Aliases for PPP2R5E Gene
- Protein Phosphatase 2 Regulatory Subunit B', Epsilon 2
- Protein Phosphatase 2 Regulatory Subunit B, Epsilon 2 3 5
- Protein Phosphatase 2, Regulatory Subunit B (B56), Epsilon Isoform 2
- PP2A B Subunit Isoform PR61-Epsilon 4
- PP2A B Subunit Isoform B56-Epsilon 4
- PP2A B Subunit Isoform R5-Epsilon 4
- PP2A B Subunit Isoform B-Epsilon 4
External Ids for PPP2R5E Gene
Previous GeneCards Identifiers for PPP2R5E Gene
The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for PPP2R5E Gene
PPP2R5E (Protein Phosphatase 2 Regulatory Subunit B', Epsilon) is a Protein Coding gene. Diseases associated with PPP2R5E include Breast Disease. Among its related pathways are CTLA4 Signaling and Negative regulation of MAPK pathway. GO annotations related to this gene include binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5A.
UniProtKB/Swiss-Prot for PPP2R5E Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.