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PPP2R5B Gene

protein-coding   GIFtS: 61
GCID: GC11P064692

Protein Phosphatase 2, Regulatory Subunit B', Beta

(Previous names: protein phosphatase 2, regulatory subunit B (B56), beta...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit B', Beta1 2     B56 Beta Isoform1
Protein Phosphatase 2, Regulatory Subunit B', Beta Isoform1 2     Beta Isoform1
PP2A B Subunit Isoform B'-Beta2 3     PR61 Beta Isoform1
PP2A B Subunit Isoform B56-Beta2 3     Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform1
PP2A B Subunit Isoform PR61-Beta2 3     R5 Beta Isoform1
PP2A B Subunit Isoform R5-Beta2 3     Serine/Threonine Protein Phosphatase 2A1
56 KDa Regulatory Subunit1     B56B2
PP2A1     PR61B2
B Subunit1     Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta
Isoform2
B' Beta Isoform1     Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Beta
Isoform2

External Ids:    HGNC: 93101   Entrez Gene: 55262   Ensembl: ENSG000000689717   OMIM: 6016445   UniProtKB: Q151733   

Export aliases for PPP2R5B gene to outside databases

Previous GC identifers: GC11P067208 GC11P066373 GC11P064942 GC11P064468 GC11P064469 GC11P064448 GC11P061019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R5B Gene:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one
of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant
regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might
modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit
B56 subfamily. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R5B Gene:
PPP2R5B (protein phosphatase 2, regulatory subunit B', beta) is a protein-coding gene. Diseases associated with PPP2R5B include pancreatic gastrinoma, and cerebral cavernous malformations 3. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5D.

UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form
mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308'
and 'Ser-373' residues

Gene Wiki entry for PPP2R5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R5B gene promoter:
         Egr-3   TBP   NF-1   p53   Sp1   Ik-3   YY1   C/EBPalpha   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2R5B promoter sequence
   Search Chromatin IP Primers for PPP2R5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q12

PPP2R5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064692:  view genomic region     (about GC identifiers)

Start:
64,685,025 bp from pter      End:
64,701,950 bp from pter
Size:
16,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform  
Size: 497 amino acids; 57393 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Interacts with SGOL1. Interacts with AKT1
Secondary accessions: Q13853
Alternative splicing: 2 isoforms:  Q15173-1   Q15173-2   

Explore the universe of human proteins at neXtProt for PPP2R5B: NX_Q15173

Explore proteomics data for PPP2R5B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP2R5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006235.1  
    ENSEMBL proteins: 
     ENSP00000437088   ENSP00000164133   ENSP00000436136  
    Reactome Protein details: Q15173

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    2 InterPro protein domains:
     IPR002554 PP2A_B56
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q15173

    ProtoNet protein and cluster: Q15173

    1 Blocks protein domain: IPB002554 Protein phosphatase 2A

    UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173
    Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family


    PPP2R5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2A5B_HUMAN, Q15173
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form
    mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308'
    and 'Ser-373' residues
    Induction: By retinoic acid; in neuroblastoma cell lines

         Genatlas biochemistry entry for PPP2R5B:
    protein phosphatase 2B,regulatory subunit B56 beta isoform,expressed in brain,with CAG repeat,excluded as a
    candidate gene for MEN1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15380617
    GO:0008601protein phosphatase type 2A regulator activity IEA--
         
    PPP2R5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP2R5B:
     Decreased focal adhesion (FA)  

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    2A5B_HUMAN, Q15173: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex IEA--
    GO:0005737cytoplasm TAS8703017
    GO:0005829cytosol TAS--

    PPP2R5B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R5B About   (see all 40)  
    See pathways by source

    SuperPathContained pathways About
    1CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    CTLA4 inhibitory signaling0.32
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    5Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R5B (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    4 GeneGo (Thomson Reuters) Pathways for PPP2R5B
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    2 BioSystems Pathways for PPP2R5B
        Glycogen Metabolism
    IL-6 Signaling Pathway

    Selected Reactome Pathways for PPP2R5B (see all 9)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Degradation of beta-catenin by the destruction complex
    XBP1(S) activates chaperone genes
    Separation of Sister Chromatids


    5 Kegg Pathways  (Kegg details for PPP2R5B):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Dopaminergic synapse


    PPP2R5B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R5B
    Interactions:

        Search GeneGlobe Interaction Network for PPP2R5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R5B (Q151731, 2, 3 ENSP000001641334) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206478P466951, 2, 3EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    ENSG00000227231P466951, 2, 3EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    ENSG00000230128P466951, 2, 3EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    IER3P466951, 2, 3EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    ENSG00000235030P466951, 2, 3, ENSP000004122834EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 STRING: ENSP00000412283
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007165signal transduction ----
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--

    PPP2R5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for PPP2R5B (2A5B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R5B gene: 
    NM_006244.3  

    Unigene Cluster for PPP2R5B:

    Protein phosphatase 2, regulatory subunit B', beta
    Hs.75199  [show with all ESTs]
    Unigene Representative Sequence: NM_006244
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413292 ENST00000526559 ENST00000164133(uc001oby.3) ENST00000532850
    ENST00000528530
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK092730.1 BC045619.1 L42374.1 

    10 DOTS entries:

    DT.448055  DT.40115701  DT.102823186  DT.100755008  DT.95264992  DT.95264998  DT.100755007  DT.216640 
    DT.95136357  DT.95199134 

    Selected AceView cDNA sequences (see all 128):

    BM680916 BQ446332 AK092730 F11602 AA338665 AI471724 AI621363 BG056519 
    F12879 L42374 AI142483 R35256 BM665417 AW300636 F11874 CA842477 
    T33432 BQ716698 F09521 CD742806 T32092 CR621212 CA390311 BX094477 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTACTCCT
    PPP2R5B Expression
    About this image


    PPP2R5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Eye (Sensory Organs)
             Retina
    PPP2R5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75199

    UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173
    Tissue specificity: Highest expression in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R5B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r5b1 , 5 protein phosphatase 2, regulatory subunit B (B56), more5
    protein phosphatase 2, regulatory subunit B', beta1
    92.42(n)1
    98.79(a)1
      19 (4.35 cM)5
    2258491  NM_198168.31  NP_937811.11 
     62277655 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppp2r5b1 protein phosphatase 2, regulatory subunit B', beta 76.03(n)
    86.16(a)
      100101792  NM_001100279.1  NP_001093749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5622821 serine/threonine-protein phosphatase 2A 56 kDa regulatory more 76.32(n)
    83.09(a)
      562282  XM_685678.3  XP_690770.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD343433 protein serine/threonine phosphatase 75(a)   98A6   --
    worm
    (Caenorhabditis elegans)
    Secernentea W08G11.43 RTS1 PROTEIN (SCS1 PROTEIN) 64(a)   V(16360199-16362996)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS16
    B-type regulatory subunit of protein phosphatase 2...
    32(a)
    1 → many
    XV(357674-359947) YOR014W
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.109092 Vitis vinifera transcribed sequence with moderate similarity more 73.04(n)    CB006035.1 


    ENSEMBL Gene Tree for PPP2R5B (if available)
    TreeFam Gene Tree for PPP2R5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R5B gene
    PPP2R5D2  PPP2R5A2  PPP2R5C2  PPP2R5E2  
    4 SIMAP similar genes for PPP2R5B using alignment to 3 protein entries:     2A5B_HUMAN (see all proteins):
    PPP2R5A    PPP2R5E    PPP2R5C    PPP2R5D

    PPP2R5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R5B (see all 250)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389596511,2
    C--64690220(+) TGGGCA/GCCTGA 1 -- us2k10--------
    rs1842705181,2
    --64690225(+) GCCTGA/CAGTCC 1 -- us2k10--------
    rs6468521,2
    C,A,H--64690241(-) gcctcT/Ccgaat 1 -- us2k17Minor allele frequency- C:0.07NA CSA 14
    rs1890814861,2
    --64690274(+) CCCAGC/GAGGCG 1 -- us2k10--------
    rs1458803451,2
    --64690573(+) ATTACA/TGGTAT 1 -- us2k10--------
    rs1481767351,2
    --64690771(+) GCTTCG/TCCTCT 1 -- us2k10--------
    rs6163221,2
    C,F,A,H--64690875(-) TCTCCC/GTCCTT 1 -- us2k1 trp38Minor allele frequency- G:0.23MN NS EA NA 1014
    rs1506210871,2
    --64690920(+) GGGCCG/TGATGG 1 -- us2k10--------
    rs1387584451,2
    --64690981(+) AGTGCA/CGGAGT 1 -- us2k10--------
    rs768913501,2
    C,F--64690994(+) TGGACC/TCCAGC 1 -- us2k12Minor allele frequency- T:0.14WA 120

    HapMap Linkage Disequilibrium report for PPP2R5B (64685025 - 64701950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP2R5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1173n71CNV Loss21882294
    nsv528506CNV Loss19592680
    dgv1171n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R5B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601644    OMIM disorders: --

    17 diseases for PPP2R5B:    
    About MalaCards
    pancreatic gastrinoma    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    wermer syndrome    gastrinoma    multiple endocrine neoplasia    kaposi's sarcoma
    cerebritis    hiv-1    neuroblastoma    sarcoma
    pancreatitis    cervicitis    retinitis    breast cancer
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for PPP2R5B:
    Pancreatic gastrinoma     Wermer syndrome

    PPP2R5B for disorders           About GeneDecksing


    Export disorders for PPP2R5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R5B gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PPP2R5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)1, 2, 3 McCright B. and Virshup D.M. (J. Biol. Chem. 1995)
    2. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PubMed id 8694763)1, 2 Zolnierowicz S.... Hemmings B.A. (Biochem. J. 1996)
    5. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PubMed id 8703017)1, 2 McCright B.... Virshup D.M. (J. Biol. Chem. 1996)
    6. Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). (PubMed id 9272177)1, 9 Forbes S.A....Kas K. (Hum. Genet. 1997)
    7. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)
    8. Selective proteasomal degradation of the B'I^ subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. (PubMed id 23135275)1 Oberg E.A....Strack S. (J. Biol. Chem. 2012)
    9. Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. (PubMed id 21329884)2 Rodgers J.T.... Puigserver P. (Mol. Cell 2011)
    10. PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. (PubMed id 21072166)1 Godet A.N....Garcia A. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5526 HGNC: 9310 AceView: PPP2R5B Ensembl:ENSG00000068971 euGenes: HUgn5526
    ECgene: PPP2R5B Kegg: 5526 H-InvDB: PPP2R5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R5B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R5B gene:
    Search GeneIP for patents involving PPP2R5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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