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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP4R1L Gene

protein-coding   GIFtS: 39
GCID: GC20M056806

Protein Phosphatase 4, Regulatory Subunit 1-Like


(Previous symbol: C20orf192)
  Search for PPP4R1L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Phosphatase 4, Regulatory Subunit 1-Like1 2
C20orf1921 2 3
PRO10852

External Ids:    HGNC: 157551   Entrez Gene: 553702   Ensembl: ENSG000001242247   UniProtKB: Q9P1A23   
ORGUL members:         
NONCODE14:n406117      

Export aliases for PPP4R1L gene to outside databases

Previous GC identifers: GC20M056534 GC20M057444 GC20M057491 GC20M057492 GC20M056239 GC20M056246 GC20M053590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPP4R1L Gene: 
PPP4R1L (protein phosphatase 4, regulatory subunit 1-like) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include molecular_function. An important paralog of this gene is PPP4R1.

UniProtKB/Swiss-Prot: PP4RL_HUMAN, Q9P1A2
Function: May be a regulatory subunit of serine/threonine-protein phosphatase 4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP4R1L gene promoter:
         SRF   AP-1   SRF (504 AA)   c-Ets-1   CREB   deltaCREB   COMP1   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PPP4R1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP4R1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13.32

PPP4R1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP4R1L gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M056806:  view genomic region     (about GC identifiers)

Start:
56,806,188 bp from pter      End:
56,884,495 bp from pter
Size:
78,308 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PP4RL_HUMAN, Q9P1A2 (See protein sequence)
Recommended Name: Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like  
Size: 415 amino acids; 45908 Da
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AAF69597.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame;
Secondary accessions: B4DRM4 Q9BZ17 Q9BZ18

Explore the universe of human proteins at neXtProt for PPP4R1L: NX_Q9P1A2

PPP4R1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

ENSEMBL proteins: 
 ENSP00000435205   ENSP00000402088   ENSP00000435897   ENSP00000244070   ENSP00000388468  
 ENSP00000335579  

Human Recombinant Protein Products for PPP4R1L: 
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Novus Biologicals PPP4R1L Lysate
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Browse Sino Biological Cell Lysates 
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Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--

PPP4R1L for ontologies           About GeneDecksing



PPP4R1L Antibody Products: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR011989 ARM-like
 IPR021133 HEAT_type_2
 IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q9P1A2

ProtoNet protein and cluster: Q9P1A2

1 Blocks protein domain: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: PP4RL_HUMAN, Q9P1A2
Similarity: Contains 4 HEAT repeats


PPP4R1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PP4RL_HUMAN, Q9P1A2
Function: May be a regulatory subunit of serine/threonine-protein phosphatase 4

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005488binding ----
GO:0005515protein binding ----
     
PPP4R1L for ontologies           About GeneDecksing


Phenotypes:
     4 GenomeRNAi human phenotypes for PPP4R1L:
 Apoptosis resistance  G0/1 arrest  Increased G1 DNA content  Upregulation of NF-kappaB path 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP4R1L 
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miRNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP4R1L


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP4R1L

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

PPP4R1L for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPP4R1L (PP4RL)

Search CenterWatch for drugs/clinical trials and news about PPP4R1L / PP4RL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPP4R1L gene: 
NM_018498.2  

Unigene Cluster for PPP4R1L:

Protein phosphatase 4, regulatory subunit 1-like
Hs.473179  [show with all ESTs]
Unigene Representative Sequence: AL833409
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000497138(uc002xyw.3) ENST00000457990 ENST00000467784 ENST00000493688
ENST00000606437 ENST00000473210 ENST00000495058 ENST00000475130 ENST00000244070(uc002xyy.1)
ENST00000422302 ENST00000462333 ENST00000334187(uc010gjn.1)
miRNA
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Inhib. RNA
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Browse for Gene Knock-down Tools from EMD Millipore
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Clone
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Sirion Biotech Customized lentivirus for stable overexpression of PPP4R1L 
                     Customized lentivirus expression plasmids for stable overexpression of PPP4R1L 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP4R1L
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Additional mRNA sequence: 

AK299330.1 AL833409.1 BC100979.1 BC100980.1 NR_003505.3 

8 DOTS entries:

DT.97807532  DT.40259633  DT.70105293  DT.95203896  DT.92026381  DT.120822198  DT.120822208  DT.424297 

24/38 AceView cDNA sequences (see all 38):

CR605633 C01463 BE463655 CD654184 AK057583 AL844408 BG742094 AI478717 
AI675992 BX452457 BE245386 BU621256 AI368196 AV722049 BX422703 BM842626 
BM970884 AI281001 AI247378 AL844407 AI218093 AI125386 AL833409 AL731927 

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R1L (see all 7)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1:                    -                                                     -     -                                                                           
SP2:                                                                          -     -                                   -           -                           
SP3:                                                                                                                                                            
SP4:                                                                                                                                                            
SP5:                                                                                                                    -           -           -               

ExUns: 17c ^ 18
SP1:            
SP2:            
SP3:            
SP4:            
SP5:            


ECgene alternative splicing isoforms for PPP4R1L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP4R1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTCTCCAGGG
PPP4R1L Expression
About this image


Genevestigator expression for PPP4R1L

SOURCE GeneReport for Unigene cluster: Hs.473179
    SABiosciences Custom PCR Arrays for PPP4R1L
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP4R1L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP4R1L gene from 7/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia PPP4R1L6
protein phosphatase 4, regulatory subunit 1-like
19(a)
1 ↔ 1
24(43028155-43108032)
chicken
(Gallus gallus)
Aves PPP4R1L6
protein phosphatase 4, regulatory subunit 1-like
15(a)
1 ↔ 1
20(11575896-11593722)
lizard
(Anolis carolinensis)
Reptilia PPP4R1L6
protein phosphatase 4, regulatory subunit 1-like
15(a)
1 ↔ 1
GL343217.1(150335-210329)
tropical clawed frog
(Xenopus tropicalis)
Amphibia 1420055212   -- 77.28(n)    142005521 
zebrafish
(Danio rerio)
Actinopterygii PPP4R1L6
protein phosphatase 4, regulatory subunit 1-like
12(a)
1 ↔ 1
6(49475700-49499152)
worm
(Caenorhabditis elegans)
Secernentea ppfr-16
Protein PPFR-1, isoform d
4(a)
1 → many
I(9364175-9390093)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPD36
Regulatory subunit A of the heterotrimeric protein...
3(a)
1 → many
I(124879-126786)


ENSEMBL Gene Tree for PPP4R1L (if available)
TreeFam Gene Tree for PPP4R1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PPP4R1L gene
PPP4R12  
1 SIMAP similar gene for PPP4R1L using alignment to 6 protein entries:     PP4RL_HUMAN (see all proteins):
PPP4R1

PPP4R1L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1511 SNPs in PPP4R1L are shown (see all 1511)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1451347761,2
--53669050(+) TAAATG/TGTTTT 1 -- us2k10--------
rs5650271,2
C,F,A,H--53669090(+) CTGAAG/CCCTTA 1 -- us2k112Minor allele frequency- C:0.46NA WA CSA EA 377
rs60703891,2
F,H--56807423(+) GTTAAG/AGCTTA 1 -- ds50014Minor allele frequency- A:0.01NS EA 420
rs1897234791,2
--56807523(+) TAGCAC/TATGTT 1 -- ds50010--------
rs60152271,2
C,F,A,H--56807673(+) GGAAAA/G/TCTAGT 1 -- ds500111NS EA NA WA 1212
rs22749321,2
C,F,H--56807792(+) CCTCAC/TGTTGG 1 -- ds5001 ese323Minor allele frequency- T:0.11NS EA NA WA EU 3419
rs1140048041,2
F--56807889(+) GCCTGC/TTCCAA 1 -- nc-transcript-variant1Minor allele frequency- T:0.01WA 118
rs794262461,2
C--56807892(+) TGCTCA/CAAGAA 1 -- nc-transcript-variant0--------
rs1828941521,2
--56807921(+) GATGTC/TTTCCG 1 -- nc-transcript-variant0--------
rs38187441,2
C,F,A,H--56807969(+) AAGTCA/GTTTCA 1 -- nc-transcript-variant32Minor allele frequency- G:0.44NA NS EA WA EU 3923

HapMap Linkage Disequilibrium report for PPP4R1L (56806188 - 56884495 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PPP4R1L:    About this table     
Variant IDTypeSubtypePubMed ID
esv2722620CNV Deletion23290073

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPP4R1L for disorders           About MalaCards

PPP4R1L for disorders           About GeneDecksing

Genetic Association Database (GAD): PPP4R1L

Export disorders for PPP4R1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PPP4R1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with PPP4R1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
  2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2, 3 Deloukas P....Rogers J. (2001)
  3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
  5. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (2010)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)1 Yu Y....He F. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 55370 HGNC: 15755 AceView: PPP4R1L Ensembl:ENSG00000124224 euGenes: HUgn55370
ECgene: PPP4R1L H-InvDB: PPP4R1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PPP4R1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PPP4R1L gene:
Search GeneIP for patents involving PPP4R1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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