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Aliases for PPP4C Gene

Aliases for PPP4C Gene

  • Protein Phosphatase 4, Catalytic Subunit 2 3
  • Protein Phosphatase 4 (Formerly X), Catalytic Subunit 2 3
  • Protein Phosphatase X 2 4
  • EC 3.1.3.16 4 63
  • PP-X 3 4
  • PP4C 3 4
  • PPP4 3 4
  • PP4 3 4
  • PPX 3 4
  • Protein Phosphatase X, Catalytic Subunit 3
  • Catalytic Subunit 2
  • PPH3 3

External Ids for PPP4C Gene

Previous GeneCards Identifiers for PPP4C Gene

  • GC16M029064
  • GC16P030409
  • GC16P030085
  • GC16P030126
  • GC16P030114
  • GC16P029994
  • GC16P027748

Summaries for PPP4C Gene

GeneCards Summary for PPP4C Gene

PPP4C (Protein Phosphatase 4, Catalytic Subunit) is a Protein Coding gene. Diseases associated with PPP4C include lipodystrophy, congenital generalized, type 3 and pulmonary hypertension, primary, 3. Among its related pathways are DNA Double-Strand Break Repair and Glucagon signaling pathway. GO annotations related to this gene include hydrolase activity and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2CB.

UniProtKB/Swiss-Prot for PPP4C Gene

  • Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Gene Wiki entry for PPP4C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP4C Gene

Genomics for PPP4C Gene

Regulatory Elements for PPP4C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP4C Gene

Chromosome:
16
Start:
30,075,976 bp from pter
End:
30,085,377 bp from pter
Size:
9,402 bases
Orientation:
Plus strand

Genomic View for PPP4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP4C Gene

Proteins for PPP4C Gene

  • Protein details for PPP4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60510-PP4C_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit
    Protein Accession:
    P60510
    Secondary Accessions:
    • P33172

    Protein attributes for PPP4C Gene

    Size:
    307 amino acids
    Molecular mass:
    35080 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.

neXtProt entry for PPP4C Gene

Proteomics data for PPP4C Gene at MOPED

Post-translational modifications for PPP4C Gene

  • Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
  • Ubiquitination at Lys 26, Lys 63, and Lys 183
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PPP4C Gene

Gene Families for PPP4C Gene

Suggested Antigen Peptide Sequences for PPP4C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60510

UniProtKB/Swiss-Prot:

PP4C_HUMAN :
  • Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
genes like me logo Genes that share domains with PPP4C: view

Function for PPP4C Gene

Molecular function for PPP4C Gene

GENATLAS Biochemistry:
serine/threonine protein phosphatase 4C,catalytic subunit,35kDa,putatively involved in mitosis regulation
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Enzyme Numbers (IUBMB) for PPP4C Gene

Gene Ontology (GO) - Molecular Function for PPP4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004704 NF-kappaB-inducing kinase activity NAS 9837938
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity NAS 9837938
GO:0005515 protein binding IPI 9647778
GO:0005521 lamin binding IEA --
genes like me logo Genes that share ontologies with PPP4C: view
genes like me logo Genes that share phenotypes with PPP4C: view

Animal Models for PPP4C Gene

MGI Knock Outs for PPP4C:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targets and HOMER Transcription for PPP4C Gene

Localization for PPP4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP4C Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP4C Gene COMPARTMENTS Subcellular localization image for PPP4C gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PPP4C: view

Pathways & Interactions for PPP4C Gene

genes like me logo Genes that share pathways with PPP4C: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PPP4C Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006281 DNA repair TAS --
GO:0006302 double-strand break repair TAS --
GO:0006470 protein dephosphorylation NAS 9837938
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with PPP4C: view

Drugs & Compounds for PPP4C Gene

(6) Drugs for PPP4C Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
okadaic acid Experimental Pharma 0
Manganese Pharma 30
Calcium Nutra 0
Cantharidin Pharma 7
serine Nutra 420

(6) Additional Compounds for PPP4C Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
fostriecin
genes like me logo Genes that share compounds with PPP4C: view

Transcripts for PPP4C Gene

Unigene Clusters for PPP4C Gene

Protein phosphatase 4, catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP4C Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - -
SP14: -
SP15: - -
SP16: - - -

Relevant External Links for PPP4C Gene

GeneLoc Exon Structure for
PPP4C
ECgene alternative splicing isoforms for
PPP4C

Expression for PPP4C Gene

mRNA expression in normal human tissues for PPP4C Gene

mRNA differential expression in normal tissues according to GTEx for PPP4C Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for PPP4C Gene

This gene is overexpressed in Nasal epithelium (13.0) and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP4C Gene



SOURCE GeneReport for Unigene cluster for PPP4C Gene Hs.534338

genes like me logo Genes that share expression patterns with PPP4C: view

Protein tissue co-expression partners for PPP4C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PPP4C Gene

Orthologs for PPP4C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP4C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP4C 35
  • 94.03 (n)
  • 100 (a)
PPP4C 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP4C 35
  • 93.92 (n)
  • 100 (a)
PPP4C 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp4c 35
  • 90.55 (n)
  • 100 (a)
Ppp4c 16
Ppp4c 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP4C 35
  • 99.67 (n)
  • 100 (a)
PPP4C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp4c 35
  • 90.77 (n)
  • 99.67 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP4C 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP4C 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP4C 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75928 35
ppp4c 35
  • 82.95 (n)
  • 99.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7081 35
zebrafish
(Danio rerio)
Actinopterygii ppp4cb 35
  • 80.24 (n)
  • 98.05 (a)
wufd05e08 35
ppp4ca 36
  • 94 (a)
OneToMany
ppp4cb 36
  • 98 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11597 37
  • 57 (a)
Pp4-19C 37
  • 91 (a)
Pp4-19C 35
  • 80.67 (n)
  • 91.53 (a)
Pp4-19C 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003779 35
  • 77.96 (n)
  • 93.49 (a)
worm
(Caenorhabditis elegans)
Secernentea C06A1.3 37
  • 43 (a)
C27B7.6 37
  • 32 (a)
C34C12.3 37
  • 54 (a)
F42G8.8 37
  • 35 (a)
F49E11.7 37
  • 32 (a)
F58G1.3 37
  • 40 (a)
pph-4.1 37
  • 81 (a)
pph-4.2 37
  • 72 (a)
W03D8.2 37
  • 41 (a)
Y40H4A.2 37
  • 37 (a)
pph-4.1 35
  • 69.09 (n)
  • 81.46 (a)
pph-4.1 36
  • 74 (a)
OneToMany
pph-4.2 36
  • 70 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR136W 35
  • 64.01 (n)
  • 65.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10055g 35
  • 57.14 (n)
  • 61.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH3 35
  • 55.26 (n)
  • 63.49 (a)
PPH21 36
  • 50 (a)
ManyToMany
PPH22 36
  • 48 (a)
ManyToMany
PPG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PPX2 35
  • 69.41 (n)
  • 82.57 (a)
soybean
(Glycine max)
eudicotyledons Gma.5783 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1970 35
rice
(Oryza sativa)
Liliopsida Os.17604 35
Os09g0284200 35
  • 71.18 (n)
  • 82.18 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.12768 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11282 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08301 35
  • 63.81 (n)
  • 71.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC26H8.05c 35
  • 60.49 (n)
  • 71.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10368 36
  • 89 (a)
OneToOne
Species with no ortholog for PPP4C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP4C Gene

ENSEMBL:
Gene Tree for PPP4C (if available)
TreeFam:
Gene Tree for PPP4C (if available)

Paralogs for PPP4C Gene

Paralogs for PPP4C Gene

genes like me logo Genes that share paralogs with PPP4C: view

Variants for PPP4C Gene

Sequence variations from dbSNP and Humsavar for PPP4C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4785 -- 30,084,782(+) AACTG(G/T)TGATG reference, missense
rs1042997 -- 30,085,094(+) CCCTT(C/T)TGGCC utr-variant-3-prime
rs1043065 -- 30,085,256(+) TCCCC(A/C)CTTGA utr-variant-3-prime
rs2278557 -- 30,082,458(+) GAGTT(C/G)CAACC intron-variant
rs2289291 -- 30,083,339(+) AGAGA(A/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP4C Gene

Variant ID Type Subtype PubMed ID
dgv2668n71 CNV Loss 21882294
nsv833187 CNV Loss 17160897
nsv905720 CNV Loss 21882294
dgv846e1 CNV Complex 17122850

Variation tolerance for PPP4C Gene

Residual Variation Intolerance Score: 21.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP4C Gene

HapMap Linkage Disequilibrium report
PPP4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4C Gene

Disorders for PPP4C Gene

MalaCards: The human disease database

(3) MalaCards diseases for PPP4C Gene - From: OMIM

Disorder Aliases PubMed IDs
lipodystrophy, congenital generalized, type 3
  • congenital generalized lipodystrophy 3
pulmonary hypertension, primary, 3
  • pph3
partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome
  • lipodystrophy, partial, with congenital cataracts and neurodegeneration
- elite association
Search PPP4C in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPP4C

Genetic Association Database (GAD)
PPP4C
Human Genome Epidemiology (HuGE) Navigator
PPP4C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP4C
genes like me logo Genes that share disorders with PPP4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP4C Gene

Publications for PPP4C Gene

  1. A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. (PMID: 20154705) Lee D.H. … Chowdhury D. (Nat. Struct. Mol. Biol. 2010) 23 67
  2. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. (PMID: 20065038) Douglas P. … Lees-Miller S.P. (Mol. Cell. Biol. 2010) 23 67
  3. Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. (PMID: 20118229) Moon S.H. … Donehower L.A. (J. Biol. Chem. 2010) 23 67
  4. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. (PMID: 19088085) Jia H. … Jia J. (Development 2009) 23 67
  5. Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions. (PMID: 19204120) Sousa-Nunes R. … Somers W.G. (Genes Dev. 2009) 23 67

Products for PPP4C Gene

Sources for PPP4C Gene

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