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Aliases for PPP3R1 Gene

Aliases for PPP3R1 Gene

  • Protein Phosphatase 3, Regulatory Subunit B, Alpha 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Alpha Isoform (Calcineurin B, Type I) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Alpha Isoform (Calcineurin B, Type I) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Alpha Isoform 2 3
  • Protein Phosphatase 2B Regulatory Subunit B Alpha 2 3
  • Protein Phosphatase 2B Regulatory Subunit 1 3 4
  • CALNB1 3 6
  • CNB 3 4
  • Protein Phosphatase 3 Regulatory Subunit B Alpha Isoform 1 4
  • Calcineurin B, Type I (19kDa) 3
  • Calcineurin Subunit B Type 1 3
  • Type I (19kDa) 2
  • Calcineurin B 2
  • CNA2 4
  • CNB1 3

External Ids for PPP3R1 Gene

Summaries for PPP3R1 Gene

GeneCards Summary for PPP3R1 Gene

PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, Alpha) is a Protein Coding gene. Diseases associated with PPP3R1 include calcaneonavicular coalition. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for PPP3R1 Gene

  • Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity

Gene Wiki entry for PPP3R1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3R1 Gene

Genomics for PPP3R1 Gene

Genomic Location for PPP3R1 Gene

Start:
68,178,857 bp from pter
End:
68,256,237 bp from pter
Size:
77,381 bases
Orientation:
Minus strand

Genomic View for PPP3R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP3R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3R1 Gene

Regulatory Elements for PPP3R1 Gene

Proteins for PPP3R1 Gene

  • Protein details for PPP3R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63098-CANB1_HUMAN
    Recommended name:
    Calcineurin subunit B type 1
    Protein Accession:
    P63098
    Secondary Accessions:
    • B2RC10
    • B5MDU4
    • P06705
    • P15117
    • Q08044
    • Q53SL0

    Protein attributes for PPP3R1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19300 Da
    Quaternary structure:
    • Interacts with CIB1 (via C-terminal region); the interaction increases upon cardiomyocytes hypertrophy (By similarity). Composed of a catalytic subunit (A) and a regulatory subunit (B).
    Miscellaneous:
    • This protein has four functional calcium-binding sites

    Three dimensional structures from OCA and Proteopedia for PPP3R1 Gene

neXtProt entry for PPP3R1 Gene

Proteomics data for PPP3R1 Gene at MOPED

Post-translational modifications for PPP3R1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys103 and Lys125

Other Protein References for PPP3R1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP3R1 Gene

Domains for PPP3R1 Gene

Gene Families for PPP3R1 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • PPP3R :Serine/threonine phosphatases / Protein phosphatase 3, regulatory subunits

UniProtKB/Swiss-Prot:

CANB1_HUMAN
Domain:
  • Contains 4 EF-hand domains.:
    • P63098
Family:
  • Belongs to the calcineurin regulatory subunit family.:
    • P63098
genes like me logo Genes that share domains with PPP3R1: view

Function for PPP3R1 Gene

Molecular function for PPP3R1 Gene

GENATLAS Biochemistry: calcineurin B,calmodulin dependent protein serine/threonine phosphatase 3,regulatory subunit
UniProtKB/Swiss-Prot Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity

Gene Ontology (GO) - Molecular Function for PPP3R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity NAS 2558868
GO:0005509 calcium ion binding NAS 2558868
GO:0005515 protein binding IPI 16648474
GO:0005516 calmodulin binding NAS 2558868
GO:0019904 protein domain specific binding IPI 20639889
genes like me logo Genes that share ontologies with PPP3R1: view
genes like me logo Genes that share phenotypes with PPP3R1: view

Animal Models for PPP3R1 Gene

MGI Knock Outs for PPP3R1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPP3R1 Gene

Localization for PPP3R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP3R1 Gene

Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocytes hypertrophy. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP3R1 Gene COMPARTMENTS Subcellular localization image for PPP3R1 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPP3R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005955 calcineurin complex NAS 2558868
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with PPP3R1: view

Pathways for PPP3R1 Gene

genes like me logo Genes that share pathways with PPP3R1: view

Gene Ontology (GO) - Biological Process for PPP3R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006915 apoptotic process TAS --
GO:0012501 programmed cell death TAS --
GO:0016311 dephosphorylation NAS 2558868
GO:0033173 calcineurin-NFAT signaling cascade IDA 22688515
genes like me logo Genes that share ontologies with PPP3R1: view

Compounds for PPP3R1 Gene

(1) HMDB Compounds for PPP3R1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for PPP3R1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
MYRISTIC ACID
target

(3) Novoseek inferred chemical compound relationships for PPP3R1 Gene

Compound -log(P) Hits PubMed IDs
tacrolimus 50.3 3
cyclosporin a 35.5 3
calcium 8.67 4
genes like me logo Genes that share compounds with PPP3R1: view

Transcripts for PPP3R1 Gene

mRNA/cDNA for PPP3R1 Gene

Unigene Clusters for PPP3R1 Gene

Protein phosphatase 3, regulatory subunit B, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3R1 Gene

No ASD Table

Relevant External Links for PPP3R1 Gene

GeneLoc Exon Structure for
PPP3R1
ECgene alternative splicing isoforms for
PPP3R1

Expression for PPP3R1 Gene

mRNA expression in normal human tissues for PPP3R1 Gene

mRNA differential expression in normal tissues according to GTEx for PPP3R1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3R1 Gene

SOURCE GeneReport for Unigene cluster for PPP3R1 Gene Hs.280604

genes like me logo Genes that share expressions with PPP3R1: view

Orthologs for PPP3R1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP3R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP3R1 36
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PPP3R1 36
  • 97.06 (n)
  • 100 (a)
PPP3R1 37
  • 100 (a)
ManyToMany
WDR92 37
  • 3 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 22 (a)
OneToMany
PPP3R1 36
  • 95.46 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Ppp3r1 36
  • 94.51 (n)
  • 100 (a)
Ppp3r1 16
Ppp3r1 37
  • 100 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 98 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 3 (a)
ManyToMany
-- 37
  • 94 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ppp3r1 36
  • 92.35 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves PPP3R1 36
  • 91.18 (n)
  • 100 (a)
PPP3R1 37
  • 100 (a)
ManyToMany
WDR92 37
  • 3 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 23 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75600 36
ppp3r1 36
  • 86.08 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii nrarpa 36
ppp3r1a 36
  • 80.59 (n)
  • 99.41 (a)
ppp3r1a 37
  • 99 (a)
ManyToMany
wdr92 37
  • 2 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004298 36
  • 70.59 (n)
  • 86.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CanB2 36
  • 72.16 (n)
  • 87.65 (a)
CG14353 37
  • 1 (a)
OneToMany
CanB2 38
  • 87 (a)
CanB 38
  • 85 (a)
worm
(Caenorhabditis elegans)
Secernentea cnb-1 36
  • 68.04 (n)
  • 81.76 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER096C 36
  • 58.13 (n)
  • 57.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 36
  • 58.76 (n)
  • 58.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02992g 36
  • 64.3 (n)
  • 63.83 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18430 36
  • 46.1 (n)
  • 35.06 (a)
rice
(Oryza sativa)
Liliopsida Os08g0442300 36
  • 47.15 (n)
  • 34.21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03833 36
  • 58.45 (n)
  • 64.49 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC830.06 36
  • 59.02 (n)
  • 57.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14820 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 3 (a)
OneToMany
Species with no ortholog for PPP3R1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3R1 Gene

ENSEMBL:
Gene Tree for PPP3R1 (if available)
TreeFam:
Gene Tree for PPP3R1 (if available)

Paralogs for PPP3R1 Gene

Paralogs for PPP3R1 Gene

Pseudogenes.org Pseudogenes for PPP3R1 Gene

genes like me logo Genes that share paralogs with PPP3R1: view

Variants for PPP3R1 Gene

Sequence variations from dbSNP and Humsavar for PPP3R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs687 -- 68,188,635(-) TTGGA(C/T)AATTC reference, synonymous-codon
rs875 -- 68,180,794(-) AACTG(A/C/T)AATTC utr-variant-3-prime
rs3504 -- 68,231,463(+) tgaat(A/G)gattt intron-variant
rs140773 -- 68,186,305(-) ATTAA(-/TTAA)CAATT intron-variant
rs140788 -- 68,231,464(-) aaatc(-/TAT)tattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3R1 Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV Loss 17160897
nsv874249 CNV Loss 21882294

Relevant External Links for PPP3R1 Gene

HapMap Linkage Disequilibrium report
PPP3R1

Disorders for PPP3R1 Gene

(1) University of Copenhagen DISEASES for PPP3R1 Gene

Relevant External Links for PPP3R1

Genetic Association Database (GAD)
PPP3R1
Human Genome Epidemiology (HuGE) Navigator
PPP3R1
genes like me logo Genes that share disorders with PPP3R1: view

No data available for UniProtKB/Swiss-Prot for PPP3R1 Gene

Publications for PPP3R1 Gene

  1. Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. (PMID: 16209992) Tang W. … Ferrell R.E. (Am. Heart J. 2005) 3 23 49
  2. Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. (PMID: 2558868) Guerini D. … Klee C.B. (DNA 1989) 2 3 4
  3. Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15). (PMID: 10520753) Stratakis C.A. … Taymans S.E. (DNA Seq. 1998) 3 23
  4. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. (PMID: 12218175) Huai Q. … Ke H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  5. Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. (PMID: 12357034) Jin L. … Harrison S.C. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4

Products for PPP3R1 Gene

Sources for PPP3R1 Gene

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