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PPP5C Gene

protein-coding   GIFtS: 66
GCID: GC19P046850

Protein Phosphatase 5, Catalytic Subunit


(Previous symbol: PPP5)
  See PPP5C-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 5, Catalytic Subunit1 2     PP-T2 3
PPP51 2 3     PPT2 3
PP52 3 5     EC 3.1.3.163 8
Protein Phosphatase T2 3     Serine/Threonine-Protein Phosphatase 52

External Ids:    HGNC: 93221   Entrez Gene: 55362   Ensembl: ENSG000000114857   OMIM: 6006585   UniProtKB: P530413   

Export aliases for PPP5C gene to outside databases

Previous GC identifers: GC19P047494 GC19P047241 GC19P051526 GC19P051542 GC19P043278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP5C Gene:
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit
family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and
threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The
product of this gene has been shown to participate in signaling pathways in response to hormones or cellular
stress, and elevated levels of this protein may be associated with breast cancer development. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Feb 2011)

GeneCards Summary for PPP5C Gene:
PPP5C (protein phosphatase 5, catalytic subunit) is a protein-coding gene. Diseases associated with PPP5C include breast cancer. GO annotations related to this gene include lipid binding and identical protein binding. An important paralog of this gene is PPEF2.

UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041
Function: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different
signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG,
ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis,
differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response
to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses.
Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair
through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits
ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through
the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the
anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of
CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression
levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may
play a role in the regulation of ions channels such as KCNH2

Gene Wiki entry for PPP5C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP5C gene promoter:
         Spz1   SREBP-1a   AP-1   ATF-2   p300   c-Jun   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP5C promoter sequence
   Search Chromatin IP Primers for PPP5C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

PPP5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP5C gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046850:  view genomic region     (about GC identifiers)

Start:
46,850,251 bp from pter      End:
46,896,238 bp from pter
Size:
45,988 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 5  
Size: 499 amino acids; 56879 Da
Cofactor: Binds 2 divalent metal cation per subutnit
Subunit: Part of a complex with HSP90/HSP90AA1 and steroid receptors. Interacts with CDC16, CDC27. Interacts with
KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5. Interacts (via TPR repeats) with
HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase
activity. Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid. Interacts with ATM and
ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity. Interacts with RAD17;
reduced by DNA damage. Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist);
regulates their transactivation activities. Interacts (via TPR repeats) with S100 proteins S100A1, S100A2,
S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and
compete with HSP90AA1 and MAP3K5 interactions. Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3
phosphorylation and protein levels. Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2
downregulates the phosphatase activity on CSNK1E. Interacts (via TPR repeats) with the active form of RAC1, GNA12
or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane
Selected PDB 3D structures from and Proteopedia for PPP5C (see all 13):
1A17 (3D)        1S95 (3D)        1WAO (3D)        2BUG (3D)        3H60 (3D)        3H61 (3D)    
Secondary accessions: Q16722 Q53XV2

Explore the universe of human proteins at neXtProt for PPP5C: NX_P53041

Explore proteomics data for PPP5C at MOPED

Post-translational modifications: 

  • Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form1
  • Ubiquitination2 at Lys32, Lys412
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP5C (P53041) (see all 6)
     HGQFYDL  GDFVDRG  DLLWSDP  CGDTHGQ 


    See PPP5C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001191213.1  NP_006238.1  

    ENSEMBL proteins: 
     ENSP00000012443   ENSP00000434329   ENSP00000375786  

    PPP5C Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PPP5C

     
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    PPP5C Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    Selected InterPro protein domains (see all 8):
     IPR011236 Ser/Thr_PPase_5
     IPR011990 TPR-like_helical
     IPR013235 PPP_dom
     IPR004843 PEstase_dom
     IPR001440 TPR_1

    Graphical View of Domain Structure for InterPro Entry P53041

    ProtoNet protein and cluster: P53041

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041
    Similarity: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with PPP5C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPP5_HUMAN, P53041
    Function: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different
    signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG,
    ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis,
    differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response
    to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses.
    Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair
    through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits
    ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through
    the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the
    anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of
    CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression
    levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may
    play a role in the regulation of ions channels such as KCNH2
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Enzyme regulation: Autoinhibited. The TPR domain, unique in that protein family, engage to form an extensive
    interface with the catalytic region preventig access of the substrate to the catalytic pocket. Allosterically
    activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA
    esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also
    release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one
    produced by fatty acids binding. Inhibited by okadaic acid
    Biophysicochemical properties: Kinetic parameters: KM=1.847 uM for CSNK1E (at 30 degrees Celsius); KM=13.2 uM for
    MAPT/TAU (at pH 7.4 and 30 degrees Celsius);

         Genatlas biochemistry entry for PPP5C:
    serine/threorine phosphatase 5,catalytic subunit,ubiquitously expressed,not involved as tumor suppressor gene in
    glioma

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004721phosphoprotein phosphatase activity ISS9383998
    GO:0004722protein serine/threonine phosphatase activity TAS7925273
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI11504734
         
    Find genes that share ontologies with PPP5C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP5C:
     Decreased viability 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ppp5c):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  no phenotypic analysis  normal  reproductive system 
     skeleton 

    Find genes that share phenotypes with PPP5C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PPP5C: Ppp5ctm1Lex Ppp5ctm1.2Rhon

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP5C
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP5C

    miRNA
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    miRTarBase miRNAs that target PPP5C:
    hsa-mir-615-3p (MIRT039894), hsa-mir-99b-3p (MIRT038528), hsa-mir-155-5p (MIRT001518)

    Block miRNA regulation of human, mouse, rat PPP5C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP5C (see all 22):
    hsa-miR-548j hsa-miR-137 hsa-miR-520d-5p hsa-miR-548i hsa-miR-3143 hsa-miR-193a-5p hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPP5C 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPP5_HUMAN, P53041: Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3
    cytoskeleton2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol IEA--

    Find genes that share ontologies with PPP5C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP5C About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Phosphatases
    Phosphatases
    4Meiosis (EMD)
    Meiosis
    5Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network


    Find genes that share SuperPaths with PPP5C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PPP5C
        Phosphatases
    Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for PPP5C
        MAPK signaling pathway
    Glucocorticoid receptor regulatory network
    ErbB1 downstream signaling



    1 Kegg Pathway  (Kegg details for PPP5C):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including PPP5C: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP5C (P530411, 2, 3 ENSP000000124434) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000215328P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000224501P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000231555P081072, 3MINT-8204077 I2D: score=1 
    ENSG00000234475P081072, 3MINT-8204077 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006351transcription, DNA-templated TAS7925273
    GO:0006470protein dephosphorylation IEA--
    GO:0007067mitosis TAS7925273
    GO:0007165signal transduction IMP12761501

    Find genes that share ontologies with PPP5C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP5C (PPP5)

    5 HMDB Compounds for PPP5C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    9 Novoseek inferred chemical compound relationships for PPP5C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 74.4 27 11389770 (2), 15374638 (2), 18253812 (2), 12519780 (1) (see all 20)
    serine 64.1 27 7925273 (2), 11389770 (2), 15374638 (2), 18253812 (2) (see all 19)
    p-nitrophenyl phosphate 60.3 1 15890660 (1)
    okadaic acid 53.3 3 7925273 (1), 15890660 (1)
    arachidonic acid 40.6 8 19404779 (2), 15577939 (2), 14690518 (1), 9000529 (1) (see all 6)
    rapamycin 27 8 15218033 (5), 18280813 (1)
    tacrolimus 12.3 6 9195923 (4)
    lipid 0 2 10471836 (1), 18547097 (1)
    fatty acid 0 2 11969423 (1), 11523989 (1)



    Find genes that share compounds with PPP5C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP5C gene (2 alternative transcripts): 
    NM_001204284.1  NM_006247.3  

    Unigene Cluster for PPP5C:

    Protein phosphatase 5, catalytic subunit
    Hs.654604  [show with all ESTs]
    Unigene Representative Sequence: AB209615
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000012443(uc002pem.3 uc002pen.3 uc010xya.2) ENST00000478046
    ENST00000391919 ENST00000467902 ENST00000527193 ENST00000487483(uc010xyb.1)
    ENST00000532058 ENST00000486994 ENST00000467502 ENST00000493347 ENST00000595055
    ENST00000491003 ENST00000492109 ENST00000525507 ENST00000527623
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    Selected qRT-PCR Assays for microRNAs that regulate PPP5C (see all 22):
    hsa-miR-548j hsa-miR-137 hsa-miR-520d-5p hsa-miR-548i hsa-miR-3143 hsa-miR-193a-5p hsa-miR-548a-5p hsa-miR-548d-5p
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    Additional mRNA sequence: 

    AB209615.1 AK094241.1 AK223222.1 AK293402.1 AK293475.1 AK297095.1 AK312683.1 BC000750.2 
    BC001831.2 BC001970.1 BT007275.1 U25174.1 X89416.1 X92121.1 

    18 DOTS entries:

    DT.102828793  DT.446391  DT.97854807  DT.95263432  DT.121505135  DT.97767914  DT.121505084  DT.95263436 
    DT.100884187  DT.100884175  DT.100884183  DT.121505106  DT.121505088  DT.40271984  DT.92449140  DT.100884172 
    DT.100884185  DT.92449137 

    Selected AceView cDNA sequences (see all 484):

    X89416 BU845520 CB853519 BM726016 BM703840 BQ086290 BG769002 BM456322 
    AI131448 BF844758 CF132366 BE249858 BQ652048 BQ012794 BU943482 CA489216 
    AA023029 CR609801 CD622245 BE727782 BG755187 AI084139 BM550860 BG762007 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP5C (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^
    SP1:                                -                             -     -     -     -                 -                 -     -           -                     
    SP2:                                -                             -     -     -     -                 -                 -     -           -                     
    SP3:                                                                                                  -                 -     -           -                     
    SP4:                                                                                                                    -     -           -                     
    SP5:                                -                             -     -     -     -     -     -     -                 -     -           -                     

    ExUns: 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
    SP1:                    -     -     -     -               
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for PPP5C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPP5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGCTAG
    PPP5C Expression
    About this image


    PPP5C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    PPP5C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP5C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654604

    UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including PPP5C: 
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP5C gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp5c1 , 5 protein phosphatase 5, catalytic subunit1, 5 91.05(n)1
    97.8(a)1
      7 (9.15 cM)5
    190601  NM_011155.21  NP_035285.21 
     170046405 
    lizard
    (Anolis carolinensis)
    Reptilia PPP5C6
    protein phosphatase 5, catalytic subunit
    88(a)
    1 ↔ 1
    GL343568.1(251755-280380)
    African clawed frog
    (Xenopus laevis)
    Amphibia PP52 protein phosphatase 5 74.14(n)    AF018263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp5c1 protein phosphatase 5, catalytic subunit 76.27(n)
    84.53(a)
      541536  NM_001014350.2  NP_001014372.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta PpD31 , 3 protein amino acid dephosphorylation
    protein serine/threonine more3
    Protein phosphatase D31
    63(a)3
    64.38(n)1
    63.17(a)1
      85E63
    497791  NM_080207.21  NP_524946.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39B6A.23
    pph-51
    pph-51 55(a)3
    57.96(n)1
    60.39(a)1
      V(19187234-19195602)3
    1802631  NM_001269920.11  NP_001256849.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPT1(YGR123C)4
    PPT11
    Protein serine/threonine phosphatase with similarity more4
    PPT11
    47.67(n)1
    43.01(a)1
      7(738203-736662)4
    8530231, 4  NP_011639.31  NP_011639.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PP5.21 PP5.2 57.63(n)
    56.57(a)
      818881  NM_129842.3  NP_565985.1 
    rice
    (Oryza sativa)
    Liliopsida Os.195582 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.67(n)    AK102966.1 


    ENSEMBL Gene Tree for PPP5C (if available)
    TreeFam Gene Tree for PPP5C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for PPP5C gene
    PPEF22  PPEF12  
    14 SIMAP similar genes for PPP5C using alignment to 4 protein entries:     PPP5_HUMAN (see all proteins):
    PPP5D1    PPP2CA    PPP2CB    PPP1CC    PPP4C    PPP6C
    PPP1CA    PPP1CB    DNAJC7    PPP3CC    PPP3CB    PPP3CA
    SGTB    PPEF1

    Find genes that share paralogs with PPP5C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PPP5C (see all 1013)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463933111,2
    C,Funtested147080983(+) AACACG/ACTGCT 4 /T syn11Minor allele frequency- A:0.00NA 3924
    rs2007779441,2
    C--46851197(+) AAAAA-/ACAAAA 2 -- int10--------
    rs30633961,2
    C--46854006(+) CGGAG-/AAGTGAA 2 -- int10--------
    rs797211901,2
    --46854007(+) GGAGAA/GGTGAA 2 -- int10--------
    rs1129269371,2
    C,F--46855873(+) GAGATC/TGAGAC 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs81117841,2
    C,F,A,H--46858539(+) CCCCCC/GACACA 2 -- int15Minor allele frequency- G:0.30NA WA 10
    rs669398621,2
    C--46858539(+) CCCCC-/GACACA 2 -- int10--------
    rs558790151,2
    C--46863053(+) TTTTT-/T/TT  
            
    GAGGC
    2 -- int11NA 2
    rs590902211,2
    C--46864404(+) TTTTT-/TTT   
       
    /TTTT
    GAGAC
    4 -- int1 cds11NA 2
    rs1116754871,2
    C,F--46866392(+) AACCCC/TGTCTC 2 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for PPP5C (46850251 - 46896238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PPP5C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718654CNV Deletion23290073
    nsv138470CNV Loss16902084
    nsv912185CNV Loss21882294
    nsv912183CNV Loss21882294
    nsv912184CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP5C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600658    OMIM disorders: --

    1 disease for PPP5C:    
    About MalaCards
    breast cancer


    Find genes that share disorders with PPP5C           About GenesLikeMe

    4 Novoseek inferred disease relationships for PPP5C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 25.3 4 11969423 (1), 15967796 (1), 11523989 (1)
    alzheimers disease 7.95 3 19404779 (1), 15546861 (1), 14690518 (1)
    tumors 0 16 15374638 (4), 18280813 (2), 11240142 (1), 9575175 (1)
    cancer 0 8 18280813 (1), 10413457 (1), 15374638 (1), 18253812 (1) (see all 5)


    Export disorders for PPP5C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP5C gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with PPP5C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3. (PubMed id 8666404)1, 2, 3 Yong W.H.... Louis D.N. (Genomics 1995)
    2. Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. (PubMed id 19948726)1, 2, 9 Chatterjee A....Rossie S. (J. Biol. Chem. 2010)
    3. Protein phosphatase 5 is required for ATR-mediated checkpoint activation. (PubMed id 16260606)1, 2, 9 Zhang J....Wang X.F. (Mol. Cell. Biol. 2005)
    4. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex. (PubMed id 9405394)1, 2, 9 Ollendorff V. and Donoghue D.J. (J. Biol. Chem. 1997)
    5. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. (PubMed id 7925273)1, 2, 9 Chen M.X....Cohen P.T.W. (EMBO J. 1994)
    6. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. (PubMed id 16790549)1, 2, 9 Partch C.L....Sancar A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    7. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. (PubMed id 15577939)1, 2, 9 Yang J....Barford D. (EMBO J. 2005)
    8. Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene. (PubMed id 8561788)1, 2, 9 Xu X....Zetterberg A. (Biochem. Biophys. Res. Commun. 1996)
    9. Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. (PubMed id 16892053)1, 2, 9 von Kriegsheim A....Dhillon A.S. (Nat. Cell Biol. 2006)
    10. Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5. (PubMed id 15155720)1, 2, 9 Swingle M.R....Ciszak E.M. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5536 HGNC: 9322 AceView: PPP5C Ensembl:ENSG00000011485 euGenes: HUgn5536
    ECgene: PPP5C Kegg: 5536 H-InvDB: PPP5C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP5C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP5C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP5C gene:
    Search GeneIP for patents involving PPP5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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