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Aliases for PPP4R3B Gene

Aliases for PPP4R3B Gene

  • Protein Phosphatase 4 Regulatory Subunit 3B 2 3 5
  • PP4R3B 3 4
  • SMEK2 3 4
  • Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 3B 3
  • SMEK Homolog 2, Suppressor Of Mek1 (Dictyostelium) 2
  • Protein Phosphatase 4, Regulatory Subunit 3B 2
  • SMEK Homolog 2, Suppressor Of Mek1 3
  • SMEK Homolog 2 4
  • KIAA1387 4
  • FLFL2 3
  • Smk1 3
  • PSY2 3

External Ids for PPP4R3B Gene

Previous HGNC Symbols for PPP4R3B Gene

  • SMEK2

Summaries for PPP4R3B Gene

GeneCards Summary for PPP4R3B Gene

PPP4R3B (Protein Phosphatase 4 Regulatory Subunit 3B) is a Protein Coding gene. Diseases associated with PPP4R3B include Mixed Germ Cell Cancer. Among its related pathways are Integrated Breast Cancer Pathway and Glucagon signaling pathway. An important paralog of this gene is PPP4R3A.

UniProtKB/Swiss-Prot for PPP4R3B Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.

Gene Wiki entry for PPP4R3B Gene

Additional gene information for PPP4R3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R3B Gene

Genomics for PPP4R3B Gene

GeneHancer (GH) Regulatory Elements for PPP4R3B Gene

Promoters and enhancers for PPP4R3B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I055614 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557.9 +1.5 1543 5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ENSG00000272606 PPP4R3B GC02P055618 RPS27A PNPT1 PRORSD1P CLHC1 GC02P055601
GH02I055838 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.3 -220.6 -220604 2.3 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ETS1 YY1 SP5 REST PPARG EFEMP1 ENSG00000240401 PPP4R3B GC02P055762
GH02I055585 Enhancer 0.5 Ensembl 8.2 +33.0 32979 1 JUND JUN CEBPB EP300 ENSG00000212175 ENSG00000272606 PPP4R3B GC02P055601
GH02I055712 Enhancer 0.4 ENCODE 7.6 -95.3 -95338 4.1 ZNF24 ZNF644 ATF2 PNPT1 MIR217 PPP4R3B CLHC1 EFEMP1 ENSG00000272606 GC02P055700 GC02P055762
GH02I054770 Enhancer 0.6 ENCODE 4.1 +846.7 846702 2.7 FOSL1 JUND ZNF316 JUN MAFG RCOR1 FOS MAFK CHD2 EML6 LOC105374667 SPTBN1 PPP4R3B GC02P054774
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP4R3B on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPP4R3B Gene

Genomic Locations for PPP4R3B Gene
71,589 bases
Minus strand

Genomic View for PPP4R3B Gene

Genes around PPP4R3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP4R3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP4R3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R3B Gene

Proteins for PPP4R3B Gene

  • Protein details for PPP4R3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3B
    Protein Accession:
    Secondary Accessions:
    • Q6P9B0
    • Q86XB8
    • Q9BQJ0
    • Q9BRK2
    • Q9H913
    • Q9P2G0

    Protein attributes for PPP4R3B Gene

    849 amino acids
    Molecular mass:
    97458 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3B.
    • Sequence=BAA92625.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R3B Gene


neXtProt entry for PPP4R3B Gene

Post-translational modifications for PPP4R3B Gene

No Post-translational modifications

No data available for DME Specific Peptides for PPP4R3B Gene

Domains & Families for PPP4R3B Gene

Gene Families for PPP4R3B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PPP4R3B Gene

Suggested Antigen Peptide Sequences for PPP4R3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMEK family.
  • Belongs to the SMEK family.
genes like me logo Genes that share domains with PPP4R3B: view

Function for PPP4R3B Gene

Molecular function for PPP4R3B Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.

Phenotypes From GWAS Catalog for PPP4R3B Gene

Phenotypes for PPP4R3B Gene

GenomeRNAi human phenotypes for PPP4R3B:
genes like me logo Genes that share phenotypes with PPP4R3B: view

miRNA for PPP4R3B Gene

miRTarBase miRNAs that target PPP4R3B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP4R3B Gene

Localization for PPP4R3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP4R3B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP4R3B gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP4R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PPP4R3B: view

Pathways & Interactions for PPP4R3B Gene

genes like me logo Genes that share pathways with PPP4R3B: view

Pathways by source for PPP4R3B Gene

1 BioSystems pathway for PPP4R3B Gene
1 KEGG pathway for PPP4R3B Gene

Interacting Proteins for PPP4R3B Gene

Selected Interacting proteins: Q5MIZ7-P4R3B_HUMAN for PPP4R3B Gene via IID

Gene Ontology (GO) - Biological Process for PPP4R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0019216 regulation of lipid metabolic process IEA --
GO:0045722 positive regulation of gluconeogenesis IEA --
genes like me logo Genes that share ontologies with PPP4R3B: view

No data available for SIGNOR curated interactions for PPP4R3B Gene

Drugs & Compounds for PPP4R3B Gene

No Compound Related Data Available

Transcripts for PPP4R3B Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R3B Gene

No ASD Table

Relevant External Links for PPP4R3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP4R3B Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP4R3B Gene:


mRNA Expression by UniProt/SwissProt for PPP4R3B Gene:

Tissue specificity: Moderately expressed in tissues and specific brain regions examined.

Evidence on tissue expression from TISSUES for PPP4R3B Gene

  • Nervous system(4.8)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP4R3B Gene

Orthologs for PPP4R3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP4R3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMEK2 33
  • 99.73 (n)
(Canis familiaris)
Mammalia SMEK2 33
  • 95.72 (n)
(Bos Taurus)
Mammalia SMEK2 33
  • 94.24 (n)
(Rattus norvegicus)
Mammalia Smek2 33
  • 93.88 (n)
(Mus musculus)
Mammalia Smek2 33
  • 93.15 (n)
Ppp4r3b 16
(Gallus gallus)
Aves SMEK2 33
  • 85.21 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia smek2 33
  • 82.29 (n)
Str.10217 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53159 33
(Danio rerio)
Actinopterygii smek2 33
  • 67.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta flfl 33
  • 59.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003402 33
  • 59.04 (n)
(Oryza sativa)
Liliopsida Os.16549 33
Species where no ortholog for PPP4R3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP4R3B Gene

Gene Tree for PPP4R3B (if available)
Gene Tree for PPP4R3B (if available)

Paralogs for PPP4R3B Gene

Paralogs for PPP4R3B Gene Pseudogenes for PPP4R3B Gene

genes like me logo Genes that share paralogs with PPP4R3B: view

Variants for PPP4R3B Gene

Sequence variations from dbSNP and Humsavar for PPP4R3B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000011209 -- 55,564,322(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000021861 -- 55,581,949(-) A/G intron_variant
rs1000042525 -- 55,616,229(-) G/A intron_variant
rs1000105937 -- 55,570,224(-) T/C intron_variant
rs1000119507 -- 55,601,539(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4R3B Gene

Variant ID Type Subtype PubMed ID
esv2759050 CNV gain 17122850
esv3575244 CNV gain 25503493
nsv1160801 CNV duplication 26073780
nsv520581 CNV loss 19592680
nsv525434 CNV loss 19592680
nsv829430 CNV loss 20364138
nsv834080 CNV loss 17160897

Variation tolerance for PPP4R3B Gene

Residual Variation Intolerance Score: 3.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP4R3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R3B Gene

Disorders for PPP4R3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP4R3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PPP4R3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP4R3B Gene

Publications for PPP4R3B Gene

  1. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. (PMID: 18614045) Chowdhury D … Lieberman J (Molecular cell 2008) 2 3 4 58
  2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras AC … Aebersold R (Molecular & cellular proteomics : MCP 2005) 2 3 4 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PPP4R3B Gene

Sources for PPP4R3B Gene

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