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Aliases for PPP6C Gene

Aliases for PPP6C Gene

  • Protein Phosphatase 6 Catalytic Subunit 2 3
  • Protein Phosphatase 6, Catalytic Subunit 2 3 5
  • EC 3.1.3.16 4 63
  • PP6C 3 4
  • Serine/Threonine Protein Phosphatase Catalytic Subunit 3
  • PPP6 4
  • PP6 3

External Ids for PPP6C Gene

Previous GeneCards Identifiers for PPP6C Gene

  • GC09M119026
  • GC09M119557
  • GC09M121365
  • GC09M123287
  • GC09M124990
  • GC09M126948
  • GC09M127908
  • GC09M097520

Summaries for PPP6C Gene

Entrez Gene Summary for PPP6C Gene

  • This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP6C Gene

PPP6C (Protein Phosphatase 6 Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include hydrolase activity and protein serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for PPP6C Gene

  • Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.

Gene Wiki entry for PPP6C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP6C Gene

Genomics for PPP6C Gene

Regulatory Elements for PPP6C Gene

Promoters for PPP6C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP6C on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP6C Gene

Chromosome:
9
Start:
125,146,573 bp from pter
End:
125,189,939 bp from pter
Size:
43,367 bases
Orientation:
Minus strand

Genomic View for PPP6C Gene

Genes around PPP6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP6C Gene

Proteins for PPP6C Gene

  • Protein details for PPP6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00743-PPP6_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 6 catalytic subunit
    Protein Accession:
    O00743
    Secondary Accessions:
    • B2R5V6
    • B7Z2W9
    • B7Z5K9
    • Q5U0A2
    • Q9UIC9

    Protein attributes for PPP6C Gene

    Size:
    305 amino acids
    Molecular mass:
    35144 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3.

    Alternative splice isoforms for PPP6C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP6C Gene

Proteomics data for PPP6C Gene at MOPED

Post-translational modifications for PPP6C Gene

  • Ubiquitination at Lys 8, Lys 132, Lys 188, Lys 219, and Lys 231
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP6C Gene

Antibody Products

Domains & Families for PPP6C Gene

Gene Families for PPP6C Gene

Graphical View of Domain Structure for InterPro Entry

O00743

UniProtKB/Swiss-Prot:

PPP6_HUMAN :
  • Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
genes like me logo Genes that share domains with PPP6C: view

Function for PPP6C Gene

Molecular function for PPP6C Gene

GENATLAS Biochemistry:
serine/threonine protein phosphatase 6C,catalytic subunit,S cerevisiae Sit4P,cell-cycle regulatory gene,homolog
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.
UniProtKB/Swiss-Prot Induction:
Regulated by IL2/interleukin-2 in peripheral blood T cells.

Enzyme Numbers (IUBMB) for PPP6C Gene

Gene Ontology (GO) - Molecular Function for PPP6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9647778
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP6C: view
genes like me logo Genes that share phenotypes with PPP6C: view

Animal Models for PPP6C Gene

MGI Knock Outs for PPP6C:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP6C

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP6C Gene

Localization for PPP6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP6C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP6C Gene COMPARTMENTS Subcellular localization image for PPP6C gene
Compartment Confidence
cytosol 5
golgi apparatus 4
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for PPP6C Gene

Pathways & Interactions for PPP6C Gene

genes like me logo Genes that share pathways with PPP6C: view

SIGNOR curated interactions for PPP6C Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PPP6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with PPP6C: view

Drugs & Compounds for PPP6C Gene

(2) Drugs for PPP6C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
calcium Nutra 0

(4) Additional Compounds for PPP6C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PPP6C: view

Transcripts for PPP6C Gene

Unigene Clusters for PPP6C Gene

Protein phosphatase 6, catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP6C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for PPP6C Gene

GeneLoc Exon Structure for
PPP6C
ECgene alternative splicing isoforms for
PPP6C

Expression for PPP6C Gene

mRNA expression in normal human tissues for PPP6C Gene

Protein differential expression in normal tissues from HIPED for PPP6C Gene

This gene is overexpressed in Bone (16.2) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP6C Gene



SOURCE GeneReport for Unigene cluster for PPP6C Gene Hs.744091

mRNA Expression by UniProt/SwissProt for PPP6C Gene

O00743-PPP6_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
genes like me logo Genes that share expression patterns with PPP6C: view

Protein tissue co-expression partners for PPP6C Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP6C Gene

Orthologs for PPP6C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP6C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP6C 35
  • 96.5 (n)
  • 100 (a)
PPP6C 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP6C 35
  • 96.5 (n)
  • 100 (a)
PPP6C 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp6c 35
  • 93.66 (n)
  • 99.67 (a)
Ppp6c 16
Ppp6c 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP6C 35
  • 99.89 (n)
  • 100 (a)
PPP6C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp6c 35
  • 93.33 (n)
  • 99.67 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP6C 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP6C 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP6C 35
  • 84.81 (n)
  • 99.67 (a)
PPP6C 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP6C 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp6c 35
  • 81.42 (n)
  • 99.67 (a)
Str.17180 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6132 35
zebrafish
(Danio rerio)
Actinopterygii ppp6c 35
  • 81.75 (n)
  • 99.67 (a)
zgc56227 35
ppp6c 36
  • 100 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11597 37
  • 51 (a)
PpV 37
  • 75 (a)
PpV 35
  • 67 (n)
  • 75.42 (a)
PpV 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003017 35
  • 67.66 (n)
  • 78.41 (a)
worm
(Caenorhabditis elegans)
Secernentea C27B7.6 37
  • 37 (a)
C34C12.3 37
  • 61 (a)
F42G8.8 37
  • 36 (a)
F49E11.7 37
  • 34 (a)
pph-6 35
  • 60.63 (n)
  • 62.08 (a)
pph-6 36
  • 56 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER202C 35
  • 58.92 (n)
  • 65.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03652g 35
  • 62.68 (n)
  • 65.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIT4 35
  • 60.56 (n)
  • 65.85 (a)
SIT4 36
  • 62 (a)
OneToOne
SIT4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FYPP3 35
  • 66.56 (n)
  • 69.54 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8766 35
rice
(Oryza sativa)
Liliopsida Os01g0691700 35
  • 66.45 (n)
  • 68.21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03436 35
  • 61.36 (n)
  • 69.16 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppe1 35
  • 65.78 (n)
  • 69.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for PPP6C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP6C Gene

ENSEMBL:
Gene Tree for PPP6C (if available)
TreeFam:
Gene Tree for PPP6C (if available)

Paralogs for PPP6C Gene

(12) SIMAP similar genes for PPP6C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP6C Gene

genes like me logo Genes that share paralogs with PPP6C: view

No data available for Paralogs for PPP6C Gene

Variants for PPP6C Gene

Sequence variations from dbSNP and Humsavar for PPP6C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2535 -- 125,147,343(-) TTACT(C/G)CCTAT utr-variant-3-prime
rs6744 -- 125,146,790(-) GATTT(A/G)ACATC utr-variant-3-prime
rs165540 -- 125,184,016(+) cattt(G/T)gggag intron-variant
rs359574 -- 125,182,699(+) GCAGG(G/T)GACTG intron-variant
rs359575 -- 125,182,823(+) acact(A/G)ccaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP6C Gene

Variant ID Type Subtype PubMed ID
nsv893838 CNV Gain 21882294
esv2673169 CNV Deletion 23128226
nsv436612 CNV Deletion 17901297
esv23913 CNV Loss 19812545
esv2669933 CNV Deletion 23128226

Variation tolerance for PPP6C Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP6C Gene

HapMap Linkage Disequilibrium report
PPP6C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP6C Gene

Disorders for PPP6C Gene

Relevant External Links for PPP6C

Genetic Association Database (GAD)
PPP6C
Human Genome Epidemiology (HuGE) Navigator
PPP6C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP6C

No disorders were found for PPP6C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP6C Gene

Publications for PPP6C Gene

  1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PMID: 16769727) Stefansson B. … Brautigan D.L. (J. Biol. Chem. 2006) 3 4 23 67
  2. Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3. (PMID: 9143513) Bastians H. … Joos S. (Genomics 1997) 2 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PPP6C Gene

Sources for PPP6C Gene

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