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PPP2R2C Gene

protein-coding   GIFtS: 60
GCID: GC04M006322

Protein Phosphatase 2, Regulatory Subunit B, Gamma

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
  Search for PPP2R2C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit B, Gamma1 2     Phosphoprotein Phosphatase 2A BR Gamma Regulatory Chain2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Gamma
Isoform1 2
     PP2A, Subunit B, B-Gamma Isoform2
PP2A Subunit B Isoform Gamma1 3     PP2A, Subunit B, B55-Gamma Isoform2
IMYPNO12 3     PP2A, Subunit B, PR55-Gamma Isoform2
PR522 5     PP2A, Subunit B, R2-Gamma Isoform2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Gamma Isoform1     Protein Phosphatase 2A1 B Gamma Subunit2
B55-GAMMA2     Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Gamma
Isoform2
IMYPNO2     PP2A Subunit B Isoform B55-Gamma3
PR55G2     PP2A Subunit B Isoform PR55-Gamma3
Gamma Isoform Of Regulatory Subunit B55, Protein Phosphatase 22     PP2A Subunit B Isoform R2-Gamma3

External Ids:    HGNC: 93061   Entrez Gene: 55222   Ensembl: ENSG000000742117   OMIM: 6059975   UniProtKB: Q9Y2T43   

Export aliases for PPP2R2C gene to outside databases

Previous GC identifers: GC04M006220 GC04M006419 GC04M006317 GC04M006386 GC04M006441


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R2C Gene:
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of
the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It
consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory
subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate
selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq,
Jul 2008)

GeneCards Summary for PPP2R2C Gene:
PPP2R2C (protein phosphatase 2, regulatory subunit B, gamma) is a protein-coding gene. GO annotations related to this gene include protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2D.

UniProtKB/Swiss-Prot: 2ABG_HUMAN, Q9Y2T4
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment

summary for PPP2R2C Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R2C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R2C gene promoter:
         AhR   RP58   Elk-1   AML1a   Ik-3   Arnt   GATA-1   CREB   Ik-2   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP2R2C promoter sequence
   Search Chromatin IP Primers for PPP2R2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

PPP2R2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R2C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M006322:  view genomic region     (about GC identifiers)

Start:
6,322,305 bp from pter      End:
6,565,327 bp from pter
Size:
243,023 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 2ABG_HUMAN, Q9Y2T4 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform  
Size: 447 amino acids; 51515 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules
Caution: The EMBL entry for PubMed:10574460 is not complete, the paper shows the rest of the sequence (residues 1
to 23)
Secondary accessions: A8MSY7 B7Z3Y1 Q7Z4V7 Q8NEC4 Q9H3G7
Alternative splicing: 4 isoforms:  Q9Y2T4-1   Q9Y2T4-2   Q9Y2T4-3   Q9Y2T4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R2C: NX_Q9Y2T4

Explore proteomics data for PPP2R2C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP2R2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193923.1  NP_001193924.1  NP_001193925.1  NP_870991.1  

    ENSEMBL proteins: 
     ENSP00000335083   ENSP00000423649   ENSP00000422374   ENSP00000372042   ENSP00000425247  
     ENSP00000423650  

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    Cloud-Clone Corp. Proteins for PPP2R2C

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR000009 PP2A_PR55
     IPR018067 PP2A_PR55_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2T4

    ProtoNet protein and cluster: Q9Y2T4

    1 Blocks protein domain: IPB000009 Protein phosphatase 2A regulatory subunit PR55

    UniProtKB/Swiss-Prot: 2ABG_HUMAN, Q9Y2T4
    Similarity: Belongs to the phosphatase 2A regulatory subunit B family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with PPP2R2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2ABG_HUMAN, Q9Y2T4
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment

         Genatlas biochemistry entry for PPP2R2C:
    protein phosphatase 2A (formerly 2A),regulatory subunit B,gamma isoform

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19156129
    GO:0008601protein phosphatase type 2A regulator activity NAS10945473
         
    Find genes that share ontologies with PPP2R2C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP2R2C:
     Increased Akt phosphorylation  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R2C
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    miRTarBase miRNAs that target PPP2R2C:
    hsa-mir-142-3p (MIRT021554)

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    Selected qRT-PCR Assays for microRNAs that regulate PPP2R2C (see all 50):
    hsa-miR-411* hsa-miR-379* hsa-miR-300 hsa-miR-429 hsa-miR-4272 hsa-miR-624 hsa-miR-219-5p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R2C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R2C

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex NAS10945473

    Find genes that share ontologies with PPP2R2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R2C About   (see all 33)  
    See pathways by source

    SuperPathContained pathways About
    1p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    CDK5 Pathway0.36
    Erythropoietin Pathway0.37
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    4ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    5Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cell Cycle Control by BTG Proteins0.36


    Find genes that share SuperPaths with PPP2R2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R2C (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    4 GeneGo (Thomson Reuters) Pathways for PPP2R2C
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    3 BioSystems Pathways for PPP2R2C
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway


    Selected Kegg Pathways  (Kegg details for PPP2R2C) (see all 8):
        mRNA surveillance pathway
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Hippo signaling pathway
    Tight junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R2C
    Interactions:

        Search GeneGlobe Interaction Network for PPP2R2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R2C (Q9Y2T41, 3 ENSP000003350834) via UniProtKB, MINT, STRING, and/or I2D (see all 186)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677751, 3, ENSP000004184474EBI-1774058,EBI-712311 I2D: score=2 STRING: ENSP00000418447
    BAG2O958163, ENSP000003597274I2D: score=2 STRING: ENSP00000359727
    CCT4P509913, ENSP000003779584I2D: score=2 STRING: ENSP00000377958
    PPP2R1BP301543, ENSP000003113444I2D: score=2 STRING: ENSP00000311344
    TCP1P179873, ENSP000003173344I2D: score=2 STRING: ENSP00000317334
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0050790regulation of catalytic activity NAS10945473

    Find genes that share ontologies with PPP2R2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP2R2C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP2R2C gene (5 alternative transcripts): 
    NM_001206994.1  NM_001206995.1  NM_001206996.1  NM_181876.2  NM_020416.3  

    Unigene Cluster for PPP2R2C:

    Protein phosphatase 2, regulatory subunit B, gamma
    Hs.479069  [show with all ESTs]
    Unigene Representative Sequence: NM_001206996
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335585(uc003gja.3 uc003gjb.3 uc003gjc.3 uc011bwd.2 uc011bwe.2)
    ENST00000506140 ENST00000515571 ENST00000382599 ENST00000507294 ENST00000513943(uc003gjd.1)
    ENST00000314348 ENST00000509917 ENST00000507028
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    hsa-miR-411* hsa-miR-379* hsa-miR-300 hsa-miR-429 hsa-miR-4272 hsa-miR-624 hsa-miR-219-5p hsa-miR-374a
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R2C
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R2C

    Additional mRNA sequence: 

    AF086924.1 AF145027.1 AK093115.1 AK122849.1 AK127386.1 AK296474.1 AK316003.1 BC021735.2 
    BC032954.2 BC045682.1 

    13 DOTS entries:

    DT.448415  DT.406918  DT.91711726  DT.91761739  DT.91863225  DT.448416  DT.121270213  DT.100750113 
    DT.101984071  DT.121631299  DT.121270270  DT.40250434  DT.91761727 

    Selected AceView cDNA sequences (see all 226):

    AA733098 BE703790 AI220464 AI351312 AI769949 BE703775 AA987907 AI078291 
    AK093115 BE703559 BM689787 F04816 BE703791 BE703785 AI857659 AW043652 
    AI272056 CK002310 H45375 CF454884 BE703867 AI869291 AA151244 AI523680 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2C (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                            -     -           -                                   -                                             
    SP2:              -     -     -     -     -     -     -           -                                   -                                             
    SP3:                                                              -                                   -                                             
    SP4:                                                              -                                   -                                             
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PPP2R2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTCAAGT
    PPP2R2C Expression
    About this image


    PPP2R2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             Ventral/hypothalamic-like neurons
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Lung (Respiratory System)
             Basal Cells Trachea
    PPP2R2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479069
        Custom PCR Arrays for PPP2R2C
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R2C gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r2c1 , 5 protein phosphatase 2 (formerly 2A), regulatory subunit more5
    protein phosphatase 2, regulatory subunit B, gamma1
    90.92(n)1
    99.06(a)1
      5 (19.28 cM)5
    2696431  NM_172994.21  NP_766582.11 
     368685135 
    chicken
    (Gallus gallus)
    Aves PPP2R2C1 protein phosphatase 2, regulatory subunit B, gamma 80.58(n)
    96.7(a)
      422858  XM_420804.3  XP_420804.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R2C6
    protein phosphatase 2, regulatory subunit B, gamma...
    90(a)
    1 ↔ 1
    5(80348599-80408585)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppp2r2c1 protein phosphatase 2, regulatory subunit B, gamma 77.7(n)
    91.89(a)
      100490097  XM_002938267.2  XP_002938313.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp2r2ca1 protein phosphatase 2, regulatory subunit B, gamma more 76.33(n)
    84.8(a)
      100002802  NM_001037394.1  NP_001032471.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tws3 imaginal disc pattern formation protein
    phosphatase more
    76(a)   85F13   --
    worm
    (Caenorhabditis elegans)
    Secernentea sur-66
    Protein SUR-6 (sur-6) mRNA, complete cds
    56(a)
    1 → many
    I(9754122-9757898) WBGene00006352
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC556
    Non-essential regulatory subunit B of protein phos...
    44(a)
    1 → many
    VII(145809-147389) YGL190C
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.130452 Vitis vinifera transcribed sequence with weak similarity more 98.11(n)    CF609659.1 


    ENSEMBL Gene Tree for PPP2R2C (if available)
    TreeFam Gene Tree for PPP2R2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R2C gene
    PPP2R2D2  PPP2R2B2  PPP2R2A2  
    3 SIMAP similar genes for PPP2R2C using alignment to 3 protein entries:     2ABG_HUMAN (see all proteins):
    PPP2R2D    PPP2R2A    PPP2R2B

    Find genes that share paralogs with PPP2R2C           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PPP2R2C
    PGOHUM00000245922


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R2C (see all 6298)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850677371,2
    --6321841(+) GTGGGA/GGAGCA 4 -- ds50010--------
    rs767937391,2
    C,F--6321882(+) ATTGCG/AAGCTA 4 -- ds50011Minor allele frequency- A:0.01WA 118
    rs743637731,2
    C,F--6321916(+) TTTCCT/CCATCT 4 -- ds50013Minor allele frequency- C:0.08WA CSA 122
    rs43791231,2
    H--6321920(+) ctcatC/GtgtaT 4 -- ds50014Minor allele frequency- G:0.00NS EA 410
    rs1902252171,2
    --6322005(+) GACAAC/TTATCA 4 -- ds50010--------
    rs100183501,2
    C,F,H--6322101(+) aggtcG/Atctta 4 -- ds500111Minor allele frequency- A:0.13NS NA WA CSA EA 480
    rs1382857991,2
    --6322111(+) ATTAGC/TTCCAT 4 -- ds50010--------
    rs1824836121,2
    --6322113(+) TAGCTA/CCATTT 4 -- ds50010--------
    rs99966401,2
    C,F--6322184(+) AAACCC/TTTGAC 4 -- ds500110Minor allele frequency- T:0.14NA WA CSA EA 372
    rs100184371,2
    C,F--6322190(+) ttgacG/Atgaac 4 -- ds50019Minor allele frequency- A:0.14NA WA CSA EA 370

    HapMap Linkage Disequilibrium report for PPP2R2C (6322305 - 6565327 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPP2R2C (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727000CNV Deletion23290073
    esv2727002CNV Deletion23290073
    esv2674888CNV Deletion23128226
    esv2726999CNV Deletion23290073
    esv2674049CNV Deletion23128226
    esv2727001CNV Deletion23290073
    esv1422471CNV Deletion17803354
    esv2726998CNV Deletion23290073
    esv2727003CNV Deletion23290073
    esv2223041CNV Deletion18987734

    Human Gene Mutation Database (HGMD): PPP2R2C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R2C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605997    OMIM disorders: --


    Find genes that share disorders with PPP2R2C           About GenesLikeMe

    Genetic Association Database (GAD): PPP2R2C
    Human Genome Epidemiology (HuGE) Navigator: PPP2R2C (3 documents)

    Export disorders for PPP2R2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R2C gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with PPP2R2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16. (PubMed id 10945473)1, 2, 3 Hu P.... Zhao S. (Genomics 2000)
    2. Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit. (PubMed id 10574460)1, 2, 3 Torres R.... Polymeropoulos M.H. (DNA Res. 1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. (PubMed id 19734900)1, 4 Rung J....Sladek R. (Nat. Genet. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway. (PubMed id 24126060)1 Fan Y.L....Wan J.Q. (FEBS Lett. 2013)
    7. A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. (PubMed id 24189493)1 Chen H.W....Tan B.C. (Biochim. Biophys. Acta 2013)
    8. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (J. Gen. Virol. 2012)
    9. PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD. (PubMed id 22664926)1 Jacob C....Reif A. (Atten Defic Hyperact Disord 2012)
    10. Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. (PubMed id 20308991)1 Kim S. and Webster M.J. (Mol. Psychiatry 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5522 HGNC: 9306 AceView: PPP2R2C Ensembl:ENSG00000074211 euGenes: HUgn5522
    ECgene: PPP2R2C Kegg: 5522 H-InvDB: PPP2R2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R2C gene:
    Search GeneIP for patents involving PPP2R2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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