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Aliases for PPP4R3A Gene

Aliases for PPP4R3A Gene

  • Protein Phosphatase 4 Regulatory Subunit 3A 2 3 5
  • KIAA2010 2 3 4
  • Protein Phosphatase 4, Regulatory Subunit 3A 2 3
  • PP4R3A 3 4
  • SMEK1 3 4
  • SMEK Homolog 1, Suppressor Of Mek1 (Dictyostelium) 2
  • SMEK Homolog 1, Suppressor Of Mek1 3
  • SMEK Homolog 1 4
  • MSTP033 3
  • FLFL1 3
  • PP4R3 3
  • Smk-1 3
  • Smk1 3

External Ids for PPP4R3A Gene

Previous HGNC Symbols for PPP4R3A Gene

  • KIAA2010
  • SMEK1

Summaries for PPP4R3A Gene

GeneCards Summary for PPP4R3A Gene

PPP4R3A (Protein Phosphatase 4 Regulatory Subunit 3A) is a Protein Coding gene. Among its related pathways are Glucagon signaling pathway and Integrated Breast Cancer Pathway. An important paralog of this gene is PPP4R3B.

UniProtKB/Swiss-Prot for PPP4R3A Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R3A Gene

Genomics for PPP4R3A Gene

Regulatory Elements for PPP4R3A Gene

Enhancers for PPP4R3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP4R3A on UCSC Golden Path with GeneCards custom track

Promoters for PPP4R3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP4R3A on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP4R3A Gene

Chromosome:
14
Start:
91,457,481 bp from pter
End:
91,510,554 bp from pter
Size:
53,074 bases
Orientation:
Minus strand

Genomic View for PPP4R3A Gene

Genes around PPP4R3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP4R3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP4R3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R3A Gene

Proteins for PPP4R3A Gene

  • Protein details for PPP4R3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IN85-P4R3A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Protein Accession:
    Q6IN85
    Secondary Accessions:
    • Q69YK6
    • Q86U23
    • Q86YI7
    • Q8IVG1
    • Q9H3F1
    • Q9H7U8
    • Q9NV01
    • Q9NWP1

    Protein attributes for PPP4R3A Gene

    Size:
    833 amino acids
    Molecular mass:
    95368 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.
    SequenceCaution:
    • Sequence=AAG39284.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAA91960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91960.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence={ECO:0000305}; Sequence=BAB14877.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC23106.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP4R3A Gene

Proteomics data for PPP4R3A Gene at MOPED

Post-translational modifications for PPP4R3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP4R3A Gene

Domains & Families for PPP4R3A Gene

Protein Domains for PPP4R3A Gene

Suggested Antigen Peptide Sequences for PPP4R3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IN85

UniProtKB/Swiss-Prot:

P4R3A_HUMAN :
  • Contains 1 WH1 domain.
  • Belongs to the SMEK family.
Domain:
  • Contains 1 WH1 domain.
Family:
  • Belongs to the SMEK family.
genes like me logo Genes that share domains with PPP4R3A: view

No data available for Gene Families for PPP4R3A Gene

Function for PPP4R3A Gene

Molecular function for PPP4R3A Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
genes like me logo Genes that share phenotypes with PPP4R3A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP4R3A Gene

Localization for PPP4R3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP4R3A Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.

Gene Ontology (GO) - Cellular Components for PPP4R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with PPP4R3A: view

No data available for Subcellular locations from COMPARTMENTS for PPP4R3A Gene

Pathways & Interactions for PPP4R3A Gene

genes like me logo Genes that share pathways with PPP4R3A: view

Pathways by source for PPP4R3A Gene

1 BioSystems pathway for PPP4R3A Gene
1 KEGG pathway for PPP4R3A Gene

Interacting Proteins for PPP4R3A Gene

SIGNOR curated interactions for PPP4R3A Gene

Activates:

Gene Ontology (GO) - Biological Process for PPP4R3A Gene

None

Drugs & Compounds for PPP4R3A Gene

No Compound Related Data Available

Transcripts for PPP4R3A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R3A Gene

No ASD Table

Relevant External Links for PPP4R3A Gene

GeneLoc Exon Structure for
PPP4R3A
ECgene alternative splicing isoforms for
PPP4R3A

Expression for PPP4R3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with PPP4R3A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPP4R3A Gene

Orthologs for PPP4R3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP4R3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMEK1 35
  • 94.35 (n)
  • 98.78 (a)
SMEK1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMEK1 35
  • 95.53 (n)
  • 99.39 (a)
SMEK1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smek1 35
  • 93.29 (n)
  • 99.27 (a)
Smek1 16
Smek1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMEK1 35
  • 99.72 (n)
  • 100 (a)
-- 36
  • 99 (a)
OneToMany
SMEK1 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Smek1 35
  • 92.36 (n)
  • 99.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SMEK1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMEK1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMEK1 35
  • 85.65 (n)
  • 97.56 (a)
SMEK1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMEK1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485426 35
  • 80.85 (n)
  • 92.07 (a)
zebrafish
(Danio rerio)
Actinopterygii smek1 35
  • 74.37 (n)
  • 88.21 (a)
wufj55c11 35
smek1 36
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta flfl 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea smk-1 35
  • 51.68 (n)
  • 43.76 (a)
smk-1 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSY2 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06670 35
  • 48.13 (n)
  • 36.88 (a)
rice
(Oryza sativa)
Liliopsida Os01g0337600 35
  • 49 (n)
  • 35.48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4515 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11315 35
  • 43.37 (n)
  • 30.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC216.01c 35
  • 47.9 (n)
  • 35.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for PPP4R3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP4R3A Gene

ENSEMBL:
Gene Tree for PPP4R3A (if available)
TreeFam:
Gene Tree for PPP4R3A (if available)

Paralogs for PPP4R3A Gene

Paralogs for PPP4R3A Gene

genes like me logo Genes that share paralogs with PPP4R3A: view

Variants for PPP4R3A Gene

Sequence variations from dbSNP and Humsavar for PPP4R3A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7493799 -- 91,497,840(+) acaat(C/T)taTAC intron-variant
rs7494224 -- 91,503,617(+) ggatg(C/G)tgggc intron-variant
rs8003094 -- 91,508,528(+) GTTTG(A/G)AAGTA intron-variant
rs8003256 -- 91,495,693(+) TGTTA(A/G)AAAAA intron-variant
rs7142852 -- 91,460,834(+) cagga(C/T)ggtct intron-variant

Variation tolerance for PPP4R3A Gene

Residual Variation Intolerance Score: 4.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PPP4R3A Gene

Disorders for PPP4R3A Gene

Relevant External Links for PPP4R3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP4R3A

No disorders were found for PPP4R3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP4R3A Gene

Publications for PPP4R3A Gene

  1. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. (PMID: 18487071) Martin-Granados C. … Cohen P.T.W. (Int. J. Biochem. Cell Biol. 2008) 2 3 4 67
  2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras A.-C. … Aebersold R. (Mol. Cell. Proteomics 2005) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PPP4R3A Gene

Sources for PPP4R3A Gene

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