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PPP2R5C Gene

protein-coding   GIFtS: 67
GCID: GC14P102228

Protein Phosphatase 2, Regulatory Subunit B', Gamma

(Previous names: protein phosphatase 2, regulatory subunit B (B56), gamma...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit B', Gamma1 2     PP2A B Subunit Isoform R5-Gamma2 3
Protein Phosphatase 2, Regulatory Subunit B (B56), Gamma Isoform1 2     B56G2
Protein Phosphatase 2, Regulatory Subunit B', Gamma Isoform1 2     PR61G2
Renal Carcinoma Antigen NY-REN-292 3     B' Alpha Regulatory Subunit2
PP2A B Subunit Isoform B'-Gamma2 3     Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Gamma
Isoform2
PP2A B Subunit Isoform B56-Gamma2 3     KIAA00443
PP2A B Subunit Isoform PR61-Gamma2 3     

External Ids:    HGNC: 93111   Entrez Gene: 55272   Ensembl: ENSG000000783047   OMIM: 6016455   UniProtKB: Q133623   

Export aliases for PPP2R5C gene to outside databases

Previous GC identifers: GC14P099667 GC14P096091 GC14P100219 GC14P100266 GC14P101345 GC14P101298 GC14P082408


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R5C Gene:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one
of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant
regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might
modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory
subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R5C Gene:
PPP2R5C (protein phosphatase 2, regulatory subunit B', gamma) is a protein-coding gene. Diseases associated with PPP2R5C include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5D.

UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C
holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of
cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Gene Wiki entry for PPP2R5C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R5C gene promoter:
         LHX3b/Lhx3b   NRSF form 1   LUN-1   RelA   NRSF form 2   POU2F1   POU2F1a   LHX3a/Lhx3a   Chx10   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2R5C promoter sequence
   Search Chromatin IP Primers for PPP2R5C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.31

PPP2R5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5C gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P102228:  view genomic region     (about GC identifiers)

Start:
102,228,135 bp from pter      End:
102,394,329 bp from pter
Size:
166,195 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform  
Size: 524 amino acids; 61061 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit
(subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety
of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits
B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit,
viral proteins, and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct.
Interacts with SGOL1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at
Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts
with IER3 and/or ERK kinases; regulates ERK dephosphorylation
Sequence caution: Sequence=AAC50387.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG63760.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6 PDB 3D structures from and Proteopedia for PPP2R5C:
2IAE (3D)        2JAK (3D)        2NPP (3D)        2NYL (3D)        2NYM (3D)        3FGA (3D)    
Secondary accessions: B4DYJ8 B5BUA5 F5GWP3 Q14391 Q15060 Q15174 Q6ZN33
Alternative splicing: 5 isoforms:  Q13362-1   Q13362-2   Q13362-3   Q13362-4   Q13362-5   (Ref.3 (BAG63760) sequence is in conflict in position: 3:N->K. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R5C: NX_Q13362

Explore proteomics data for PPP2R5C at MOPED

Post-translational modifications: 

  • Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent
    and inhibits ERK dephosphorylation by PP2A-PPP2R5C1
  • Ubiquitination2 at Lys333
  • Modification sites at PhosphoSitePlus

  • See PPP2R5C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001155197.1  NP_001155198.1  NP_002710.2  NP_848701.1  NP_848702.1  

    ENSEMBL proteins: 
     ENSP00000450525   ENSP00000454035   ENSP00000329009   ENSP00000450931   ENSP00000452632  
     ENSP00000453875   ENSP00000262239   ENSP00000450867   ENSP00000454124   ENSP00000452500  
     ENSP00000452630   ENSP00000408389   ENSP00000333905   ENSP00000451179   ENSP00000450743  
     ENSP00000452533   ENSP00000452124   ENSP00000453906   ENSP00000450816   ENSP00000450626  
     ENSP00000412324  
    Reactome Protein details: Q13362

    PPP2R5C Human Recombinant Protein Products:

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    Novus Biologicals PPP2R5C Proteins
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    Cloud-Clone Corp. Proteins for PPP2R5C

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    2 InterPro protein domains:
     IPR002554 PP2A_B56
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q13362

    ProtoNet protein and cluster: Q13362

    1 Blocks protein domain: IPB002554 Protein phosphatase 2A

    UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362
    Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family


    PPP2R5C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2A5G_HUMAN, Q13362
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C
    holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of
    cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation
    Induction: Up-regulated upon DNA damage

         Genatlas biochemistry entry for PPP2R5C:
    protein phosphatase 2A,regulatory subunit B56 gamma isoform,expressed in cardiac and skeletal muscle

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI1328865
    GO:0008233peptidase activity ----
    GO:0008601protein phosphatase type 2A regulator activity NAS8703017
         
    PPP2R5C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP2R5C:
     Increased Erk phosphorylation   Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R5C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R5C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R5C

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP2R5C:
    hsa-mir-31-3p (MIRT038933), hsa-mir-30a-5p (MIRT028561), hsa-mir-16-5p (MIRT001428)

    Block miRNA regulation of human, mouse, rat PPP2R5C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R5C (see all 58):
    hsa-miR-193a-3p hsa-miR-429 hsa-miR-24-1* hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5C 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R5C

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PPP2R5C (NM_178587)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    2A5G_HUMAN, Q13362: Nucleus. Chromosome, centromere
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex NAS8703017
    GO:0000775chromosome, centromeric region IDA16580887
    GO:0005634nucleus IDA8703017
    GO:0016021integral component of membrane ----

    PPP2R5C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R5C About   (see all 39)  
    See pathways by source

    SuperPathContained pathways About
    1CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    CTLA4 inhibitory signaling0.32
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    5Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R5C (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    4 GeneGo (Thomson Reuters) Pathways for PPP2R5C
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5 BioSystems Pathways for PPP2R5C
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Glycogen Metabolism
    IL-6 Signaling Pathway

    Selected Reactome Pathways for PPP2R5C (see all 8)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    CTLA4 inhibitory signaling


    5 Kegg Pathways  (Kegg details for PPP2R5C):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Dopaminergic synapse


    PPP2R5C for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R5C
    Interactions:

        Search GeneGlobe Interaction Network for PPP2R5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R5C (Q133621, 2, 3 ENSP000003339054) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235030P466951, 2, 3, ENSP000004122834EBI-1266156,EBI-1748945 MINT-2835469 MINT-2835420 I2D: score=1 STRING: ENSP00000412283
    ENSG00000237155P466951, 2, 3, ENSP000003979564EBI-1266156,EBI-1748945 MINT-2835469 MINT-2835420 I2D: score=1 STRING: ENSP00000397956
    ENSG00000206478P466951, 2, 3EBI-1266156,EBI-1748945 MINT-2835469 MINT-2835420 I2D: score=1 
    ENSG00000227231P466951, 2, 3EBI-1266156,EBI-1748945 MINT-2835469 MINT-2835420 I2D: score=1 
    ENSG00000230128P466951, 2, 3EBI-1266156,EBI-1748945 MINT-2835469 MINT-2835420 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA17245430
    GO:0007165signal transduction NAS8703017
    GO:0008285negative regulation of cell proliferation IDA17245430
    GO:0016485protein processing ----
    GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP17245430

    PPP2R5C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP2R5C (2A5G)

    2 DrugBank Compounds for PPP2R5C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-- --target--10592235
    2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R5C gene (6 alternative transcripts): 
    NM_001161725.1  NM_001161726.1  NM_002719.3  NM_178586.2  NM_178587.2  NM_178588.1  

    Unigene Cluster for PPP2R5C:

    Protein phosphatase 2, regulatory subunit B', gamma
    Hs.368264  [show with all ESTs]
    Unigene Representative Sequence: NM_001161725
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000556068 ENST00000554442(uc001ykj.4) ENST00000556260 ENST00000328724
    ENST00000557268 ENST00000554504 ENST00000553890 ENST00000553554 ENST00000556086
    ENST00000350249 ENST00000557621 ENST00000556946 ENST00000556307 ENST00000553730(uc010txs.1)
    ENST00000557714 ENST00000445439(uc001ykn.3 uc001ykq.3) ENST00000334743
    ENST00000557095(uc010txt.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPP2R5C (see all 58):
    hsa-miR-193a-3p hsa-miR-429 hsa-miR-24-1* hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-183*
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R5C
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5C
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R5C

    Additional mRNA sequence: 

    AB451341.1 AK131391.1 AK302470.1 AK315072.1 BC016183.1 BC051442.1 BX248254.1 D26445.1 
    L42375.1 U37352.1 XR_132753.1 XR_159241.1 XR_172065.1 Z69030.1 

    Selected DOTS entries (see all 40):

    DT.100863853  DT.101984311  DT.454192  DT.97805144  DT.100769407  DT.100863841  DT.87016499  DT.100863843 
    DT.435301  DT.75157133  DT.120767618  DT.92450973  DT.101960478  DT.120767608  DT.75184036  DT.100863856 
    DT.120767551  DT.120856983  DT.95360518  DT.419692  DT.100715891  DT.120767625  DT.95360536  DT.120767537 

    Selected AceView cDNA sequences (see all 625):

    BQ433799 AI383105 BQ225716 AA625824 BQ051181 NM_178586 BC051442 BX413999 
    BM127332 AW955624 CR620797 AW105123 AA506292 BQ224425 BM711261 CB121251 
    BM561688 AA235395 NM_002719 CB128353 BX115515 AI364719 BM847224 BM841821 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5C (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                    -     -     -     -     -     -     -     -     -                                         -                                             
    SP2:                                                                                                                                                            
    SP3:              -     -     -     -     -     -     -     -     -     -                                                                                       
    SP4:                                                                                                                                                        -   
    SP5:                                                        -     -     -                                                                                       

    ExUns: 18a · 18b ^ 19a · 19b · 19c
    SP1:                              
    SP2:  -                           
    SP3:                              
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for PPP2R5C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPP2R5C Expression
    About this image


    PPP2R5C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
     
     Colon (Gastrointestinal Tract)
     
     Thyroid (Endocrine System)
    PPP2R5C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R5C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368264

    UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362
    Tissue specificity: Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and
    placenta. Very low levels in liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R5C gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r5c5 protein phosphatase 2, regulatory subunit B (B56), more   --   12 (60.56 cM) 110485739 
    chicken
    (Gallus gallus)
    Aves PPP2R5C6
    Gallus gallus protein phosphatase 2, regulatory su...
    90(a)
    1 ↔ 1
    5(49283997-49330671)
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R5C6
    protein phosphatase 2, regulatory subunit B', gamm...
    85(a)
    1 ↔ 1
    GL343232.1(2018227-2109681)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.111522 Xenopus laevis, Similar to protein phosphatase 2, regulatory more 79.72(n)    BC045057.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp2r5cb6
    protein phosphatase 2, regulatory subunit B', gamm...
    80(a)
    1 ↔ 1
    20(54253344-54318666) ENSDARG00000031200
    fruit fly
    (Drosophila melanogaster)
    Insecta PP2A-B'3 protein amino acid dephosphorylation
    protein phosphatase more
    79(a)
    (best of 2)
      90F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea W08G11.43 RTS1 PROTEIN (SCS1 PROTEIN) 66(a)
    (best of 3)
      V(16360199-16362996)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS1(YOR014W)4 B-type regulatory subunit of protein phosphatase 2A more   --   15(357674-359947) 854179  NP_014657.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G255101 AT5G25510 54.87(n)
    49.89(a)
      832626  NM_122462.1  NP_197933.1 
    rice
    (Oryza sativa)
    Liliopsida Os.274522 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.66(n)    AK067159.1 


    ENSEMBL Gene Tree for PPP2R5C (if available)
    TreeFam Gene Tree for PPP2R5C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R5C gene
    PPP2R5D2  PPP2R5B2  PPP2R5A2  PPP2R5E2  
    Selected SIMAP similar genes for PPP2R5C using alignment to 17 protein entries:     2A5G_HUMAN (see all proteins) (see all similar genes):
    PPP2R5D    TUBA1C    PPP2R5E    PFKFB3    PPP2R5B    PPP2R5A
    ABI2    ARL6IP5    ATF1    RQCD1    CDK10    NLN
    FLJ00047    NOSTRIN    SEPSECS    MST132    NELFA    EEF1E1

    PPP2R5C for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PPP2R5C
    PGOHUM00000262046 PGOHUM00000238038 PGOHUM00000232714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R5C (see all 2976)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996371281,2
    --102226193(+) AAATA-/GTTGTTGA 2 -- cds10--------
    rs1512214211,2
    C--102226194(+) AATAG-/TTGT  
            
    TTGAG
    2 -- us2k10--------
    rs2002123351,2
    C--102226197(+) AGTTG-/TTTG  
            
    AGACT
    2 -- us2k10--------
    rs785027961,2
    C,F--102226231(+) GTCTAA/CGAGCC 2 -- us2k12Minor allele frequency- C:0.05CSA WA 120
    rs1458334711,2
    --102226242(+) GGCAGA/GCATTC 2 -- us2k10--------
    rs1153920231,2
    C,F--102226375(+) CTTTGC/TCTGGA 2 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1845791381,2
    --102226440(+) CCAGTC/TAAGAT 2 -- us2k10--------
    rs1384790701,2
    --102226508(+) CGCTCC/TTAGAG 2 -- us2k10--------
    rs1884265821,2
    --102226641(+) CCTCTC/TCTCAC 2 -- us2k10--------
    rs1492319491,2
    --102226649(+) CACAGC/TTATTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP2R5C (102228135 - 102394329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PPP2R5C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656703CNV Deletion23128226
    esv2749146CNV Deletion23290073
    esv2749147CNV Deletion23290073
    esv2565595CNV Insertion19546169
    nsv512375CNV Loss21212237
    nsv902254CNV Loss21882294
    nsv902251CNV Loss21882294
    nsv84885CNV Loss16902084
    nsv518045CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R5C
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R5C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601645    OMIM disorders: --

    11 diseases for PPP2R5C:    
    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    cerebritis
    brain cancer    renal cell carcinoma    hiv-1    lung cancer
    leukemia    breast cancer    neuronitis


    PPP2R5C for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP2R5C
    Human Genome Epidemiology (HuGE) Navigator: PPP2R5C (3 documents)

    Export disorders for PPP2R5C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R5C gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with PPP2R5C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)1, 2, 3 McCright B. and Virshup D.M. (J. Biol. Chem. 1995)
    2. A genome-wide scan for common alleles affecting risk for autism. (PubMed id 20663923)1, 4 Anney R....Hallmayer J. (Hum. Mol. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. (PubMed id 17967874)1, 2 Shouse G.P.... Liu X. (Mol. Cell. Biol. 2008)
    5. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)1, 2 Li H.H.... Liu X. (EMBO J. 2007)
    6. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)
    7. Structure of the protein phosphatase 2A holoenzyme. (PubMed id 17174897)1, 2 Xu Y.... Shi Y. (Cell 2006)
    8. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (PubMed id 16580887)1, 2 Tang Z.... Yu H. (Dev. Cell 2006)
    9. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. (PubMed id 16456541)1, 2 Letourneux C.... Porteu F. (EMBO J. 2006)
    10. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5527 HGNC: 9311 AceView: PPP2R5C Ensembl:ENSG00000078304 euGenes: HUgn5527
    ECgene: PPP2R5C Kegg: 5527 H-InvDB: PPP2R5C

    (According to HUGE)
    About This Section

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    HUGE: KIAA0044

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP2R5C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP2R5C gene:
    Search GeneIP for patents involving PPP2R5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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