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Aliases for PPP2R2C Gene

Aliases for PPP2R2C Gene

  • Protein Phosphatase 2 Regulatory Subunit B, Gamma 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Gamma Isoform 2 3
  • PP2A Subunit B Isoform Gamma 2 4
  • IMYPNO1 3 4
  • Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Gamma Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Gamma Isoform 2
  • Gamma Isoform Of Regulatory Subunit B55, Protein Phosphatase 2 3
  • Phosphoprotein Phosphatase 2A BR Gamma Regulatory Chain 3
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma 2
  • Protein Phosphatase 2A1 B Gamma Subunit 3
  • PP2A, Subunit B, PR55-Gamma Isoform 3
  • PP2A, Subunit B, B55-Gamma Isoform 3
  • PP2A, Subunit B, R2-Gamma Isoform 3
  • PP2A Subunit B Isoform PR55-Gamma 4
  • PP2A, Subunit B, B-Gamma Isoform 3
  • PP2A Subunit B Isoform B55-Gamma 4
  • PP2A Subunit B Isoform R2-Gamma 4
  • B55-GAMMA 3
  • IMYPNO 3
  • PR55G 3
  • PR52 3

External Ids for PPP2R2C Gene

Previous GeneCards Identifiers for PPP2R2C Gene

  • GC04M006220
  • GC04M006419
  • GC04M006317
  • GC04M006386
  • GC04M006441

Summaries for PPP2R2C Gene

Entrez Gene Summary for PPP2R2C Gene

  • The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R2C Gene

PPP2R2C (Protein Phosphatase 2 Regulatory Subunit B, Gamma) is a Protein Coding gene. Among its related pathways are CTLA4 Signaling and p70S6K Signaling. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2B.

UniProtKB/Swiss-Prot for PPP2R2C Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Tocris Summary for PPP2R2C Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2C Gene

Genomics for PPP2R2C Gene

Regulatory Elements for PPP2R2C Gene

Enhancers for PPP2R2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP2R2C on UCSC Golden Path with GeneCards custom track

Promoters for PPP2R2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2R2C on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2R2C Gene

Chromosome:
4
Start:
6,320,578 bp from pter
End:
6,563,600 bp from pter
Size:
243,023 bases
Orientation:
Minus strand

Genomic View for PPP2R2C Gene

Genes around PPP2R2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2C Gene

Proteins for PPP2R2C Gene

  • Protein details for PPP2R2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2T4-2ABG_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
    Protein Accession:
    Q9Y2T4
    Secondary Accessions:
    • A8MSY7
    • B7Z3Y1
    • Q7Z4V7
    • Q8NEC4
    • Q9H3G7

    Protein attributes for PPP2R2C Gene

    Size:
    447 amino acids
    Molecular mass:
    51515 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

    Alternative splice isoforms for PPP2R2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R2C Gene

Proteomics data for PPP2R2C Gene at MOPED

Post-translational modifications for PPP2R2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP2R2C Gene

Domains & Families for PPP2R2C Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2T4

UniProtKB/Swiss-Prot:

2ABG_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PPP2R2C: view

Function for PPP2R2C Gene

Molecular function for PPP2R2C Gene

GENATLAS Biochemistry:
protein phosphatase 2A (formerly 2A),regulatory subunit B,gamma isoform
UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
genes like me logo Genes that share phenotypes with PPP2R2C: view

Animal Model Products

miRNA for PPP2R2C Gene

miRTarBase miRNAs that target PPP2R2C

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2C Gene

Localization for PPP2R2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R2C Gene COMPARTMENTS Subcellular localization image for PPP2R2C gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP2R2C Gene

Pathways & Interactions for PPP2R2C Gene

genes like me logo Genes that share pathways with PPP2R2C: view

Gene Ontology (GO) - Biological Process for PPP2R2C Gene

None

No data available for SIGNOR curated interactions for PPP2R2C Gene

Drugs & Compounds for PPP2R2C Gene

(3) Drugs for PPP2R2C Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPP2R2C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ceramide
3102-57-6
DL-AP3
20263-06-3

(5) Tocris Compounds for PPP2R2C Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
genes like me logo Genes that share compounds with PPP2R2C: view

Transcripts for PPP2R2C Gene

Unigene Clusters for PPP2R2C Gene

Protein phosphatase 2, regulatory subunit B, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2C Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9:

Relevant External Links for PPP2R2C Gene

GeneLoc Exon Structure for
PPP2R2C
ECgene alternative splicing isoforms for
PPP2R2C

Expression for PPP2R2C Gene

mRNA expression in normal human tissues for PPP2R2C Gene

mRNA differential expression in normal tissues according to GTEx for PPP2R2C Gene

This gene is overexpressed in Brain - Cortex (x4.9), Brain - Frontal Cortex (BA9) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.3), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for PPP2R2C Gene

This gene is overexpressed in Heart (42.5) and Frontal cortex (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPP2R2C Gene



SOURCE GeneReport for Unigene cluster for PPP2R2C Gene Hs.479069

genes like me logo Genes that share expression patterns with PPP2R2C: view

Protein tissue co-expression partners for PPP2R2C Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PPP2R2C Gene

Orthologs for PPP2R2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2R2C 35
  • 91.55 (n)
  • 99.77 (a)
PPP2R2C 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R2C 35
  • 92.1 (n)
  • 99.3 (a)
PPP2R2C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r2c 35
  • 90.92 (n)
  • 99.06 (a)
Ppp2r2c 16
Ppp2r2c 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R2C 35
  • 99.85 (n)
  • 99.78 (a)
PPP2R2C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r2c 35
  • 91.16 (n)
  • 99.3 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R2C 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R2C 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R2C 35
  • 80.58 (n)
  • 96.7 (a)
PPP2R2C 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R2C 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2c 35
  • 77.7 (n)
  • 91.89 (a)
zebrafish
(Danio rerio)
Actinopterygii ppp2r2ca 35
  • 76.33 (n)
  • 84.8 (a)
BX470131.1 36
  • 76 (a)
OneToMany
ppp2r2c 36
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tws 37
  • 76 (a)
tws 36
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sur-6 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 36
  • 44 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13045 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 36
  • 64 (a)
OneToMany
Species with no ortholog for PPP2R2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R2C Gene

ENSEMBL:
Gene Tree for PPP2R2C (if available)
TreeFam:
Gene Tree for PPP2R2C (if available)

Paralogs for PPP2R2C Gene

Paralogs for PPP2R2C Gene

(3) SIMAP similar genes for PPP2R2C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP2R2C Gene

genes like me logo Genes that share paralogs with PPP2R2C: view

Variants for PPP2R2C Gene

Sequence variations from dbSNP and Humsavar for PPP2R2C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs872858 -- 6,389,318(+) CTCCC(C/T)TCGTC intron-variant
rs872881 -- 6,463,074(-) TTTGA(C/T)GCAAA intron-variant
rs872882 -- 6,463,001(-) CCTCT(G/T)TCCCA intron-variant
rs872883 -- 6,462,820(-) TTTGG(A/C/G)TGAAG intron-variant
rs875579 -- 6,561,216(+) GACTC(A/G)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2C Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv469711 CNV Loss 16826518
nsv878522 CNV Loss 21882294
nsv878523 CNV Loss 21882294
esv2726998 CNV Deletion 23290073
esv2223041 CNV Deletion 18987734
nsv290117 CNV Loss 16902084
dgv856n67 CNV Loss 20364138
nsv10438 CNV Gain 18304495
esv2726999 CNV Deletion 23290073
esv1422471 CNV Deletion 17803354
esv2727000 CNV Deletion 23290073
nsv829847 CNV Gain 17160897
nsv878525 CNV Loss 21882294
esv268203 CNV Insertion 20981092
nsv4213 CNV Insertion 18451855
esv2674888 CNV Deletion 23128226
esv2727001 CNV Deletion 23290073
esv27681 CNV Gain 19812545
esv23635 CNV Loss 19812545
nsv527210 CNV Gain 19592680
nsv4214 CNV Insertion 18451855
nsv829849 CNV Loss 17160897
esv2727002 CNV Deletion 23290073
esv2727003 CNV Deletion 23290073
esv2674049 CNV Deletion 23128226
nsv291891 CNV Loss 16902084
nsv878526 CNV Loss 21882294
esv28719 CNV Loss 19812545

Variation tolerance for PPP2R2C Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R2C Gene

Human Gene Mutation Database (HGMD)
PPP2R2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2C Gene

Disorders for PPP2R2C Gene

Relevant External Links for PPP2R2C

Genetic Association Database (GAD)
PPP2R2C
Human Genome Epidemiology (HuGE) Navigator
PPP2R2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R2C

No disorders were found for PPP2R2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2C Gene

Publications for PPP2R2C Gene

  1. Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16. (PMID: 10945473) Hu P. … Zhao S. (Genomics 2000) 2 3 4 67
  2. Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit. (PMID: 10574460) Torres R. … Polymeropoulos M.H. (DNA Res. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1. (PMID: 24841198) Lee C.W. … Lee S.C. (J. Biol. Chem. 2014) 3
  5. Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes. (PMID: 23287597) Comandini A. … Franzese O. (Mol. Immunol. 2013) 3

Products for PPP2R2C Gene

Sources for PPP2R2C Gene

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