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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP2R4 Gene

protein-coding   GIFtS: 67
GCID: GC09P131873

Protein Phosphatase 2A Activator, Regulatory Subunit 4

(Previous names: protein phosphatase 2A, regulatory subunit B' (PR 53))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 2A Activator, Regulatory Subunit 41 2     PR532
Phosphotyrosyl Phosphatase Activator1 2 3     PP2A Subunit B' Isoform PR532
PTPA2 3 5     Serine/Threonine-Protein Phosphatase 2A Activator2
Protein Phosphatase 2A, Regulatory Subunit B' (PR 53)1 2     EC 5.2.1.83
PP2A Phosphatase Activator1 2     PP2A, Subunit B', PR53 Isoform3
Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'2 3     Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit 43
PP2A2     

External Ids:    HGNC: 93081   Entrez Gene: 55242   Ensembl: ENSG000001193837   OMIM: 6007565   UniProtKB: Q152573   

Export aliases for PPP2R4 gene to outside databases

Previous GC identifers: GC09P122987 GC09P123519 GC09P125326 GC09P127249 GC09P128952 GC09P130913 GC09P101480


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R4 Gene:
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of
cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural
subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set
of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory
subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product
of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the
dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R4 Gene: 
PPP2R4 (protein phosphatase 2A activator, regulatory subunit 4) is a protein-coding gene. Diseases associated with PPP2R4 include chromosome 5q deletion, and acute undifferentiated leukemia, and among its related super-pathways are Renin-Angiotensin Pathway and Beta-Adrenergic Signaling. GO annotations related to this gene include protein homodimerization activity and receptor binding.

UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A)
modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic
subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase
methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the
variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in
vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex.
Is involved in apoptosis; the function appears to be independent from PP2A

Gene Wiki entry for PPP2R4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP2R4 gene promoter:
         AP-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PPP2R4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP2R4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

PPP2R4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131873:  view genomic region     (about GC identifiers)

Start:
131,873,228 bp from pter      End:
131,911,225 bp from pter
Size:
37,998 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A activator  
Size: 358 amino acids; 40668 Da
Subunit: Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit
C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB (By similarity)
Subcellular location: Cytoplasm. Nucleus
4 PDB 3D structures from and Proteopedia for PPP2R4:
2G62 (3D)        2HV6 (3D)        2HV7 (3D)        2IXM (3D)    
Secondary accessions: A2A347 A9IZU4 B4DXM4 Q15258 Q53GZ3 Q5TZQ2 Q9BUK1 Q9NNZ7 Q9NNZ8 Q9NNZ9
Alternative splicing: 4 isoforms:  Q15257-1   Q15257-2   Q15257-3   Q15257-4   

Explore the universe of human proteins at neXtProt for PPP2R4: NX_Q15257

Explore proteomics data for PPP2R4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15257

  • PPP2R4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP2R4 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001180326.1  NP_001258761.1  NP_066954.2  NP_821067.1  NP_821068.1  NP_821070.1  

    ENSEMBL proteins: 
     ENSP00000351885   ENSP00000395499   ENSP00000377036   ENSP00000335200   ENSP00000337412  
     ENSP00000406997   ENSP00000347109   ENSP00000399069   ENSP00000403542   ENSP00000393092  
     ENSP00000400314   ENSP00000393796   ENSP00000396660   ENSP00000405100   ENSP00000408316  
     ENSP00000389312   ENSP00000408726   ENSP00000416522   ENSP00000393196   ENSP00000394001  
     ENSP00000416661   ENSP00000387726   ENSP00000411604   ENSP00000337448   ENSP00000349726  
     ENSP00000394338   ENSP00000437306  

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    Cloud-Clone Corp. Proteins for PPP2R4 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex TAS10318862
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA17333320
    GO:0034704calcium channel complex IDA10830164

    PPP2R4 for ontologies           About GeneDecksing



    PPP2R4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    1 InterPro protein domain:
     IPR004327 Phstyr_phstse_ac

    Graphical View of Domain Structure for InterPro Entry Q15257

    ProtoNet protein and cluster: Q15257

    1 Blocks protein domain: IPB004327 Phosphotyrosyl phosphatase activator

    UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257
    Similarity: Belongs to the PTPA-type PPIase family


    PPP2R4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPA_HUMAN, Q15257
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A)
    modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic
    subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase
    methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the
    variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in
    vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex.
    Is involved in apoptosis; the function appears to be independent from PP2A
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Genatlas biochemistry entry for PPP2R4:
    protein phosphatase 2A,regulatory subunit B' (PR53)

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0005102receptor binding IPI10830164
    GO:0005524ATP binding IDA16916641
    GO:0008160protein tyrosine phosphatase activator activity IDA16916641
    GO:0008601protein phosphatase type 2A regulator activity TAS10318862
         
    PPP2R4 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PPP2R4:
     Apoptosis resistance  Decreased focal adhesion (FA)   Increased Akt phosphorylation   Increased cell death HMECs cel 
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP2R4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPP2R4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP2R4:
    hsa-mir-30a (MIRT005188)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP2R4
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2R4 (see all 20):
    hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-764 hsa-miR-218 hsa-miR-9 hsa-miR-661 hsa-miR-629* hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP2R4 About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    2Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37
    CDK5 Pathway0.36
    Erythropoietin Pathway0.37
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    4Rho Family GTPases
    ERK Signaling0.61
    ILK Signaling0.49
    5Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cell Cycle Control by BTG Proteins0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PPP2R4
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Signal transduction PKA signaling

    5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2R4 (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    1 Cell Signaling Technology (CST) Pathway for PPP2R4
        Phosphatases

    4 GeneGo (Thomson Reuters) Pathways for PPP2R4
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/6 BioSystems Pathways for PPP2R4 (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway
    Interleukin-11 Signaling Pathway
    p53 pathway



    PPP2R4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP2R4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for PPP2R4 (Q152572, 3 ENSP000003518854) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKT1P317492, 3, ENSP000002702024MINT-8203949 I2D: score=1 STRING: ENSP00000270202
    BCL2P104153, ENSP000003296234I2D: score=2 STRING: ENSP00000329623
    CCNG2Q165893, ENSP000003157434I2D: score=2 STRING: ENSP00000315743
    CCT7Q998323, ENSP000002580914I2D: score=2 STRING: ENSP00000258091
    CCT8P509903, ENSP000002867884I2D: score=2 STRING: ENSP00000286788
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0006200ATP catabolic process IDA16916641
    GO:0006457protein folding IEA--
    GO:0030472mitotic spindle organization in nucleus IBA--
    GO:0032515negative regulation of phosphoprotein phosphatase activity IDA16916641

    PPP2R4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP2R4 for compounds           About GeneDecksing

    EMD Millipore small molecules for PPP2R4:
    Small Molecule - inhibitor
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    10/99 Novoseek inferred chemical compound relationships for PPP2R4 gene (see all 99)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    okadaic acid 95.5 477 19673077 (4), 7702557 (4), 8538625 (3), 19013124 (3) (see all 99)
    calyculin a 90.6 84 7702557 (3), 9153244 (3), 15972258 (2), 8750856 (2) (see all 51)
    fostriecin 89.6 41 19592665 (3), 15972258 (2), 16845173 (2), 17177422 (2) (see all 19)
    threonine 89.1 224 12952889 (3), 14710095 (2), 14585537 (2), 1328040 (2) (see all 99)
    tautomycin 87.9 31 7702557 (3), 10493981 (2), 9153244 (2), 10926829 (2) (see all 16)
    serine 84 228 11593413 (3), 12952889 (2), 14710095 (2), 18940248 (2) (see all 99)
    cytostatin 81.1 11 17177422 (3), 19592665 (3), 10559474 (2), 12586599 (1)
    cantharidin 78.9 25 11677131 (2), 8397101 (2), 10937725 (2), 12003183 (2) (see all 15)
    microcystin-lr 78.4 40 10222000 (3), 17369605 (3), 18214937 (3), 2162782 (3) (see all 17)
    sultriecin 73.4 1 17177422 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP2R4 / PTPA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PPP2R4 gene (7 alternative transcripts): 
    NM_001193397.1  NM_001271832.1  NM_021131.4  NM_178000.2  NM_178001.2  NM_178003.2  NM_178002.1  

    Unigene Cluster for PPP2R4:

    Protein phosphatase 2A activator, regulatory subunit 4
    Hs.400740  [show with all ESTs]
    Unigene Representative Sequence: NM_178001
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000358994(uc004bxl.2) ENST00000455292 ENST00000393370(uc010myr.2 uc004bxn.2 uc004bxo.2 uc011mbp.2 uc010mys.2)
    ENST00000348141 ENST00000347048(uc004bxp.3 uc004bxq.3) ENST00000445241
    ENST00000355007 ENST00000414331 ENST00000417728 ENST00000453358 ENST00000417504
    ENST00000440346 ENST00000455240 ENST00000411917 ENST00000423100 ENST00000436883
    ENST00000414510 ENST00000432124
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK097317.1 AK222788.1 AK293296.1 AK297202.1 AK302043.1 AK302897.1 AK307424.1 AK310328.1 
    AK310543.1 BC002545.2 BC010497.1 BC011605.2 BC020581.1 BT020119.1 CR749810.1 X73478.1 

    24/40 DOTS entries (see all 40):

    DT.100880609  DT.40270850  DT.95273217  DT.100880591  DT.100799037  DT.449928  DT.100880608  DT.100038763 
    DT.95225093  DT.100880598  DT.95273213  DT.100880588  DT.100880604  DT.121146259  DT.75139096  DT.121146302 
    DT.100038764  DT.102842989  DT.99981266  DT.121146349  DT.100758845  DT.102842992  DT.102842993  DT.121146369 

    24/633 AceView cDNA sequences (see all 633):

    BU902471 CR617712 BX393844 BM927249 CB136313 BP366885 BG107502 BG107573 
    BX957076 AU131509 BE901292 AA326397 BQ426122 BM827443 NM_178001 AI903648 
    AA323276 BQ069151 BM833792 CR620812 AA351011 BQ072982 AU279725 BE549087 

    GeneLoc Exon Structure

    5/26 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R4 (see all 26)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^
    SP1:        -     -     -     -           -                 -                 -                                                                                 
    SP2:                                      -                 -                 -                                                                                 
    SP3:                                      -                 -     -     -     -                                                                                 
    SP4:                                      -                                   -                                                                                 
    SP5:                                      -                 -                                                                                                   

    ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c · 19d · 19e · 19f · 19g · 19h ^ 20
    SP1:  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -                                                         
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for PPP2R4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP2R4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTCCAGA
    PPP2R4 Expression
    About this image


    See PPP2R4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP2R4

    SOURCE GeneReport for Unigene cluster: Hs.400740

    UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including PPP2R4: 
              mTOR Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R4 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r41 , 5 protein phosphatase 2A, regulatory subunit B (PR 53)1, 5 89.89(n)1
    96.28(a)1
      2 (21.71 cM)5
    1108541  NM_138748.51  NP_620087.31 
     304160395 
    chicken
    (Gallus gallus)
    Aves PPP2R41 protein phosphatase 2A activator, regulatory subunit more 80.89(n)
    90.34(a)
      426329  NM_001031371.1  NP_001026542.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R46
    protein phosphatase 2A activator, regulatory subun...
    74(a)
    1 ↔ 1
    GL344059.1(29529-44371)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88282 Xenopus laevis transcribed sequence with moderate similarity more 78.72(n)    BU908069.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc23d072 wufc23d07 78.52(n)   324275  CK028180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptpa1 , 3 protein tyrosine phosphatase activator3
    Phosphotyrosyl phosphatase activator1
    49(a)
    (best of 3)3
    56.76(n)1
    48.99(a)1
      23F13
    335551  NM_078742.21  NP_523466.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.201 Protein Y71H2AM.20 51.69(n)
    46.96(a)
      175395  NM_065216.4  NP_497617.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRD2(YPL152W)4
    RRD21
    Activator of the phosphotyrosyl phosphatase activity more4
    Rrd2p1
    48.01(n)1
    38.23(a)1
      16(265028-266104)4
    8559511, 4  NP_015173.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G089601 phosphotyrosyl phosphatase activator (PTPA) family more 50.92(n)
    44.95(a)
      826474  NM_116965.2  NP_567342.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02198001 hypothetical protein 54.96(n)
    47.49(a)
      4340511  NM_001063700.1  NP_001057165.1 


    ENSEMBL Gene Tree for PPP2R4 (if available)
    TreeFam Gene Tree for PPP2R4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP2R4 gene
    1 SIMAP similar gene for PPP2R4 using alignment to 16 protein entries:     PTPA_HUMAN (see all proteins):
    DKFZp781M17165

    PPP2R4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1056 SNPs in PPP2R4 are shown (see all 1056)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005796271,2
    C--101488573(+) AGAAAA/GAGAAA 6 -- int10--------
    rs106844651,2
    C--101493181(+) AACTTTT/-GAAAT 6 -- int11Minor allele frequency- -:0.50NA 2
    rs748485871,2
    --101500287(+) TAAACT/AGTGCT 6 -- int11Minor allele frequency- A:0.00CSA 1
    rs590679261,2
    C--131875225(+) CCCCC-/C/CA  
            
    AAAAA
    6 -- int11NA 2
    rs1125574051,2
    F--131875891(+) TCAAAG/ATACAA 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs713836301,2
    C--131878630(+) GCTAAT/-TTTTT 6 -- int11Minor allele frequency- -:0.00NA 2
    rs120004211,2
    C,F,H--131878913(+) cccgcC/Ttcggc 6 -- int17Minor allele frequency- T:0.00NS EA NA 424
    rs784114981,2
    C--131880344(+) TTTTTC/TCCCCC 6 -- int10--------
    rs107123191,2
    C--131881093(+) CCAGC-/TTTTTT 6 -- int1 trp30--------
    rs599789301,2
    C--131881093(+) TTTTTT/-GATGC 6 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for PPP2R4 (131873228 - 131911225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP2R4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509323CNV Insertion20534489
    nsv831729CNV Loss17160897
    nsv893909CNV Loss21882294
    nsv818725CNV Gain17921354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600756    OMIM disorders: --

    20/61 diseases for PPP2R4 (see all 61):    About MalaCards
    chromosome 5q deletion    acute undifferentiated leukemia    tauopathy    cardiovascular disease risk factor )
    fragile x syndrome    cerebral cavernous malformations 3    ataxia telangiectasia    breast disease
    familial adenomatous polyposis    brain disease    acute lymphocytic leukemia    cerebral cavernous malformation
    cholera    cavernous malformation    ichthyosis    cytomegalovirus infection
    malignant mesothelioma    gout    hepatitis c    retinoblastoma

    2 diseases from the University of Copenhagen DISEASES database for PPP2R4:
    Alzheimer's disease     Cancer

    PPP2R4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/52 Novoseek inferred disease relationships for PPP2R4 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paired helical filament 61.3 2 15616638 (1), 15475565 (1)
    neurofibrillary tangles 52.5 7 12937125 (2), 7946342 (1), 17662457 (1), 18208556 (1) (see all 5)
    tauopathies 51.1 1 18484086 (1)
    alzheimers disease 43.8 18 17662457 (2), 19278841 (2), 17086192 (1), 7812792 (1) (see all 16)
    acute undifferentiated leukemia 43.5 2 11231286 (1), 15703833 (1)
    tumors 38.3 96 18246411 (4), 11448528 (3), 15016329 (3), 19184590 (3) (see all 56)
    retinoblastoma 33 1 10542219 (1)
    blast crisis 26.2 4 16286244 (2), 16953242 (1)
    cancer 26.1 40 16477370 (3), 18213449 (2), 16299534 (2), 17313179 (2) (see all 28)
    neurodegenerative diseases 25.1 4 19940183 (1), 20110589 (1), 17303700 (1), 12937125 (1)

    Genetic Association Database (GAD): PPP2R4
    Human Genome Epidemiology (HuGE) Navigator: PPP2R4 (1 document)

    Export disorders for PPP2R4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP2R4 gene, integrated from 9 sources (see all 752):
    (articles sorted by number of sources associating them with PPP2R4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. (PubMed id 8530035)1, 2, 3, 9 Van Hoof C.... Goris J. (1995)
    2. Structure and mechanism of the phosphotyrosyl phosphatase activator. (PubMed id 16916641)1, 2, 9 Chao Y.... Shi Y. (2006)
    3. The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. (PubMed id 16782712)1, 2, 9 Magnusdottir A.... Nordlund P. (2006)
    4. Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene. (PubMed id 10880964)1, 2, 9 Janssens V....Goris J. (2000)
    5. Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A. (PubMed id 8195217)1, 2, 9 Cayla X.... Goris J. (1994)
    6. Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis. (PubMed id 17333320)1, 2 Azam S....Ramotar D. (2007)
    7. Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. (PubMed id 16885030)1, 2 Leulliot N....Goris J. (2006)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. (PubMed id 16380387)1, 9 Jordens J....Van Hoof C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5524 HGNC: 9308 AceView: PPP2R4 Ensembl:ENSG00000119383 euGenes: HUgn5524
    ECgene: PPP2R4 H-InvDB: PPP2R4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP2R4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP2R4 gene:
    Search GeneIP for patents involving PPP2R4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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