Aliases for PPP2R2D Gene
- Protein Phosphatase 2 Regulatory Subunit B, Delta 2 3 5
- PP2A Subunit B Isoform Delta 2 3 4
- Protein Phosphatase 2, Regulatory Subunit B, Delta Isoform 2 3
- PP2A Subunit B Isoform PR55-Delta 3 4
- PP2A Subunit B Isoform B55-Delta 3 4
- PP2A Subunit B Isoform R2-Delta 3 4
- Protein Phosphatase 2, Regulatory Subunit B, Delta 2
- KIAA1541 4
- MDS026 3
External Ids for PPP2R2D Gene
Previous GeneCards Identifiers for PPP2R2D Gene
GeneCards Summary for PPP2R2D Gene
PPP2R2D (Protein Phosphatase 2 Regulatory Subunit B, Delta) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Cell Cycle, Mitotic. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2C.
UniProtKB/Swiss-Prot for PPP2R2D Gene
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.