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PPP2R3B Gene

protein-coding   GIFtS: 59
GCID: GC0XM000264

Protein Phosphatase 2, Regulatory Subunit B'', Beta

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
(Previous symbol: PPP2R3L)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit B'', Beta1 2     NY-REN-8 Antigen2
PPP2R3L1 2 3     PP2A, Subunit B, PR48 Isoform2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B'', Beta1 2     Serine/Threonine Protein Phosphatase 2A, 48kDa Regulatory Subunit B2
PR482 5     Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit
Beta2
NYREN82     PP2A Subunit B Isoform PR483
PPP2R3LY2     Protein Phosphatase 2A 48 KDa Regulatory Subunit3

External Ids:    HGNC: 134171   Entrez Gene: 282272   Ensembl: ENSG000001673937   OMIM: 3003395   UniProtKB: Q9Y5P83   

Export aliases for PPP2R3B gene to outside databases

Previous GC identifers: GC00U991190 GC0YU900001


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R3B Gene:
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in
the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins
composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is
encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These
different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the
holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into
subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. (provided by
RefSeq, Apr 2010)

GeneCards Summary for PPP2R3B Gene:
PPP2R3B (protein phosphatase 2, regulatory subunit B'', beta) is a protein-coding gene. Diseases associated with PPP2R3B include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include phosphoprotein phosphatase activity and calcium ion binding. An important paralog of this gene is PPP2R3A.

UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment

summary for PPP2R3B Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_187358.1  NC_000024.10  NT_167201.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R3B gene promoter:
         PPAR-alpha   RP58   CUTL1   STAT5A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP2R3B promoter sequence
   Search Chromatin IP Primers for PPP2R3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33; Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp11.3

PPP2R3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R3B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM000264:  view genomic region     (about GC identifiers)

Start:
294,668 bp from pter      End:
347,690 bp from pter
Size:
53,023 bases      Orientation:
minus strand

1 alternative location:
ChrY- 244,668-297,690     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta  
Size: 575 amino acids; 65061 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Sequence caution: Sequence=AAD38515.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for PPP2R3B:
4I5L (3D)        4I5N (3D)    
Secondary accessions: Q6P4G9 Q7RTT1 Q96H01
Alternative splicing: 2 isoforms:  Q9Y5P8-1   Q9Y5P8-2   

Explore the universe of human proteins at neXtProt for PPP2R3B: NX_Q9Y5P8

Explore proteomics data for PPP2R3B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys170, Lys179
  • Modification sites at PhosphoSitePlus

  • See PPP2R3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037371.2  
    ENSEMBL proteins: 
     ENSP00000375080   ENSP00000371038  
    Reactome Protein details: Q9Y5P8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits
    PAR1: Pseudoautosomal regions / PAR1
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9Y5P8

    ProtoNet protein and cluster: Q9Y5P8

    UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8
    Similarity: Contains 1 EF-hand domain


    PPP2R3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2R3B_HUMAN, Q9Y5P8
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS--
    GO:0004722protein serine/threonine phosphatase activity ISS--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI9847399
    GO:0008601protein phosphatase type 2A regulator activity TAS10629059
         
    PPP2R3B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP2R3B:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2R3B_HUMAN, Q9Y5P8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex ISS--
    GO:0005634nucleus TAS10629059
    GO:0005654nucleoplasm TAS--

    PPP2R3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R3B About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1E2F mediated regulation of DNA replication
    G1/S Transition0.81
    E2F mediated regulation of DNA replication0.30
    Mitotic G1-G1/S phases0.81
    Inhibition of replication initiation of damaged DNA by RB1/E2F10.00
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Cyclins and Cell Cycle Regulation
    G1 Phase0.31
    Cyclin D associated events in G10.31
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    5Cell cycle Regulation of G1 S transition part 1
    Cell cycle Regulation of G1 S transition part 1 0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R3B (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    4 GeneGo (Thomson Reuters) Pathways for PPP2R3B
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    4 BioSystems Pathways for PPP2R3B
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway
    Regulation of retinoblastoma protein


    2 Reactome Pathways for PPP2R3B
        Inhibition of replication initiation of damaged DNA by RB1/E2F1
    Cyclin D associated events in G1


    4 Kegg Pathways  (Kegg details for PPP2R3B):
        mRNA surveillance pathway
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Dopaminergic synapse


    PPP2R3B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R3B
    Interactions:

        Search GeneGlobe Interaction Network for PPP2R3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R3B (Q9Y5P83 ENSP000003750804) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301533, ENSP000003248044I2D: score=4 STRING: ENSP00000324804
    CDC6Q997413, ENSP000002097284I2D: score=3 STRING: ENSP00000209728
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PPP2R1BP301543, ENSP000003113444I2D: score=1 STRING: ENSP00000311344
    PPP2CAP677753, ENSP000004184474I2D: score=2 STRING: ENSP00000418447
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006470protein dephosphorylation ISS--
    GO:0007050cell cycle arrest TAS10629059
    GO:0050790regulation of catalytic activity TAS10629059

    PPP2R3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP2R3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    3 HMDB Compounds for PPP2R3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R3B gene (2 alternative transcripts): 
    NM_013239.4  NM_199326.1  

    Unigene Cluster for PPP2R3B:

    Protein phosphatase 2, regulatory subunit B'', beta
    Hs.124942  [show with all ESTs]
    Unigene Representative Sequence: AB209137
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390665(uc004cpf.3 uc004cpg.3) ENST00000479438 ENST00000477110
    ENST00000468169 ENST00000484364 ENST00000477636 ENST00000445792(uc011mha.2)
    ENST00000496630 ENST00000475859 ENST00000381625
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209137.1 AF135016.1 AF155098.1 AK293506.1 BC011180.1 BC063429.1 

    18 DOTS entries:

    DT.101977903  DT.109191  DT.100814348  DT.100814351  DT.75167033  DT.99973164  DT.75181625  DT.91987873 
    DT.100708521  DT.95268121  DT.100814349  DT.100814350  DT.120650983  DT.120650987  DT.121305106  DT.121305116 
    DT.70101738  DT.75189514 

    Selected AceView cDNA sequences (see all 94):

    BQ574899 BQ889485 BU621602 BM715684 NM_199326 BM711041 AI797466 BX282407 
    BF058956 BK000521 NM_013239 BQ070728 BM714230 AW772343 AL045691 AI989404 
    AL555389 AL157501 BQ051062 BM928753 BC009032 AL583511 BQ018931 AF135016 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3B (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                  -                       -                                             
    SP2:                                                                                                                        
    SP3:        -                                                                                                               
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for PPP2R3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGGACGAG
    PPP2R3B Expression
    About this image

    PPP2R3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124942
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R3B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PPP2R3B1 protein phosphatase 2, regulatory subunit B'', beta 68.29(n)
    77.26(a)
      418670  XM_416866.4  XP_416866.2 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R3B6
    protein phosphatase 2, regulatory subunit B'', bet...
    64(a)
    1 ↔ 1
    3(112265205-112310535)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppp2r3b1 protein phosphatase 2, regulatory subunit B'', beta 63.24(n)
    67.73(a)
      780131  NM_001079206.1  NP_001072674.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp2r3b1 protein phosphatase 2, regulatory subunit B'', beta 64.55(n)
    65.26(a)
      566032  XM_005167860.1  XP_005167917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47331 CG4733 64.34(n)
    59.69(a)
      42368  NM_001260268.1  NP_001247197.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C06G1.56
    Protein C06G1.5, isoform b
    27(a)
    1 ↔ 1
    X(16638278-16643560) WBGene00015548
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G440901 AT5G44090 46.45(n)
    38.51(a)
      834432  NM_123776.3  NP_199222.1 
            Species with no ortholog for PPP2R3B

    ENSEMBL Gene Tree for PPP2R3B (if available)
    TreeFam Gene Tree for PPP2R3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R3B gene
    PPP2R3A2  PPP2R3C2  
    2 SIMAP similar genes for PPP2R3B using alignment to 3 protein entries:     P2R3B_HUMAN (see all proteins):
    DKFZp434G155    PPP2R3A

    PPP2R3B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PPP2R3B
    PGOHUM00000248820 PGOHUM00000248834


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for PPP2R3B    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11335201,2,4
    ----see VAR_0553562 mis40--------
    rs38135941,2,4
    ----see VAR_0351092 mis40--------

    HapMap Linkage Disequilibrium report for PPP2R3B (294668 - 347690 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PPP2R3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv27923CNV Loss19812545
    esv25834CNV Gain+Loss19812545
    dgv2431e1CNV Complex17122850

    Locus Specific Mutation Databases (LSDB): PPP2R3B

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R3B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300339    OMIM disorders: --

    7 diseases for PPP2R3B:    
    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    patau syndrome
    cerebritis    renal cell carcinoma    retinoblastoma


    PPP2R3B for disorders           About GeneDecksing


    Export disorders for PPP2R3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R3B gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with PPP2R3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with cdc6 and modulates DNA replication in human cells. (PubMed id 10629059)1, 2, 9 Yan Z.... Williams R.S. (Mol. Cell. Biol. 2000)
    2. Identification and characterization of B''-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. (PubMed id 12605688)1, 2 Stevens I....Van Hoof C. (Eur. J. Biochem. 2003)
    3. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. (PubMed id 11173861)1, 3 Schiebel K....Rappold G. (Cytogenet. Cell Genet. 2000)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    7. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28227 HGNC: 13417 AceView: PR48 Ensembl:ENSG00000167393 euGenes: HUgn28227
    ECgene: PPP2R3B Kegg: 28227 H-InvDB: PPP2R3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R3B gene:
    Search GeneIP for patents involving PPP2R3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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