Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP3R2 Gene

protein-coding   GIFtS: 59
GCID: GC09M104353

Protein Phosphatase 3, Regulatory Subunit B, Beta

(Previous names: protein phosphatase 3 (formerly 2B), regulatory subunit...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 3, Regulatory Subunit B, Beta1 2     CNBII2 3
Protein Phosphatase 2B Regulatory Subunit 21 2 3     PPP3RL2 3
Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Beta
Isoform (Calcineurin B, Type II)1 2
     Calcineurin B1
Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Beta
Isoform (Calcineurin B, Type II)1 2
     Protein Phosphatase 31
Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Beta Isoform1 2     Regulatory Subunit B (Calcineurin B)-Like1
Calcineurin B-Like Protein2 3     Type II (19kDa)1
Calcineurin BII2 3     Calcineurin B, Type II (19kDa)2
Protein Phosphatase 3 Regulatory Subunit B Beta Isoform2 3     Calcineurin Subunit B Type 22
CBLP2 3     PPP3R1-like3

External Ids:    HGNC: 93181   Entrez Gene: 55352   Ensembl: ENSG000001883867   OMIM: 6138215   UniProtKB: Q96LZ33   

Export aliases for PPP3R2 gene to outside databases

Previous GC identifers: GC00U990278 GC09M096097 GC09M097811 GC09M099733 GC09M101433 GC09M103393 GC09M073954


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPP3R2 Gene: 
PPP3R2 (protein phosphatase 3, regulatory subunit B, beta) is a protein-coding gene. Diseases associated with PPP3R2 include lateral sclerosis, and amyotrophic lateral sclerosis, and among its related super-pathways are Fc epsilon RI signaling pathway and MAPK signaling pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP3R1.

UniProtKB/Swiss-Prot: CANB2_HUMAN, Q96LZ3
Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.
Confers calcium sensitivity (By similarity)

Gene Wiki entry for PPP3R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP3R2 gene promoter:
         Tal-1   AML1a   Lmo2   Nkx2-5   E47   Evi-1   AREB6   S8   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP3R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP3R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP3R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q31

PPP3R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP3R2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M104353:  view genomic region     (about GC identifiers)

Start:
104,353,897 bp from pter      End:
104,357,283 bp from pter
Size:
3,387 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CANB2_HUMAN, Q96LZ3 (See protein sequence)
Recommended Name: Calcineurin subunit B type 2  
Size: 170 amino acids; 19533 Da
Subunit: Composed of a catalytic subunit (A) and a regulatory subunit (B)
Miscellaneous: This protein has four functional calcium-binding sites (By similarity)
Sequence caution: Sequence=AAH30595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH66299.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAP57772.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB71521.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAH69961.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=EAW58961.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened;
Secondary accessions: Q5VTR4 Q7Z4V8 Q8WYJ4

Explore the universe of human proteins at neXtProt for PPP3R2: NX_Q96LZ3

Explore proteomics data for PPP3R2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LZ3

  • PPP3R2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP3R2 Protein Expression
    REFSEQ proteins: NP_671709.1  
    ENSEMBL proteins: 
     ENSP00000363939  

    Human Recombinant Protein Products for PPP3R2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPP3R2
    OriGene Protein Over-expression Lysate for PPP3R2
    OriGene MassSpec for PPP3R2 
    OriGene Custom Protein Services for PPP3R2
    GenScript Custom Purified and Recombinant Proteins Services for PPP3R2
    Novus Biologicals PPP3R2 Proteins
    Novus Biologicals PPP3R2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PPP3R2
    Cloud-Clone Corp. Proteins for PPP3R2 


    PPP3R2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PPP3R2
    GenScript Custom Superior Antibodies Services for PPP3R2
    Novus Biologicals PPP3R2 Antibodies
    Abcam antibodies for PPP3R2
    Cloud-Clone Corp. Antibodies for PPP3R2 
    ThermoFisher Antibody for PPP3R2
    LSBio Antibodies in human, mouse, rat for PPP3R2 

    Assay Products for PPP3R2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP3R2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP3R2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPP3R2 
    Cloud-Clone Corp. CLIAs for PPP3R2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP3R: Serine/threonine phosphatases / Protein phosphatase 3, regulatory subunits
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q96LZ3

    ProtoNet protein and cluster: Q96LZ3

    1 Blocks protein domain: IPB008080 Parvalbumin signature

    UniProtKB/Swiss-Prot: CANB2_HUMAN, Q96LZ3
    Similarity: Belongs to the calcineurin regulatory subunit family
    Similarity: Contains 4 EF-hand domains


    PPP3R2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CANB2_HUMAN, Q96LZ3
    Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.
    Confers calcium sensitivity (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    PPP3R2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPP3R2:
     Increased S DNA content, incre  Increased cell death in HCT116  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP3R2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP3R2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP3R2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP3R2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP3R2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP3R2:
    hsa-miR-2116* hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP3R2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP3R2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP3R2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP3R2
    Sirion Biotech Customized adenovirus for overexpression of PPP3R2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PPP3R2 (see all 6)
    OriGene ORF clones in mouse, rat for PPP3R2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP3R2 (NM_147180)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP3R2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3R2
    Sirion Biotech Customized lentivirus for stable overexpression of PPP3R2 
                         Customized lentivirus expression plasmids for stable overexpression of PPP3R2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP3R2
    Search LifeMap BioReagents cell lines for PPP3R2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3R2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP3R2 About   (see all 36)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.32
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    4fMLP Pathway
    fMLP Pathway0.43
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    514-3-3 Induced Apoptosis
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for PPP3R2
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Immune response CD16 signaling in NK cells
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP3R2 (see all 32)
        14-3-3 Induced Apoptosis
    Intracellular Calcium Signaling
    PI3K Signaling in B-Lymphocyte
    IL-2 Pathway
    ITK and TCR Signaling

    4 GeneGo (Thomson Reuters) Pathways for PPP3R2
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response CD16 signaling in NK cells
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    3 BioSystems Pathways for PPP3R2
        MAPK signaling pathway
    Energy Metabolism
    Alzheimers Disease

    1 PharmGKB Pathway for PPP3R2
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/18         Kegg Pathways  (Kegg details for PPP3R2) (see all 18):
        MAPK signaling pathway
    Calcium signaling pathway
    Oocyte meiosis
    Apoptosis
    Wnt signaling pathway


    PPP3R2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP3R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for PPP3R2 (Q96LZ33 ENSP000003639394) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBC1D10CQ8IV043, ENSP000003101934I2D: score=1 STRING: ENSP00000310193
    PLCG1ENSP000002440074STRING: ENSP00000244007
    PLCG2ENSP000003523364STRING: ENSP00000352336
    ANAPC1ENSP000003391094STRING: ENSP00000339109
    ANAPC10ENSP000003100714STRING: ENSP00000310071
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP3R2 for compounds           About GeneDecksing

    EMD Millipore small molecules for PPP3R2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP3R2 (CANB2)

    1 HMDB Compound for PPP3R2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for PPP3R2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CyclosporineCiclosporin (see all 4)59865-13-3targetinhibitor20674565 17016423 17139284

    2 Novoseek inferred chemical compound relationships for PPP3R2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 46.6 16 17825054 (1), 19054707 (1), 15322881 (1), 17922773 (1) (see all 8)
    threonine 32 1 11481038 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP3R2 / CANB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP3R2 gene: 
    NM_147180.2  

    Unigene Cluster for PPP3R2:

    Protein phosphatase 3, regulatory subunit B, beta
    Hs.151167  [show with all ESTs]
    Unigene Representative Sequence: BC030595
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374806(uc004bbr.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP3R2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP3R2:
    hsa-miR-2116* hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP3R2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP3R2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP3R2
    Clone
    Products:
         
    OriGene clones in human, mouse for PPP3R2 (see all 6)
    OriGene ORF clones in mouse, rat for PPP3R2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP3R2 (NM_147180)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP3R2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3R2
    Sirion Biotech Customized lentivirus for stable overexpression of PPP3R2 
                         Customized lentivirus expression plasmids for stable overexpression of PPP3R2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP3R2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP3R2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP3R2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP3R2

    Additional mRNA sequence: 

    AF085237.1 AF145026.1 AF400667.1 AK057524.1 AK302547.1 AK310471.1 BC030595.2 BC066299.1 

    1 DOTS entry:

    DT.311643 

    24/57 AceView cDNA sequences (see all 57):

    BI829745 AF145026 AI014984 NM_147180 AA953895 AA909534 AI221970 BC030595 
    AA428462 AI914363 AA431190 AK057524 BM559421 AA429551 BG720768 CD359160 
    BI560682 AA629305 BI559523 BI559526 AA431516 AI936596 BG719837 AI024938 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP3R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGTTAGGT
    PPP3R2 Expression
    About this image


    See PPP3R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP3R2

    SOURCE GeneReport for Unigene cluster: Hs.151167

    UniProtKB/Swiss-Prot: CANB2_HUMAN, Q96LZ3
    Tissue specificity: Testis-specific

        SABiosciences Expression via Pathway-Focused PCR Array including PPP3R2: 
              VEGF Signaling in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP3R2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP3R2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP3R2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP3R2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3R2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPP3R2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp3r21 , 5 protein phosphatase 3, regulatory subunit B, alpha more1, 5 81.76(n)1
    80.59(a)1
      4 (26.75 cM)5
    190591  NM_001004025.41  NP_001004025.11 
     496787475 
    chicken
    (Gallus gallus)
    Aves PPP3R16
    WDR926
    WD repeat-containing protein 92
    85(a)
    2(a)
    1 ↔ many
    1 ↔ many
    3(11142465-11175965)
    3(11131168-11137396)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    20(a)
    possible ortholog
    1(126546387-126637462)
    zebrafish
    (Danio rerio)
    Actinopterygii ppp3r1b6
    ppp3r1a6
    (see all 3)
    protein phosphatase 3 (formerly 2B), regulatory s1...
    protein phosphatase 3 (formerly 2B), regulatory s1...
    (see all 3)
    85(a)
    84(a)
    (see all 3)
    possible ortholog
    1 ↔ many
    (see all 3)
    1(52066629-52100276)
    13(972098-992674)
    fruit fly
    (Drosophila melanogaster)
    Insecta CanB26
    CanB6
    (see all 3)
    Calcineurin B
    (see all 3)
    76(a)
    74(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    2R(3673517-3676558)
    X(5226532-5228482)
    worm
    (Caenorhabditis elegans)
    Secernentea cnb-16
    Protein CNB-1, isoform b
    74(a)
    possible ortholog
    V(11375742-11378057)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNB11 Cnb1p 57.48(n)
    58.97(a)
      853644   NP_012731.1 


    ENSEMBL Gene Tree for PPP3R2 (if available)
    TreeFam Gene Tree for PPP3R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP3R2 gene
    PPP3R12  CHP22  WDR922  CHP12  
    18/22 SIMAP similar genes for PPP3R2 using alignment to 1 protein entry:     CANB2_HUMAN(see all similar genes):
    PPP3R1    NCALD    CETN1    CETN2    CALM1    CALM2
    CALM3    NCS1    HPCAL1    CHP1    CALML3    CHP2
    DKFZp781K1922    LOC63928    TNNC2    CIB2    VSNL1    CIB3

    PPP3R2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPP3R2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831672CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP3R2
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP3R2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613821    OMIM disorders: --

    5 diseases for PPP3R2:    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    tuberculosis    alzheimer's disease
    neuronitis


    PPP3R2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP3R2
    Human Genome Epidemiology (HuGE) Navigator: PPP3R2 (8 documents)

    Export disorders for PPP3R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP3R2 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with PPP3R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. (PubMed id 15865209)1, 2, 3, 9 Liu L....Yu L. (2005)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Comparison of the efficacy of tacrolimus and cyclospo rine A in a murine model of dinitrofluorobenzene-induced atopic dermatitis. (PubMed id 20674565)7 Yamashita H....Inagaki N. (2010)
    8. Are calcineurin genes associated with endurance pheno type traits? (PubMed id 20107831)1 He Z.H....Lucia A. (2010)
    9. Genomewide pharmacogenomic study of metabolic side ef fects to antipsychotic drugs. (PubMed id 20195266)4 Adkins D.E....van den Oord E.J. (2010)
    10. Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults . (PubMed id 20593291)1 He Z.H....Lucia A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5535 HGNC: 9318 AceView: PPP3R2 Ensembl:ENSG00000188386 euGenes: HUgn5535
    ECgene: PPP3R2 Kegg: 5535 H-InvDB: PPP3R2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP3R2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP3R2 gene:
    Search GeneIP for patents involving PPP3R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PPP3R2
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PPP3R2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PPP3R2  
     OriGene MassSpec something-or-other for PPP3R2   OriGene clones in human, mouse for PPP3R2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPP3R2   OriGene Purified Protein for PPP3R2  
     OriGene ORF clones in mouse, rat for PPP3R2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP3R2   OriGene Custom Protein Services for PPP3R2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP3R2
     QIAGEN SeqTarget long-range PCR primers for resequencing PPP3R2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP3R2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP3R2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP3R2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP3R2
     GenScript Custom Purified and Recombinant Proteins Services for PPP3R2 GenScript cDNA clones with any tag delivered in your preferred vector for PPP3R2
     GenScript Custom Assay Services for PPP3R2 GenScript Custom Superior Antibodies Services for PPP3R2
     GenScript Custom overexpressing Cell Line Services for PPP3R2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PPP3R2 promoter
     Search Chromatin IP Primers for PPP3R2
     RT2 qPCR Primer Assay in human, mouse, rat PPP3R2
     Search GNC Networks for PPP3R2
     SABiosciences PCR Arrays including human, mouse, rat PPP3R2
     Search Tocris compounds for PPP3R2 (CANB2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PPP3R2 antibodies
     PPP3R2 proteins
     PPP3R2 lysates
     Antibodies for PPP3R2
     See all of Abcam's Antibodies, Kits and Proteins for PPP3R2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PPP3R2




     Proteins for PPP3R2
     Antibodies for PPP3R2
     ELISAs for PPP3R2
     CLIAs for PPP3R2
     Search LifeMap BioReagents cell lines for PPP3R2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3R2
     SwitchGear 3'UTR luciferase reporter plasmids for PPP3R2
     SwitchGear Promoter luciferase reporter plasmids for PPP3R2
     ThermoFisher Antibody for PPP3R2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3R2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP3R2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP3R2
    Customized:
     lentivirus for stable overexpression of PPP3R2
     lentivirus expression plasmids for stable overexpression of PPP3R2
     adenovirus for overexpression of PPP3R2
     LSBio Antibodies in human, mouse, rat for PPP3R2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP3R2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4