External Ids for PPP4R2 Gene
Previous GeneCards Identifiers for PPP4R2 Gene
GeneCards Summary for PPP4R2 Gene
PPP4R2 (Protein Phosphatase 4, Regulatory Subunit 2) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair. GO annotations related to this gene include protein binding, bridging and protein phosphatase type 4 regulator activity.
UniProtKB/Swiss-Prot for PPP4R2 Gene
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.