Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP2R4 Gene

Aliases for PPP2R4 Gene

  • Protein Phosphatase 2A Regulatory Subunit 4 2 3 5
  • Phosphotyrosyl Phosphatase Activator 2 3 4
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B 3 4
  • Protein Phosphatase 2A Activator, Regulatory Subunit 4 2 3
  • Protein Phosphatase 2A, Regulatory Subunit B (PR 53) 2 3
  • PP2A Phosphatase Activator 2 3
  • PTPA 3 4
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit 4 4
  • PP2A, Subunit B, PR53 Isoform 4
  • PP2A Subunit B Isoform PR53 3
  • EC 5.2.1.8 4
  • PP2A 3
  • PR53 3

External Ids for PPP2R4 Gene

Previous GeneCards Identifiers for PPP2R4 Gene

  • GC09P122987
  • GC09P123519
  • GC09P125326
  • GC09P127249
  • GC09P128952
  • GC09P130913
  • GC09P131873
  • GC09P101480

Summaries for PPP2R4 Gene

Entrez Gene Summary for PPP2R4 Gene

  • Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R4 Gene

PPP2R4 (Protein Phosphatase 2A Regulatory Subunit 4) is a Protein Coding gene. Diseases associated with PPP2R4 include Tauopathy and Acute Leukemia Of Ambiguous Lineage. Among its related pathways are CTLA4 Signaling and p70S6K Signaling. GO annotations related to this gene include protein homodimerization activity and receptor binding.

UniProtKB/Swiss-Prot for PPP2R4 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.

Gene Wiki entry for PPP2R4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R4 Gene

Genomics for PPP2R4 Gene

Regulatory Elements for PPP2R4 Gene

Enhancers for PPP2R4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP2R4 on UCSC Golden Path with GeneCards custom track

Promoters for PPP2R4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2R4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPP2R4 gene promoter:

Genomic Location for PPP2R4 Gene

Chromosome:
9
Start:
129,110,945 bp from pter
End:
129,148,946 bp from pter
Size:
38,002 bases
Orientation:
Plus strand

Genomic View for PPP2R4 Gene

Genes around PPP2R4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R4 Gene

Proteins for PPP2R4 Gene

  • Protein details for PPP2R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15257-PTPA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A activator
    Protein Accession:
    Q15257
    Secondary Accessions:
    • A2A347
    • A9IZU4
    • B4DXM4
    • Q15258
    • Q53GZ3
    • Q5TZQ2
    • Q9BUK1
    • Q9NNZ7
    • Q9NNZ8
    • Q9NNZ9

    Protein attributes for PPP2R4 Gene

    Size:
    358 amino acids
    Molecular mass:
    40668 Da
    Quaternary structure:
    • Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB (By similarity).

    Three dimensional structures from OCA and Proteopedia for PPP2R4 Gene

    Alternative splice isoforms for PPP2R4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R4 Gene

Proteomics data for PPP2R4 Gene at MOPED

Post-translational modifications for PPP2R4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PPP2R4 Gene

Domains & Families for PPP2R4 Gene

Protein Domains for PPP2R4 Gene

Graphical View of Domain Structure for InterPro Entry

Q15257

UniProtKB/Swiss-Prot:

PTPA_HUMAN :
  • Belongs to the PTPA-type PPIase family.
Family:
  • Belongs to the PTPA-type PPIase family.
genes like me logo Genes that share domains with PPP2R4: view

Function for PPP2R4 Gene

Molecular function for PPP2R4 Gene

GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B (PR53)
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.

Enzyme Numbers (IUBMB) for PPP2R4 Gene

Gene Ontology (GO) - Molecular Function for PPP2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0008160 protein tyrosine phosphatase activator activity IDA 16916641
GO:0051721 protein phosphatase 2A binding IDA 16916641
genes like me logo Genes that share ontologies with PPP2R4: view
genes like me logo Genes that share phenotypes with PPP2R4: view

Animal Model Products

miRNA for PPP2R4 Gene

miRTarBase miRNAs that target PPP2R4

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R4 Gene

Localization for PPP2R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R4 Gene COMPARTMENTS Subcellular localization image for PPP2R4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 3
endoplasmic reticulum 2
mitochondrion 2
plasma membrane 2
endosome 1
golgi apparatus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PPP2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17333320
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PPP2R4: view

Pathways & Interactions for PPP2R4 Gene

genes like me logo Genes that share pathways with PPP2R4: view

SIGNOR curated interactions for PPP2R4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PPP2R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034047 regulation of protein phosphatase type 2A activity TAS 10318862
GO:0035307 positive regulation of protein dephosphorylation IDA 16916641
GO:0043666 regulation of phosphoprotein phosphatase activity IDA 16916641
genes like me logo Genes that share ontologies with PPP2R4: view

Drugs & Compounds for PPP2R4 Gene

(50) Drugs for PPP2R4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(49) Additional Compounds for PPP2R4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPP2R4: view

Transcripts for PPP2R4 Gene

Unigene Clusters for PPP2R4 Gene

Protein phosphatase 2A activator, regulatory subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6: - - - - - -
SP7: - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - -
SP11:
SP12:
SP13: - - - - -
SP14: - - - - - - -
SP15: - - - -
SP16: - - - - - - - - - - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c · 19d · 19e · 19f · 19g · 19h ^ 20
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - -
SP13:
SP14:
SP15:
SP16: - - - - - - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - - - - -
SP20: - - - - - - - - - - -
SP21: - - - - - - -
SP22: - - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - -
SP25: - - - - -
SP26: - - - -

Relevant External Links for PPP2R4 Gene

GeneLoc Exon Structure for
PPP2R4
ECgene alternative splicing isoforms for
PPP2R4

Expression for PPP2R4 Gene

mRNA expression in normal human tissues for PPP2R4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R4 Gene



SOURCE GeneReport for Unigene cluster for PPP2R4 Gene Hs.400740

mRNA Expression by UniProt/SwissProt for PPP2R4 Gene

Q15257-PTPA_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PPP2R4: view

Protein tissue co-expression partners for PPP2R4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PPP2R4 Gene

Orthologs for PPP2R4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2R4 35
  • 92.88 (n)
  • 96.9 (a)
PPP2R4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R4 35
  • 92.75 (n)
  • 97.83 (a)
PPP2R4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r4 35
  • 89.89 (n)
  • 96.28 (a)
Ppp2r4 16
Ppp2r4 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R4 35
  • 99.59 (n)
  • 100 (a)
PPP2R4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r4 35
  • 89.47 (n)
  • 95.05 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R4 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R4 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R4 35
  • 80.89 (n)
  • 90.34 (a)
PPP2R4 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R4 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r4 35
  • 76.29 (n)
  • 84.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8828 35
zebrafish
(Danio rerio)
Actinopterygii ppp2r4 35
  • 73.65 (n)
  • 82.19 (a)
wufc23d07 35
ppp2r4 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8890 35
fruit fly
(Drosophila melanogaster)
Insecta CG2104 37
  • 31 (a)
CG8509 37
  • 31 (a)
Ptpa 37
  • 49 (a)
Ptpa 35
  • 56.76 (n)
  • 48.99 (a)
CG2104 36
  • 23 (a)
OneToMany
CG8509 36
  • 22 (a)
OneToMany
Ptpa 36
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008652 35
  • 56.44 (n)
  • 49.83 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.20 35
  • 51.63 (n)
  • 46.8 (a)
Y71H2AM.20 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR139C 35
  • 53.79 (n)
  • 42.07 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11187g 35
  • 47.09 (n)
  • 38.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRD2 35
  • 48.46 (n)
  • 38.23 (a)
RRD1 36
  • 33 (a)
OneToOne
RRD2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G08960 35
  • 51.36 (n)
  • 45.92 (a)
soybean
(Glycine max)
eudicotyledons Gma.5058 35
rice
(Oryza sativa)
Liliopsida Os06g0219800 35
  • 54.96 (n)
  • 47.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6463 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03269 35
  • 51.28 (n)
  • 40.8 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1782.05 35
  • 45.5 (n)
  • 41.22 (a)
Species with no ortholog for PPP2R4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R4 Gene

ENSEMBL:
Gene Tree for PPP2R4 (if available)
TreeFam:
Gene Tree for PPP2R4 (if available)

Paralogs for PPP2R4 Gene

genes like me logo Genes that share paralogs with PPP2R4: view

No data available for Paralogs for PPP2R4 Gene

Variants for PPP2R4 Gene

Sequence variations from dbSNP and Humsavar for PPP2R4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17481693 - 129,120,564(+) AAAAA(A/G)GGAGA reference, missense, utr-variant-5-prime
rs4836639 - 129,134,852(+) GCTCC(A/G)GGTGG reference, missense
rs2480452 - 129,147,457(-) AGCCC(A/G)ACGTG reference, missense, utr-variant-3-prime
rs713218 -- 129,138,491(-) AACAC(C/G)TCCCT intron-variant
rs713219 -- 129,138,641(-) CTAGG(A/G)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R4 Gene

Variant ID Type Subtype PubMed ID
nsv831729 CNV Loss 17160897
nsv509323 CNV Insertion 20534489
nsv818725 CNV Gain 17921354
nsv893909 CNV Loss 21882294

Variation tolerance for PPP2R4 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP2R4 Gene

Disorders for PPP2R4 Gene

MalaCards: The human disease database

(9) MalaCards diseases for PPP2R4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tauopathy
  • tauopathies
acute leukemia of ambiguous lineage
  • acute biphenotypic leukemia
fragile x syndrome
  • fragile x mental retardation syndrome
apical myocardial infarction
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP2R4

Genetic Association Database (GAD)
PPP2R4
Human Genome Epidemiology (HuGE) Navigator
PPP2R4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R4
genes like me logo Genes that share disorders with PPP2R4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R4 Gene

Publications for PPP2R4 Gene

  1. Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. (PMID: 8530035) Van Hoof C. … Goris J. (Genomics 1995) 2 3 4 23 67
  2. The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. (PMID: 16380387) Jordens J. … Van Hoof C. (J. Biol. Chem. 2006) 2 3 23
  3. Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. (PMID: 20306465) Yoon B.S. … You S. (Stem Cells 2010) 3 23
  4. PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. (PMID: 20308788) Qian W. … Liu F. (J. Alzheimers Dis. 2010) 3 23
  5. Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. (PMID: 19234487) Samanta A.K. … Arlinghaus R.B. (Oncogene 2009) 3 23

Products for PPP2R4 Gene

Sources for PPP2R4 Gene

Content