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PPP2R5E Gene

protein-coding   GIFtS: 63
GCID: GC14M063838

Protein Phosphatase 2, Regulatory Subunit B', Epsilon Isoform

(Previous names: protein phosphatase 2, regulatory subunit B (B56), epsilon...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Phosphatase 2, Regulatory Subunit B', Epsilon Isoform1 2     PP2A, B Subunit, B' Epsilon2
Protein Phosphatase 2, Regulatory Subunit B (B56), Epsilon Isoform1 2     PP2A, B Subunit, B56 Epsilon2
PP2A B Subunit Isoform B'-Epsilon2 3     PP2A, B Subunit, PR61 Epsilon2
PP2A B Subunit Isoform B56-Epsilon2 3     PP2A, B Subunit, R5 Epsilon2
PP2A B Subunit Isoform PR61-Epsilon2 3     Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit,
Epsilon2
PP2A B Subunit Isoform R5-Epsilon2 3     Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Epsilon
Isoform2
Epsilon Isoform Of Regulatory Subunit B56, Protein Phosphatase 2A2     

External Ids:    HGNC: 93131   Entrez Gene: 55292   Ensembl: ENSG000001540017   OMIM: 6016475   UniProtKB: Q165373   
ORGUL members:         

Export aliases for PPP2R5E gene to outside databases

Previous GC identifers: GC14M061168 GC14M057635 GC14M061831 GC14M062911 GC14M044007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R5E Gene:
The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A
is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and
division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a
constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit
might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the
regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been
found for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for PPP2R5E Gene:
PPP2R5E (protein phosphatase 2, regulatory subunit B', epsilon isoform) is a protein-coding gene. Diseases associated with PPP2R5E include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5D.

UniProtKB/Swiss-Prot: 2A5E_HUMAN, Q16537
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Wiki entry for PPP2R5E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R5E gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F1   POU2F1a   FOXO1a   MRF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2R5E promoter sequence
   Search Chromatin IP Primers for PPP2R5E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R5E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.2   HGNC cytogenetic band: 14q23.2

PPP2R5E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5E gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M063838:  view genomic region     (about GC identifiers)

Start:
63,838,075 bp from pter      End:
64,010,092 bp from pter
Size:
172,018 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 2A5E_HUMAN, Q16537 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform  
Size: 467 amino acids; 54699 Da
Subunit: Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A
consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa
constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins
that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,
R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell
signaling molecules. Interacts with SGOL1
Secondary accessions: A4FU37 B7ZKK8 Q52LW4

Explore the universe of human proteins at neXtProt for PPP2R5E: NX_Q16537

Explore proteomics data for PPP2R5E at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP2R5E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001269108.1  NP_001269109.1  NP_001269110.1  NP_001269111.1  NP_006237.1  

    ENSEMBL proteins: 
     ENSP00000337641   ENSP00000452396   ENSP00000404632  
    Reactome Protein details: Q16537

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    2 InterPro protein domains:
     IPR002554 PP2A_B56
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q16537

    ProtoNet protein and cluster: Q16537

    1 Blocks protein domain: IPB002554 Protein phosphatase 2A

    UniProtKB/Swiss-Prot: 2A5E_HUMAN, Q16537
    Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family


    PPP2R5E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2A5E_HUMAN, Q16537
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment

         Genatlas biochemistry entry for PPP2R5E:
    protein phosphatase 2A,regulatory subunit B56 epsilon isoform,expressed in brain

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15380617
    GO:0008601protein phosphatase type 2A regulator activity IEA--
         
    PPP2R5E for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PPP2R5E:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased Erk phosphorylation   Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R5E
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    miRNA
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    miRTarBase miRNAs that target PPP2R5E:
    hsa-mir-125a-5p (MIRT045699), hsa-let-7c-5p (MIRT051753), hsa-let-7b-5p (MIRT051983), hsa-mir-365a-3p (MIRT044037)

    Block miRNA regulation of human, mouse, rat PPP2R5E using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R5E (see all 86):
    hsa-miR-548j hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-1258 hsa-miR-502-3p hsa-miR-1244 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5E 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    2A5E_HUMAN, Q16537: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle ----

    PPP2R5E for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R5E About   (see all 39)  
    See pathways by source

    SuperPathContained pathways About
    1CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    CTLA4 inhibitory signaling0.32
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    5Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R5E (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    4 GeneGo (Thomson Reuters) Pathways for PPP2R5E
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5 BioSystems Pathways for PPP2R5E
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Glycogen Metabolism
    IL-6 Signaling Pathway


    Selected Reactome Pathways for PPP2R5E (see all 8)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    CTLA4 inhibitory signaling


    5 Kegg Pathways  (Kegg details for PPP2R5E):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Dopaminergic synapse


    PPP2R5E for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R5E
    Interactions:

        Search GeneGlobe Interaction Network for PPP2R5E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R5E (Q165371, 2, 3 ENSP000003376414) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DZIP1Q86YF91, 2EBI-968374,EBI-998108 MINT-8287380 MINT-8287338 MINT-8287366
    PPP2R1BP301541, 3, ENSP000003113444EBI-968374,EBI-357094 I2D: score=3 STRING: ENSP00000311344
    CHEK2O960171, 3, ENSP000003720234EBI-968374,EBI-1180783 I2D: score=2 STRING: ENSP00000372023
    PPP2R1AP301531, 3, ENSP000003248044EBI-968374,EBI-302388 I2D: score=2 STRING: ENSP00000324804
    SMAD9O151982, 3MINT-62118 I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0050790regulation of catalytic activity TAS8703017

    PPP2R5E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP2R5E (2A5E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R5E gene (5 alternative transcripts): 
    NM_001282179.1  NM_001282180.1  NM_001282181.1  NM_001282182.1  NM_006246.3  

    Unigene Cluster for PPP2R5E:

    Protein phosphatase 2, regulatory subunit B', epsilon isoform
    Hs.334868  [show with all ESTs]
    Unigene Representative Sequence: BC056156
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337537(uc010tsf.1 uc010tsg.1 uc001xgd.1 uc010tsh.1 uc001xge.2 uc001xgf.1)
    ENST00000555899 ENST00000556484 ENST00000553266 ENST00000556150 ENST00000556878(uc001xgg.4)
    ENST00000422769
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate PPP2R5E (see all 86):
    hsa-miR-548j hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-1258 hsa-miR-502-3p hsa-miR-1244 hsa-miR-548a-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5E
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R5E

    Additional mRNA sequence: 

    AB209811.1 AB451233.1 AB451358.1 AK299520.1 AK301796.1 AK313500.1 AK316430.1 BC013154.1 
    BC048305.1 BC056156.1 BC064358.1 BC073873.1 BC092477.1 BC093766.1 BC101479.1 BC143231.1 
    BC143234.1 L76703.1 Z69029.1 

    11 DOTS entries:

    DT.216245  DT.91931600  DT.101961804  DT.91742226  DT.121079199  DT.120786190  DT.100684867  DT.102833225 
    DT.95263476  DT.95355537  DT.121432529 

    Selected AceView cDNA sequences (see all 243):

    AW134792 BC048305 AI431346 NM_006246 CA440763 BX279762 AA605237 AA831320 
    AI308971 BM999907 AI288887 H86476 AA233878 BI087065 CB121021 BU179084 
    AI080678 AA587188 BC056156 BG676450 F09681 AW439428 BI858153 CD676351 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5E (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
    SP1:              -     -     -           -                                                                                             
    SP2:              -     -     -           -                                                                                             
    SP3:              -     -     -     -     -                                                                                             
    SP4:                          -           -                                                                                             
    SP5:                                      -                                                                                             


    ECgene alternative splicing isoforms for PPP2R5E

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R5E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACAGTGTT
    PPP2R5E Expression
    About this image

    PPP2R5E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R5E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334868
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R5E gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r5e1 , 5 protein phosphatase 2, regulatory subunit B (B56), more5
    protein phosphatase 2, regulatory subunit B', epsilon1
    95.86(n)1
    99.79(a)1
      12 (32.75 cM)5
    269321  NM_012024.21  NP_036154.11 
     754508835 
    chicken
    (Gallus gallus)
    Aves PPP2R5E1 protein phosphatase 2, regulatory subunit B', epsilon more 92.36(n)
    100(a)
      423512  XM_421412.4  XP_421412.2 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R5E6
    protein phosphatase 2, regulatory subunit B', epsi...
    100(a)
    1 ↔ 1
    1(2232043-2317747)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69382 Xenopus laevis protein phosphatase-2A B'epsilon subunit more 87.46(n)    AF298157.1 
    zebrafish
    (Danio rerio)
    Actinopterygii efnb32 ephrin B3 80.53(n)   373878  BC048034.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD343433
    wdb1
    protein serine/threonine phosphatase3
    widerborst1
    77(a)
    (best of 2)3
    64.14(n)1
    76.17(a)1
      98A63
    433121  NM_170337.31  NP_733216.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W08G11.43
    pptr-11
    RTS1 PROTEIN (SCS1 PROTEIN)3
    pptr-11
    67(a)3
    61.32(n)1
    67.25(a)1
      V(16360199-16362996)3
    1801001  NM_074732.51  NP_507133.41 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS16
    B-type regulatory subunit of protein phosphatase 2...
    33(a)
    1 → many
    XV(357674-359947) YOR014W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATB' BETA1 ATB' BETA 57.41(n)
    56.3(a)
      820146  NM_111823.2  NP_187599.1 


    ENSEMBL Gene Tree for PPP2R5E (if available)
    TreeFam Gene Tree for PPP2R5E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R5E gene
    PPP2R5D2  PPP2R5B2  PPP2R5A2  PPP2R5C2  
    4 SIMAP similar genes for PPP2R5E using alignment to 7 protein entries:     2A5E_HUMAN (see all proteins):
    PPP2R5A    PPP2R5B    PPP2R5C    PPP2R5D

    PPP2R5E for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R5E (see all 3829)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355873121,2
    C--44827735(+) ATAAG-/AT    
       
    /ATAT
    ATATA
    1 -- ds50011NA 2
    rs1461556511,2
    C--63840957(+) GCTTC-/TCTT  
            
    TCTTT
    1 -- ds50010--------
    rs1830468041,2
    --63840961(+) CTCTTC/TCTTTT 1 -- ds50010--------
    rs1180228411,2
    C,F--63841100(+) CACAAT/ATCAAC 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1389892481,2
    C--63841355(+) AAGAT-/ATATATATA
    TATATATATATA
    TATAT
    1 -- cds10--------
    rs2019551711,2
    C--63841404(+) TAGAT-/TTTG  
            
    TTTTT
    1 -- ut310--------
    rs37426241,2
    C,F,H--63841891(-) AAATGT/CGAGAA 1 -- ut3121Minor allele frequency- C:0.38EA NS NA WA CSA 3812
    rs1868357491,2
    --63841980(+) TGCCTC/GTTTTC 1 -- ut310--------
    rs37426231,2
    C,F--63841992(-) CTTGAA/GTCCTT 1 -- ut31 ese31Minor allele frequency- G:0.02EA 1474
    rs1388753991,2
    C--63842056(+) TACTAC/TGTTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPP2R5E (63838075 - 64010092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPP2R5E (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3298CNV Deletion18987735
    esv2748776CNV Deletion23290073
    esv2670321CNV Deletion23128226
    esv2748777CNV Deletion23290073
    esv2673552CNV Deletion23128226
    esv2748775CNV Deletion23290073
    esv2533003CNV Deletion19546169
    esv2120827CNV Deletion18987734
    esv2659005CNV Deletion23128226
    esv2657638CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R5E
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R5E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601647    OMIM disorders: --

    13 diseases for PPP2R5E:    
    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    breast disease
    cerebritis    kaposi's sarcoma    crohn's disease    chronic lymphocytic leukemia
    sarcoma    hiv-1    leukemia    breast cancer
    malaria


    PPP2R5E for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP2R5E
    Human Genome Epidemiology (HuGE) Navigator: PPP2R5E (2 documents)

    Export disorders for PPP2R5E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R5E gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with PPP2R5E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PubMed id 21659360)1, 4 Wade R....Houlston R.S. (Haematologica 2011)
    2. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PubMed id 19890961)1, 4 Dupont W.D....Smith J.R. (Cancer 2010)
    3. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PubMed id 8703017)1, 2 McCright B.... Virshup D.M. (J. Biol. Chem. 1996)
    6. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PubMed id 8694763)1, 2 Zolnierowicz S.... Hemmings B.A. (Biochem. J. 1996)
    7. Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)1, 3 McCright B. and Virshup D.M. (J. Biol. Chem. 1995)
    8. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5529 HGNC: 9313 AceView: PPP2R5E Ensembl:ENSG00000154001 euGenes: HUgn5529
    ECgene: PPP2R5E Kegg: 5529 H-InvDB: PPP2R5E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R5E Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R5E Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R5E gene:
    Search GeneIP for patents involving PPP2R5E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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