Aliases for PPP6C Gene
External Ids for PPP6C Gene
Previous GeneCards Identifiers for PPP6C Gene
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP6C Gene
PPP6C (Protein Phosphatase 6 Catalytic Subunit) is a Protein Coding gene. Diseases associated with PPP6C include Pineal Parenchymal Tumor Of Intermediate Differentiation and Usher Syndrome, Type 1C. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification. GO annotations related to this gene include hydrolase activity and protein serine/threonine phosphatase activity.
UniProtKB/Swiss-Prot for PPP6C Gene
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.