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Aliases for PPP3CC Gene

Aliases for PPP3CC Gene

  • Protein Phosphatase 3 Catalytic Subunit Gamma 2 3
  • Protein Phosphatase 3, Catalytic Subunit, Gamma Isozyme 2 3 5
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Gamma Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Gamma Isoform 3 4
  • Calcineurin, Testis-Specific Catalytic Subunit 3 4
  • CAM-PRP Catalytic Subunit 3 4
  • EC 4 63
  • CALNA3 3 4
  • CNA3 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Gamma Isoform (Calcineurin A Gamma) 2
  • Protein Phosphatase 2B, Catalytic Subunit, Gamma Isoform 3
  • Protein Phosphatase 2B 2
  • Calcineurin A Gamma 2
  • Catalytic Subunit 2
  • Gamma Isoform 2
  • PP2Bgamma 3

External Ids for PPP3CC Gene

Previous GeneCards Identifiers for PPP3CC Gene

  • GC08M022210
  • GC08P022650
  • GC08P022118
  • GC08P022320
  • GC08P022354
  • GC08P022298
  • GC08P020840

Summaries for PPP3CC Gene

Entrez Gene Summary for PPP3CC Gene

  • Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for PPP3CC Gene

PPP3CC (Protein Phosphatase 3 Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PPP3CC include Schizophrenia. Among its related pathways are Axon guidance and HTLV-I infection. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP3CB.

UniProtKB/Swiss-Prot for PPP3CC Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Gene Wiki entry for PPP3CC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CC Gene

Genomics for PPP3CC Gene

Regulatory Elements for PPP3CC Gene

Enhancers for PPP3CC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP3CC on UCSC Golden Path with GeneCards custom track

Promoters for PPP3CC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP3CC on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP3CC Gene

22,440,819 bp from pter
22,541,144 bp from pter
100,326 bases
Plus strand

Genomic View for PPP3CC Gene

Genes around PPP3CC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3CC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3CC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CC Gene

Proteins for PPP3CC Gene

  • Protein details for PPP3CC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
    Protein Accession:
    Secondary Accessions:
    • B4DRT5
    • Q9BSS6
    • Q9H4M5

    Protein attributes for PPP3CC Gene

    512 amino acids
    Molecular mass:
    58129 Da
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

    Alternative splice isoforms for PPP3CC Gene


neXtProt entry for PPP3CC Gene

Proteomics data for PPP3CC Gene at MOPED

Post-translational modifications for PPP3CC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PPP3CC Gene

Gene Families for PPP3CC Gene

Suggested Antigen Peptide Sequences for PPP3CC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PPP phosphatase family. PP-2B subfamily.
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CC: view

Function for PPP3CC Gene

Molecular function for PPP3CC Gene

GENATLAS Biochemistry:
calcineurin gamma isoform,calmodulin dependent protein serine/threonine phosphatase,catalytic subunit,type 3,testis specific
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Enzyme Numbers (IUBMB) for PPP3CC Gene

Gene Ontology (GO) - Molecular Function for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP3CC: view
genes like me logo Genes that share phenotypes with PPP3CC: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP3CC Gene

Localization for PPP3CC Gene

Subcellular locations from

Jensen Localization Image for PPP3CC Gene COMPARTMENTS Subcellular localization image for PPP3CC gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
golgi apparatus 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP3CC Gene

Pathways & Interactions for PPP3CC Gene

genes like me logo Genes that share pathways with PPP3CC: view

SIGNOR curated interactions for PPP3CC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012501 programmed cell death TAS --
GO:0097193 intrinsic apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with PPP3CC: view

Drugs & Compounds for PPP3CC Gene

(4) Drugs for PPP3CC Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational Pharma Immunosuppressant drug 0
Pimecrolimus Approved, Investigational Pharma 61
Voclosporin Pharma inhibitor 0
calcium Nutra 0

(3) Additional Compounds for PPP3CC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam

(2) ApexBio Compounds for PPP3CC Gene

Compound Action Cas Number
Cyclosporine Immunosuppressant drug 79217-60-0
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3CC: view

Transcripts for PPP3CC Gene

Unigene Clusters for PPP3CC Gene

Protein phosphatase 3, catalytic subunit, gamma isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CC Gene

No ASD Table

Relevant External Links for PPP3CC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP3CC Gene

mRNA expression in normal human tissues for PPP3CC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP3CC Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for PPP3CC Gene

This gene is overexpressed in Brain (13.0), Testis (11.2), Lymph node (9.3), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3CC Gene

SOURCE GeneReport for Unigene cluster for PPP3CC Gene Hs.731683

mRNA Expression by UniProt/SwissProt for PPP3CC Gene

Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with PPP3CC: view

Protein tissue co-expression partners for PPP3CC Gene

- Elite partner

Primer Products

Orthologs for PPP3CC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP3CC 35
  • 92.02 (n)
  • 94.16 (a)
  • 91 (a)
(Canis familiaris)
Mammalia PPP3CC 35
  • 91.55 (n)
  • 92.71 (a)
  • 90 (a)
(Mus musculus)
Mammalia Ppp3cc 35
  • 86.51 (n)
  • 87.43 (a)
Ppp3cc 16
Ppp3cc 36
  • 86 (a)
(Pan troglodytes)
Mammalia PPP3CC 35
  • 99.62 (n)
  • 99.42 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ppp3cc 35
  • 87.46 (n)
  • 87.33 (a)
(Monodelphis domestica)
Mammalia PPP3CC 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PPP3CC 36
  • 87 (a)
(Anolis carolinensis)
Reptilia PPP3CC 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp3cb 35
  • 74.6 (n)
  • 83.33 (a)
(Danio rerio)
Actinopterygii ppp3cca 35
  • 74.47 (n)
  • 83.54 (a)
ppp3cca 36
  • 80 (a)
ppp3ccb 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CanA-14F 37
  • 76 (a)
CanA1 37
  • 70 (a)
Pp2B-14D 37
  • 74 (a)
PpD33 37
  • 76 (a)
CanA-14F 36
  • 64 (a)
CanA1 36
  • 58 (a)
Pp2B-14D 36
  • 66 (a)
(Caenorhabditis elegans)
Secernentea F42G8.8 37
  • 32 (a)
F49E11.7 37
  • 32 (a)
ZC477.2 37
  • 33 (a)
tax-6 36
  • 64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMP2 36
  • 44 (a)
CNA1 36
  • 47 (a)
CNA1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8703 36
  • 66 (a)
Species with no ortholog for PPP3CC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CC Gene

Gene Tree for PPP3CC (if available)
Gene Tree for PPP3CC (if available)

Paralogs for PPP3CC Gene

Paralogs for PPP3CC Gene

(10) SIMAP similar genes for PPP3CC Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP3CC: view

Variants for PPP3CC Gene

Sequence variations from dbSNP and Humsavar for PPP3CC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs28764007 - 22,540,765(+) TGCTG(C/T)GCACA downstream-variant-500B, reference, missense
rs2100291 -- 22,517,038(-) agggt(A/G)aagtt intron-variant
rs2122878 -- 22,454,403(+) aatac(C/T)tcctg intron-variant
rs2122879 -- 22,484,113(+) aagtg(C/T)tagga intron-variant
rs2122880 -- 22,517,529(-) GAGAT(G/T)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3CC Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv518646 CNV Gain 19592680
nsv831266 CNV Loss 17160897
essv1932 CNV CNV 17122850
dgv451n21 CNV Loss 19592680
nsv890672 CNV Loss 21882294

Variation tolerance for PPP3CC Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP3CC Gene

Disorders for PPP3CC Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP3CC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP3CC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPP3CC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CC Gene

Publications for PPP3CC Gene

  1. Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). (PMID: 1339277) Muramatsu T. … Kincaid R.L. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 67
  2. Association between the PPP3CC gene, coding for the calcineurin gamma catalytic subunit, and bipolar disorder. (PMID: 18201382) Mathieu F. … Tzavara E.T. (Behav Brain Funct 2008) 3 23
  3. Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer. (PMID: 18460741) Hornstein M. … Schulz W.A. (Cancer Genomics Proteomics 2008) 3 23
  4. More evidence supports the association of PPP3CC with schizophrenia. (PMID: 17339875) Liu Y.L. … Hwu H.G. (Mol. Psychiatry 2007) 3 23
  5. Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. (PMID: 15820226) Eastwood S.L. … Harrison P.J. (Biol. Psychiatry 2005) 3 23

Products for PPP3CC Gene

Sources for PPP3CC Gene