PPP3CA Gene
protein-coding GIFtS: 71
GCID: GC04M101944
|
|
protein phosphatase 3, catalytic subunit, alpha isozyme(Previous names: protein phosphatase 3 (formerly 2B), catalytic subunit,...)
(Previous symbols: CALN, CALNA)
| |
Aliases
for PPP3CA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme1 2 | | EC 3.1.3.163 8 | | CALNA1 2 3 5 | | Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform(Calcineurin A Alpha)1 | | CNA11 2 5 | | CALNA12 | | PPP2B1 2 5 | | CCN12 | | CALN1 2 | | Calcineurin A Alpha2 | | Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform1 2 | | Protein Phosphatase 2B, Catalytic Subunit, Alpha Isoform2 | | Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform2 3 | | Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Alpha Isoform2 | | CAM-PRP Catalytic Subunit2 3 | | CNA3 |
Export aliases for PPP3CA gene to outside databasesPrevious GC identifers: GC04M102343 GC04M102402 GC04M102301 GC04M102163 GC04M097682 |
Summaries
for PPP3CA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulinactivation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1
Gene Wiki entry for PPP3CA
|
Genomic Views
for PPP3CA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPP3CA gene promoter:
AML1a GATA-3 MyoD Meis-1b HNF-1A Evi-1 HNF-1 Meis-1a ZIC2/Zic2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPP3CA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP3CA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24PPP3CA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M101944: view genomic region
(about GC identifiers)
Start:
|
101,944,566 bp from pter |
End:
|
102,269,435 bp from pter |
Size:
|
324,870 bases |
Orientation:
|
minus strand |
|
Proteins
for PPP3CA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209 (See
protein sequence)Recommended Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Size: 521 amino acids; 58688 Da
Cofactor: Binds 1 Fe(3+) ion per subunit
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is thecatalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3.Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria.Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity)
Subcellular location: Nucleus (By similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart andskeletal muscle (By similarity)
6/9 PDB 3D structures from  and Proteopedia  for PPP3CA (see all 9):1AUI (3D)
1M63 (3D)
1MF8 (3D)
2JOG (3D)
2JZI (3D)
2P6B (3D)
Secondary accessions: A8K3B7 A8W6Z7 B5BUA2 Q8TAW9Alternative splicing: 3 isoforms: Q08209-1 Q08209-2 Q08209-3 Explore the universe of human proteins at neXtProt for PPP3CA: NX_Q08209
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08209
4/26 DME Specific Peptides for PPP3CA (Q08209) (see all 26)
PPP3CA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000935.1 NP_001124163.1 NP_001124164.1
ENSEMBL proteins: ENSP00000422781 ENSP00000378323 ENSP00000320580 ENSP00000378322 ENSP00000422990 ENSP00000426565 ENSP00000431619 ENSP00000434599 ENSP00000429350 Reactome Protein details: Q08209
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
PPP3CA for ontologies About GeneDecksing
PPP3CA Antibody Products:
Assay Products for PPP3CA: |
Protein
Domains /
Families
for PPP3CA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPP3CA for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08209ProtoNet protein and cluster: Q08209 1 Blocks protein family: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209Similarity: Belongs to the PPP phosphatase family. PP-2B subfamily |
Function
for PPP3CA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PP2BA_HUMAN, Q08209Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulinactivation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate Genatlas biochemistry entry for PPP3CA:calcineurin A alpha isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,58-59kDa,alsoabundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation
Enzyme Number (IUBMB): EC 3.1.3.161 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP3CA (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP3CA (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PPP3CA (NM_000944) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP3CA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3CA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3CA |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
PPP3CA for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for PPP3CA:
Animal Models:
Mouse knock-out Ppp3catm1Jse for PPP3CA
9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ppp3ca):
PPP3CA for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPP3CA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/58 super-pathways (see all 58) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_IL-2 activation and signaling pathway | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | PKC-Theta Pathway | | | 4 | B cell receptor signaling pathway | | | 5 | Opioid Signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/18 EMD Millipore Pathways for PPP3CA (see all 18)
1  R&D Systems Pathway for PPP3CA
5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP3CA (see all 33)
5/20  GeneGo (Thomson Reuters) Pathways for PPP3CA (see all 20)
5/8  BioSystems Pathways for PPP3CA (see all 8)
5 
Reactome Pathways for PPP3CA
1  PharmGKB Pathway for PPP3CA
5/16 
Kegg Pathways (Kegg details for PPP3CA) (see all 16):
PPP3CA for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP3CA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/175 Interacting proteins for PPP3CA (Q082091, 2, 3 ENSP000003783234) via UniProtKB, MINT, STRING, and/or I2D (see all 175)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
PPP3CA for ontologies About GeneDecksing
|
Drugs & Compounds
for PPP3CA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PPP3CA for compounds About GeneDecksing
 Browse Tocris compounds for PPP3CA
3 HMDB Compounds for PPP3CA About this table
1 DrugBank Compound for PPP3CA About this table
5 Novoseek chemical compound relationships for PPP3CA gene About this table
Search CenterWatch for drugs/clinical trials and news about PPP3CA / PP2BA
|
Transcripts
for PPP3CA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPP3CA gene (3 alternative transcripts): NM_000944.4 NM_001130691.1 NM_001130692.1 Unigene Cluster for PPP3CA: Protein phosphatase 3, catalytic subunit, alpha isozyme Hs.435512 [show with all ESTs]Unigene Representative Sequence: NM_00094410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000512215(uc010ilk.2) ENST00000394854(uc011cen.1 uc003hvu.2 uc010ilj.2 uc003hvt.2 uc003hvs.2)
ENST00000323055 ENST00000394853 ENST00000507176 ENST00000492351 ENST00000510292
ENST00000529324 ENST00000525819 ENST00000523694
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP3CA (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP3CA (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PPP3CA (NM_000944) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP3CA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3CA |
Additional cDNA sequence: AB451338.1 AB451487.1 AK290532.1 AL353950.1 AY904364.1 BC025714.1 BC098424.1 EU192652.1 EU192653.1 J05480.1 L14778.1 17 DOTS entries: DT.99946684 DT.91684424 DT.91758409 DT.100816745 DT.121218547 DT.100018302 DT.95301719 DT.95261425 DT.121218599 DT.95261337 DT.101982149 DT.121218591 DT.121630896 DT.121218560 DT.206962 DT.95198610 DT.99995242 24/216 AceView cDNA sequences (see all 216): BM693389 BQ019059 AI300489 BQ773845 AA121266 AA195063 BF173986 AA449230 BQ448360 AI342625 CA432423 AI093423 AA693992 CA427493 CA446739 BU618816 BQ006346 CD014046 AI160417 AA449285 CD014045 CA427394 AI804248 BU754329
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CA About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | |
ECgene alternative splicing isoforms for PPP3CA
|
Expression
for PPP3CA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPP3CA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTTATTT
About this image
See PPP3CA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP3CA
SOURCE GeneReport for Unigene cluster: Hs.435512
SABiosciences Expression via Pathway-Focused PCR Arrays including PPP3CA (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP3CA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP3CA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP3CA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP3CA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3CA |
Orthologs
for PPP3CA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPP3CA gene from 9/36 species (see all 36) About this table
ENSEMBL Gene Tree for PPP3CA (if available)
TreeFam Gene Tree for PPP3CA (if available) |
Paralogs
for PPP3CA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPP3CA gene
- PPP3CC2 PPP3CB2
11 SIMAP similar genes for PPP3CA using alignment to 7 protein entries: PP2BA_HUMAN (see all proteins):PPP3CC PPP3CB PPP1CB PPP1CA PPP2CB PPP6C
PPP1CC PPP2CA PPP5C PPEF1 PPP4C
PPP3CA for paralogs About GeneDecksing
|
Genomic Variants
for PPP3CA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for PPP3CA
4 CNVs: 39387 98821 63906 63908
5 Indels: 59158 92268 98820 92269 80413 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP3CA |
|
Disorders
/ Diseases
for PPP3CA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPP3CA for disorders About GeneDecksing
OMIM gene information: 114105
OMIM disorders: --
20/28  diseases for PPP3CA (see all 28): About MalaCardsdown syndrome critical region amyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis dental caries
congestive heart failure lateral sclerosis atrial fibrillation osteomyelitis
down syndrome cystic fibrosis huntington's disease hypothyroidism
parkinson's disease fibrosis alzheimer's disease neurodegeneration
osteoarthritis lung cancer breast cancer pneumonia
2 Novoseek disease relationships for PPP3CA gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| osteomyelitis |
50.3 |
1 |
11792597 (1) |
| hypertrophy |
17.4 |
3 |
15723976 (1), 12639710 (1), 16389460 (1) |
Human Genome Epidemiology (HuGE) Navigator: PPP3CA (15 documents)
Export disorders for PPP3CA gene to outside databases
|
Publications
for PPP3CA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPP3CA gene, integrated from 9 sources (see all 156):
(articles sorted by number of sources associating them with PPP3CA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fine mapping of calcineurin (PPP3CA) gene reveals nov el alternative splicing patterns, association of 5'UTR trinucleotide repeat wit h addiction vulnerability, and differential isoform expression in Alzheimer's d isease. (PubMed id 20590401)1, 2 Chiocco M.J....Liu Q.R. (2010)
- Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2 Wang Y.... Mizuno K. (2005)
- The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. (PubMed id 11842093)1, 2 Frey N. and Olson E.N. (2002)
- Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. (PubMed id 11114196)1, 2 Frey N.... Olson E.N. (2000)
- Crystal structures of human calcineurin and the human FKBP12-FK506- calcineurin complex. (PubMed id 8524402)1, 2 Kissinger C.R.... Villafranca J.E. (1995)
- Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). (PubMed id 8392375)1, 2 Muramatsu T. and Kincaid R.L. (1993)
- Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. (PubMed id 1659808)1, 3 Giri P.R....Kincaid R.L. (1991)
- Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. (PubMed id 2848250)1, 3 Kincaid R.L....Martin B.M. (1988)
|
External Searches for PPP3CA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPP3CA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPP3CA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPP3CA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PPP3CA gene:
Search GeneIP for patents involving PPP3CA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPP3CA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for PPP3CA | | OriGene shRNA RFP for PPP3CA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP3CA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP3CA | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPP3CA | | OriGene 3'-UTR Clone for PPP3CA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP3CA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP3CA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPP3CA | | OriGene Custom Protein Services for PPP3CA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP3CA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP3CA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP3CA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP3CA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP3CA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP3CA |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PPP3CA |
| |  |  |  |  | | | | | | Recombinant Protein for PPP3CA |
|
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP3CA |
|  |  |  | | | | ThermoFisher Antibodies for PPP3CA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP3CA |
|
|
|
|
