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Aliases for PPP3R1 Gene

Aliases for PPP3R1 Gene

  • Protein Phosphatase 3, Regulatory Subunit B, Alpha 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Alpha Isoform (Calcineurin B, Type I) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Alpha Isoform (Calcineurin B, Type I) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Alpha Isoform 2 3
  • Protein Phosphatase 2B Regulatory Subunit B Alpha 2 3
  • Protein Phosphatase 2B Regulatory Subunit 1 3 4
  • CNB 3 4
  • Protein Phosphatase 3 Regulatory Subunit B Alpha Isoform 1 4
  • Calcineurin B, Type I (19kDa) 3
  • Type I (19kDa) 2
  • Calcineurin B 2
  • CALNB1 3
  • CNA2 4
  • CNB1 3

External Ids for PPP3R1 Gene

Previous GeneCards Identifiers for PPP3R1 Gene

  • GC02M068539
  • GC02M068363
  • GC02M068324
  • GC02M068380
  • GC02M068261
  • GC02M068317
  • GC02M068259
  • GC02M068358
  • GC02M068405

Summaries for PPP3R1 Gene

GeneCards Summary for PPP3R1 Gene

PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, Alpha) is a Protein Coding gene. Diseases associated with PPP3R1 include cervical neuroblastoma and extracranial neuroblastoma. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for PPP3R1 Gene

  • Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity

Gene Wiki entry for PPP3R1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3R1 Gene

Genomics for PPP3R1 Gene

Regulatory Elements for PPP3R1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP3R1 Gene

Chromosome:
2
Start:
68,178,857 bp from pter
End:
68,256,237 bp from pter
Size:
77,381 bases
Orientation:
Minus strand

Genomic View for PPP3R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP3R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3R1 Gene

Proteins for PPP3R1 Gene

  • Protein details for PPP3R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63098-CANB1_HUMAN
    Recommended name:
    Calcineurin subunit B type 1
    Protein Accession:
    P63098
    Secondary Accessions:
    • B2RC10
    • B5MDU4
    • P06705
    • P15117
    • Q08044
    • Q53SL0

    Protein attributes for PPP3R1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19300 Da
    Quaternary structure:
    • Interacts with CIB1 (via C-terminal region); the interaction increases upon cardiomyocytes hypertrophy (By similarity). Composed of a catalytic subunit (A) and a regulatory subunit (B).
    Miscellaneous:
    • This protein has four functional calcium-binding sites

    Three dimensional structures from OCA and Proteopedia for PPP3R1 Gene

neXtProt entry for PPP3R1 Gene

Proteomics data for PPP3R1 Gene at MOPED

Post-translational modifications for PPP3R1 Gene

  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP3R1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PPP3R1 (Calcineurin B)
  • Cloud-Clone Corp. Antibodies for PPP3R1

No data available for DME Specific Peptides for PPP3R1 Gene

Domains & Families for PPP3R1 Gene

Suggested Antigen Peptide Sequences for PPP3R1 Gene

Graphical View of Domain Structure for InterPro Entry

P63098

UniProtKB/Swiss-Prot:

CANB1_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the calcineurin regulatory subunit family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calcineurin regulatory subunit family.
genes like me logo Genes that share domains with PPP3R1: view

Function for PPP3R1 Gene

Molecular function for PPP3R1 Gene

GENATLAS Biochemistry:
calcineurin B,calmodulin dependent protein serine/threonine phosphatase 3,regulatory subunit
UniProtKB/Swiss-Prot Function:
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity

Gene Ontology (GO) - Molecular Function for PPP3R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity NAS 2558868
GO:0005509 calcium ion binding NAS 2558868
GO:0005515 protein binding IPI 8524402
GO:0005516 calmodulin binding NAS 2558868
GO:0019904 protein domain specific binding IPI 20639889
genes like me logo Genes that share ontologies with PPP3R1: view
genes like me logo Genes that share phenotypes with PPP3R1: view

Animal Models for PPP3R1 Gene

MGI Knock Outs for PPP3R1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP3R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PPP3R1 Gene

Localization for PPP3R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP3R1 Gene

Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocytes hypertrophy. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP3R1 Gene COMPARTMENTS Subcellular localization image for PPP3R1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PPP3R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005955 calcineurin complex NAS 2558868
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with PPP3R1: view

Pathways & Interactions for PPP3R1 Gene

genes like me logo Genes that share pathways with PPP3R1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epithelial to Mesenchymal Transition (EMT) in human,mouse,rat
    • VEGF Signaling in human,mouse,rat

Gene Ontology (GO) - Biological Process for PPP3R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006470 protein dephosphorylation NAS 2558868
GO:0006915 apoptotic process TAS --
GO:0012501 programmed cell death TAS --
GO:0033173 calcineurin-NFAT signaling cascade IDA 22688515
genes like me logo Genes that share ontologies with PPP3R1: view

No data available for SIGNOR curated interactions for PPP3R1 Gene

Drugs & Compounds for PPP3R1 Gene

(7) Drugs for PPP3R1 Gene - From: ApexBio, DrugBank, NovoSeek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational Pharma Immunosuppressant drug 0
Pimecrolimus Approved, Investigational Pharma 60
Tacrolimus Approved, Investigational Pharma 992
MYRISTIC ACID Experimental Pharma Target 0
ISA247 Investigational Pharma Target 0
genes like me logo Genes that share compounds with PPP3R1: view

Transcripts for PPP3R1 Gene

mRNA/cDNA for PPP3R1 Gene

Unigene Clusters for PPP3R1 Gene

Protein phosphatase 3, regulatory subunit B, alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP3R1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3R1 Gene

No ASD Table

Relevant External Links for PPP3R1 Gene

GeneLoc Exon Structure for
PPP3R1
ECgene alternative splicing isoforms for
PPP3R1

Expression for PPP3R1 Gene

mRNA expression in normal human tissues for PPP3R1 Gene

mRNA differential expression in normal tissues according to GTEx for PPP3R1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for PPP3R1 Gene

This gene is overexpressed in Brain (24.9) and Fetal Brain (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3R1 Gene



SOURCE GeneReport for Unigene cluster for PPP3R1 Gene Hs.280604

genes like me logo Genes that share expression patterns with PPP3R1: view

Protein tissue co-expression partners for PPP3R1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PPP3R1 Gene

Orthologs for PPP3R1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP3R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP3R1 35
  • 97.06 (n)
  • 100 (a)
PPP3R1 36
  • 100 (a)
ManyToMany
WDR92 36
  • 3 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia PPP3R1 35
  • 95.46 (n)
  • 100 (a)
-- 36
  • 22 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppp3r1 35
  • 94.51 (n)
  • 100 (a)
Ppp3r1 16
Ppp3r1 36
  • 100 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PPP3R1 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Ppp3r1 35
  • 92.35 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 3 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PPP3R1 35
  • 91.18 (n)
  • 100 (a)
PPP3R1 36
  • 100 (a)
ManyToMany
WDR92 36
  • 3 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75600 35
ppp3r1 35
  • 86.08 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii nrarpa 35
ppp3r1a 35
  • 80.59 (n)
  • 99.41 (a)
ppp3r1a 36
  • 99 (a)
ManyToMany
wdr92 36
  • 2 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CanB 37
  • 85 (a)
CanB2 37
  • 87 (a)
CanB2 35
  • 72.16 (n)
  • 87.65 (a)
CG14353 36
  • 1 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004298 35
  • 70.59 (n)
  • 86.47 (a)
worm
(Caenorhabditis elegans)
Secernentea cnb-1 35
  • 68.04 (n)
  • 81.76 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER096C 35
  • 58.13 (n)
  • 57.74 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02992g 35
  • 64.3 (n)
  • 63.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 35
  • 58.76 (n)
  • 58.97 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18430 35
  • 46.1 (n)
  • 35.06 (a)
rice
(Oryza sativa)
Liliopsida Os08g0442300 35
  • 47.15 (n)
  • 34.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14820 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03833 35
  • 58.45 (n)
  • 64.49 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC830.06 35
  • 59.02 (n)
  • 57.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 3 (a)
OneToMany
Species with no ortholog for PPP3R1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3R1 Gene

ENSEMBL:
Gene Tree for PPP3R1 (if available)
TreeFam:
Gene Tree for PPP3R1 (if available)

Paralogs for PPP3R1 Gene

Paralogs for PPP3R1 Gene

Pseudogenes.org Pseudogenes for PPP3R1 Gene

genes like me logo Genes that share paralogs with PPP3R1: view

Variants for PPP3R1 Gene

Sequence variations from dbSNP and Humsavar for PPP3R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs687 -- 68,188,635(-) TTGGA(C/T)AATTC reference, synonymous-codon
rs875 -- 68,180,794(-) AACTG(A/C/T)AATTC utr-variant-3-prime
rs3504 -- 68,231,463(+) tgaat(A/G)gattt intron-variant
rs140773 -- 68,186,305(-) ATTAA(-/TTAA)CAATT intron-variant
rs140788 -- 68,231,464(-) aaatc(-/TAT)tattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3R1 Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV Loss 17160897
nsv874249 CNV Loss 21882294

Variation tolerance for PPP3R1 Gene

Residual Variation Intolerance Score: 55.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP3R1 Gene

HapMap Linkage Disequilibrium report
PPP3R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3R1 Gene

Disorders for PPP3R1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PPP3R1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervical neuroblastoma
extracranial neuroblastoma
calcaneonavicular coalition
  • synostoses, tarsal, carpal and digital
ascaridiasis
  • ascariasis
breast abscess
- elite association

Relevant External Links for PPP3R1

Genetic Association Database (GAD)
PPP3R1
Human Genome Epidemiology (HuGE) Navigator
PPP3R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP3R1
genes like me logo Genes that share disorders with PPP3R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3R1 Gene

Publications for PPP3R1 Gene

  1. Calcineurin regulates innate antifungal immunity in neutrophils. (PMID: 20421389) Greenblatt M.B. … Glimcher L.H. (J. Exp. Med. 2010) 23 67
  2. Calcineurin regulatory subunit B is a unique calcium sensor that regulates calcineurin in both calcium-dependent and calcium-independent manner. (PMID: 19536897) Li J. … Wei Q. (Proteins 2009) 23 67
  3. Overexpression of calcineurin B subunit (CnB) enhances the oncogenic potential of HEK293 cells. (PMID: 18422742) Wang Y.L. … Wei Q. (Cancer Sci. 2008) 23 67
  4. Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. (PMID: 16209992) Tang W. … Ferrell R.E. (Am. Heart J. 2005) 23 67
  5. cDNA cloning of calcineurin heterosubunits from the pheromone gland of the silkmoth, Bombyx mori. (PMID: 11886782) Yoshiga T. … Matsumoto S. (Insect Biochem. Mol. Biol. 2002) 23 67

Products for PPP3R1 Gene

Sources for PPP3R1 Gene

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