Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP4R1 Gene

Aliases for PPP4R1 Gene

  • Protein Phosphatase 4, Regulatory Subunit 1 2 3
  • PP4R1 3 4 6
  • MEG1 3 4
  • Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1 3
  • Serine/Threonine Phosphatase 4 3
  • PP4(Rmeg) 3

External Ids for PPP4R1 Gene

Previous GeneCards Identifiers for PPP4R1 Gene

  • GC18P009645
  • GC18M009603
  • GC18M009536
  • GC18M009496
  • GC18M009523
  • GC18M009510

Summaries for PPP4R1 Gene

Entrez Gene Summary for PPP4R1 Gene

  • This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for PPP4R1 Gene

PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1) is a Protein Coding gene. GO annotations related to this gene include phosphoprotein phosphatase activity and protein phosphatase type 4 regulator activity.

UniProtKB/Swiss-Prot for PPP4R1 Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.

Gene Wiki entry for PPP4R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4R1 Gene

Genomics for PPP4R1 Gene

Regulatory Elements for PPP4R1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP4R1 Gene

Start:
9,546,791 bp from pter
End:
9,615,240 bp from pter
Size:
68,450 bases
Orientation:
Minus strand

Genomic View for PPP4R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP4R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4R1 Gene

Proteins for PPP4R1 Gene

  • Protein details for PPP4R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF05-PP4R1_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 1
    Protein Accession:
    Q8TF05
    Secondary Accessions:
    • Q99774
    • Q9UNQ7

    Protein attributes for PPP4R1 Gene

    Size:
    950 amino acids
    Molecular mass:
    107004 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with HDAC3.
    SequenceCaution:
    • Sequence=AAD43008.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP4R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP4R1 Gene

Proteomics data for PPP4R1 Gene at MOPED

Post-translational modifications for PPP4R1 Gene

  • Ubiquitination at Lys643, Lys730, and Lys803
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP4R1 Gene

Domains for PPP4R1 Gene

Gene Families for PPP4R1 Gene

HGNC:
  • PPP4R :Serine/threonine phosphatases / Protein phosphatase 4, regulatory subunits

Protein Domains for PPP4R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF05

UniProtKB/Swiss-Prot:

PP4R1_HUMAN :
  • Q8TF05
Similarity:
  • Contains 14 HEAT repeats.
genes like me logo Genes that share domains with PPP4R1: view

Function for PPP4R1 Gene

Molecular function for PPP4R1 Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.

Gene Ontology (GO) - Molecular Function for PPP4R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 contributes_to phosphoprotein phosphatase activity ISS --
GO:0005488 binding --
GO:0005515 protein binding IPI 16085932
GO:0030362 protein phosphatase type 4 regulator activity NAS 10026142
genes like me logo Genes that share ontologies with PPP4R1: view

Phenotypes for PPP4R1 Gene

GenomeRNAi human phenotypes for PPP4R1:
genes like me logo Genes that share phenotypes with PPP4R1: view

Animal Model Products

CRISPR Products

miRNA for PPP4R1 Gene

miRTarBase miRNAs that target PPP4R1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP4R1 Gene

Localization for PPP4R1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP4R1 Gene COMPARTMENTS Subcellular localization image for PPP4R1 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP4R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030289 protein phosphatase 4 complex ISS --
genes like me logo Genes that share ontologies with PPP4R1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP4R1 Gene

Pathways for PPP4R1 Gene

SuperPathways for PPP4R1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP4R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007165 signal transduction NAS 10026142
GO:0016311 dephosphorylation ISS --
GO:0050790 regulation of catalytic activity NAS 10026142
genes like me logo Genes that share ontologies with PPP4R1: view

No data available for Pathways by source for PPP4R1 Gene

Transcripts for PPP4R1 Gene

Unigene Clusters for PPP4R1 Gene

Protein phosphatase 4, regulatory subunit 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP4R1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: -
SP2:
SP3:
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14: - -
SP15:

ExUns: 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b · 21c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10: - - - - - -
SP11: - -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PPP4R1 Gene

GeneLoc Exon Structure for
PPP4R1
ECgene alternative splicing isoforms for
PPP4R1

Expression for PPP4R1 Gene

mRNA expression in normal human tissues for PPP4R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP4R1 Gene

SOURCE GeneReport for Unigene cluster for PPP4R1 Gene Hs.743236

mRNA Expression by UniProt/SwissProt for PPP4R1 Gene

Q8TF05-PP4R1_HUMAN
Tissue specificity: Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.
genes like me logo Genes that share expressions with PPP4R1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP4R1 Gene

Orthologs for PPP4R1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP4R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP4R1 35
  • 99.64 (n)
  • 99.57 (a)
PPP4R1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP4R1 35
  • 79.05 (n)
  • 85.86 (a)
PPP4R1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP4R1 35
  • 90.01 (n)
  • 92.27 (a)
PPP4R1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp4r1 35
  • 84.62 (n)
  • 87.14 (a)
Ppp4r1 16
Ppp4r1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP4R1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP4R1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp4r1 35
  • 83.77 (n)
  • 87.09 (a)
chicken
(Gallus gallus)
Aves PPP4R1 35
  • 77.57 (n)
  • 81.43 (a)
PPP4R1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP4R1 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8324 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp4r1 35
  • 72.2 (n)
  • 77.71 (a)
Str.6036 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13164 35
zebrafish
(Danio rerio)
Actinopterygii ppp4r1 35
  • 62.61 (n)
  • 68.13 (a)
ppp4r1 36
  • 43 (a)
OneToMany
PPP4R1 (2 of 2) 36
  • 61 (a)
OneToMany
zgc55603 35
worm
(Caenorhabditis elegans)
Secernentea ppfr-1 36
  • 15 (a)
OneToMany
M04C9.6a 37
  • 30 (a)
M04C9.6b 37
  • 30 (a)
Species with no ortholog for PPP4R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP4R1 Gene

ENSEMBL:
Gene Tree for PPP4R1 (if available)
TreeFam:
Gene Tree for PPP4R1 (if available)

Paralogs for PPP4R1 Gene

Selected SIMAP similar genes for PPP4R1 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with PPP4R1: view

No data available for Paralogs for PPP4R1 Gene

Variants for PPP4R1 Gene

Sequence variations from dbSNP and Humsavar for PPP4R1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs15246 -- 9,547,083(-) CGTAT(A/T)ATGTA utr-variant-3-prime, nc-transcript-variant
rs329000 -- 9,577,354(-) TTTCA(A/G)TCCTA intron-variant
rs329001 -- 9,569,271(-) TAAAT(G/T)TTATT intron-variant
rs329002 -- 9,569,367(-) cGGGC(A/G)TGGGG intron-variant
rs329003 - 9,570,322(-) TAGAC(A/G)TAGAG reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4R1 Gene

Variant ID Type Subtype PubMed ID
nsv833585 CNV Gain+Loss 17160897
nsv458024 CNV Gain 19166990
nsv509683 CNV Insertion 20534489
esv29650 CNV Loss 19812545

Relevant External Links for PPP4R1 Gene

HapMap Linkage Disequilibrium report
PPP4R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R1 Gene

Disorders for PPP4R1 Gene

Relevant External Links for PPP4R1

Genetic Association Database (GAD)
PPP4R1
Human Genome Epidemiology (HuGE) Navigator
PPP4R1
genes like me logo Genes that share disorders with PPP4R1: view

No data available for UniProtKB/Swiss-Prot for PPP4R1 Gene

Publications for PPP4R1 Gene

  1. Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. (PMID: 10026142) Kloeker S. … Wadzinski B.E. (J. Biol. Chem. 1999) 2 3 4 23
  2. Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. (PMID: 11729228) Wada T. … Kurokawa K. (J. Am. Soc. Nephrol. 2001) 3 4 23
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. (PMID: 15805470) Zhang X. … Seto E. (Genes Dev. 2005) 3 4

Products for PPP4R1 Gene

  • antibodies-online proteins for PPP4R1
  • antibodies-online antibodies for PPP4R1
  • antibodies-online kits for PPP4R1

Sources for PPP4R1 Gene

Back to Top

Content