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Aliases for PPP4R2 Gene

Aliases for PPP4R2 Gene

  • Protein Phosphatase 4 Regulatory Subunit 2 2 3 5
  • Protein Phosphatase 4, Regulatory Subunit 2 2 3
  • PP4R2 3

External Ids for PPP4R2 Gene

Previous GeneCards Identifiers for PPP4R2 Gene

  • GC03P191644
  • GC03P199238
  • GC03P072851
  • GC03P072966
  • GC03P073128
  • GC03P073045

Summaries for PPP4R2 Gene

Entrez Gene Summary for PPP4R2 Gene

  • The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for PPP4R2 Gene

PPP4R2 (Protein Phosphatase 4 Regulatory Subunit 2) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair. GO annotations related to this gene include protein binding, bridging and protein phosphatase type 4 regulator activity.

UniProtKB/Swiss-Prot for PPP4R2 Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R2 Gene

Genomics for PPP4R2 Gene

Regulatory Elements for PPP4R2 Gene

Promoters for PPP4R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP4R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP4R2 Gene

Chromosome:
3
Start:
72,996,785 bp from pter
End:
73,069,199 bp from pter
Size:
72,415 bases
Orientation:
Plus strand

Genomic View for PPP4R2 Gene

Genes around PPP4R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP4R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP4R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R2 Gene

Proteins for PPP4R2 Gene

  • Protein details for PPP4R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY27-PP4R2_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 2
    Protein Accession:
    Q9NY27
    Secondary Accessions:
    • A8K1I6
    • Q2TAJ9
    • Q498B8
    • Q8WXX6

    Protein attributes for PPP4R2 Gene

    Size:
    417 amino acids
    Molecular mass:
    46898 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A and PPP4C-PPP4R2-PPP4R3B. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with DDX20/GEMIN3 and GEMIN4. Interacts with RPA2; this DNA damage-dependent interaction recruits PPP4C leading to RPA2 dephosphorylation.
    SequenceCaution:
    • Sequence=AAI00282.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAB93534.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP4R2 Gene

Proteomics data for PPP4R2 Gene at MOPED

Post-translational modifications for PPP4R2 Gene

  • Ubiquitination at Lys 15, Lys 55, Lys 84, and Lys 141
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PPP4R2

No data available for DME Specific Peptides for PPP4R2 Gene

Domains & Families for PPP4R2 Gene

Gene Families for PPP4R2 Gene

Protein Domains for PPP4R2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP4R2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY27

UniProtKB/Swiss-Prot:

PP4R2_HUMAN :
  • Belongs to the PPP4R2 family.
Family:
  • Belongs to the PPP4R2 family.
genes like me logo Genes that share domains with PPP4R2: view

Function for PPP4R2 Gene

Molecular function for PPP4R2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

Gene Ontology (GO) - Molecular Function for PPP4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085932
GO:0030674 protein binding, bridging IMP 20154705
genes like me logo Genes that share ontologies with PPP4R2: view
genes like me logo Genes that share phenotypes with PPP4R2: view

Animal Models for PPP4R2 Gene

MGI Knock Outs for PPP4R2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP4R2 Gene

Localization for PPP4R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP4R2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP4R2 Gene COMPARTMENTS Subcellular localization image for PPP4R2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030289 protein phosphatase 4 complex IDA 20154705
genes like me logo Genes that share ontologies with PPP4R2: view

Pathways & Interactions for PPP4R2 Gene

genes like me logo Genes that share pathways with PPP4R2: view

Gene Ontology (GO) - Biological Process for PPP4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006464 cellular protein modification process TAS 10769191
GO:0008380 RNA splicing IEA --
GO:0010569 regulation of double-strand break repair via homologous recombination IMP 20154705
GO:0050790 regulation of catalytic activity IMP 20154705
genes like me logo Genes that share ontologies with PPP4R2: view

No data available for SIGNOR curated interactions for PPP4R2 Gene

Drugs & Compounds for PPP4R2 Gene

No Compound Related Data Available

Transcripts for PPP4R2 Gene

mRNA/cDNA for PPP4R2 Gene

Unigene Clusters for PPP4R2 Gene

Protein phosphatase 4, regulatory subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R2 Gene

No ASD Table

Relevant External Links for PPP4R2 Gene

GeneLoc Exon Structure for
PPP4R2
ECgene alternative splicing isoforms for
PPP4R2

Expression for PPP4R2 Gene

mRNA expression in normal human tissues for PPP4R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP4R2 Gene

This gene is overexpressed in Adrenal (17.8), Lung (16.2), Testis (15.0), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP4R2 Gene



SOURCE GeneReport for Unigene cluster for PPP4R2 Gene Hs.431092

mRNA Expression by UniProt/SwissProt for PPP4R2 Gene

Q9NY27-PP4R2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PPP4R2: view

Protein tissue co-expression partners for PPP4R2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP4R2 Gene

Orthologs for PPP4R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP4R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP4R2 36
  • 100 (a)
OneToOne
PPP4R2 35
  • 99.6 (n)
  • 99.52 (a)
cow
(Bos Taurus)
Mammalia PPP4R2 36
  • 93 (a)
OneToOne
PPP4R2 35
  • 94.09 (n)
  • 93.45 (a)
dog
(Canis familiaris)
Mammalia PPP4R2 35
  • 94.75 (n)
  • 94.83 (a)
PPP4R2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp4r2 16
Ppp4r2 35
  • 85.59 (n)
  • 83.09 (a)
Ppp4r2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP4R2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP4R2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp4r2 35
  • 85.55 (n)
  • 81.6 (a)
chicken
(Gallus gallus)
Aves PPP4R2 35
  • 79.42 (n)
  • 79.51 (a)
PPP4R2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP4R2 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7493 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp4r2 35
  • 69.08 (n)
  • 65.5 (a)
Str.4043 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14202 35
zebrafish
(Danio rerio)
Actinopterygii ppp4r2a 36
  • 50 (a)
OneToMany
ppp4r2b 36
  • 47 (a)
OneToMany
wufe11b04 35
fruit fly
(Drosophila melanogaster)
Insecta PPP4R2r 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ppfr-2 36
  • 16 (a)
OneToOne
Species with no ortholog for PPP4R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP4R2 Gene

ENSEMBL:
Gene Tree for PPP4R2 (if available)
TreeFam:
Gene Tree for PPP4R2 (if available)

Paralogs for PPP4R2 Gene

genes like me logo Genes that share paralogs with PPP4R2: view

No data available for Paralogs for PPP4R2 Gene

Variants for PPP4R2 Gene

Sequence variations from dbSNP and Humsavar for PPP4R2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs34742137 - 73,065,058(+) TTCAT(C/G)TCAGG reference, missense
rs2306983 - 73,064,029(-) GCCTG(A/G)GTGTC reference, missense
rs749294 -- 73,015,259(-) gaggt(G/T)gcagt intron-variant
rs749295 -- 73,015,226(-) ctcca(C/G)cctgg intron-variant
rs755590 -- 73,007,834(-) TACTA(C/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4R2 Gene

Variant ID Type Subtype PubMed ID
nsv513052 CNV Loss 21212237
esv2667846 CNV Deletion 23128226
nsv238064 CNV Insertion 16902084
nsv528982 CNV Gain 19592680
nsv460703 CNV Loss 19166990

Variation tolerance for PPP4R2 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP4R2 Gene

HapMap Linkage Disequilibrium report
PPP4R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R2 Gene

Disorders for PPP4R2 Gene

Relevant External Links for PPP4R2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP4R2

No disorders were found for PPP4R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP4R2 Gene

Publications for PPP4R2 Gene

  1. A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres. (PMID: 10769191) Hastie C.J. … Cohen P.T.W. (Biochem. J. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for PPP4R2 Gene

Sources for PPP4R2 Gene

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