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Aliases for PPP5C Gene

Aliases for PPP5C Gene

  • Protein Phosphatase 5 Catalytic Subunit 2 3
  • Protein Phosphatase 5, Catalytic Subunit 2 3 5
  • Protein Phosphatase T 3 4
  • EC 3.1.3.16 4 63
  • PPP5 3 4
  • PP-T 3 4
  • PP5 3 4
  • PPT 3 4

External Ids for PPP5C Gene

Previous HGNC Symbols for PPP5C Gene

  • PPP5

Previous GeneCards Identifiers for PPP5C Gene

  • GC19P047494
  • GC19P047241
  • GC19P051526
  • GC19P051542
  • GC19P046850
  • GC19P043278

Summaries for PPP5C Gene

Entrez Gene Summary for PPP5C Gene

  • This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

GeneCards Summary for PPP5C Gene

PPP5C (Protein Phosphatase 5 Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is PPEF2.

UniProtKB/Swiss-Prot for PPP5C Gene

  • Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Gene Wiki entry for PPP5C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP5C Gene

Genomics for PPP5C Gene

Regulatory Elements for PPP5C Gene

Promoters for PPP5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP5C on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP5C Gene

Chromosome:
19
Start:
46,346,994 bp from pter
End:
46,392,981 bp from pter
Size:
45,988 bases
Orientation:
Plus strand

Genomic View for PPP5C Gene

Genes around PPP5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP5C Gene

Proteins for PPP5C Gene

  • Protein details for PPP5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53041-PPP5_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 5
    Protein Accession:
    P53041
    Secondary Accessions:
    • Q16722
    • Q53XV2

    Protein attributes for PPP5C Gene

    Size:
    499 amino acids
    Molecular mass:
    56879 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with CPNE1 (via VWFA domain) (By similarity). Part of a complex with HSP90/HSP90AA1 and steroid receptors. Interacts with CDC16, CDC27. Interacts with KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5. Interacts (via TPR repeats) with HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase activity. Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid. Interacts with ATM and ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity. Interacts with RAD17; reduced by DNA damage. Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist); regulates their transactivation activities. Interacts (via TPR repeats) with S100 proteins S100A1, S100A2, S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and compete with HSP90AA1 and MAP3K5 interactions. Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3 phosphorylation and protein levels. Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2 downregulates the phosphatase activity on CSNK1E. Interacts (via TPR repeats) with the active form of RAC1, GNA12 or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane.

    Three dimensional structures from OCA and Proteopedia for PPP5C Gene

neXtProt entry for PPP5C Gene

Proteomics data for PPP5C Gene at MOPED

Selected DME Specific Peptides for PPP5C Gene

Post-translational modifications for PPP5C Gene

  • Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.
  • Ubiquitination at Lys 32 and Lys 412
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP5C Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP5C (PPP5C)

Domains & Families for PPP5C Gene

Graphical View of Domain Structure for InterPro Entry

P53041

UniProtKB/Swiss-Prot:

PPP5_HUMAN :
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with PPP5C: view

Function for PPP5C Gene

Molecular function for PPP5C Gene

GENATLAS Biochemistry:
serine/threorine phosphatase 5,catalytic subunit,ubiquitously expressed,not involved as tumor suppressor gene in glioma
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.847 uM for CSNK1E (at 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549}; KM=13.2 uM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549};
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Enzyme Numbers (IUBMB) for PPP5C Gene

Gene Ontology (GO) - Molecular Function for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IEA,IPI 9383998
GO:0016787 hydrolase activity IEA --
GO:0043531 ADP binding IDA 23184943
genes like me logo Genes that share ontologies with PPP5C: view
genes like me logo Genes that share phenotypes with PPP5C: view

Animal Models for PPP5C Gene

MGI Knock Outs for PPP5C:

Animal Model Products

CRISPR Products

miRNA for PPP5C Gene

miRTarBase miRNAs that target PPP5C

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP5C Gene

Localization for PPP5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP5C Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). {ECO:0000269 PubMed:15383005, ECO:0000269 PubMed:19948726}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP5C Gene COMPARTMENTS Subcellular localization image for PPP5C gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with PPP5C: view

Pathways & Interactions for PPP5C Gene

SuperPathways for PPP5C Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 DNA Double-Strand Break Repair
genes like me logo Genes that share pathways with PPP5C: view

Pathways by source for PPP5C Gene

SIGNOR curated interactions for PPP5C Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006281 DNA repair IEA,TAS --
GO:0006351 transcription, DNA-templated TAS 7925273
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PPP5C: view

Drugs & Compounds for PPP5C Gene

(8) Drugs for PPP5C Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
calcium Nutra 0

(7) Additional Compounds for PPP5C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PPP5C: view

Transcripts for PPP5C Gene

Unigene Clusters for PPP5C Gene

Protein phosphatase 5, catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP5C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: - - - -
SP12: -
SP13: - -

ExUns: 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP5C Gene

GeneLoc Exon Structure for
PPP5C
ECgene alternative splicing isoforms for
PPP5C

Expression for PPP5C Gene

mRNA expression in normal human tissues for PPP5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP5C Gene

This gene is overexpressed in Lymph node (8.5) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP5C Gene



SOURCE GeneReport for Unigene cluster for PPP5C Gene Hs.654604

mRNA Expression by UniProt/SwissProt for PPP5C Gene

P53041-PPP5_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PPP5C: view

Protein tissue co-expression partners for PPP5C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP5C Gene

Orthologs for PPP5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP5C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP5C 35
  • 92.85 (n)
  • 97.39 (a)
PPP5C 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP5C 35
  • 91.65 (n)
  • 98.04 (a)
PPP5C 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp5c 35
  • 91.05 (n)
  • 97.8 (a)
Ppp5c 16
Ppp5c 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP5C 35
  • 99.2 (n)
  • 99.8 (a)
PPP5C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp5c 35
  • 90.71 (n)
  • 98 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP5C 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP5C 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP5C 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp5c 35
  • 69.98 (n)
  • 79.51 (a)
Str.1816 35
African clawed frog
(Xenopus laevis)
Amphibia PP5 35
zebrafish
(Danio rerio)
Actinopterygii ppp5c 35
  • 76.27 (n)
  • 84.53 (a)
ppp5c 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta PpD3 37
  • 63 (a)
PpD3 35
  • 64.38 (n)
  • 63.17 (a)
PpD3 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004151 35
  • 63.6 (n)
  • 60.81 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39B6A.2 37
  • 55 (a)
pph-5 35
  • 57.96 (n)
  • 60.39 (a)
pph-5 36
  • 57 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR083C 35
  • 55.17 (n)
  • 44.75 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10912g 35
  • 50.29 (n)
  • 45.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPT1 35
  • 47.67 (n)
  • 43.01 (a)
PPT1 36
  • 37 (a)
OneToMany
PPT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PP5.2 35
  • 57.63 (n)
  • 56.57 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6044 35
rice
(Oryza sativa)
Liliopsida Os.19558 35
Os05g0204900 35
  • 57.68 (n)
  • 56.9 (a)
corn
(Zea mays)
Liliopsida Zm.15554 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6199 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01433 35
  • 58.88 (n)
  • 51.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3F6.01c 35
  • 50.79 (n)
  • 50.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5196 36
  • 54 (a)
OneToOne
Species with no ortholog for PPP5C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP5C Gene

ENSEMBL:
Gene Tree for PPP5C (if available)
TreeFam:
Gene Tree for PPP5C (if available)

Paralogs for PPP5C Gene

Paralogs for PPP5C Gene

(14) SIMAP similar genes for PPP5C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPP5C: view

Variants for PPP5C Gene

Sequence variations from dbSNP and Humsavar for PPP5C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs741237 -- 46,351,856(+) GCTGG(A/G)GCAGC intron-variant
rs759301 -- 46,351,675(+) TCCTC(A/G)AAGGC intron-variant
rs759302 -- 46,351,721(+) TGCCC(A/G)GTTCT intron-variant
rs2009569 -- 46,366,374(-) agtaa(A/G)attct intron-variant
rs1124459 -- 46,350,532(+) GAGAA(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP5C Gene

Variant ID Type Subtype PubMed ID
nsv912183 CNV Loss 21882294
nsv912184 CNV Gain 21882294
nsv912185 CNV Loss 21882294
esv2718654 CNV Deletion 23290073
nsv138470 CNV Loss 16902084

Variation tolerance for PPP5C Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP5C Gene

HapMap Linkage Disequilibrium report
PPP5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP5C Gene

Disorders for PPP5C Gene

Relevant External Links for PPP5C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP5C

No disorders were found for PPP5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP5C Gene

Publications for PPP5C Gene

  1. Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3. (PMID: 8666404) Yong W.H. … Louis D.N. (Genomics 1995) 2 3 4 67
  2. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. (PMID: 9195923) Silverstein A.M. … Pratt W.B. (J. Biol. Chem. 1997) 2 3 23
  3. Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. (PMID: 19948726) Chatterjee A. … Rossie S. (J. Biol. Chem. 2010) 3 23
  4. Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation. (PMID: 19586900) Zhang Y. … Goleva E. (J. Biol. Chem. 2009) 3 23
  5. Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. (PMID: 18280813) Golden T. … Honkanen R.E. (Biochim. Biophys. Acta 2008) 3 23

Products for PPP5C Gene

Sources for PPP5C Gene

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