Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PPP2R4 Gene

protein-coding   GIFtS: 67
GCID: GC09P131873

Protein Phosphatase 2A Activator, Regulatory Subunit 4

(Previous names: protein phosphatase 2A, regulatory subunit B' (PR 53))
  See PPP2R4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Phosphatase 2A Activator, Regulatory Subunit 41 2     PR532
Phosphotyrosyl Phosphatase Activator1 2 3     PP2A Subunit B' Isoform PR532
PTPA2 3 5     Serine/Threonine-Protein Phosphatase 2A Activator2
Protein Phosphatase 2A, Regulatory Subunit B' (PR 53)1 2     EC 5.2.1.83
PP2A Phosphatase Activator1 2     PP2A, Subunit B', PR53 Isoform3
Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'2 3     Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit 43
PP2A2     

External Ids:    HGNC: 93081   Entrez Gene: 55242   Ensembl: ENSG000001193837   OMIM: 6007565   UniProtKB: Q152573   

Export aliases for PPP2R4 gene to outside databases

Previous GC identifers: GC09P122987 GC09P123519 GC09P125326 GC09P127249 GC09P128952 GC09P130913 GC09P101480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PPP2R4 Gene:
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of
cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural
subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set
of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory
subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product
of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the
dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R4 Gene:
PPP2R4 (protein phosphatase 2A activator, regulatory subunit 4) is a protein-coding gene. Diseases associated with PPP2R4 include chromosome 5q deletion, and hypersomnia. GO annotations related to this gene include protein homodimerization activity and receptor binding.

UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A)
modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic
subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase
methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the
variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in
vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex.
Is involved in apoptosis; the function appears to be independent from PP2A

Gene Wiki entry for PPP2R4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R4 gene promoter:
         AP-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PPP2R4 promoter sequence
   Search Chromatin IP Primers for PPP2R4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

PPP2R4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131873:  view genomic region     (about GC identifiers)

Start:
131,873,228 bp from pter      End:
131,911,225 bp from pter
Size:
37,998 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A activator  
Size: 358 amino acids; 40668 Da
Subunit: Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit
C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB (By similarity)
5 PDB 3D structures from and Proteopedia for PPP2R4:
2G62 (3D)        2HV6 (3D)        2HV7 (3D)        2IXM (3D)        4LAC (3D)    
Secondary accessions: A2A347 A9IZU4 B4DXM4 Q15258 Q53GZ3 Q5TZQ2 Q9BUK1 Q9NNZ7 Q9NNZ8 Q9NNZ9
Alternative splicing: 4 isoforms:  Q15257-1   Q15257-2   Q15257-3   Q15257-4   

Explore the universe of human proteins at neXtProt for PPP2R4: NX_Q15257

Explore proteomics data for PPP2R4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP2R4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001180326.1  NP_001258761.1  NP_066954.2  NP_821067.1  NP_821068.1  NP_821070.1  

    ENSEMBL proteins: 
     ENSP00000351885   ENSP00000395499   ENSP00000377036   ENSP00000335200   ENSP00000337412  
     ENSP00000406997   ENSP00000347109   ENSP00000399069   ENSP00000403542   ENSP00000393092  
     ENSP00000400314   ENSP00000393796   ENSP00000396660   ENSP00000405100   ENSP00000408316  
     ENSP00000389312   ENSP00000408726   ENSP00000416522   ENSP00000393196   ENSP00000394001  
     ENSP00000416661   ENSP00000387726   ENSP00000411604   ENSP00000337448   ENSP00000349726  
     ENSP00000394338   ENSP00000437306  

    PPP2R4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PPP2R4
    OriGene Protein Over-expression Lysate for PPP2R4
    OriGene MassSpec for PPP2R4
    OriGene Custom Protein Services for PPP2R4
    GenScript Custom Purified and Recombinant Proteins Services for PPP2R4
    Novus Biologicals PPP2R4 Proteins
    Novus Biologicals PPP2R4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPP2R4

     
    Search eBioscience for Proteins for PPP2R4 

    PPP2R4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2R4
    R&D Systems Antibodies for PPP2R4
    OriGene Antibodies for PPP2R4
    OriGene Custom Antibody Services for PPP2R4
    Novus Biologicals PPP2R4 Antibodies
    Abcam antibodies for PPP2R4
    Cloud-Clone Corp. Antibodies for PPP2R4
    ThermoFisher Antibody for PPP2R4
    LSBio Antibodies in human, mouse, rat for PPP2R4

    PPP2R4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP2R4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP2R4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPP2R4
    Cloud-Clone Corp. CLIAs for PPP2R4
    Search eBioscience for ELISAs for PPP2R4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    1 InterPro protein domain:
     IPR004327 Phstyr_phstse_ac

    Graphical View of Domain Structure for InterPro Entry Q15257

    ProtoNet protein and cluster: Q15257

    1 Blocks protein domain: IPB004327 Phosphotyrosyl phosphatase activator

    UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257
    Similarity: Belongs to the PTPA-type PPIase family


    Find genes that share domains with PPP2R4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPA_HUMAN, Q15257
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A)
    modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic
    subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase
    methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the
    variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in
    vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex.
    Is involved in apoptosis; the function appears to be independent from PP2A
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Genatlas biochemistry entry for PPP2R4:
    protein phosphatase 2A,regulatory subunit B' (PR53)

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0005102receptor binding IPI10830164
    GO:0005524ATP binding IDA16916641
    GO:0008160protein tyrosine phosphatase activator activity IDA16916641
    GO:0008601protein phosphatase type 2A regulator activity TAS10318862
         
    Find genes that share ontologies with PPP2R4           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PPP2R4:
     Apoptosis resistance  Decreased focal adhesion (FA)   Increased Akt phosphorylation   Increased cell death HMECs cel 
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP2R4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R4

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP2R4:
    hsa-mir-326 (MIRT043628), hsa-mir-30a-5p (MIRT005188)

    Block miRNA regulation of human, mouse, rat PPP2R4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R4 (see all 20):
    hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-764 hsa-miR-218 hsa-miR-9 hsa-miR-661 hsa-miR-629* hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP2R4
    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP2R4

    Clone
    Products:
         
    OriGene clones in human, mouse for PPP2R4 (see all 26)
    OriGene ORF clones in mouse, rat for PPP2R4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PPP2R4 (NM_178003)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP2R4
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPP2R4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PTPA_HUMAN, Q15257: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    plasma membrane2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex TAS10318862
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA17333320
    GO:0034704calcium channel complex IDA10830164

    Find genes that share ontologies with PPP2R4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PPP2R4 About   (see all 29)  
    See pathways by source

    SuperPathContained pathways About
    1p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    CDK5 Pathway0.36
    Erythropoietin Pathway0.37
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    4ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    5Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cell Cycle Control by BTG Proteins0.36


    Find genes that share SuperPaths with PPP2R4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R4 (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    1 Cell Signaling Technology (CST) Pathway for PPP2R4
        Phosphatases

    4 GeneGo (Thomson Reuters) Pathways for PPP2R4
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PPP2R4 (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway
    Interleukin-11 Signaling Pathway
    p53 pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including PPP2R4: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP2R4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R4 (Q152572, 3 ENSP000003518854) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKT1P317492, 3, ENSP000002702024MINT-8203949 I2D: score=1 STRING: ENSP00000270202
    BCL2P104153, ENSP000003296234I2D: score=2 STRING: ENSP00000329623
    CCNG2Q165893, ENSP000003157434I2D: score=2 STRING: ENSP00000315743
    CCT6AP402273, ENSP000002756034I2D: score=2 STRING: ENSP00000275603
    TCP1P179873, ENSP000003173344I2D: score=2 STRING: ENSP00000317334
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0006200ATP catabolic process IDA16916641
    GO:0006457protein folding IEA--
    GO:0030472mitotic spindle organization in nucleus IBA--
    GO:0032515negative regulation of phosphoprotein phosphatase activity IDA16916641

    Find genes that share ontologies with PPP2R4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP2R4 (PTPA)

    Selected Novoseek inferred chemical compound relationships for PPP2R4 gene (see all 99)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    okadaic acid 95.5 477 19673077 (4), 7702557 (4), 8538625 (3), 19013124 (3) (see all 99)
    calyculin a 90.6 84 7702557 (3), 9153244 (3), 15972258 (2), 8750856 (2) (see all 51)
    fostriecin 89.6 41 19592665 (3), 15972258 (2), 16845173 (2), 17177422 (2) (see all 19)
    threonine 89.1 224 12952889 (3), 14710095 (2), 14585537 (2), 1328040 (2) (see all 99)
    tautomycin 87.9 31 7702557 (3), 10493981 (2), 9153244 (2), 10926829 (2) (see all 16)
    serine 84 228 11593413 (3), 12952889 (2), 14710095 (2), 18940248 (2) (see all 99)
    cytostatin 81.1 11 17177422 (3), 19592665 (3), 10559474 (2), 12586599 (1)
    cantharidin 78.9 25 11677131 (2), 8397101 (2), 10937725 (2), 12003183 (2) (see all 15)
    microcystin-lr 78.4 40 10222000 (3), 17369605 (3), 18214937 (3), 2162782 (3) (see all 17)
    sultriecin 73.4 1 17177422 (1)



    Find genes that share compounds with PPP2R4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PPP2R4 gene (7 alternative transcripts): 
    NM_001193397.1  NM_001271832.1  NM_021131.4  NM_178000.2  NM_178001.2  NM_178003.2  NM_178002.1  

    Unigene Cluster for PPP2R4:

    Protein phosphatase 2A activator, regulatory subunit 4
    Hs.400740  [show with all ESTs]
    Unigene Representative Sequence: NM_178001
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000358994(uc004bxl.2) ENST00000455292 ENST00000393370(uc010myr.2 uc004bxn.2 uc004bxo.2 uc011mbp.2 uc010mys.2)
    ENST00000348141 ENST00000347048(uc004bxp.3 uc004bxq.3) ENST00000445241
    ENST00000355007 ENST00000414331 ENST00000417728 ENST00000453358 ENST00000417504
    ENST00000440346 ENST00000455240 ENST00000411917 ENST00000423100 ENST00000436883
    ENST00000414510 ENST00000432124
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPP2R4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R4 (see all 20):
    hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-764 hsa-miR-218 hsa-miR-9 hsa-miR-661 hsa-miR-629* hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPP2R4
    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R4
    Clone
    Products:
         
    OriGene clones in human, mouse for PPP2R4 (see all 26)
    OriGene ORF clones in mouse, rat for PPP2R4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PPP2R4 (NM_178003)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPP2R4
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R4
      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R4
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R4

    Additional mRNA sequence: 

    AK097317.1 AK222788.1 AK293296.1 AK297202.1 AK302043.1 AK302897.1 AK307424.1 AK310328.1 
    AK310543.1 BC002545.2 BC010497.1 BC011605.2 BC020581.1 BT020119.1 CR749810.1 X73478.1 

    Selected DOTS entries (see all 40):

    DT.100880609  DT.40270850  DT.95273217  DT.100880591  DT.100799037  DT.449928  DT.100880608  DT.100038763 
    DT.95225093  DT.100880598  DT.95273213  DT.100880588  DT.100880604  DT.121146259  DT.75139096  DT.121146302 
    DT.100038764  DT.102842989  DT.99981266  DT.121146349  DT.100758845  DT.102842992  DT.102842993  DT.121146369 

    Selected AceView cDNA sequences (see all 633):

    NM_178000 CR597906 BM817672 AA323276 BG107502 BI858178 AU131916 AU141961 
    BM787847 BF970472 AU125210 AI903648 BM856040 BM927249 BQ894460 BU902471 
    BQ069151 NM_021131 CR620812 CR617712 BE549087 CB136313 AU279725 BQ876807 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R4 (see all 26)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^
    SP1:        -     -     -     -           -                 -                 -                                                                                 
    SP2:                                      -                 -                 -                                                                                 
    SP3:                                      -                 -     -     -     -                                                                                 
    SP4:                                      -                                   -                                                                                 
    SP5:                                      -                 -                                                                                                   

    ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c · 19d · 19e · 19f · 19g · 19h ^ 20
    SP1:  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -                                                         
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for PPP2R4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PPP2R4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTCCAGA
    PPP2R4 Expression
    About this image


    PPP2R4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    PPP2R4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.400740

    UniProtKB/Swiss-Prot: PTPA_HUMAN, Q15257
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including PPP2R4: 
              mTOR Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPP2R4
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R4
    QuantiTect SYBR Green Assays in human, mouse, rat PPP2R4
    QuantiFast Probe-based Assays in human, mouse, rat PPP2R4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R4 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r41 , 5 protein phosphatase 2A, regulatory subunit B (PR 53)5
    protein phosphatase 2A activator, regulatory subunit more1
    89.89(n)1
    96.28(a)1
      2 (21.71 cM)5
    1108541  NM_138748.51  NP_620087.31 
     304160395 
    chicken
    (Gallus gallus)
    Aves PPP2R41 protein phosphatase 2A activator, regulatory subunit more 80.89(n)
    90.34(a)
      426329  NM_001031371.1  NP_001026542.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R46
    protein phosphatase 2A activator, regulatory subun...
    80(a)
    1 ↔ 1
    GL344059.1(29529-44371)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88282 Xenopus laevis transcribed sequence with moderate similarity more 78.72(n)    BU908069.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc23d072 wufc23d07 78.52(n)   324275  CK028180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptpa1 , 3 protein tyrosine phosphatase activator3
    Phosphotyrosyl phosphatase activator1
    49(a)
    (best of 3)3
    56.76(n)1
    48.99(a)1
      23F13
    335551  NM_078742.31  NP_523466.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.201 Y71H2AM.20 51.63(n)
    46.8(a)
      175395  NM_065216.5  NP_497617.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRD2(YPL152W)4
    RRD21
    Activator of the phosphotyrosyl phosphatase activity more4
    RRD21
    48.46(n)1
    38.23(a)1
      16(265028-266104)4
    8559511, 4  NP_015173.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G089601 AT4G08960 51.36(n)
    45.92(a)
      826474  NM_116965.2  NP_567342.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02198001 Os06g0219800 54.96(n)
    47.49(a)
      4340511  NM_001063700.1  NP_001057165.1 


    ENSEMBL Gene Tree for PPP2R4 (if available)
    TreeFam Gene Tree for PPP2R4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PPP2R4 gene
    1 SIMAP similar gene for PPP2R4 using alignment to 16 protein entries:     PTPA_HUMAN (see all proteins):
    DKFZp781M17165

    Find genes that share paralogs with PPP2R4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PPP2R4 (see all 1056)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005796271,2
    C--101488573(+) AGAAAA/GAGAAA 6 -- int10--------
    rs106844651,2
    C--101493181(+) AACTTTT/-GAAAT 6 -- int11Minor allele frequency- -:0.50NA 2
    rs748485871,2
    --101500287(+) TAAACT/AGTGCT 6 -- int11Minor allele frequency- A:0.00CSA 1
    rs590679261,2
    C--131875225(+) CCCCC-/C/CA  
            
    AAAAA
    6 -- int11NA 2
    rs1125574051,2
    F--131875891(+) TCAAAG/ATACAA 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs713836301,2
    C--131878630(+) GCTAAT/-TTTTT 6 -- int11Minor allele frequency- -:0.00NA 2
    rs120004211,2
    C,F,H--131878913(+) cccgcC/Ttcggc 6 -- int17Minor allele frequency- T:0.00NS EA NA 424
    rs784114981,2
    C--131880344(+) TTTTTC/TCCCCC 6 -- int10--------
    rs107123191,2
    C--131881093(+) CCAGC-/TTTTTT 6 -- int1 trp30--------
    rs599789301,2
    C--131881093(+) TTTTTT/-GATGC 6 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for PPP2R4 (131873228 - 131911225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP2R4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509323CNV Insertion20534489
    nsv831729CNV Loss17160897
    nsv893909CNV Loss21882294
    nsv818725CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R4
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600756    OMIM disorders: --

    2 diseases for PPP2R4:    
    About MalaCards
    chromosome 5q deletion    hypersomnia

    2 diseases from the University of Copenhagen DISEASES database for PPP2R4:
    Alzheimer's disease     Cancer

    Find genes that share disorders with PPP2R4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PPP2R4 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paired helical filament 61.3 2 15616638 (1), 15475565 (1)
    neurofibrillary tangles 52.5 7 12937125 (2), 7946342 (1), 17662457 (1), 18208556 (1) (see all 5)
    tauopathies 51.1 1 18484086 (1)
    alzheimers disease 43.8 18 17662457 (2), 19278841 (2), 17086192 (1), 7812792 (1) (see all 16)
    acute undifferentiated leukemia 43.5 2 11231286 (1), 15703833 (1)
    tumors 38.3 96 18246411 (4), 11448528 (3), 15016329 (3), 19184590 (3) (see all 56)
    retinoblastoma 33 1 10542219 (1)
    blast crisis 26.2 4 16286244 (2), 16953242 (1)
    cancer 26.1 40 16477370 (3), 18213449 (2), 16299534 (2), 17313179 (2) (see all 28)
    neurodegenerative diseases 25.1 4 19940183 (1), 20110589 (1), 17303700 (1), 12937125 (1)

    Genetic Association Database (GAD): PPP2R4
    Human Genome Epidemiology (HuGE) Navigator: PPP2R4 (1 document)

    Export disorders for PPP2R4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PPP2R4 gene, integrated from 10 sources (see all 756):
    (articles sorted by number of sources associating them with PPP2R4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. (PubMed id 8530035)1, 2, 3, 9 Van Hoof C.... Goris J. (Genomics 1995)
    2. Structure and mechanism of the phosphotyrosyl phosphatase activator. (PubMed id 16916641)1, 2, 9 Chao Y.... Shi Y. (Mol. Cell 2006)
    3. The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. (PubMed id 16782712)1, 2, 9 Magnusdottir A.... Nordlund P. (J. Biol. Chem. 2006)
    4. Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene. (PubMed id 10880964)1, 2, 9 Janssens V....Goris J. (Eur. J. Biochem. 2000)
    5. Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A. (PubMed id 8195217)1, 2, 9 Cayla X.... Goris J. (J. Biol. Chem. 1994)
    6. Overexpression of the cis/trans isomerase PTPA triggers caspase 3- dependent apoptosis. (PubMed id 17333320)1, 2 Azam S.... Ramotar D. (Apoptosis 2007)
    7. Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. (PubMed id 16885030)1, 2 Leulliot N.... Goris J. (Mol. Cell 2006)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. (PubMed id 16380387)1, 9 Jordens J....Van Hoof C. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5524 HGNC: 9308 AceView: PPP2R4 Ensembl:ENSG00000119383 euGenes: HUgn5524
    ECgene: PPP2R4 H-InvDB: PPP2R4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PPP2R4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PPP2R4 gene:
    Search GeneIP for patents involving PPP2R4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2R4
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for PPP2R4 (PPP2R4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPP2R4   OriGene RNAi products in human, mouse, rat for PPP2R4  
     OriGene qPCR primer pairs and template standards for PPP2R4   OriGene Protein Over-expression Lysate for PPP2R4  
     OriGene MassSpec something-or-other for PPP2R4   OriGene clones in human, mouse for PPP2R4  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R4   OriGene Purified Protein for PPP2R4  
     OriGene ORF clones in mouse, rat for PPP2R4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP2R4   OriGene Custom Protein Services for PPP2R4  

     
     
     Block miRNA regulation of human, mouse, rat PPP2R4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPP2R4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R4 Predesigned siRNA for gene silencing in human, mouse, rat PPP2R4
     QuantiFast Probe-based Assays in human, mouse, rat PPP2R4 QuantiTect SYBR Green Assays in human, mouse, rat PPP2R4
     PCR Arrays including human, mouse, rat PPP2R4 Search Chromatin IP Primers for PPP2R4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R4  GeneGlobe Interaction Network for PPP2R4
     Regulatory tfbs in PPP2R4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPP2R4 GenScript cDNA clones with any tag delivered in your preferred vector for PPP2R4
     GenScript Custom Assay Services for PPP2R4 GenScript Custom overexpressing Cell Line Services for PPP2R4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PPP2R4 (PTPA)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPP2R4 antibodies
     PPP2R4 proteins
     PPP2R4 lysates
     Antibodies for PPP2R4
     See all of Abcam's Antibodies, Kits and Proteins for PPP2R4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PPP2R4
     Antibodies for PPP2R4
     ELISAs for PPP2R4
     CLIAs for PPP2R4



     Browse ESI BIO Cell Lines and PureStem Progenitors for PPP2R4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R4
     SwitchGear 3'UTR luciferase reporter plasmids for PPP2R4
     SwitchGear Promoter luciferase reporter plasmids for PPP2R4
     ThermoFisher Antibody for PPP2R4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP2R4
     LSBio Antibodies in human, mouse, rat for PPP2R4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PPP2R4
      Search eBioscience for proteins for PPP2R4
      Search eBioscience for elisas for PPP2R4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP2R4 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4