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Aliases for PPP2R5B Gene

Aliases for PPP2R5B Gene

  • Protein Phosphatase 2, Regulatory Subunit B', Beta 2
  • Protein Phosphatase 2, Regulatory Subunit B, Beta Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Beta 2 3
  • PP2A B Subunit Isoform PR61-Beta 3 4
  • PP2A B Subunit Isoform B56-Beta 3 4
  • PP2A B Subunit Isoform R5-Beta 3 4
  • PP2A B Subunit Isoform B-Beta 3 4
  • Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta Isoform 3
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform 2
  • Serine/Threonine Protein Phosphatase 2A 2
  • 56 KDa Regulatory Subunit 2
  • PR61 Beta Isoform 2
  • B56 Beta Isoform 2
  • R5 Beta Isoform 2
  • B Beta Isoform 2
  • Beta Isoform 2
  • B Subunit 2
  • PR61B 3
  • PP2A 2
  • B56B 3

External Ids for PPP2R5B Gene

Previous GeneCards Identifiers for PPP2R5B Gene

  • GC11P067208
  • GC11P066373
  • GC11P064942
  • GC11P064468
  • GC11P064469
  • GC11P064448
  • GC11P064692
  • GC11P061019

Summaries for PPP2R5B Gene

Entrez Gene Summary for PPP2R5B Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R5B Gene

PPP2R5B (Protein Phosphatase 2, Regulatory Subunit B', Beta) is a Protein Coding gene. Diseases associated with PPP2R5B include pancreatic gastrinoma. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5E.

UniProtKB/Swiss-Prot for PPP2R5B Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the Thr-308 and Ser-373 residues.

Gene Wiki entry for PPP2R5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5B Gene

Genomics for PPP2R5B Gene

Regulatory Elements for PPP2R5B Gene

Genomic Location for PPP2R5B Gene

Chromosome:
11
Start:
64,917,553 bp from pter
End:
64,934,478 bp from pter
Size:
16,926 bases
Orientation:
Plus strand

Genomic View for PPP2R5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5B Gene

Proteins for PPP2R5B Gene

  • Protein details for PPP2R5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15173-2A5B_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
    Protein Accession:
    Q15173
    Secondary Accessions:
    • Q13853

    Protein attributes for PPP2R5B Gene

    Size:
    497 amino acids
    Molecular mass:
    57393 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. Interacts with AKT1.

    Alternative splice isoforms for PPP2R5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5B Gene

Proteomics data for PPP2R5B Gene at MOPED

Post-translational modifications for PPP2R5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP2R5B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PPP2R5B Gene

Domains & Families for PPP2R5B Gene

Gene Families for PPP2R5B Gene

Protein Domains for PPP2R5B Gene

Suggested Antigen Peptide Sequences for PPP2R5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15173

UniProtKB/Swiss-Prot:

2A5B_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5B: view

Function for PPP2R5B Gene

Molecular function for PPP2R5B Gene

GENATLAS Biochemistry:
protein phosphatase 2B,regulatory subunit B56 beta isoform,expressed in brain,with CAG repeat,excluded as a candidate gene for MEN1
UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the Thr-308 and Ser-373 residues.
UniProtKB/Swiss-Prot Induction:
By retinoic acid; in neuroblastoma cell lines

Gene Ontology (GO) - Molecular Function for PPP2R5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 7592815
GO:0008601 protein phosphatase type 2A regulator activity IEA --
genes like me logo Genes that share ontologies with PPP2R5B: view
genes like me logo Genes that share phenotypes with PPP2R5B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPP2R5B Gene

Localization for PPP2R5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R5B Gene COMPARTMENTS Subcellular localization image for PPP2R5B gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for PPP2R5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IEA --
GO:0005737 cytoplasm TAS 8703017
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP2R5B: view

Pathways & Interactions for PPP2R5B Gene

SuperPathways for PPP2R5B Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 S45 mutants of beta-catenin arent phosphorylated
3 Immune System
4 p70S6K Signaling
5 Cell Cycle, Mitotic
.62
genes like me logo Genes that share pathways with PPP2R5B: view

SIGNOR curated interactions for PPP2R5B Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PPP2R5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation --
GO:0007165 signal transduction --
GO:0010469 regulation of receptor activity IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
genes like me logo Genes that share ontologies with PPP2R5B: view

Drugs & Compounds for PPP2R5B Gene

No Compound Related Data Available

Transcripts for PPP2R5B Gene

Unigene Clusters for PPP2R5B Gene

Protein phosphatase 2, regulatory subunit B, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5B Gene

No ASD Table

Relevant External Links for PPP2R5B Gene

GeneLoc Exon Structure for
PPP2R5B
ECgene alternative splicing isoforms for
PPP2R5B

Expression for PPP2R5B Gene

mRNA expression in normal human tissues for PPP2R5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R5B Gene

This gene is overexpressed in Fetal Brain (19.5), Plasma (18.6), and Spinal cord (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R5B Gene



SOURCE GeneReport for Unigene cluster for PPP2R5B Gene Hs.75199

mRNA Expression by UniProt/SwissProt for PPP2R5B Gene

Q15173-2A5B_HUMAN
Tissue specificity: Highest expression in brain
genes like me logo Genes that share expression patterns with PPP2R5B: view

Protein tissue co-expression partners for PPP2R5B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP2R5B Gene

Orthologs for PPP2R5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2R5B 35
  • 94.02 (n)
  • 99.19 (a)
PPP2R5B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R5B 35
  • 93.96 (n)
  • 99.2 (a)
PPP2R5B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r5b 35
  • 92.42 (n)
  • 98.79 (a)
Ppp2r5b 16
Ppp2r5b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R5B 35
  • 99.66 (n)
  • 99.6 (a)
PPP2R5B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r5b 35
  • 92.09 (n)
  • 98.99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r5b 35
  • 76.03 (n)
  • 86.16 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562282 35
  • 76.32 (n)
  • 83.09 (a)
PPP2R5B 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD34343 37
  • 75 (a)
wdb 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W08G11.4 37
  • 64 (a)
pptr-1 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 36
  • 32 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10909 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
ManyToMany
Species with no ortholog for PPP2R5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R5B Gene

ENSEMBL:
Gene Tree for PPP2R5B (if available)
TreeFam:
Gene Tree for PPP2R5B (if available)

Paralogs for PPP2R5B Gene

Paralogs for PPP2R5B Gene

(4) SIMAP similar genes for PPP2R5B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPP2R5B: view

Variants for PPP2R5B Gene

Sequence variations from dbSNP and Humsavar for PPP2R5B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs584715 -- 64,920,864(-) gatca(C/T)gaggt intron-variant
rs597423 -- 64,931,196(-) TTTGC(A/C)AAAGG intron-variant
rs597913 -- 64,931,077(-) atagc(A/C)agaca intron-variant
rs601047 -- 64,926,132(-) ACCTC(C/T)AAGGA intron-variant
rs601805 -- 64,919,381(-) GCTCT(A/C)GATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5B Gene

Variant ID Type Subtype PubMed ID
nsv528506 CNV Loss 19592680
dgv1171n71 CNV Loss 21882294
dgv1173n71 CNV Loss 21882294
nsv526181 CNV Gain 19592680

Variation tolerance for PPP2R5B Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R5B Gene

HapMap Linkage Disequilibrium report
PPP2R5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5B Gene

Disorders for PPP2R5B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP2R5B Gene - From: DISEASES

Disorder Aliases PubMed IDs
pancreatic gastrinoma
  • pancreatic g-cell tumor
- elite association

Relevant External Links for PPP2R5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R5B
genes like me logo Genes that share disorders with PPP2R5B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R5B Gene

Publications for PPP2R5B Gene

  1. Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). (PMID: 9272177) Forbes S.A. … Kas K. (Hum. Genet. 1997) 23 67
  2. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B. … Virshup D.M. (J. Biol. Chem. 1995) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes. (PMID: 23287597) Comandini A. … Franzese O. (Mol. Immunol. 2013) 67
  5. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 67

Products for PPP2R5B Gene

Sources for PPP2R5B Gene

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