3 -- ds50010--------
    rs765070741,2
    C--127908715(+) TCTCAT/CGAAGC 3 -- ds50012Minor allele frequency- C:0.21CSA WA 120
    rs59006431,2
    C--127908779(+) TTGGA-/ACACTTA 3 -- ds50011Minor allele frequency- AC:0.00CSA 2
    rs573639471,2
    C--127908806(+) AAAAA-/AGGTTT 3 -- ds50010--------
    rs761611311,2
    C,F--127908952(+) TGTAAT/CCTTTT 3 -- ut311Minor allele frequency- C:0.18EA 120
    rs772792711,2
    C--127908988(+) GCACCC/TTTCAT 3 -- ut310--------
    rs67441,2
    C,F,O,A,H--127909069(-) GATTTA/GACATC 3 -- ut31101Minor allele frequency- G:0.48MN NS EA NA PA EU CA WA CSA 5282
    rs749440001,2
    C,F--127909089(+) CCAGAT/CACACA 3 -- ut311Minor allele frequency- C:0.17EA 120
    rs1902153961,2
    --127909117(+) GGAAAA/GTGATT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP6C (127908852 - 127952218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PPP6C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673169CNV Deletion23128226
    esv2669933CNV Deletion23128226
    nsv436612CNV Deletion17901297
    esv23913CNV Loss19812545
    nsv893838CNV Gain21882294

    1 Site Specific Mutation Identification with PCR Assay for PPP6C:
    Cosmic IdAA Change
    221754p.R264C
    SeqTarget long-range PCR primers for resequencing PPP6C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612725    OMIM disorders: --


    Find genes that share disorders with PPP6C           About GenesLikeMe

    Genetic Association Database (GAD): PPP6C
    Human Genome Epidemiology (HuGE) Navigator: PPP6C (2 documents)

    Export disorders for PPP6C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP6C gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with PPP6C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PubMed id 16769727)1, 2, 9 Stefansson B. and Brautigan D.L. (J. Biol. Chem. 2006)
    2. Lack of replication of celiac disease risk variants reported in a Spanish population using an independent Spanish sample. (PubMed id 19626039)1, 4 Dema B....NA_A+ez C. (Genes Immun. 2009)
    3. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PubMed id 18186651)1, 2 Stefansson B.... Brautigan D.L. (Biochemistry 2008)
    4. Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. (PubMed id 17568194)1, 2 Stefansson B. and Brautigan D.L. (Cell Cycle 2007)
    5. Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. (PubMed id 17079228)1, 2 Kajino T.... Ninomiya-Tsuji J. (J. Biol. Chem. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Alpha 4 associates with protein phosphatases 2A, 4, and 6. (PubMed id 9647778)1, 2 Chen J.... Schreiber S.L. (Biochem. Biophys. Res. Commun. 1998)
    8. Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3. (PubMed id 9143513)1, 3 Bastians H....Joos S. (Genomics 1997)
    9. The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation. (PubMed id 9013334)1, 2 Bastians H. and Ponstingl H. (J. Cell Sci. 1996)
    10. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5537 HGNC: 9323 AceView: PPP6C Ensembl:ENSG00000119414 euGenes: HUgn5537
    ECgene: PPP6C H-InvDB: PPP6C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP6C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP6C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP6C gene:
    Search GeneIP for patents involving PPP6C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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