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Aliases for PPP2R2D Gene

Aliases for PPP2R2D Gene

  • Protein Phosphatase 2 Regulatory Subunit Bdelta 2 3 5
  • PP2A Subunit B Isoform Delta 2 3 4
  • Protein Phosphatase 2, Regulatory Subunit B, Delta Isoform 2 3
  • PP2A Subunit B Isoform PR55-Delta 3 4
  • PP2A Subunit B Isoform B55-Delta 3 4
  • PP2A Subunit B Isoform R2-Delta 3 4
  • Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Delta Isoform 3
  • Protein Phosphatase 2 Regulatory Subunit B, Delta 3
  • KIAA1541 4
  • MDS026 3

External Ids for PPP2R2D Gene

Previous GeneCards Identifiers for PPP2R2D Gene

  • GC10P133182
  • GC10P133597
  • GC10U900627
  • GC10P133747
  • GC10P127299

Summaries for PPP2R2D Gene

GeneCards Summary for PPP2R2D Gene

PPP2R2D (Protein Phosphatase 2 Regulatory Subunit Bdelta) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Tight junction. An important paralog of this gene is PPP2R2A.

UniProtKB/Swiss-Prot for PPP2R2D Gene

  • B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Tocris Summary for PPP2R2D Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2D Gene

Genomics for PPP2R2D Gene

Regulatory Elements for PPP2R2D Gene

Enhancers for PPP2R2D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F131944 0.9 Ensembl ENCODE 33.3 +46.6 46589 4.9 CTCF JUND JUN BHLHE40 MAX FOS MYC PPP2R2D BNIP3 JAKMIP3 ENSG00000277959
GH10F131983 0.5 ENCODE 19.2 +83.1 83122 1.2 PKNOX1 SAP130 MAFG ZNF316 GATA3 MAFF ZBTB33 FOSL2 FOS EMSY PPP2R2D BNIP3 ENSG00000279982
GH10F131926 1.1 Ensembl ENCODE 18.4 +27.7 27657 3.4 ZIC2 ZFHX2 ZNF316 ZBTB48 EGR1 NFE2 MAFK EGR2 NFE2L2 ZNF202 PPP2R2D ENSG00000277959
GH10F131930 0.2 Ensembl 18.4 +30.7 30657 2.2 KLF1 POLR2A SCRT2 PPP2R2D ENSG00000277959
GH10F131920 0.8 Ensembl ENCODE 18.3 +20.5 20457 1.0 ZNF263 WRNIP1 ZNF121 ZBTB48 KDM1A MLLT1 CREM EGR2 PPP2R2D ENSG00000277959
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPP2R2D on UCSC Golden Path with GeneCards custom track

Promoters for PPP2R2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001765435 557 2800

Genomic Location for PPP2R2D Gene

Chromosome:
10
Start:
131,900,644 bp from pter
End:
131,969,980 bp from pter
Size:
69,337 bases
Orientation:
Plus strand

Genomic View for PPP2R2D Gene

Genes around PPP2R2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2D Gene

Proteins for PPP2R2D Gene

  • Protein details for PPP2R2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66LE6-2ABD_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
    Protein Accession:
    Q66LE6
    Secondary Accessions:
    • A8KAK0
    • Q5SQJ2
    • Q9P1Y7

    Protein attributes for PPP2R2D Gene

    Size:
    453 amino acids
    Molecular mass:
    52042 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at Ser-67) and ARPP19 (when phosphorylated at Ser-62), leading to inhibit PP2A activity (By similarity).
    SequenceCaution:
    • Sequence=BAA96065.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16703.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PPP2R2D Gene

Post-translational modifications for PPP2R2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP2R2D Gene

Domains & Families for PPP2R2D Gene

Graphical View of Domain Structure for InterPro Entry

Q66LE6

UniProtKB/Swiss-Prot:

2ABD_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PPP2R2D: view

Function for PPP2R2D Gene

Molecular function for PPP2R2D Gene

UniProtKB/Swiss-Prot Function:
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Gene Ontology (GO) - Molecular Function for PPP2R2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 contributes_to protein serine/threonine phosphatase activity IBA --
GO:0019888 protein phosphatase regulator activity ISS --
genes like me logo Genes that share ontologies with PPP2R2D: view
genes like me logo Genes that share phenotypes with PPP2R2D: view

Animal Model Products

miRNA for PPP2R2D Gene

miRTarBase miRNAs that target PPP2R2D

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2D Gene

Localization for PPP2R2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R2D Gene COMPARTMENTS Subcellular localization image for PPP2R2D gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP2R2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with PPP2R2D: view

Pathways & Interactions for PPP2R2D Gene

genes like me logo Genes that share pathways with PPP2R2D: view

Gene Ontology (GO) - Biological Process for PPP2R2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division ISS --
GO:0010458 exit from mitosis ISS --
GO:0032502 developmental process IBA --
genes like me logo Genes that share ontologies with PPP2R2D: view

No data available for SIGNOR curated interactions for PPP2R2D Gene

Drugs & Compounds for PPP2R2D Gene

(4) Drugs for PPP2R2D Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 915
Calyculin A Experimental Pharma Protein phosphatase inhibitor, Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 inhibitor, Protein phosphatase 1 and 2A inhibitor 0
Tautomycetin Pharma Selective PP1 inhibitor 0

(1) Additional Compounds for PPP2R2D Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506
104987-11-3

(5) Tocris Compounds for PPP2R2D Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
Tautomycetin Selective PP1 inhibitor 119757-73-2
genes like me logo Genes that share compounds with PPP2R2D: view

Transcripts for PPP2R2D Gene

mRNA/cDNA for PPP2R2D Gene

(8) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP2R2D Gene

Protein phosphatase 2, regulatory subunit B, delta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2D Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for PPP2R2D Gene

GeneLoc Exon Structure for
PPP2R2D
ECgene alternative splicing isoforms for
PPP2R2D

Expression for PPP2R2D Gene

mRNA expression in normal human tissues for PPP2R2D Gene

Protein differential expression in normal tissues from HIPED for PPP2R2D Gene

This gene is overexpressed in Saliva (29.4) and Heart (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP2R2D Gene



NURSA nuclear receptor signaling pathways regulating expression of PPP2R2D Gene:

PPP2R2D

SOURCE GeneReport for Unigene cluster for PPP2R2D Gene:

Hs.380372
genes like me logo Genes that share expression patterns with PPP2R2D: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PPP2R2D Gene

Orthologs for PPP2R2D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R2D 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R2D 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R2D 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R2D 34 35
  • 90.84 (n)
mouse
(Mus musculus)
Mammalia Ppp2r2d 34 16 35
  • 89.92 (n)
rat
(Rattus norvegicus)
Mammalia Ppp2r2d 34
  • 89.55 (n)
chicken
(Gallus gallus)
Aves PPP2R2D 34 35
  • 84.7 (n)
lizard
(Anolis carolinensis)
Reptilia PPP2R2D 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2d 34
  • 81.67 (n)
zebrafish
(Danio rerio)
Actinopterygii ppp2r2d 35
  • 89 (a)
OneToOne
ppp2r2bb 34
  • 75.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004502 34
  • 68.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta tws 34 35
  • 68.66 (n)
worm
(Caenorhabditis elegans)
Secernentea sur-6 34 35
  • 59.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 34 35
  • 59.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR195W 34
  • 55.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09053g 34
  • 54.82 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATB BETA 34
  • 58.81 (n)
rice
(Oryza sativa)
Liliopsida Os06g0563300 34
  • 58.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 35
  • 68 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pab1 34
  • 59.1 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09377 34
  • 58.61 (n)
Species where no ortholog for PPP2R2D was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R2D Gene

ENSEMBL:
Gene Tree for PPP2R2D (if available)
TreeFam:
Gene Tree for PPP2R2D (if available)

Paralogs for PPP2R2D Gene

Paralogs for PPP2R2D Gene

(3) SIMAP similar genes for PPP2R2D Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PPP2R2D Gene

genes like me logo Genes that share paralogs with PPP2R2D: view

Variants for PPP2R2D Gene

Sequence variations from dbSNP and Humsavar for PPP2R2D Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10128358 -- 131,966,992(+) TCTCC(G/T)GCCTC intron-variant
rs10159746 -- 131,929,173(+) GTCTC(C/T)TGTGC intron-variant
rs10159943 -- 131,931,240(+) AAGCA(C/T)TCAGC intron-variant
rs10223 -- 131,970,748(-) ACCCT(A/C)AGCAT reference, synonymous-codon, utr-variant-3-prime
rs10430614 -- 131,935,136(+) GGCAC(C/T)GCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2D Gene

Variant ID Type Subtype PubMed ID
dgv114e201 CNV deletion 23290073
dgv990n100 CNV gain 25217958
esv1109336 CNV deletion 17803354
esv1295798 CNV insertion 17803354
esv1363864 CNV deletion 17803354
esv22692 CNV loss 19812545
esv23461 CNV gain+loss 19812545
esv2741103 CNV deletion 23290073
esv2741222 CNV deletion 23290073
esv2743582 CNV deletion 23290073
esv2743583 CNV deletion 23290073
esv2743584 CNV deletion 23290073
esv2743589 CNV deletion 23290073
esv2743590 CNV deletion 23290073
esv2743591 CNV deletion 23290073
esv2743592 CNV deletion 23290073
esv2743593 CNV deletion 23290073
esv2743594 CNV deletion 23290073
esv3624956 CNV gain 21293372
esv3624979 CNV gain 21293372
esv5340 CNV loss 18987735
nsv1054934 CNV gain 25217958
nsv1069978 CNV deletion 25765185
nsv1076369 CNV duplication 25765185
nsv1139536 CNV duplication 24896259
nsv1140118 CNV insertion 24896259
nsv1147568 CNV deletion 26484159
nsv472371 CNV novel sequence insertion 20440878
nsv473171 CNV novel sequence insertion 20440878
nsv473596 CNV novel sequence insertion 20440878
nsv473905 CNV novel sequence insertion 20440878
nsv474396 CNV novel sequence insertion 20440878
nsv474452 CNV novel sequence insertion 20440878
nsv475028 CNV novel sequence insertion 20440878
nsv475897 CNV novel sequence insertion 20440878
nsv475918 CNV novel sequence insertion 20440878
nsv477563 CNV novel sequence insertion 20440878
nsv478039 CNV novel sequence insertion 20440878
nsv478182 CNV novel sequence insertion 20440878
nsv479145 CNV novel sequence insertion 20440878
nsv479146 CNV novel sequence insertion 20440878
nsv479497 CNV novel sequence insertion 20440878
nsv479528 CNV novel sequence insertion 20440878
nsv479541 CNV novel sequence insertion 20440878
nsv479546 CNV novel sequence insertion 20440878
nsv479751 CNV novel sequence insertion 20440878
nsv479850 CNV novel sequence insertion 20440878
nsv479864 CNV novel sequence insertion 20440878
nsv480362 CNV novel sequence insertion 20440878
nsv480758 CNV novel sequence insertion 20440878
nsv480795 CNV novel sequence insertion 20440878
nsv480988 CNV novel sequence insertion 20440878
nsv481025 CNV novel sequence insertion 20440878
nsv481040 CNV novel sequence insertion 20440878
nsv481216 CNV novel sequence insertion 20440878
nsv481341 CNV novel sequence insertion 20440878
nsv481444 CNV novel sequence insertion 20440878
nsv481464 CNV novel sequence insertion 20440878
nsv481495 CNV novel sequence insertion 20440878
nsv481523 CNV novel sequence insertion 20440878
nsv481596 CNV novel sequence insertion 20440878
nsv518204 CNV gain 19592680
nsv825650 CNV gain 20364138
nsv8742 CNV loss 18304495
nsv8743 CNV loss 18304495
nsv8744 CNV gain 18304495
nsv956916 CNV deletion 24416366

Variation tolerance for PPP2R2D Gene

Gene Damage Index Score: 6.98; 79.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R2D Gene

Human Gene Mutation Database (HGMD)
PPP2R2D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2D Gene

Disorders for PPP2R2D Gene

Relevant External Links for PPP2R2D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R2D

No disorders were found for PPP2R2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2D Gene

Publications for PPP2R2D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for PPP2R2D Gene

Sources for PPP2R2D Gene

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