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Aliases for PPP4R1L Gene

Aliases for PPP4R1L Gene

  • Protein Phosphatase 4, Regulatory Subunit 1-Like (Pseudogene) 2 3
  • C20orf192 3 4
  • Protein Phosphatase 4, Regulatory Subunit 1 Pseudogene 3
  • Protein Phosphatase 4, Regulatory Subunit 1-Like 2
  • PPP4R1P1 3
  • PRO1085 3

External Ids for PPP4R1L Gene

Previous HGNC Symbols for PPP4R1L Gene

  • C20orf192

Previous GeneCards Identifiers for PPP4R1L Gene

  • GC20M056534
  • GC20M057444
  • GC20M057491
  • GC20M057492
  • GC20M056239
  • GC20M056246
  • GC20M056806
  • GC20M053590

Summaries for PPP4R1L Gene

GeneCards Summary for PPP4R1L Gene

PPP4R1L (Protein Phosphatase 4, Regulatory Subunit 1-Like (Pseudogene)) is a Pseudogene. An important paralog of this gene is PPP4R1.

UniProtKB/Swiss-Prot for PPP4R1L Gene

  • May be a regulatory subunit of serine/threonine-protein phosphatase 4

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R1L Gene

Genomics for PPP4R1L Gene

Regulatory Elements for PPP4R1L Gene

Genomic Location for PPP4R1L Gene

Chromosome:
20
Start:
58,228,940 bp from pter
End:
58,309,439 bp from pter
Size:
80,500 bases
Orientation:
Minus strand

Genomic View for PPP4R1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PPP4R1L Gene

Proteins for PPP4R1L Gene

  • Protein details for PPP4R1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1A2-PP4RL_HUMAN
    Recommended name:
    Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like
    Protein Accession:
    Q9P1A2
    Secondary Accessions:
    • B4DRM4
    • Q96LY6
    • Q9BZ17
    • Q9BZ18

    Protein attributes for PPP4R1L Gene

    Size:
    415 amino acids
    Molecular mass:
    45908 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69597.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP4R1L Gene

Proteomics data for PPP4R1L Gene at MOPED

Post-translational modifications for PPP4R1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP4R1L Gene

Domains & Families for PPP4R1L Gene

Protein Domains for PPP4R1L Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1A2

UniProtKB/Swiss-Prot:

PP4RL_HUMAN :
  • Contains 4 HEAT repeats.
Similarity:
  • Contains 4 HEAT repeats.
genes like me logo Genes that share domains with PPP4R1L: view

No data available for Gene Families for PPP4R1L Gene

Function for PPP4R1L Gene

Molecular function for PPP4R1L Gene

UniProtKB/Swiss-Prot Function:
May be a regulatory subunit of serine/threonine-protein phosphatase 4

Gene Ontology (GO) - Molecular Function for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

Phenotypes for PPP4R1L Gene

genes like me logo Genes that share phenotypes with PPP4R1L: view

miRNA for PPP4R1L Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP4R1L Gene

Localization for PPP4R1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP4R1L Gene COMPARTMENTS Subcellular localization image for PPP4R1L gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP4R1L Gene

Pathways & Interactions for PPP4R1L Gene

SuperPathways for PPP4R1L Gene

No Data Available

Interacting Proteins for PPP4R1L Gene

Gene Ontology (GO) - Biological Process for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

No data available for Pathways by source and SIGNOR curated interactions for PPP4R1L Gene

Drugs & Compounds for PPP4R1L Gene

No Compound Related Data Available

Transcripts for PPP4R1L Gene

Unigene Clusters for PPP4R1L Gene

Protein phosphatase 4, regulatory subunit 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5: - - -
SP6: -
SP7:

ExUns: 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PPP4R1L Gene

GeneLoc Exon Structure for
PPP4R1L
ECgene alternative splicing isoforms for
PPP4R1L

Expression for PPP4R1L Gene

mRNA expression in normal human tissues for PPP4R1L Gene

mRNA differential expression in normal tissues according to GTEx for PPP4R1L Gene

This gene is overexpressed in Whole Blood (x4.3).

SOURCE GeneReport for Unigene cluster for PPP4R1L Gene Hs.473179

genes like me logo Genes that share expression patterns with PPP4R1L: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPP4R1L Gene

Orthologs for PPP4R1L Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP4R1L Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PPP4R1L 36
  • 19 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP4R1L 36
  • 19 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP4R1L 36
  • 15 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP4R1L 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP4R1L 36
  • 15 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP4R1L 36
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PPP4R1L 36
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ppfr-1 36
  • 4 (a)
OneToMany
Species with no ortholog for PPP4R1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPP4R1L Gene

ENSEMBL:
Gene Tree for PPP4R1L (if available)
TreeFam:
Gene Tree for PPP4R1L (if available)

Paralogs for PPP4R1L Gene

Paralogs for PPP4R1L Gene

(1) SIMAP similar genes for PPP4R1L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP4R1L: view

Variants for PPP4R1L Gene

Sequence variations from dbSNP and Humsavar for PPP4R1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs474212 -- 58,236,344(+) AAAAA(A/C)AAAAT intron-variant
rs503900 -- 58,235,428(+) AATTA(C/T)GAATA intron-variant
rs511444 -- 58,250,591(+) TTCTA(A/G)AAAGA intron-variant
rs514706 -- 58,240,822(+) AGTGC(A/T)AAGGA intron-variant
rs518929 -- 58,248,339(+) GTTTT(A/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4R1L Gene

Variant ID Type Subtype PubMed ID
esv2722620 CNV Deletion 23290073

Variation tolerance for PPP4R1L Gene

Gene Damage Index Score: 6.29; 76.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP4R1L Gene

HapMap Linkage Disequilibrium report
PPP4R1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R1L Gene

Disorders for PPP4R1L Gene

Relevant External Links for PPP4R1L

Genetic Association Database (GAD)
PPP4R1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP4R1L
genes like me logo Genes that share disorders with PPP4R1L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP4R1L Gene

Publications for PPP4R1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 67
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 67
  3. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67
  5. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 67

Products for PPP4R1L Gene

Sources for PPP4R1L Gene

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