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Aliases for PPP4R3B Gene

Aliases for PPP4R3B Gene

  • Protein Phosphatase 4 Regulatory Subunit 3B 2 3 5
  • Protein Phosphatase 4, Regulatory Subunit 3B 2 3
  • PP4R3B 3 4
  • SMEK2 3 4
  • SMEK Homolog 2, Suppressor Of Mek1 (Dictyostelium) 2
  • SMEK Homolog 2, Suppressor Of Mek1 3
  • SMEK Homolog 2 4
  • KIAA1387 4
  • FLFL2 3
  • Smk1 3
  • PSY2 3

External Ids for PPP4R3B Gene

Previous HGNC Symbols for PPP4R3B Gene

  • SMEK2

Summaries for PPP4R3B Gene

GeneCards Summary for PPP4R3B Gene

PPP4R3B (Protein Phosphatase 4 Regulatory Subunit 3B) is a Protein Coding gene. Diseases associated with PPP4R3B include Mixed Germ Cell Cancer. Among its related pathways are Glucagon signaling pathway and Integrated Breast Cancer Pathway. An important paralog of this gene is PPP4R3A.

UniProtKB/Swiss-Prot for PPP4R3B Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.

Gene Wiki entry for PPP4R3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R3B Gene

Genomics for PPP4R3B Gene

Regulatory Elements for PPP4R3B Gene

Enhancers for PPP4R3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP4R3B on UCSC Golden Path with GeneCards custom track

Promoters for PPP4R3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP4R3B on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP4R3B Gene

55,547,292 bp from pter
55,618,880 bp from pter
71,589 bases
Minus strand

Genomic View for PPP4R3B Gene

Genes around PPP4R3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP4R3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP4R3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R3B Gene

Proteins for PPP4R3B Gene

  • Protein details for PPP4R3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3B
    Protein Accession:
    Secondary Accessions:
    • Q6P9B0
    • Q86XB8
    • Q9BQJ0
    • Q9BRK2
    • Q9H913
    • Q9P2G0

    Protein attributes for PPP4R3B Gene

    849 amino acids
    Molecular mass:
    97458 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3B.
    • Sequence=BAA92625.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R3B Gene


neXtProt entry for PPP4R3B Gene

Proteomics data for PPP4R3B Gene at MOPED

Post-translational modifications for PPP4R3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP4R3B Gene

No data available for DME Specific Peptides for PPP4R3B Gene

Domains & Families for PPP4R3B Gene

Protein Domains for PPP4R3B Gene


Suggested Antigen Peptide Sequences for PPP4R3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 WH1 domain.
  • Belongs to the SMEK family.
  • Contains 1 WH1 domain.
  • Belongs to the SMEK family.
genes like me logo Genes that share domains with PPP4R3B: view

No data available for Gene Families for PPP4R3B Gene

Function for PPP4R3B Gene

Molecular function for PPP4R3B Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.

Phenotypes for PPP4R3B Gene

GenomeRNAi human phenotypes for PPP4R3B:
genes like me logo Genes that share phenotypes with PPP4R3B: view

Animal Model Products

miRNA for PPP4R3B Gene

miRTarBase miRNAs that target PPP4R3B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP4R3B Gene

Localization for PPP4R3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP4R3B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions.

Gene Ontology (GO) - Cellular Components for PPP4R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030289 protein phosphatase 4 complex IEA --
genes like me logo Genes that share ontologies with PPP4R3B: view

No data available for Subcellular locations from COMPARTMENTS for PPP4R3B Gene

Pathways & Interactions for PPP4R3B Gene

genes like me logo Genes that share pathways with PPP4R3B: view

Pathways by source for PPP4R3B Gene

1 BioSystems pathway for PPP4R3B Gene
1 KEGG pathway for PPP4R3B Gene

Interacting Proteins for PPP4R3B Gene

Gene Ontology (GO) - Biological Process for PPP4R3B Gene


No data available for SIGNOR curated interactions for PPP4R3B Gene

Drugs & Compounds for PPP4R3B Gene

No Compound Related Data Available

Transcripts for PPP4R3B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R3B Gene

No ASD Table

Relevant External Links for PPP4R3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP4R3B Gene

mRNA Expression by UniProt/SwissProt for PPP4R3B Gene

Tissue specificity: Moderately expressed in tissues and specific brain regions examined.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PPP4R3B Gene

Orthologs for PPP4R3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP4R3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMEK2 35
  • 94.24 (n)
  • 96.99 (a)
(Canis familiaris)
Mammalia SMEK2 35
  • 95.72 (n)
  • 98.64 (a)
(Mus musculus)
Mammalia Smek2 35
  • 93.15 (n)
  • 96.7 (a)
Smek2 16
(Pan troglodytes)
Mammalia SMEK2 35
  • 99.73 (n)
  • 99.41 (a)
(Rattus norvegicus)
Mammalia Smek2 35
  • 93.88 (n)
  • 97.8 (a)
(Gallus gallus)
Aves SMEK2 35
  • 85.21 (n)
  • 94.73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smek2 35
  • 82.29 (n)
  • 93.02 (a)
Str.10217 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53159 35
(Danio rerio)
Actinopterygii smek2 35
  • 67.65 (n)
  • 77.25 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003402 35
  • 59.04 (n)
  • 61.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta flfl 35
  • 59.95 (n)
  • 61.09 (a)
(Oryza sativa)
Liliopsida Os.16549 35
Species with no ortholog for PPP4R3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP4R3B Gene

Gene Tree for PPP4R3B (if available)
Gene Tree for PPP4R3B (if available)

Paralogs for PPP4R3B Gene

Paralogs for PPP4R3B Gene

genes like me logo Genes that share paralogs with PPP4R3B: view

Variants for PPP4R3B Gene

Sequence variations from dbSNP and Humsavar for PPP4R3B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34999684 - 55,598,460(-) TTACG(A/T)CTTTT intron-variant, reference, missense
rs2903704 - 55,578,304(+) ACATA(C/T)GAAAC intron-variant, reference, missense
rs736345 -- 55,619,011(+) ACACT(A/G)CAACG upstream-variant-2KB
rs744514 -- 55,619,377(-) TCTAG(A/T)ATTCC upstream-variant-2KB
rs782586 -- 55,609,029(-) CTGCT(G/T)CTGGC intron-variant

Variation tolerance for PPP4R3B Gene

Residual Variation Intolerance Score: 3.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PPP4R3B Gene

Disorders for PPP4R3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP4R3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP4R3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPP4R3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP4R3B Gene

Publications for PPP4R3B Gene

  1. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. (PMID: 18614045) Chowdhury D. … Lieberman J. (Mol. Cell 2008) 2 3 4 67
  2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras A.-C. … Aebersold R. (Mol. Cell. Proteomics 2005) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PPP4R3B Gene

Sources for PPP4R3B Gene