Aliases for PPP2R3A Gene
- Protein Phosphatase 2 Regulatory Subunit B''Alpha 2
- Protein Phosphatase 2 Regulatory Subunit Balpha 2 3 5
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 72), Alpha Isoform And (PR 130), Beta Isoform 2 3
- Serine/Threonine-Protein Phosphatase 2A 72/130 KDa Regulatory Subunit B 3 4
- PP2A Subunit B Isoforms B72/B130 3 4
- PPP2R3 3 4
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Alpha 3
- Protein Phosphatase 2, Regulatory Subunit B, Alpha 3
External Ids for PPP2R3A Gene
Previous HGNC Symbols for PPP2R3A Gene
Previous GeneCards Identifiers for PPP2R3A Gene
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
GeneCards Summary for PPP2R3A Gene
PPP2R3A (Protein Phosphatase 2 Regulatory Subunit B''Alpha) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Reelin Pathway (Cajal-Retzius cells). GO annotations related to this gene include calcium ion binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R3B.
UniProtKB/Swiss-Prot for PPP2R3A Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.