Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP2R5D Gene

protein-coding   GIFtS: 63
GCID: GC06P042952

Protein Phosphatase 2, Regulatory Subunit B', Delta

(Previous names: protein phosphatase 2, regulatory subunit B (B56), delta...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 2, Regulatory Subunit B', Delta1 2     B56D2
Protein Phosphatase 2, Regulatory Subunit B (B56), Delta Isoform1 2     PP2A, B Subunit, B' Delta Isoform2
Protein Phosphatase 2, Regulatory Subunit B', Delta Isoform1 2     PP2A, B Subunit, B56 Delta Isoform2
PP2A B Subunit Isoform B'-Delta2 3     PP2A, B Subunit, PR61 Delta Isoform2
PP2A B Subunit Isoform B56-Delta2 3     PP2A, B Subunit, R5 Delta Isoform2
PP2A B Subunit Isoform PR61-Delta2 3     Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Delta
Isoform2
PP2A B Subunit Isoform R5-Delta2 3     Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Delta
Isoform2

External Ids:    HGNC: 93121   Entrez Gene: 55282   Ensembl: ENSG000001126407   OMIM: 6016465   UniProtKB: Q147383   

Export aliases for PPP2R5D gene to outside databases

Previous GC identifers: GC06P042954 GC06P042999 GC06P043060 GC06P042669


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R5D Gene:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one
of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant
regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might
modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory
subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R5D Gene: 
PPP2R5D (protein phosphatase 2, regulatory subunit B', delta) is a protein-coding gene. Diseases associated with PPP2R5D include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are MAP kinase activation in TLR cascade and Mitotic Anaphase. GO annotations related to this gene include protein binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5B.

UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Wiki entry for PPP2R5D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP2R5D gene promoter:
         E2F-4   E2F-3a   STAT1   E2F-5   E2F-2   Evi-1   Egr-2   E2F   E2F-1   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2R5D promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP2R5D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

PPP2R5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5D gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042952:  view genomic region     (about GC identifiers)

Start:
42,952,237 bp from pter      End:
42,980,080 bp from pter
Size:
27,844 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform  
Size: 602 amino acids; 69992 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Interacts with SGOL1
Subcellular location: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis
Secondary accessions: A8K3I9 B5BUA6 O00494 O00696 Q15171 Q5TC39
Alternative splicing: 3 isoforms:  Q14738-1   Q14738-2   Q14738-3   

Explore the universe of human proteins at neXtProt for PPP2R5D: NX_Q14738

Explore proteomics data for PPP2R5D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14738

  • PPP2R5D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP2R5D Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001257405.1  NP_006236.1  NP_851307.1  NP_851308.1  

    ENSEMBL proteins: 
     ENSP00000417963   ENSP00000377669   ENSP00000420550   ENSP00000230402   ENSP00000420674  
     ENSP00000419756   ENSP00000420529  
    Reactome Protein details: Q14738
    Human Recombinant Protein Products for PPP2R5D: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPP2R5D
    OriGene Protein Over-expression Lysate for PPP2R5D
    OriGene MassSpec for PPP2R5D 
    OriGene Custom Protein Services for PPP2R5D
    GenScript Custom Purified and Recombinant Proteins Services for PPP2R5D
    Novus Biologicals PPP2R5D Proteins
    Novus Biologicals PPP2R5D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex IEA--
    GO:0005634nucleus TAS8703017
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    PPP2R5D for ontologies           About GeneDecksing



    PPP2R5D Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2R5D
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PPP2R5D 
    OriGene Antibodies for PPP2R5D
    OriGene Custom Antibody Services for PPP2R5D
    GenScript Custom Superior Antibodies Services for PPP2R5D
    Novus Biologicals PPP2R5D Antibodies
    Abcam antibodies for PPP2R5D
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PPP2R5D
    LSBio Antibodies in human, mouse, rat for PPP2R5D 

    Assay Products for PPP2R5D: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP2R5D
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP2R5D
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    2 InterPro protein domains:
     IPR002554 PP2A_B56
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q14738

    ProtoNet protein and cluster: Q14738

    1 Blocks protein domain: IPB002554 Protein phosphatase 2A

    UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738
    Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family


    PPP2R5D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2A5D_HUMAN, Q14738
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment
    Induction: By retinoic acid; in neuroblastoma cell lines

         Genatlas biochemistry entry for PPP2R5D:
    protein phosphatase 2A,regulatory subunit B56 delta isoform,expressed in adult brain,cytosolic subunit of PPPR2A
    in interphase cells,concentrated in the nucleus of mitotic and recently divided cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity TAS--
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
    GO:0008601protein phosphatase type 2A regulator activity IEA--
         
    PPP2R5D for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPP2R5D:
     Decreased focal adhesion (FA)   Decreased number of cells in m  Decreased viability of wild-ty 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ppp2r5d):
     behavior/neurological  integument  mortality/aging  nervous system 

    PPP2R5D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp2r5dtm1Vjan for PPP2R5D

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP2R5D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP2R5D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R5D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R5D 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP2R5D
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2R5D (see all 26):
    hsa-miR-148b* hsa-miR-1321 hsa-miR-328 hsa-miR-1205 hsa-miR-3605-5p hsa-miR-9 hsa-miR-4274 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5D 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP2R5D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2R5D

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP2R5D
    Sirion Biotech Customized adenovirus for overexpression of PPP2R5D

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PPP2R5D (see all 19)
    OriGene ORF clones in mouse, rat for PPP2R5D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPP2R5D (NM_006245)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R5D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R5D
    Sirion Biotech Customized lentivirus for stable overexpression of PPP2R5D 
                         Customized lentivirus expression plasmids for stable overexpression of PPP2R5D 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP2R5D
    Search LifeMap BioReagents cell lines for PPP2R5D
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP2R5D About   (see all 43)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3ERK/MAPK targets
    ERK/MAPK targets0.88
    ERKs are inactivated0.57
    Nuclear Events (kinase and transcription factor activation)0.88
    PP2A-mediated dephosphorylation of key metabolic factors0.36
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    5Platelet sensitization by LDL
    Platelet sensitization by LDL0.39
    CTLA4 inhibitory signaling0.34
    Beta-catenin phosphorylation cascade0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PPP2R5D
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Signal transduction PKA signaling

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2R5D (see all 9)
        Telomerase Components in Cell Signaling
    TGF-Beta Pathway
    mTOR Pathway
    p70S6K Signaling
    ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for PPP2R5D
        Phosphatases

    4 GeneGo (Thomson Reuters) Pathways for PPP2R5D
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/8 BioSystems Pathways for PPP2R5D (see all 8)
        Glycogen Metabolism
    IL-6 Signaling Pathway
    Aurora B signaling
    Alpha-synuclein signaling
    Presenilin action in Notch and Wnt signaling

    5/55        Reactome Pathways for PPP2R5D (see all 55)
        Mitotic Prometaphase
    Toll Like Receptor 2 (TLR2) Cascade
    Costimulation by the CD28 family
    Toll Like Receptor TLR6:TLR2 Cascade
    Platelet homeostasis


    4         Kegg Pathways  (Kegg details for PPP2R5D):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Dopaminergic synapse


    PPP2R5D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP2R5D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for PPP2R5D (Q147381, 2, 3 ENSP000004179634) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1BP301541, 3, ENSP000003113444EBI-396563,EBI-357094 I2D: score=3 STRING: ENSP00000311344
    SGOL1Q5FBB72, 3, ENSP000002637534MINT-8295766 I2D: score=3 STRING: ENSP00000263753
    PPP2R1AP301531, 3, ENSP000003248044EBI-396563,EBI-302388 I2D: score=2 STRING: ENSP00000324804
    PPFIA1Q131361, 2, 3, ENSP000002539254EBI-396563,EBI-745426 MINT-66659 I2D: score=6 STRING: ENSP00000253925
    SGOL2Q562F62, 3, ENSP000003504474MINT-8212557 I2D: score=2 STRING: ENSP00000350447
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--

    PPP2R5D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PPP2R5D:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP2R5D (2A5D)

    Search CenterWatch for drugs/clinical trials and news about PPP2R5D / 2A5D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP2R5D gene (4 alternative transcripts): 
    NM_001270476.1  NM_006245.3  NM_180976.2  NM_180977.2  

    Unigene Cluster for PPP2R5D:

    Protein phosphatase 2, regulatory subunit B', delta
    Hs.533308  [show with all ESTs]
    Unigene Representative Sequence: NM_001270476
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485511(uc003oth.3 uc011dva.2 uc003otj.3) ENST00000394110(uc021yzq.1 uc010jyd.3)
    ENST00000472118 ENST00000230402(uc003oti.3) ENST00000461010 ENST00000470467
    ENST00000467447 ENST00000482315 ENST00000486843
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP2R5D
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2R5D (see all 26):
    hsa-miR-148b* hsa-miR-1321 hsa-miR-328 hsa-miR-1205 hsa-miR-3605-5p hsa-miR-9 hsa-miR-4274 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5D 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP2R5D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2R5D
    Clone
    Products:
         
    OriGene clones in human, mouse for PPP2R5D (see all 19)
    OriGene ORF clones in mouse, rat for PPP2R5D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPP2R5D (NM_006245)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R5D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R5D
    Sirion Biotech Customized lentivirus for stable overexpression of PPP2R5D 
                         Customized lentivirus expression plasmids for stable overexpression of PPP2R5D 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPP2R5D
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R5D
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP2R5D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R5D

    Additional mRNA sequence: 

    AB000634.1 AB000635.1 AB209861.1 AB451342.1 AB451357.1 AK122701.1 AK290604.1 AK291797.1 
    AK299696.1 BC001095.2 BC001175.1 BC010692.1 D78360.1 L76702.1 

    20 DOTS entries:

    DT.100677856  DT.101976805  DT.40124305  DT.95272009  DT.100816629  DT.100816626  DT.92454606  DT.100816630 
    DT.121385635  DT.95272008  DT.100816627  DT.92454595  DT.100816631  DT.100816632  DT.121385651  DT.121385661 
    DT.99945016  DT.100816633  DT.121385662  DT.97854895 

    24/971 AceView cDNA sequences (see all 971):

    AB000634 NM_006245 BU846070 CR598438 CF264682 BQ644624 BC012987 BI260022 
    BI754668 AA777245 BQ063092 BM662665 BP371234 BM450526 AI891071 BQ671461 
    BM924443 BM721348 BG179476 BQ056358 BQ673110 BM972160 CR625285 AI208409 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5D (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a ·
    SP1:                                      -                                                                             -                                       
    SP2:                                -     -     -     -     -     -                                                     -                                       
    SP3:                                      -                 -     -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                      -     -                                                                                                               

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PPP2R5D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP2R5D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAGGTGGG
    PPP2R5D Expression
    About this image


    See PPP2R5D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP2R5D

    SOURCE GeneReport for Unigene cluster: Hs.533308

    UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738
    Tissue specificity: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain

        SABiosciences Custom PCR Arrays for PPP2R5D
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPP2R5D
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R5D
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP2R5D
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5D
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R5D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R5D gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r5d1 , 5 protein phosphatase 2, regulatory subunit B (B56), more1, 5 90.74(n)1
    97.31(a)1
      17 (22.90 cM)5
    217701  NM_009358.31  NP_033384.21 
     466829915 
    chicken
    (Gallus gallus)
    Aves PPP2R5D1 protein phosphatase 2, regulatory subunit B', delta 80.26(n)
    93.06(a)
      421250  XM_419321.3  XP_419321.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R5D6
    protein phosphatase 2, regulatory subunit B', delt...
    89(a)
    1 ↔ 1
    2(144796668-144850743)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc41e122 Danio rerio cDNA clone MGC73160 IMAGE4144870, complete more 83.47(n)    BC064705.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PP2A-B'1 , 3 protein amino acid dephosphorylation
    protein phosphatase more3
    CG7913-PA1
    75(a)
    (best of 2)3
    66.35(n)1
    70.4(a)1
      90F13
    421691  NM_169789.21  NP_732295.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C13G3.3b3
    pptr-21
    Protein PPTR-21 65(a)
    (best of 3)3
    59.11(n)1
    64.01(a)1
      V(11030109-11031978)3
    1795261  NM_001129373.11  NP_001122845.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS16
    B-type regulatory subunit of protein phosphatase 2...
    36(a)
    1 → many
    XV(357674-359947)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATB' GAMMA1 protein phosphatase 2 (formerly 2A), regulatory subunit more 52.89(n)
    50.83(a)
      827211  NM_179059.1  NP_849390.1 
    rice
    (Oryza sativa)
    Liliopsida AK101208.12   -- 74.55(n)    AK101208.1 


    ENSEMBL Gene Tree for PPP2R5D (if available)
    TreeFam Gene Tree for PPP2R5D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP2R5D gene
    PPP2R5B2  PPP2R5A2  PPP2R5C2  PPP2R5E2  
    4 SIMAP similar genes for PPP2R5D using alignment to 5 protein entries:     2A5D_HUMAN (see all proteins):
    PPP2R5C    PPP2R5A    PPP2R5E    PPP2R5B

    PPP2R5D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPP2R5D
    PGOHUM00000233585


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/602 SNPs in PPP2R5D are shown (see all 602)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0694144
    ----see VAR_0694142 P S mis40--------
    rs559880471,2
    C--42950365(+) TTTTT-/TGAGAC 4 -- us2k10--------
    rs560444371,2
    --42950400(+) TCTGTC/TGCCCA 4 -- us2k10--------
    rs69011131,2
    C,A--42950639(+) attacA/Gggcgt 4 -- us2k10--------
    rs69012871,2
    C,F,A--42950746(+) aggctG/Agagcg 4 -- us2k13Minor allele frequency- A:0.33NA WA CSA 6
    rs69012891,2
    C,F--42950751(+) ggagcG/Acagtg 4 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs69238071,2
    C,F,A--42950800(+) tcaagT/Caattc 4 -- us2k17Minor allele frequency- C:0.19NA WA CSA EA 249
    rs1388399271,2
    C--42950822(+) CCTCCC/TACCGG 4 -- us2k10--------
    rs1492594381,2
    --42950878(+) CAGGCA/GCGCGC 4 -- us2k10--------
    rs1445187021,2
    C--42950883(+) GCGCGA/CCACCA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP2R5D (42952237 - 42980080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP2R5D:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv462930CNV Loss19166990
    nsv462929CNV Loss19166990
    nsv462927CNV Loss19166990
    nsv830651CNV Loss17160897


    Human Gene Mutation Database (HGMD): PPP2R5D
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R5D
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R5D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601646    OMIM disorders: --

    8 diseases for PPP2R5D:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    lissencephaly
    cerebritis    neuroblastoma    ovarian cancer    neuronitis


    PPP2R5D for disorders           About GeneDecksing


    Export disorders for PPP2R5D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP2R5D gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with PPP2R5D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A. (PubMed id 9180267)1, 2 Tanabe O.... Takeda M. (1997)
    5. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PubMed id 8703017)1, 2 McCright B.... Virshup D.M. (1996)
    6. Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A. (PubMed id 8566219)1, 2 Tanabe O.... Takeda M. (1996)
    7. Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)1, 3 McCright B. and Virshup D.M. (1995)
    8. Phosphorylation on the PPP2R5D B regulatory subunit m odulates the biochemical properties of protein phosphatase 2A. (PubMed id 20423611)1, 9 Yu U.Y. and Ahn J.H. (2010)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5528 HGNC: 9312 AceView: PPP2R5D Ensembl:ENSG00000112640 euGenes: HUgn5528
    ECgene: PPP2R5D Kegg: 5528 H-InvDB: PPP2R5D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP2R5D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R5D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP2R5D gene:
    Search GeneIP for patents involving PPP2R5D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PPP2R5D
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2R5D
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPP2R5D   OriGene RNAi products in human, mouse, rat for PPP2R5D  
     OriGene qPCR primer pairs and template standards for PPP2R5D   OriGene Protein Over-expression Lysate for PPP2R5D  
     OriGene MassSpec something-or-other for PPP2R5D   OriGene clones in human, mouse for PPP2R5D  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R5D   OriGene Purified Protein for PPP2R5D  
     OriGene ORF clones in mouse, rat for PPP2R5D   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP2R5D   OriGene Custom Protein Services for PPP2R5D  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP2R5D
     QIAGEN SeqTarget long-range PCR primers for resequencing PPP2R5D
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R5D
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2R5D
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R5D
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5D
     GenScript Custom Purified and Recombinant Proteins Services for PPP2R5D GenScript cDNA clones with any tag delivered in your preferred vector for PPP2R5D
     GenScript Custom Assay Services for PPP2R5D GenScript Custom Superior Antibodies Services for PPP2R5D
     GenScript Custom overexpressing Cell Line Services for PPP2R5D CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PPP2R5D 

     Regulatory tfbs in PPP2R5D promoter
     Search Chromatin IP Primers for PPP2R5D
     RT2 qPCR Primer Assay in human, mouse, rat PPP2R5D
     Search GNC Networks for PPP2R5D
     SABiosciences PCR Arrays including human, mouse, rat PPP2R5D
     Search Tocris compounds for PPP2R5D (2A5D)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PPP2R5D antibodies
     PPP2R5D proteins
     PPP2R5D lysates
     Antibodies for PPP2R5D
     See all of Abcam's Antibodies, Kits and Proteins for PPP2R5D
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PPP2R5D
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5D
     SwitchGear 3'UTR luciferase reporter plasmids for PPP2R5D
     SwitchGear Promoter luciferase reporter plasmids for PPP2R5D
     ThermoFisher Antibodies for PPP2R5D
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R5D
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP2R5D
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP2R5D
    Customized:
     lentivirus for stable overexpression of PPP2R5D
     lentivirus expression plasmids for stable overexpression of PPP2R5D
     adenovirus for overexpression of PPP2R5D
     LSBio Antibodies in human, mouse, rat for PPP2R5D
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP2R5D gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4