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Aliases for PPP2R2D Gene

Aliases for PPP2R2D Gene

  • Protein Phosphatase 2 Regulatory Subunit Bdelta 2 3 5
  • PP2A Subunit B Isoform Delta 2 3 4
  • Protein Phosphatase 2, Regulatory Subunit B, Delta Isoform 2 3
  • PP2A Subunit B Isoform PR55-Delta 3 4
  • PP2A Subunit B Isoform B55-Delta 3 4
  • PP2A Subunit B Isoform R2-Delta 3 4
  • Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Delta Isoform 3
  • Protein Phosphatase 2 Regulatory Subunit B, Delta 3
  • B55delta 3
  • KIAA1541 4
  • MDS026 3
  • B55D 3

External Ids for PPP2R2D Gene

Previous GeneCards Identifiers for PPP2R2D Gene

  • GC10P133182
  • GC10P133597
  • GC10U900627
  • GC10P133747
  • GC10P127299

Summaries for PPP2R2D Gene

GeneCards Summary for PPP2R2D Gene

PPP2R2D (Protein Phosphatase 2 Regulatory Subunit Bdelta) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Toll-like receptor signaling pathway. An important paralog of this gene is PPP2R2A.

UniProtKB/Swiss-Prot for PPP2R2D Gene

  • B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Tocris Summary for PPP2R2D Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Additional gene information for PPP2R2D Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2D Gene

Genomics for PPP2R2D Gene

GeneHancer (GH) Regulatory Elements for PPP2R2D Gene

Promoters and enhancers for PPP2R2D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I131900 Promoter 0.5 Ensembl 550.8 +0.6 557 2.4 PPP2R2D ENSG00000277959
GH10I131944 Enhancer 0.9 Ensembl ENCODE dbSUPER 33.4 +46.6 46588 4.9 SP1 JUND JUN MAX FOSL2 FOS MYC PPP2R2D BNIP3 JAKMIP3 ENSG00000277959
GH10I132392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +507.8 507758 32.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZBTB7B PWWP2B TUBGCP2 ENSG00000235245 C10orf91 ZNF511 STK32C LOC105378568 PAOX PPP2R2D MTG1
GH10I131977 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.1 +79.7 79710 5.5 CLOCK FOXA2 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 ZNF121 BNIP3 ENSG00000273521 PPP2R2D
GH10I131961 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.1 +61.6 61581 1.5 HDAC1 ZBTB40 GATA2 POLR3A EGR1 RCOR1 ATF7 USF2 REST MYNN PPP2R2D ENSG00000277959
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP2R2D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R2D gene promoter:

Genomic Locations for PPP2R2D Gene

Genomic Locations for PPP2R2D Gene
chr10:131,900,644-131,969,980
(GRCh38/hg38)
Size:
69,337 bases
Orientation:
Plus strand
chr10:133,747,955-133,773,331
(GRCh37/hg19)

Genomic View for PPP2R2D Gene

Genes around PPP2R2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2D Gene

Proteins for PPP2R2D Gene

  • Protein details for PPP2R2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66LE6-2ABD_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
    Protein Accession:
    Q66LE6
    Secondary Accessions:
    • A8KAK0
    • Q5SQJ2
    • Q9P1Y7

    Protein attributes for PPP2R2D Gene

    Size:
    453 amino acids
    Molecular mass:
    52042 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at Ser-67) and ARPP19 (when phosphorylated at Ser-62), leading to inhibit PP2A activity (By similarity). Interacts with IER5 (PubMed:25816751).
    SequenceCaution:
    • Sequence=BAA96065.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16703.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PPP2R2D Gene

Post-translational modifications for PPP2R2D Gene

No Post-translational modifications

No data available for DME Specific Peptides for PPP2R2D Gene

Domains & Families for PPP2R2D Gene

Gene Families for PPP2R2D Gene

Graphical View of Domain Structure for InterPro Entry

Q66LE6

UniProtKB/Swiss-Prot:

2ABD_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B family.
genes like me logo Genes that share domains with PPP2R2D: view

Function for PPP2R2D Gene

Molecular function for PPP2R2D Gene

UniProtKB/Swiss-Prot Function:
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Phenotypes From GWAS Catalog for PPP2R2D Gene

Gene Ontology (GO) - Molecular Function for PPP2R2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 contributes_to protein serine/threonine phosphatase activity IBA --
GO:0005515 protein binding IPI 25544563
GO:0019888 protein phosphatase regulator activity ISS,IEA --
genes like me logo Genes that share ontologies with PPP2R2D: view
genes like me logo Genes that share phenotypes with PPP2R2D: view

Animal Model Products

miRNA for PPP2R2D Gene

miRTarBase miRNAs that target PPP2R2D

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2D Gene

Localization for PPP2R2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R2D gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP2R2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with PPP2R2D: view

Pathways & Interactions for PPP2R2D Gene

genes like me logo Genes that share pathways with PPP2R2D: view

Gene Ontology (GO) - Biological Process for PPP2R2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA,ISS --
GO:0007049 cell cycle IEA --
GO:0010458 exit from mitosis ISS --
GO:0032502 developmental process IBA --
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP2R2D: view

No data available for SIGNOR curated interactions for PPP2R2D Gene

Drugs & Compounds for PPP2R2D Gene

(4) Drugs for PPP2R2D Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0

(1) Additional Compounds for PPP2R2D Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506
104987-11-3

(4) Tocris Compounds for PPP2R2D Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2R2D: view

Transcripts for PPP2R2D Gene

mRNA/cDNA for PPP2R2D Gene

(8) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP2R2D Gene

Protein phosphatase 2, regulatory subunit B, delta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2D Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for PPP2R2D Gene

GeneLoc Exon Structure for
PPP2R2D
ECgene alternative splicing isoforms for
PPP2R2D

Expression for PPP2R2D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R2D Gene

Protein differential expression in normal tissues from HIPED for PPP2R2D Gene

This gene is overexpressed in Saliva (29.4) and Heart (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP2R2D Gene



NURSA nuclear receptor signaling pathways regulating expression of PPP2R2D Gene:

PPP2R2D

SOURCE GeneReport for Unigene cluster for PPP2R2D Gene:

Hs.380372

Evidence on tissue expression from TISSUES for PPP2R2D Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with PPP2R2D: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R2D Gene

Orthologs for PPP2R2D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R2D 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R2D 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R2D 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R2D 33 34
  • 90.84 (n)
mouse
(Mus musculus)
Mammalia Ppp2r2d 33 16 34
  • 89.92 (n)
rat
(Rattus norvegicus)
Mammalia Ppp2r2d 33
  • 89.55 (n)
chicken
(Gallus gallus)
Aves PPP2R2D 33 34
  • 84.7 (n)
lizard
(Anolis carolinensis)
Reptilia PPP2R2D 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2d 33
  • 81.67 (n)
zebrafish
(Danio rerio)
Actinopterygii ppp2r2d 34
  • 89 (a)
OneToOne
ppp2r2bb 33
  • 75.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004502 33
  • 68.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta tws 33 34
  • 68.66 (n)
worm
(Caenorhabditis elegans)
Secernentea sur-6 33 34
  • 59.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 33 34
  • 59.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR195W 33
  • 55.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09053g 33
  • 54.82 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATB BETA 33
  • 58.81 (n)
rice
(Oryza sativa)
Liliopsida Os06g0563300 33
  • 58.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 34
  • 68 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pab1 33
  • 59.1 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09377 33
  • 58.61 (n)
Species where no ortholog for PPP2R2D was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R2D Gene

ENSEMBL:
Gene Tree for PPP2R2D (if available)
TreeFam:
Gene Tree for PPP2R2D (if available)

Paralogs for PPP2R2D Gene

Paralogs for PPP2R2D Gene

(3) SIMAP similar genes for PPP2R2D Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PPP2R2D Gene

genes like me logo Genes that share paralogs with PPP2R2D: view

Variants for PPP2R2D Gene

Sequence variations from dbSNP and Humsavar for PPP2R2D Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000028134 -- 131,933,980(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000029226 -- 131,946,827(+) C/G intron_variant
rs1000105926 -- 131,960,942(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000172600 -- 131,910,187(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000179267 -- 131,949,216(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2D Gene

Variant ID Type Subtype PubMed ID
dgv114e201 CNV deletion 23290073
dgv990n100 CNV gain 25217958
esv1109336 CNV deletion 17803354
esv1295798 CNV insertion 17803354
esv1363864 CNV deletion 17803354
esv22692 CNV loss 19812545
esv23461 CNV gain+loss 19812545
esv2741103 CNV deletion 23290073
esv2741222 CNV deletion 23290073
esv2743582 CNV deletion 23290073
esv2743583 CNV deletion 23290073
esv2743584 CNV deletion 23290073
esv2743589 CNV deletion 23290073
esv2743590 CNV deletion 23290073
esv2743591 CNV deletion 23290073
esv2743592 CNV deletion 23290073
esv2743593 CNV deletion 23290073
esv2743594 CNV deletion 23290073
esv3624956 CNV gain 21293372
esv3624979 CNV gain 21293372
esv5340 CNV loss 18987735
nsv1054934 CNV gain 25217958
nsv1069978 CNV deletion 25765185
nsv1076369 CNV duplication 25765185
nsv1139536 CNV duplication 24896259
nsv1140118 CNV insertion 24896259
nsv1147568 CNV deletion 26484159
nsv472371 CNV novel sequence insertion 20440878
nsv473171 CNV novel sequence insertion 20440878
nsv473596 CNV novel sequence insertion 20440878
nsv473905 CNV novel sequence insertion 20440878
nsv474396 CNV novel sequence insertion 20440878
nsv474452 CNV novel sequence insertion 20440878
nsv475028 CNV novel sequence insertion 20440878
nsv475897 CNV novel sequence insertion 20440878
nsv475918 CNV novel sequence insertion 20440878
nsv477563 CNV novel sequence insertion 20440878
nsv478039 CNV novel sequence insertion 20440878
nsv478182 CNV novel sequence insertion 20440878
nsv479145 CNV novel sequence insertion 20440878
nsv479146 CNV novel sequence insertion 20440878
nsv479497 CNV novel sequence insertion 20440878
nsv479528 CNV novel sequence insertion 20440878
nsv479541 CNV novel sequence insertion 20440878
nsv479546 CNV novel sequence insertion 20440878
nsv479751 CNV novel sequence insertion 20440878
nsv479850 CNV novel sequence insertion 20440878
nsv479864 CNV novel sequence insertion 20440878
nsv480362 CNV novel sequence insertion 20440878
nsv480758 CNV novel sequence insertion 20440878
nsv480795 CNV novel sequence insertion 20440878
nsv480988 CNV novel sequence insertion 20440878
nsv481025 CNV novel sequence insertion 20440878
nsv481040 CNV novel sequence insertion 20440878
nsv481216 CNV novel sequence insertion 20440878
nsv481341 CNV novel sequence insertion 20440878
nsv481444 CNV novel sequence insertion 20440878
nsv481464 CNV novel sequence insertion 20440878
nsv481495 CNV novel sequence insertion 20440878
nsv481523 CNV novel sequence insertion 20440878
nsv481596 CNV novel sequence insertion 20440878
nsv518204 CNV gain 19592680
nsv825650 CNV gain 20364138
nsv8742 CNV loss 18304495
nsv8743 CNV loss 18304495
nsv8744 CNV gain 18304495
nsv956916 CNV deletion 24416366

Variation tolerance for PPP2R2D Gene

Gene Damage Index Score: 6.98; 79.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R2D Gene

Human Gene Mutation Database (HGMD)
PPP2R2D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2D Gene

Disorders for PPP2R2D Gene

Additional Disease Information for PPP2R2D

No disorders were found for PPP2R2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2D Gene

Publications for PPP2R2D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y … Sakurai H (FEBS letters 2015) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PPP2R2D Gene

Sources for PPP2R2D Gene

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