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Aliases for PPP4R3A Gene

Aliases for PPP4R3A Gene

  • Protein Phosphatase 4 Regulatory Subunit 3A 2 3 5
  • KIAA2010 2 3 4
  • PP4R3A 3 4
  • SMEK1 3 4
  • Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 3A 3
  • SMEK Homolog 1, Suppressor Of Mek1 (Dictyostelium) 2
  • Protein Phosphatase 4, Regulatory Subunit 3A 2
  • SMEK Homolog 1, Suppressor Of Mek1 3
  • SMEK Homolog 1 4
  • MSTP033 3
  • FLFL1 3
  • PP4R3 3
  • Smk-1 3
  • Smk1 3

External Ids for PPP4R3A Gene

Previous HGNC Symbols for PPP4R3A Gene

  • KIAA2010
  • SMEK1

Summaries for PPP4R3A Gene

GeneCards Summary for PPP4R3A Gene

PPP4R3A (Protein Phosphatase 4 Regulatory Subunit 3A) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Glucagon signaling pathway. An important paralog of this gene is PPP4R3B.

UniProtKB/Swiss-Prot for PPP4R3A Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R3A Gene

Genomics for PPP4R3A Gene

Regulatory Elements for PPP4R3A Gene

Enhancers for PPP4R3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F091360 1.6 FANTOM5 Ensembl ENCODE 11.9 +138.5 138471 23.8 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF548 TRIP11 CCDC88C RPS18P2 CPSF2 PPP4R3A ENSG00000258875 ENSG00000260711 RPS6KA5 GC14M091384 PIR43651
GH14F091420 0.2 Ensembl 10.9 +89.3 89254 1.0 NR2F1 MAFG CEBPB ZNF384 CEBPG TEAD3 ZNF316 GATA3 MAFF CEBPA PPP4R3A ENSG00000258446
GH14F091581 0.7 ENCODE 10 -70.9 -70878 0.2 MAFK PPP4R3A PIR56014 GC14M091603
GH14F091817 0.2 ENCODE 9.8 -307.5 -307511 0.3 CBX5 IKZF1 NBN TRIM22 EBF1 TBX21 RELA TC2N CATSPERB FBLN5 PPP4R3A GC14M091803
GH14F091896 1.2 Ensembl ENCODE 9.5 -387.1 -387132 2.3 PKNOX1 FEZF1 CEBPG ZSCAN9 ZIC2 RAD21 YY1 ZFHX2 ZNF600 HLF FBLN5 TC2N PPP4R3A GC14M091884
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPP4R3A on UCSC Golden Path with GeneCards custom track

Promoters for PPP4R3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241567 1154 4401 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for PPP4R3A Gene

Chromosome:
14
Start:
91,457,481 bp from pter
End:
91,510,554 bp from pter
Size:
53,074 bases
Orientation:
Minus strand

Genomic View for PPP4R3A Gene

Genes around PPP4R3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP4R3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP4R3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R3A Gene

Proteins for PPP4R3A Gene

  • Protein details for PPP4R3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IN85-P4R3A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Protein Accession:
    Q6IN85
    Secondary Accessions:
    • Q69YK6
    • Q86U23
    • Q86YI7
    • Q8IVG1
    • Q9H3F1
    • Q9H7U8
    • Q9NV01
    • Q9NWP1

    Protein attributes for PPP4R3A Gene

    Size:
    833 amino acids
    Molecular mass:
    95368 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.
    SequenceCaution:
    • Sequence=AAG39284.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAA91960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91960.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence={ECO:0000305}; Sequence=BAB14877.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC23106.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP4R3A Gene

Post-translational modifications for PPP4R3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP4R3A Gene

Domains & Families for PPP4R3A Gene

Protein Domains for PPP4R3A Gene

Suggested Antigen Peptide Sequences for PPP4R3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IN85

UniProtKB/Swiss-Prot:

P4R3A_HUMAN :
  • Contains 1 WH1 domain.
  • Belongs to the SMEK family.
Domain:
  • Contains 1 WH1 domain.
Family:
  • Belongs to the SMEK family.
genes like me logo Genes that share domains with PPP4R3A: view

No data available for Gene Families for PPP4R3A Gene

Function for PPP4R3A Gene

Molecular function for PPP4R3A Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
genes like me logo Genes that share phenotypes with PPP4R3A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP4R3A Gene

Localization for PPP4R3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP4R3A Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.

Gene Ontology (GO) - Cellular Components for PPP4R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PPP4R3A: view

No data available for Subcellular locations from COMPARTMENTS for PPP4R3A Gene

Pathways & Interactions for PPP4R3A Gene

genes like me logo Genes that share pathways with PPP4R3A: view

Pathways by source for PPP4R3A Gene

1 BioSystems pathway for PPP4R3A Gene
1 KEGG pathway for PPP4R3A Gene

Interacting Proteins for PPP4R3A Gene

SIGNOR curated interactions for PPP4R3A Gene

Activates:

Gene Ontology (GO) - Biological Process for PPP4R3A Gene

None

Transcripts for PPP4R3A Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R3A Gene

No ASD Table

Relevant External Links for PPP4R3A Gene

GeneLoc Exon Structure for
PPP4R3A
ECgene alternative splicing isoforms for
PPP4R3A

Expression for PPP4R3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PPP4R3A Gene:

PPP4R3A
genes like me logo Genes that share expression patterns with PPP4R3A: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PPP4R3A Gene

Orthologs for PPP4R3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP4R3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMEK1 34 35
  • 99.72 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SMEK1 34 35
  • 95.53 (n)
cow
(Bos Taurus)
Mammalia SMEK1 34 35
  • 94.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SMEK1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smek1 34 16 35
  • 93.29 (n)
oppossum
(Monodelphis domestica)
Mammalia SMEK1 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smek1 34
  • 92.36 (n)
chicken
(Gallus gallus)
Aves SMEK1 34 35
  • 85.65 (n)
lizard
(Anolis carolinensis)
Reptilia SMEK1 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485426 34
  • 80.85 (n)
zebrafish
(Danio rerio)
Actinopterygii smek1 34 35
  • 74.37 (n)
wufj55c11 34
fruit fly
(Drosophila melanogaster)
Insecta flfl 35
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea smk-1 34 35
  • 51.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSY2 35
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06670 34
  • 48.13 (n)
rice
(Oryza sativa)
Liliopsida Os01g0337600 34
  • 49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC216.01c 34
  • 47.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11315 34
  • 43.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4515 34
Species where no ortholog for PPP4R3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP4R3A Gene

ENSEMBL:
Gene Tree for PPP4R3A (if available)
TreeFam:
Gene Tree for PPP4R3A (if available)

Paralogs for PPP4R3A Gene

Paralogs for PPP4R3A Gene

genes like me logo Genes that share paralogs with PPP4R3A: view

Variants for PPP4R3A Gene

Sequence variations from dbSNP and Humsavar for PPP4R3A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10129510 -- 91,487,382(+) TCATA(C/T)AAGAA intron-variant
rs10131200 -- 91,490,892(+) AAAAA(A/T)AATAA intron-variant
rs10134560 -- 91,463,808(+) ttata(C/T)gggta intron-variant
rs10135595 -- 91,458,683(+) GCTTT(G/T)TTGTG nc-transcript-variant, utr-variant-3-prime
rs10137129 -- 91,507,420(+) ATATA(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4R3A Gene

Variant ID Type Subtype PubMed ID
esv2333297 CNV deletion 18987734
esv2555842 CNV deletion 19546169
esv2662799 CNV deletion 23128226
esv3635324 CNV loss 21293372
nsv472301 CNV novel sequence insertion 20440878

Variation tolerance for PPP4R3A Gene

Residual Variation Intolerance Score: 4.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP4R3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP4R3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R3A Gene

Disorders for PPP4R3A Gene

Relevant External Links for PPP4R3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP4R3A

No disorders were found for PPP4R3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP4R3A Gene

Publications for PPP4R3A Gene

  1. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. (PMID: 18487071) Martin-Granados C. … Cohen P.T.W. (Int. J. Biochem. Cell Biol. 2008) 2 3 4 64
  2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras A.-C. … Aebersold R. (Mol. Cell. Proteomics 2005) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for PPP4R3A Gene

Sources for PPP4R3A Gene

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