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Aliases for PPP3R2 Gene

Aliases for PPP3R2 Gene

  • Protein Phosphatase 3 Regulatory Subunit B, Beta 2 3 5
  • Protein Phosphatase 2B Regulatory Subunit 2 2 3 4
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Beta Isoform 2 3
  • Protein Phosphatase 3 Regulatory Subunit B Beta Isoform 3 4
  • Calcineurin B, Type II (19kDa) 2 3
  • Calcineurin B-Like Protein 3 4
  • Calcineurin BII 3 4
  • PPP3RL 3 4
  • CNBII 3 4
  • CBLP 3 4
  • Protein Phosphatase 3, Regulatory Subunit B (Calcineurin B)-Like 2
  • Protein Phosphatase 3, Regulatory Subunit B, Beta 2
  • Calcineurin Subunit B Type 2 3
  • PPP3R1-Like 4

External Ids for PPP3R2 Gene

Previous GeneCards Identifiers for PPP3R2 Gene

  • GC00U990278
  • GC09M096097
  • GC09M097811
  • GC09M099733
  • GC09M101433
  • GC09M103393
  • GC09M104353
  • GC09M073954

Summaries for PPP3R2 Gene

GeneCards Summary for PPP3R2 Gene

PPP3R2 (Protein Phosphatase 3 Regulatory Subunit B, Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP3R1.

UniProtKB/Swiss-Prot for PPP3R2 Gene

  • Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).

Gene Wiki entry for PPP3R2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3R2 Gene

Genomics for PPP3R2 Gene

Regulatory Elements for PPP3R2 Gene

Enhancers for PPP3R2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PPP3R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP3R2 Gene

Chromosome:
9
Start:
101,591,615 bp from pter
End:
101,595,021 bp from pter
Size:
3,407 bases
Orientation:
Minus strand

Genomic View for PPP3R2 Gene

Genes around PPP3R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3R2 Gene

Proteins for PPP3R2 Gene

  • Protein details for PPP3R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ3-CANB2_HUMAN
    Recommended name:
    Calcineurin subunit B type 2
    Protein Accession:
    Q96LZ3
    Secondary Accessions:
    • Q5VTR4
    • Q7Z4V8
    • Q8WYJ4

    Protein attributes for PPP3R2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19533 Da
    Quaternary structure:
    • Composed of a catalytic subunit (A) and a regulatory subunit (B).
    Miscellaneous:
    • This protein has four functional calcium-binding sites.
    SequenceCaution:
    • Sequence=AAH30595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66299.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAP57772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71521.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH69961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW58961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PPP3R2 Gene

Post-translational modifications for PPP3R2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP3R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP3R2 Gene

Domains & Families for PPP3R2 Gene

Protein Domains for PPP3R2 Gene

Suggested Antigen Peptide Sequences for PPP3R2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LZ3

UniProtKB/Swiss-Prot:

CANB2_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the calcineurin regulatory subunit family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calcineurin regulatory subunit family.
genes like me logo Genes that share domains with PPP3R2: view

Function for PPP3R2 Gene

Molecular function for PPP3R2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).

Gene Ontology (GO) - Molecular Function for PPP3R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PPP3R2: view
genes like me logo Genes that share phenotypes with PPP3R2: view

Animal Models for PPP3R2 Gene

MGI Knock Outs for PPP3R2:

Animal Model Products

CRISPR Products

miRNA for PPP3R2 Gene

miRTarBase miRNAs that target PPP3R2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3R2 Gene

Localization for PPP3R2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP3R2 Gene COMPARTMENTS Subcellular localization image for PPP3R2 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP3R2 Gene

Pathways & Interactions for PPP3R2 Gene

genes like me logo Genes that share pathways with PPP3R2: view

Gene Ontology (GO) - Biological Process for PPP3R2 Gene

None

No data available for SIGNOR curated interactions for PPP3R2 Gene

Drugs & Compounds for PPP3R2 Gene

(6) Drugs for PPP3R2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, inhibitor, Target Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Pimecrolimus Approved, Investigational Pharma 62
ISA247 Investigational Pharma Target 0
calcium Nutra 0
CYCLOSPORINE A Pharma 0

(2) ApexBio Compounds for PPP3R2 Gene

Compound Action Cas Number
Cyclosporine Immunosuppressant drug 79217-60-0
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3R2: view

Transcripts for PPP3R2 Gene

mRNA/cDNA for PPP3R2 Gene

Unigene Clusters for PPP3R2 Gene

Protein phosphatase 3, regulatory subunit B, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3R2 Gene

No ASD Table

Relevant External Links for PPP3R2 Gene

GeneLoc Exon Structure for
PPP3R2
ECgene alternative splicing isoforms for
PPP3R2

Expression for PPP3R2 Gene

mRNA expression in normal human tissues for PPP3R2 Gene

mRNA differential expression in normal tissues according to GTEx for PPP3R2 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for PPP3R2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP3R2 Gene



Protein tissue co-expression partners for PPP3R2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP3R2 Gene:

PPP3R2

SOURCE GeneReport for Unigene cluster for PPP3R2 Gene:

Hs.151167

mRNA Expression by UniProt/SwissProt for PPP3R2 Gene:

Q96LZ3-CANB2_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with PPP3R2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPP3R2 Gene

Orthologs for PPP3R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP3R2 34
  • 85.88 (n)
  • 86.47 (a)
dog
(Canis familiaris)
Mammalia PPP3R2 34
  • 84.69 (n)
  • 85.47 (a)
mouse
(Mus musculus)
Mammalia Ppp3r2 34
  • 81.76 (n)
  • 80.59 (a)
Ppp3r2 16
Ppp3r2 35
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP3R2 34
  • 99.61 (n)
  • 99.42 (a)
rat
(Rattus norvegicus)
Mammalia Ppp3r2 34
  • 83.53 (n)
  • 82.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CanB 35
  • 74 (a)
OneToMany
CanB2 35
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnb-1 35
  • 74 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 35
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4810 35
  • 75 (a)
OneToOne
Species where no ortholog for PPP3R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PPP3R2 Gene

ENSEMBL:
Gene Tree for PPP3R2 (if available)
TreeFam:
Gene Tree for PPP3R2 (if available)

Paralogs for PPP3R2 Gene

Paralogs for PPP3R2 Gene

(21) SIMAP similar genes for PPP3R2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP3R2: view

Variants for PPP3R2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP3R2 Gene

Variant ID Type Subtype PubMed ID
nsv831672 CNV gain 17160897

Variation tolerance for PPP3R2 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP3R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP3R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PPP3R2 Gene

Disorders for PPP3R2 Gene

Relevant External Links for PPP3R2

Genetic Association Database (GAD)
PPP3R2
Human Genome Epidemiology (HuGE) Navigator
PPP3R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP3R2

No disorders were found for PPP3R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP3R2 Gene

Publications for PPP3R2 Gene

  1. Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. (PMID: 15865209) Liu L. … Yu L. (Mol. Biol. Rep. 2005) 2 3 4 22 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for PPP3R2 Gene

Sources for PPP3R2 Gene

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