Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP2R5B Gene

protein-coding   GIFtS: 62
GCID: GC11P064692

Protein Phosphatase 2, Regulatory Subunit B', Beta

(Previous names: protein phosphatase 2, regulatory subunit B (B56), beta...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 2, Regulatory Subunit B', Beta1 2     B56 Beta Isoform1
Protein Phosphatase 2, Regulatory Subunit B', Beta Isoform1 2     Beta Isoform1
PP2A B Subunit Isoform B'-Beta2 3     PR61 Beta Isoform1
PP2A B Subunit Isoform B56-Beta2 3     Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform1
PP2A B Subunit Isoform PR61-Beta2 3     R5 Beta Isoform1
PP2A B Subunit Isoform R5-Beta2 3     Serine/Threonine Protein Phosphatase 2A1
56 KDa Regulatory Subunit1     B56B2
PP2A1     PR61B2
B Subunit1     Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta
Isoform2
B' Beta Isoform1     Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Beta
Isoform2

External Ids:    HGNC: 93101   Entrez Gene: 55262   Ensembl: ENSG000000689717   OMIM: 6016445   UniProtKB: Q151733   

Export aliases for PPP2R5B gene to outside databases

Previous GC identifers: GC11P067208 GC11P066373 GC11P064942 GC11P064468 GC11P064469 GC11P064448 GC11P061019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R5B Gene:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one
of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant
regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might
modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit
B56 subfamily. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R5B Gene: 
PPP2R5B (protein phosphatase 2, regulatory subunit B', beta) is a protein-coding gene. Diseases associated with PPP2R5B include pancreatic gastrinoma, and cerebral cavernous malformations 3, and among its related super-pathways are Costimulation by the CD28 family and Mitotic Anaphase. GO annotations related to this gene include protein binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5D.

UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form
mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308'
and 'Ser-373' residues

Gene Wiki entry for PPP2R5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP2R5B gene promoter:
         Egr-3   TBP   NF-1   p53   Sp1   Ik-3   YY1   C/EBPalpha   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2R5B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP2R5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q12

PPP2R5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R5B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064692:  view genomic region     (about GC identifiers)

Start:
64,685,025 bp from pter      End:
64,701,950 bp from pter
Size:
16,926 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform  
Size: 497 amino acids; 57393 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Interacts with SGOL1. Interacts with AKT1
Subcellular location: Cytoplasm
Secondary accessions: Q13853
Alternative splicing: 2 isoforms:  Q15173-1   Q15173-2   

Explore the universe of human proteins at neXtProt for PPP2R5B: NX_Q15173

Explore proteomics data for PPP2R5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15173

  • PPP2R5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP2R5B Protein Expression
    REFSEQ proteins: NP_006235.1  
    ENSEMBL proteins: 
     ENSP00000437088   ENSP00000164133   ENSP00000436136  
    Reactome Protein details: Q15173
    Human Recombinant Protein Products for PPP2R5B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPP2R5B
    OriGene Protein Over-expression Lysate for PPP2R5B
    OriGene MassSpec for PPP2R5B 
    OriGene Custom Protein Services for PPP2R5B
    GenScript Custom Purified and Recombinant Proteins Services for PPP2R5B
    Novus Biologicals PPP2R5B Protein
    Novus Biologicals PPP2R5B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex IEA--
    GO:0005737cytoplasm TAS8703017
    GO:0005829cytosol TAS--

    PPP2R5B for ontologies           About GeneDecksing



    PPP2R5B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PPP2R5B
    OriGene Custom Antibody Services for PPP2R5B
    GenScript Custom Superior Antibodies Services for PPP2R5B
    Novus Biologicals PPP2R5B Antibodies
    Abcam antibodies for PPP2R5B
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PPP2R5B
    LSBio Antibodies in human, mouse, rat for PPP2R5B 

    Assay Products for PPP2R5B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP2R5B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP2R5B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    2 InterPro protein domains:
     IPR002554 PP2A_B56
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q15173

    ProtoNet protein and cluster: Q15173

    1 Blocks protein domain: IPB002554 Protein phosphatase 2A

    UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173
    Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family


    PPP2R5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2A5B_HUMAN, Q15173
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form
    mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308'
    and 'Ser-373' residues
    Induction: By retinoic acid; in neuroblastoma cell lines

         Genatlas biochemistry entry for PPP2R5B:
    protein phosphatase 2B,regulatory subunit B56 beta isoform,expressed in brain,with CAG repeat,excluded as a
    candidate gene for MEN1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15380617
    GO:0008601protein phosphatase type 2A regulator activity IEA--
         
    PPP2R5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP2R5B:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP2R5B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP2R5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R5B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R5B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP2R5B
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2R5B (see all 13):
    hsa-miR-320a hsa-miR-330-5p hsa-miR-320d hsa-miR-331-3p hsa-miR-3126-5p hsa-miR-361-3p hsa-miR-320b hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP2R5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2R5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP2R5B
    Sirion Biotech Customized adenovirus for overexpression of PPP2R5B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PPP2R5B (see all 7)
    OriGene ORF clones in mouse, rat for PPP2R5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP2R5B (NM_006244)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R5B
    Sirion Biotech Customized lentivirus for stable overexpression of PPP2R5B 
                         Customized lentivirus expression plasmids for stable overexpression of PPP2R5B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP2R5B
    Search LifeMap BioReagents cell lines for PPP2R5B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP2R5B About   (see all 39)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    4p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    5Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37
    CDK5 Pathway0.36
    Erythropoietin Pathway0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PPP2R5B
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Signal transduction PKA signaling

    5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2R5B (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    4 GeneGo (Thomson Reuters) Pathways for PPP2R5B
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    2 BioSystems Pathways for PPP2R5B
        Glycogen Metabolism
    IL-6 Signaling Pathway

    5/24        Reactome Pathways for PPP2R5B (see all 24)
        Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Costimulation by the CD28 family
    Cell Cycle
    M Phase


    4         Kegg Pathways  (Kegg details for PPP2R5B):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Dopaminergic synapse


    PPP2R5B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP2R5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for PPP2R5B (Q151731, 2, 3 ENSP000001641334) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206478P466952, 3MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    ENSG00000227231P466952, 3MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    ENSG00000230128P466952, 3MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    IER3P466952, 3MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 
    ENSG00000235030P466952, 3, ENSP000004122834MINT-2835538 MINT-2835492 MINT-2835515 MINT-2835371 I2D: score=1 STRING: ENSP00000412283
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007165signal transduction ----
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--

    PPP2R5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PPP2R5B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP2R5B (2A5B)

    Search CenterWatch for drugs/clinical trials and news about PPP2R5B / 2A5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP2R5B gene: 
    NM_006244.3  

    Unigene Cluster for PPP2R5B:

    Protein phosphatase 2, regulatory subunit B', beta
    Hs.75199  [show with all ESTs]
    Unigene Representative Sequence: NM_006244
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413292 ENST00000526559 ENST00000164133(uc001oby.3) ENST00000532850
    ENST00000528530
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP2R5B
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2R5B (see all 13):
    hsa-miR-320a hsa-miR-330-5p hsa-miR-320d hsa-miR-331-3p hsa-miR-3126-5p hsa-miR-361-3p hsa-miR-320b hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R5B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPP2R5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2R5B
    Clone
    Products:
         
    OriGene clones in human, mouse for PPP2R5B (see all 7)
    OriGene ORF clones in mouse, rat for PPP2R5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP2R5B (NM_006244)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R5B
    Sirion Biotech Customized lentivirus for stable overexpression of PPP2R5B 
                         Customized lentivirus expression plasmids for stable overexpression of PPP2R5B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPP2R5B
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP2R5B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R5B

    Additional mRNA sequence: 

    AK092730.1 BC045619.1 L42374.1 

    10 DOTS entries:

    DT.448055  DT.40115701  DT.102823186  DT.100755008  DT.95264992  DT.95264998  DT.100755007  DT.216640 
    DT.95136357  DT.95199134 

    24/128 AceView cDNA sequences (see all 128):

    AK092730 BX094477 NM_006244 BQ446332 BQ716698 CD742806 CR621212 AI142483 
    F12879 F11602 CA443750 F11874 R35256 AI471724 AI621363 F09521 
    AX747693 BQ441682 T16345 AW300636 BM726309 F08971 CA390311 AA338665 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP2R5B expression in normal human tissues (normalized intensities)      PPP2R5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTACTCCT
    PPP2R5B Expression
    About this image


    PPP2R5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             autonomic/sympathetic/ganglion   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retinal amacrine cell p0   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Midgut
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             umbilical cord reticulocytes   

    See PPP2R5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP2R5B

    SOURCE GeneReport for Unigene cluster: Hs.75199

    UniProtKB/Swiss-Prot: 2A5B_HUMAN, Q15173
    Tissue specificity: Highest expression in brain

        SABiosciences Custom PCR Arrays for PPP2R5B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPP2R5B
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP2R5B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R5B gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r5b1 , 5 protein phosphatase 2, regulatory subunit B (B56), more1, 5 92.42(n)1
    98.79(a)1
      19 (4.35 cM)5
    2258491  NM_198168.31  NP_937811.11 
     62277655 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5622821 serine/threonine-protein phosphatase 2A 56 kDa regulatory more 76.85(n)
    83.76(a)
      562282  XM_685678.2  XP_690770.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD343433 protein serine/threonine phosphatase 75(a)   98A6   --
    worm
    (Caenorhabditis elegans)
    Secernentea W08G11.43 RTS1 PROTEIN (SCS1 PROTEIN) 64(a)   V(16360199-16362996)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS16
    B-type regulatory subunit of protein phosphatase 2...
    32(a)
    1 → many
    XV(357674-359947)
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.109092 Vitis vinifera transcribed sequence with moderate similarity more 73.04(n)    CB006035.1 


    ENSEMBL Gene Tree for PPP2R5B (if available)
    TreeFam Gene Tree for PPP2R5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP2R5B gene
    PPP2R5D2  PPP2R5A2  PPP2R5C2  PPP2R5E2  
    4 SIMAP similar genes for PPP2R5B using alignment to 3 protein entries:     2A5B_HUMAN (see all proteins):
    PPP2R5A    PPP2R5E    PPP2R5C    PPP2R5D

    PPP2R5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/250 SNPs in PPP2R5B are shown (see all 250)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389596511,2
    C--64690220(+) TGGGCA/GCCTGA 1 -- us2k10--------
    rs1842705181,2
    --64690225(+) GCCTGA/CAGTCC 1 -- us2k10--------
    rs6468521,2
    C,A,H--64690241(-) gcctcT/Ccgaat 1 -- us2k17Minor allele frequency- C:0.07NA CSA 14
    rs1890814861,2
    --64690274(+) CCCAGC/GAGGCG 1 -- us2k10--------
    rs1458803451,2
    --64690573(+) ATTACA/TGGTAT 1 -- us2k10--------
    rs1481767351,2
    --64690771(+) GCTTCG/TCCTCT 1 -- us2k10--------
    rs6163221,2
    C,F,A,H--64690875(-) TCTCCC/GTCCTT 1 -- us2k1 trp38Minor allele frequency- G:0.23MN NS EA NA 1014
    rs1506210871,2
    --64690920(+) GGGCCG/TGATGG 1 -- us2k10--------
    rs1387584451,2
    --64690981(+) AGTGCA/CGGAGT 1 -- us2k10--------
    rs768913501,2
    C,F--64690994(+) TGGACC/TCCAGC 1 -- us2k12Minor allele frequency- T:0.14WA 120

    HapMap Linkage Disequilibrium report for PPP2R5B (64685025 - 64701950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP2R5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1173n71CNV Loss21882294
    nsv528506CNV Loss19592680
    dgv1171n71CNV Loss21882294
    nsv526181CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R5B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601644    OMIM disorders: --

    14 diseases for PPP2R5B:    About MalaCards
    pancreatic gastrinoma    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    wermer syndrome    gastrinoma    multiple endocrine neoplasia    cerebritis
    neuroblastoma    kaposi's sarcoma    pancreatitis    sarcoma
    breast cancer    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for PPP2R5B:
    Pancreatic gastrinoma     Wermer syndrome

    PPP2R5B for disorders           About GeneDecksing


    Export disorders for PPP2R5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP2R5B gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PPP2R5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PubMed id 7592815)1, 2, 3 McCright B. and Virshup D.M. (1995)
    2. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PubMed id 8694763)1, 2 Zolnierowicz S.... Hemmings B.A. (1996)
    5. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. (PubMed id 8703017)1, 2 McCright B.... Virshup D.M. (1996)
    6. Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). (PubMed id 9272177)1, 9 Forbes S.A....Kas K. (1997)
    7. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    8. Selective proteasomal degradation of the B'b subunit o f protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. (PubMed id 23135275)1 Oberg E.A....Strack S. (2012)
    9. Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. (PubMed id 21329884)2 Rodgers J.T.... Puigserver P. (2011)
    10. PP2A1 binding, cell transducing and apoptotic propert ies of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. (PubMed id 21072166)1 Godet A.N....Garcia A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5526 HGNC: 9310 AceView: PPP2R5B Ensembl:ENSG00000068971 euGenes: HUgn5526
    ECgene: PPP2R5B Kegg: 5526 H-InvDB: PPP2R5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP2R5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R5B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP2R5B gene:
    Search GeneIP for patents involving PPP2R5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore small molecules (inhibitor) for PPP2R5B
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPP2R5B   OriGene RNAi products in human, mouse, rat for PPP2R5B  
     OriGene qPCR primer pairs and template standards for PPP2R5B   OriGene Protein Over-expression Lysate for PPP2R5B  
     OriGene MassSpec something-or-other for PPP2R5B   OriGene clones in human, mouse for PPP2R5B  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R5B   OriGene Purified Protein for PPP2R5B  
     OriGene ORF clones in mouse, rat for PPP2R5B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP2R5B   OriGene Custom Protein Services for PPP2R5B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP2R5B
     QIAGEN SeqTarget long-range PCR primers for resequencing PPP2R5B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R5B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2R5B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R5B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2R5B
     GenScript Custom Purified and Recombinant Proteins Services for PPP2R5B GenScript cDNA clones with any tag delivered in your preferred vector for PPP2R5B
     GenScript Custom Assay Services for PPP2R5B GenScript Custom Superior Antibodies Services for PPP2R5B
     GenScript Custom overexpressing Cell Line Services for PPP2R5B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PPP2R5B promoter
     Search Chromatin IP Primers for PPP2R5B
     RT2 qPCR Primer Assay in human, mouse, rat PPP2R5B
     Search GNC Networks for PPP2R5B
     SABiosciences PCR Arrays including human, mouse, rat PPP2R5B
     Search Tocris compounds for PPP2R5B (2A5B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PPP2R5B antibodies
     PPP2R5B proteins
     PPP2R5B lysates
     Antibodies for PPP2R5B
     See all of Abcam's Antibodies, Kits and Proteins for PPP2R5B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PPP2R5B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R5B
     SwitchGear 3'UTR luciferase reporter plasmids for PPP2R5B
     SwitchGear Promoter luciferase reporter plasmids for PPP2R5B
     ThermoFisher Antibodies for PPP2R5B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R5B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP2R5B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP2R5B
    Customized:
     lentivirus for stable overexpression of PPP2R5B
     lentivirus expression plasmids for stable overexpression of PPP2R5B
     adenovirus for overexpression of PPP2R5B
     LSBio Antibodies in human, mouse, rat for PPP2R5B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP2R5B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4