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Aliases for PPP2R3A Gene

Aliases for PPP2R3A Gene

  • Protein Phosphatase 2 Regulatory Subunit B'', Alpha 2
  • Protein Phosphatase 2 Regulatory Subunit B, Alpha 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 72), Alpha Isoform And (PR 130), Beta Isoform 2 3
  • Serine/Threonine-Protein Phosphatase 2A 72/130 KDa Regulatory Subunit B 3 4
  • Protein Phosphatase 2, Regulatory Subunit B, Alpha 2 3
  • PP2A Subunit B Isoforms B72/B130 3 4
  • PPP2R3 3 4
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Alpha 2
  • PP2A Subunit B Isoforms B-PR72/PR130 4
  • PP2A Subunit B Isoform PR72/PR130 4
  • PP2A Subunit B Isoform R3 Isoform 4
  • PP2A, Subunit B, R3 Isoform 3
  • PR130 3
  • PR72 3

External Ids for PPP2R3A Gene

Previous HGNC Symbols for PPP2R3A Gene

  • PPP2R3

Previous GeneCards Identifiers for PPP2R3A Gene

  • GC03P132624
  • GC03P136435
  • GC03P136966
  • GC03P137005
  • GC03P137167
  • GC03P135684
  • GC03P133062

Summaries for PPP2R3A Gene

Entrez Gene Summary for PPP2R3A Gene

  • This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

GeneCards Summary for PPP2R3A Gene

PPP2R3A (Protein Phosphatase 2 Regulatory Subunit B'', Alpha) is a Protein Coding gene. Among its related pathways are Sphingolipid signaling pathway and Beta-Adrenergic Signaling. GO annotations related to this gene include calcium ion binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R3C.

UniProtKB/Swiss-Prot for PPP2R3A Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Tocris Summary for PPP2R3A Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R3A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R3A Gene

Genomics for PPP2R3A Gene

Regulatory Elements for PPP2R3A Gene

Promoters for PPP2R3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2R3A on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2R3A Gene

Chromosome:
3
Start:
135,965,673 bp from pter
End:
136,147,910 bp from pter
Size:
182,238 bases
Orientation:
Plus strand

Genomic View for PPP2R3A Gene

Genes around PPP2R3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R3A Gene

Proteins for PPP2R3A Gene

  • Protein details for PPP2R3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06190-P2R3A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B subunit alpha
    Protein Accession:
    Q06190
    Secondary Accessions:
    • A8KAE7
    • B4DNU1
    • B7ZAE3
    • Q06189
    • Q9NPQ5

    Protein attributes for PPP2R3A Gene

    Size:
    1150 amino acids
    Molecular mass:
    130278 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

    Three dimensional structures from OCA and Proteopedia for PPP2R3A Gene

    Alternative splice isoforms for PPP2R3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R3A Gene

Proteomics data for PPP2R3A Gene at MOPED

Post-translational modifications for PPP2R3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP2R3A Gene

Antibody Products

No data available for DME Specific Peptides for PPP2R3A Gene

Domains & Families for PPP2R3A Gene

Protein Domains for PPP2R3A Gene

Graphical View of Domain Structure for InterPro Entry

Q06190

UniProtKB/Swiss-Prot:

P2R3A_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with PPP2R3A: view

Function for PPP2R3A Gene

Molecular function for PPP2R3A Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Gene Ontology (GO) - Molecular Function for PPP2R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PPP2R3A: view
genes like me logo Genes that share phenotypes with PPP2R3A: view

Animal Models for PPP2R3A Gene

MGI Knock Outs for PPP2R3A:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2R3A Gene

Localization for PPP2R3A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R3A Gene COMPARTMENTS Subcellular localization image for PPP2R3A gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP2R3A Gene

Pathways & Interactions for PPP2R3A Gene

genes like me logo Genes that share pathways with PPP2R3A: view

Gene Ontology (GO) - Biological Process for PPP2R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001754 eye photoreceptor cell differentiation IGI 15687260
GO:0006470 protein dephosphorylation ISS 1849734
GO:0007525 somatic muscle development IGI 15687260
GO:0034047 regulation of protein phosphatase type 2A activity TAS 8392071
GO:0061053 somite development ISS 16567647
genes like me logo Genes that share ontologies with PPP2R3A: view

No data available for SIGNOR curated interactions for PPP2R3A Gene

Drugs & Compounds for PPP2R3A Gene

(3) Drugs for PPP2R3A Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPP2R3A Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ceramide
3102-57-6
DL-AP3
20263-06-3

(5) Tocris Compounds for PPP2R3A Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
genes like me logo Genes that share compounds with PPP2R3A: view

Transcripts for PPP2R3A Gene

Unigene Clusters for PPP2R3A Gene

Protein phosphatase 2, regulatory subunit B, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3A Gene

No ASD Table

Relevant External Links for PPP2R3A Gene

GeneLoc Exon Structure for
PPP2R3A
ECgene alternative splicing isoforms for
PPP2R3A

Expression for PPP2R3A Gene

mRNA expression in normal human tissues for PPP2R3A Gene

mRNA differential expression in normal tissues according to GTEx for PPP2R3A Gene

This gene is overexpressed in Muscle - Skeletal (x6.6) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for PPP2R3A Gene

This gene is overexpressed in Neutrophil (20.0), Adrenal (18.8), Peripheral blood mononuclear cells (16.0), and Platelet (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R3A Gene



SOURCE GeneReport for Unigene cluster for PPP2R3A Gene Hs.518155

mRNA Expression by UniProt/SwissProt for PPP2R3A Gene

Q06190-P2R3A_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, muscle and kidney.
genes like me logo Genes that share expression patterns with PPP2R3A: view

Protein tissue co-expression partners for PPP2R3A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPP2R3A Gene

Orthologs for PPP2R3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC787607 35
  • 91.04 (n)
  • 90.17 (a)
PPP2R3A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R3A 35
  • 91.88 (n)
  • 90.69 (a)
PPP2R3A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r3a 35
  • 87.5 (n)
  • 85.79 (a)
Ppp2r3a 16
Ppp2r3a 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R3A 35
  • 99.71 (n)
  • 99.57 (a)
PPP2R3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r3a 35
  • 87.27 (n)
  • 85.35 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R3A 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R3A 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R3A 35
  • 68.28 (n)
  • 64.12 (a)
PPP2R3A 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R3A 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r3a 35
  • 73.02 (n)
  • 77.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398609 35
zebrafish
(Danio rerio)
Actinopterygii LOC565849 35
  • 60.96 (n)
  • 58.83 (a)
ppp2r3a 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4733 37
  • 58 (a)
CG4733 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G1.5 37
  • 38 (a)
C06G1.5 35
  • 50.6 (n)
  • 39.03 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G28900 35
  • 54.21 (n)
  • 44.7 (a)
rice
(Oryza sativa)
Liliopsida Os10g0476600 35
  • 52.33 (n)
  • 45.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1843 36
  • 57 (a)
OneToMany
Species with no ortholog for PPP2R3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R3A Gene

ENSEMBL:
Gene Tree for PPP2R3A (if available)
TreeFam:
Gene Tree for PPP2R3A (if available)

Paralogs for PPP2R3A Gene

Paralogs for PPP2R3A Gene

(2) SIMAP similar genes for PPP2R3A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP2R3A: view

Variants for PPP2R3A Gene

Sequence variations from dbSNP and Humsavar for PPP2R3A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs16843645 - 136,027,069(+) AAGCA(A/G)ACATT reference, missense
rs9814557 - 136,001,698(+) TGCAG(A/G)TCTGA intron-variant, reference, missense
rs36020282 - 136,001,821(-) TTAAG(C/T)TGTAG intron-variant, reference, missense
rs6779903 - 136,002,009(+) GGAAC(G/T)CCCCA intron-variant, reference, missense
rs34901937 - 136,002,939(+) CTTAG(C/G)TAGAT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PPP2R3A Gene

Variant ID Type Subtype PubMed ID
nsv460860 CNV Gain 19166990
nsv829732 CNV Gain 17160897
esv2669411 CNV Deletion 23128226
esv2421767 CNV Deletion 20811451
nsv4023 CNV Loss 18451855
nsv877518 CNV Loss 21882294
nsv4024 CNV Insertion 18451855

Variation tolerance for PPP2R3A Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.39; 92.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R3A Gene

HapMap Linkage Disequilibrium report
PPP2R3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R3A Gene

Disorders for PPP2R3A Gene

Relevant External Links for PPP2R3A

Genetic Association Database (GAD)
PPP2R3A
Human Genome Epidemiology (HuGE) Navigator
PPP2R3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R3A

No disorders were found for PPP2R3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R3A Gene

Publications for PPP2R3A Gene

  1. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. (PMID: 8392071) Hendrix P. … Hemmings B.A. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. (PMID: 18715506) Zwaenepoel K. … Janssens V. (BMC Genomics 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes. (PMID: 23287597) Comandini A. … Franzese O. (Mol. Immunol. 2013) 3

Products for PPP2R3A Gene

Sources for PPP2R3A Gene

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