Aliases for PPP2R5B Gene
Aliases for PPP2R5B Gene
- Protein Phosphatase 2 Regulatory Subunit B'Beta 2
- Protein Phosphatase 2 Regulatory Subunit Bbeta 2 3 5
- PP2A B Subunit Isoform PR61-Beta 3 4
- PP2A B Subunit Isoform B56-Beta 3 4
- PP2A B Subunit Isoform R5-Beta 3 4
- PP2A B Subunit Isoform B-Beta 3 4
- Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta Isoform 2
- Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Beta Isoform 3
- Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform 2
- Protein Phosphatase 2, Regulatory Subunit B, Beta Isoform 3
External Ids for PPP2R5B Gene
- HGNC: 9310
- Entrez Gene: 5526
- Ensembl: ENSG00000068971
- OMIM: 601644
- UniProtKB: Q15173
Previous GeneCards Identifiers for PPP2R5B Gene
- GC11P067208
- GC11P066373
- GC11P064942
- GC11P064468
- GC11P064469
- GC11P064448
- GC11P064692
- GC11P061019
Summaries for PPP2R5B Gene
-
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2R5B Gene
PPP2R5B (Protein Phosphatase 2 Regulatory Subunit B'Beta) is a Protein Coding gene. Diseases associated with PPP2R5B include Pancreatic Gastrinoma. Among its related pathways are CTLA4 Signaling and RET signaling. GO annotations related to this gene include binding. An important paralog of this gene is PPP2R5A.
UniProtKB/Swiss-Prot for PPP2R5B Gene
-
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5B Gene
Genomics for PPP2R5B Gene
Regulatory Elements for PPP2R5B Gene
Enhancers for PPP2R5B Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PPP2R5B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PPP2R5B gene promoter:
Regulatory Element Products
Genomic Location for PPP2R5B Gene
- Chromosome:
- 11
- Start:
- 64,917,553 bp from pter
- End:
- 64,934,478 bp from pter
- Size:
- 16,926 bases
- Orientation:
- Plus strand
Genomic View for PPP2R5B Gene
Genes around PPP2R5B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
PPP2R5B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP2R5B Gene
Proteins for PPP2R5B Gene
-
Protein details for PPP2R5B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15173-2A5B_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
- Protein Accession:
- Q15173
- Q13853
Protein attributes for PPP2R5B Gene
- Size:
- 497 amino acids
- Molecular mass:
- 57393 Da
- Quaternary structure:
-
- Component of the serine/threonine-protein phosphatase 2A complex (PP2A). This complex consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant scaffold subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (PubMed:23135275). Interacts with SGO1 (PubMed:16541025). Interacts with AKT1 (PubMed:21329884). Interacts with CUL3 and KLHL15; this interaction leads to proteasomal degradation (PubMed:23135275).
Protein Expression for PPP2R5B Gene
Post-translational modifications for PPP2R5B Gene
- Ubiquitinated by E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PPP2R5B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PPP2R5B
- Invitrogen Antibodies for PPP2R5B
- antibodies-online Antibodies for PPP2R5B: See all 25
- GeneTex PPP2R5B antibody for PPP2R5B
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R5B
Protein Products
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OriGene Purified Proteins for PPP2R5B
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2R5B
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- antibodies-online Proteins for PPP2R5B: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PPP2R5B
No data available for DME Specific Peptides for PPP2R5B Gene
Domains & Families for PPP2R5B Gene
Gene Families for PPP2R5B Gene
Protein Domains for PPP2R5B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP2R5B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15173- Family:
-
- Belongs to the phosphatase 2A regulatory subunit B56 family.
Function for PPP2R5B Gene
Molecular function for PPP2R5B Gene
- GENATLAS Biochemistry:
- protein phosphatase 2B,regulatory subunit B56 beta isoform,expressed in brain,with CAG repeat,excluded as a candidate gene for MEN1
- UniProtKB/Swiss-Prot Function:
- As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
- UniProtKB/Swiss-Prot Induction:
- By retinoic acid; in neuroblastoma cell lines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 7592815 |
| GO:0019888 | protein phosphatase regulator activity | IEA | -- |
Phenotypes for PPP2R5B Gene
- GenomeRNAi human phenotypes for PPP2R5B:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Decreased viability
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R5B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R5B gene
- Search ViGene Biosciences for PPP2R5B
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R5B
-
Applied Biological Materials CRISPR for PPP2R5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R5B
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PPP2R5B
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-
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Clone Products
-
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R5B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PPP2R5B
-
ViGene Biosciences adenoviral particle packaged cDNA for PPP2R5B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R5B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R5B gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPP2R5B Gene
Localization for PPP2R5B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | IEA | -- |
| GO:0005737 | cytoplasm | TAS | 8703017 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PPP2R5B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | S45 mutants of beta-catenin arent phosphorylated | ||
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Beta-Adrenergic Signaling |
.36
|
|
| 5 | p70S6K Signaling |
.60
|
.54
|
Pathways by source for PPP2R5B Gene
1 BioSystems pathway for PPP2R5B Gene
97 Reactome pathways for PPP2R5B Gene
7 KEGG pathways for PPP2R5B Gene
4 GeneGo (Thomson Reuters) pathways for PPP2R5B Gene
25 Qiagen pathways for PPP2R5B Gene
Interacting Proteins for PPP2R5B Gene
Selected Interacting proteins:
Q15173-2A5B_HUMAN
ENSP00000164133
for PPP2R5B Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0010469 | regulation of receptor activity | IEA | -- |
| GO:0010976 | positive regulation of neuron projection development | IEA | -- |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | TAS | -- |
Transcripts for PPP2R5B Gene
mRNA/cDNA for PPP2R5B Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (128) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPP2R5B Gene
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R5B
-
Applied Biological Materials CRISPR for PPP2R5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R5B
- GenScript: Design CRISPR guide RNA sequences for PPP2R5B
miRNA Products
- Search ViGene Biosciences for PPP2R5B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PPP2R5B
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-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R5B gene
Clone Products
-
OriGene ORF clones in human for PPP2R5B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PPP2R5B
- VectorBuilder custom plasmid, inducible vectors for PPP2R5B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R5B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for PPP2R5B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Fetal Brain (19.5), Plasma (18.6), and Spinal cord (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP2R5B Gene
NURSA nuclear receptor signaling pathways regulating expression of PPP2R5B Gene:
PPP2R5BSOURCE GeneReport for Unigene cluster for PPP2R5B Gene:
Hs.75199mRNA Expression by UniProt/SwissProt for PPP2R5B Gene:
Q15173-2A5B_HUMAN
Tissue specificity:
Highest expression in brain.
Evidence on tissue expression from TISSUES for PPP2R5B Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for PPP2R5B
-
OriGene qPCR primer pairs and template standards for PPP2R5B
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R5B Gene
Orthologs for PPP2R5B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP2R5B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PPP2R5B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PPP2R5B 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppp2r5b 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ppp2r5b 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp2r5b 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | PPP2R5B 35 |
|
OneToOne | |
| LOC562282 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | BcDNA:LD34343 36 |
|
|
|
| wdb 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | W08G11.4 36 |
|
|
|
| pptr-1 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RTS1 35 |
|
OneToMany | |
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10909 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany |
- Species where no ortholog for PPP2R5B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PPP2R5B Gene
Variants for PPP2R5B Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs747411292 | Uncertain significance | 64,927,887(+) | GCCTT(C/T)GTGGC | reference, missense | |
| rs1000041199 | -- | 64,918,129(+) | TTATA(C/T)ATAAC | intron-variant, upstream-variant-2KB | |
| rs1000147650 | -- | 64,924,223(+) | GCACT(A/G)ACTCA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000178618 | -- | 64,923,895(+) | ACTTT(G/T)GGTTA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000287192 | -- | 64,930,269(+) | AAGGG(G/T)GCACT | intron-variant |
Residual Variation Intolerance Score:
17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.56;
12.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PPP2R5B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5B Gene
Disorders for PPP2R5B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic gastrinoma |
|
|
Search PPP2R5B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PPP2R5B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PPP2R5B
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R5B Gene
Publications for PPP2R5B Gene
- Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B. … Virshup D.M. (J. Biol. Chem. 1995) 2 3 4 64
- Selective proteasomal degradation of the B'I^ subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. (PMID: 23135275) Oberg E.A. … Strack S. (J. Biol. Chem. 2012) 3 4 64
- Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima T.S. … Watanabe Y. (Nature 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). (PMID: 9272177) Forbes S.A. … Kas K. (Hum. Genet. 1997) 3 22 64
Products for PPP2R5B Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for PPP2R5B gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2R5B
- VectorBuilder custom plasmid, inducible vectors for PPP2R5B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R5B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PPP2R5B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
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