Aliases for PPP2R4 Gene
- Protein Phosphatase 2A Regulatory Subunit 4 2 3 5
- Phosphotyrosyl Phosphatase Activator 2 3 4
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B 3 4
- Protein Phosphatase 2A Activator, Regulatory Subunit 4 2 3
- Protein Phosphatase 2A, Regulatory Subunit B (PR 53) 2 3
- PP2A Phosphatase Activator 2 3
- PTPA 3 4
External Ids for PPP2R4 Gene
Previous GeneCards Identifiers for PPP2R4 Gene
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2R4 Gene
PPP2R4 (Protein Phosphatase 2A Regulatory Subunit 4) is a Protein Coding gene. Diseases associated with PPP2R4 include tauopathy and acute leukemia of ambiguous lineage. Among its related pathways are Translation Insulin regulation of translation and DNA Damage. GO annotations related to this gene include protein homodimerization activity and receptor binding.
UniProtKB/Swiss-Prot for PPP2R4 Gene
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.