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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP4R1 Gene

protein-coding   GIFtS: 57
GCID: GC18M009546

Protein Phosphatase 4, Regulatory Subunit 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 4, Regulatory Subunit 11 2
PP4R12 3 5
MEG12 3
PP4(Rmeg)2
Serine/Threonine Phosphatase 42
Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 12

External Ids:    HGNC: 93201   Entrez Gene: 99892   Ensembl: ENSG000001548457   OMIM: 6049085   UniProtKB: Q8TF053   

Export aliases for PPP4R1 gene to outside databases

Previous GC identifers: GC18P009645 GC18M009603 GC18M009536 GC18M009496 GC18M009523 GC18M009510


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP4R1 Gene:
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4).
The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a
distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is
also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jun 2012)

GeneCards Summary for PPP4R1 Gene: 
PPP4R1 (protein phosphatase 4, regulatory subunit 1) is a protein-coding gene. Diseases associated with PPP4R1 include silver-russell syndrome, and schizophrenia. GO annotations related to this gene include protein phosphatase type 4 regulator activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP4R1L.

UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05
Function: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell
division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of
HDAC3

Gene Wiki entry for PPP4R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP4R1 gene promoter:
         ER-alpha   TBP   c-Fos   Pax-5   p53   AP-1   S8   TFIID   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP4R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP4R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP4R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.22   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.22

PPP4R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP4R1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M009546:  view genomic region     (about GC identifiers)

Start:
9,546,789 bp from pter      End:
9,615,238 bp from pter
Size:
68,450 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 4 regulatory subunit 1  
Size: 950 amino acids; 107004 Da
Subunit: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or
more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with HDAC3
Sequence caution: Sequence=AAD43008.1; Type=Erroneous initiation;
Secondary accessions: Q99774 Q9UNQ7
Alternative splicing: 2 isoforms:  Q8TF05-1   Q8TF05-2   

Explore the universe of human proteins at neXtProt for PPP4R1: NX_Q8TF05

Explore proteomics data for PPP4R1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF05

  • PPP4R1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP4R1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001035847.1  NP_005125.1  

    ENSEMBL proteins: 
     ENSP00000383402   ENSP00000383401   ENSP00000285124   ENSP00000462621   ENSP00000463459  
     ENSP00000462399   ENSP00000463345   ENSP00000464394   ENSP00000463909   ENSP00000462161  
     ENSP00000462485  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030289protein phosphatase 4 complex ISS--

    PPP4R1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP4R: Serine/threonine phosphatases / Protein phosphatase 4, regulatory subunits

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR000357 HEAT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8TF05

    ProtoNet protein and cluster: Q8TF05

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05
    Similarity: Contains 14 HEAT repeats


    PPP4R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP4R1_HUMAN, Q8TF05
    Function: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell
    division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of
    HDAC3

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721contributes to phosphoprotein phosphatase activity ISS--
    GO:0005488binding ----
    GO:0005515protein binding IPI16085932
    GO:0030362protein phosphatase type 4 regulator activity NAS10026142
         
    PPP4R1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP4R1:
     Increased HPV18 LCR reporter a  Increased apoptosis 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP4R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for PPP4R1 (Q8TF051, 3 ENSP000003834024) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP4CP605101, 3, ENSP000002793874EBI-1056262,EBI-1046072 I2D: score=3 STRING: ENSP00000279387
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    HDAC3O153793, ENSP000003029674I2D: score=3 STRING: ENSP00000302967
    CEP63Q96MT83, ENSP000003365244I2D: score=1 STRING: ENSP00000336524
    CNEP1R1ENSP000004056354STRING: ENSP00000405635
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007165signal transduction NAS10026142

    PPP4R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP4R1 (PP4R1)

    Search CenterWatch for drugs/clinical trials and news about PPP4R1 / PP4R1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP4R1 gene (2 alternative transcripts): 
    NM_001042388.2  NM_005134.3  

    Unigene Cluster for PPP4R1:

    Protein phosphatase 4, regulatory subunit 1
    Hs.743236  [show with all ESTs]
    Unigene Representative Sequence: NM_001042388
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000400556(uc010wzo.1 uc002koe.1) ENST00000400555(uc002kof.2 uc002kod.1)
    ENST00000582594 ENST00000285124(uc010wzp.1) ENST00000579609 ENST00000578329
    ENST00000578010 ENST00000584754 ENST00000577667 ENST00000583438 ENST00000583988
    ENST00000578557 ENST00000580583 ENST00000578875 ENST00000578178 ENST00000579638
    ENST00000583903 ENST00000584074
    miRNA
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    Additional mRNA sequence: 

    AF100744.1 AF200478.1 AK025509.1 AK027064.1 AK292538.1 AK293869.1 AK295533.1 AK315106.1 
    AY486333.1 BC060829.1 NR_052003.1 U79267.1 

    24/28 DOTS entries (see all 28):

    DT.95345282  DT.454443  DT.95345292  DT.92441060  DT.101982832  DT.95345288  DT.91755259  DT.100789819 
    DT.100789820  DT.443619  DT.92441066  DT.95303427  DT.99978469  DT.121106670  DT.121106582  DT.92441068 
    DT.95257260  DT.100029735  DT.121106609  DT.121106617  DT.121106632  DT.121106672  DT.75179081  DT.95345281 

    24/368 AceView cDNA sequences (see all 368):

    BP357843 BQ424497 AW270022 F04772 BU629525 BU902154 BU553393 AA860292 
    BM977802 BI259201 CN481544 BQ185797 CA313481 BG681873 AA492553 AA936114 
    BM743940 BM973924 AI445422 BU541089 AI559964 F10765 BM661702 AF200478 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R1 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -           -           -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b · 21c
    SP1:              -     -                                                               
    SP2:              -     -                       -     -                                 
    SP3:              -     -                       -     -                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for PPP4R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP4R1 expression in normal human tissues (normalized intensities)      PPP4R1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTTAAAC
    PPP4R1 Expression
    About this image


    PPP4R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells

    See PPP4R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP4R1

    SOURCE GeneReport for Unigene cluster: Hs.743236

    UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05
    Tissue specificity: Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are
    expressed in renal tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPP4R1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp4r11 , 5 protein phosphatase 4, regulatory subunit 11, 5 84.65(n)1
    87.14(a)1
      17 (35.26 cM)5
    703511  NM_146081.21  NP_666193.21 
     657825735 
    chicken
    (Gallus gallus)
    Aves PPP4R11 protein phosphatase 4, regulatory subunit 1 77.66(n)
    81.62(a)
      425903  XM_423594.3  XP_423594.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPP4R16
    protein phosphatase 4, regulatory subunit 1
    78(a)
    1 ↔ 1
    GL343319.1(620626-660449)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83242 Xenopus laevis, Similar to protein phosphatase 4, regulatory more 78.93(n)    BC046255.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556032 similar to protein phosphatase 4, regulatory subunit more 71.81(n)   393230  BC048878.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M04C9.6a3
    ppfr-11
    protein phosphatase regulatory subunit
    like3
    Protein PPFR-11
    30(a)
    (best of 2)3
    43.73(n)1
    32.8(a)1
      I(9372834-9380223)3
    1727611  NM_001128984.11  NP_001122456.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPD36
    Regulatory subunit A of the heterotrimeric protein...
    17(a)
    1 → many
    I(124879-126786)


    ENSEMBL Gene Tree for PPP4R1 (if available)
    TreeFam Gene Tree for PPP4R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP4R1 gene
    PPP4R1L2  
    1 SIMAP similar gene for PPP4R1 using alignment to 10 protein entries:     PP4R1_HUMAN (see all proteins):
    PPP4R1L

    PPP4R1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1490 SNPs in PPP4R1 are shown (see all 1490)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766398431,2
    C,F--9546333(+) GTTCAA/GAGGAA 3 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1470824261,2
    --9546409(+) CAGGGA/GACTCC 3 -- ds50010--------
    rs1383461641,2
    --9546538(+) CAGGGC/TAGGTT 3 -- ds50010--------
    rs1496376281,2
    --9546572(+) GAAGAA/CATCGA 3 -- ds50010--------
    rs1914077731,2
    --9546595(+) CTTGAC/GTGTGT 3 -- ds50010--------
    rs1173465721,2
    C,F--9546677(+) CACCCA/CCCTGC 3 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1833203371,2
    --9546732(+) CTGCTC/GCTGCC 3 -- ds50010--------
    rs1434697421,2
    C--9546898(+) TGTATA/GTATCT 3 -- ut31 nc-transcript-variant0--------
    rs770620961,2
    C--9546900(+) TATATA/CTCTCT 3 -- ut31 nc-transcript-variant0--------
    rs115584511,2
    C--9546999(+) CCAAGA/GGTGGT 3 -- ut31 nc-transcript-variantese32Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for PPP4R1 (9546789 - 9615238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP4R1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509683CNV Insertion20534489
    esv29650CNV Loss19812545
    nsv458024CNV Gain19166990
    nsv833585CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604908    OMIM disorders: --

    2 diseases for PPP4R1:    About MalaCards
    silver-russell syndrome    schizophrenia


    PPP4R1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP4R1
    Human Genome Epidemiology (HuGE) Navigator: PPP4R1 (2 documents)

    Export disorders for PPP4R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP4R1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with PPP4R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. (PubMed id 10026142)1, 2, 3, 9 Kloeker S. and Wadzinski B.E. (1999)
    2. Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. (PubMed id 11729228)1, 2, 9 Wada T.... Kurokawa K. (2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. (PubMed id 15805470)1, 2 Zhang X....Seto E. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (1997)
    7. A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes. (PubMed id 23084358)1 Brechmann M....Arnold R. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9989 HGNC: 9320 AceView: PPP4R1 Ensembl:ENSG00000154845 euGenes: HUgn9989
    ECgene: PPP4R1 H-InvDB: PPP4R1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP4R1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP4R1 gene:
    Search GeneIP for patents involving PPP4R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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