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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP5C Gene

protein-coding   GIFtS: 65
GCID: GC19P046850

Protein Phosphatase 5, Catalytic Subunit


(Previous symbol: PPP5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 5, Catalytic Subunit1 2     PP-T2 3
PPP51 2 3     PPT2 3
PP52 3 5     EC 3.1.3.163 8
Protein Phosphatase T2 3     Serine/Threonine-Protein Phosphatase 52

External Ids:    HGNC: 93221   Entrez Gene: 55362   Ensembl: ENSG000000114857   OMIM: 6006585   UniProtKB: P530413   

Export aliases for PPP5C gene to outside databases

Previous GC identifers: GC19P047494 GC19P047241 GC19P051526 GC19P051542 GC19P043278


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP5C Gene:
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit
family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and
threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The
product of this gene has been shown to participate in signaling pathways in response to hormones or cellular
stress, and elevated levels of this protein may be associated with breast cancer development. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Feb 2011)

GeneCards Summary for PPP5C Gene: 
PPP5C (protein phosphatase 5, catalytic subunit) is a protein-coding gene. Diseases associated with PPP5C include breast cancer, and retinal degeneration, and among its related super-pathways are MAPK signaling pathway and DNA Damage. GO annotations related to this gene include protein serine/threonine phosphatase activity and identical protein binding. An important paralog of this gene is PPEF2.

UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041
Function: May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine
residues of skeletal muscle phosphorylase and histone H1

Gene Wiki entry for PPP5C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP5C gene promoter:
         Spz1   SREBP-1a   AP-1   ATF-2   p300   c-Jun   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP5C promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP5C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

PPP5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP5C gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046850:  view genomic region     (about GC identifiers)

Start:
46,850,251 bp from pter      End:
46,896,238 bp from pter
Size:
45,988 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 5  
Size: 499 amino acids; 56879 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: Interacts with CDC16 and CDC27
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm
6/13 PDB 3D structures from and Proteopedia for PPP5C (see all 13):
1A17 (3D)        1S95 (3D)        1WAO (3D)        2BUG (3D)        3H60 (3D)        3H61 (3D)    
Secondary accessions: Q16722 Q53XV2

Explore the universe of human proteins at neXtProt for PPP5C: NX_P53041

Explore proteomics data for PPP5C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53041

  • 4/6 DME Specific Peptides for PPP5C (P53041) (see all 6)
     HGQFYDL  GDFVDRG  DLLWSDP  CGDTHGQ 

    PPP5C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP5C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001191213.1  NP_006238.1  

    ENSEMBL proteins: 
     ENSP00000012443   ENSP00000434329   ENSP00000375786  

    Human Recombinant Protein Products for PPP5C: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals PPP5C Protein
    Novus Biologicals PPP5C Lysates
    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPP5C 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol IEA--
    GO:0016020membrane IEA--

    PPP5C for ontologies           About GeneDecksing



    PPP5C Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    5/8 InterPro protein domains (see all 8):
     IPR011236 Ser/Thr_PPase_5
     IPR011990 TPR-like_helical
     IPR013235 PPP_dom
     IPR004843 Metallo_PEstase_dom
     IPR001440 TPR-1

    Graphical View of Domain Structure for InterPro Entry P53041

    ProtoNet protein and cluster: P53041

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041
    Similarity: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily
    Similarity: Contains 3 TPR repeats


    PPP5C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPP5_HUMAN, P53041
    Function: May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine
    residues of skeletal muscle phosphorylase and histone H1
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for PPP5C:
    serine/threorine phosphatase 5,catalytic subunit,ubiquitously expressed,not involved as tumor suppressor gene in
    glioma

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ISS9383998
    GO:0004722protein serine/threonine phosphatase activity TAS7925273
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI11504734
    GO:0008289lipid binding IEA--
         
    PPP5C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP5C:
     Decreased viability 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ppp5c):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  no phenotypic analysis  normal  reproductive system 
     skeleton 

    PPP5C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PPP5C: Ppp5ctm1Lex Ppp5ctm1.2Rhon

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP5C 
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP5C 

    miRNA
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    miRTarBase miRNAs that target PPP5C:
    hsa-mir-155 (MIRT001518)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP5C
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP5C (see all 22):
    hsa-miR-548j hsa-miR-137 hsa-miR-520d-5p hsa-miR-548i hsa-miR-3143 hsa-miR-193a-5p hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPP5C 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP5C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP5C About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2DNA Damage
    Cell Cycle / Checkpoint Control0.32
    3Meiosis
    Meiosis
    4Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network
    5ErbB1 downstream signaling
    ErbB1 downstream signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PPP5C
        Meiosis


    2 Cell Signaling Technology (CST) Pathways for PPP5C
        Phosphatases
    Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for PPP5C
        MAPK signaling pathway
    Glucocorticoid receptor regulatory network
    ErbB1 downstream signaling



    1         Kegg Pathway  (Kegg details for PPP5C):
        MAPK signaling pathway


    PPP5C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for PPP5C (P530411, 2, 3 ENSP000000124434) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000215328P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000224501P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000231555P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000234475P081072, 3MINT-8204077 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006351transcription, DNA-dependent TAS7925273
    GO:0006470protein dephosphorylation IEA--
    GO:0007067mitosis TAS7925273
    GO:0007165signal transduction IMP12761501

    PPP5C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP5C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP5C (PPP5)

    5 HMDB Compounds for PPP5C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    9 Novoseek inferred chemical compound relationships for PPP5C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 74.4 27 11389770 (2), 15374638 (2), 18253812 (2), 12519780 (1) (see all 20)
    serine 64.1 27 7925273 (2), 11389770 (2), 15374638 (2), 18253812 (2) (see all 19)
    p-nitrophenyl phosphate 60.3 1 15890660 (1)
    okadaic acid 53.3 3 7925273 (1), 15890660 (1)
    arachidonic acid 40.6 8 19404779 (2), 15577939 (2), 14690518 (1), 9000529 (1) (see all 6)
    rapamycin 27 8 15218033 (5), 18280813 (1)
    tacrolimus 12.3 6 9195923 (4)
    lipid 0 2 10471836 (1), 18547097 (1)
    fatty acid 0 2 11969423 (1), 11523989 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP5C / PPP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP5C gene (2 alternative transcripts): 
    NM_001204284.1  NM_006247.3  

    Unigene Cluster for PPP5C:

    Protein phosphatase 5, catalytic subunit
    Hs.654604  [show with all ESTs]
    Unigene Representative Sequence: AB209615
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000012443(uc002pem.3 uc002pen.3 uc010xya.2) ENST00000478046
    ENST00000391919 ENST00000467902 ENST00000527193 ENST00000487483(uc010xyb.1)
    ENST00000532058 ENST00000486994 ENST00000467502 ENST00000493347 ENST00000595055
    ENST00000491003 ENST00000492109 ENST00000525507 ENST00000527623

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    Additional mRNA sequence: 

    AB209615.1 AK094241.1 AK223222.1 AK293402.1 AK293475.1 AK297095.1 AK312683.1 BC000750.2 
    BC001831.2 BC001970.1 BT007275.1 U25174.1 X89416.1 X92121.1 

    18 DOTS entries:

    DT.102828793  DT.446391  DT.97854807  DT.95263432  DT.121505135  DT.97767914  DT.121505084  DT.95263436 
    DT.100884187  DT.100884175  DT.100884183  DT.121505106  DT.121505088  DT.40271984  DT.92449140  DT.100884172 
    DT.100884185  DT.92449137 

    24/484 AceView cDNA sequences (see all 484):

    T16486 BF221783 AL533744 BC001970 CK903754 AW004772 BU943482 BM456322 
    AW328686 CR624518 BE867480 CF131315 BG743563 BG755187 BF725389 BE293700 
    R18874 BG478878 BU625995 CR609801 BU197206 BG762007 BE293553 BE727847 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PPP5C (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^
    SP1:                                -                             -     -     -     -                 -                 -     -           -                     
    SP2:                                -                             -     -     -     -                 -                 -     -           -                     
    SP3:                                                                                                  -                 -     -           -                     
    SP4:                                                                                                                    -     -           -                     
    SP5:                                -                             -     -     -     -     -     -     -                 -     -           -                     

    ExUns: 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
    SP1:                    -     -     -     -               
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for PPP5C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGCTAG
    PPP5C Expression
    About this image


    See PPP5C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP5C

    SOURCE GeneReport for Unigene cluster: Hs.654604

    UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including PPP5C: 
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP5C gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp5c1 , 5 protein phosphatase 5, catalytic subunit1, 5 91.05(n)1
    97.8(a)1
      7 (9.15 cM)5
    190601  NM_011155.21  NP_035285.21 
     170046405 
    lizard
    (Anolis carolinensis)
    Reptilia PPP5C6
    Serine/threonine-protein phosphatase
    89(a)
    1 ↔ 1
    GL343568.1(251755-280380)
    African clawed frog
    (Xenopus laevis)
    Amphibia PP52 protein phosphatase 5 74.14(n)    AF018263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1108011 zgc:110801 76.27(n)
    84.53(a)
      541536  NM_001014350.2  NP_001014372.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta PpD31 , 3 protein amino acid dephosphorylation
    protein serine/threonine more3
    Protein phosphatase D31
    63(a)3
    64.38(n)1
    63.17(a)1
      85E63
    497791  NM_080207.21  NP_524946.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39B6A.23
    pph-51
    Protein PPH-51 55(a)3
    57.75(n)1
    59.58(a)1
      V(19187234-19195602)3
    1802631  NM_171607.31  NP_741697.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPT1(YGR123C)4
    PPT11
    Protein serine/threonine phosphatase with similarity more4
    Ppt1p1
    48.1(n)1
    44.52(a)1
      7(738203-736662)4
    8530231, 4  NP_011639.31  NP_011639.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PP5.21 serine/threonine-protein phosphatase 5 57.63(n)
    56.57(a)
      818881  NM_129842.3  NP_565985.1 
    rice
    (Oryza sativa)
    Liliopsida Os.195582 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.67(n)    AK102966.1 


    ENSEMBL Gene Tree for PPP5C (if available)
    TreeFam Gene Tree for PPP5C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP5C gene
    PPEF22  PPEF12  
    13 SIMAP similar genes for PPP5C using alignment to 4 protein entries:     PPP5_HUMAN (see all proteins):
    PPP5D1    PPP2CA    PPP2CB    PPP4C    PPP6C    PPP1CC
    PPP1CA    PPP1CB    PPP3CC    PPP3CB    PPP3CA    SGTB
    PPEF1

    PPP5C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1013 SNPs in PPP5C are shown (see all 1013)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463933111,2
    C,Funtested147080983(+) AACACG/ACTGCT 4 /T syn11Minor allele frequency- A:0.00NA 3924
    rs2007779441,2
    C--46851197(+) AAAAA-/ACAAAA 2 -- int10--------
    rs30633961,2
    C--46854006(+) CGGAG-/AAGTGAA 2 -- int10--------
    rs797211901,2
    --46854007(+) GGAGAA/GGTGAA 2 -- int10--------
    rs1129269371,2
    C,F--46855873(+) GAGATC/TGAGAC 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs81117841,2
    C,F,A,H--46858539(+) CCCCCC/GACACA 2 -- int15Minor allele frequency- G:0.30NA WA 10
    rs669398621,2
    C--46858539(+) CCCCC-/GACACA 2 -- int10--------
    rs558790151,2
    C--46863053(+) TTTTT-/T/TT  
            
    GAGGC
    2 -- int11NA 2
    rs590902211,2
    C--46864404(+) TTTTT-/TTT   
       
    /TTTT
    GAGAC
    4 -- int1 cds11NA 2
    rs1116754871,2
    C,F--46866392(+) AACCCC/TGTCTC 2 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for PPP5C (46850251 - 46896238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PPP5C:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718654CNV Deletion23290073
    nsv138470CNV Loss16902084
    nsv912185CNV Loss21882294
    nsv912183CNV Loss21882294
    nsv912184CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600658    OMIM disorders: --

    9 diseases for PPP5C:    About MalaCards
    breast cancer    retinal degeneration    alzheimer's disease    retinitis
    kaposi's sarcoma    schizophrenia    hypoxia    sarcoma
    neuronitis


    PPP5C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for PPP5C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 25.3 4 11969423 (1), 15967796 (1), 11523989 (1)
    alzheimers disease 7.95 3 19404779 (1), 15546861 (1), 14690518 (1)
    tumors 0 16 15374638 (4), 18280813 (2), 11240142 (1), 9575175 (1)
    cancer 0 8 18280813 (1), 10413457 (1), 15374638 (1), 18253812 (1) (see all 5)


    Export disorders for PPP5C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP5C gene, integrated from 9 sources (see all 121):
    (articles sorted by number of sources associating them with PPP5C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3. (PubMed id 8666404)1, 2, 3 Yong W.H.... Louis D.N. (1995)
    2. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex. (PubMed id 9405394)1, 2, 9 Ollendorff V. and Donoghue D.J. (1997)
    3. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. (PubMed id 7925273)1, 2, 9 Chen M.X....Cohen P.T.W. (1994)
    4. Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene. (PubMed id 8561788)1, 2, 9 Xu X....Zetterberg A. (1996)
    5. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. (PubMed id 9482716)1, 2, 9 Das A.K.... Barford D. (1998)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. (PubMed id 18280813)1, 9 Golden T....Honkanen R.E. (2008)
    9. Activated Rac1 GTPase translocates protein phosphatas e 5 to the cell membrane and stimulates phosphatase activity in vitro. (PubMed id 19948726)1, 9 Chatterjee A....Rossie S. (2010)
    10. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. (PubMed id 9195923)1, 9 Silverstein A.M....Pratt W.B. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5536 HGNC: 9322 AceView: PPP5C Ensembl:ENSG00000011485 euGenes: HUgn5536
    ECgene: PPP5C Kegg: 5536 H-InvDB: PPP5C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP5C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP5C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP5C gene:
    Search GeneIP for patents involving PPP5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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