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Aliases for PPP2R2D Gene

Aliases for PPP2R2D Gene

  • Protein Phosphatase 2 Regulatory Subunit B, Delta 2 3 5
  • PP2A Subunit B Isoform Delta 2 3 4
  • Protein Phosphatase 2, Regulatory Subunit B, Delta Isoform 2 3
  • PP2A Subunit B Isoform PR55-Delta 3 4
  • PP2A Subunit B Isoform B55-Delta 3 4
  • PP2A Subunit B Isoform R2-Delta 3 4
  • Protein Phosphatase 2, Regulatory Subunit B, Delta 2
  • KIAA1541 4
  • MDS026 3

External Ids for PPP2R2D Gene

Previous GeneCards Identifiers for PPP2R2D Gene

  • GC10P133182
  • GC10P133597
  • GC10U900627
  • GC10P133747
  • GC10P127299

Summaries for PPP2R2D Gene

GeneCards Summary for PPP2R2D Gene

PPP2R2D (Protein Phosphatase 2 Regulatory Subunit B, Delta) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Cell Cycle, Mitotic. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2C.

UniProtKB/Swiss-Prot for PPP2R2D Gene

  • B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Tocris Summary for PPP2R2D Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2D Gene

Genomics for PPP2R2D Gene

Regulatory Elements for PPP2R2D Gene

Promoters for PPP2R2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2R2D on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2R2D Gene

Chromosome:
10
Start:
131,900,644 bp from pter
End:
131,969,980 bp from pter
Size:
69,337 bases
Orientation:
Plus strand

Genomic View for PPP2R2D Gene

Genes around PPP2R2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2D Gene

Proteins for PPP2R2D Gene

  • Protein details for PPP2R2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66LE6-2ABD_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
    Protein Accession:
    Q66LE6
    Secondary Accessions:
    • A8KAK0
    • Q5SQJ2
    • Q9P1Y7

    Protein attributes for PPP2R2D Gene

    Size:
    453 amino acids
    Molecular mass:
    52042 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at Ser-67) and ARPP19 (when phosphorylated at Ser-62), leading to inhibit PP2A activity (By similarity).
    SequenceCaution:
    • Sequence=BAA96065.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16703.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PPP2R2D Gene

Proteomics data for PPP2R2D Gene at MOPED

Post-translational modifications for PPP2R2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP2R2D Gene

Antibody Products

No data available for DME Specific Peptides for PPP2R2D Gene

Domains & Families for PPP2R2D Gene

Graphical View of Domain Structure for InterPro Entry

Q66LE6

UniProtKB/Swiss-Prot:

2ABD_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PPP2R2D: view

Function for PPP2R2D Gene

Molecular function for PPP2R2D Gene

UniProtKB/Swiss-Prot Function:
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
genes like me logo Genes that share phenotypes with PPP2R2D: view

Animal Model Products

miRNA for PPP2R2D Gene

miRTarBase miRNAs that target PPP2R2D

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2D Gene

Localization for PPP2R2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R2D Gene COMPARTMENTS Subcellular localization image for PPP2R2D gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PPP2R2D Gene

Pathways & Interactions for PPP2R2D Gene

genes like me logo Genes that share pathways with PPP2R2D: view

Gene Ontology (GO) - Biological Process for PPP2R2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0010458 exit from mitosis ISS --
GO:0034047 regulation of protein phosphatase type 2A activity IEA,ISS --
genes like me logo Genes that share ontologies with PPP2R2D: view

No data available for SIGNOR curated interactions for PPP2R2D Gene

Drugs & Compounds for PPP2R2D Gene

(3) Drugs for PPP2R2D Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPP2R2D Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ceramide
3102-57-6
DL-AP3
20263-06-3
genes like me logo Genes that share compounds with PPP2R2D: view

Transcripts for PPP2R2D Gene

mRNA/cDNA for PPP2R2D Gene

(8) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP2R2D Gene

Protein phosphatase 2, regulatory subunit B, delta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2D Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for PPP2R2D Gene

GeneLoc Exon Structure for
PPP2R2D
ECgene alternative splicing isoforms for
PPP2R2D

Expression for PPP2R2D Gene

mRNA expression in normal human tissues for PPP2R2D Gene

Protein differential expression in normal tissues from HIPED for PPP2R2D Gene

This gene is overexpressed in Saliva (29.4) and Heart (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R2D Gene



SOURCE GeneReport for Unigene cluster for PPP2R2D Gene Hs.380372

genes like me logo Genes that share expression patterns with PPP2R2D: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPP2R2D Gene

Orthologs for PPP2R2D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R2D 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R2D 35
  • 90.84 (n)
  • 96.68 (a)
PPP2R2D 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r2d 16
Ppp2r2d 35
  • 89.92 (n)
  • 97.27 (a)
Ppp2r2d 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R2D 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R2D 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r2d 35
  • 89.55 (n)
  • 97.05 (a)
chicken
(Gallus gallus)
Aves PPP2R2D 36
  • 90 (a)
OneToOne
PPP2R2D 35
  • 84.7 (n)
  • 96.59 (a)
lizard
(Anolis carolinensis)
Reptilia PPP2R2D 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2d 35
  • 81.67 (n)
  • 96.36 (a)
zebrafish
(Danio rerio)
Actinopterygii ppp2r2bb 35
  • 75.57 (n)
  • 87.71 (a)
ppp2r2d 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004502 35
  • 68.74 (n)
  • 81.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta tws 36
  • 67 (a)
OneToMany
tws 35
  • 68.66 (n)
  • 79.72 (a)
worm
(Caenorhabditis elegans)
Secernentea sur-6 36
  • 58 (a)
OneToMany
sur-6 35
  • 59.94 (n)
  • 68.68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR195W 35
  • 55.58 (n)
  • 56.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 35
  • 59.19 (n)
  • 60.82 (a)
CDC55 36
  • 45 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09053g 35
  • 54.82 (n)
  • 57.11 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATB BETA 35
  • 58.81 (n)
  • 57.51 (a)
rice
(Oryza sativa)
Liliopsida Os06g0563300 35
  • 58.74 (n)
  • 59.58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09377 35
  • 58.61 (n)
  • 62.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pab1 35
  • 59.1 (n)
  • 61.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 36
  • 68 (a)
OneToMany
Species with no ortholog for PPP2R2D:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R2D Gene

ENSEMBL:
Gene Tree for PPP2R2D (if available)
TreeFam:
Gene Tree for PPP2R2D (if available)

Paralogs for PPP2R2D Gene

Paralogs for PPP2R2D Gene

(3) SIMAP similar genes for PPP2R2D Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PPP2R2D Gene

genes like me logo Genes that share paralogs with PPP2R2D: view

Variants for PPP2R2D Gene

Sequence variations from dbSNP and Humsavar for PPP2R2D Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs34473884 - 131,947,781(+) GGAAC(A/C/G)GTTCG nc-transcript-variant, reference, missense
rs7894 -- 131,955,978(-) TGGTC(C/G)TCACG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs4364981 -- 131,939,643(+) CATTC(A/G)GCAGA intron-variant, upstream-variant-2KB
rs4372367 -- 131,944,258(+) CCATC(A/G)CTGCA intron-variant
rs4342945 -- 131,938,153(+) CACAT(C/T)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2D Gene

Variant ID Type Subtype PubMed ID
nsv518204 CNV Gain 19592680
nsv896117 CNV Loss 21882294
nsv825650 CNV Gain 20364138
nsv8743 CNV Loss 18304495
esv2743584 CNV Deletion 23290073
esv1295798 CNV Insertion 17803354
dgv133e201 CNV Deletion 23290073
esv5340 CNV Deletion 18987735
esv2743589 CNV Deletion 23290073
esv22692 CNV Loss 19812545
esv2743590 CNV Deletion 23290073
esv1363864 CNV Deletion 17803354
esv2741103 CNV Deletion 23290073
esv1109336 CNV Deletion 17803354
esv2741222 CNV Deletion 23290073
esv2743591 CNV Deletion 23290073
esv2743592 CNV Deletion 23290073

Variation tolerance for PPP2R2D Gene

Gene Damage Index Score: 6.98; 79.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R2D Gene

HapMap Linkage Disequilibrium report
PPP2R2D
Human Gene Mutation Database (HGMD)
PPP2R2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2D Gene

Disorders for PPP2R2D Gene

Relevant External Links for PPP2R2D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R2D

No disorders were found for PPP2R2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2D Gene

Publications for PPP2R2D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. An in vivo screen implicates PPP2R2D as an inhibitor of T-cell function. (PMID: 24596207) (Cancer Discov 2014) 3
  5. GSK3I^ controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. (PMID: 23851495) Kao S.H. … Yang P.C. (Oncogene 2014) 3

Products for PPP2R2D Gene

Sources for PPP2R2D Gene

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