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Aliases for PPP2R3C Gene

Aliases for PPP2R3C Gene

  • Protein Phosphatase 2 Regulatory Subunit B'', Gamma 2
  • Protein Phosphatase 2 Regulatory Subunit B, Gamma 2 3 5
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma 2 3
  • Protein Phosphatase Subunit G5PR 3 4
  • C14orf10 3 4
  • G5pr 3 4
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Gamma 2
  • Rhabdomyosarcoma Antigen MU-RMS-40.6A/6C 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.6A 3
  • Rhabdomyosarcoma Antigen Mu-RMS-40.6C 3
  • Chromosome 14 Open Reading Frame 10 2
  • G4-1 3

External Ids for PPP2R3C Gene

Previous HGNC Symbols for PPP2R3C Gene

  • C14orf10

Previous GeneCards Identifiers for PPP2R3C Gene

  • GC14M034625
  • GC14M035554
  • GC14M015667

Summaries for PPP2R3C Gene

Entrez Gene Summary for PPP2R3C Gene

  • This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for PPP2R3C Gene

PPP2R3C (Protein Phosphatase 2 Regulatory Subunit B'', Gamma) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and AMPK signaling pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3B.

UniProtKB/Swiss-Prot for PPP2R3C Gene

  • May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

Tocris Summary for PPP2R3C Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R3C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R3C Gene

Genomics for PPP2R3C Gene

Regulatory Elements for PPP2R3C Gene

Enhancers for PPP2R3C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP2R3C on UCSC Golden Path with GeneCards custom track

Promoters for PPP2R3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2R3C on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2R3C Gene

Chromosome:
14
Start:
35,085,467 bp from pter
End:
35,122,517 bp from pter
Size:
37,051 bases
Orientation:
Minus strand

Genomic View for PPP2R3C Gene

Genes around PPP2R3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R3C Gene

Proteins for PPP2R3C Gene

  • Protein details for PPP2R3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q6-P2R3C_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B subunit gamma
    Protein Accession:
    Q969Q6
    Secondary Accessions:
    • B4DEN7
    • D3DS97
    • D3DS98
    • Q5GJ55
    • Q5GJ56
    • Q6P4G2
    • Q86TZ3
    • Q9NWR9

    Protein attributes for PPP2R3C Gene

    Size:
    453 amino acids
    Molecular mass:
    53316 Da
    Quaternary structure:
    • Interacts with MCM3AP/GANP. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
    SequenceCaution:
    • Sequence=AAT44532.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT44533.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP2R3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R3C Gene

Proteomics data for PPP2R3C Gene at MOPED

Post-translational modifications for PPP2R3C Gene

  • Ubiquitination at Lys 341
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R3C

No data available for DME Specific Peptides for PPP2R3C Gene

Domains & Families for PPP2R3C Gene

Gene Families for PPP2R3C Gene

Protein Domains for PPP2R3C Gene

Suggested Antigen Peptide Sequences for PPP2R3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969Q6

UniProtKB/Swiss-Prot:

P2R3C_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with PPP2R3C: view

Function for PPP2R3C Gene

Molecular function for PPP2R3C Gene

UniProtKB/Swiss-Prot Function:
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

Phenotypes for PPP2R3C Gene

genes like me logo Genes that share phenotypes with PPP2R3C: view

Animal Model Products

CRISPR Products

miRNA for PPP2R3C Gene

miRTarBase miRNAs that target PPP2R3C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R3C Gene

Localization for PPP2R3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R3C Gene

Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. {ECO:0000269 PubMed:15820313}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R3C Gene COMPARTMENTS Subcellular localization image for PPP2R3C gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005819 spindle IBA --
genes like me logo Genes that share ontologies with PPP2R3C: view

Pathways & Interactions for PPP2R3C Gene

genes like me logo Genes that share pathways with PPP2R3C: view

Gene Ontology (GO) - Biological Process for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0002759 regulation of antimicrobial humoral response IEA --
GO:0030865 cortical cytoskeleton organization IBA --
GO:0032147 activation of protein kinase activity IEA --
GO:0043029 T cell homeostasis IEA,IBA --
genes like me logo Genes that share ontologies with PPP2R3C: view

No data available for SIGNOR curated interactions for PPP2R3C Gene

Drugs & Compounds for PPP2R3C Gene

(3) Drugs for PPP2R3C Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPP2R3C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ceramide
3102-57-6
DL-AP3
20263-06-3

(5) Tocris Compounds for PPP2R3C Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
genes like me logo Genes that share compounds with PPP2R3C: view

Transcripts for PPP2R3C Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - - -
SP7:
SP8:
SP9: - - - -
SP10:

Relevant External Links for PPP2R3C Gene

GeneLoc Exon Structure for
PPP2R3C
ECgene alternative splicing isoforms for
PPP2R3C

Expression for PPP2R3C Gene

mRNA expression in normal human tissues for PPP2R3C Gene

Protein differential expression in normal tissues from HIPED for PPP2R3C Gene

This gene is overexpressed in Testis (30.3), Fetal heart (25.3), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R3C Gene



SOURCE GeneReport for Unigene cluster for PPP2R3C Gene Hs.530712

mRNA Expression by UniProt/SwissProt for PPP2R3C Gene

Q969Q6-P2R3C_HUMAN
Tissue specificity: Ubiquitously expressed in brain and other tissues.
genes like me logo Genes that share expression patterns with PPP2R3C: view

Protein tissue co-expression partners for PPP2R3C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP2R3C Gene

Orthologs for PPP2R3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R3C 36
  • 100 (a)
OneToOne
PPP2R3C 35
  • 99.63 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R3C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r3c 36
  • 98 (a)
OneToOne
Ppp2r3c 16
Ppp2r3c 35
  • 90.29 (n)
  • 98.23 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R3C 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R3C 36
  • 98 (a)
OneToOne
PPP2R3C 35
  • 93.75 (n)
  • 98.01 (a)
cow
(Bos Taurus)
Mammalia PPP2R3C 36
  • 98 (a)
OneToOne
PPP2R3C 35
  • 93.52 (n)
  • 98.45 (a)
rat
(Rattus norvegicus)
Mammalia Ppp2r3c 35
  • 90.43 (n)
  • 97.79 (a)
chicken
(Gallus gallus)
Aves PPP2R3C 36
  • 89 (a)
OneToOne
PPP2R3C 35
  • 82.15 (n)
  • 92 (a)
lizard
(Anolis carolinensis)
Reptilia PPP2R3C 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68494 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17328 35
ppp2r3c 35
  • 76.19 (n)
  • 86.61 (a)
zebrafish
(Danio rerio)
Actinopterygii ppp2r3c 36
  • 84 (a)
OneToOne
zgc55473 35
ppp2r3c 35
  • 73.44 (n)
  • 86.61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FASS 35
  • 50.23 (n)
  • 39.4 (a)
rice
(Oryza sativa)
Liliopsida Os05g0149800 35
  • 52 (n)
  • 40.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1229 35
Species with no ortholog for PPP2R3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP2R3C Gene

ENSEMBL:
Gene Tree for PPP2R3C (if available)
TreeFam:
Gene Tree for PPP2R3C (if available)

Paralogs for PPP2R3C Gene

Paralogs for PPP2R3C Gene

genes like me logo Genes that share paralogs with PPP2R3C: view

Variants for PPP2R3C Gene

Sequence variations from dbSNP and Humsavar for PPP2R3C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8017547 -- 35,115,256(+) ctcct(A/G)agctc intron-variant, upstream-variant-2KB
rs8018116 -- 35,115,066(+) tgagc(G/T)taaga intron-variant, upstream-variant-2KB
rs8019351 -- 35,119,090(+) tggag(A/C)gcagt intron-variant
rs8019482 -- 35,119,076(+) tctat(C/T)gccca intron-variant
rs8019523 -- 35,119,140(+) tcaag(C/T)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R3C Gene

Variant ID Type Subtype PubMed ID
nsv901602 CNV Loss 21882294
dgv1871n71 CNV Loss 21882294
nsv901612 CNV Gain+Loss 21882294
nsv901614 CNV Loss 21882294
nsv901615 CNV Loss 21882294

Variation tolerance for PPP2R3C Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R3C Gene

HapMap Linkage Disequilibrium report
PPP2R3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R3C Gene

Disorders for PPP2R3C Gene

Relevant External Links for PPP2R3C

Genetic Association Database (GAD)
PPP2R3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R3C

No disorders were found for PPP2R3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R3C Gene

Publications for PPP2R3C Gene

  1. MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR. (PMID: 12167160) Kono Y. … Sakaguchi N. (Genes Cells 2002) 2 3 4 67
  2. Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. (PMID: 16129705) Xing Y. … Sakaguchi N. (J. Exp. Med. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for PPP2R3C Gene

Sources for PPP2R3C Gene

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