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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP2R3B Gene

protein-coding   GIFtS: 58
GCID: GC0XM000264

Protein Phosphatase 2, Regulatory Subunit B'', Beta

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
(Previous symbol: PPP2R3L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 2, Regulatory Subunit B'', Beta1 2     NY-REN-8 Antigen2
PPP2R3L1 2 3     PP2A, Subunit B, PR48 Isoform2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B'', Beta1 2     Serine/Threonine Protein Phosphatase 2A, 48kDa Regulatory Subunit B2
NYREN82     Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit
Beta2
PPP2R3LY2     PP2A Subunit B Isoform PR483
PR482     Protein Phosphatase 2A 48 KDa Regulatory Subunit3

External Ids:    HGNC: 134171   Entrez Gene: 282272   Ensembl: ENSG000001673937   OMIM: 3003395   UniProtKB: Q9Y5P83   

Export aliases for PPP2R3B gene to outside databases

Previous GC identifers: GC00U991190 GC0YU900001


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R3B Gene:
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in
the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins
composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is
encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These
different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the
holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into
subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. (provided by
RefSeq, Apr 2010)

GeneCards Summary for PPP2R3B Gene: 
PPP2R3B (protein phosphatase 2, regulatory subunit B'', beta) is a protein-coding gene. Diseases associated with PPP2R3B include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are Cell Cycle, Mitotic and Mitotic G1-G1/S phases. GO annotations related to this gene include protein phosphatase type 2A regulator activity and calcium ion binding. An important paralog of this gene is PPP2R3A.

UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment

summary for PPP2R3B Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167193.1  NC_000024.9  NT_167201.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP2R3B gene promoter:
         PPAR-alpha   RP58   CUTL1   STAT5A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP2R3B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP2R3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33; Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp11.3

PPP2R3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R3B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM000264:  view genomic region     (about GC identifiers)

Start:
294,668 bp from pter      End:
347,690 bp from pter
Size:
53,023 bases      Orientation:
minus strand

1 alternative location:
ChrY- 244,668-297,690     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta  
Size: 575 amino acids; 65061 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6
Subcellular location: Nucleus
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Sequence caution: Sequence=AAD38515.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for PPP2R3B:
4I5L (3D)        4I5N (3D)    
Secondary accessions: Q6P4G9 Q7RTT1 Q96H01
Alternative splicing: 2 isoforms:  Q9Y5P8-1   Q9Y5P8-2   

Explore the universe of human proteins at neXtProt for PPP2R3B: NX_Q9Y5P8

Explore proteomics data for PPP2R3B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5P8

  • PPP2R3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP2R3B Protein Expression
    REFSEQ proteins: NP_037371.2  
    ENSEMBL proteins: 
     ENSP00000375080   ENSP00000371038  
    Reactome Protein details: Q9Y5P8
    Human Recombinant Protein Products for PPP2R3B: 
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    Novus Biologicals PPP2R3B Proteins
    Novus Biologicals PPP2R3B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex ISS--
    GO:0005634nucleus TAS10629059
    GO:0005654nucleoplasm TAS--

    PPP2R3B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits
    PAR1: Pseudoautosomal regions / PAR1
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9Y5P8

    ProtoNet protein and cluster: Q9Y5P8

    UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8
    Similarity: Contains 1 EF-hand domain


    PPP2R3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2R3B_HUMAN, Q9Y5P8
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS--
    GO:0004722protein serine/threonine phosphatase activity ISS--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI9847399
    GO:0008601protein phosphatase type 2A regulator activity TAS10629059
         
    PPP2R3B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP2R3B:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP2R3B 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP2R3B About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1/S Transition0.80
    3E2F mediated regulation of DNA replication
    E2F mediated regulation of DNA replication0.45
    Inhibition of replication initiation of damaged DNA by RB1/E2F10.36
    4Cyclins and Cell Cycle Regulation
    G1 Phase0.32
    Cyclin D associated events in G10.32
    5Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.98

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PPP2R3B
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Signal transduction PKA signaling


    4 GeneGo (Thomson Reuters) Pathways for PPP2R3B
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    4 BioSystems Pathways for PPP2R3B
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway
    Regulation of retinoblastoma protein

    5/8        Reactome Pathways for PPP2R3B (see all 8)
        G1 Phase
    Mitotic G1-G1/S phases
    Inhibition of replication initiation of damaged DNA by RB1/E2F1
    Cell Cycle
    E2F mediated regulation of DNA replication


    3         Kegg Pathways  (Kegg details for PPP2R3B):
        mRNA surveillance pathway
    PI3K-Akt signaling pathway
    Dopaminergic synapse


    PPP2R3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP2R3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for PPP2R3B (Q9Y5P83 ENSP000003750804) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301533, ENSP000003248044I2D: score=4 STRING: ENSP00000324804
    CDC6Q997413, ENSP000002097284I2D: score=3 STRING: ENSP00000209728
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PPP2R1BP301543, ENSP000003113444I2D: score=1 STRING: ENSP00000311344
    PPP2CAP677753, ENSP000004184474I2D: score=2 STRING: ENSP00000418447
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006470protein dephosphorylation ISS--
    GO:0007050cell cycle arrest TAS10629059

    PPP2R3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PPP2R3B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PPP2R3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    3 HMDB Compounds for PPP2R3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PPP2R3B / P2R3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP2R3B gene (2 alternative transcripts): 
    NM_013239.4  NM_199326.1  

    Unigene Cluster for PPP2R3B:

    Protein phosphatase 2, regulatory subunit B'', beta
    Hs.124942  [show with all ESTs]
    Unigene Representative Sequence: AB209137
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390665(uc004cpf.3 uc004cpg.3) ENST00000479438 ENST00000477110
    ENST00000468169 ENST00000484364 ENST00000477636 ENST00000445792(uc011mha.2)
    ENST00000496630 ENST00000475859 ENST00000381625
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB209137.1 AF135016.1 AF155098.1 AK293506.1 BC011180.1 BC063429.1 

    18 DOTS entries:

    DT.101977903  DT.109191  DT.100814348  DT.100814351  DT.75167033  DT.99973164  DT.75181625  DT.91987873 
    DT.100708521  DT.95268121  DT.100814349  DT.100814350  DT.120650983  DT.120650987  DT.121305106  DT.121305116 
    DT.70101738  DT.75189514 

    24/94 AceView cDNA sequences (see all 94):

    BQ070728 BU621602 AI797466 NM_013239 BQ889485 BM714230 BF058956 BM715684 
    NM_199326 BM711041 BQ574899 BK000521 BX282407 BM475926 BX355787 AI926984 
    BC063429 AL583511 BC009032 AF135016 BE349492 BM928753 AI440374 BQ448572 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3B (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                  -                       -                                             
    SP2:                                                                                                                        
    SP3:        -                                                                                                               
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for PPP2R3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP2R3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGGACGAG
    PPP2R3B Expression
    About this image


    See PPP2R3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP2R3B

    SOURCE GeneReport for Unigene cluster: Hs.124942
        SABiosciences Custom PCR Arrays for PPP2R3B
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R3B gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PPP2R3B1 protein phosphatase 2, regulatory subunit B'', beta 67.89(n)
    75.87(a)
      418670  XM_416866.3  XP_416866.2 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R3B6
    Uncharacterized protein
    65(a)
    1 ↔ 1
    3(112265205-112310535)
    zebrafish
    (Danio rerio)
    Actinopterygii ppp2r3b1 protein phosphatase 2, regulatory subunit B'', beta 65.19(n)
    66.67(a)
      566032  XM_689298.5  XP_694390.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47331 CG4733 63.35(n)
    57.96(a)
      42368  NM_142585.3  NP_650842.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C06G1.51 Protein C06G1.5 47.94(n)
    40.35(a)
      181721  NM_078289.3  NP_510690.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G544501 calcium-binding EF-hand-containing protein 46.75(n)
    41.06(a)
      841887  NM_104323.3  NP_175847.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04766001 hypothetical protein 47.58(n)
    39.31(a)
      4348893  NM_001071385.1  NP_001064850.1 
            Species with no ortholog for PPP2R3B

    ENSEMBL Gene Tree for PPP2R3B (if available)
    TreeFam Gene Tree for PPP2R3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP2R3B gene
    PPP2R3A2  PPP2R3C2  
    2 SIMAP similar genes for PPP2R3B using alignment to 3 protein entries:     P2R3B_HUMAN (see all proteins):
    DKFZp434G155    PPP2R3A

    PPP2R3B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PPP2R3B
    PGOHUM00000248820 PGOHUM00000248834


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in PPP2R3B are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0553564
    ----see VAR_0553562 A V mis40--------
    VAR_0351094
    ----see VAR_0351092 D E mis40--------

    HapMap Linkage Disequilibrium report for PPP2R3B (294668 - 347690 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PPP2R3B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv27923CNV Loss19812545
    esv25834CNV Gain+Loss19812545
    dgv2431e1CNV Complex17122850


    Locus Specific Mutation Databases (LSDB): PPP2R3B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300339    OMIM disorders: --

    7 diseases for PPP2R3B:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    patau syndrome
    cerebritis    renal cell carcinoma    retinoblastoma


    PPP2R3B for disorders           About GeneDecksing


    Export disorders for PPP2R3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP2R3B gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PPP2R3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with cdc6 and modulates DNA replication in human cells. (PubMed id 10629059)1, 2, 9 Yan Z.... Williams R.S. (2000)
    2. Identification and characterization of B''-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. (PubMed id 12605688)1, 2 Stevens I....Van Hoof C. (2003)
    3. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. (PubMed id 11173861)1, 3 Schiebel K....Rappold G. (2000)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1 Goudreault M....Gingras A.C. (2009)
    6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28227 HGNC: 13417 AceView: PR48 Ensembl:ENSG00000167393 euGenes: HUgn28227
    ECgene: PPP2R3B Kegg: 28227 H-InvDB: PPP2R3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP2R3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP2R3B gene:
    Search GeneIP for patents involving PPP2R3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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