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PPP2R5D Gene

protein-coding   GIFtS: 63
GCID: GC06P042952

Protein Phosphatase 2, Regulatory Subunit B', Delta

(Previous names: protein phosphatase 2, regulatory subunit B (B56), delta...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit B', Delta1 2     B56D2
Protein Phosphatase 2, Regulatory Subunit B (B56), Delta Isoform1 2     PP2A, B Subunit, B' Delta Isoform2
Protein Phosphatase 2, Regulatory Subunit B', Delta Isoform1 2     PP2A, B Subunit, B56 Delta Isoform2
PP2A B Subunit Isoform B'-Delta2 3     PP2A, B Subunit, PR61 Delta Isoform2
PP2A B Subunit Isoform B56-Delta2 3     PP2A, B Subunit, R5 Delta Isoform2
PP2A B Subunit Isoform PR61-Delta2 3     Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Delta
Isoform2
PP2A B Subunit Isoform R5-Delta2 3     Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Delta
Isoform2

External Ids:    HGNC: 93121   Entrez Gene: 55282   Ensembl: ENSG000001126407   OMIM: 6016465   UniProtKB: Q147383   

Export aliases for PPP2R5D gene to outside databases

Previous GC identifers: GC06P042954 GC06P042999 GC06P043060 GC06P042669


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R5D Gene:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one
of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant
regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might
modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory
subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R5D Gene:
PPP2R5D (protein phosphatase 2, regulatory subunit B', delta) is a protein-coding gene. Diseases associated with PPP2R5D include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5B.

UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Wiki entry for PPP2R5D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R5D gene promoter:
         E2F-4   E2F-3a   STAT1   E2F-5   E2F-2   Evi-1   Egr-2   E2F   E2F-1   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2R5D promoter sequence
   Search Chromatin IP Primers for PPP2R5D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

PPP2R5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5D gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042952:  view genomic region     (about GC identifiers)

Start:
42,952,237 bp from pter      End:
42,980,080 bp from pter
Size:
27,844 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform  
Size: 602 amino acids; 69992 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Interacts with SGOL1
Secondary accessions: A8K3I9 B5BUA6 O00494 O00696 Q15171 Q5TC39
Alternative splicing: 3 isoforms:  Q14738-1   Q14738-2   Q14738-3   

Explore the universe of human proteins at neXtProt for PPP2R5D: NX_Q14738

Explore proteomics data for PPP2R5D at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys367, Lys409, Lys508, Lys548, Lys583
  • Modification sites at PhosphoSitePlus

  • See PPP2R5D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257405.1  NP_006236.1  NP_851307.1  NP_851308.1  

    ENSEMBL proteins: 
     ENSP00000417963   ENSP00000377669   ENSP00000420550   ENSP00000230402   ENSP00000420674  
     ENSP00000419756   ENSP00000420529  
    Reactome Protein details: Q14738

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    2 InterPro protein domains:
     IPR002554 PP2A_B56
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q14738

    ProtoNet protein and cluster: Q14738

    1 Blocks protein domain: IPB002554 Protein phosphatase 2A

    UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738
    Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family


    PPP2R5D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2A5D_HUMAN, Q14738
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment
    Induction: By retinoic acid; in neuroblastoma cell lines

         Genatlas biochemistry entry for PPP2R5D:
    protein phosphatase 2A,regulatory subunit B56 delta isoform,expressed in adult brain,cytosolic subunit of PPPR2A
    in interphase cells,concentrated in the nucleus of mitotic and recently divided cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity TAS--
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
    GO:0008601protein phosphatase type 2A regulator activity IEA--
         
    PPP2R5D for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPP2R5D:
     Decreased focal adhesion (FA)   Decreased number of cells in m  Decreased viability of wild-ty 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ppp2r5d):
     behavior/neurological  integument  mortality/aging  nervous system 

    PPP2R5D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp2r5dtm1Vjan for PPP2R5D

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R5D

    miRNA
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    miRTarBase miRNAs that target PPP2R5D:
    hsa-mir-1914-5p (MIRT035781), hsa-mir-615-3p (MIRT040037)

    Block miRNA regulation of human, mouse, rat PPP2R5D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R5D (see all 26):
    hsa-miR-148b* hsa-miR-1321 hsa-miR-328 hsa-miR-1205 hsa-miR-3605-5p hsa-miR-9 hsa-miR-4274 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5D 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R5D

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    2A5D_HUMAN, Q14738: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex IEA--
    GO:0005634nucleus TAS8703017
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    PPP2R5D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R5D About   (see all 44)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    DARPP-32 events0.32
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    ERKs are inactivated0.00
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R5D (see all 9)
        Telomerase Components in Cell Signaling
    TGF-Beta Pathway
    mTOR Pathway
    p70S6K Signaling
    ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for PPP2R5D
        Phosphatases

    4 GeneGo (Thomson Reuters) Pathways for PPP2R5D
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PPP2R5D (see all 8)
        Glycogen Metabolism
    IL-6 Signaling Pathway
    Aurora A signaling
    IL2-mediated signaling events
    Lissencephaly gene (LIS1) in neuronal migration and development

    Selected Reactome Pathways for PPP2R5D (see all 14)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Degradation of beta-catenin by the destruction complex
    Integration of energy metabolism
    Glycolysis


    5 Kegg Pathways  (Kegg details for PPP2R5D):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Dopaminergic synapse


    PPP2R5D for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R5D
    Interactions:

        Search GeneGlobe Interaction Network for PPP2R5D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R5D (Q147381, 2, 3 ENSP000004179634) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1BP301541, 3, ENSP000003113444EBI-396563,EBI-357094 I2D: score=3 STRING: ENSP00000311344
    PPP2R1AP301531, 3, ENSP000003248044EBI-396563,EBI-302388 I2D: score=2 STRING: ENSP00000324804
    SGOL2Q562F62, 3, ENSP000003504474MINT-8212557 I2D: score=2 STRING: ENSP00000350447
    PPFIA1Q131361, 2, 3, ENSP000002539254EBI-396563,EBI-745426 MINT-66659 I2D: score=6 STRING: ENSP00000253925
    SGOL1Q5FBB72, 3, ENSP000002637534MINT-8295766 I2D: score=3 STRING: ENSP00000263753
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--

    PPP2R5D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP2R5D (2A5D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R5D gene (4 alternative transcripts): 
    NM_001270476.1  NM_006245.3  NM_180976.2  NM_180977.2  

    Unigene Cluster for PPP2R5D:

    Protein phosphatase 2, regulatory subunit B', delta
    Hs.533308  [show with all ESTs]
    Unigene Representative Sequence: NM_001270476
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485511(uc003oth.3 uc011dva.2 uc003otj.3) ENST00000394110(uc021yzq.1 uc010jyd.3)
    ENST00000472118 ENST00000230402(uc003oti.3) ENST00000461010 ENST00000470467
    ENST00000467447 ENST00000482315 ENST00000486843
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate PPP2R5D (see all 26):
    hsa-miR-148b* hsa-miR-1321 hsa-miR-328 hsa-miR-1205 hsa-miR-3605-5p hsa-miR-9 hsa-miR-4274 hsa-miR-133a
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5D
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R5D

    Additional mRNA sequence: 

    AB000634.1 AB000635.1 AB209861.1 AB451342.1 AB451357.1 AK122701.1 AK290604.1 AK291797.1 
    AK299696.1 BC001095.2 BC001175.1 BC010692.1 D78360.1 L76702.1 

    20 DOTS entries:

    DT.100677856  DT.101976805  DT.40124305  DT.95272009  DT.100816629  DT.100816626  DT.92454606  DT.100816630 
    DT.121385635  DT.95272008  DT.100816627  DT.92454595  DT.100816631  DT.100816632  DT.121385651  DT.121385661 
    DT.99945016  DT.100816633  DT.121385662  DT.97854895 

    Selected AceView cDNA sequences (see all 971):

    BC001789 BE775102 BM804105 BP371234 AI050914 BX424626 BQ644624 AL602997 
    CD244269 CR625285 BE466726 AB000634 BE301653 CA439656 BU846070 BU185210 
    AL565370 BU685281 AL047473 AU120454 BM972160 BE270075 CR612447 AW296542 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5D (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a ·
    SP1:                                      -                                                                             -                                       
    SP2:                                -     -     -     -     -     -                                                     -                                       
    SP3:                                      -                 -     -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                      -     -                                                                                                               

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PPP2R5D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R5D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAGGTGGG
    PPP2R5D Expression
    About this image

    PPP2R5D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R5D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533308

    UniProtKB/Swiss-Prot: 2A5D_HUMAN, Q14738
    Tissue specificity: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R5D gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r5d1 , 5 protein phosphatase 2, regulatory subunit B (B56), more5
    protein phosphatase 2, regulatory subunit B', delta1
    90.24(n)1
    96.63(a)1
      17 (22.90 cM)5
    217701  NM_009358.31  NP_033384.21 
     466829915 
    chicken
    (Gallus gallus)
    Aves PPP2R5D1 protein phosphatase 2, regulatory subunit B', delta 80.17(n)
    92.65(a)
      421250  XM_419321.4  XP_419321.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R5D6
    protein phosphatase 2, regulatory subunit B', delt...
    90(a)
    1 ↔ 1
    2(144796668-144850743)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc41e122 Danio rerio cDNA clone MGC73160 IMAGE4144870, complete more 83.47(n)    BC064705.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PP2A-B'1 , 3 protein amino acid dephosphorylation
    protein phosphatase more3
    PP2A-B'1
    75(a)
    (best of 2)3
    66.36(n)1
    70.19(a)1
      90F13
    421691  NM_001275766.11  NP_001262695.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C13G3.3b3
    pptr-21
    pptr-21 65(a)
    (best of 3)3
    61.55(n)1
    68.18(a)1
      V(11030109-11031978)3
    1795261  NM_001129373.21  NP_001122845.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS16
    B-type regulatory subunit of protein phosphatase 2...
    37(a)
    1 → many
    XV(357674-359947) YOR014W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATB' DELTA1 ATB' DELTA 55.15(n)
    52.17(a)
      822200  NM_113507.2  NP_189232.1 
    rice
    (Oryza sativa)
    Liliopsida AK101208.12   -- 74.55(n)    AK101208.1 


    ENSEMBL Gene Tree for PPP2R5D (if available)
    TreeFam Gene Tree for PPP2R5D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R5D gene
    PPP2R5B2  PPP2R5A2  PPP2R5C2  PPP2R5E2  
    4 SIMAP similar genes for PPP2R5D using alignment to 5 protein entries:     2A5D_HUMAN (see all proteins):
    PPP2R5C    PPP2R5A    PPP2R5E    PPP2R5B

    PPP2R5D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPP2R5D
    PGOHUM00000233585


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R5D (see all 602)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559880471,2
    C--42950365(+) TTTTT-/TGAGAC 4 -- us2k10--------
    rs560444371,2
    --42950400(+) TCTGTC/TGCCCA 4 -- us2k10--------
    rs69011131,2
    C,A--42950639(+) attacA/Gggcgt 4 -- us2k10--------
    rs69012871,2
    C,F,A--42950746(+) aggctG/Agagcg 4 -- us2k13Minor allele frequency- A:0.33NA WA CSA 6
    rs69012891,2
    C,F--42950751(+) ggagcG/Acagtg 4 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs69238071,2
    C,F,A--42950800(+) tcaagT/Caattc 4 -- us2k17Minor allele frequency- C:0.19NA WA CSA EA 249
    rs1388399271,2
    C--42950822(+) CCTCCC/TACCGG 4 -- us2k10--------
    rs1492594381,2
    --42950878(+) CAGGCA/GCGCGC 4 -- us2k10--------
    rs1445187021,2
    C--42950883(+) GCGCGA/CCACCA 4 -- us2k10--------
    rs1846972351,2
    --42950894(+) CGCCCC/TGCTAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP2R5D (42952237 - 42980080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP2R5D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462930CNV Loss19166990
    nsv462929CNV Loss19166990
    nsv462927CNV Loss19166990
    nsv830651CNV Loss17160897

    Human Gene Mutation Database (HGMD): PPP2R5D
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R5D
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601646    OMIM disorders: --

    12 diseases for PPP2R5D:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    lissencephaly
    brain cancer    cerebritis    intellectual disability    malignant glioma
    hiv-1    neuroblastoma    ovarian cancer    neuronitis


    PPP2R5D for disorders           About GeneDecksing


    Export disorders for PPP2R5D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R5D gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with PPP2R5D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A. (PubMed id 9180267)1, 2 Tanabe O.... Takeda M. (FEBS Lett. 1997)
    5. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PubMed id 8703017)1, 2 McCright B.... Virshup D.M. (J. Biol. Chem. 1996)
    6. Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A. (PubMed id 8566219)1, 2 Tanabe O.... Takeda M. (FEBS Lett. 1996)
    7. Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)1, 3 McCright B. and Virshup D.M. (J. Biol. Chem. 1995)
    8. Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A. (PubMed id 20423611)1, 9 Yu U.Y. and Ahn J.H. (BMB Rep 2010)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5528 HGNC: 9312 AceView: PPP2R5D Ensembl:ENSG00000112640 euGenes: HUgn5528
    ECgene: PPP2R5D Kegg: 5528 H-InvDB: PPP2R5D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R5D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R5D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R5D gene:
    Search GeneIP for patents involving PPP2R5D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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