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Aliases for PPP5D1 Gene

Aliases for PPP5D1 Gene

  • PPP5 Tetratricopeptide Repeat Domain Containing 1 2 3 5
  • PPP5 TPR Repeat Domain-Containing Protein 1 4

External Ids for PPP5D1 Gene

Previous GeneCards Identifiers for PPP5D1 Gene

  • GC19M046985

Summaries for PPP5D1 Gene

GeneCards Summary for PPP5D1 Gene

PPP5D1 (PPP5 Tetratricopeptide Repeat Domain Containing 1) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP5D1 Gene

Genomics for PPP5D1 Gene

Regulatory Elements for PPP5D1 Gene

Enhancers for PPP5D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G047225 1.5 ENCODE dbSUPER 33.6 -628.2 -628182 8.2 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 PPP5D1 PRKD2 SLC1A5 ENSG00000268746 SNORD23
GH19G047239 2 FANTOM5 Ensembl ENCODE dbSUPER 24.8 -639.4 -639360 3.1 CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZC3H4 BICRA NOP53-AS1 ENSG00000268810 PPP5D1 C19orf68 CCDC9 SLC8A2 SLC1A5 ENSG00000268746
GH19G046263 1 ENCODE 24.4 +338.1 338102 0.2 FEZF1 ELK1 FOS SP3 YY2 JUNB TSHZ1 TBX21 ZNF585B NBN ZC3H4 IRF2BP1 CCDC61 PPP5D1 NOVA2 HIF3A IGFL4 MIR769 PGLYRP1 PNMA8B
GH19G046600 1.4 ENCODE dbSUPER 15.5 -1.2 -1195 4.6 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 ZC3H4 IRF2BP1 ENSG00000268810 CCDC61 PPP5D1 ENSG00000269148 FBXO46 DM1-AS CCDC9 GNG8
GH19G047105 1.9 FANTOM5 ENCODE dbSUPER 11.1 -509.1 -509097 9.2 MLX CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF263 SP3 C5AR2 PRKD2 DHX34 ZC3H4 CCDC9 SNORD23 TMEM160 PPP5D1 C5AR1 ENSG00000268746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP5D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP5D1 Gene

Chromosome:
19
Start:
46,480,788 bp from pter
End:
46,601,200 bp from pter
Size:
120,413 bases
Orientation:
Minus strand

Genomic View for PPP5D1 Gene

Genes around PPP5D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP5D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP5D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP5D1 Gene

Proteins for PPP5D1 Gene

  • Protein details for PPP5D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7EU14-PP5D1_HUMAN
    Recommended name:
    Protein PPP5D1
    Protein Accession:
    E7EU14
    Secondary Accessions:
    • B3KSW5

    Protein attributes for PPP5D1 Gene

    Size:
    171 amino acids
    Molecular mass:
    19623 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shares sequence similarity with serine/threonine-protein phosphatase PPP5C. However, it is much shorter and does not contain the phosphatase catalytic region.

neXtProt entry for PPP5D1 Gene

Post-translational modifications for PPP5D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP5D1 Gene

No data available for DME Specific Peptides for PPP5D1 Gene

Domains & Families for PPP5D1 Gene

Gene Families for PPP5D1 Gene

Protein Domains for PPP5D1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E7EU14

UniProtKB/Swiss-Prot:

PP5D1_HUMAN :
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
genes like me logo Genes that share domains with PPP5D1: view

No data available for Suggested Antigen Peptide Sequences for PPP5D1 Gene

Function for PPP5D1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP5D1 Gene

Localization for PPP5D1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP5D1 gene
Compartment Confidence
mitochondrion 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP5D1 Gene

Pathways & Interactions for PPP5D1 Gene

SuperPathways for PPP5D1 Gene

SuperPathway Contained pathways
1 MAPK signaling pathway
genes like me logo Genes that share pathways with PPP5D1: view

Pathways by source for PPP5D1 Gene

1 KEGG pathway for PPP5D1 Gene

Interacting Proteins for PPP5D1 Gene

Gene Ontology (GO) - Biological Process for PPP5D1 Gene

None

No data available for SIGNOR curated interactions for PPP5D1 Gene

Drugs & Compounds for PPP5D1 Gene

No Compound Related Data Available

Transcripts for PPP5D1 Gene

mRNA/cDNA for PPP5D1 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP5D1 Gene

PPP5 tetratricopeptide repeat domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP5D1 Gene

No ASD Table

Relevant External Links for PPP5D1 Gene

GeneLoc Exon Structure for
PPP5D1
ECgene alternative splicing isoforms for
PPP5D1

Expression for PPP5D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP5D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP5D1 Gene:

PPP5D1

SOURCE GeneReport for Unigene cluster for PPP5D1 Gene:

Hs.671661

Evidence on tissue expression from TISSUES for PPP5D1 Gene

  • Stomach(3.1)
  • Nervous system(2.8)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with PPP5D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP5D1 Gene

Orthologs for PPP5D1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PPP5D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP5D1 35
  • 99 (a)
OneToOne
Species where no ortholog for PPP5D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPP5D1 Gene

ENSEMBL:
Gene Tree for PPP5D1 (if available)
TreeFam:
Gene Tree for PPP5D1 (if available)

Paralogs for PPP5D1 Gene

Pseudogenes.org Pseudogenes for PPP5D1 Gene

genes like me logo Genes that share paralogs with PPP5D1: view

No data available for Paralogs for PPP5D1 Gene

Variants for PPP5D1 Gene

Sequence variations from dbSNP and Humsavar for PPP5D1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000047928 -- 46,516,661(+) AGGGG(A/C)CTTGC intron-variant
rs1000070482 -- 46,589,574(+) GATCC(A/G)CCCGC intron-variant
rs1000071149 -- 46,548,303(+) AAATA(C/T)TTTTT intron-variant
rs1000082889 -- 46,568,361(+) GAAGC(C/T)CCTTC intron-variant
rs1000098799 -- 46,595,608(+) CAACA(A/C)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP5D1 Gene

Variant ID Type Subtype PubMed ID
esv2668998 CNV deletion 23128226
esv3415796 CNV insertion 20981092
esv3556483 CNV deletion 23714750
esv3583443 CNV loss 25503493
esv3644532 CNV loss 21293372
nsv527638 CNV loss 19592680
nsv833849 CNV loss 17160897
nsv978831 CNV duplication 23825009

Variation tolerance for PPP5D1 Gene

Gene Damage Index Score: 1.09; 22.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP5D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP5D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP5D1 Gene

Disorders for PPP5D1 Gene

Relevant External Links for PPP5D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP5D1

No disorders were found for PPP5D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP5D1 Gene

Publications for PPP5D1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for PPP5D1 Gene

Sources for PPP5D1 Gene

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