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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP6C Gene

protein-coding   GIFtS: 61
GCID: GC09M127908

protein phosphatase 6, catalytic subunit

 Explore 3 diseases affiliated with
PPP6C via our new
 Human Malady Compendium 
Biological research products
for PPP6C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Protein Phosphatase 6, Catalytic Subunit1 2     Serine/Threonine Protein Phosphatase Catalytic Subunit2
PP61 2     Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit2
PP6C2 3     PPP63
EC 3.1.3.163 8     

External Ids:    HGNC: 93231   Entrez Gene: 55372   Ensembl: ENSG000001194147   OMIM: 6127255   UniProtKB: O007433   

Export aliases for PPP6C gene to outside databases

Previous GC identifers: GC09M119026 GC09M119557 GC09M121365 GC09M123287 GC09M124990 GC09M126948 GC09M097520


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP6C:
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell
cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located
on chromosome X. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743
Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell
cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in
cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling
pathway by dephosphorylation of MAP3K7

Gene Wiki entry for PPP6C


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP6C gene promoter:
         AREB6   AML1a   GATA-3   COMP1   Sox9   XBP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP6C promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP6C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP6C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

PPP6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP6C gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M127908:  view genomic region     (about GC identifiers)

Start:
127,908,852 bp from pter      End:
127,952,218 bp from pter
Size:
43,367 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 6 catalytic subunit  
Size: 305 amino acids; 35144 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic
subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3
Subcellular location: Cytoplasm
Secondary accessions: B2R5V6 B7Z2W9 B7Z5K9 Q5U0A2 Q9UIC9
Alternative splicing: 3 isoforms:  O00743-1   O00743-2   O00743-3   

Explore the universe of human proteins at neXtProt for PPP6C: NX_O00743

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00743

  • 4/11 DME Specific Peptides for PPP6C (O00743) (see all 11)
     HGQFYDL  GDFVDRG  YGFYDEC  CGDIHGQ 

    PPP6C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116827.1  NP_001116841.1  NP_002712.1  

    ENSEMBL proteins: 
     ENSP00000362648   ENSP00000416287   ENSP00000392147   ENSP00000411744   ENSP00000362647  

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    Novus Biologicals PPP6C Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PPP6C

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA16716191


    PPP6C for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PPP6C for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004843 Metallo_PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry O00743

    ProtoNet protein and cluster: O00743

    1 Blocks protein family: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743
    Similarity: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743
    Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell
    cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in
    cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling
    pathway by dephosphorylation of MAP3K7
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Induction: Regulated by IL2/interleukin-2 in peripheral blood T cells

         Genatlas biochemistry entry for PPP6C:
    serine/threonine protein phosphatase 6C,catalytic subunit,S cerevisiae Sit4P,cell-cycle regulatory gene,homolog

    Enzyme Number (IUBMB): EC 3.1.3.161 2

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    hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-4305 hsa-miR-93 hsa-miR-761 hsa-miR-490-3p hsa-miR-520b
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IDA16716191
    GO:0005515protein binding IPI18186651
    GO:0046872metal ion binding IEA--


    PPP6C for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PPP6C:
     Decreased viability  Increased apoptosis 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP6C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for PPP6C (O007431, 2, 3 ENSP000003921474) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS9013334
    GO:0006470protein dephosphorylation IDA16716191


    PPP6C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP6C

    5 HMDB Compounds for PPP6C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about PPP6C / PPP6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP6C gene (3 alternative transcripts): 
    NM_001123355.1  NM_001123369.1  NM_002721.4  

    Unigene Cluster for PPP6C:

    Protein phosphatase 6, catalytic subunit
    Hs.744091  [show with all ESTs]
    Unigene Representative Sequence: NM_001123355
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373547 ENST00000456642 ENST00000451402(uc010mwv.3 uc004bpg.4)
    ENST00000415905(uc010mww.3 uc011lzr.2) ENST00000373546

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    hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-4305 hsa-miR-93 hsa-miR-761 hsa-miR-490-3p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidPPP6C 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF035158.2 AK295190.1 AK295752.1 AK299087.1 AK312332.1 AK316527.1 BC006990.1 BT019708.1 
    X92972.2 

    16 DOTS entries:

    DT.91757153  DT.116298  DT.91757147  DT.97813299  DT.101959415  DT.99997013  DT.121185653  DT.99937728 
    DT.91837812  DT.100025992  DT.100817653  DT.91757149  DT.100025993  DT.87045975  DT.91932101  DT.95206120 

    24/354 AceView cDNA sequences (see all 354):

    BM462910 AA437027 CB128620 CB128697 CR621615 BE467157 AA287679 AI341874 
    BE501963 AA814394 BP338815 BX331454 CR604032 BM794231 CD676338 CB114962 
    AI868028 C04694 AI418956 AI078288 BM999552 AA449518 AA435871 BQ013459 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP6C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -                                                   
    SP2:              -           -                                       
    SP3:              -           -     -     -                           
    SP4:                                                                  


    ECgene alternative splicing isoforms for PPP6C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP6C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PPP6C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP6C

    SOURCE GeneReport for Unigene cluster: Hs.744091

    UniProtKB/Swiss-Prot: PPP6_HUMAN, O00743
    Tissue specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart,
    kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP6C gene from 9/39 species (see all 39)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PPP6C1 protein phosphatase 6, catalytic subunit 84.81(n)
    99.67(a)
      772354  NM_001079765.1  NP_001073233.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP6C6
    --
    100(a)
    1 ↔ 1
    AAWZ02040697(1035-4760)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61322 Xenopus laevis transcribed sequence with moderate similarity more 80.39(n)    BU901768.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562272 similar to protein phosphatase 6, catalytic subunit 81.93(n)   393980  BC047847.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PpV1 , 3 protein amino acid dephosphorylation protein
    serine/threonine more3
    Protein phosphatase V1
    75(a)
    (best of 2)3
    67(n)1
    75.42(a)1
      5F43
    315821  NM_078506.21  NP_511061.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C34C12.33
    pph-61
    PROTEIN PHOSPHATASE3
    Protein PPH-61
    61(a)
    (best of 4)3
    60.69(n)1
    61.46(a)1
      III(3533518-3538792)3
    1831991  NM_065313.41  NP_497714.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIT4(YDL047W)4
    SIT41
    Type 2A-related serine-threonine phosphatase that functions more4
    Sit4p1
    60.33(n)1
    65.85(a)1
      4(369771-370706)4
    8515131, 4  NP_010236.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FYPP31 phytochrome-associated serine/threonine protein phosphatase more 66.56(n)
    69.54(a)
      821536  NM_112888.3  NP_188632.1 
    rice
    (Oryza sativa)
    Liliopsida AK068018.12   -- 74.32(n)    AK068018.1 


    ENSEMBL Gene Tree for PPP6C (if available)
    TreeFam Gene Tree for PPP6C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP6C gene
    11 SIMAP similar genes for PPP6C using alignment to 3 protein entries:     PPP6_HUMAN (see all proteins):
    PPP2CB    PPP2CA    PPP4C    PPP1CC    PPP1CA    PPP1CB
    PPP3CB    PPP5C    PPP3CA    PPP3CC    PPEF1

    PPP6C for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPP6C
    PGOHUM00000241945


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/818 NCBI SNPs in PPP6C are shown (see all 818    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122370751,2
    F,--127908417(+) ACTTAT/CGTAGT 3 -- ds50012Minor allele frequency- C:0.09WA EA 238
    rs1868008811,2
    --127908512(+) ACTCTC/TATGAG 3 -- ds50010--------
    rs765070741,2
    C,--127908715(+) TCTCAT/CGAAGC 3 -- ds50012Minor allele frequency- C:0.21CSA WA 120
    rs59006431,2
    C,--127908779(+) TTGGA-/ACACTTA 3 -- ds50011Minor allele frequency- AC:0.00CSA 2
    rs573639471,2
    C--127908807(+) AAAAA-/AGGTTT 3 -- ds50010--------
    rs761611311,2
    C,F,--127908952(+) TGTAAT/CCTTTT 3 -- ut311Minor allele frequency- C:0.18EA 120
    rs772792711,2
    --127908988(+) GCACCC/TTTCAT 3 -- ut310--------
    rs67441,2
    C,F,O,A,H,--127909069(-) GATTTA/GACATC 3 -- ut31101Minor allele frequency- G:0.48MN NS EA NA PA EU CA WA CSA 5282
    rs749440001,2
    C,F,--127909089(+) CCAGAT/CACACA 3 -- ut311Minor allele frequency- C:0.17EA 120
    rs1902153961,2
    --127909117(+) GGAAAA/GTGATT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP6C (127908852 - 127952218 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PPP6C
         2 CNVs: 22634 65514

    1 SABiosciences Cancer Mutation PCR Assay for PPP6C:
    Cosmic IdAA Change
    221754p.R264C
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP6C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PPP6C for disorders           About GeneDecksing

    OMIM gene information: 612725    OMIM disorders: --

    3 diseases for PPP6C:    About MalaCards
    pineal parenchymal tumor of intermediate differentiation    celiac disease    malaria

    Human Genome Epidemiology (HuGE) Navigator: PPP6C (2 documents)

    Export disorders for PPP6C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP6C gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with PPP6C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PubMed id 16769727)1, 2, 9 Stefansson B. and Brautigan D.L. (2006)
    2. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PubMed id 18186651)1, 2 Stefansson B.... Brautigan D.L. (2008)
    3. Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. (PubMed id 17568194)1, 2 Stefansson B. and Brautigan D.L. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Alpha 4 associates with protein phosphatases 2A, 4, and 6. (PubMed id 9647778)1, 2 Chen J.... Schreiber S.L. (1998)
    6. Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3. (PubMed id 9143513)1, 3 Bastians H....Joos S. (1997)
    7. The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation. (PubMed id 9013334)1, 2 Bastians H. and Ponstingl H. (1996)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5537 HGNC: 9323 AceView: PPP6C Ensembl:ENSG00000119414 euGenes: HUgn5537
    ECgene: PPP6C H-InvDB: PPP6C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP6C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP6C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP6C gene:
    Search GeneIP for patents involving PPP6C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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