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Aliases for PPP3R2 Gene

Aliases for PPP3R2 Gene

  • Protein Phosphatase 3, Regulatory Subunit B, Beta 2 3
  • Protein Phosphatase 2B Regulatory Subunit 2 2 3 4
  • PPP3RL 3 4 6
  • CBLP 3 4 6
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Beta Isoform 2 3
  • Protein Phosphatase 3 Regulatory Subunit B Beta Isoform 3 4
  • Calcineurin B-Like Protein 3 4
  • Calcineurin BII 3 4
  • CNBII 3 4
  • Regulatory Subunit B (Calcineurin B)-Like 2
  • Calcineurin B, Type II (19kDa) 3
  • Calcineurin Subunit B Type 2 3
  • Protein Phosphatase 3 2
  • Type II (19kDa) 2
  • Calcineurin B 2
  • PPP3R1-Like 4

External Ids for PPP3R2 Gene

Summaries for PPP3R2 Gene

GeneCards Summary for PPP3R2 Gene

PPP3R2 (Protein Phosphatase 3, Regulatory Subunit B, Beta) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and GPCR Pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for PPP3R2 Gene

  • Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).

Gene Wiki entry for PPP3R2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3R2 Gene

Genomics for PPP3R2 Gene

Genomic Location for PPP3R2 Gene

Start:
101,591,615 bp from pter
End:
101,595,001 bp from pter
Size:
3,387 bases
Orientation:
Minus strand

Genomic View for PPP3R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP3R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3R2 Gene

Regulatory Elements for PPP3R2 Gene

Proteins for PPP3R2 Gene

  • Protein details for PPP3R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ3-CANB2_HUMAN
    Recommended name:
    Calcineurin subunit B type 2
    Protein Accession:
    Q96LZ3
    Secondary Accessions:
    • Q5VTR4
    • Q7Z4V8
    • Q8WYJ4

    Protein attributes for PPP3R2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19533 Da
    Quaternary structure:
    • Composed of a catalytic subunit (A) and a regulatory subunit (B)
    Miscellaneous:
    • This protein has four functional calcium-binding sites.
    SequenceCaution:
    • Sequence=AAH30595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66299.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAP57772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71521.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH69961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW58961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PPP3R2 Gene

Proteomics data for PPP3R2 Gene at MOPED

Post-translational modifications for PPP3R2 Gene

Other Protein References for PPP3R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP3R2 Gene

Domains for PPP3R2 Gene

Gene Families for PPP3R2 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • PPP3R :Serine/threonine phosphatases / Protein phosphatase 3, regulatory subunits

Protein Domains for PPP3R2 Gene

UniProtKB/Swiss-Prot:

CANB2_HUMAN
Domain:
  • Contains 4 EF-hand domains.:
    • Q96LZ3
Family:
  • Belongs to the calcineurin regulatory subunit family.:
    • Q96LZ3
genes like me logo Genes that share domains with PPP3R2: view

Function for PPP3R2 Gene

Molecular function for PPP3R2 Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).

Gene Ontology (GO) - Molecular Function for PPP3R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PPP3R2: view

Phenotypes for PPP3R2 Gene

genes like me logo Genes that share phenotypes with PPP3R2: view

miRNA for PPP3R2 Gene

miRTarBase miRNAs that target PPP3R2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP3R2 Gene

Localization for PPP3R2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP3R2 Gene COMPARTMENTS Subcellular localization image for PPP3R2 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PPP3R2 Gene

Pathways for PPP3R2 Gene

genes like me logo Genes that share pathways with PPP3R2: view

Gene Ontology (GO) - Biological Process for PPP3R2 Gene

None

Compounds for PPP3R2 Gene

(1) HMDB Compounds for PPP3R2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for PPP3R2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cyclosporine
  • Ciclosporin
59865-13-3 target inhibitor

(2) Novoseek inferred chemical compound relationships for PPP3R2 Gene

Compound -log(P) Hits PubMed IDs
calcium 46.6 8
threonine 32 1
genes like me logo Genes that share compounds with PPP3R2: view

Transcripts for PPP3R2 Gene

mRNA/cDNA for PPP3R2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP3R2 Gene

Protein phosphatase 3, regulatory subunit B, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3R2 Gene

No ASD Table

Relevant External Links for PPP3R2 Gene

GeneLoc Exon Structure for
PPP3R2
ECgene alternative splicing isoforms for
PPP3R2

Expression for PPP3R2 Gene

mRNA expression in normal human tissues for PPP3R2 Gene

mRNA differential expression in normal tissues according to GTEx for PPP3R2 Gene

This gene is overexpressed in Testis (51.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3R2 Gene

SOURCE GeneReport for Unigene cluster for PPP3R2 Gene Hs.151167

mRNA Expression by UniProt/SwissProt for PPP3R2 Gene

Q96LZ3-CANB2_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with PPP3R2: view

Orthologs for PPP3R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP3R2 36
  • 99.61 (n)
  • 99.42 (a)
cow
(Bos Taurus)
Mammalia PPP3R2 36
  • 85.88 (n)
  • 86.47 (a)
dog
(Canis familiaris)
Mammalia PPP3R2 36
  • 84.69 (n)
  • 85.47 (a)
mouse
(Mus musculus)
Mammalia Ppp3r2 36
  • 81.76 (n)
  • 80.59 (a)
Ppp3r2 16
Ppp3r2 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp3r2 36
  • 83.53 (n)
  • 82.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CanB 37
  • 74 (a)
OneToMany
CanB2 37
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnb-1 37
  • 74 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 37
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4810 37
  • 75 (a)
OneToOne
Species with no ortholog for PPP3R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PPP3R2 Gene

ENSEMBL:
Gene Tree for PPP3R2 (if available)
TreeFam:
Gene Tree for PPP3R2 (if available)

Paralogs for PPP3R2 Gene

Paralogs for PPP3R2 Gene

Selected SIMAP similar genes for PPP3R2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP3R2: view

Variants for PPP3R2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP3R2 Gene

Variant ID Type Subtype PubMed ID
nsv831672 CNV Gain 17160897

Relevant External Links for PPP3R2 Gene

HapMap Linkage Disequilibrium report
PPP3R2

No data available for Sequence variations from dbSNP and Humsavar for PPP3R2 Gene

Disorders for PPP3R2 Gene

Relevant External Links for PPP3R2

Genetic Association Database (GAD)
PPP3R2
Human Genome Epidemiology (HuGE) Navigator
PPP3R2
genes like me logo Genes that share disorders with PPP3R2: view

No data available for UniProtKB/Swiss-Prot for PPP3R2 Gene

Publications for PPP3R2 Gene

  1. Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. (PMID: 15865209) Liu L. … Yu L. (Mol. Biol. Rep. 2005) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 49
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for PPP3R2 Gene

Sources for PPP3R2 Gene

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