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Aliases for PPP4R1L Gene

Aliases for PPP4R1L Gene

  • Protein Phosphatase 4, Regulatory Subunit 1-Like (Pseudogene) 2 3
  • C20orf192 3 4
  • Protein Phosphatase 4, Regulatory Subunit 1 Pseudogene 3
  • Protein Phosphatase 4, Regulatory Subunit 1-Like 2
  • PPP4R1P1 3
  • PRO1085 3

External Ids for PPP4R1L Gene

Previous HGNC Symbols for PPP4R1L Gene

  • C20orf192

Previous GeneCards Identifiers for PPP4R1L Gene

  • GC20M056534
  • GC20M057444
  • GC20M057491
  • GC20M057492
  • GC20M056239
  • GC20M056246
  • GC20M056806
  • GC20M053590

Summaries for PPP4R1L Gene

GeneCards Summary for PPP4R1L Gene

PPP4R1L (Protein Phosphatase 4, Regulatory Subunit 1-Like (Pseudogene)) is a Pseudogene. An important paralog of this gene is PPP4R1.

UniProtKB/Swiss-Prot for PPP4R1L Gene

  • May be a regulatory subunit of serine/threonine-protein phosphatase 4

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R1L Gene

Genomics for PPP4R1L Gene

Regulatory Elements for PPP4R1L Gene

Genomic Location for PPP4R1L Gene

Start:
58,228,940 bp from pter
End:
58,309,439 bp from pter
Size:
80,500 bases
Orientation:
Minus strand

Genomic View for PPP4R1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP4R1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R1L Gene

Proteins for PPP4R1L Gene

  • Protein details for PPP4R1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1A2-PP4RL_HUMAN
    Recommended name:
    Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like
    Protein Accession:
    Q9P1A2
    Secondary Accessions:
    • B4DRM4
    • Q96LY6
    • Q9BZ17
    • Q9BZ18

    Protein attributes for PPP4R1L Gene

    Size:
    415 amino acids
    Molecular mass:
    45908 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69597.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP4R1L Gene

Proteomics data for PPP4R1L Gene at MOPED

Post-translational modifications for PPP4R1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP4R1L Gene

Domains for PPP4R1L Gene

Protein Domains for PPP4R1L Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P1A2

UniProtKB/Swiss-Prot:

PP4RL_HUMAN :
  • Q9P1A2
Similarity:
  • Contains 4 HEAT repeats.
genes like me logo Genes that share domains with PPP4R1L: view

No data available for Gene Families for PPP4R1L Gene

Function for PPP4R1L Gene

Molecular function for PPP4R1L Gene

UniProtKB/Swiss-Prot Function: May be a regulatory subunit of serine/threonine-protein phosphatase 4

Gene Ontology (GO) - Molecular Function for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

Phenotypes for PPP4R1L Gene

genes like me logo Genes that share phenotypes with PPP4R1L: view

miRNA for PPP4R1L Gene

miRTarBase miRNAs that target PPP4R1L

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP4R1L Gene

Localization for PPP4R1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP4R1L Gene COMPARTMENTS Subcellular localization image for PPP4R1L gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP4R1L Gene

Pathways for PPP4R1L Gene

SuperPathways for PPP4R1L Gene

No Data Available

Interacting Proteins for PPP4R1L Gene

Gene Ontology (GO) - Biological Process for PPP4R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PPP4R1L: view

No data available for Pathways by source for PPP4R1L Gene

Transcripts for PPP4R1L Gene

Unigene Clusters for PPP4R1L Gene

Protein phosphatase 4, regulatory subunit 1-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP4R1L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PPP4R1L
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5: - - -
SP6: -
SP7:

ExUns: 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PPP4R1L Gene

GeneLoc Exon Structure for
PPP4R1L
ECgene alternative splicing isoforms for
PPP4R1L

Expression for PPP4R1L Gene

mRNA expression in normal human tissues for PPP4R1L Gene

mRNA differential expression in normal tissues according to GTEx for PPP4R1L Gene

This gene is overexpressed in Whole Blood (4.3).

SOURCE GeneReport for Unigene cluster for PPP4R1L Gene Hs.473179

genes like me logo Genes that share expressions with PPP4R1L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for PPP4R1L Gene

Orthologs for PPP4R1L Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP4R1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP4R1L 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP4R1L 36
  • 19 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP4R1L 36
  • 19 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP4R1L 36
  • 15 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP4R1L 36
  • 15 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP4R1L 36
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PPP4R1L 36
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ppfr-1 36
  • 4 (a)
OneToMany
Species with no ortholog for PPP4R1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPP4R1L Gene

ENSEMBL:
Gene Tree for PPP4R1L (if available)
TreeFam:
Gene Tree for PPP4R1L (if available)

Paralogs for PPP4R1L Gene

Paralogs for PPP4R1L Gene

Selected SIMAP similar genes for PPP4R1L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP4R1L: view

Variants for PPP4R1L Gene

Sequence variations from dbSNP and Humsavar for PPP4R1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs472191 -- 58,305,502(+) TAGAT(A/C)ATGCG intron-variant
rs474212 -- 58,236,344(+) AAAAA(A/C)AAAAT intron-variant
rs480143 -- 58,304,499(+) AAATG(G/T)ATCTT intron-variant
rs482956 -- 58,304,207(+) CAGAT(A/G)ACATG intron-variant
rs503900 -- 58,235,428(+) AATTA(C/T)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4R1L Gene

Variant ID Type Subtype PubMed ID
esv2722620 CNV Deletion 23290073

Relevant External Links for PPP4R1L Gene

HapMap Linkage Disequilibrium report
PPP4R1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R1L Gene

Disorders for PPP4R1L Gene

Relevant External Links for PPP4R1L

Genetic Association Database (GAD)
PPP4R1L
genes like me logo Genes that share disorders with PPP4R1L: view

No data available for UniProtKB/Swiss-Prot for PPP4R1L Gene

Publications for PPP4R1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for PPP4R1L Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate PPP4R1L
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PPP4R1L
    • Block miRNA regulation of PPP4R1L using miScript Target Protectors

    Sources for PPP4R1L Gene

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