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Aliases for PPP2R5A Gene

Aliases for PPP2R5A Gene

  • Protein Phosphatase 2, Regulatory Subunit B', Alpha 2
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Alpha Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Alpha Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit B, Alpha 2 3
  • PP2A B Subunit Isoform PR61-Alpha 3 4
  • PP2A B Subunit Isoform B56-Alpha 3 4
  • PP2A B Subunit Isoform R5-Alpha 3 4
  • PP2A B Subunit Isoform B-Alpha 3 4
  • PR61alpha 3 4
  • Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform 3
  • PP2A, B Subunit, PR61 Alpha Isoform 3
  • PP2A, B Subunit, B56 Alpha Isoform 3
  • PP2A, B Subunit, R5 Alpha Isoform 3
  • PP2A, B Subunit, B Alpha Isoform 3
  • PR61A 3
  • B56A 3

External Ids for PPP2R5A Gene

Previous GeneCards Identifiers for PPP2R5A Gene

  • GC01P211138
  • GC01P208302
  • GC01P209074
  • GC01P209515
  • GC01P208847
  • GC01P210526
  • GC01P212458
  • GC01P183135

Summaries for PPP2R5A Gene

Entrez Gene Summary for PPP2R5A Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PPP2R5A Gene

PPP2R5A (Protein Phosphatase 2, Regulatory Subunit B', Alpha) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R5E.

UniProtKB/Swiss-Prot for PPP2R5A Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Wiki entry for PPP2R5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5A Gene

Genomics for PPP2R5A Gene

Regulatory Elements for PPP2R5A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP2R5A Gene

Chromosome:
1
Start:
212,285,537 bp from pter
End:
212,361,863 bp from pter
Size:
76,327 bases
Orientation:
Plus strand

Genomic View for PPP2R5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5A Gene

Proteins for PPP2R5A Gene

  • Protein details for PPP2R5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15172-2A5A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
    Protein Accession:
    Q15172
    Secondary Accessions:
    • B2R6D2
    • B7Z7L2
    • D3DT99
    • Q2NL72
    • Q5VVB2
    • Q8TBI9

    Protein attributes for PPP2R5A Gene

    Size:
    486 amino acids
    Molecular mass:
    56194 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1.

    Alternative splice isoforms for PPP2R5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5A Gene

Proteomics data for PPP2R5A Gene at MOPED

Post-translational modifications for PPP2R5A Gene

Other Protein References for PPP2R5A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PPP2R5A Gene

Domains & Families for PPP2R5A Gene

Gene Families for PPP2R5A Gene

Protein Domains for PPP2R5A Gene

Graphical View of Domain Structure for InterPro Entry

Q15172

UniProtKB/Swiss-Prot:

2A5A_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5A: view

Function for PPP2R5A Gene

Molecular function for PPP2R5A Gene

GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B56 alpha isoform,expressed in cardiac and skeletal muscle
UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Ontology (GO) - Molecular Function for PPP2R5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 7592815
GO:0008601 protein phosphatase type 2A regulator activity IEA --
GO:0019900 kinase binding IPI 21075214
genes like me logo Genes that share ontologies with PPP2R5A: view
genes like me logo Genes that share phenotypes with PPP2R5A: view

Animal Model Products

miRNA for PPP2R5A Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R5A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R5A Gene

Localization for PPP2R5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5A Gene

Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. {ECO:0000269 PubMed:16541025}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R5A Gene COMPARTMENTS Subcellular localization image for PPP2R5A gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PPP2R5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IDA 17245430
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 21075214
GO:0016020 colocalizes_with membrane IDA 15569306
genes like me logo Genes that share ontologies with PPP2R5A: view

Pathways & Interactions for PPP2R5A Gene

SuperPathways for PPP2R5A Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 S45 mutants of beta-catenin arent phosphorylated
3 Immune System
4 p70S6K Signaling
5 Cell Cycle, Mitotic
.62
genes like me logo Genes that share pathways with PPP2R5A: view

SIGNOR curated interactions for PPP2R5A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP2R5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0034047 regulation of protein phosphatase type 2A activity TAS 8703017
GO:0035307 positive regulation of protein dephosphorylation IMP 21075214
GO:0090005 negative regulation of establishment of protein localization to plasma membrane IMP 21075214
GO:0090219 negative regulation of lipid kinase activity IMP 21075214
genes like me logo Genes that share ontologies with PPP2R5A: view

Drugs & Compounds for PPP2R5A Gene

No Compound Related Data Available

Transcripts for PPP2R5A Gene

Unigene Clusters for PPP2R5A Gene

Protein phosphatase 2, regulatory subunit B, alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R5A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for PPP2R5A Gene

GeneLoc Exon Structure for
PPP2R5A
ECgene alternative splicing isoforms for
PPP2R5A

Expression for PPP2R5A Gene

mRNA expression in normal human tissues for PPP2R5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R5A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R5A Gene



SOURCE GeneReport for Unigene cluster for PPP2R5A Gene Hs.744012

mRNA Expression by UniProt/SwissProt for PPP2R5A Gene

Q15172-2A5A_HUMAN
Tissue specificity: Widely expressed with the highest expression in heart and skeletal muscle
genes like me logo Genes that share expression patterns with PPP2R5A: view

Protein tissue co-expression partners for PPP2R5A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPP2R5A Gene

Orthologs for PPP2R5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2R5A 35
  • 96.28 (n)
  • 99.14 (a)
PPP2R5A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R5A 35
  • 96.77 (n)
  • 99.5 (a)
PPP2R5A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r5a 35
  • 91.81 (n)
  • 98.5 (a)
Ppp2r5a 16
Ppp2r5a 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R5A 35
  • 99.4 (n)
  • 99.55 (a)
PPP2R5A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r5a 35
  • 90.6 (n)
  • 98.72 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R5A 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5A 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R5A 35
  • 87.97 (n)
  • 97.41 (a)
PPP2R5A 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R5A 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r5a 35
  • 81.76 (n)
  • 93.87 (a)
Str.7303 35
zebrafish
(Danio rerio)
Actinopterygii ppp2r5a 35
  • 71.82 (n)
  • 82.62 (a)
ppp2r5a 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD34343 37
  • 79 (a)
PP2A-B 37
  • 65 (a)
wdb 36
  • 66 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W08G11.4 37
  • 66 (a)
pptr-1 36
  • 58 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G21650 35
  • 56.03 (n)
  • 52.41 (a)
rice
(Oryza sativa)
Liliopsida Os08g0122000 35
  • 57.18 (n)
  • 54.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
ManyToMany
Species with no ortholog for PPP2R5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R5A Gene

ENSEMBL:
Gene Tree for PPP2R5A (if available)
TreeFam:
Gene Tree for PPP2R5A (if available)

Paralogs for PPP2R5A Gene

Paralogs for PPP2R5A Gene

(4) SIMAP similar genes for PPP2R5A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP2R5A: view

Variants for PPP2R5A Gene

Sequence variations from dbSNP and Humsavar for PPP2R5A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10019 -- 212,361,035(+) TGATA(A/T)GAGTG utr-variant-3-prime
rs14123 -- 212,361,106(+) AGATA(C/T)GGTAG utr-variant-3-prime
rs351380 -- 212,309,510(+) GCTTT(C/T)GGCGC intron-variant
rs351381 -- 212,312,265(+) tgtaa(A/T)acatt intron-variant
rs351382 -- 212,307,576(-) GTACC(A/G)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5A Gene

Variant ID Type Subtype PubMed ID
nsv873155 CNV Loss 21882294
esv27948 CNV Loss 19812545
esv2722473 CNV Deletion 23290073
esv2464712 CNV Deletion 19546169
nsv511729 CNV Loss 21212237
esv2411059 CNV Deletion 18987734
esv2722484 CNV Deletion 23290073
esv2671226 CNV Deletion 23128226
dgv7n6 CNV Loss 16902084
esv990359 CNV Deletion 20482838
esv7385 CNV Loss 19470904
esv1467950 CNV Deletion 17803354
nsv4454 CNV Insertion 18451855

Variation tolerance for PPP2R5A Gene

Residual Variation Intolerance Score: 18.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R5A Gene

HapMap Linkage Disequilibrium report
PPP2R5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5A Gene

Disorders for PPP2R5A Gene

Relevant External Links for PPP2R5A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R5A
genes like me logo Genes that share disorders with PPP2R5A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R5A Gene

Publications for PPP2R5A Gene

  1. Screening and identification of proteins interacting with nucleostemin. (PMID: 16097049) Yang H.X. … Shou C.C. (World J. Gastroenterol. 2005) 23 67
  2. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B. … Virshup D.M. (J. Biol. Chem. 1995) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 67

Products for PPP2R5A Gene

Sources for PPP2R5A Gene

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