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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP3R1 Gene

protein-coding   GIFtS: 68
GCID: GC02M068358

Protein Phosphatase 3, Regulatory Subunit B, Alpha

(Previous names: protein phosphatase 3 (formerly 2B), regulatory subunit...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 3, Regulatory Subunit B, Alpha1 2     Calcineurin B1
Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Alpha
Isoform (Calcineurin B, Type I)1 2
     Type I (19kDa)1
Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Alpha
Isoform (Calcineurin B, Type I)1 2
     CNB12
Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Alpha Isoform1 2     Calcineurin B, Type I (19kDa)2
Protein Phosphatase 2B Regulatory Subunit B Alpha1 2     Calcineurin Subunit B Type 12
Protein Phosphatase 2B Regulatory Subunit 12 3     CNA23
CNB2 3     Protein Phosphatase 3 Regulatory Subunit B Alpha Isoform 13
CALNB12 5     

External Ids:    HGNC: 93171   Entrez Gene: 55342   Ensembl: ENSG000002218237   OMIM: 6013025   UniProtKB: P630983   

Export aliases for PPP3R1 gene to outside databases

Previous GC identifers: GC02M068539 GC02M068363 GC02M068324 GC02M068380 GC02M068261 GC02M068317 GC02M068259 GC02M068143


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPP3R1 Gene: 
PPP3R1 (protein phosphatase 3, regulatory subunit B, alpha) is a protein-coding gene. Diseases associated with PPP3R1 include calcaneonavicular coalition, and lobular neoplasia, and among its related super-pathways are Fc epsilon RI signaling pathway and MAPK signaling pathway. GO annotations related to this gene include calmodulin binding and calcium ion binding. An important paralog of this gene is PPP3R2.

UniProtKB/Swiss-Prot: CANB1_HUMAN, P63098
Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.
Confers calcium sensitivity

Gene Wiki entry for PPP3R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP3R1 gene promoter:
         MEF-2A   GR   AP-1   MEF-2   FOXO4   aMEF-2   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP3R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP3R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP3R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

PPP3R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP3R1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M068358:  view genomic region     (about GC identifiers)

Start:
68,358,370 bp from pter      End:
68,488,362 bp from pter
Size:
129,993 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CANB1_HUMAN, P63098 (See protein sequence)
Recommended Name: Calcineurin subunit B type 1  
Size: 170 amino acids; 19300 Da
Subunit: Composed of a catalytic subunit (A) and a regulatory subunit (B)
Miscellaneous: This protein has four functional calcium-binding sites
6 PDB 3D structures from and Proteopedia for PPP3R1:
1AUI (3D)        1M63 (3D)        1MF8 (3D)        2P6B (3D)        3LL8 (3D)        4F0Z (3D)    
Secondary accessions: B2RC10 B5MDU4 P06705 P15117 Q08044 Q53SL0

Explore the universe of human proteins at neXtProt for PPP3R1: NX_P63098

Explore proteomics data for PPP3R1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P63098

  • PPP3R1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP3R1 Protein Expression
    REFSEQ proteins: NP_000936.1  
    ENSEMBL proteins: 
     ENSP00000384974   ENSP00000234310   ENSP00000387216   ENSP00000387148  
    Reactome Protein details: P63098
    Human Recombinant Protein Products for PPP3R1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for PPP3R1
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    Novus Biologicals PPP3R1 Proteins
    Novus Biologicals PPP3R1 Lysates
    Sino Biological Recombinant Protein for PPP3R1
    Sino Biological Cell Lysate for PPP3R1 
    ProSpec Recombinant Protein for PPP3R1
    Cloud-Clone Corp. Proteins for PPP3R1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005955calcineurin complex NAS2558868

    PPP3R1 for ontologies           About GeneDecksing



    PPP3R1 Antibody Products: 
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    ThermoFisher Antibody for PPP3R1
    LSBio Antibodies in human, mouse, rat for PPP3R1 

    Assay Products for PPP3R1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP3R: Serine/threonine phosphatases / Protein phosphatase 3, regulatory subunits
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P63098

    ProtoNet protein and cluster: P63098

    2 Blocks protein domains:
    IPB001751 Calcium-binding protein
    IPB008080 Parvalbumin signature


    UniProtKB/Swiss-Prot: CANB1_HUMAN, P63098
    Similarity: Belongs to the calcineurin regulatory subunit family
    Similarity: Contains 4 EF-hand domains


    PPP3R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CANB1_HUMAN, P63098
    Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.
    Confers calcium sensitivity

         Genatlas biochemistry entry for PPP3R1:
    calcineurin B,calmodulin dependent protein serine/threonine phosphatase 3,regulatory subunit

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004723calcium-dependent protein serine/threonine phosphatase activity NAS2558868
    GO:0005509calcium ion binding NAS2558868
    GO:0005515protein binding IPI19896943
    GO:0005516calmodulin binding NAS2558868
    GO:0019904protein domain specific binding IPI--
         
    PPP3R1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPP3R1:
     Decreased focal adhesion (FA)   Metaphase cells  Synthetic lethal with c-Myc af 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ppp3r1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     renal/urinary system 

    PPP3R1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp3r1tm2.1Grc for PPP3R1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP3R1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP3R1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP3R1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP3R1 

    miRNA
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    miRTarBase miRNAs that target PPP3R1:
    hsa-mir-30a (MIRT005180)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP3R1
    8/143 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP3R1 (see all 143):
    hsa-miR-411* hsa-miR-640 hsa-miR-106a hsa-miR-342-3p hsa-miR-502-3p hsa-miR-3916 hsa-miR-298 hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidPPP3R1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP3R1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP3R1

    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP3R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3R1
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                         Customized lentivirus expression plasmids for stable overexpression of PPP3R1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3R1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP3R1 About   (see all 46)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.32
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    4fMLP Pathway
    fMLP Pathway0.43
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    5Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for PPP3R1
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Immune response CD16 signaling in NK cells
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction Activation of PKC via G-Protein coupled receptor

    2 R&D Systems Pathways for PPP3R1
        Wnt Signaling Pathway
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP3R1 (see all 32)
        14-3-3 Induced Apoptosis
    Intracellular Calcium Signaling
    PI3K Signaling in B-Lymphocyte
    IL-2 Pathway
    ITK and TCR Signaling

    4 GeneGo (Thomson Reuters) Pathways for PPP3R1
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response CD16 signaling in NK cells
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5 BioSystems Pathways for PPP3R1
        MAPK signaling pathway
    TFs Regulate miRNAs related to cardiac hypertrophy
    Energy Metabolism
    B Cell Receptor Signaling Pathway
    Alzheimers Disease


    5/12        Reactome Pathways for PPP3R1 (see all 12)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Signaling by GPCR
    Apoptosis
    Opioid Signalling

    1 PharmGKB Pathway for PPP3R1
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/18         Kegg Pathways  (Kegg details for PPP3R1) (see all 18):
        MAPK signaling pathway
    Calcium signaling pathway
    Oocyte meiosis
    Apoptosis
    Wnt signaling pathway


    PPP3R1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP3R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/157 Interacting proteins for PPP3R1 (P630982, 3 ENSP000002343104) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-58232 I2D: score=5 
    CALM3P621582, 3MINT-58232 I2D: score=5 
    MAP3K5Q996832, 3, ENSP000003519084MINT-8223296 MINT-8223355 I2D: score=3 STRING: ENSP00000351908
    BCL2P104152, 3, ENSP000003296234MINT-58237 MINT-58234 I2D: score=1 STRING: ENSP00000329623
    PPP3CAQ082092, 3, ENSP000003783234MINT-7296006 I2D: score=9 STRING: ENSP00000378323
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--
    GO:0045087innate immune response TAS--
    GO:0097193intrinsic apoptotic signaling pathway TAS--
    GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS--

    PPP3R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP3R1 for compounds           About GeneDecksing

    EMD Millipore small molecules for PPP3R1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP3R1 (CANB1)

    1 HMDB Compound for PPP3R1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for PPP3R1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --target--10592235

    3 Novoseek inferred chemical compound relationships for PPP3R1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 50.3 4 7525078 (2), 8880916 (1)
    cyclosporin a 35.5 3 7525078 (2), 20421389 (1)
    calcium 8.67 6 19536897 (3), 10822252 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP3R1 / CANB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP3R1 gene: 
    NM_000945.3  

    Unigene Cluster for PPP3R1:

    Protein phosphatase 3, regulatory subunit B, alpha
    Hs.280604  [show with all ESTs]
    Unigene Representative Sequence: BC027913
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406334 ENST00000234310(uc002sei.1) ENST00000409752 ENST00000409377


    miRNA
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    8/143 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP3R1 (see all 143):
    hsa-miR-411* hsa-miR-640 hsa-miR-106a hsa-miR-342-3p hsa-miR-502-3p hsa-miR-3916 hsa-miR-298 hsa-miR-520b
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP3R1
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    Additional mRNA sequence: 

    AK307136.1 AK314893.1 BC027913.1 CR456938.1 

    6 DOTS entries:

    DT.86821373  DT.92459728  DT.100725426  DT.100813379  DT.100813378  DT.121034831 

    24/430 AceView cDNA sequences (see all 430):

    NM_173177 AI375251 CR593156 BX340492 AA805413 BP350152 AI335801 BM263178 
    BC020271 AW014787 BM354091 BM786368 AA283054 BU675203 AA305785 BF223912 
    CK820229 BM129531 AI476631 NM_000945 AI285866 AA703412 BI093844 W01341 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP3R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGGGATC
    PPP3R1 Expression
    About this image


    See PPP3R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP3R1

    SOURCE GeneReport for Unigene cluster: Hs.280604
        SABiosciences Expression via Pathway-Focused PCR Arrays including PPP3R1: 
              VEGF Signaling in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP3R1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3R1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPP3R1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp3r11 , 5 protein phosphatase 3, regulatory subunit B, alpha more1, 5 94.51(n)1
    100(a)1
      11 (9.71 cM)5
    190581  NM_024459.21  NP_077779.21 
     171592635 
    chicken
    (Gallus gallus)
    Aves PPP3R11 protein phosphatase 3, regulatory subunit B, alpha 91.18(n)
    100(a)
      378804  NM_204376.2  NP_989707.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    23(a)
    possible ortholog
    1(126546387-126637462)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY336971.12   -- 90.97(n)    AY336971.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nrarpa2 notch-regulated ankyrin repeat protein a 81.44(n)    CF999354.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CanB21 , 3 protein amino acid dephosphorylation
    calmodulin more3
    Calcineurin B21
    87(a)
    (best of 2)3
    72.16(n)1
    87.65(a)1
      2 43E163
    464561  NM_080135.31  NP_524874.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cnb-11 Protein CNB-1 67.65(n)
    79.29(a)
      179572  NM_073484.4  NP_505885.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNB16
    Calcineurin B; the regulatory subunit of calcineur...
    51(a)
    1 → many
    XI(82947-83550)


    ENSEMBL Gene Tree for PPP3R1 (if available)
    TreeFam Gene Tree for PPP3R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP3R1 gene
    PPP3R22  CHP22  WDR922  CHP12  
    18/29 SIMAP similar genes for PPP3R1 using alignment to 4 protein entries:     CANB1_HUMAN (see all proteins) (see all similar genes):
    HZGJ    PPP3R2    CIB1    GUCA1A    CETN2    CALM3
    CALM2    CETN1    NCS1    CIB2    CIB3    CALM1
    CALML3    TNNC2    CHP1    VSNL1    TNNC1    NCALD

    PPP3R1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPP3R1
    PGOHUM00000250429


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1486 SNPs in PPP3R1 are shown (see all 1486)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746096981,2
    C,F--68405539(+) AATACA/C/GTAAGT 1 -- int11WA 118
    rs286940541,2
    C,F,H--68405545(+) TAAGTG/AAACTG 1 -- int122Minor allele frequency- A:0.49NS EA NA WA CSA 2345
    rs1889949621,2
    --68405569(+) TAAATA/GCCATT 1 -- int10--------
    rs1819919181,2
    --68405576(+) CATTGC/TAGAAG 1 -- int10--------
    rs1863322401,2
    --68405614(+) CAGGCA/GTATCT 1 -- int10--------
    rs2010289611,2
    --68405615(+) AGGCG-/TATCTG 1 -- int10--------
    rs1461215131,2
    C--68405654(+) TCCTTC/TTGAGC 1 -- int10--------
    rs1883313931,2
    --68405898(+) CACTTC/TACCAG 1 -- int10--------
    rs1401494091,2
    C--68406022(+) CATACA/GGTATG 1 -- ut310--------
    rs1422282951,2
    C--68406024(+) TACAGC/TATGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP3R1 (68358370 - 68488362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPP3R1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv874249CNV Loss21882294
    nsv834251CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601302    OMIM disorders: --

    13 diseases for PPP3R1:    About MalaCards
    calcaneonavicular coalition    lobular neoplasia    pneumothorax    lateral sclerosis
    amyotrophic lateral sclerosis    psoriasis    hepatitis b    hypoxia
    alzheimer's disease    schizophrenia    tuberculosis    hepatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PPP3R1:
    Calcaneonavicular coalition

    PPP3R1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PPP3R1
    Human Genome Epidemiology (HuGE) Navigator: PPP3R1 (15 documents)

    Export disorders for PPP3R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP3R1 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with PPP3R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. (PubMed id 2558868)1, 2, 3 Guerini D....Klee C.B. (1989)
    2. Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. (PubMed id 16209992)1, 4, 9 Tang W....Ferrell R.E. (2005)
    3. SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. (PubMed id 20862329)1, 4 Cruchaga C....Goate A.M. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    7. The combined impact of metabolic gene polymorphisms o n elite endurance athlete status and related phenotypes. (PubMed id 19653005)1, 4 Ahmetov I.I....Rogozkin V.A. (2009)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. (PubMed id 12357034)1, 2 Jin L. and Harrison S.C. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5534 HGNC: 9317 AceView: PPP3R1andC1DandLOC116143 Ensembl:ENSG00000221823 euGenes: HUgn5534
    ECgene: PPP3R1 Kegg: 5534 H-InvDB: PPP3R1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP3R1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP3R1 gene:
    Search GeneIP for patents involving PPP3R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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