Aliases for PPP2R5B Gene
Aliases for PPP2R5B Gene
- Protein Phosphatase 2 Regulatory Subunit B', Beta 2
- Protein Phosphatase 2 Regulatory Subunit B, Beta 2 3 5
- Protein Phosphatase 2, Regulatory Subunit B, Beta Isoform 2 3
- PP2A B Subunit Isoform PR61-Beta 3 4
- PP2A B Subunit Isoform B56-Beta 3 4
- PP2A B Subunit Isoform R5-Beta 3 4
- PP2A B Subunit Isoform B-Beta 3 4
- Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta Isoform 3
- Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform 2
- Protein Phosphatase 2, Regulatory Subunit B, Beta 2
- Serine/Threonine Protein Phosphatase 2A 2
External Ids for PPP2R5B Gene
- HGNC: 9310
- Entrez Gene: 5526
- Ensembl: ENSG00000068971
- OMIM: 601644
- UniProtKB: Q15173
Previous GeneCards Identifiers for PPP2R5B Gene
- GC11P067208
- GC11P066373
- GC11P064942
- GC11P064468
- GC11P064469
- GC11P064448
- GC11P064692
- GC11P061019
Summaries for PPP2R5B Gene
-
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2R5B Gene
PPP2R5B (Protein Phosphatase 2 Regulatory Subunit B', Beta) is a Protein Coding gene. Diseases associated with PPP2R5B include Pancreatic Gastrinoma. Among its related pathways are CTLA4 Signaling and Negative regulation of MAPK pathway. GO annotations related to this gene include binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5E.
UniProtKB/Swiss-Prot for PPP2R5B Gene
-
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the Thr-308 and Ser-373 residues.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5B Gene
Genomics for PPP2R5B Gene
Regulatory Elements for PPP2R5B Gene
Enhancers for PPP2R5B Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PPP2R5B on UCSC Golden Path with GeneCards custom track
Promoters for PPP2R5B Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PPP2R5B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PPP2R5B gene promoter:
Regulatory Element Products
Genomic Location for PPP2R5B Gene
- Chromosome:
- 11
- Start:
- 64,917,553 bp from pter
- End:
- 64,934,478 bp from pter
- Size:
- 16,926 bases
- Orientation:
- Plus strand
Genomic View for PPP2R5B Gene
Genes around PPP2R5B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q12 by Entrez Gene
- 11q12 by HGNC
PPP2R5B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP2R5B Gene
Proteins for PPP2R5B Gene
-
Protein details for PPP2R5B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15173-2A5B_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
- Protein Accession:
- Q15173
- Q13853
Protein attributes for PPP2R5B Gene
- Size:
- 497 amino acids
- Molecular mass:
- 57393 Da
- Quaternary structure:
-
- PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. Interacts with AKT1.
Protein Expression for PPP2R5B Gene
Post-translational modifications for PPP2R5B Gene
Other Protein References for PPP2R5B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PPP2R5B
- Invitrogen Antibodies for PPP2R5B
- antibodies-online Antibodies for PPP2R5B: See all 25
- GeneTex PPP2R5B antibody for PPP2R5B
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R5B
Protein Products
-
OriGene Purified Proteins for PPP2R5B
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- antibodies-online Proteins for PPP2R5B: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PPP2R5B
Assay Products
No data available for DME Specific Peptides for PPP2R5B Gene
Domains & Families for PPP2R5B Gene
Gene Families for PPP2R5B Gene
Protein Domains for PPP2R5B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP2R5B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15173- Family:
-
- Belongs to the phosphatase 2A regulatory subunit B56 family.
Function for PPP2R5B Gene
Molecular function for PPP2R5B Gene
- GENATLAS Biochemistry:
- protein phosphatase 2B,regulatory subunit B56 beta isoform,expressed in brain,with CAG repeat,excluded as a candidate gene for MEN1
- UniProtKB/Swiss-Prot Function:
- The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the Thr-308 and Ser-373 residues.
- UniProtKB/Swiss-Prot Induction:
- By retinoic acid; in neuroblastoma cell lines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005488 | binding | IEA | -- |
Phenotypes for PPP2R5B Gene
- GenomeRNAi human phenotypes for PPP2R5B:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Decreased viability
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R5B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R5B gene
- Search ViGene Biosciences for PPP2R5B
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R5B
- GenScript: Design CRISPR guide RNA sequences for PPP2R5B
miRNA Products
- Search ViGene Biosciences for PPP2R5B
Clone Products
- OriGene clones in human for PPP2R5B
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- Addgene plasmids for PPP2R5B
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PPP2R5B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R5B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R5B gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPP2R5B Gene
Localization for PPP2R5B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 1 |
No data available for Gene Ontology (GO) - Cellular Components for PPP2R5B Gene
Pathways & Interactions for PPP2R5B Gene
More details on SuperPathways for PPP2R5B| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Interleukin-3, 5 and GM-CSF signaling |
.95
|
|
| 2 | S45 mutants of beta-catenin arent phosphorylated | ||
| 3 | PI3K events in ERBB4 signaling |
.82
|
|
| 4 | Beta-Adrenergic Signaling |
.36
|
|
| 5 | p70S6K Signaling |
.60
|
.54
|
Pathways by source for PPP2R5B Gene
2 BioSystems pathways for PPP2R5B Gene
116 Reactome pathways for PPP2R5B Gene
7 KEGG pathways for PPP2R5B Gene
4 GeneGo (Thomson Reuters) pathways for PPP2R5B Gene
25 Qiagen pathways for PPP2R5B Gene
Interacting Proteins for PPP2R5B Gene
Selected Interacting proteins:
Q15173-2A5B_HUMAN
ENSP00000164133
for PPP2R5B Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0010976 | positive regulation of neuron projection development | IEA | -- |
| GO:0030968 | endoplasmic reticulum unfolded protein response | TAS | -- |
| GO:0031334 | positive regulation of protein complex assembly | IEA | -- |
Transcripts for PPP2R5B Gene
mRNA/cDNA for PPP2R5B Gene
- (5) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (128) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPP2R5B Gene
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R5B
- GenScript: Design CRISPR guide RNA sequences for PPP2R5B
miRNA Products
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Clone Products
- OriGene clones in human for PPP2R5B
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PPP2R5B
Flow Cytometry Products
Expression for PPP2R5B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Fetal Brain (19.5), Plasma (18.6), and Spinal cord (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R5B Gene
SOURCE GeneReport for Unigene cluster for PPP2R5B Gene Hs.75199
mRNA Expression by UniProt/SwissProt for PPP2R5B Gene
Q15173-2A5B_HUMAN
Tissue specificity:
Highest expression in brain.
Primer Products
-
OriGene qPCR primer pairs and template standards for PPP2R5B
-
OriGene qPCR primer pairs for PPP2R5B
No data available for mRNA differential expression in normal tissues for PPP2R5B Gene
Orthologs for PPP2R5B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PPP2R5B 35 |
|
||
| PPP2R5B 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PPP2R5B 35 |
|
||
| PPP2R5B 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ppp2r5b 35 |
|
||
| Ppp2r5b 16 |
|
||||
| Ppp2r5b 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PPP2R5B 35 |
|
||
| PPP2R5B 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ppp2r5b 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp2r5b 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC562282 35 |
|
||
| PPP2R5B 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | BcDNA:LD34343 37 |
|
|
|
| wdb 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | W08G11.4 37 |
|
|
|
| pptr-1 36 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RTS1 36 |
|
OneToMany | |
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10909 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany |
- Species with no ortholog for PPP2R5B:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PPP2R5B Gene
(4) SIMAP similar genes for PPP2R5B Gene using alignment to 3 proteins:
Variants for PPP2R5B Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs584715 | -- | 64,920,864(-) | gatca(C/T)gaggt | intron-variant | |
| rs597423 | -- | 64,931,196(-) | TTTGC(A/C)AAAGG | intron-variant | |
| rs597913 | -- | 64,931,077(-) | atagc(A/C)agaca | intron-variant | |
| rs601047 | -- | 64,926,132(-) | ACCTC(C/T)AAGGA | intron-variant | |
| rs601805 | -- | 64,919,381(-) | GCTCT(A/C)GATTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv528506 | CNV | Loss | 19592680 |
| dgv1171n71 | CNV | Loss | 21882294 |
| dgv1173n71 | CNV | Loss | 21882294 |
| nsv526181 | CNV | Gain | 19592680 |
Residual Variation Intolerance Score:
17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.56;
12.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PPP2R5B Gene
- Human Gene Mutation Database (HGMD)
- PPP2R5B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5B Gene
Disorders for PPP2R5B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic gastrinoma |
|
|
Search PPP2R5B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PPP2R5B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PPP2R5B
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R5B Gene
Publications for PPP2R5B Gene
- Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B. … Virshup D.M. (J. Biol. Chem. 1995) 2 3 4 67
- Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). (PMID: 9272177) Forbes S.A. … Kas K. (Hum. Genet. 1997) 3 23
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes. (PMID: 23287597) Comandini A. … Franzese O. (Mol. Immunol. 2013) 3
- A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 3
Products for PPP2R5B Gene
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- OriGene qPCR primer pairs for PPP2R5B
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- Addgene plasmids for PPP2R5B
- antibodies-online Antibodies for PPP2R5B: See all 25
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- antibodies-online Proteins for PPP2R5B: See all 5
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- GeneTex PPP2R5B antibody for PPP2R5B
- Search GeneTex for Proteins for PPP2R5B
- ViGene Biosciences adenoviral particle packaged cDNA for PPP2R5B gene
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- ViGene Biosciences lentiviral particle packaged cDNA for PPP2R5B gene
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- ViGene Biosciences ready-to-package AAV shRNAs for PPP2R5B gene
- ViGene Biosciences ready-to-package AAV shRNAs for PPP2R5B gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R5B
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- Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R5B
Sources for PPP2R5B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon