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PPP3CA Gene

protein-coding   GIFtS: 73
GCID: GC04M101944

Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme

(Previous names: protein phosphatase 3 (formerly 2B), catalytic subunit,...)
(Previous symbols: CALN, CALNA)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme1 2     Alpha Isoform1
CALNA1 2 3 5     Catalytic Subunit1
CALN1 2     Protein Phosphatase 2B1
Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform1 2     Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform
(Calcineurin A Alpha)1
Calcineurin A Alpha1 2     CALNA12
Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform2 3     CCN12
CAM-PRP Catalytic Subunit2 3     Protein Phosphatase 2B, Catalytic Subunit, Alpha Isoform2
EC 3.1.3.163 8     Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Alpha Isoform2
CNA12 5     CNA3
PPP2B2 5     

External Ids:    HGNC: 93141   Entrez Gene: 55302   Ensembl: ENSG000001388147   OMIM: 1141055   UniProtKB: Q082093   

Export aliases for PPP3CA gene to outside databases

Previous GC identifers: GC04M102343 GC04M102402 GC04M102301 GC04M102163 GC04M097682


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPP3CA Gene:
PPP3CA (protein phosphatase 3, catalytic subunit, alpha isozyme) is a protein-coding gene. Diseases associated with PPP3CA include osteomyelitis, and dental caries. GO annotations related to this gene include enzyme binding and calcium ion binding. An important paralog of this gene is PPP3CC.

UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209
Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT
motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1
and SSH1

Gene Wiki entry for PPP3CA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP3CA gene promoter:
         AML1a   GATA-3   MyoD   Meis-1b   HNF-1A   Evi-1   HNF-1   Meis-1a   ZIC2/Zic2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP3CA promoter sequence
   Search Chromatin IP Primers for PPP3CA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP3CA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

PPP3CA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP3CA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M101944:  view genomic region     (about GC identifiers)

Start:
101,944,566 bp from pter      End:
102,269,435 bp from pter
Size:
324,870 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform  
Size: 521 amino acids; 58688 Da
Cofactor: Binds 1 Fe(3+) ion per subunit
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts
with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is the catalytic
subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts
with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts
with CMYA5; this interaction represses calcineurin activity in muscle (By similarity)
Selected PDB 3D structures from and Proteopedia for PPP3CA (see all 10):
1AUI (3D)        1M63 (3D)        1MF8 (3D)        2JOG (3D)        2JZI (3D)        2P6B (3D)    
Secondary accessions: A8K3B7 A8W6Z7 A8W6Z8 B5BUA2 Q8TAW9
Alternative splicing: 4 isoforms:  Q08209-1   Q08209-2   Q08209-3   Q08209-4   

Explore the universe of human proteins at neXtProt for PPP3CA: NX_Q08209

Explore proteomics data for PPP3CA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys142, Lys323
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP3CA (Q08209) (see all 26)
     KLFEVGG  PHPYWLP  CGDIHGQ  DRFKEPP 


    See PPP3CA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000935.1  NP_001124163.1  NP_001124164.1  

    ENSEMBL proteins: 
     ENSP00000422781   ENSP00000378323   ENSP00000320580   ENSP00000378322   ENSP00000422990  
     ENSP00000426565   ENSP00000431619   ENSP00000434599   ENSP00000429350  
    Reactome Protein details: Q08209

    PPP3CA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PPP3CA (Calcineurin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PPP3CA
    GenScript Custom Purified and Recombinant Proteins Services for PPP3CA
    Novus Biologicals PPP3CA Proteins
    Sino Biological Recombinant Protein for PPP3CA
    Sino Biological Cell Lysate for PPP3CA
    ProSpec Recombinant Protein for PPP3CA
    Browse Proteins at Cloud-Clone Corp.

    PPP3CA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP3CA
    R&D Systems Antibodies for PPP3CA (Calcineurin A)
    OriGene Antibodies for PPP3CA
    OriGene Custom Antibody Services for PPP3CA
    Novus Biologicals PPP3CA Antibodies
    Abcam antibodies for PPP3CA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPP3CA
    LSBio Antibodies in human, mouse, rat for PPP3CA

    PPP3CA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP3CA
    R&D Systems Enzyme Activity Assays & Reagents for PPP3CA (Calcineurin)
    GenScript Custom Assay Services for PPP3CA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry Q08209

    ProtoNet protein and cluster: Q08209

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209
    Similarity: Belongs to the PPP phosphatase family. PP-2B subfamily


    PPP3CA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP2BA_HUMAN, Q08209
    Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT
    motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1
    and SSH1
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for PPP3CA:
    calcineurin A alpha isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,58-59kDa,also
    abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity NAS8392375
    GO:0004723calcium-dependent protein serine/threonine phosphatase activity ----
    GO:0005509calcium ion binding NAS8392375
    GO:0005515protein binding IPI11114196
         
    PPP3CA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPP3CA:
     Decreased focal adhesion (FA)   Synthetic lethal with imatinib  Synthetic lethal with paclitax 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp3ca):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  renal/urinary system 

    PPP3CA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp3catm1Jse for PPP3CA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP3CA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP3CA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP3CA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP3CA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP3CA:
    hsa-mir-145-5p (MIRT000677), hsa-mir-30a-5p (MIRT005198)

    Block miRNA regulation of human, mouse, rat PPP3CA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP3CA (see all 104):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-632 hsa-miR-30d hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP3CA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP3CA
    Predesigned siRNA for gene silencing in human, mouse, rat PPP3CA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP3CA

    Clone
    Products:
         
    OriGene clones in human, mouse for PPP3CA (see all 18)
    OriGene ORF clones in mouse, rat for PPP3CA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPP3CA (NM_000944)
    Sino Biological Human cDNA Clone for PPP3CA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP3CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3CA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP3CA
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPP3CA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3CA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP2BA_HUMAN, Q08209: Cell membrane (By similarity). Cell membrane, sarcolemma (By similarity). Nucleus (By
    similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton2
    mitochondrion2
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    PPP3CA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP3CA About   (see all 57)                                                                                              See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    4Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Amyotrophic lateral sclerosis (ALS)0.63
    5Ca-dependent events
    Opioid Signalling0.54
    Signal transduction Calcium signaling0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for PPP3CA
        Wnt Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP3CA (see all 33)
        14-3-3 Induced Apoptosis
    Intracellular Calcium Signaling
    PI3K Signaling in B-Lymphocyte
    IL-2 Pathway
    ITK and TCR Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PPP3CA (see all 20)
        Signal transduction cAMP signaling
    Immune response CD28 signaling
    Immune response CD16 signaling in NK cells
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for PPP3CA (see all 11)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    G Protein Signaling Pathways
    Spinal Cord Injury
    Amyotrophic lateral sclerosis (ALS)


    3 Reactome Pathways for PPP3CA
        DARPP-32 events
    Ca2+ pathway
    FCERI mediated Ca+2 mobilization

    1 PharmGKB Pathway for PPP3CA
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PPP3CA) (see all 20):
        MAPK signaling pathway
    Calcium signaling pathway
    Oocyte meiosis
    Apoptosis
    Wnt signaling pathway


    PPP3CA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP3CA (see all 7): 
              Cytoskeleton Regulators in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PPP3CA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP3CA (Q082091, 2, 3 ENSP000003783234) via UniProtKB, MINT, STRING, and/or I2D (see all 301)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-352922,EBI-401755 MINT-8256591 I2D: score=5 STRING: ENSP00000339007
    C16orf74Q96GX82, 3, ENSP000002842454MINT-67845 I2D: score=4 STRING: ENSP00000284245
    USP14P545781, 2, 3, ENSP000002616014EBI-352922,EBI-1048016 MINT-7295968 MINT-7296006 MINT-7295951 MINT-7295936 I2D: score=1 STRING: ENSP00000261601
    ENSG00000206289P287023I2D: score=1 
    ENSG00000206353Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006470protein dephosphorylation NAS8392375
    GO:0006606protein import into nucleus IEA--
    GO:0006816calcium ion transport IEA--

    PPP3CA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP3CA (PP2BA)

    3 HMDB Compounds for PPP3CA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PPP3CA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --target--10592235

    5 Novoseek inferred chemical compound relationships for PPP3CA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enterotoxin 44.9 1 15741366 (1)
    tacrolimus 44.8 4 18172213 (1), 8880916 (1)
    cyclosporin a 29.1 2 12639710 (1)
    calcium 19.7 3 17339875 (1), 18187190 (1), 12764228 (1)
    fibrinogen 7.72 2 17133904 (1), 10463169 (1)



    PPP3CA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for PPP3CA gene (3 alternative transcripts): 
    NM_000944.4  NM_001130691.1  NM_001130692.1  

    Unigene Cluster for PPP3CA:

    Protein phosphatase 3, catalytic subunit, alpha isozyme
    Hs.435512  [show with all ESTs]
    Unigene Representative Sequence: NM_000944
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512215(uc010ilk.2) ENST00000394854(uc011cen.1 uc003hvu.2 uc010ilj.2 uc003hvt.2 uc003hvs.2)
    ENST00000323055 ENST00000394853 ENST00000507176 ENST00000492351 ENST00000510292
    ENST00000529324 ENST00000525819 ENST00000523694

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPP3CA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP3CA (see all 104):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-632 hsa-miR-30d hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPP3CA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PPP3CA
    Predesigned siRNA for gene silencing in human, mouse, rat PPP3CA
    Clone
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    OriGene clones in human, mouse for PPP3CA (see all 18)
    OriGene ORF clones in mouse, rat for PPP3CA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPP3CA (NM_000944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP3CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3CA
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PPP3CA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP3CA
      QuantiTect SYBR Green Assays in human, mouse, rat PPP3CA
      QuantiFast Probe-based Assays in human, mouse, rat PPP3CA

    Additional mRNA sequence: 

    AB451338.1 AB451487.1 AK290532.1 AL353950.1 AY904364.1 BC025714.1 BC098424.1 EU192652.1 
    EU192653.1 J05480.1 L14778.1 

    17 DOTS entries:

    DT.99946684  DT.91684424  DT.91758409  DT.100816745  DT.121218547  DT.100018302  DT.95301719  DT.95261425 
    DT.121218599  DT.95261337  DT.101982149  DT.121218591  DT.121630896  DT.121218560  DT.206962  DT.95198610 
    DT.99995242 

    Selected AceView cDNA sequences (see all 216):

    AA121266 BQ019059 AA195063 BQ773845 BM693389 AI300489 BC025714 BU754329 
    BM974160 AA253067 AW627967 H96258 BQ027445 CD014047 AA683143 AW207635 
    AW082224 BQ723418 AA887538 BM974203 AA449230 BQ448360 BF173986 CA432423 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                    
    SP2:                                                                          -         
    SP3:        -                                                                 -         
    SP4:                                                  -                       -         


    ECgene alternative splicing isoforms for PPP3CA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP3CA expression in normal human tissues (normalized intensities)      PPP3CA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTTATTT
    PPP3CA Expression
    About this image


    PPP3CA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood (Cardiovascular System)
             T-Cytotoxic Cells Thymus
     
     Larynx (Respiratory System)
    PPP3CA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP3CA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435512
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP3CA (see all 7): 
              Cytoskeleton Regulators in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Protein Phosphatases in human mouse rat

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    OriGene qSTAR qPCR primer pairs in human, mouse for PPP3CA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3CA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPP3CA gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp3ca1 , 5 protein phosphatase 3, catalytic subunit, alpha isoform1, 5 92.71(n)1
    99.62(a)1
      3 (63.34 cM)5
    190551  NM_008913.41  NP_032939.11 
     1366701245 
    chicken
    (Gallus gallus)
    Aves PPP3CA1 protein phosphatase 3 (formerly 2B), catalytic subunit, more 89.22(n)
    98.61(a)
      395113  XM_420664.4  XP_420664.4 
    lizard
    (Anolis carolinensis)
    Reptilia PPP3CA6
    protein phosphatase 3, catalytic subunit, alpha is...
    98(a)
    1 ↔ 1
    GL343323.1(542801-755884)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppp3ca-prov2 protein phosphatase 3 (formerly 2B), catalytic subunit, more 84.36(n)    AB037146.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.74272 Transcribed sequence with strong similarity to protein more 75.99(n)    57075004 
    fruit fly
    (Drosophila melanogaster)
    Insecta CanA-14F3
    Pp2B-14D1
    protein amino acid dephosphorylation
    protein serine/threonine more3
    Protein phosphatase 2B at 14D1
    80(a)
    (best of 4)3
    67.37(n)1
    83.05(a)1
      326241  NM_078649.31  NP_523373.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F42G8.83
    tax-61
    ser/thr-protein phosphatase3
    tax-61
    34(a)
    (best of 3)3
    67.71(n)1
    76.62(a)1
      IV(8119386-8122425)3
    1779431  NM_001083189.41  NP_001076658.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMP2(YML057W)4
    CNA11
    Calcineurin A; one isoform (the other is CNA1) of the more4
    CNA11
    58.1(n)1
    56.7(a)1
      13(160180-161994)4
    8511531  NP_013537.11  8549464 
     NP_013655.14 


    ENSEMBL Gene Tree for PPP3CA (if available)
    TreeFam Gene Tree for PPP3CA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP3CA gene
    PPP3CC2  PPP3CB2  
    10 SIMAP similar genes for PPP3CA using alignment to 6 protein entries:     PP2BA_HUMAN (see all proteins):
    PPP3CC    PPP3CB    PPP1CB    PPP1CC    PPP1CA    PPP2CB
    PPP6C    PPP2CA    PPP5C    PPP4C

    PPP3CA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP3CA (see all 5920)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58606581,2
    C--97814197(+) ttttt-/T/TT  
            
    gtgat
    3 -- int11NA 2
    rs58606561,2
    C--101829866(+) AAAGA-/AA/A  
      GA
    /GGA
    GAAAA
    9 -- int1 cds10--------
    rs1164168661,2
    C,F--101944186(+) GGATAT/CTTTAG 3 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1806980971,2
    --101944295(+) GTCACC/TGTGGG 3 -- ds50010--------
    rs792705001,2
    C,F--101944405(+) TTCTAT/CAGTTT 3 -- ds50011Minor allele frequency- C:0.05WA 118
    rs78401,2
    C,F,O,A--101944669(-) AAAAAA/TTTCAT 3 -- ut317Minor allele frequency- T:0.14MN NA WA 430
    rs1418005401,2
    C--101944780(+) AAATAC/TTTTCC 3 -- ut310--------
    rs68269121,2
    C,F,H--101945139(+) TTGCTT/GTAGCA 3 -- ut31 ese37Minor allele frequency- G:0.14NS EA NA WA 650
    rs1508034521,2
    --101945302(+) AGACAC/TAAATC 3 -- ut310--------
    rs1380273661,2
    C--101945400(+) ATGTGA/TGGTGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP3CA (101944566 - 102194566 bp, first 250kb of PPP3CA)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPP3CA (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728048CNV Deletion23290073
    esv2674848CNV Deletion23128226
    esv2602939CNV Deletion19546169
    esv2728052CNV Deletion23290073
    esv2203085CNV Deletion18987734
    esv2728049CNV Deletion23290073
    esv2728053CNV Deletion23290073
    esv2663140CNV Deletion23128226
    esv2677866CNV Deletion23128226
    esv2728050CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP3CA
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP3CA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114105    OMIM disorders: --

    Selected diseases for PPP3CA (see all 32):    About MalaCards
    osteomyelitis    dental caries    keratoconus    congestive heart failure
    down syndrome    hypothyroidism    spinal cord injury    amyotrophic lateral sclerosis
    lateral sclerosis    sepsis    osteoarthritis    myopathy
    huntington's disease    cystic fibrosis    hepatitis c virus    parkinson's disease
    pneumonia    hepatitis c    schizophrenia    hypertension


    PPP3CA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for PPP3CA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteomyelitis 50.3 1 11792597 (1)
    hypertrophy 17.4 3 15723976 (1), 12639710 (1), 16389460 (1)

    Genetic Association Database (GAD): PPP3CA
    Human Genome Epidemiology (HuGE) Navigator: PPP3CA (15 documents)

    Export disorders for PPP3CA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP3CA gene, integrated from 10 sources (see all 169):
    (articles sorted by number of sources associating them with PPP3CA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. (PubMed id 20590401)1, 2, 4 Chiocco M.J.... Liu Q.R. (Subst. Use Misuse 2010)
    2. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. (PubMed id 21979947)1, 4 Li X....Rabinowitz Y.S. (Hum. Mol. Genet. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
    6. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    7. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2 Wang Y.... Mizuno K. (J. Biol. Chem. 2005)
    8. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (Cell 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. (PubMed id 11842093)1, 2 Frey N. and Olson E.N. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5530 HGNC: 9314 AceView: PPP3CA Ensembl:ENSG00000138814 euGenes: HUgn5530
    ECgene: PPP3CA Kegg: 5530 H-InvDB: PPP3CA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP3CA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP3CA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Calcineurin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP3CA gene:
    Search GeneIP for patents involving PPP3CA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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