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PPP2R5B Gene

protein-coding GIFtS: 61
GCID: GC11P064692

Protein Phosphatase 2, Regulatory Subunit B', Beta

(Previous names: protein phosphatase 2, regulatory subunit B (B56), beta...)

See PPP2R5B-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Protein Phosphatase 2, Regulatory Subunit B', Beta¹ ²		B56 Beta Isoform¹
Protein Phosphatase 2, Regulatory Subunit B', Beta Isoform¹ ²		Beta Isoform¹
PP2A B Subunit Isoform B'-Beta² ³		PR61 Beta Isoform¹
PP2A B Subunit Isoform B56-Beta² ³		Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform¹
PP2A B Subunit Isoform PR61-Beta² ³		R5 Beta Isoform¹
PP2A B Subunit Isoform R5-Beta² ³		Serine/Threonine Protein Phosphatase 2A¹
56 KDa Regulatory Subunit¹		B56B²
PP2A¹		PR61B²
B Subunit¹		Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta Isoform²
B' Beta Isoform¹		Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Beta Isoform²

External Ids:	HGNC: 9310¹	Entrez Gene: 5526²	Ensembl: ENSG00000068971⁷	OMIM: 601644⁵	UniProtKB: Q15173³

Export aliases for PPP2R5B gene to outside databases

Previous GC identifers: GC11P067208 GC11P066373 GC11P064942 GC11P064468 GC11P064469 GC11P064448 GC11P061019

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R5B Gene:

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one

of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.

It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant

regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might

modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit

B56 subfamily. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R5B Gene:

PPP2R5B (protein phosphatase 2, regulatory subunit B', beta) is a protein-coding gene. Diseases associated with PPP2R5B include pancreatic gastrinoma, and wermer syndrome. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5D.

UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might

direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form

mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308'

and 'Ser-373' residues

Gene Wiki entry for PPP2R5B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000011.9 NT_167190.2 NC_018922.2

Regulatory elements:

Regulatory transcription factor binding sites in the PPP2R5B gene promoter:
Egr-3 TBP NF-1 p53 Sp1 Ik-3 YY1 C/EBPalpha FOXC1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPP2R5B promoter sequence

Search Chromatin IP Primers for PPP2R5B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q12

PPP2R5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P064692: view genomic region (about GC identifiers)

Start:	64,685,025 bp from pter	End:	64,701,950 bp from pter
Size:	16,926 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Size: 497 amino acids; 57393 Da

Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)

and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory

subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the

R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral

proteins, and cell signaling molecules. Interacts with SGOL1. Interacts with AKT1

Secondary accessions: Q13853

Alternative splicing: 2 isoforms: Q15173-1 Q15173-2

Explore the universe of human proteins at neXtProt for PPP2R5B: NX_Q15173

Explore proteomics data for PPP2R5B at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See PPP2R5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006235.1

ENSEMBL proteins:

ENSP00000437088 ENSP00000164133 ENSP00000436136

Reactome Protein details: Q15173

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

2 InterPro protein domains:

IPR002554 PP2A_B56

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q15173

ProtoNet protein and cluster: Q15173

1 Blocks protein domain: IPB002554 Protein phosphatase 2A

UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173

Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family

Find genes that share domains with PPP2R5B About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: 2A5B_HUMAN, Q15173

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might

direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form

mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308'

and 'Ser-373' residues

Induction: By retinoic acid; in neuroblastoma cell lines

Genatlas biochemistry entry for PPP2R5B:

protein phosphatase 2B,regulatory subunit B56 beta isoform,expressed in brain,with CAG repeat,excluded as a

candidate gene for MEN1

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	15380617
GO:0008601	protein phosphatase type 2A regulator activity	IEA	--

Find genes that share ontologies with PPP2R5B About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for PPP2R5B:

Decreased focal adhesion (FA)

Animal Models:

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

2A5B_HUMAN, Q15173: Cytoplasm

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
golgi apparatus	1
nucleus	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000159	protein phosphatase type 2A complex	IEA	--
GO:0005737	cytoplasm	TAS	8703017
GO:0005829	cytosol	TAS	--

Find genes that share ontologies with PPP2R5B About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for PPP2R5B About (see all 40)

See pathways by source

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by

SuperPath

Contained pathways About

CD28 co-stimulation

	Costimulation by the CD28 family	0.44			CTLA4 Signaling	0.30
	CTLA4 inhibitory signaling	0.32

Mitotic Metaphase and Anaphase

	Separation of Sister Chromatids	0.94			Mitotic Metaphase and Anaphase	0.93
	Mitotic Anaphase	0.94

Cell Cycle, Mitotic

	Cell Cycle, Mitotic	0.90			M Phase	0.62
	Cell Cycle	0.90

p70S6K Signaling

	p70S6K Signaling	0.60			mTOR Pathway	0.54
	Renin-Angiotensin Pathway	0.60

Unfolded Protein Response

	Unfolded Protein Response	0.61			Activation of Chaperone Genes by XBP1(S)	0.59
	Activation of Chaperones by IRE1alpha	0.61

Find genes that share SuperPaths with PPP2R5B About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R5B (see all 25)

	Cell Cycle Control by BTG Proteins
	Telomerase Components in Cell Signaling
	CDK5 Pathway
	mTOR Pathway
	Cyclins and Cell Cycle Regulation

4 GeneGo (Thomson Reuters) Pathways for PPP2R5B

	Signal transduction PKA signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

2 BioSystems Pathways for PPP2R5B

	Glycogen Metabolism
	IL-6 Signaling Pathway

Selected Reactome Pathways for PPP2R5B (see all 9)

	Resolution of Sister Chromatid Cohesion
	Mitotic Prometaphase
	Degradation of beta-catenin by the destruction complex
	XBP1(S) activates chaperone genes
	Separation of Sister Chromatids

5 Kegg Pathways (Kegg details for PPP2R5B):

	mRNA surveillance pathway
	Oocyte meiosis
	PI3K-Akt signaling pathway
	Adrenergic signaling in cardiomyocytes
	Dopaminergic synapse

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PPP2R5B
Interactions:

Search GeneGlobe Interaction Network for PPP2R5B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PPP2R5B (Q15173^{1, 2, 3} ENSP00000164133⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 115)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000206478	P46695¹^,²^,³	EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1
ENSG00000227231	P46695¹^,²^,³	EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1
ENSG00000230128	P46695¹^,²^,³	EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1
IER3	P46695¹^,²^,³	EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1
ENSG00000235030	P46695¹^,²^,³, ENSP00000412283⁴	EBI-1369497,EBI-1748945 MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 STRING: ENSP00000412283

About this table

Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006987	activation of signaling protein activity involved in unfolded protein response	TAS	--
GO:0007165	signal transduction	--	--
GO:0030968	endoplasmic reticulum unfolded protein response	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

Find genes that share ontologies with PPP2R5B About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PPP2R5B (2A5B)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for PPP2R5B gene (3 alternative transcripts):

NM_006244.3 XM_006718606.1 XM_006718607.1

Unigene Cluster for PPP2R5B:

Protein phosphatase 2, regulatory subunit B', beta

Hs.75199 [show with all ESTs]

Unigene Representative Sequence: NM_006244

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000413292 ENST00000526559 ENST00000164133(uc001oby.3) ENST00000532850

ENST00000528530

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Additional mRNA sequence:

AK092730.1 BC045619.1 L42374.1

10 DOTS entries:

DT.448055 DT.40115701 DT.102823186 DT.100755008 DT.95264992 DT.95264998 DT.100755007 DT.216640

DT.95136357 DT.95199134

Selected AceView cDNA sequences (see all 128):

BM680916 BQ446332 AK092730 F11602 AA338665 AI471724 AI621363 BG056519

F12879 L42374 AI142483 R35256 BM665417 AW300636 F11874 CA842477

T33432 BQ716698 F09521 CD742806 T32092 CR621212 CA390311 BX094477

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP2R5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTCTACTCCT

About this image

PPP2R5B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Gut Tube (Gastrointestinal Tract) fully expand to see all 2 entries
Foregut

Eye (Sensory Organs)
Retina

PPP2R5B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PPP2R5B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.75199

UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173

Tissue specificity: Highest expression in brain

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5B gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ppp2r5b^{1 , 5}	protein phosphatase 2, regulatory subunit B (B56), more⁵ protein phosphatase 2, regulatory subunit B', beta¹	92.42(n)¹ 98.79(a)¹		19 (4.35 cM)⁵ 225849¹ NM_198168.3¹ NP_937811.1¹ 6227765⁵
tropical clawed frog (Xenopus tropicalis)	Amphibia	ppp2r5b¹	protein phosphatase 2, regulatory subunit B', beta	76.03(n) 86.16(a)		100101792 NM_001100279.1 NP_001093749.1
zebrafish (Danio rerio)	Actinopterygii	LOC562282¹	serine/threonine-protein phosphatase 2A 56 kDa regulatory more	76.32(n) 83.09(a)		562282 XM_685678.3 XP_690770.2
fruit fly (Drosophila melanogaster)	Insecta	BcDNA:LD34343³	protein serine/threonine phosphatase	75(a)		98A6 --
worm (Caenorhabditis elegans)	Secernentea	W08G11.4³	RTS1 PROTEIN (SCS1 PROTEIN)	64(a)		V(16360199-16362996) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RTS1⁶	B-type regulatory subunit of protein phosphatase 2...	32(a)	1 → many	XV(357674-359947) YOR014W
Alicante grape (Vitis vinifera)	eudicotyledons	Vvi.10909²	Vitis vinifera transcribed sequence with moderate similarity more	73.04(n)		CB006035.1

ENSEMBL Gene Tree for PPP2R5B (if available)
TreeFam Gene Tree for PPP2R5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for PPP2R5B gene

PPP2R5D² PPP2R5A² PPP2R5C² PPP2R5E²

4 SIMAP similar genes for PPP2R5B using alignment to 3 protein entries: 2A5B_HUMAN (see all proteins):

PPP2R5A PPP2R5E PPP2R5C PPP2R5D

Find genes that share paralogs with PPP2R5B About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138959651^1,2	C	--	64690220(+)	`TGGGCA/GCCTGA`	1	--	us2k¹		0	--	--	--	--
rs184270518^1,2		--	64690225(+)	`GCCTGA/CAGTCC`	1	--	us2k¹		0	--	--	--	--
rs646852^1,2	C,A,H	--	64690241(-)	`gcctcT/Ccgaat`	1	--	us2k¹		7		NA CSA	14
rs189081486^1,2		--	64690274(+)	`CCCAGC/GAGGCG`	1	--	us2k¹		0	--	--	--	--
rs145880345^1,2		--	64690573(+)	`ATTACA/TGGTAT`	1	--	us2k¹		0	--	--	--	--
rs148176735^1,2		--	64690771(+)	`GCTTCG/TCCTCT`	1	--	us2k¹		0	--	--	--	--
rs616322^1,2	C,F,A,H	--	64690875(-)	`TCTCCC/GTCCTT`	1	--	us2k¹ trp³		8		MN NS EA NA	1014
rs150621087^1,2		--	64690920(+)	`GGGCCG/TGATGG`	1	--	us2k¹		0	--	--	--	--
rs138758445^1,2		--	64690981(+)	`AGTGCA/CGGAGT`	1	--	us2k¹		0	--	--	--	--
rs76891350^1,2	C,F	--	64690994(+)	`TGGACC/TCCAGC`	1	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for PPP2R5B (64685025 - 64701950 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for PPP2R5B: About this table

Variant ID	Type	Subtype	PubMed ID
dgv1173n71	CNV	Loss	21882294
nsv528506	CNV	Loss	19592680
dgv1171n71	CNV	Loss	21882294
nsv526181	CNV	Gain	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 601644 OMIM disorders: --

3 diseases for PPP2R5B:
About MalaCards

pancreatic gastrinoma wermer syndrome cavernous malformation

2 inferred disease relationships from the University of Copenhagen DISEASES database for PPP2R5B:

Pancreatic gastrinoma Wermer syndrome

Find genes that share disorders with PPP2R5B About GenesLikeMe

Export disorders for PPP2R5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PPP2R5B gene, integrated from 10 sources (see all 31):
(articles sorted by number of sources associating them with PPP2R5B)

Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)^{1, 2, 3} McCright B. and Virshup D.M. (J. Biol. Chem. 1995)
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)^{1, 2} Kitajima T.S.... Watanabe Y. (Nature 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PubMed id 8694763)^{1, 2} Zolnierowicz S.... Hemmings B.A. (Biochem. J. 1996)
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PubMed id 8703017)^{1, 2} McCright B.... Virshup D.M. (J. Biol. Chem. 1996)
Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). (PubMed id 9272177)^{1, 9} Forbes S.A....Kas K. (Hum. Genet. 1997)
A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)¹ Shamay M....Hayward S.D. (J. Virol. 2012)
Selective proteasomal degradation of the B'I^ subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. (PubMed id 23135275)¹ Oberg E.A....Strack S. (J. Biol. Chem. 2012)
Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. (PubMed id 21329884)² Rodgers J.T.... Puigserver P. (Mol. Cell 2011)
PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. (PubMed id 21072166)¹ Godet A.N....Garcia A. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5526	HGNC: 9310	AceView: PPP2R5B	Ensembl:ENSG00000068971	euGenes: HUgn5526
ECgene: PPP2R5B	Kegg: 5526	H-InvDB: PPP2R5B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PPP2R5B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PPP2R5B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PPP2R5B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PPP2R5B gene:
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PPP2R5B Gene

Protein Phosphatase 2, Regulatory Subunit B', Beta

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PPP2R5B (Gene Symbol)
Protein Phosphatase 2, Regulatory Subunit B', Beta
Protein Phosphatase 2, Regulatory Subunit B', Beta Isoform
PP2A B Subunit Isoform B'-Beta
PP2A B Subunit Isoform B56-Beta
PP2A B Subunit Isoform PR61-Beta
PP2A B Subunit Isoform R5-Beta
56 KDa Regulatory Subunit
PP2A
B Subunit
B' Beta Isoform
B56 Beta Isoform
Beta Isoform
PR61 Beta Isoform
Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform
R5 Beta Isoform
Serine/Threonine Protein Phosphatase 2A
B56B
PR61B
Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta Isoform
Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Beta Isoform

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PPP2R5B Gene

Protein Phosphatase 2, Regulatory Subunit B', Beta

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