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Aliases for PPP3CA Gene

Aliases for PPP3CA Gene

  • Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme 2 3
  • CALNA 3 4 6
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform 3 4
  • CAM-PRP Catalytic Subunit 3 4
  • Calcineurin A Alpha 2 3
  • EC 4 63
  • PPP2B 3 6
  • CNA1 3 6
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform (Calcineurin A Alpha) 2
  • Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Alpha Isoform 3
  • Protein Phosphatase 2B, Catalytic Subunit, Alpha Isoform 3
  • Protein Phosphatase 2B 2
  • Catalytic Subunit 2
  • Alpha Isoform 2
  • CALNA1 3
  • CCN1 3
  • CALN 3
  • CNA 4

External Ids for PPP3CA Gene

Previous Symbols for PPP3CA Gene

  • CALN

Summaries for PPP3CA Gene

GeneCards Summary for PPP3CA Gene

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme) is a Protein Coding gene. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is PPP3CB.

UniProtKB/Swiss-Prot for PPP3CA Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

Gene Wiki entry for PPP3CA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CA Gene

Genomics for PPP3CA Gene

Genomic Location for PPP3CA Gene

101,023,409 bp from pter
101,348,278 bp from pter
324,870 bases
Minus strand

Genomic View for PPP3CA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP3CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CA Gene

Regulatory Elements for PPP3CA Gene

Proteins for PPP3CA Gene

  • Protein details for PPP3CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    Protein Accession:
    Secondary Accessions:
    • A1A441
    • A8K3B7
    • A8W6Z7
    • A8W6Z8
    • B5BUA2
    • Q8TAW9

    Protein attributes for PPP3CA Gene

    521 amino acids
    Molecular mass:
    58688 Da
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Note=Binds 1 Fe(3+) ion per subunit.;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity).

    Three dimensional structures from OCA and Proteopedia for PPP3CA Gene

    Alternative splice isoforms for PPP3CA Gene


neXtProt entry for PPP3CA Gene

Proteomics data for PPP3CA Gene at MOPED

Post-translational modifications for PPP3CA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32, Lys142, and Lys323

Other Protein References for PPP3CA Gene

Domains for PPP3CA Gene

Gene Families for PPP3CA Gene

  • PPP :Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PPP phosphatase family. PP-2B subfamily.:
    • Q08209
genes like me logo Genes that share domains with PPP3CA: view

Function for PPP3CA Gene

Molecular function for PPP3CA Gene

GENATLAS Biochemistry: calcineurin A alpha isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,58-59kDa,also abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

Enzyme Numbers (IUBMB) for PPP3CA Gene

Gene Ontology (GO) - Molecular Function for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity NAS 8392375
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity --
GO:0005509 calcium ion binding NAS 8392375
GO:0005515 protein binding IPI 11114196
genes like me logo Genes that share ontologies with PPP3CA: view
genes like me logo Genes that share phenotypes with PPP3CA: view

Animal Models for PPP3CA Gene

MGI Knock Outs for PPP3CA:

miRNA for PPP3CA Gene

miRTarBase miRNAs that target PPP3CA

No data available for Transcription Factor Targeting and HOMER Transcription for PPP3CA Gene

Localization for PPP3CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP3CA Gene

Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PPP3CA Gene COMPARTMENTS Subcellular localization image for PPP3CA gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP3CA: view

Pathways for PPP3CA Gene

genes like me logo Genes that share pathways with PPP3CA: view

Gene Ontology (GO) - Biological Process for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001975 response to amphetamine IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006470 protein dephosphorylation NAS 8392375
GO:0006606 protein import into nucleus IEA --
genes like me logo Genes that share ontologies with PPP3CA: view

Compounds for PPP3CA Gene

(3) HMDB Compounds for PPP3CA Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • NFB Orthophosphate
  • Dihydrogen oxide

(1) Drugbank Compounds for PPP3CA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs

(5) Novoseek inferred chemical compound relationships for PPP3CA Gene

Compound -log(P) Hits PubMed IDs
enterotoxin 44.9 1
tacrolimus 44.8 2
cyclosporin a 29.1 1
calcium 19.7 3
fibrinogen 7.72 2
genes like me logo Genes that share compounds with PPP3CA: view

Transcripts for PPP3CA Gene

Unigene Clusters for PPP3CA Gene

Protein phosphatase 3, catalytic subunit, alpha isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP2: -
SP3: - -
SP4: - -

Relevant External Links for PPP3CA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP3CA Gene

mRNA expression in normal human tissues for PPP3CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP3CA Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (5.8), Brain - Caudate (basal ganglia) (5.6), Brain - Nucleus accumbens (basal ganglia) (5.3), and Brain - Frontal Cortex (BA9) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3CA Gene

SOURCE GeneReport for Unigene cluster for PPP3CA Gene Hs.435512

genes like me logo Genes that share expressions with PPP3CA: view

No data available for mRNA Expression by UniProt/SwissProt for PPP3CA Gene

Orthologs for PPP3CA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP3CA 35
  • 99.3 (n)
  • 99.42 (a)
  • 100 (a)
(Bos Taurus)
Mammalia PPP3CA 35
  • 95.65 (n)
  • 99.62 (a)
  • 100 (a)
(Canis familiaris)
Mammalia PPP3CA 35
  • 96.42 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Ppp3ca 35
  • 92.71 (n)
  • 99.62 (a)
Ppp3ca 16
Ppp3ca 36
  • 100 (a)
(Monodelphis domestica)
Mammalia PPP3CA 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia PPP3CA 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ppp3ca 35
  • 92.26 (n)
  • 99.62 (a)
(Gallus gallus)
Aves PPP3CA 35
  • 89.22 (n)
  • 98.61 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia PPP3CA 36
  • 98 (a)
African clawed frog
(Xenopus laevis)
Amphibia ppp3ca-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp3ca 35
  • 85.8 (n)
  • 96.93 (a)
Str.15624 35
(Danio rerio)
Actinopterygii Dr.7427 35
ppp3ca 35
  • 75.85 (n)
  • 87.8 (a)
ppp3ca 36
  • 85 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001279 35
  • 66.25 (n)
  • 82.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CanA-14F 36
  • 68 (a)
CanA1 36
  • 60 (a)
Pp2B-14D 35
  • 67.37 (n)
  • 83.05 (a)
Pp2B-14D 36
  • 69 (a)
Pp2B-14D 37
  • 78 (a)
CanA1 37
  • 72 (a)
CanA-14F 37
  • 80 (a)
PpD33 37
  • 80 (a)
(Caenorhabditis elegans)
Secernentea tax-6 35
  • 67.71 (n)
  • 76.62 (a)
tax-6 36
  • 68 (a)
F42G8.8 37
  • 34 (a)
F49E11.7 37
  • 33 (a)
ZC477.2 37
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER118C 35
  • 57.69 (n)
  • 60.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMP2 36
  • 44 (a)
CMP2 38
CNA1 35
  • 58.1 (n)
  • 56.7 (a)
CNA1 36
  • 47 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05489g 35
  • 58.12 (n)
  • 56.25 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03804 35
  • 61.95 (n)
  • 67.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppb1 35
  • 61.25 (n)
  • 65.83 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4524 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8703 36
  • 71 (a)
Species with no ortholog for PPP3CA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CA Gene

Gene Tree for PPP3CA (if available)
Gene Tree for PPP3CA (if available)

Paralogs for PPP3CA Gene

Paralogs for PPP3CA Gene

Selected SIMAP similar genes for PPP3CA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP3CA: view

Variants for PPP3CA Gene

Sequence variations from dbSNP and Humsavar for PPP3CA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs7840 -- 101,023,512(-) AAAAA(A/T)TTCAT utr-variant-3-prime
rs17124 -- 101,058,304(-) TATTT(C/G)TGCTT intron-variant
rs713454 -- 101,226,574(+) GTTCA(C/T)GGTAT intron-variant
rs713455 -- 101,226,488(+) GCTAC(C/G)TGAAG intron-variant
rs750032 -- 101,259,650(-) AATGT(A/G)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3CA Gene

Variant ID Type Subtype PubMed ID
nsv513153 CNV Loss 21212237
nsv820786 CNV Deletion 20802225
dgv888n67 CNV Loss 20364138
nsv820075 CNV Gain 19587683
nsv511238 CNV Loss 21212237
esv2728048 CNV Deletion 23290073
esv29822 CNV Gain+Loss 19812545
esv2674848 CNV Deletion 23128226
dgv5666n71 CNV Loss 21882294
dgv5667n71 CNV Gain 21882294
nsv879675 CNV Loss 21882294
esv2203085 CNV Deletion 18987734
esv2728049 CNV Deletion 23290073
esv2728050 CNV Deletion 23290073
nsv290022 CNV Loss 16902084
esv2728052 CNV Deletion 23290073
esv1177673 CNV Insertion 17803354
nsv518217 CNV Loss 19592680
esv268371 CNV Insertion 20981092
esv2660875 CNV Deletion 23128226
esv2677866 CNV Deletion 23128226
esv28316 CNV Loss 19812545
esv2607263 CNV Insertion 19546169
nsv512832 CNV Insertion 21212237
esv2663140 CNV Deletion 23128226
nsv879676 CNV Loss 21882294
esv2728053 CNV Deletion 23290073
esv2602939 CNV Deletion 19546169
nsv509012 CNV Insertion 20534489
esv2657237 CNV Deletion 23128226

Relevant External Links for PPP3CA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3CA Gene

Disorders for PPP3CA Gene

(2) Novoseek inferred disease relationships for PPP3CA Gene

Disease -log(P) Hits PubMed IDs
osteomyelitis 50.3 1
hypertrophy 17.4 3

Relevant External Links for PPP3CA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PPP3CA: view

No data available for UniProtKB/Swiss-Prot for PPP3CA Gene

Publications for PPP3CA Gene

  1. Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. (PMID: 20590401) Chiocco M.J. … Liu Q.R. (Subst. Use Misuse 2010) 3 4 48
  2. Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). (PMID: 8392375) Muramatsu T. … Kincaid R.L. (Biochim. Biophys. Acta 1993) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PMID: 15671020) Wang Y. … Mizuno K. (J. Biol. Chem. 2005) 3 4

Products for PPP3CA Gene

Sources for PPP3CA Gene

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