PPP5C Gene
protein-coding GIFtS: 64
GCID: GC19P046850
|
|
protein phosphatase 5, catalytic subunit
(Previous symbol: PPP5)
| |
Aliases
for PPP5C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Phosphatase 5, Catalytic Subunit1 2 | | PP-T2 3 | | PP51 2 3 5 | | PPT2 3 | | PPP51 2 3 | | EC 3.1.3.163 8 | | Protein Phosphatase T2 3 | | Serine/Threonine-Protein Phosphatase 52 |
Export aliases for PPP5C gene to outside databasesPrevious GC identifers: GC19P047494 GC19P047241 GC19P051526 GC19P051542 GC19P043278 |
Summaries
for PPP5C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPP5C:
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family.Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonineresidues; many of these pathways are involved in the regulation of cell growth and differentiation. The product ofthis gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevatedlevels of this protein may be associated with breast cancer development. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Feb 2011)
UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041Function: May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serineresidues of skeletal muscle phosphorylase and histone H1
Gene Wiki entry for PPP5C
|
Genomic Views
for PPP5C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPP5C gene promoter:
Spz1 SREBP-1a AP-1 ATF-2 p300 c-Jun SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPP5C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP5C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.3PPP5C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P046850: view genomic region
(about GC identifiers)
Start:
|
46,850,251 bp from pter |
End:
|
46,896,238 bp from pter |
Size:
|
45,988 bases |
Orientation:
|
plus strand |
|
Proteins
for PPP5C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041 (See
protein sequence)Recommended Name: Serine/threonine-protein phosphatase 5 Size: 499 amino acids; 56879 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: Interacts with CDC16 and CDC27
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm
6/13 PDB 3D structures from  and Proteopedia  for PPP5C (see all 13):1A17 (3D)
1S95 (3D)
1WAO (3D)
2BUG (3D)
3H60 (3D)
3H61 (3D)
Secondary accessions: Q16722 Q53XV2Explore the universe of human proteins at neXtProt for PPP5C: NX_P53041
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P53041
4/6 DME Specific Peptides for PPP5C (P53041) (see all 6)
PPP5C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191213.1 NP_006238.1
ENSEMBL proteins: ENSP00000012443 ENSP00000434329 ENSP00000375786
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
PPP5C for ontologies About GeneDecksing
PPP5C Antibody Products:
Assay Products for PPP5C: |
Protein
Domains /
Families
for PPP5C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPP5C for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P53041ProtoNet protein and cluster: P53041 1 Blocks protein family: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041Similarity: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamilySimilarity: Contains 3 TPR repeats |
Function
for PPP5C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041Function: May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serineresidues of skeletal muscle phosphorylase and histone H1Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate Genatlas biochemistry entry for PPP5C:serine/threorine phosphatase 5,catalytic subunit,ubiquitously expressed,not involved as tumor suppressor gene in glioma
Enzyme Number (IUBMB): EC 3.1.3.161 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP5C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP5C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PPP5C (NM_006247) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP5C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP5C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP5C |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
PPP5C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PPP5C:
Animal Models:
Mouse knock-outs for PPP5C: Ppp5ctm1Lex Ppp5ctm1.2Rhon
11 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Ppp5c):
PPP5C for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPP5C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MAPK signaling pathway | | | 2 | Cell Cycle / Checkpoint Control | | | 3 | Meiosis | | | 4 | ErbB1 downstream signaling | | | 5 | Glucocorticoid receptor regulatory network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PPP5C
2 
Cell Signaling Technology (CST) Pathways for PPP5C
3  BioSystems Pathways for PPP5C
1 
Kegg Pathway (Kegg details for PPP5C):
PPP5C for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP5C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/69 Interacting proteins for PPP5C (P530411, 2, 3 ENSP000000124434) via UniProtKB, MINT, STRING, and/or I2D (see all 69)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
PPP5C for ontologies About GeneDecksing
|
Drugs & Compounds
for PPP5C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PPP5C for compounds About GeneDecksing
 Browse Tocris compounds for PPP5C
5 HMDB Compounds for PPP5C About this table
9 Novoseek chemical compound relationships for PPP5C gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
74.4 |
27 |
11389770 (2), 15374638 (2), 18253812 (2), 12519780 (1) (see all 20) |
| serine |
64.1 |
27 |
7925273 (2), 11389770 (2), 15374638 (2), 18253812 (2) (see all 19) |
| p-nitrophenyl phosphate |
60.3 |
1 |
15890660 (1) |
| okadaic acid |
53.3 |
3 |
7925273 (1), 15890660 (1) |
| arachidonic acid |
40.6 |
8 |
19404779 (2), 15577939 (2), 14690518 (1), 9000529 (1) (see all 6) |
| rapamycin |
27 |
8 |
15218033 (5), 18280813 (1) |
| tacrolimus |
12.3 |
6 |
9195923 (4) |
| lipid |
0 |
2 |
10471836 (1), 18547097 (1) |
| fatty acid |
0 |
2 |
11969423 (1), 11523989 (1) |
Search CenterWatch for drugs/clinical trials and news about PPP5C / PPP5
|
Transcripts
for PPP5C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPP5C gene (2 alternative transcripts): NM_001204284.1 NM_006247.3 Unigene Cluster for PPP5C: Protein phosphatase 5, catalytic subunit Hs.654604 [show with all ESTs]Unigene Representative Sequence: AB20961514 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000012443(uc002pem.3 uc002pen.3 uc010xya.2) ENST00000478046
ENST00000391919 ENST00000467902 ENST00000527193 ENST00000487483(uc010xyb.1)
ENST00000532058 ENST00000486994 ENST00000467502 ENST00000493347 ENST00000491003
ENST00000492109 ENST00000525507 ENST00000527623
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP5C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP5C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PPP5C (NM_006247) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP5C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP5C |
Additional cDNA sequence: AB209615.1 AK094241.1 AK223222.1 AK293402.1 AK293475.1 AK297095.1 AK312683.1 BC000750.2 BC001831.2 BC001970.1 BT007275.1 U25174.1 X89416.1 X92121.1 18 DOTS entries: DT.102828793 DT.446391 DT.97854807 DT.95263432 DT.121505135 DT.97767914 DT.121505084 DT.95263436 DT.100884187 DT.100884175 DT.100884183 DT.121505106 DT.121505088 DT.40271984 DT.92449140 DT.100884172 DT.100884185 DT.92449137 24/484 AceView cDNA sequences (see all 484): BQ654021 BU186314 AW162027 M78859 BQ086290 BQ012794 BM129394 BG762007 BE294823 BU160966 BQ771534 BE249858 X89416 BG769002 BF844758 BQ645356 BG679721 AL557401 AI800562 BF221783 CF132366 BQ102376 BU845520 BM703840
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PPP5C (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | - | | | | | | | |
| ExUns: | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PPP5C
|
Expression
for PPP5C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPP5C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGGCTAG
About this image
See PPP5C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP5C
SOURCE GeneReport for Unigene cluster: Hs.654604
UniProtKB/Swiss-Prot: PPP5_HUMAN, P53041Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including PPP5C:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP5C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP5C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP5C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP5C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP5C |
Orthologs
for PPP5C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPP5C gene from 8/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PPP5C6 |
-- |
90(a) |
1 ↔ 1 |
GL343568.1(252490-279880) |
African clawed frog
(Xenopus laevis) |
Amphibia |
PP52 |
protein phosphatase 5 |
74.14(n) |
|
AF018263.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1108011 |
zgc:110801 |
76.27(n)
84.53(a) |
|
541536 NM_001014350.2 NP_001014372.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
PpD31 , 3 |
protein amino acid dephosphorylation protein
serine/threonine more3
Protein phosphatase D31 |
63(a)3
64.38(n)1
63.17(a)1 |
|
85E63
497791 NM_080207.21 NP_524946.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y39B6A.23
pph-51 |
Protein PPH-51 |
55(a)3
57.75(n)1
59.58(a)1 |
|
V(19187234-19195602)3
1802631 NM_171607.31 NP_741697.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
PPT1(YGR123C)4
PPT11 |
Protein serine/threonine phosphatase with similarity more4
Ppt1p1 |
48.1(n)1
44.52(a)1 |
|
7(738203-736662)4
8530231, 4 NP_011639.31 NP_011639.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PP5.21 |
serine/threonine-protein phosphatase 5 |
57.63(n)
56.57(a) |
|
818881 NM_129842.3 NP_565985.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.195582 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
77.67(n) |
|
AK102966.1 |
ENSEMBL Gene Tree for PPP5C (if available)
TreeFam Gene Tree for PPP5C (if available) |
Paralogs
for PPP5C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPP5C gene
- PPEF22 PPEF12
13 SIMAP similar genes for PPP5C using alignment to 4 protein entries: PPP5_HUMAN (see all proteins):PPP5D1 PPP2CA PPP2CB PPP4C PPP6C PPP1CC
PPP1CA PPP1CB PPP3CC PPP3CB PPP3CA SGTB
PPEF1
PPP5C for paralogs About GeneDecksing
|
Genomic Variants
for PPP5C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPP5C (46850251 - 46896238 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPP5C: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP5C |
|
Disorders
/ Diseases
for PPP5C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPP5C for disorders About GeneDecksing
OMIM gene information: 600658
OMIM disorders: --
9  diseases for PPP5C: About MalaCardsbreast cancer retinal degeneration alzheimer's disease retinitis
breast carcinoma hypoxia schizophrenia carcinoma
malaria
4 Novoseek disease relationships for PPP5C gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
25.3 |
4 |
11969423 (1), 15967796 (1), 11523989 (1) |
| alzheimers disease |
7.95 |
3 |
19404779 (1), 15546861 (1), 14690518 (1) |
| tumors |
0 |
16 |
15374638 (4), 18280813 (2), 11240142 (1), 9575175 (1) |
| cancer |
0 |
8 |
18280813 (1), 10413457 (1), 15374638 (1), 18253812 (1) (see all 5) |
Export disorders for PPP5C gene to outside databases
|
Publications
for PPP5C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPP5C gene, integrated from 9 sources (see all 113):
(articles sorted by number of sources associating them with PPP5C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3. (PubMed id 8666404)1, 2, 3 Yong W.H.... Louis D.N. (1995)
- The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex. (PubMed id 9405394)1, 2, 9 Ollendorff V. and Donoghue D.J. (1997)
- A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. (PubMed id 7925273)1, 2, 9 Chen M.X....Cohen P.T.W. (1994)
- Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene. (PubMed id 8561788)1, 2, 9 Xu X....Zetterberg A. (1996)
- The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. (PubMed id 9482716)1, 2, 9 Das A.K.... Barford D. (1998)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. (PubMed id 18280813)1, 9 Golden T....Honkanen R.E. (2008)
- Activated Rac1 GTPase translocates protein phosphatas e 5 to the cell membrane and stimulates phosphatase activity in vitro. (PubMed id 19948726)1, 9 Chatterjee A....Rossie S. (2010)
- Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. (PubMed id 9195923)1, 9 Silverstein A.M....Pratt W.B. (1997)
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External Searches for PPP5C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PPP5C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PPP5C gene
(According to HUGE)
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Specialized Databases showing PPP5C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for PPP5C gene:
Search GeneIP for patents involving PPP5C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PPP5C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for PPP5C | | OriGene shRNA RFP for PPP5C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP5C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP5C | | | OriGene Protein Over-expression Lysate for PPP5C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPP5C | | OriGene 3'-UTR Clone for PPP5C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP5C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP5C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for PPP5C |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP5C |
|  |  |  | | | | ThermoFisher Antibodies for PPP5C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP5C |
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