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Aliases for PPP5C Gene

Aliases for PPP5C Gene

  • Protein Phosphatase 5 Catalytic Subunit 2 3 5
  • Protein Phosphatase T 3 4
  • EC 3.1.3.16 4 58
  • PPP5 3 4
  • PP-T 3 4
  • PP5 3 4
  • PPT 3 4
  • Protein Phosphatase 5, Catalytic Subunit 2
  • Serine/Threonine-Protein Phosphatase 5 3

External Ids for PPP5C Gene

Previous HGNC Symbols for PPP5C Gene

  • PPP5

Previous GeneCards Identifiers for PPP5C Gene

  • GC19P047494
  • GC19P047241
  • GC19P051526
  • GC19P051542
  • GC19P046850
  • GC19P043278

Summaries for PPP5C Gene

Entrez Gene Summary for PPP5C Gene

  • This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

GeneCards Summary for PPP5C Gene

PPP5C (Protein Phosphatase 5 Catalytic Subunit) is a Protein Coding gene. Among its related pathways are DNA Damage and RET signaling. GO annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is PPEF2.

UniProtKB/Swiss-Prot for PPP5C Gene

  • Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Gene Wiki entry for PPP5C Gene

Additional gene information for PPP5C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP5C Gene

Genomics for PPP5C Gene

Regulatory Elements for PPP5C Gene

Enhancers for PPP5C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H046349 1.4 FANTOM5 Ensembl ENCODE 42.3 +3.9 3932 3.3 KLF1 SIN3A KLF17 MAX EBF1 ZIC2 RELA E2F1 ZNF316 POLR2A PPP5C ENSG00000268810 PRKD2
GH19H046371 1.4 FANTOM5 Ensembl ENCODE 37.4 +26.1 26094 3.9 HDGF CTCF KLF1 NFIB SIN3A MAX ZIC2 RAD21 ZBTB7B ZFHX2 PPP5C HIF3A ENSG00000268810
GH19H046390 1.1 Ensembl ENCODE dbSUPER 45.1 +45.1 45135 2.9 GLIS1 ZNF10 MAX ZNF600 ZBTB33 ZIC2 MYC PPP5C GC19M046372 GC19M046401
GH19H046345 1.1 ENCODE 43 +0.0 42 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 PPP5C ENSG00000268810 ZC3H4 INAFM1 QPCTL BHMG1 ERCC1
GH19H046354 0.9 ENCODE 47.4 +8.5 8506 2.4 ARID4B DMAP1 THRB RARA YY1 MIXL1 THAP11 SP5 CEBPB REST PPP5C ENSG00000268810
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP5C on UCSC Golden Path with GeneCards custom track

Promoters for PPP5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110348 306 1401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Locations for PPP5C Gene

Genomic Locations for PPP5C Gene
chr19:46,346,994-46,392,981
(GRCh38/hg38)
Size:
45,988 bases
Orientation:
Plus strand
chr19:46,850,251-46,896,238
(GRCh37/hg19)

Genomic View for PPP5C Gene

Genes around PPP5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP5C Gene

Proteins for PPP5C Gene

  • Protein details for PPP5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53041-PPP5_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 5
    Protein Accession:
    P53041
    Secondary Accessions:
    • Q16722
    • Q53XV2

    Protein attributes for PPP5C Gene

    Size:
    499 amino acids
    Molecular mass:
    56879 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with CPNE1 (via VWFA domain) (By similarity). Part of a complex with HSP90/HSP90AA1 and steroid receptors. Interacts with CDC16, CDC27. Interacts with KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5. Interacts (via TPR repeats) with HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase activity. Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid. Interacts with ATM and ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity. Interacts with RAD17; reduced by DNA damage. Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist); regulates their transactivation activities. Interacts (via TPR repeats) with S100 proteins S100A1, S100A2, S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and compete with HSP90AA1 and MAP3K5 interactions. Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3 phosphorylation and protein levels. Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2 downregulates the phosphatase activity on CSNK1E. Interacts (via TPR repeats) with the active form of RAC1, GNA12 or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane. Interacts with FLCN (PubMed:27353360).

    Three dimensional structures from OCA and Proteopedia for PPP5C Gene

neXtProt entry for PPP5C Gene

Selected DME Specific Peptides for PPP5C Gene

P53041:
  • GDFVDRG
  • DLLWSDP
  • GSDLRPQFHQFTAVPHPNVKPMAYAN
  • TVFSAPNYC
  • CGDTHGQ
  • HGQFYDL

Post-translational modifications for PPP5C Gene

  • Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.
  • Ubiquitination at posLast=3232 and posLast=412412
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP5C Gene

Domains & Families for PPP5C Gene

Gene Families for PPP5C Gene

Graphical View of Domain Structure for InterPro Entry

P53041

UniProtKB/Swiss-Prot:

PPP5_HUMAN :
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
genes like me logo Genes that share domains with PPP5C: view

Function for PPP5C Gene

Molecular function for PPP5C Gene

GENATLAS Biochemistry:
serine/threorine phosphatase 5,catalytic subunit,ubiquitously expressed,not involved as tumor suppressor gene in glioma
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.847 uM for CSNK1E (at 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549}; KM=13.2 uM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549};
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Enzyme Numbers (IUBMB) for PPP5C Gene

Phenotypes From GWAS Catalog for PPP5C Gene

Gene Ontology (GO) - Molecular Function for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0003723 RNA binding IEA --
GO:0004721 phosphoprotein phosphatase activity ISS,IEA 9383998
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with PPP5C: view
genes like me logo Genes that share phenotypes with PPP5C: view

Animal Models for PPP5C Gene

MGI Knock Outs for PPP5C:

Animal Model Products

CRISPR Products

miRNA for PPP5C Gene

miRTarBase miRNAs that target PPP5C

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP5C Gene

Localization for PPP5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP5C Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). {ECO:0000269 PubMed:15383005, ECO:0000269 PubMed:19948726}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP5C gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7925273
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PPP5C: view

Pathways & Interactions for PPP5C Gene

SuperPathways for PPP5C Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 DNA Double Strand Break Response
genes like me logo Genes that share pathways with PPP5C: view

Pathways by source for PPP5C Gene

SIGNOR curated interactions for PPP5C Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000278 mitotic cell cycle TAS 7925273
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated TAS 7925273
genes like me logo Genes that share ontologies with PPP5C: view

Drugs & Compounds for PPP5C Gene

(12) Drugs for PPP5C Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 35
ATP Nutra Agonist, Target 0
Fumonisin B1 Pharma PP5/PP2Cα/PP2A/PP1γ2/PP2B inhibitor 0

(5) Additional Compounds for PPP5C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(1) ApexBio Compounds for PPP5C Gene

Compound Action Cas Number
Fumonisin B1 PP5/PP2Cα/PP2A/PP1γ2/PP2B inhibitor 116355-83-0
genes like me logo Genes that share compounds with PPP5C: view

Drug Products

Transcripts for PPP5C Gene

Unigene Clusters for PPP5C Gene

Protein phosphatase 5, catalytic subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP5C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: - - - -
SP12: -
SP13: - -

ExUns: 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP5C Gene

GeneLoc Exon Structure for
PPP5C
ECgene alternative splicing isoforms for
PPP5C

Expression for PPP5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP5C Gene

This gene is overexpressed in Lymph node (8.5) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP5C Gene



Protein tissue co-expression partners for PPP5C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP5C Gene:

PPP5C

SOURCE GeneReport for Unigene cluster for PPP5C Gene:

Hs.654604

mRNA Expression by UniProt/SwissProt for PPP5C Gene:

P53041-PPP5_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PPP5C Gene

  • Nervous system(4.9)
  • Skin(3.4)
  • Lung(2.7)
  • Intestine(2.2)
  • Heart(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PPP5C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP5C Gene

Orthologs for PPP5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP5C 33 34
  • 99.2 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP5C 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP5C 33 34
  • 92.85 (n)
dog
(Canis familiaris)
Mammalia PPP5C 33 34
  • 91.65 (n)
mouse
(Mus musculus)
Mammalia Ppp5c 33 16 34
  • 91.05 (n)
rat
(Rattus norvegicus)
Mammalia Ppp5c 33
  • 90.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP5C 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP5C 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp5c 33
  • 69.98 (n)
Str.1816 33
African clawed frog
(Xenopus laevis)
Amphibia PP5 33
zebrafish
(Danio rerio)
Actinopterygii ppp5c 33 34
  • 76.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta PpD3 35 33 34
  • 64.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004151 33
  • 63.6 (n)
worm
(Caenorhabditis elegans)
Secernentea pph-5 33 34
  • 57.96 (n)
Y39B6A.2 35
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR083C 33
  • 55.17 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10912g 33
  • 50.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPT1 33 34 36
  • 47.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PP5.2 33
  • 57.63 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6044 33
rice
(Oryza sativa)
Liliopsida Os05g0204900 33
  • 57.68 (n)
Os.19558 33
corn
(Zea mays)
Liliopsida Zm.15554 33
bread mold
(Neurospora crassa)
Ascomycetes NCU01433 33
  • 58.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5196 34
  • 54 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3F6.01c 33
  • 50.79 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6199 33
Species where no ortholog for PPP5C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP5C Gene

ENSEMBL:
Gene Tree for PPP5C (if available)
TreeFam:
Gene Tree for PPP5C (if available)

Paralogs for PPP5C Gene

Paralogs for PPP5C Gene

(14) SIMAP similar genes for PPP5C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPP5C: view

Variants for PPP5C Gene

Sequence variations from dbSNP and Humsavar for PPP5C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000002479 -- 46,355,093(+) CACCT(G/T)CCCAG intron-variant
rs1000112174 -- 46,361,305(+) TTTGT(A/G)TTTTT intron-variant
rs1000138893 -- 46,346,494(+) TCAGG(A/T)CTTGA upstream-variant-2KB
rs1000295330 -- 46,383,182(+) GGTTT(C/T)CGTAC intron-variant
rs1000365748 -- 46,345,227(+) TAAAA(G/T)TACTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP5C Gene

Variant ID Type Subtype PubMed ID
nsv475904 CNV novel sequence insertion 20440878
nsv138470 CNV deletion 16902084
esv3556479 CNV deletion 23714750
esv2718654 CNV deletion 23290073

Variation tolerance for PPP5C Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP5C Gene

Disorders for PPP5C Gene

Relevant External Links for PPP5C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP5C

No disorders were found for PPP5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP5C Gene

Publications for PPP5C Gene

  1. Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. (PMID: 19948726) Chatterjee A … Rossie S (The Journal of biological chemistry 2010) 3 4 22 60
  2. Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. (PMID: 16892053) von Kriegsheim A … Dhillon AS (Nature cell biology 2006) 3 4 22 60
  3. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. (PMID: 16790549) Partch CL … Sancar A (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 60
  4. Protein phosphatase 5 is required for ATR-mediated checkpoint activation. (PMID: 16260606) Zhang J … Wang XF (Molecular and cellular biology 2005) 3 4 22 60
  5. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. (PMID: 15577939) Yang J … Barford D (The EMBO journal 2005) 3 4 22 60

Products for PPP5C Gene

Sources for PPP5C Gene

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