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PPP4R1 Gene

protein-coding   GIFtS: 55
GCID: GC18M009546

Protein Phosphatase 4, Regulatory Subunit 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 4, Regulatory Subunit 11 2
PP4R12 3 5
MEG12 3
PP4(Rmeg)2
Serine/Threonine Phosphatase 42
Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 12

External Ids:    HGNC: 93201   Entrez Gene: 99892   Ensembl: ENSG000001548457   OMIM: 6049085   UniProtKB: Q8TF053   

Export aliases for PPP4R1 gene to outside databases

Previous GC identifers: GC18P009645 GC18M009603 GC18M009536 GC18M009496 GC18M009523 GC18M009510


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP4R1 Gene:
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4).
The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a
distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is
also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jun 2012)

GeneCards Summary for PPP4R1 Gene:
PPP4R1 (protein phosphatase 4, regulatory subunit 1) is a protein-coding gene. GO annotations related to this gene include protein phosphatase type 4 regulator activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP4R1L.

UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05
Function: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell
division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of
HDAC3

Gene Wiki entry for PPP4R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PPP4R1 gene promoter:
         ER-alpha   TBP   c-Fos   Pax-5   p53   AP-1   S8   TFIID   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP4R1 promoter sequence
   Search Chromatin IP Primers for PPP4R1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP4R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.22   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.22

PPP4R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP4R1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M009546:  view genomic region     (about GC identifiers)

Start:
9,546,789 bp from pter      End:
9,615,238 bp from pter
Size:
68,450 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 4 regulatory subunit 1  
Size: 950 amino acids; 107004 Da
Subunit: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or
more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with HDAC3
Sequence caution: Sequence=AAD43008.1; Type=Erroneous initiation;
Secondary accessions: Q99774 Q9UNQ7
Alternative splicing: 2 isoforms:  Q8TF05-1   Q8TF05-2   

Explore the universe of human proteins at neXtProt for PPP4R1: NX_Q8TF05

Explore proteomics data for PPP4R1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys643, Lys730, Lys803
  • Modification sites at PhosphoSitePlus

  • See PPP4R1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035847.1  NP_005125.1  

    ENSEMBL proteins: 
     ENSP00000383402   ENSP00000383401   ENSP00000285124   ENSP00000462621   ENSP00000463459  
     ENSP00000462399   ENSP00000463345   ENSP00000464394   ENSP00000463909   ENSP00000462161  
     ENSP00000462485  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP4R: Serine/threonine phosphatases / Protein phosphatase 4, regulatory subunits

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR000357 HEAT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8TF05

    ProtoNet protein and cluster: Q8TF05

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05
    Similarity: Contains 14 HEAT repeats


    Find genes that share domains with PPP4R1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP4R1_HUMAN, Q8TF05
    Function: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell
    division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of
    HDAC3

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721contributes to phosphoprotein phosphatase activity ISS--
    GO:0005488binding ----
    GO:0005515protein binding IPI16085932
    GO:0030362protein phosphatase type 4 regulator activity NAS10026142
         
    Find genes that share ontologies with PPP4R1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP4R1:
     Increased HPV18 LCR reporter a  Increased apoptosis 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PPP4R1

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    miRTarBase miRNAs that target PPP4R1:
    hsa-mir-149-5p (MIRT045435), hsa-mir-101-3p (MIRT027240)

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    Selected qRT-PCR Assays for microRNAs that regulate PPP4R1 (see all 17):
    hsa-miR-330-5p hsa-miR-4251 hsa-miR-539 hsa-miR-3942-5p hsa-miR-3921 hsa-miR-1297 hsa-miR-326 hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidPPP4R1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030289protein phosphatase 4 complex ISS--

    Find genes that share ontologies with PPP4R1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP4R1
    Interactions:

        Search GeneGlobe Interaction Network for PPP4R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP4R1 (Q8TF051, 3 ENSP000003834024) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP4CP605101, 3, ENSP000002793874EBI-1056262,EBI-1046072 I2D: score=3 STRING: ENSP00000279387
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    HDAC3O153793, ENSP000003029674I2D: score=3 STRING: ENSP00000302967
    CEP63Q96MT83, ENSP000003365244I2D: score=1 STRING: ENSP00000336524
    CNEP1R1ENSP000004056354STRING: ENSP00000405635
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007165signal transduction NAS10026142
    GO:0016311dephosphorylation ISS--
    GO:0050790regulation of catalytic activity NAS10026142

    Find genes that share ontologies with PPP4R1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PPP4R1 (PP4R1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP4R1 gene (2 alternative transcripts): 
    NM_001042388.2  NM_005134.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000400556(uc010wzo.1 uc002koe.1) ENST00000400555(uc002kof.2 uc002kod.1)
    ENST00000582594 ENST00000285124(uc010wzp.1) ENST00000579609 ENST00000578329
    ENST00000578010 ENST00000584754 ENST00000577667 ENST00000583438 ENST00000583988
    ENST00000578557 ENST00000580583 ENST00000578875 ENST00000578178 ENST00000579638
    ENST00000583903 ENST00000584074
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    Selected qRT-PCR Assays for microRNAs that regulate PPP4R1 (see all 17):
    hsa-miR-330-5p hsa-miR-4251 hsa-miR-539 hsa-miR-3942-5p hsa-miR-3921 hsa-miR-1297 hsa-miR-326 hsa-miR-26b
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP4R1
      QuantiFast Probe-based Assays in human, mouse, rat PPP4R1

    Selected AceView cDNA sequences (see all 368):

    BQ009395 BF913961 AW296720 AA936114 CA313481 BM743940 AW467646 AA805421 
    AF200478 BM712078 BU607455 AA693651 AI445422 BQ930694 BG696342 AI139064 
    BU902154 BQ939274 CN481544 AX746589 BU629525 AI131196 BC060829 AA732402 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP4R1 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -           -           -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b · 21c
    SP1:              -     -                                                               
    SP2:              -     -                       -     -                                 
    SP3:              -     -                       -     -                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for PPP4R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP4R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTTAAAC
    PPP4R1 Expression
    About this image


    PPP4R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Esophagus (Gastrointestinal Tract)
    PPP4R1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP4R1 Protein Expression

    UniProtKB/Swiss-Prot: PP4R1_HUMAN, Q8TF05
    Tissue specificity: Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are
    expressed in renal tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP4R1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPP4R1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp4r11 , 5 protein phosphatase 4, regulatory subunit 11, 5 84.62(n)1
    87.14(a)1
      17 (35.26 cM)5
    703511  NM_146081.21  NP_666193.21 
     657825735 
    chicken
    (Gallus gallus)
    Aves PPP4R11 protein phosphatase 4, regulatory subunit 1 77.57(n)
    81.43(a)
      425903  XM_004939730.1  XP_004939787.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP4R16
    protein phosphatase 4, regulatory subunit 1
    77(a)
    1 ↔ 1
    GL343319.1(620626-660449)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83242 Xenopus laevis, Similar to protein phosphatase 4, regulatory more 78.93(n)    BC046255.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556032 similar to protein phosphatase 4, regulatory subunit more 71.81(n)   393230  BC048878.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M04C9.6a3 protein phosphatase regulatory subunit
    like
    30(a)
    (best of 2)
      I(9372834-9380223)   --


    ENSEMBL Gene Tree for PPP4R1 (if available)
    TreeFam Gene Tree for PPP4R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP4R1 gene
    PPP4R1L2  
    1 SIMAP similar gene for PPP4R1 using alignment to 10 protein entries:     PP4R1_HUMAN (see all proteins):
    PPP4R1L

    Find genes that share paralogs with PPP4R1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP4R1 (see all 1490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766398431,2
    C,F--9546333(+) GTTCAA/GAGGAA 3 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1470824261,2
    --9546409(+) CAGGGA/GACTCC 3 -- ds50010--------
    rs1383461641,2
    --9546538(+) CAGGGC/TAGGTT 3 -- ds50010--------
    rs1496376281,2
    --9546572(+) GAAGAA/CATCGA 3 -- ds50010--------
    rs1914077731,2
    --9546595(+) CTTGAC/GTGTGT 3 -- ds50010--------
    rs1173465721,2
    C,F--9546677(+) CACCCA/CCCTGC 3 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1833203371,2
    --9546732(+) CTGCTC/GCTGCC 3 -- ds50010--------
    rs1434697421,2
    C--9546898(+) TGTATA/GTATCT 3 -- ut31 nc-transcript-variant0--------
    rs770620961,2
    C--9546900(+) TATATA/CTCTCT 3 -- ut31 nc-transcript-variant0--------
    rs115584511,2
    C--9546999(+) CCAAGA/GGTGGT 3 -- ut31 nc-transcript-variantese32Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for PPP4R1 (9546789 - 9615238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP4R1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509683CNV Insertion20534489
    esv29650CNV Loss19812545
    nsv458024CNV Gain19166990
    nsv833585CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604908    OMIM disorders: --


    Find genes that share disorders with PPP4R1           About GenesLikeMe

    Genetic Association Database (GAD): PPP4R1
    Human Genome Epidemiology (HuGE) Navigator: PPP4R1 (2 documents)

    Export disorders for PPP4R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP4R1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with PPP4R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. (PubMed id 10026142)1, 2, 3, 9 Kloeker S. and Wadzinski B.E. (J. Biol. Chem. 1999)
    2. Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. (PubMed id 11729228)1, 2, 9 Wada T.... Kurokawa K. (J. Am. Soc. Nephrol. 2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. (PubMed id 15805470)1, 2 Zhang X....Seto E. (Genes Dev. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (Genome Res. 1997)
    7. A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes. (PubMed id 23084358)1 Brechmann M....Arnold R. (Immunity 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9989 HGNC: 9320 AceView: PPP4R1 Ensembl:ENSG00000154845 euGenes: HUgn9989
    ECgene: PPP4R1 H-InvDB: PPP4R1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP4R1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP4R1 gene:
    Search GeneIP for patents involving PPP4R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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