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Aliases for PPP2R2C Gene

Aliases for PPP2R2C Gene

  • Protein Phosphatase 2, Regulatory Subunit B, Gamma 2 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Gamma Isoform 2 3
  • PP2A Subunit B Isoform Gamma 2 4
  • IMYPNO1 3 4
  • PR52 3 6
  • Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Gamma Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Gamma Isoform 2
  • Gamma Isoform Of Regulatory Subunit B55, Protein Phosphatase 2 3
  • Phosphoprotein Phosphatase 2A BR Gamma Regulatory Chain 3
  • Protein Phosphatase 2A1 B Gamma Subunit 3
  • PP2A, Subunit B, PR55-Gamma Isoform 3
  • PP2A, Subunit B, B55-Gamma Isoform 3
  • PP2A, Subunit B, R2-Gamma Isoform 3
  • PP2A Subunit B Isoform PR55-Gamma 4
  • PP2A, Subunit B, B-Gamma Isoform 3
  • PP2A Subunit B Isoform B55-Gamma 4
  • PP2A Subunit B Isoform R2-Gamma 4
  • B55-GAMMA 3
  • IMYPNO 3
  • PR55G 3

External Ids for PPP2R2C Gene

Summaries for PPP2R2C Gene

Entrez Gene Summary for PPP2R2C Gene

  • The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R2C Gene

PPP2R2C (Protein Phosphatase 2, Regulatory Subunit B, Gamma) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2A.

UniProtKB/Swiss-Prot for PPP2R2C Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Tocris Summary for PPP2R2C Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2R2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2C Gene

Genomics for PPP2R2C Gene

Genomic Location for PPP2R2C Gene

Start:
6,320,578 bp from pter
End:
6,563,600 bp from pter
Size:
243,023 bases
Orientation:
Minus strand

Genomic View for PPP2R2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2C Gene

Regulatory Elements for PPP2R2C Gene

Proteins for PPP2R2C Gene

  • Protein details for PPP2R2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2T4-2ABG_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
    Protein Accession:
    Q9Y2T4
    Secondary Accessions:
    • A8MSY7
    • B7Z3Y1
    • Q7Z4V7
    • Q8NEC4
    • Q9H3G7

    Protein attributes for PPP2R2C Gene

    Size:
    447 amino acids
    Molecular mass:
    51515 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules

    Alternative splice isoforms for PPP2R2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R2C Gene

Proteomics data for PPP2R2C Gene at MOPED

Post-translational modifications for PPP2R2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP2R2C Gene

Domains for PPP2R2C Gene

Gene Families for PPP2R2C Gene

HGNC:
  • WDR :WD repeat domain containing
  • PPP2R :Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

UniProtKB/Swiss-Prot:

2ABG_HUMAN
Family:
  • Belongs to the phosphatase 2A regulatory subunit B family.:
    • Q9Y2T4
Similarity:
  • Contains 7 WD repeats.:
    • Q9Y2T4
genes like me logo Genes that share domains with PPP2R2C: view

Function for PPP2R2C Gene

Molecular function for PPP2R2C Gene

GENATLAS Biochemistry: protein phosphatase 2A (formerly 2A),regulatory subunit B,gamma isoform
UniProtKB/Swiss-Prot Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Gene Ontology (GO) - Molecular Function for PPP2R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19156129
GO:0008601 protein phosphatase type 2A regulator activity NAS 10945473
genes like me logo Genes that share ontologies with PPP2R2C: view

Phenotypes for PPP2R2C Gene

GenomeRNAi human phenotypes for PPP2R2C:
genes like me logo Genes that share phenotypes with PPP2R2C: view

miRNA for PPP2R2C Gene

miRTarBase miRNAs that target PPP2R2C

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP2R2C Gene

Localization for PPP2R2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R2C Gene COMPARTMENTS Subcellular localization image for PPP2R2C gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPP2R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex NAS 10945473
genes like me logo Genes that share ontologies with PPP2R2C: view

Pathways for PPP2R2C Gene

genes like me logo Genes that share pathways with PPP2R2C: view

Gene Ontology (GO) - Biological Process for PPP2R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0034047 regulation of protein phosphatase type 2A activity NAS 10945473
GO:0050790 regulation of catalytic activity --
genes like me logo Genes that share ontologies with PPP2R2C: view

Compounds for PPP2R2C Gene

(5) Tocris Compounds for PPP2R2C Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]
genes like me logo Genes that share compounds with PPP2R2C: view

Transcripts for PPP2R2C Gene

Unigene Clusters for PPP2R2C Gene

Protein phosphatase 2, regulatory subunit B, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2C Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9:

Relevant External Links for PPP2R2C Gene

GeneLoc Exon Structure for
PPP2R2C
ECgene alternative splicing isoforms for
PPP2R2C

Expression for PPP2R2C Gene

mRNA expression in normal human tissues for PPP2R2C Gene

mRNA differential expression in normal tissues according to GTEx for PPP2R2C Gene

This gene is overexpressed in Brain - Cortex (4.9), Brain - Frontal Cortex (BA9) (4.8), Brain - Anterior cingulate cortex (BA24) (4.3), Brain - Nucleus accumbens (basal ganglia) (4.1), and Brain - Spinal cord (cervical c-1) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPP2R2C Gene

SOURCE GeneReport for Unigene cluster for PPP2R2C Gene Hs.479069

genes like me logo Genes that share expressions with PPP2R2C: view

Orthologs for PPP2R2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R2C 36
  • 99.85 (n)
  • 99.78 (a)
PPP2R2C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R2C 36
  • 91.55 (n)
  • 99.77 (a)
PPP2R2C 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R2C 36
  • 92.1 (n)
  • 99.3 (a)
PPP2R2C 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r2c 36
  • 90.92 (n)
  • 99.06 (a)
Ppp2r2c 16
Ppp2r2c 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R2C 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R2C 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r2c 36
  • 91.16 (n)
  • 99.3 (a)
chicken
(Gallus gallus)
Aves PPP2R2C 36
  • 80.58 (n)
  • 96.7 (a)
PPP2R2C 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R2C 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2c 36
  • 77.7 (n)
  • 91.89 (a)
zebrafish
(Danio rerio)
Actinopterygii BX470131.1 37
  • 76 (a)
OneToMany
ppp2r2c 37
  • 80 (a)
OneToMany
ppp2r2ca 36
  • 76.33 (n)
  • 84.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta tws 37
  • 64 (a)
OneToMany
tws 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea sur-6 37
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 37
  • 44 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13045 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 37
  • 64 (a)
OneToMany
Species with no ortholog for PPP2R2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R2C Gene

ENSEMBL:
Gene Tree for PPP2R2C (if available)
TreeFam:
Gene Tree for PPP2R2C (if available)

Paralogs for PPP2R2C Gene

Paralogs for PPP2R2C Gene

Selected SIMAP similar genes for PPP2R2C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP2R2C Gene

genes like me logo Genes that share paralogs with PPP2R2C: view

Variants for PPP2R2C Gene

Sequence variations from dbSNP and Humsavar for PPP2R2C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs744699 -- 6,429,046(+) CTGCA(A/C)CTCTG intron-variant
rs755403 -- 6,387,915(+) ATTCC(C/T)TACTT intron-variant
rs768636 -- 6,556,082(+) GTGAA(A/G)GATGC intron-variant, upstream-variant-2KB
rs872858 -- 6,389,318(+) CTCCC(C/T)TCGTC intron-variant
rs872881 -- 6,463,074(-) TTTGA(C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2C Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv469711 CNV Loss 16826518
nsv878522 CNV Loss 21882294
nsv878523 CNV Loss 21882294
esv2726998 CNV Deletion 23290073
esv2223041 CNV Deletion 18987734
nsv290117 CNV Loss 16902084
dgv856n67 CNV Loss 20364138
nsv10438 CNV Gain 18304495
esv2726999 CNV Deletion 23290073
esv1422471 CNV Deletion 17803354
esv2727000 CNV Deletion 23290073
nsv829847 CNV Gain 17160897
nsv878525 CNV Loss 21882294
esv268203 CNV Insertion 20981092
nsv4213 CNV Insertion 18451855
esv2674888 CNV Deletion 23128226
esv2727001 CNV Deletion 23290073
esv27681 CNV Gain 19812545
esv23635 CNV Loss 19812545
nsv527210 CNV Gain 19592680
nsv4214 CNV Insertion 18451855
nsv829849 CNV Loss 17160897
esv2727002 CNV Deletion 23290073
esv2727003 CNV Deletion 23290073
esv2674049 CNV Deletion 23128226
nsv291891 CNV Loss 16902084
nsv878526 CNV Loss 21882294
esv28719 CNV Loss 19812545

Relevant External Links for PPP2R2C Gene

HapMap Linkage Disequilibrium report
PPP2R2C
Human Gene Mutation Database (HGMD)
PPP2R2C

Disorders for PPP2R2C Gene

Relevant External Links for PPP2R2C

Genetic Association Database (GAD)
PPP2R2C
Human Genome Epidemiology (HuGE) Navigator
PPP2R2C
genes like me logo Genes that share disorders with PPP2R2C: view

No data available for UniProtKB/Swiss-Prot for PPP2R2C Gene

Publications for PPP2R2C Gene

  1. Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit. (PMID: 10574460) Torres R. … Polymeropoulos M.H. (DNA Res. 1999) 2 3 4
  2. Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16. (PMID: 10945473) Hu P. … Zhao S. (Genomics 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. (PMID: 19734900) Rung J. … Sladek R. (Nat. Genet. 2009) 3 49

Products for PPP2R2C Gene

Sources for PPP2R2C Gene

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