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Aliases for PPP4C Gene

Aliases for PPP4C Gene

  • Protein Phosphatase 4 Catalytic Subunit 2 3 5
  • Protein Phosphatase 4 (Formerly X), Catalytic Subunit 2 3
  • Protein Phosphatase X, Catalytic Subunit 2 3
  • EC 3.1.3.16 4 58
  • PP-X 3 4
  • PP4C 3 4
  • PPP4 3 4
  • PP4 3 4
  • PPX 3 4
  • Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit 3
  • Protein Phosphatase 4, Catalytic Subunit 2
  • Protein Phosphatase X 4
  • PPH3 3

External Ids for PPP4C Gene

Previous GeneCards Identifiers for PPP4C Gene

  • GC16M029064
  • GC16P030409
  • GC16P030085
  • GC16P030126
  • GC16P030114
  • GC16P029994
  • GC16P027748

Summaries for PPP4C Gene

GeneCards Summary for PPP4C Gene

PPP4C (Protein Phosphatase 4 Catalytic Subunit) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Glucagon signaling pathway. GO annotations related to this gene include hydrolase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2CA.

UniProtKB/Swiss-Prot for PPP4C Gene

  • Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Gene Wiki entry for PPP4C Gene

Additional gene information for PPP4C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4C Gene

Genomics for PPP4C Gene

Regulatory Elements for PPP4C Gene


Enhancers around PPP4C on UCSC Golden Path with GeneCards custom track

Promoters for PPP4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085148 224 1601 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 ZHX2 REST ZNF592

Genomic Location for PPP4C Gene

Chromosome:
16
Start:
30,075,976 bp from pter
End:
30,085,377 bp from pter
Size:
9,402 bases
Orientation:
Plus strand

Genomic View for PPP4C Gene

Genes around PPP4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4C Gene

Proteins for PPP4C Gene

  • Protein details for PPP4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60510-PP4C_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit
    Protein Accession:
    P60510
    Secondary Accessions:
    • P33172

    Protein attributes for PPP4C Gene

    Size:
    307 amino acids
    Molecular mass:
    35080 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.

neXtProt entry for PPP4C Gene

Selected DME Specific Peptides for PPP4C Gene

P60510:
  • GDFVDRG
  • DLLWSDP
  • YGFYDEC
  • RAHQLVMEG
  • IRTIDRK
  • SAPNYCYRC
  • NYLFMGD
  • LLLALKV
  • RKYGSVTVW
  • IFEAAPQE
  • RGNHESRQ
  • LIRGNHE
  • RGIPSKKP
  • CGDIHGQ
  • AIIDGKI
  • TGWGVSPRGAGYLFGSDVV
  • HGQFYDL
  • DRQIEQL
  • IDRKQEVPH
  • CVHGGLSP
  • CTEIFDYLSL
  • ELFRVGG

Post-translational modifications for PPP4C Gene

  • Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
  • Ubiquitination at posLast=2626, Lys63, and Lys183
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PPP4C
  • Santa Cruz Biotechnology (SCBT) Antibodies for PPP4C

Domains & Families for PPP4C Gene

Gene Families for PPP4C Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PPP4C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60510

UniProtKB/Swiss-Prot:

PP4C_HUMAN :
  • Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
genes like me logo Genes that share domains with PPP4C: view

Function for PPP4C Gene

Molecular function for PPP4C Gene

GENATLAS Biochemistry:
serine/threonine protein phosphatase 4C,catalytic subunit,35kDa,putatively involved in mitosis regulation
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Enzyme Numbers (IUBMB) for PPP4C Gene

Phenotypes From GWAS Catalog for PPP4C Gene

Gene Ontology (GO) - Molecular Function for PPP4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004704 NF-kappaB-inducing kinase activity NAS 9837938
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity NAS 9837938
GO:0005515 protein binding IPI 9647778
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP4C: view
genes like me logo Genes that share phenotypes with PPP4C: view

Animal Models for PPP4C Gene

MGI Knock Outs for PPP4C:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP4C

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPP4C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP4C Gene

Localization for PPP4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP4C Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP4C gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PPP4C: view

Pathways & Interactions for PPP4C Gene

genes like me logo Genes that share pathways with PPP4C: view

SIGNOR curated interactions for PPP4C Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0010569 regulation of double-strand break repair via homologous recombination IMP 20154705
GO:0038061 NIK/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with PPP4C: view

Drugs & Compounds for PPP4C Gene

(9) Drugs for PPP4C Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 35
Fostriecin sodium salt Pharma Antitumor antibiotic 0
calcium Nutra 0

(4) Additional Compounds for PPP4C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(1) ApexBio Compounds for PPP4C Gene

Compound Action Cas Number
Fostriecin sodium salt Antitumor antibiotic 87860-39-7
genes like me logo Genes that share compounds with PPP4C: view

Drug Products

Transcripts for PPP4C Gene

Unigene Clusters for PPP4C Gene

Protein phosphatase 4, catalytic subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPP4C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4C Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - -
SP14: -
SP15: - -
SP16: - - -

Relevant External Links for PPP4C Gene

GeneLoc Exon Structure for
PPP4C
ECgene alternative splicing isoforms for
PPP4C

Expression for PPP4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP4C Gene

mRNA differential expression in normal tissues according to GTEx for PPP4C Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for PPP4C Gene

This gene is overexpressed in Nasal epithelium (13.0) and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP4C Gene



Protein tissue co-expression partners for PPP4C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP4C Gene:

PPP4C

SOURCE GeneReport for Unigene cluster for PPP4C Gene:

Hs.534338

Evidence on tissue expression from TISSUES for PPP4C Gene

  • Nervous system(3.9)
  • Pancreas(2.9)
  • Skin(2.4)
  • Blood(2.1)
  • Liver(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with PPP4C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP4C Gene

Orthologs for PPP4C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP4C Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PPP4C 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP4C 33 34
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia PPP4C 33 34
  • 94.03 (n)
dog
(Canis familiaris)
Mammalia PPP4C 33 34
  • 93.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP4C 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp4c 33
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia Ppp4c 33 16 34
  • 90.55 (n)
lizard
(Anolis carolinensis)
Reptilia PPP4C 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp4c 33
  • 82.95 (n)
MGC75928 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7081 33
zebrafish
(Danio rerio)
Actinopterygii ppp4ca 34
  • 94 (a)
OneToMany
ppp4cb 33 34
  • 80.24 (n)
wufd05e08 33
fruit fly
(Drosophila melanogaster)
Insecta Pp4-19C 35 33 34
  • 80.67 (n)
CG11597 35
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003779 33
  • 77.96 (n)
worm
(Caenorhabditis elegans)
Secernentea pph-4.2 35 34
  • 72 (a)
pph-4.1 35 33 34
  • 69.09 (n)
C34C12.3 35
  • 54 (a)
C06A1.3 35
  • 43 (a)
W03D8.2 35
  • 41 (a)
F58G1.3 35
  • 40 (a)
Y40H4A.2 35
  • 37 (a)
F42G8.8 35
  • 35 (a)
C27B7.6 35
  • 32 (a)
F49E11.7 35
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR136W 33
  • 64.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10055g 33
  • 57.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH3 33
  • 55.26 (n)
PPH21 34
  • 50 (a)
ManyToMany
PPH22 34
  • 48 (a)
ManyToMany
PPG1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PPX2 33
  • 69.41 (n)
soybean
(Glycine max)
eudicotyledons Gma.5783 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1970 33
rice
(Oryza sativa)
Liliopsida Os09g0284200 33
  • 71.18 (n)
Os.17604 33
wheat
(Triticum aestivum)
Liliopsida Ta.12768 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10368 34
  • 89 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08301 33
  • 63.81 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC26H8.05c 33
  • 60.49 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11282 33
Species where no ortholog for PPP4C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP4C Gene

ENSEMBL:
Gene Tree for PPP4C (if available)
TreeFam:
Gene Tree for PPP4C (if available)

Paralogs for PPP4C Gene

Paralogs for PPP4C Gene

genes like me logo Genes that share paralogs with PPP4C: view

Variants for PPP4C Gene

Sequence variations from dbSNP and Humsavar for PPP4C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000377194 -- 30,081,430(+) CTCAC(C/T)TTCAA intron-variant
rs1000482241 -- 30,076,491(+) TGGCC(C/T)TGGGG intron-variant
rs1000492029 -- 30,076,058(+) GAGGC(A/G)GGGAG upstream-variant-2KB, utr-variant-5-prime
rs1000753260 -- 30,081,630(+) CCCAG(C/T)TACTT intron-variant
rs1000940636 -- 30,084,236(+) ATCAC(A/G)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4C Gene

Variant ID Type Subtype PubMed ID
esv2758642 CNV gain 17122850
nsv1160384 CNV duplication 26073780
nsv479615 CNV novel sequence insertion 20440878
nsv833187 CNV loss 17160897

Variation tolerance for PPP4C Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP4C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4C Gene

Disorders for PPP4C Gene

Relevant External Links for PPP4C

Genetic Association Database (GAD)
PPP4C
Human Genome Epidemiology (HuGE) Navigator
PPP4C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP4C

No disorders were found for PPP4C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP4C Gene

Publications for PPP4C Gene

  1. A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. (PMID: 20154705) Lee DH … Chowdhury D (Nature structural & molecular biology 2010) 3 4 22 60
  2. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. (PMID: 18487071) Martin-Granados C … Cohen PT (The international journal of biochemistry & cell biology 2008) 3 4 22 60
  3. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. (PMID: 18715871) Chen GI … Gingras AC (The Journal of biological chemistry 2008) 3 4 22 60
  4. PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. (PMID: 18758438) Nakada S … Durocher D (EMBO reports 2008) 3 4 22 60
  5. Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. (PMID: 18347064) Toyo-oka K … Hirotsune S (The Journal of cell biology 2008) 3 4 22 60

Products for PPP4C Gene

Sources for PPP4C Gene

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