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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP3CA Gene

protein-coding   GIFtS: 72
GCID: GC04M101944

Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme

(Previous names: protein phosphatase 3 (formerly 2B), catalytic subunit,...)
(Previous symbols: CALN, CALNA)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme1 2     Alpha Isoform1
CALNA1 2 3 5     Catalytic Subunit1
CALN1 2     Protein Phosphatase 2B1
Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform1 2     Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform
(Calcineurin A Alpha)1
Calcineurin A Alpha1 2     CALNA12
Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform2 3     CCN12
CAM-PRP Catalytic Subunit2 3     Protein Phosphatase 2B, Catalytic Subunit, Alpha Isoform2
EC 3.1.3.163 8     Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Alpha Isoform2
CNA12 5     CNA3
PPP2B2 5     

External Ids:    HGNC: 93141   Entrez Gene: 55302   Ensembl: ENSG000001388147   OMIM: 1141055   UniProtKB: Q082093   

Export aliases for PPP3CA gene to outside databases

Previous GC identifers: GC04M102343 GC04M102402 GC04M102301 GC04M102163 GC04M097682


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPP3CA Gene: 
PPP3CA (protein phosphatase 3, catalytic subunit, alpha isozyme) is a protein-coding gene. Diseases associated with PPP3CA include osteomyelitis, and down syndrome critical region, and among its related super-pathways are Fc epsilon RI signaling pathway and BCR signaling pathway. GO annotations related to this gene include enzyme binding and calcium ion binding. An important paralog of this gene is PPP3CC.

UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209
Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the
calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1

Gene Wiki entry for PPP3CA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP3CA gene promoter:
         AML1a   GATA-3   MyoD   Meis-1b   HNF-1A   Evi-1   HNF-1   Meis-1a   ZIC2/Zic2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP3CA promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP3CA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP3CA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

PPP3CA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP3CA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M101944:  view genomic region     (about GC identifiers)

Start:
101,944,566 bp from pter      End:
102,269,435 bp from pter
Size:
324,870 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform  
Size: 521 amino acids; 58688 Da
Cofactor: Binds 1 Fe(3+) ion per subunit
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is
the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and
MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to
mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity)
Subcellular location: Nucleus (By similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and
skeletal muscle (By similarity)
6/10 PDB 3D structures from and Proteopedia for PPP3CA (see all 10):
1AUI (3D)        1M63 (3D)        1MF8 (3D)        2JOG (3D)        2JZI (3D)        2P6B (3D)    
Secondary accessions: A8K3B7 A8W6Z7 B5BUA2 Q8TAW9
Alternative splicing: 3 isoforms:  Q08209-1   Q08209-2   Q08209-3   

Explore the universe of human proteins at neXtProt for PPP3CA: NX_Q08209

Explore proteomics data for PPP3CA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08209

  • 4/26 DME Specific Peptides for PPP3CA (Q08209) (see all 26)
     KLFEVGG  PHPYWLP  CGDIHGQ  DRFKEPP 

    PPP3CA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP3CA Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000935.1  NP_001124163.1  NP_001124164.1  

    ENSEMBL proteins: 
     ENSP00000422781   ENSP00000378323   ENSP00000320580   ENSP00000378322   ENSP00000422990  
     ENSP00000426565   ENSP00000431619   ENSP00000434599   ENSP00000429350  
    Reactome Protein details: Q08209
    Human Recombinant Protein Products for PPP3CA: 
    EMD Millipore Purified and/or Recombinant PPP3CA Protein
    R&D Systems Recombinant & Natural Proteins for PPP3CA (Calcineurin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PPP3CA
    GenScript Custom Purified and Recombinant Proteins Services for PPP3CA
    Novus Biologicals PPP3CA Proteins
    Sino Biological Recombinant Protein for PPP3CA
    Sino Biological Cell Lysate for PPP3CA 
    ProSpec Recombinant Protein for PPP3CA
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    PPP3CA for ontologies           About GeneDecksing



    PPP3CA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP3CA
    R&D Systems Antibodies for PPP3CA (Calcineurin A)
    OriGene Antibodies for PPP3CA
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    GenScript Custom Superior Antibodies Services for PPP3CA
    Novus Biologicals PPP3CA Antibodies
    Abcam antibodies for PPP3CA
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for PPP3CA
    LSBio Antibodies in human, mouse, rat for PPP3CA 

    Assay Products for PPP3CA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP3CA
    R&D Systems Kinase Activity Assays & Reagents for PPP3CA (Calcineurin)
    GenScript Custom Assay Services for PPP3CA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 Metallo_PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry Q08209

    ProtoNet protein and cluster: Q08209

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209
    Similarity: Belongs to the PPP phosphatase family. PP-2B subfamily


    PPP3CA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP2BA_HUMAN, Q08209
    Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the
    calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for PPP3CA:
    calcineurin A alpha isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,58-59kDa,also
    abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity NAS8392375
    GO:0004723calcium-dependent protein serine/threonine phosphatase activity ----
    GO:0005509calcium ion binding NAS8392375
    GO:0005515protein binding IPI11114196
         
    PPP3CA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPP3CA:
     Decreased focal adhesion (FA)   Synthetic lethal with imatinib  Synthetic lethal with paclitax 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp3ca):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  nervous system  renal/urinary system 

    PPP3CA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp3catm1Jse for PPP3CA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP3CA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP3CA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP3CA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP3CA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP3CA:
    hsa-mir-145 (MIRT000677), hsa-mir-30a (MIRT005198)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP3CA
    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP3CA (see all 104):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-632 hsa-miR-30d hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP3CA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP3CA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP3CA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP3CA
    Sirion Biotech Customized adenovirus for overexpression of PPP3CA

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PPP3CA (see all 15)
    OriGene ORF clones in mouse, rat for PPP3CA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPP3CA (NM_000944)
    Sino Biological Human cDNA Clone for PPP3CA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP3CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3CA
    Sirion Biotech Customized lentivirus for stable overexpression of PPP3CA 
                         Customized lentivirus expression plasmids for stable overexpression of PPP3CA 

    Cell Line
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    Search LifeMap BioReagents cell lines for PPP3CA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3CA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP3CA About   (see all 57)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Immune response CD16 signaling in NK cells0.32
    Immune response BCR pathway0.45
    Natural killer cell mediated cytotoxicity0.31
    VEGF signaling pathway0.39
    2B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    3Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40
    4fMLP Pathway
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/18 EMD Millipore Pathways for PPP3CA (see all 18)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Immune response CD16 signaling in NK cells
    Immune response IL-2 activation and signaling pathway
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Immune response Function of MEF2 in T lymphocytes

    2 R&D Systems Pathways for PPP3CA
        Wnt Signaling Pathway
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP3CA (see all 33)
        14-3-3 Induced Apoptosis
    Intracellular Calcium Signaling
    PI3K Signaling in B-Lymphocyte
    IL-2 Pathway
    ITK and TCR Signaling

    5/20 GeneGo (Thomson Reuters) Pathways for PPP3CA (see all 20)
        Signal transduction cAMP signaling
    Immune response CD28 signaling
    Immune response CD16 signaling in NK cells
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/9 BioSystems Pathways for PPP3CA (see all 9)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    G Protein Signaling Pathways
    Spinal Cord Injury
    Energy Metabolism


    5/8        Reactome Pathways for PPP3CA (see all 8)
        Signaling by GPCR
    Opioid Signalling
    DARPP-32 events
    Signal Transduction
    Fc epsilon receptor (FCERI) signaling

    1 PharmGKB Pathway for PPP3CA
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/19         Kegg Pathways  (Kegg details for PPP3CA) (see all 19):
        MAPK signaling pathway
    Calcium signaling pathway
    Oocyte meiosis
    Apoptosis
    Wnt signaling pathway


    PPP3CA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP3CA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/187 Interacting proteins for PPP3CA (Q082091, 2, 3 ENSP000003783234) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-352922,EBI-401755 MINT-8256591 I2D: score=5 STRING: ENSP00000339007
    PPP3R1P630982, 3, ENSP000002343104MINT-7296006 I2D: score=9 STRING: ENSP00000234310
    ENSG00000206289P287023I2D: score=1 
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006470protein dephosphorylation NAS8392375
    GO:0006606protein import into nucleus IEA--
    GO:0006816calcium ion transport IEA--

    PPP3CA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP3CA for compounds           About GeneDecksing

    EMD Millipore small molecules for PPP3CA:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP3CA (PP2BA)

    3 HMDB Compounds for PPP3CA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PPP3CA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --target--10592235

    5 Novoseek inferred chemical compound relationships for PPP3CA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enterotoxin 44.9 1 15741366 (1)
    tacrolimus 44.8 4 18172213 (1), 8880916 (1)
    cyclosporin a 29.1 2 12639710 (1)
    calcium 19.7 3 17339875 (1), 18187190 (1), 12764228 (1)
    fibrinogen 7.72 2 17133904 (1), 10463169 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP3CA / PP2BA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP3CA gene (3 alternative transcripts): 
    NM_000944.4  NM_001130691.1  NM_001130692.1  

    Unigene Cluster for PPP3CA:

    Protein phosphatase 3, catalytic subunit, alpha isozyme
    Hs.435512  [show with all ESTs]
    Unigene Representative Sequence: NM_000944
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512215(uc010ilk.2) ENST00000394854(uc011cen.1 uc003hvu.2 uc010ilj.2 uc003hvt.2 uc003hvs.2)
    ENST00000323055 ENST00000394853 ENST00000507176 ENST00000492351 ENST00000510292
    ENST00000529324 ENST00000525819 ENST00000523694

    miRNA
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    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP3CA (see all 104):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-632 hsa-miR-30d hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP3CA 3' UTR sequence
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP3CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3CA
    Sirion Biotech Customized lentivirus for stable overexpression of PPP3CA 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP3CA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP3CA

    Additional mRNA sequence: 

    AB451338.1 AB451487.1 AK290532.1 AL353950.1 AY904364.1 BC025714.1 BC098424.1 EU192652.1 
    EU192653.1 J05480.1 L14778.1 

    17 DOTS entries:

    DT.99946684  DT.91684424  DT.91758409  DT.100816745  DT.121218547  DT.100018302  DT.95301719  DT.95261425 
    DT.121218599  DT.95261337  DT.101982149  DT.121218591  DT.121630896  DT.121218560  DT.206962  DT.95198610 
    DT.99995242 

    24/216 AceView cDNA sequences (see all 216):

    AA121266 BQ019059 AA195063 BQ773845 BM693389 AI300489 BC025714 BU754329 
    BM974160 AI093423 AI342625 AA693992 BU618816 BQ006346 CA427493 AI160417 
    CD014046 CA446739 AA449285 CD014045 CA427394 AI804248 AA253067 AW627967 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                    
    SP2:                                                                          -         
    SP3:        -                                                                 -         
    SP4:                                                  -                       -         


    ECgene alternative splicing isoforms for PPP3CA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP3CA expression in normal human tissues (normalized intensities)      PPP3CA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTTATTT
    PPP3CA Expression
    About this image


    PPP3CA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Pons
             Subthalamic Nucleus   
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Blood (Cardiovascular System)
             T-Cytotoxic Cells Thymus
     
     Larynx (Respiratory System)

    See PPP3CA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP3CA

    SOURCE GeneReport for Unigene cluster: Hs.435512
        SABiosciences Expression via Pathway-Focused PCR Arrays including PPP3CA (see all 7): 
              Cytoskeleton Regulators in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Protein Phosphatases in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3CA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPP3CA gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp3ca1 , 5 protein phosphatase 3, catalytic subunit, alpha isoform1, 5 92.71(n)1
    99.62(a)1
      3 (63.34 cM)5
    190551  NM_008913.41  NP_032939.11 
     1366701245 
    chicken
    (Gallus gallus)
    Aves PPP3CA1 protein phosphatase 3 (formerly 2B), catalytic subunit, more 88.67(n)
    97.84(a)
      395113  XM_420664.3  XP_420664.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPP3CA6
    protein phosphatase 3, catalytic subunit, alpha is...
    98(a)
    1 ↔ 1
    GL343323.1(542801-755884)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppp3ca-prov2 protein phosphatase 3 (formerly 2B), catalytic subunit, more 84.36(n)    AB037146.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.74272 Transcribed sequence with strong similarity to protein more 75.99(n)    57075004 
    fruit fly
    (Drosophila melanogaster)
    Insecta CanA-14F3
    Pp2B-14D1
    protein amino acid dephosphorylation
    protein serine/threonine more3
    Protein phosphatase 2B at 14D1
    80(a)
    (best of 4)3
    67.37(n)1
    83.05(a)1
      326241  NM_078649.31  NP_523373.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F42G8.83
    tax-61
    ser/thr-protein phosphatase3
    Protein TAX-61
    34(a)
    (best of 3)3
    67.79(n)1
    77.8(a)1
      IV(8119386-8122425)3
    1779431  NM_001026122.21  NP_001021293.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMP2(YML057W)4
    CNA11
    Calcineurin A; one isoform (the other is CNA1) of the more4
    Cna1p1
    58.1(n)1
    56.7(a)1
      13(160180-161994)4
    8511531  NP_013537.11  8549464 
     NP_013655.14 


    ENSEMBL Gene Tree for PPP3CA (if available)
    TreeFam Gene Tree for PPP3CA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP3CA gene
    PPP3CC2  PPP3CB2  
    11 SIMAP similar genes for PPP3CA using alignment to 7 protein entries:     PP2BA_HUMAN (see all proteins):
    PPP3CC    PPP3CB    PPP1CB    PPP1CA    PPP2CB    PPP6C
    PPP1CC    PPP2CA    PPP5C    PPEF1    PPP4C

    PPP3CA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5920 SNPs in PPP3CA are shown (see all 5920)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58606581,2
    C--97814197(+) ttttt-/T/TT  
            
    gtgat
    3 -- int11NA 2
    rs58606561,2
    C--101829866(+) AAAGA-/AA/A  
      GA
    /GGA
    GAAAA
    9 -- int1 cds10--------
    rs1164168661,2
    C,F--101944186(+) GGATAT/CTTTAG 3 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1806980971,2
    --101944295(+) GTCACC/TGTGGG 3 -- ds50010--------
    rs792705001,2
    C,F--101944405(+) TTCTAT/CAGTTT 3 -- ds50011Minor allele frequency- C:0.05WA 118
    rs78401,2
    C,F,O,A--101944669(-) AAAAAA/TTTCAT 3 -- ut317Minor allele frequency- T:0.14MN NA WA 430
    rs1418005401,2
    C--101944780(+) AAATAC/TTTTCC 3 -- ut310--------
    rs68269121,2
    C,F,H--101945139(+) TTGCTT/GTAGCA 3 -- ut31 ese37Minor allele frequency- G:0.14NS EA NA WA 650
    rs1508034521,2
    --101945302(+) AGACAC/TAAATC 3 -- ut310--------
    rs1380273661,2
    C--101945400(+) ATGTGA/TGGTGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP3CA (101944566 - 102194566 bp, first 250kb of PPP3CA)

    Structural Variations
         Database of Genomic Variants (DGV) 10/30 variations for PPP3CA (see all 30):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728048CNV Deletion23290073
    esv2674848CNV Deletion23128226
    esv2602939CNV Deletion19546169
    esv2728052CNV Deletion23290073
    esv2203085CNV Deletion18987734
    esv2728049CNV Deletion23290073
    esv2728053CNV Deletion23290073
    esv2663140CNV Deletion23128226
    esv2677866CNV Deletion23128226
    esv2728050CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114105    OMIM disorders: --

    20/25 diseases for PPP3CA (see all 25):    About MalaCards
    osteomyelitis    down syndrome critical region    dental caries    congestive heart failure
    keratoconus    down syndrome    amyotrophic lateral sclerosis    lateral sclerosis
    hypothyroidism    osteoarthritis    huntington's disease    myopathy
    cystic fibrosis    pneumonia    parkinson's disease    schizophrenia
    hypertension    alzheimer's disease    tuberculosis    melanoma


    PPP3CA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for PPP3CA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteomyelitis 50.3 1 11792597 (1)
    hypertrophy 17.4 3 15723976 (1), 12639710 (1), 16389460 (1)

    Genetic Association Database (GAD): PPP3CA
    Human Genome Epidemiology (HuGE) Navigator: PPP3CA (15 documents)

    Export disorders for PPP3CA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP3CA gene, integrated from 9 sources (see all 164):
    (articles sorted by number of sources associating them with PPP3CA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine mapping of calcineurin (PPP3CA) gene reveals nov el alternative splicing patterns, association of 5'UTR trinucleotide repeat wit h addiction vulnerability, and differential isoform expression in Alzheimer's d isease. (PubMed id 20590401)1, 2, 4 Chiocco M.J....Liu Q.R. (2010)
    2. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal trans plantation in developed countries. (PubMed id 21979947)1, 4 Li X....Rabinowitz Y.S. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (2008)
    6. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    7. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2 Wang Y.... Mizuno K. (2005)
    8. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. (PubMed id 11842093)1, 2 Frey N. and Olson E.N. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5530 HGNC: 9314 AceView: PPP3CA Ensembl:ENSG00000138814 euGenes: HUgn5530
    ECgene: PPP3CA Kegg: 5530 H-InvDB: PPP3CA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP3CA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP3CA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Calcineurin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP3CA gene:
    Search GeneIP for patents involving PPP3CA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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