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Aliases for PPP3R2 Gene

Aliases for PPP3R2 Gene

  • Protein Phosphatase 3, Regulatory Subunit B, Beta 2 3
  • Protein Phosphatase 2B Regulatory Subunit 2 2 3 4
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Beta Isoform 2 3
  • Protein Phosphatase 3 Regulatory Subunit B Beta Isoform 3 4
  • Calcineurin B-Like Protein 3 4
  • Calcineurin BII 3 4
  • PPP3RL 3 4
  • CNBII 3 4
  • CBLP 3 4
  • Regulatory Subunit B (Calcineurin B)-Like 2
  • Calcineurin B, Type II (19kDa) 3
  • Protein Phosphatase 3 2
  • Type II (19kDa) 2
  • Calcineurin B 2
  • PPP3R1-Like 4

External Ids for PPP3R2 Gene

Previous GeneCards Identifiers for PPP3R2 Gene

  • GC00U990278
  • GC09M096097
  • GC09M097811
  • GC09M099733
  • GC09M101433
  • GC09M103393
  • GC09M104353
  • GC09M073954

Summaries for PPP3R2 Gene

GeneCards Summary for PPP3R2 Gene

PPP3R2 (Protein Phosphatase 3, Regulatory Subunit B, Beta) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and GPCR Pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for PPP3R2 Gene

  • Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).

Gene Wiki entry for PPP3R2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3R2 Gene

Genomics for PPP3R2 Gene

Regulatory Elements for PPP3R2 Gene

Genomic Location for PPP3R2 Gene

Chromosome:
9
Start:
101,591,615 bp from pter
End:
101,595,001 bp from pter
Size:
3,387 bases
Orientation:
Minus strand

Genomic View for PPP3R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP3R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3R2 Gene

Proteins for PPP3R2 Gene

  • Protein details for PPP3R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ3-CANB2_HUMAN
    Recommended name:
    Calcineurin subunit B type 2
    Protein Accession:
    Q96LZ3
    Secondary Accessions:
    • Q5VTR4
    • Q7Z4V8
    • Q8WYJ4

    Protein attributes for PPP3R2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19533 Da
    Quaternary structure:
    • Composed of a catalytic subunit (A) and a regulatory subunit (B)
    Miscellaneous:
    • This protein has four functional calcium-binding sites.
    SequenceCaution:
    • Sequence=AAH30595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66299.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAP57772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71521.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH69961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW58961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PPP3R2 Gene

Proteomics data for PPP3R2 Gene at MOPED

Post-translational modifications for PPP3R2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP3R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP3R2 Gene

Domains & Families for PPP3R2 Gene

Protein Domains for PPP3R2 Gene

Suggested Antigen Peptide Sequences for PPP3R2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LZ3

UniProtKB/Swiss-Prot:

CANB2_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the calcineurin regulatory subunit family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calcineurin regulatory subunit family.
genes like me logo Genes that share domains with PPP3R2: view

Function for PPP3R2 Gene

Molecular function for PPP3R2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).

Gene Ontology (GO) - Molecular Function for PPP3R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PPP3R2: view
genes like me logo Genes that share phenotypes with PPP3R2: view

Animal Model Products

miRNA for PPP3R2 Gene

miRTarBase miRNAs that target PPP3R2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP3R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP3R2 Gene

Localization for PPP3R2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP3R2 Gene COMPARTMENTS Subcellular localization image for PPP3R2 gene
Compartment Confidence
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP3R2 Gene

Pathways & Interactions for PPP3R2 Gene

genes like me logo Genes that share pathways with PPP3R2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPP3R2 Gene

None

No data available for SIGNOR curated interactions for PPP3R2 Gene

Drugs & Compounds for PPP3R2 Gene

(6) Drugs for PPP3R2 Gene - From: DGIdb, ApexBio, DrugBank, NovoSeek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational Pharma inhibitor, Target Immunosuppressant drug 0
Pimecrolimus Approved, Investigational Pharma 60
ISA247 Investigational Pharma Target 0
Calcium Nutra 0
CYCLOSPORINE A Pharma 0
genes like me logo Genes that share compounds with PPP3R2: view

Transcripts for PPP3R2 Gene

mRNA/cDNA for PPP3R2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP3R2 Gene

Protein phosphatase 3, regulatory subunit B, beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP3R2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3R2 Gene

No ASD Table

Relevant External Links for PPP3R2 Gene

GeneLoc Exon Structure for
PPP3R2
ECgene alternative splicing isoforms for
PPP3R2

Expression for PPP3R2 Gene

mRNA expression in normal human tissues for PPP3R2 Gene

mRNA differential expression in normal tissues according to GTEx for PPP3R2 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for PPP3R2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3R2 Gene



SOURCE GeneReport for Unigene cluster for PPP3R2 Gene Hs.151167

mRNA Expression by UniProt/SwissProt for PPP3R2 Gene

Q96LZ3-CANB2_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with PPP3R2: view

Protein tissue co-expression partners for PPP3R2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPP3R2 Gene

Orthologs for PPP3R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP3R2 35
  • 85.88 (n)
  • 86.47 (a)
dog
(Canis familiaris)
Mammalia PPP3R2 35
  • 84.69 (n)
  • 85.47 (a)
mouse
(Mus musculus)
Mammalia Ppp3r2 35
  • 81.76 (n)
  • 80.59 (a)
Ppp3r2 16
Ppp3r2 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP3R2 35
  • 99.61 (n)
  • 99.42 (a)
rat
(Rattus norvegicus)
Mammalia Ppp3r2 35
  • 83.53 (n)
  • 82.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CanB 36
  • 74 (a)
OneToMany
CanB2 36
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnb-1 36
  • 74 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 36
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4810 36
  • 75 (a)
OneToOne
Species with no ortholog for PPP3R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PPP3R2 Gene

ENSEMBL:
Gene Tree for PPP3R2 (if available)
TreeFam:
Gene Tree for PPP3R2 (if available)

Paralogs for PPP3R2 Gene

Paralogs for PPP3R2 Gene

(21) SIMAP similar genes for PPP3R2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP3R2: view

Variants for PPP3R2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP3R2 Gene

Variant ID Type Subtype PubMed ID
nsv831672 CNV Gain 17160897

Variation tolerance for PPP3R2 Gene

Residual Variation Intolerance Score: 80.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP3R2 Gene

HapMap Linkage Disequilibrium report
PPP3R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PPP3R2 Gene

Disorders for PPP3R2 Gene

Relevant External Links for PPP3R2

Genetic Association Database (GAD)
PPP3R2
Human Genome Epidemiology (HuGE) Navigator
PPP3R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP3R2
genes like me logo Genes that share disorders with PPP3R2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP3R2 Gene

Publications for PPP3R2 Gene

  1. Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. (PMID: 15865209) Liu L. … Yu L. (Mol. Biol. Rep. 2005) 2 23 67
  2. Breaking the code: Ca2+ sensors in plant signalling. (PMID: 20001960) DeFalco T.A. … Snedden W.A. (Biochem. J. 2010) 23 67
  3. Constitutive overexpression of the calcium sensor CBL5 confers osmotic or drought stress tolerance in Arabidopsis. (PMID: 20077023) Cheong Y.H. … Luan S. (Mol. Cells 2010) 23 67
  4. The CBL-CIPK network in plant calcium signaling. (PMID: 19054707) Luan S. (Trends Plant Sci. 2009) 23 67
  5. Plant calcineurin B-like proteins and their interacting protein kinases. (PMID: 19022300) Batistic O. … Kudla J. (Biochim. Biophys. Acta 2009) 23 67

Products for PPP3R2 Gene

Sources for PPP3R2 Gene

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