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PPP2R3C Gene

protein-coding   GIFtS: 52
GCID: GC14M035554

Protein Phosphatase 2, Regulatory Subunit B'', Gamma

(Previous names: chromosome 14 open reading frame 10, protein phosphatase...)
(Previous symbol: C14orf10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit B'', Gamma1 2     G4-12
C14orf101 2 3     G5pr2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B'', Gamma1 2     Rhabdomyosarcoma Antigen MU-RMS-40.6A2
Protein Phosphatase Subunit G5PR2 3     Rhabdomyosarcoma Antigen Mu-RMS-40.6C2
Rhabdomyosarcoma Antigen MU-RMS-40.6A/6C2 3     Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit
Gamma2
Chromosome 14 Open Reading Frame 101     G5PR3

External Ids:    HGNC: 174851   Entrez Gene: 550122   Ensembl: ENSG000000920207   UniProtKB: Q969Q63   

Export aliases for PPP2R3C gene to outside databases

Previous GC identifers: GC14M034625 GC14M015667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPP2R3C Gene:
PPP2R3C (protein phosphatase 2, regulatory subunit B'', gamma) is a protein-coding gene. Diseases associated with PPP2R3C include rhabdomyosarcoma, and holoprosencephaly. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3A.

UniProtKB/Swiss-Prot: P2R3C_HUMAN, Q969Q6
Function: May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the
activation-induced cell death of B-cells (By similarity)

summary for PPP2R3C Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R3C gene promoter:
         TBP   C/EBPbeta   AML1a   Olf-1   CUTL1   LCR-F1   PPAR-gamma1   SRY   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2R3C promoter sequence
   Search Chromatin IP Primers for PPP2R3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.2

PPP2R3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R3C gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M035554:  view genomic region     (about GC identifiers)

Start:
35,554,673 bp from pter      End:
35,591,723 bp from pter
Size:
37,051 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P2R3C_HUMAN, Q969Q6 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma  
Size: 453 amino acids; 53316 Da
Subunit: Interacts with MCM3AP/GANP (By similarity). Interacts with PPP5C, and the phosphatase 2A core enzyme
composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A
Developmental stage: Expressed in fetal brain
Sequence caution: Sequence=AAT44532.1; Type=Erroneous initiation; Sequence=AAT44533.1; Type=Erroneous initiation;
Secondary accessions: B4DEN7 D3DS97 D3DS98 Q5GJ55 Q5GJ56 Q6P4G2 Q86TZ3 Q9NWR9
Alternative splicing: 2 isoforms:  Q969Q6-1   Q969Q6-2   

Explore the universe of human proteins at neXtProt for PPP2R3C: NX_Q969Q6

Explore proteomics data for PPP2R3C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys341
  • Modification sites at PhosphoSitePlus

  • See PPP2R3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060387.2  
    ENSEMBL proteins: 
     ENSP00000451075   ENSP00000261475   ENSP00000451416   ENSP00000452173   ENSP00000450649  
     ENSP00000452436   ENSP00000452263   ENSP00000451174   ENSP00000451994   ENSP00000450716  
     ENSP00000452266   ENSP00000452194   ENSP00000450429   ENSP00000451450   ENSP00000452534  
     ENSP00000451523   ENSP00000450815   ENSP00000451423  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q969Q6

    ProtoNet protein and cluster: Q969Q6

    UniProtKB/Swiss-Prot: P2R3C_HUMAN, Q969Q6
    Similarity: Contains 2 EF-hand domains


    PPP2R3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2R3C_HUMAN, Q969Q6
    Function: May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the
    activation-induced cell death of B-cells (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    PPP2R3C for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp2r3c):
     hematopoietic system  immune system 

    PPP2R3C for phenotypes           About GeneDecksing

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target PPP2R3C:
    hsa-mir-375 (MIRT019852)

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    hsa-miR-4310 hsa-miR-1179 hsa-miR-107 hsa-miR-103a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2R3C_HUMAN, Q969Q6: Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Localization is cell cycle-dependent.
    Localizes to the cytoplasm during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--

    PPP2R3C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R3C About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Dopaminergic synapse0.37
    2PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    3mRNA surveillance pathway
    mRNA surveillance pathway
    4Adrenergic signaling in cardiomyocytes
    Adrenergic signaling in cardiomyocytes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Kegg Pathways  (Kegg details for PPP2R3C):
        mRNA surveillance pathway
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Dopaminergic synapse


    PPP2R3C for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R3C
    Interactions:

        GeneGlobe Interaction Network for PPP2R3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PPP2R3C (Q969Q63 ENSP000002614754) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC33Q8N5R63I2D: score=1 
    PPP2R1AENSP000003248044STRING: ENSP00000324804
    PPP2R1BENSP000003113444STRING: ENSP00000311344
    UBCENSP000003448184STRING: ENSP00000344818
    PPP2CAENSP000004184474STRING: ENSP00000418447
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis IEA--
    GO:0002759regulation of antimicrobial humoral response IEA--
    GO:0032147activation of protein kinase activity IEA--
    GO:0043029T cell homeostasis IEA--
    GO:0045579positive regulation of B cell differentiation IEA--

    PPP2R3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for PPP2R3C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R3C gene: 
    NM_017917.2  

    Unigene Clusters for PPP2R3C:

    Protein phosphatase 2, regulatory subunit B'', gamma
    Hs.530712  [show with all ESTs], Hs.621667
    Unigene Representative Sequences: AY157304, BC037797
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000553273 ENST00000261475(uc001wss.3 uc001wst.3) ENST00000554222(uc010tpr.2 uc001wsu.3)
    ENST00000555219 ENST00000557074 ENST00000557217 ENST00000554899 ENST00000555614
    ENST00000555726 ENST00000554361 ENST00000554265 ENST00000557773(uc010amn.1)
    ENST00000555630 ENST00000554488 ENST00000557288 ENST00000554563 ENST00000555644(uc001wsw.3)
    ENST00000557278(uc001wsx.1)
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    hsa-miR-4310 hsa-miR-1179 hsa-miR-107 hsa-miR-103a
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    Additional mRNA sequence: BC037797.1 

    Selected DOTS entries (see all 29):

    DT.100827152  DT.443519  DT.102835721  DT.100827154  DT.95310129  DT.100789559  DT.95310132  DT.120788728 
    DT.441387  DT.120788738  DT.91764740  DT.100827156  DT.91895302  DT.99998762  DT.100027376  DT.99946631 
    DT.100827151  DT.100827155  DT.102833015  DT.120788713  DT.40249305  DT.95310127  DT.95353261  DT.100027373 

    Selected AceView cDNA sequences (see all 238):

    BM718140 BM918395 BX360873 CF128087 AA235198 BU681925 AA129968 AY157304 
    AI015553 BX248043 BQ941925 BU679551 BQ417420 AA633831 BE266653 BM141910 
    CR594274 AI810956 CR590316 AA234901 BM823252 BP353558 CR618013 NM_017917 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3C (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                      -     -     -           -                             -     -                 -                 -                     
    SP2:                                      -     -     -           -                             -     -                                   -                     
    SP3:                                                              -                             -     -                                   -                     
    SP4:                                                              -                                                                                             
    SP5:                                      -                       -                                                                                             


    ECgene alternative splicing isoforms for PPP2R3C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTTCATT
    PPP2R3C Expression
    About this image

    PPP2R3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R3C Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.530712 Hs.621667

    UniProtKB/Swiss-Prot: P2R3C_HUMAN, Q969Q6
    Tissue specificity: Ubiquitously expressed in brain and other tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R3C gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r3c1 , 5 protein phosphatase 2, regulatory subunit B'', gamma1, 5 90.29(n)1
    98.23(a)1
      12 (23.90 cM)5
    590321  NM_021529.31  NP_067504.21 
     552808145 
    chicken
    (Gallus gallus)
    Aves PPP2R3C1 protein phosphatase 2, regulatory subunit B', gamma 82.15(n)
    92(a)
      423324  XM_421240.4  XP_421240.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R3C6
    protein phosphatase 2, regulatory subunit B'', gam...
    89(a)
    1 ↔ 1
    2(54527365-54548661)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684942 hypothetical protein MGC68494 79.27(n)    BC059959.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554732 similar to phosphatase subunit gene g4-1 76.22(n)   393100  BC044178.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FASS1 FASS 50.23(n)
    39.4(a)
      831976  NM_121863.3  NP_568364.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01498001 Os05g0149800 52(n)
    40.32(a)
      4337821  NM_001061195.1  NP_001054660.1 


    ENSEMBL Gene Tree for PPP2R3C (if available)
    TreeFam Gene Tree for PPP2R3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R3C gene
    PPP2R3A2  PPP2R3B2  
    1 SIMAP similar gene for PPP2R3C using alignment to 11 protein entries:     P2R3C_HUMAN (see all proteins):
    C14ORF10

    PPP2R3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R3C (see all 742)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496757591,2
    --35554191(+) GAGTTA/TGAGAC 1 -- int10--------
    rs1444509131,2
    --35554208(+) GGCCAA/GCATGG 1 -- int10--------
    rs795984311,2
    C--35554330(+) AAAAAA/GTCCTA 1 -- int12Minor allele frequency- G:0.06NA WA 120
    rs1853981641,2
    C--35554361(+) TGGCTC/TTACTC 1 -- int10--------
    rs1893244711,2
    --35554363(+) GCTCTA/TCTCAT 1 -- int10--------
    rs111568731,2
    C,F,H--35554375(+) AATGGG/TAAAGT 1 -- int18Minor allele frequency- T:0.08NS EA WA NA CSA 543
    rs116255071,2
    C,F,H--35554376(+) ATGGGA/CAAGTT 1 -- int117Minor allele frequency- C:0.16NS EA NA WA 1146
    rs1379114761,2
    C--35554410(+) TATAG-/ACACACA 1 -- int10--------
    rs125888101,2
    C,F,H--35554484(+) ACTGTC/TAGAAA 1 -- int114Minor allele frequency- T:0.21NA NS EA WA 912
    rs1808707721,2
    --35554540(+) GAACAC/TCATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for PPP2R3C (35554673 - 35591723 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PPP2R3C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901615CNV Loss21882294
    dgv1871n71CNV Loss21882294
    nsv901602CNV Loss21882294
    nsv901614CNV Loss21882294
    nsv901612CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for PPP2R3C:    
    About MalaCards
    rhabdomyosarcoma    holoprosencephaly    peritonitis


    PPP2R3C for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP2R3C

    Export disorders for PPP2R3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R3C gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with PPP2R3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR. (PubMed id 12167160)1, 2, 3 Kono Y.... Sakaguchi N. (Genes Cells 2002)
    2. Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. (PubMed id 16129705)1, 3 Xing Y....Sakaguchi N. (J. Exp. Med. 2005)
    3. Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes. (PubMed id 15820313)1, 2 Kamnasaran D.... Cox D.W. (Genomics 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Transgenic overexpression of G5PR that is normally augmented in centrocytes impairs the enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice. (PubMed id 22753944)1 Kitabatake M....Sakaguchi N. (J. Immunol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Phosphorylation-dependent association of the G4-1/G5PR regulatory subunit with IKKI^ negatively modulates NF-I_B activation through recruitment of protein phosphatase 5. (PubMed id 20925653)1 Chiang C.W....Chou C.K. (Biochem. J. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55012 HGNC: 17485 AceView: C14orf10 Ensembl:ENSG00000092020 euGenes: HUgn55012
    ECgene: PPP2R3C Kegg: 55012 H-InvDB: PPP2R3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R3C gene:
    Search GeneIP for patents involving PPP2R3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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