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Aliases for PPP5C Gene

Aliases for PPP5C Gene

  • Protein Phosphatase 5, Catalytic Subunit 2 3
  • PP5 3 4 6
  • Protein Phosphatase T 3 4
  • EC 3.1.3.16 4 64
  • PPP5 3 4
  • PP-T 3 4
  • PPT 3 4
  • Serine/Threonine-Protein Phosphatase 5 3

External Ids for PPP5C Gene

Previous Symbols for PPP5C Gene

  • PPP5

Summaries for PPP5C Gene

Entrez Gene Summary for PPP5C Gene

  • This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

GeneCards Summary for PPP5C Gene

PPP5C (Protein Phosphatase 5, Catalytic Subunit) is a Protein Coding gene. Diseases associated with PPP5C include breast cancer. Among its related pathways are MAPK signaling pathway and MAPK signaling pathway. GO annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is PPEF2.

UniProtKB/Swiss-Prot for PPP5C Gene

  • Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Gene Wiki entry for PPP5C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP5C Gene

Genomics for PPP5C Gene

Genomic Location for PPP5C Gene

Start:
46,346,994 bp from pter
End:
46,392,981 bp from pter
Size:
45,988 bases
Orientation:
Plus strand

Genomic View for PPP5C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP5C Gene

Regulatory Elements for PPP5C Gene

Proteins for PPP5C Gene

  • Protein details for PPP5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53041-PPP5_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 5
    Protein Accession:
    P53041
    Secondary Accessions:
    • Q16722
    • Q53XV2

    Protein attributes for PPP5C Gene

    Size:
    499 amino acids
    Molecular mass:
    56879 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 Mg(2+) or Mn(2+) cations per subunit.;
    Quaternary structure:
    • Part of a complex with HSP90/HSP90AA1 and steroid receptors. Interacts with CDC16, CDC27. Interacts with KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5. Interacts (via TPR repeats) with HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase activity. Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid. Interacts with ATM and ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity. Interacts with RAD17; reduced by DNA damage. Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist); regulates their transactivation activities. Interacts (via TPR repeats) with S100 proteins S100A1, S100A2, S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and compete with HSP90AA1 and MAP3K5 interactions. Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3 phosphorylation and protein levels. Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2 downregulates the phosphatase activity on CSNK1E. Interacts (via TPR repeats) with the active form of RAC1, GNA12 or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane.

    Three dimensional structures from OCA and Proteopedia for PPP5C Gene

neXtProt entry for PPP5C Gene

Proteomics data for PPP5C Gene at MOPED

Selected DME Specific Peptides for PPP5C Gene

Post-translational modifications for PPP5C Gene

  • Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32 and Lys412

Other Protein References for PPP5C Gene

Domains for PPP5C Gene

Gene Families for PPP5C Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • PPP :Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

UniProtKB/Swiss-Prot:

PPP5_HUMAN
Family:
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.:
    • P53041
Similarity:
  • Contains 3 TPR repeats.:
    • P53041
genes like me logo Genes that share domains with PPP5C: view

Function for PPP5C Gene

Molecular function for PPP5C Gene

GENATLAS Biochemistry: serine/threorine phosphatase 5,catalytic subunit,ubiquitously expressed,not involved as tumor suppressor gene in glioma
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.847 uM for CSNK1E (at 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549}; KM=13.2 uM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549};
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Enzyme Numbers (IUBMB) for PPP5C Gene

Gene Ontology (GO) - Molecular Function for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004721 phosphoprotein phosphatase activity ISS 9383998
GO:0004722 protein serine/threonine phosphatase activity TAS 7925273
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 11504734
genes like me logo Genes that share ontologies with PPP5C: view
genes like me logo Genes that share phenotypes with PPP5C: view

Animal Models for PPP5C Gene

MGI Knock Outs for PPP5C:

miRNA for PPP5C Gene

miRTarBase miRNAs that target PPP5C

No data available for Transcription Factor Targeting and HOMER Transcription for PPP5C Gene

Localization for PPP5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP5C Gene

Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP5C Gene COMPARTMENTS Subcellular localization image for PPP5C gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
cytoskeleton 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7925273
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP5C: view

Pathways for PPP5C Gene

genes like me logo Genes that share pathways with PPP5C: view

Pathways by source for PPP5C Gene

2 Cell Signaling Technology pathways for PPP5C Gene
1 KEGG pathway for PPP5C Gene

Gene Ontology (GO) - Biological Process for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated TAS 7925273
GO:0006470 protein dephosphorylation IEA --
GO:0007067 mitotic nuclear division TAS 7925273
GO:0007165 signal transduction IMP 12761501
genes like me logo Genes that share ontologies with PPP5C: view

Compounds for PPP5C Gene

(5) HMDB Compounds for PPP5C Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Iron
  • Armco iron
7439-89-6
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(9) Novoseek inferred chemical compound relationships for PPP5C Gene

Compound -log(P) Hits PubMed IDs
threonine 74.4 23
serine 64.1 23
p-nitrophenyl phosphate 60.3 1
okadaic acid 53.3 2
arachidonic acid 40.6 8
genes like me logo Genes that share compounds with PPP5C: view

Transcripts for PPP5C Gene

Unigene Clusters for PPP5C Gene

Protein phosphatase 5, catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP5C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: - - - -
SP12: -
SP13: - -

ExUns: 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP5C Gene

GeneLoc Exon Structure for
PPP5C
ECgene alternative splicing isoforms for
PPP5C

Expression for PPP5C Gene

mRNA expression in normal human tissues for PPP5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP5C Gene

SOURCE GeneReport for Unigene cluster for PPP5C Gene Hs.654604

mRNA Expression by UniProt/SwissProt for PPP5C Gene

P53041-PPP5_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with PPP5C: view

Orthologs for PPP5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP5C 36
  • 99.2 (n)
  • 99.8 (a)
PPP5C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP5C 36
  • 92.85 (n)
  • 97.39 (a)
PPP5C 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP5C 36
  • 91.65 (n)
  • 98.04 (a)
PPP5C 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp5c 36
  • 91.05 (n)
  • 97.8 (a)
Ppp5c 16
Ppp5c 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP5C 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP5C 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp5c 36
  • 90.71 (n)
  • 98 (a)
lizard
(Anolis carolinensis)
Reptilia PPP5C 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia PP5 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp5c 36
  • 69.98 (n)
  • 79.51 (a)
Str.1816 36
zebrafish
(Danio rerio)
Actinopterygii ppp5c 36
  • 76.27 (n)
  • 84.53 (a)
ppp5c 37
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004151 36
  • 63.6 (n)
  • 60.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta PpD3 36
  • 64.38 (n)
  • 63.17 (a)
PpD3 37
  • 58 (a)
OneToOne
PpD3 38
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea pph-5 36
  • 57.96 (n)
  • 60.39 (a)
pph-5 37
  • 57 (a)
OneToOne
Y39B6A.2 38
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR083C 36
  • 55.17 (n)
  • 44.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPT1 36
  • 47.67 (n)
  • 43.01 (a)
PPT1 37
  • 37 (a)
OneToMany
PPT1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10912g 36
  • 50.29 (n)
  • 45.04 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6044 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PP5.2 36
  • 57.63 (n)
  • 56.57 (a)
corn
(Zea mays)
Liliopsida Zm.15554 36
rice
(Oryza sativa)
Liliopsida Os.19558 36
Os05g0204900 36
  • 57.68 (n)
  • 56.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01433 36
  • 58.88 (n)
  • 51.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3F6.01c 36
  • 50.79 (n)
  • 50.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6199 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5196 37
  • 54 (a)
OneToOne
Species with no ortholog for PPP5C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP5C Gene

ENSEMBL:
Gene Tree for PPP5C (if available)
TreeFam:
Gene Tree for PPP5C (if available)

Paralogs for PPP5C Gene

Paralogs for PPP5C Gene

Selected SIMAP similar genes for PPP5C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPP5C: view

Variants for PPP5C Gene

Sequence variations from dbSNP and Humsavar for PPP5C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8811 -- 46,390,553(+) AGAGA(A/G)GAAGG utr-variant-3-prime
rs741231 -- 46,390,906(+) GCCTG(A/C)TCAGG utr-variant-3-prime
rs741237 -- 46,351,856(+) GCTGG(A/G)GCAGC intron-variant
rs759290 -- 46,388,854(+) CATGA(C/T)GAACA intron-variant
rs759291 -- 46,389,981(+) CAGCC(A/C)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP5C Gene

Variant ID Type Subtype PubMed ID
nsv912183 CNV Loss 21882294
nsv912184 CNV Gain 21882294
nsv912185 CNV Loss 21882294
esv2718654 CNV Deletion 23290073
nsv138470 CNV Loss 16902084

Relevant External Links for PPP5C Gene

HapMap Linkage Disequilibrium report
PPP5C

Disorders for PPP5C Gene

(1) MalaCards Diseases for PPP5C Gene

Search for PPP5C Gene in MalaCards »

(4) Novoseek inferred disease relationships for PPP5C Gene

Disease -log(P) Hits PubMed IDs
shock 25.3 3
alzheimers disease 7.95 3
tumors 0 8
cancer 0 5
genes like me logo Genes that share disorders with PPP5C: view

No data available for UniProtKB/Swiss-Prot for PPP5C Gene

Publications for PPP5C Gene

  1. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. (PMID: 7925273) Chen M.X. … Cohen P.T.W. (EMBO J. 1994) 3 4 23
  2. Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene. (PMID: 8561788) Xu X. … Zetterberg A. (Biochem. Biophys. Res. Commun. 1996) 3 4 23
  3. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. (PMID: 9195923) Silverstein A.M. … Pratt W.B. (J. Biol. Chem. 1997) 2 3 23
  4. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex. (PMID: 9405394) Ollendorff V. … Donoghue D.J. (J. Biol. Chem. 1997) 3 4 23
  5. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. (PMID: 9482716) Das A.K. … Barford D. (EMBO J. 1998) 3 4 23

Products for PPP5C Gene

Sources for PPP5C Gene

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