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Aliases for PPP3CA Gene

Aliases for PPP3CA Gene

  • Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme 2 3
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform 3 4
  • CAM-PRP Catalytic Subunit 3 4
  • Calcineurin A Alpha 2 3
  • EC 4 63
  • CALNA 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Alpha Isoform (Calcineurin A Alpha) 2
  • Protein Phosphatase 2B, Catalytic Subunit, Alpha Isoform 3
  • Protein Phosphatase 2B 2
  • Catalytic Subunit 2
  • Alpha Isoform 2
  • CALNA1 3
  • PPP2B 3
  • CCN1 3
  • CNA1 3
  • CALN 3
  • CNA 4

External Ids for PPP3CA Gene

Previous HGNC Symbols for PPP3CA Gene

  • CALN

Previous GeneCards Identifiers for PPP3CA Gene

  • GC04M102343
  • GC04M102402
  • GC04M102301
  • GC04M102163
  • GC04M101944
  • GC04M097682

Summaries for PPP3CA Gene

GeneCards Summary for PPP3CA Gene

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, Alpha Isozyme) is a Protein Coding gene. Diseases associated with PPP3CA include viral esophagitis and alexia. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is PPP3CB.

UniProtKB/Swiss-Prot for PPP3CA Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

Gene Wiki entry for PPP3CA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CA Gene

Genomics for PPP3CA Gene

Regulatory Elements for PPP3CA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP3CA Gene

101,023,409 bp from pter
101,348,278 bp from pter
324,870 bases
Minus strand

Genomic View for PPP3CA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP3CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CA Gene

Proteins for PPP3CA Gene

  • Protein details for PPP3CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    Protein Accession:
    Secondary Accessions:
    • A1A441
    • A8K3B7
    • A8W6Z7
    • A8W6Z8
    • B5BUA2
    • Q8TAW9

    Protein attributes for PPP3CA Gene

    521 amino acids
    Molecular mass:
    58688 Da
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Note=Binds 1 Fe(3+) ion per subunit.;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts with CHP1 and CHP2 (By similarity). Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle (By similarity).

    Three dimensional structures from OCA and Proteopedia for PPP3CA Gene

    Alternative splice isoforms for PPP3CA Gene


neXtProt entry for PPP3CA Gene

Proteomics data for PPP3CA Gene at MOPED

Post-translational modifications for PPP3CA Gene

  • Ubiquitination at Lys 32 and Lys 142
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PPP3CA (Calcineurin A)
  • Cell Signaling Technology (CST) Antibodies for PPP3CA (PPP3CA)

Domains & Families for PPP3CA Gene

Gene Families for PPP3CA Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PPP phosphatase family. PP-2B subfamily.
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CA: view

Function for PPP3CA Gene

Molecular function for PPP3CA Gene

GENATLAS Biochemistry:
calcineurin A alpha isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,58-59kDa,also abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

Enzyme Numbers (IUBMB) for PPP3CA Gene

Gene Ontology (GO) - Molecular Function for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity NAS 8392375
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity --
GO:0005509 calcium ion binding NAS 8392375
GO:0005515 protein binding IPI 8524402
genes like me logo Genes that share ontologies with PPP3CA: view
genes like me logo Genes that share phenotypes with PPP3CA: view

Animal Models for PPP3CA Gene

MGI Knock Outs for PPP3CA:

Animal Model Products

miRNA for PPP3CA Gene

miRTarBase miRNAs that target PPP3CA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP3CA

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PPP3CA Gene

Localization for PPP3CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP3CA Gene

Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PPP3CA Gene COMPARTMENTS Subcellular localization image for PPP3CA gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 3
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP3CA: view

Pathways & Interactions for PPP3CA Gene

genes like me logo Genes that share pathways with PPP3CA: view

PCR Array Products

SIGNOR curated interactions for PPP3CA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PPP3CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001975 response to amphetamine IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006470 protein dephosphorylation NAS 8392375
GO:0006606 protein import into nucleus IEA --
genes like me logo Genes that share ontologies with PPP3CA: view

Drugs & Compounds for PPP3CA Gene

(7) Drugs for PPP3CA Gene - From: ApexBio, DGIdb, NovoSeek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational Pharma Immunosuppressant drug 0
Pimecrolimus Approved, Investigational Pharma 60
Tacrolimus Approved, Investigational Pharma 992
MYRISTIC ACID Experimental Pharma Target 0
Calcium Nutra 0

(5) Additional Compounds for PPP3CA Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PPP3CA: view

Transcripts for PPP3CA Gene

Unigene Clusters for PPP3CA Gene

Protein phosphatase 3, catalytic subunit, alpha isozyme:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP3CA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP2: -
SP3: - -
SP4: - -

Relevant External Links for PPP3CA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP3CA Gene

mRNA expression in normal human tissues for PPP3CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP3CA Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.8), Brain - Caudate (basal ganglia) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for PPP3CA Gene

This gene is overexpressed in Brain (10.0), Lymph node (6.4), and Seminal vesicle (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP3CA Gene

SOURCE GeneReport for Unigene cluster for PPP3CA Gene Hs.435512

genes like me logo Genes that share expression patterns with PPP3CA: view

Protein tissue co-expression partners for PPP3CA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PPP3CA Gene

Orthologs for PPP3CA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP3CA 35
  • 95.65 (n)
  • 99.62 (a)
  • 100 (a)
(Canis familiaris)
Mammalia PPP3CA 35
  • 96.42 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Ppp3ca 35
  • 92.71 (n)
  • 99.62 (a)
Ppp3ca 16
Ppp3ca 36
  • 100 (a)
(Pan troglodytes)
Mammalia PPP3CA 35
  • 99.3 (n)
  • 99.42 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppp3ca 35
  • 92.26 (n)
  • 99.62 (a)
(Monodelphis domestica)
Mammalia PPP3CA 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia PPP3CA 36
  • 98 (a)
(Gallus gallus)
Aves PPP3CA 35
  • 89.22 (n)
  • 98.61 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia PPP3CA 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp3ca 35
  • 85.8 (n)
  • 96.93 (a)
Str.15624 35
African clawed frog
(Xenopus laevis)
Amphibia ppp3ca-prov 35
(Danio rerio)
Actinopterygii Dr.7427 35
ppp3ca 35
  • 75.85 (n)
  • 87.8 (a)
ppp3ca 36
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CanA-14F 37
  • 80 (a)
CanA1 37
  • 72 (a)
Pp2B-14D 37
  • 78 (a)
PpD33 37
  • 80 (a)
Pp2B-14D 35
  • 67.37 (n)
  • 83.05 (a)
CanA-14F 36
  • 68 (a)
CanA1 36
  • 60 (a)
Pp2B-14D 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001279 35
  • 66.25 (n)
  • 82.29 (a)
(Caenorhabditis elegans)
Secernentea F42G8.8 37
  • 34 (a)
F49E11.7 37
  • 33 (a)
ZC477.2 37
  • 33 (a)
tax-6 35
  • 67.71 (n)
  • 76.62 (a)
tax-6 36
  • 68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER118C 35
  • 57.69 (n)
  • 60.26 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05489g 35
  • 58.12 (n)
  • 56.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNA1 35
  • 58.1 (n)
  • 56.7 (a)
CMP2 36
  • 44 (a)
CNA1 36
  • 47 (a)
CMP2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4524 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03804 35
  • 61.95 (n)
  • 67.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppb1 35
  • 61.25 (n)
  • 65.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8703 36
  • 71 (a)
Species with no ortholog for PPP3CA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CA Gene

Gene Tree for PPP3CA (if available)
Gene Tree for PPP3CA (if available)

Paralogs for PPP3CA Gene

Paralogs for PPP3CA Gene

(10) SIMAP similar genes for PPP3CA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP3CA: view

Variants for PPP3CA Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP3CA Gene

Variant ID Type Subtype PubMed ID
nsv513153 CNV Loss 21212237
nsv820786 CNV Deletion 20802225
dgv888n67 CNV Loss 20364138
nsv820075 CNV Gain 19587683
nsv511238 CNV Loss 21212237
esv2728048 CNV Deletion 23290073
esv29822 CNV Gain+Loss 19812545
esv2674848 CNV Deletion 23128226
dgv5666n71 CNV Loss 21882294
dgv5667n71 CNV Gain 21882294
nsv879675 CNV Loss 21882294
esv2203085 CNV Deletion 18987734
esv2728049 CNV Deletion 23290073
esv2728050 CNV Deletion 23290073
nsv290022 CNV Loss 16902084
esv2728052 CNV Deletion 23290073
esv1177673 CNV Insertion 17803354
nsv518217 CNV Loss 19592680
esv268371 CNV Insertion 20981092
esv2660875 CNV Deletion 23128226
esv2677866 CNV Deletion 23128226
esv28316 CNV Loss 19812545
esv2607263 CNV Insertion 19546169
nsv512832 CNV Insertion 21212237
esv2663140 CNV Deletion 23128226
nsv879676 CNV Loss 21882294
esv2728053 CNV Deletion 23290073
esv2602939 CNV Deletion 19546169
nsv509012 CNV Insertion 20534489
esv2657237 CNV Deletion 23128226

Variation tolerance for PPP3CA Gene

Residual Variation Intolerance Score: 18.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP3CA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PPP3CA Gene

Disorders for PPP3CA Gene

MalaCards: The human disease database

(7) MalaCards diseases for PPP3CA Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
viral esophagitis
  • acquired dyslexia
benign essential hypertension
  • infection due to erysipelothrix rhusiopathiae
- elite association

Relevant External Links for PPP3CA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPP3CA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CA Gene

Publications for PPP3CA Gene

  1. Cell surface hydrophobicity, biofilm formation, adhesives properties and molecular detection of adhesins genes in Staphylococcus aureus associated to dental caries. (PMID: 20298773) Kouidhi B. … Bakhrouf A. (Microb. Pathog. 2010) 23 67
  2. Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis. (PMID: 19151325) Idnurm A. … Heitman J. (Eukaryotic Cell 2009) 23 67
  3. Distribution of meticillin-resistant Staphylococcus aureus spa types isolated from health-care workers and patients in a Scottish university teaching hospital. (PMID: 19528147) Soliman R.S. … Edwards D.H. (J. Med. Microbiol. 2009) 23 67
  4. Calcineurin regulatory subunit B is a unique calcium sensor that regulates calcineurin in both calcium-dependent and calcium-independent manner. (PMID: 19536897) Li J. … Wei Q. (Proteins 2009) 23 67
  5. Molecular epidemiology of Staphylococcus aureus in asymptomatic carriers. (PMID: 19434432) Monecke S. … Ehricht R. (Eur. J. Clin. Microbiol. Infect. Dis. 2009) 23 67

Products for PPP3CA Gene

Sources for PPP3CA Gene

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