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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP2R3B Gene

protein-coding   GIFtS: 57
GCID: GC0XM000264

protein phosphatase 2, regulatory subunit B'', beta

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
(Previous symbol: PPP2R3L)
 Explore 8 diseases affiliated with
PPP2R3B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPP2R3B    

Aliases
for PPP2R3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase 2, Regulatory Subunit B'', Beta1 2     NY-REN-8 Antigen2
PPP2R3L1 2 3     PP2A, Subunit B, PR48 Isoform2
PPP2R3LY1 2     Serine/Threonine Protein Phosphatase 2A, 48kDa Regulatory Subunit B2
PR481 2     Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B'', Beta1 2     PP2A Subunit B Isoform PR483
NYREN82     Protein Phosphatase 2A 48 KDa Regulatory Subunit3

External Ids:    HGNC: 134171   Entrez Gene: 282272   Ensembl: ENSG000001673937   OMIM: 3003395   UniProtKB: Q9Y5P83   

Export aliases for PPP2R3B gene to outside databases

Previous GC identifers: GC00U991190 GC0YU900001


Summaries
for PPP2R3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPP2R3B:
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the
negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed
of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a
diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different
regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The
product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product
of this gene belongs to the beta subfamily of regulatory subunit B''. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct
the localization of the catalytic enzyme to a particular subcellular compartment

summary for PPP2R3B:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R3B


Genomic Views
for PPP2R3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_000024.9  NC_018934.1  NT_167193.1  NT_167201.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP2R3B gene promoter:
         PPAR-alpha   RP58   CUTL1   STAT5A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP2R3B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP2R3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33; Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp11.3

PPP2R3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R3B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM000264:  view genomic region     (about GC identifiers)

Start:
 294,668 bp from pter      End:
 347,690 bp from pter
Size:
 53,023 bases      Orientation:
 minus strand

1 alternative location:
ChrY- 244,668-297,690     

Proteins
for PPP2R3B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta  
Size: 575 amino acids; 65061 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a
65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits.
Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,
R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell
signaling molecules. Interacts with N-terminal region of CDC6
Subcellular location: Nucleus
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Sequence caution: Sequence=AAD38515.1; Type=Erroneous initiation;
Secondary accessions: Q6P4G9 Q7RTT1 Q96H01
Alternative splicing: 2 isoforms:  Q9Y5P8-1   Q9Y5P8-2   

Explore the universe of human proteins at neXtProt for PPP2R3B: NX_Q9Y5P8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5P8

    • PPP2R3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_037371.2  
    ENSEMBL proteins: 
     ENSP00000375080   ENSP00000371038  
    Reactome Protein details: Q9Y5P8
    Human Recombinant Protein Products: 
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    Novus Biologicals PPP2R3B Proteins
    Novus Biologicals PPP2R3B Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex ISS--
    GO:0005634nucleus TAS10629059
    GO:0005654nucleoplasm TAS--


    PPP2R3B for ontologies           About GeneDecksing



    PPP2R3B Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PPP2R3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPP2R3B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9Y5P8

    ProtoNet protein and cluster: Q9Y5P8

    UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8
    Similarity: Contains 1 EF-hand domain


    Function
    for PPP2R3B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: P2R3B_HUMAN, Q9Y5P8
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct
    the localization of the catalytic enzyme to a particular subcellular compartment

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: PPP2R3B 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: PPP2R3B
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PPP2R3B

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R3B

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity ISS--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI9847399
    GO:0008601protein phosphatase type 2A regulator activity TAS10629059


    PPP2R3B for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PPP2R3B:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 


    Pathways & Interactions
    for PPP2R3B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    2Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    		Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling1.00
    		Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling0.98
    3Cell cycle Regulation of G1/S transition (part 1)
    		Cell cycle Regulation of G1/S transition (part 1)1.00
    		Cell cycle_Regulation of G1/S transition (part 1)0.98
    4G1/S Transition
    		G1/S Transition1.00
    		Mitotic G1-G1/S phases0.80
    5Cyclins and Cell Cycle Regulation
    		G1 Phase0.32
    		Cyclin D associated events in G10.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PPP2R3B
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Signal transduction PKA signaling


    4 GeneGo (Thomson Reuters) Pathways for PPP2R3B
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    4 BioSystems Pathways for PPP2R3B 
        Glycogen Metabolism
    Wnt Signaling Pathway and Pluripotency
    IL-6 Signaling Pathway
    Regulation of retinoblastoma protein

    5/8        Reactome Pathways for PPP2R3B (see all 8)
        G1 Phase
    Mitotic G1-G1/S phases
    Inhibition of replication initiation of damaged DNA by RB1/E2F1
    Cell Cycle
    E2F mediated regulation of DNA replication


    1         Kegg Pathway  (Kegg details for PPP2R3B):
        mRNA surveillance pathway


    PPP2R3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP2R3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for PPP2R3B (Q9Y5P83 ENSP000003750804) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301533, ENSP000003248044I2D: score=4 STRING: ENSP00000324804
    CDC6Q997413, ENSP000002097284I2D: score=3 STRING: ENSP00000209728
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PPP2R1BP301543, ENSP000003113444I2D: score=1 STRING: ENSP00000311344
    PPP2CAP677753, ENSP000004184474I2D: score=2 STRING: ENSP00000418447
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006470protein dephosphorylation ISS--
    GO:0007050cell cycle arrest TAS10629059


    PPP2R3B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPP2R3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PPP2R3B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PPP2R3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CantharidinProtein phosphatase 1 and 2A inhibitor[56-25-7]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]
    Fostriecin sodium saltPotent PP2A and PP4 inhibitor[87860-39-7]

    3 HMDB Compounds for PPP2R3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about PPP2R3B / P2R3B 

    Transcripts
    for PPP2R3B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPP2R3B gene (2 alternative transcripts): 
    NM_013239.4  NM_199326.1  

    Unigene Cluster for PPP2R3B:

    Protein phosphatase 2, regulatory subunit B'', beta
    Hs.124942  [show with all ESTs]
    Unigene Representative Sequence: AB209137
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390665(uc004cpf.3 uc004cpg.3) ENST00000479438 ENST00000477110
    ENST00000468169 ENST00000484364 ENST00000477636 ENST00000445792(uc011mha.2)
    ENST00000496630 ENST00000475859 ENST00000381625

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: PPP2R3B 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209137.1 AF135016.1 AF155098.1 AK293506.1 BC011180.1 BC063429.1 

    18 DOTS entries:

    DT.101977903  DT.109191  DT.100814348  DT.100814351  DT.75167033  DT.99973164  DT.75181625  DT.91987873 
    DT.100708521  DT.95268121  DT.100814349  DT.100814350  DT.120650983  DT.120650987  DT.121305106  DT.121305116 
    DT.70101738  DT.75189514 

    24/94 AceView cDNA sequences (see all 94):

    BF058956 BU621602 AI797466 BQ070728 BQ889485 BQ574899 NM_199326 BM714230 
    NM_013239 BX282407 BK000521 BM711041 BM715684 AW071964 BQ051062 AI400617 
    AL157501 AL555389 BX355787 BM928753 BQ645650 BV205376 AL583511 AF135016 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3B (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                  -                       -                                             
    SP2:                                                                                                                        
    SP3:        -                                                                                                               
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for PPP2R3B

    Expression
    for PPP2R3B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP2R3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGGGACGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PPP2R3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP2R3B

    SOURCE GeneReport for Unigene cluster: Hs.124942
        SABiosciences Custom PCR Arrays for PPP2R3B
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R3B

    Orthologs
    for PPP2R3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R3B gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PPP2R3B1 protein phosphatase 2, regulatory subunit B'', beta 67.89(n)
    75.87(a)    		   418670  XM_416866.3  XP_416866.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PPP2R3B6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 3(112270239-112310535)
    zebrafish
    (Danio rerio)    		 Actinopterygii ppp2r3b1 protein phosphatase 2, regulatory subunit B'', beta 65.19(n)
    66.67(a)    		   566032  XM_689298.5  XP_694390.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG47331 CG4733 63.35(n)
    57.96(a)    		   42368  NM_142585.3  NP_650842.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea C06G1.51 Protein C06G1.5 47.94(n)
    40.35(a)    		   181721  NM_078289.3  NP_510690.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G544501 calcium-binding EF-hand-containing protein 46.75(n)
    41.06(a)    		   841887  NM_104323.3  NP_175847.1 
    rice
    (Oryza sativa)    		 Liliopsida Os10g04766001 hypothetical protein 47.58(n)
    39.31(a)    		   4348893  NM_001071385.1  NP_001064850.1 


    ENSEMBL Gene Tree for PPP2R3B (if available)
    TreeFam Gene Tree for PPP2R3B (if available) 

    Paralogs
    for PPP2R3B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP2R3B gene
    PPP2R3A2  PPP2R3C2  
    2 SIMAP similar genes for PPP2R3B using alignment to 3 protein entries:     P2R3B_HUMAN (see all proteins):
    DKFZp434G155    PPP2R3A

    PPP2R3B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PPP2R3B
    PGOHUM00000248820 PGOHUM00000248834


    Genomic Variants
    for PPP2R3B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PPP2R3B
         2 CNVs: 4141 73888
         1 Indel: 73887
    Locus Specific Mutation Databases (LSDB): PPP2R3B
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP2R3B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R3B

    Disorders / Diseases
    for PPP2R3B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPP2R3B for disorders           About GeneDecksing

    OMIM gene information: 300339    OMIM disorders: --

    8 diseases for PPP2R3B:    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    patau syndrome
    renal cell carcinoma    cerebritis    carcinoma    malaria


    Export disorders for PPP2R3B gene to outside databases

    Publications
    for PPP2R3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP2R3B gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PPP2R3B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with cdc6 and modulates DNA replication in human cells. (PubMed id 10629059)1, 2, 9 Yan Z.... Williams R.S. (2000)
    2. Identification and characterization of B''-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. (PubMed id 12605688)1, 2 Stevens I....Van Hoof C. (2003)
    3. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. (PubMed id 11173861)1, 3 Schiebel K....Rappold G. (2000)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1 Goudreault M....Gingras A.C. (2009)
    6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for PPP2R3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPP2R3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28227 HGNC: 13417 AceView: PR48 Ensembl:ENSG00000167393 euGenes: HUgn28227
    ECgene: PPP2R3B Kegg: 28227 H-InvDB: PPP2R3B

    Other Databases showing PPP2R3B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPP2R3B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP2R3B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PPP2R3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPP2R3B gene:
    Search GeneIP for patents involving PPP2R3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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