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Aliases for PPP4R1L Gene

Aliases for PPP4R1L Gene

  • Protein Phosphatase 4 Regulatory Subunit 1 Like (Pseudogene) 2 3 5
  • Protein Phosphatase 4, Regulatory Subunit 1-Like 2 3
  • C20orf192 3 4
  • Protein Phosphatase 4, Regulatory Subunit 1-Like (Pseudogene) 2
  • Protein Phosphatase 4, Regulatory Subunit 1 Pseudogene 3
  • PPP4R1P1 3
  • PRO1085 3

External Ids for PPP4R1L Gene

Previous HGNC Symbols for PPP4R1L Gene

  • C20orf192

Previous GeneCards Identifiers for PPP4R1L Gene

  • GC20M056534
  • GC20M057444
  • GC20M057491
  • GC20M057492
  • GC20M056239
  • GC20M056246
  • GC20M056806
  • GC20M053590

Summaries for PPP4R1L Gene

GeneCards Summary for PPP4R1L Gene

PPP4R1L (Protein Phosphatase 4 Regulatory Subunit 1 Like (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for PPP4R1L Gene

  • May be a regulatory subunit of serine/threonine-protein phosphatase 4.

Additional gene information for PPP4R1L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R1L Gene

Genomics for PPP4R1L Gene

Regulatory Elements for PPP4R1L Gene

Enhancers for PPP4R1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H058649 1.5 ENCODE dbSUPER 40.2 -342.6 -342631 5.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC LOC101927932 PPP4R1L NELFCD ENSG00000254419 STX16 NPEPL1 ENSG00000270279 PIEZO1P2 ANKRD60 ENSG00000227282
GH20H058622 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.9 -314.4 -314368 2.9 HDGF PKNOX1 SIN3A YBX1 ZBTB7B ZNF207 FOS REST SMARCB1 ZNF592 NELFCD LOC101927932 PPP4R1L STX16 ENSG00000270279 PIEZO1P2 ANKRD60 ENSG00000227282 ENSG00000254419 PIR40957
GH20H057409 1.6 FANTOM5 ENCODE dbSUPER 20.9 +899.6 899642 2.4 HDGF PKNOX1 ATF1 ARNT ZBTB7B TCF12 GTF3C2 ZNF766 GLIS2 GATA2 ENSG00000280387 PPP4R1L FAM209A GCNT7 RBM38 CTCFL ZBP1 LOC100291105 PIR61563
GH20H058236 1.3 Ensembl ENCODE 23.7 +71.9 71886 2.3 SIN3A YBX1 ZBTB7B ZNF207 ZNF143 FOS RUNX3 SP5 MXD4 REST PPP4R1L RAE1 RAB22A ENSG00000254419 ANKRD60
GH20H058372 1.2 Ensembl ENCODE 24.2 -65.0 -65048 4.2 HDGF ATF1 TCF12 ZNF207 REST MIER2 ZNF592 KAT8 MEF2D NFIL3 PPP4R1L RAB22A ANKRD60 APCDD1L APCDD1L-AS1 ENSG00000254419 VAPB PIR40663
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP4R1L on UCSC Golden Path with GeneCards custom track

Promoters for PPP4R1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139359 -361 2001 ATF1 SIN3A YY1 GLIS2 ELK1 FOS KLF7 ATF7 SP3 SP5

Genomic Locations for PPP4R1L Gene

Genomic Locations for PPP4R1L Gene
chr20:58,228,940-58,309,439
(GRCh38/hg38)
Size:
80,500 bases
Orientation:
Minus strand
chr20:56,806,188-56,884,495
(GRCh37/hg19)

Genomic View for PPP4R1L Gene

Genes around PPP4R1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP4R1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP4R1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R1L Gene

Proteins for PPP4R1L Gene

  • Protein details for PPP4R1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1A2-PP4RL_HUMAN
    Recommended name:
    Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like
    Protein Accession:
    Q9P1A2
    Secondary Accessions:
    • B4DRM4
    • Q96LY6
    • Q9BZ17
    • Q9BZ18

    Protein attributes for PPP4R1L Gene

    Size:
    415 amino acids
    Molecular mass:
    45908 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69597.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP4R1L Gene

Post-translational modifications for PPP4R1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP4R1L Gene

Domains & Families for PPP4R1L Gene

Protein Domains for PPP4R1L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP4R1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PPP4R1L Gene

Function for PPP4R1L Gene

Molecular function for PPP4R1L Gene

UniProtKB/Swiss-Prot Function:
May be a regulatory subunit of serine/threonine-protein phosphatase 4.

Phenotypes From GWAS Catalog for PPP4R1L Gene

Gene Ontology (GO) - Molecular Function for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 10026142
genes like me logo Genes that share ontologies with PPP4R1L: view
genes like me logo Genes that share phenotypes with PPP4R1L: view

Animal Model Products

miRNA for PPP4R1L Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP4R1L Gene

Localization for PPP4R1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP4R1L gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PPP4R1L Gene

Pathways & Interactions for PPP4R1L Gene

SuperPathways for PPP4R1L Gene

No Data Available

Interacting Proteins for PPP4R1L Gene

Selected Interacting proteins: Q9P1A2-PP4RL_HUMAN for PPP4R1L Gene via IID

Gene Ontology (GO) - Biological Process for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

No data available for Pathways by source and SIGNOR curated interactions for PPP4R1L Gene

Drugs & Compounds for PPP4R1L Gene

No Compound Related Data Available

Transcripts for PPP4R1L Gene

mRNA/cDNA for PPP4R1L Gene

Unigene Clusters for PPP4R1L Gene

Protein phosphatase 4, regulatory subunit 1-like:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5: - - -
SP6: -
SP7:

ExUns: 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PPP4R1L Gene

GeneLoc Exon Structure for
PPP4R1L
ECgene alternative splicing isoforms for
PPP4R1L

Expression for PPP4R1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP4R1L Gene

mRNA differential expression in normal tissues according to GTEx for PPP4R1L Gene

This gene is overexpressed in Whole Blood (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of PPP4R1L Gene:

PPP4R1L

SOURCE GeneReport for Unigene cluster for PPP4R1L Gene:

Hs.473179

Evidence on tissue expression from TISSUES for PPP4R1L Gene

  • Heart(2.6)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with PPP4R1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP4R1L Gene

Orthologs for PPP4R1L Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP4R1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP4R1L 34
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP4R1L 34
  • 19 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP4R1L 34
  • 19 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP4R1L 34
  • 15 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP4R1L 34
  • 15 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP4R1L 34
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PPP4R1L 34
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ppfr-1 34
  • 4 (a)
OneToMany
Species where no ortholog for PPP4R1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPP4R1L Gene

ENSEMBL:
Gene Tree for PPP4R1L (if available)
TreeFam:
Gene Tree for PPP4R1L (if available)

Paralogs for PPP4R1L Gene

(1) SIMAP similar genes for PPP4R1L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP4R1L: view

No data available for Paralogs for PPP4R1L Gene

Variants for PPP4R1L Gene

Sequence variations from dbSNP and Humsavar for PPP4R1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000041489 -- 58,245,764(+) TTAAT(A/G)ACAAT intron-variant
rs1000058905 -- 58,238,861(+) AGCAG(C/T)AGCGA intron-variant
rs1000069518 -- 58,282,112(+) TGAGT(A/C)TTTGA intron-variant
rs1000072532 -- 58,246,131(+) TTCCA(C/T)AGGGC nc-transcript-variant
rs1000133627 -- 58,288,213(+) ATGAT(G/T)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4R1L Gene

Variant ID Type Subtype PubMed ID
nsv1061416 CNV gain 25217958
nsv1055956 CNV gain 25217958
esv2722620 CNV deletion 23290073

Variation tolerance for PPP4R1L Gene

Gene Damage Index Score: 6.29; 76.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP4R1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP4R1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R1L Gene

Disorders for PPP4R1L Gene

Relevant External Links for PPP4R1L

Genetic Association Database (GAD)
PPP4R1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP4R1L

No disorders were found for PPP4R1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP4R1L Gene

Publications for PPP4R1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4 60
  3. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson AD … Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (Diabetes 2010) 45 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  5. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y … He F (Genome research 2001) 3 60

Products for PPP4R1L Gene

Sources for PPP4R1L Gene

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