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Aliases for PPP3CC Gene

Aliases for PPP3CC Gene

  • Protein Phosphatase 3 Catalytic Subunit Gamma 2 3 5
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Gamma Isoform 2 3
  • Protein Phosphatase 2B, Catalytic Subunit, Gamma Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Gamma Isoform 3 4
  • Protein Phosphatase 3, Catalytic Subunit, Gamma Isozyme 2 3
  • Calcineurin, Testis-Specific Catalytic Subunit 3 4
  • CAM-PRP Catalytic Subunit 3 4
  • EC 3.1.3.16 4 61
  • CALNA3 3 4
  • CNA3 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Gamma Isoform (Calcineurin A Gamma) 2
  • Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Gamma Isoform 3
  • Calcineurin A Gamma 2
  • PP2Bgamma 3

External Ids for PPP3CC Gene

Previous GeneCards Identifiers for PPP3CC Gene

  • GC08M022210
  • GC08P022650
  • GC08P022118
  • GC08P022320
  • GC08P022354
  • GC08P022298
  • GC08P020840

Summaries for PPP3CC Gene

Entrez Gene Summary for PPP3CC Gene

  • Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for PPP3CC Gene

PPP3CC (Protein Phosphatase 3 Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PPP3CC include Schizophrenia. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP3CB.

UniProtKB/Swiss-Prot for PPP3CC Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Gene Wiki entry for PPP3CC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CC Gene

Genomics for PPP3CC Gene

Regulatory Elements for PPP3CC Gene

Enhancers for PPP3CC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G022439 2 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +3.8 3847 10.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A ZNF2 ENSG00000253200 PPP3CC C8orf58 SORBS3 POLR3D LOC100507071 BIN3 ENSG00000251034 PDLIM2 ENSG00000248235
GH08G022363 2 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -73.2 -73177 8.3 HDGF HNRNPUL1 FOXA2 PKNOX1 MLX CREB3L1 ARNT ZFP64 SIN3A ARID4B PIWIL2 PPP3CC SLC39A14 PDLIM2 ENSG00000248235 RNU6-336P ENSG00000253616 BTF3P3 POLR3D DMTN
GH08G022537 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.6 +99.6 99611 6.0 PKNOX1 FEZF1 RAD21 ZNF335 ZNF121 ZSCAN5C FOS KLF7 PAF1 CEBPB PPP3CC RNU6-336P PDLIM2 ENSG00000248235 SORBS3 GC08M022506
GH08G022545 1.7 FANTOM5 ENCODE dbSUPER 18.5 +109.4 109365 10.0 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 FOS PAF1 PPP3CC SORBS3 RNU6-336P PDLIM2 ENSG00000248235 ENSG00000253200 SLC39A14 LGI3 DMTN PHYHIP
GH08G022409 1.1 ENCODE dbSUPER 27 -29.6 -29633 2.9 TBP MLX RAD21 RARA YY1 PAF1 ZNF680 MXD4 NFYC PPARG PPP3CC RNU6-336P C8orf58 PDLIM2 ENSG00000248235 GC08M022420 RPL21P77
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP3CC on UCSC Golden Path with GeneCards custom track

Promoters for PPP3CC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222059 1081 2601 HDGF MLX CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143

Genomic Location for PPP3CC Gene

Chromosome:
8
Start:
22,440,819 bp from pter
End:
22,541,144 bp from pter
Size:
100,326 bases
Orientation:
Plus strand

Genomic View for PPP3CC Gene

Genes around PPP3CC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3CC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3CC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CC Gene

Proteins for PPP3CC Gene

  • Protein details for PPP3CC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48454-PP2BC_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
    Protein Accession:
    P48454
    Secondary Accessions:
    • B4DRT5
    • Q9BSS6
    • Q9H4M5

    Protein attributes for PPP3CC Gene

    Size:
    512 amino acids
    Molecular mass:
    58129 Da
    Cofactor:
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

    Alternative splice isoforms for PPP3CC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP3CC Gene

Selected DME Specific Peptides for PPP3CC Gene

P48454:
  • DLLWSDP
  • LLRGNHECRHLT
  • GVLSGGKQT
  • APITVCGD
  • ICSDDEL
  • NKIRAIGKMARVF
  • NERMPPR
  • TIFSAPNY
  • VRGCSYF
  • DIRKLDRF
  • PHPYWLP
  • CGDIHGQ
  • TGFPSLIT
  • NKAAVLKYE
  • GYRMYRK
  • GDYVDRG
  • VDVLKNHLVKEGR
  • NVMNIRQF
  • KLFEVGG
  • LKGLTPTG
  • EPPAFGP
  • FMDVFTWSLPFVGEKVTEMLV
  • LLSIIRAHEAQDAGYRMY
  • KAVPFPP
  • EKTMIEV
  • IRNKIRAIGKM

Post-translational modifications for PPP3CC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PPP3CC Gene

Gene Families for PPP3CC Gene

Suggested Antigen Peptide Sequences for PPP3CC Gene

Graphical View of Domain Structure for InterPro Entry

P48454

UniProtKB/Swiss-Prot:

PP2BC_HUMAN :
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CC: view

Function for PPP3CC Gene

Molecular function for PPP3CC Gene

GENATLAS Biochemistry:
calcineurin gamma isoform,calmodulin dependent protein serine/threonine phosphatase,catalytic subunit,type 3,testis specific
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Enzyme Numbers (IUBMB) for PPP3CC Gene

Gene Ontology (GO) - Molecular Function for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005516 calmodulin binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP3CC: view
genes like me logo Genes that share phenotypes with PPP3CC: view

Animal Models for PPP3CC Gene

MGI Knock Outs for PPP3CC:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3CC Gene

Localization for PPP3CC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP3CC gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 4
plasma membrane 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PPP3CC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP3CC Gene

Pathways & Interactions for PPP3CC Gene

genes like me logo Genes that share pathways with PPP3CC: view

SIGNOR curated interactions for PPP3CC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007420 brain development IEA --
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with PPP3CC: view

Drugs & Compounds for PPP3CC Gene

(6) Drugs for PPP3CC Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
Pimecrolimus Approved, Investigational Pharma 63
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Voclosporin Pharma inhibitor 0

(1) Additional Compounds for PPP3CC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(2) ApexBio Compounds for PPP3CC Gene

Compound Action Cas Number
Cyclosporine Immunosuppressant drug 79217-60-0
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3CC: view

Drug Products

Transcripts for PPP3CC Gene

Unigene Clusters for PPP3CC Gene

Protein phosphatase 3, catalytic subunit, gamma isozyme:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CC Gene

No ASD Table

Relevant External Links for PPP3CC Gene

GeneLoc Exon Structure for
PPP3CC
ECgene alternative splicing isoforms for
PPP3CC

Expression for PPP3CC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP3CC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP3CC Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for PPP3CC Gene

This gene is overexpressed in Brain (13.0), Testis (11.2), Lymph node (9.3), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP3CC Gene



Protein tissue co-expression partners for PPP3CC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP3CC Gene:

PPP3CC

SOURCE GeneReport for Unigene cluster for PPP3CC Gene:

Hs.731683

mRNA Expression by UniProt/SwissProt for PPP3CC Gene:

P48454-PP2BC_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for PPP3CC Gene

  • Heart(4.3)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with PPP3CC: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3CC Gene

Orthologs for PPP3CC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP3CC 34 35
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia PPP3CC 34 35
  • 92.02 (n)
dog
(Canis familiaris)
Mammalia PPP3CC 34 35
  • 91.55 (n)
rat
(Rattus norvegicus)
Mammalia Ppp3cc 34
  • 87.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP3CC 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp3cc 34 16 35
  • 86.51 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP3CC 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP3CC 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp3cb 34
  • 74.6 (n)
zebrafish
(Danio rerio)
Actinopterygii ppp3ccb 35
  • 81 (a)
OneToMany
ppp3cca 34 35
  • 74.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CanA-14F 36 35
  • 76 (a)
PpD33 36
  • 76 (a)
Pp2B-14D 36 35
  • 74 (a)
CanA1 36 35
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea tax-6 35
  • 64 (a)
OneToMany
ZC477.2 36
  • 33 (a)
F42G8.8 36
  • 32 (a)
F49E11.7 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNA1 35 37
  • 47 (a)
ManyToMany
CMP2 35
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8703 35
  • 66 (a)
OneToMany
Species where no ortholog for PPP3CC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CC Gene

ENSEMBL:
Gene Tree for PPP3CC (if available)
TreeFam:
Gene Tree for PPP3CC (if available)

Paralogs for PPP3CC Gene

Paralogs for PPP3CC Gene

(10) SIMAP similar genes for PPP3CC Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP3CC: view

Variants for PPP3CC Gene

Sequence variations from dbSNP and Humsavar for PPP3CC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000005555 -- 22,448,047(+) ATTTG(A/G)AGAAT intron-variant
rs1000008614 -- 22,508,949(+) CTCCT(A/G)ATAAA intron-variant
rs1000045710 -- 22,455,130(+) TTCCT(C/T)TTCTA intron-variant
rs1000061864 -- 22,475,436(+) CCTTT(C/T)GGTGT intron-variant
rs1000122709 -- 22,470,327(+) GCTAT(C/G)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3CC Gene

Variant ID Type Subtype PubMed ID
dgv451n21 CNV loss 19592680
dgv7136n100 CNV gain 25217958
dgv7137n100 CNV loss 25217958
esv2759604 CNV loss 17122850
esv2764071 CNV gain 21179565
esv3543215 CNV deletion 23714750
esv3616610 CNV loss 21293372
esv3616612 CNV loss 21293372
nsv518646 CNV gain 19592680
nsv831266 CNV loss 17160897
nsv971631 CNV duplication 23825009

Variation tolerance for PPP3CC Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP3CC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP3CC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3CC Gene

Disorders for PPP3CC Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP3CC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP3CC

Genetic Association Database (GAD)
PPP3CC
Human Genome Epidemiology (HuGE) Navigator
PPP3CC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP3CC
genes like me logo Genes that share disorders with PPP3CC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CC Gene

Publications for PPP3CC Gene

  1. More evidence supports the association of PPP3CC with schizophrenia. (PMID: 17339875) Liu Y.L. … Hwu H.G. (Mol. Psychiatry 2007) 3 22 46 64
  2. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. (PMID: 12851458) Gerber D.J. … Tonegawa S. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 22 46 64
  3. Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). (PMID: 1339277) Muramatsu T. … Kincaid R.L. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 64
  4. Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PMID: 20537399) Kyogoku C. … Kumagai S. (Psychiatry Res 2011) 3 46 64
  5. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So H.C. … Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64

Products for PPP3CC Gene

Sources for PPP3CC Gene

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