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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPP2R5C Gene

protein-coding GIFtS: 64
GCID: GC14P102228

protein phosphatase 2, regulatory subunit B', gamma

(Previous names: protein phosphatase 2, regulatory subunit B (B56), gamma...)

Explore 13 diseases affiliated with
PPP2R5C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Phosphatase 2, Regulatory Subunit B', Gamma¹ ²		PP2A B Subunit Isoform B56-Gamma² ³
B56G¹ ²		PP2A B Subunit Isoform PR61-Gamma² ³
PR61G¹ ²		PP2A B Subunit Isoform R5-Gamma² ³
Protein Phosphatase 2, Regulatory Subunit B (B56), Gamma Isoform¹ ²		B' Alpha Regulatory Subunit²
Protein Phosphatase 2, Regulatory Subunit B', Gamma Isoform¹ ²		Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Gamma Isoform²
Renal Carcinoma Antigen NY-REN-29² ³		KIAA0044³
PP2A B Subunit Isoform B'-Gamma² ³

External Ids:	HGNC: 9311¹	Entrez Gene: 5527²	Ensembl: ENSG00000078304⁷	OMIM: 601645⁵	UniProtKB: Q13362³

Export aliases for PPP2R5C gene to outside databases

Previous GC identifers: GC14P099667 GC14P096091 GC14P100219 GC14P100266 GC14P101345 GC14P101298 GC14P082408

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R5C:

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of

the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It

consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory

subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate

selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily.

Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct

the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may

specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation.

PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Gene Wiki entry for PPP2R5C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPP2R5C gene promoter:
LHX3b/Lhx3b NRSF form 1 LUN-1 RelA NRSF form 2 POU2F1 POU2F1a LHX3a/Lhx3a Chx10 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPP2R5C promoter sequence

Search SABiosciences Chromatin IP Primers for PPP2R5C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R5C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.31

PPP2R5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5C gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P102228: view genomic region (about GC identifiers)

Start:	102,228,135 bp from pter	End:	102,394,329 bp from pter
Size:	166,195 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Size: 524 amino acids; 61061 Da

Subunit: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C)

and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory

subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the

R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins,

and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct. Interacts with SGOL1; the

interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon

DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts with IER3 and/or ERK kinases;

regulates ERK dephosphorylation

Subcellular location: Nucleus. Chromosome, centromere

Sequence caution: Sequence=AAC50387.1; Type=Erroneous initiation;

6 PDB 3D structures from and Proteopedia for PPP2R5C:

2IAE (3D)

2JAK (3D)

2NPP (3D)

2NYL (3D)

2NYM (3D)

3FGA (3D)

Secondary accessions: B5BUA5 Q14391 Q15060 Q15174 Q6ZN33

Alternative splicing: 4 isoforms: Q13362-1 Q13362-2 Q13362-3 Q13362-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R5C: NX_Q13362

Post-translational modifications:

Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and

inhibits ERK dephosphorylation by PP2A-PPP2R5C¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13362

PPP2R5C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001155197.1 NP_001155198.1 NP_002710.2 NP_848701.1 NP_848702.1

ENSEMBL proteins:

ENSP00000450525 ENSP00000454035 ENSP00000329009 ENSP00000450931 ENSP00000452632

ENSP00000453875 ENSP00000262239 ENSP00000450867 ENSP00000454124 ENSP00000452500

ENSP00000452630 ENSP00000408389 ENSP00000333905 ENSP00000451179 ENSP00000450743

ENSP00000452533 ENSP00000452124 ENSP00000453906 ENSP00000450816 ENSP00000450626

ENSP00000412324

Reactome Protein details: Q13362
Human Recombinant Protein Products:

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	Uscn Proteins for PPP2R5C

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000159	protein phosphatase type 2A complex	NAS	8703017
GO:0000775	chromosome, centromeric region	IDA	16580887
GO:0005634	nucleus	IDA	8703017
GO:0016021	integral to membrane	--	--

PPP2R5C for ontologies About GeneDecksing

PPP2R5C Antibody Products:

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Assay Products for PPP2R5C:

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	Uscn ELISAs and CLIAs for PPP2R5C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPP2R5C for domains About GeneDecksing

2 InterPro domains/families:

IPR002554 PP2A_B56

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q13362

ProtoNet protein and cluster: Q13362

1 Blocks protein family: IPB002554 Protein phosphatase 2A

UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362

Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct

the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may

specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation.

PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation

Induction: Up-regulated upon DNA damage

Genatlas biochemistry entry for PPP2R5C:

protein phosphatase 2A,regulatory subunit B56 gamma isoform,expressed in cardiac and skeletal muscle

miRNA Products:		miRTarBase miRNAs that target PPP2R5C: hsa-mir-16 (MIRT001428)

		OriGene 3'-UTR Clone (see all 5): PPP2R5C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP2R5C
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2R5C (see all 58):
		hsa-miR-193a-3p hsa-miR-429 hsa-miR-24-1* hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-183*

		SwitchGear 3'UTR luciferase reporter plasmid: PPP2R5C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP2R5C (see all 4) OriGene siRNA: PPP2R5C
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5C

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15380617
GO:0008233	peptidase activity	--	--
GO:0008601	protein phosphatase type 2A regulator activity	NAS	8703017

PPP2R5C for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PPP2R5C:

Increased Erk phosphorylation

Increased apoptosis

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Wnt Signaling Pathway

	Wnt Signaling Pathway	1.00			DNA damage response (only ATM dependent)	0.35
	Wnt Signaling Pathway and Pluripotency	0.55			Wnt signaling pathway	0.30

Platelet sensitization by LDL

	Platelet sensitization by LDL	1.00			CTLA4 inhibitory signaling	0.34
	Beta-catenin phosphorylation cascade	0.39

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

p70S6K Signaling

	p70S6K Signaling	1.00			mTOR Pathway	0.54
	Renin-Angiotensin Pathway	0.60

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for PPP2R5C

	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Signal transduction PKA signaling

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2R5C (see all 25)

	Cell Cycle Control by BTG Proteins
	Telomerase Components in Cell Signaling
	CDK5 Pathway
	mTOR Pathway
	Cyclins and Cell Cycle Regulation

4 GeneGo (Thomson Reuters) Pathways for PPP2R5C

	Signal transduction PKA signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

5 BioSystems Pathways for PPP2R5C

	DNA damage response (only ATM dependent)
	Glycogen Metabolism
	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway
	IL-6 Signaling Pathway

5/22 Reactome Pathways for PPP2R5C (see all 22)

	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Costimulation by the CD28 family
	Cell Cycle
	M Phase

3 Kegg Pathways (Kegg details for PPP2R5C):

	mRNA surveillance pathway
	Oocyte meiosis
	Wnt signaling pathway

PPP2R5C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PPP2R5C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for PPP2R5C (Q13362^{1, 2, 3} ENSP00000333905⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2R1A	P30153¹^,²^,³, ENSP00000324804⁴	EBI-1266170,EBI-302388 MINT-4299213 I2D: score=3 STRING: ENSP00000324804
PPP2R1B	P30154²^,³, ENSP00000311344⁴	MINT-2835624 I2D: score=5 STRING: ENSP00000311344
CHEK2	O96017¹^,³, ENSP00000372023⁴	EBI-1266176,EBI-1180783 I2D: score=1 STRING: ENSP00000372023
IER3	P46695²^,³	MINT-2835469 MINT-2835420 I2D: score=1
MAPK1	P28482²^,³, ENSP00000215832⁴	MINT-2835604 I2D: score=1 STRING: ENSP00000215832

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IDA	17245430
GO:0007165	signal transduction	NAS	8703017
GO:0008285	negative regulation of cell proliferation	IDA	17245430
GO:0016485	protein processing	--	--
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	17245430

PPP2R5C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PPP2R5C:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPP2R5C

2 DrugBank Compounds for PPP2R5C About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	--	--	target	--	10592235
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about PPP2R5C / 2A5G

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPP2R5C gene (6 alternative transcripts):

NM_001161725.1 NM_001161726.1 NM_002719.3 NM_178586.2 NM_178587.2 NM_178588.1

Unigene Cluster for PPP2R5C:

Protein phosphatase 2, regulatory subunit B', gamma

Hs.368264 [show with all ESTs]

Unigene Representative Sequence: NM_001161725

18/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):

ENST00000556068 ENST00000554442(uc001ykj.4) ENST00000556260 ENST00000328724

ENST00000557268 ENST00000554504 ENST00000553890 ENST00000553554 ENST00000556086

ENST00000350249 ENST00000557621 ENST00000556946 ENST00000556307 ENST00000553730(uc010txs.1)

ENST00000557714 ENST00000445439(uc001ykn.3 uc001ykq.3) ENST00000334743

ENST00000557095(uc010txt.2)

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		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2R5C (see all 58):
		hsa-miR-193a-3p hsa-miR-429 hsa-miR-24-1* hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-183*

		SwitchGear 3'UTR luciferase reporter plasmid: PPP2R5C 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R5C

Additional cDNA sequence:

AB451341.1 AK131391.1 AK302470.1 AK315072.1 BC016183.1 BC051442.1 BX248254.1 D26445.1

L42375.1 U37352.1 XR_132753.1 XR_159241.1 XR_172065.1 Z69030.1

24/40 DOTS entries (see all 40):

DT.100863853 DT.101984311 DT.454192 DT.97805144 DT.100769407 DT.100863841 DT.87016499 DT.100863843

DT.435301 DT.101960478 DT.120767618 DT.75157133 DT.92450973 DT.120767608 DT.75184036 DT.100863856

DT.120767551 DT.120856983 DT.419692 DT.100715891 DT.120767625 DT.95360518 DT.95360536 DT.100832040

24/625 AceView cDNA sequences (see all 625):

BU161947 BQ225716 D26445 AA381718 BX326202 AU076760 C05373 CA421086

BX248254 AW576344 BQ433799 AA905224 AA236880 AI015984 CA393817 BU175452

BG575830 CD514747 BX359512 BU161392 BQ006619 AV706057 AA663422 AI364720

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5C (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16	^	17	^
SP1:							-		-		-		-		-		-		-		-		-														-
SP2:
SP3:					-		-		-		-		-		-		-		-		-		-
SP4:																																																			-
SP5:																			-		-		-

ExUns:	18a	·	18b	^	19a	·	19b	·	19c
SP1:
SP2:	-
SP3:
SP4:	-
SP5:

ECgene alternative splicing isoforms for PPP2R5C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP2R5C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See PPP2R5C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP2R5C

SOURCE GeneReport for Unigene cluster: Hs.368264

UniProtKB/Swiss-Prot: 2A5G_HUMAN, Q13362

Tissue specificity: Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and

placenta. Very low levels in liver

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5C gene from 10/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ppp2r5c⁵	protein phosphatase 2, regulatory subunit B (B56), more	--		12 (60.56 cM) 110485739
chicken (Gallus gallus)	Aves	Q5F3C6_CHICK⁶	Uncharacterized protein	85(a)	1 ↔ 1	5(51849597-51925026)
lizard (Anolis carolinensis)	Reptilia	PPP2R5C⁶	--	93(a)	1 ↔ 1	GL343232.1(2018227-2041545)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11152²	Xenopus laevis, Similar to protein phosphatase 2, regulatory more	79.72(n)		BC045057.1
zebrafish (Danio rerio)	Actinopterygii	ppp2r5cb¹	protein phosphatase 2, regulatory subunit B', gamma more	75.11(n) 88.27(a)		557208 NM_001044821.2 NP_001038286.2
fruit fly (Drosophila melanogaster)	Insecta	PP2A-B'³	protein amino acid dephosphorylation protein phosphatase more	79(a) (best of 2)		90F1 --
worm (Caenorhabditis elegans)	Secernentea	W08G11.4³	RTS1 PROTEIN (SCS1 PROTEIN)	66(a) (best of 3)		V(16360199-16362996) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RTS1(YOR014W)⁴ RTS1¹	B-type regulatory subunit of protein phosphatase 2A more⁴ Rts1p¹	56.94(n)¹ 54.97(a)¹		15(357674-359947)⁴ 854179^{1, 4} NP_014657.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G13460¹	protein phosphatase 2 (formerly 2A), regulatory subunit more	56.31(n) 50.74(a)		837906 NM_101216.1 NP_172803.1
rice (Oryza sativa)	Liliopsida	Os.27452²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	72.66(n)		AK067159.1

ENSEMBL Gene Tree for PPP2R5C (if available)
TreeFam Gene Tree for PPP2R5C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPP2R5C gene

PPP2R5D² PPP2R5B² PPP2R5A² PPP2R5E²

18/25 SIMAP similar genes for PPP2R5C using alignment to 18 protein entries: 2A5G_HUMAN (see all proteins) (see all similar genes):

PPP2R5D TUBA1C PPP2R5E PFKFB3 PPP2R5B PPP2R5A

ABI2 ARL6IP5 ATF1 RQCD1 NCKAP1L CDK10

KIAA0101 NLN FLJ00047 NOSTRIN SEPSECS MST132

PPP2R5C for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for PPP2R5C
PGOHUM00000262046 PGOHUM00000238038 PGOHUM00000232714

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61994048^1,2		--	82469137(+)	`AATTCG/TGTACC`	1	--	us2k¹		1		NA	2
rs28630780^1,2		--	82470366(+)	`ACTCAC/TTAATA`	1	--	int¹		0	--	--	--	--
rs75313548^1,2		--	82470520(+)	`CAGTGT/GGTTAG`	1	--	int¹		1		WA	118
rs74937523^1,2	C,F,	--	82470661(+)	`CAAAAG/CGGTGT`	1	--	int¹		1		WA	118
rs111927759^1,2		--	82470831(+)	`TACAGG/AAGAAA`	1	--	int¹		1		CSA	1
rs112870849^1,2	C,	--	82471751(+)	`AGATAC/TTTTTC`	1	--	int¹		1		NA	2
rs73356833^1,2	C,	--	82472595(+)	`ATTTAG/ATATTC`	1	--	int¹		3		WA CSA	121
rs76629736^1,2		--	82473831(+)	`TTTTTT/GTATTC`	1	--	int¹		2		CSA WA	120
rs66877816^1,2	C,F,	--	82474677(+)	`CCTCAA/GAAACT`	1	--	int¹		8		NA WA CSA EA	366
rs74771753^1,2	F,	--	82475280(+)	`CATAAG/AGCTGG`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for PPP2R5C (102228135 - 102394329 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for PPP2R5C
4 CNVs: 87360 87358 76734 76733
12 Indels: 87362 87361 87363 87357 76732 76729 11771 76735 76730 102025 76731 87359

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPP2R5C for disorders           About GeneDecksing

OMIM gene information: 601645    OMIM disorders: --

13 diseases for PPP2R5C:    About MalaCards

renal carcinoma cerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3

adenomatous polyposis coli carcinoma renal cell carcinoma polyposis

cerebritis colon carcinoma lung cancer immunodeficiency

breast cancer

Human Genome Epidemiology (HuGE) Navigator: PPP2R5C (3 documents)

Export disorders for PPP2R5C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PPP2R5C gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with PPP2R5C)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)^{1, 2, 3} McCright B. and Virshup D.M. (1995)
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. (PubMed id 17967874)^{1, 2} Shouse G.P....Liu X. (2008)
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)^{1, 2} Li H.H.... Liu X. (2007)
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)^{1, 2} Kitajima T.S.... Watanabe Y. (2006)
Structure of the protein phosphatase 2A holoenzyme. (PubMed id 17174897)^{1, 2} Xu Y.... Shi Y. (2006)
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (PubMed id 16580887)^{1, 2} Tang Z....Yu H. (2006)
B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. (PubMed id 16456541)^{1, 2} Letourneux C....Porteu F. (2006)
Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2} Scanlan M.J....Old L.J. (1999)
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. (PubMed id 8617797)^{1, 2} Tehrani M.A.... Kamibayashi C. (1996)
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PubMed id 8703017)^{1, 2} McCright B.... Virshup D.M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5527	HGNC: 9311	AceView: PPP2R5C	Ensembl:ENSG00000078304	euGenes: HUgn5527
ECgene: PPP2R5C	Kegg: 5527	H-InvDB: PPP2R5C

(According to HUGE)
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HUGE: KIAA0044

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPP2R5C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PPP2R5C gene
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Patent Information for PPP2R5C gene:
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PPP2R5C Gene

protein phosphatase 2, regulatory subunit B', gamma

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PPP2R5C Gene

protein phosphatase 2, regulatory subunit B', gamma

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