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Aliases for PPP3CA Gene

Aliases for PPP3CA Gene

  • Protein Phosphatase 3 Catalytic Subunit Alpha 2 3
  • Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme 2 3 5
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform 3 4
  • CAM-PRP Catalytic Subunit 3 4
  • Calcineurin A Alpha 2 3
  • EC 3.1.3.16 4 63
  • CALNA 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform (Calcineurin A Alpha) 2
  • Protein Phosphatase 2B, Catalytic Subunit, Alpha Isoform 3
  • Protein Phosphatase 3 Catalytic Subunit Alpha Isozyme 3
  • Protein Phosphatase 2B 2
  • Catalytic Subunit 2
  • Alpha Isoform 2
  • CALNA1 3
  • PPP2B 3
  • CCN1 3
  • CNA1 3
  • CALN 3
  • CNA 4

External Ids for PPP3CA Gene

Previous HGNC Symbols for PPP3CA Gene

  • CALN
  • CALNA

Previous GeneCards Identifiers for PPP3CA Gene

  • GC04M102343
  • GC04M102402
  • GC04M102301
  • GC04M102163
  • GC04M101944
  • GC04M097682

Summaries for PPP3CA Gene

GeneCards Summary for PPP3CA Gene

PPP3CA (Protein Phosphatase 3 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP3CA include Osteomyelitis and Viral Esophagitis. Among its related pathways are Axon guidance and HTLV-I infection. GO annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is PPP3CB.

UniProtKB/Swiss-Prot for PPP3CA Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

Gene Wiki entry for PPP3CA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CA Gene

Genomics for PPP3CA Gene

Regulatory Elements for PPP3CA Gene

Enhancers for PPP3CA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP3CA on UCSC Golden Path with GeneCards custom track

Promoters for PPP3CA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP3CA on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP3CA Gene

Chromosome:
4
Start:
101,023,409 bp from pter
End:
101,348,278 bp from pter
Size:
324,870 bases
Orientation:
Minus strand

Genomic View for PPP3CA Gene

Genes around PPP3CA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3CA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CA Gene

Proteins for PPP3CA Gene

  • Protein details for PPP3CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08209-PP2BA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    Protein Accession:
    Q08209
    Secondary Accessions:
    • A1A441
    • A8K3B7
    • A8W6Z7
    • A8W6Z8
    • B5BUA2
    • Q8TAW9

    Protein attributes for PPP3CA Gene

    Size:
    521 amino acids
    Molecular mass:
    58688 Da
    Cofactor:
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity).

    Three dimensional structures from OCA and Proteopedia for PPP3CA Gene

    Alternative splice isoforms for PPP3CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP3CA Gene

Proteomics data for PPP3CA Gene at MOPED

Post-translational modifications for PPP3CA Gene

  • Ubiquitination at Lys 32 and Lys 142
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PPP3CA (Calcineurin A)
  • Cell Signaling Technology (CST) Antibodies for PPP3CA (PPP3CA)

Domains & Families for PPP3CA Gene

Gene Families for PPP3CA Gene

Graphical View of Domain Structure for InterPro Entry

Q08209

UniProtKB/Swiss-Prot:

PP2BA_HUMAN :
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CA: view

Function for PPP3CA Gene

Molecular function for PPP3CA Gene

GENATLAS Biochemistry:
calcineurin A alpha isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,58-59kDa,also abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

Enzyme Numbers (IUBMB) for PPP3CA Gene

Gene Ontology (GO) - Molecular Function for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity NAS 8392375
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity IEA --
GO:0005509 calcium ion binding NAS 8392375
GO:0005515 protein binding IPI 8524402
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP3CA: view
genes like me logo Genes that share phenotypes with PPP3CA: view

Animal Models for PPP3CA Gene

MGI Knock Outs for PPP3CA:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP3CA

miRNA for PPP3CA Gene

miRTarBase miRNAs that target PPP3CA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3CA Gene

Localization for PPP3CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP3CA Gene

Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP3CA Gene COMPARTMENTS Subcellular localization image for PPP3CA gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 4
mitochondrion 3
endoplasmic reticulum 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098794 postsynapse IEA --
genes like me logo Genes that share ontologies with PPP3CA: view

Pathways & Interactions for PPP3CA Gene

genes like me logo Genes that share pathways with PPP3CA: view

Pathways by source for PPP3CA Gene

SIGNOR curated interactions for PPP3CA Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001975 response to amphetamine IEA --
GO:0006470 protein dephosphorylation IEA,NAS 8392375
GO:0006816 calcium ion transport IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
genes like me logo Genes that share ontologies with PPP3CA: view

Drugs & Compounds for PPP3CA Gene

(7) Drugs for PPP3CA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational Pharma Immunosuppressant drug 0
Pimecrolimus Approved, Investigational Pharma 61
MYRISTIC ACID Experimental Pharma Target 0
calcium Nutra 0
Voclosporin Pharma inhibitor 0

(5) Additional Compounds for PPP3CA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(2) ApexBio Compounds for PPP3CA Gene

Compound Action Cas Number
Cyclosporine Immunosuppressant drug 79217-60-0
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3CA: view

Transcripts for PPP3CA Gene

Unigene Clusters for PPP3CA Gene

Protein phosphatase 3, catalytic subunit, alpha isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for PPP3CA Gene

GeneLoc Exon Structure for
PPP3CA
ECgene alternative splicing isoforms for
PPP3CA

Expression for PPP3CA Gene

mRNA expression in normal human tissues for PPP3CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP3CA Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.8), Brain - Caudate (basal ganglia) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for PPP3CA Gene

This gene is overexpressed in Brain (10.0), Lymph node (6.4), and Seminal vesicle (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3CA Gene



SOURCE GeneReport for Unigene cluster for PPP3CA Gene Hs.435512

genes like me logo Genes that share expression patterns with PPP3CA: view

Protein tissue co-expression partners for PPP3CA Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PPP3CA Gene

Orthologs for PPP3CA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP3CA 35
  • 95.65 (n)
  • 99.62 (a)
PPP3CA 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP3CA 35
  • 96.42 (n)
  • 100 (a)
PPP3CA 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp3ca 35
  • 92.71 (n)
  • 99.62 (a)
Ppp3ca 16
Ppp3ca 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP3CA 35
  • 99.3 (n)
  • 99.42 (a)
PPP3CA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp3ca 35
  • 92.26 (n)
  • 99.62 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP3CA 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP3CA 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP3CA 35
  • 89.22 (n)
  • 98.61 (a)
PPP3CA 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP3CA 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp3ca 35
  • 85.8 (n)
  • 96.93 (a)
Str.15624 35
African clawed frog
(Xenopus laevis)
Amphibia ppp3ca-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7427 35
ppp3ca 35
  • 75.85 (n)
  • 87.8 (a)
ppp3ca 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CanA-14F 37
  • 80 (a)
CanA1 37
  • 72 (a)
Pp2B-14D 37
  • 78 (a)
PpD33 37
  • 80 (a)
Pp2B-14D 35
  • 67.37 (n)
  • 83.05 (a)
CanA-14F 36
  • 68 (a)
ManyToMany
CanA1 36
  • 60 (a)
ManyToMany
Pp2B-14D 36
  • 69 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001279 35
  • 66.25 (n)
  • 82.29 (a)
worm
(Caenorhabditis elegans)
Secernentea F42G8.8 37
  • 34 (a)
F49E11.7 37
  • 33 (a)
ZC477.2 37
  • 33 (a)
tax-6 35
  • 67.71 (n)
  • 76.62 (a)
tax-6 36
  • 68 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER118C 35
  • 57.69 (n)
  • 60.26 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05489g 35
  • 58.12 (n)
  • 56.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNA1 35
  • 58.1 (n)
  • 56.7 (a)
CMP2 36
  • 44 (a)
ManyToMany
CNA1 36
  • 47 (a)
ManyToMany
CMP2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4524 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03804 35
  • 61.95 (n)
  • 67.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppb1 35
  • 61.25 (n)
  • 65.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8703 36
  • 71 (a)
OneToMany
Species with no ortholog for PPP3CA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CA Gene

ENSEMBL:
Gene Tree for PPP3CA (if available)
TreeFam:
Gene Tree for PPP3CA (if available)

Paralogs for PPP3CA Gene

Paralogs for PPP3CA Gene

(10) SIMAP similar genes for PPP3CA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP3CA: view

Variants for PPP3CA Gene

Sequence variations from dbSNP and Humsavar for PPP3CA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs7840 -- 101,023,512(-) AAAAA(A/T)TTCAT utr-variant-3-prime
rs17124 -- 101,058,304(-) TATTT(C/G)TGCTT intron-variant
rs978373 -- 101,233,187(+) CTGTC(C/T)AGACA intron-variant
rs713454 -- 101,226,574(+) GTTCA(C/T)GGTAT intron-variant
rs713455 -- 101,226,488(+) GCTAC(C/G)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3CA Gene

Variant ID Type Subtype PubMed ID
nsv513153 CNV Loss 21212237
nsv820786 CNV Deletion 20802225
dgv888n67 CNV Loss 20364138
nsv820075 CNV Gain 19587683
nsv511238 CNV Loss 21212237
esv2728048 CNV Deletion 23290073
esv29822 CNV Gain+Loss 19812545
esv2674848 CNV Deletion 23128226
dgv5666n71 CNV Loss 21882294
dgv5667n71 CNV Gain 21882294
nsv879675 CNV Loss 21882294
esv2203085 CNV Deletion 18987734
esv2728049 CNV Deletion 23290073
esv2728050 CNV Deletion 23290073
nsv290022 CNV Loss 16902084
esv2728052 CNV Deletion 23290073
esv1177673 CNV Insertion 17803354
nsv518217 CNV Loss 19592680
esv268371 CNV Insertion 20981092
esv2660875 CNV Deletion 23128226
esv2677866 CNV Deletion 23128226
esv28316 CNV Loss 19812545
esv2607263 CNV Insertion 19546169
nsv512832 CNV Insertion 21212237
esv2663140 CNV Deletion 23128226
nsv879676 CNV Loss 21882294
esv2728053 CNV Deletion 23290073
esv2602939 CNV Deletion 19546169
nsv509012 CNV Insertion 20534489
esv2657237 CNV Deletion 23128226

Variation tolerance for PPP3CA Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP3CA Gene

Human Gene Mutation Database (HGMD)
PPP3CA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3CA Gene

Disorders for PPP3CA Gene

MalaCards: The human disease database

(12) MalaCards diseases for PPP3CA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteomyelitis
viral esophagitis
alexia
  • acquired dyslexia
benign essential hypertension
erysipeloid
  • infection due to erysipelothrix rhusiopathiae
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP3CA

Genetic Association Database (GAD)
PPP3CA
Human Genome Epidemiology (HuGE) Navigator
PPP3CA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP3CA
genes like me logo Genes that share disorders with PPP3CA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CA Gene

Publications for PPP3CA Gene

  1. Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. (PMID: 20590401) Chiocco M.J. … Liu Q.R. (Subst. Use Misuse 2010) 3 4 48 67
  2. The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT. (PMID: 15671033) RodrA-guez A. … Redondo J.M. (J. Biol. Chem. 2005) 3 23
  3. Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2. (PMID: 11005320) Brogan I.J. … Hutchinson I.V. (Transpl. Immunol. 2000) 3 23
  4. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. (PMID: 9765270) Kashishian A. … Lai Y. (J. Biol. Chem. 1998) 3 23
  5. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively. (PMID: 8978785) Wang M.G. … McBride O.W. (Cytogenet. Cell Genet. 1996) 3 23

Products for PPP3CA Gene

Sources for PPP3CA Gene

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