Aliases for PPP2R2D Gene
External Ids for PPP2R2D Gene
Previous GeneCards Identifiers for PPP2R2D Gene
GeneCards Summary for PPP2R2D Gene
PPP2R2D (Protein Phosphatase 2, Regulatory Subunit B, Delta) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Cell Cycle, Mitotic. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2C.
UniProtKB/Swiss-Prot for PPP2R2D Gene
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.