Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PPP2R2B Gene

protein-coding   GIFtS: 67
GCID: GC05M145969

Protein Phosphatase 2, Regulatory Subunit B, Beta

(Previous names: spinocerebellar ataxia 12, protein phosphatase 2 (formerly...)
(Previous symbol: SCA12)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Phosphatase 2, Regulatory Subunit B, Beta1 2     PP2APR55B2
SCA121 2     PP2APR55BETA2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Beta
Isoform1 2
     PR2AB55BETA2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Beta Isoform1 2     PR2ABBETA2
PP2A Subunit B Isoform Beta1 3     PR2APR55BETA2
PP2A Subunit B Isoform B55-Beta2 3     PR52B2
PP2A Subunit B Isoform PR55-Beta2 3     PR55-BETA2
PP2A Subunit B Isoform R2-Beta2 3     PR55BETA2
Spinocerebellar Ataxia 121     PP2A, Subunit B, B-Beta Isoform2
B55BETA2     Serine/Threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Beta
Isoform2
PP2AB55BETA2     Serine/Threonine Protein Phosphatase 2A, Neuronal Isoform2
PP2ABBETA2     Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Beta
Isoform2

External Ids:    HGNC: 93051   Entrez Gene: 55212   Ensembl: ENSG000001564757   OMIM: 6043255   UniProtKB: Q000053   
ORGUL members:         

Export aliases for PPP2R2B gene to outside databases

Previous GC identifers: GC05M145936 GC05M146549 GC05M145997 GC05M145949 GC05M141115


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PPP2R2B Gene:
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of
the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It
consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory
subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate
selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily.
Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration
of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of
speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been
identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28
copies) that can be expanded to 66-78 copies in cases of SCA12. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2R2B Gene:
PPP2R2B (protein phosphatase 2, regulatory subunit B, beta) is a protein-coding gene. Diseases associated with PPP2R2B include spinocerebellar ataxia type 12, and spinocerebellar ataxia type12. GO annotations related to this gene include protein complex binding and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2D.

UniProtKB/Swiss-Prot: 2ABB_HUMAN, Q00005
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A
holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates
neuronal survival through the mitochondrial fission and fusion balance (By similarity)

summary for PPP2R2B Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R2B gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP2R2B promoter sequence
   Search Chromatin IP Primers for PPP2R2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

PPP2R2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R2B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M145969:  view genomic region     (about GC identifiers)

Start:
145,967,936 bp from pter      End:
146,464,347 bp from pter
Size:
496,412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: 2ABB_HUMAN, Q00005 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform  
Size: 443 amino acids; 51710 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules
Sequence caution: Sequence=AAH31790.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG51642.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG51642.1;
Type=Erroneous termination; Positions=116; Note=Translated as Lys;
Secondary accessions: A6NEJ2 A8K102 B3KPD0 B7Z2F2 B7Z304 D3DQF7 D3DQF8 G3V149
Alternative splicing: 7 isoforms:  Q00005-1   Q00005-2   Q00005-3   Q00005-4   Q00005-5   Q00005-6   Q00005-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R2B: NX_Q00005

Explore proteomics data for PPP2R2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP2R2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001258828.1  NP_001258829.1  NP_001258877.1  NP_858060.2  NP_858061.2  NP_858062.1  NP_858063.1  NP_858064.1  

    ENSEMBL proteins: 
     ENSP00000377935   ENSP00000431320   ENSP00000377936   ENSP00000377933   ENSP00000336591  
     ENSP00000421396   ENSP00000426599   ENSP00000425828   ENSP00000429184   ENSP00000433890  
     ENSP00000421577   ENSP00000424409   ENSP00000434497   ENSP00000421224   ENSP00000425413  
     ENSP00000377931   ENSP00000349283   ENSP00000398779   ENSP00000377932  

    PPP2R2B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PPP2R2B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PPP2R2B
    GenScript Custom Purified and Recombinant Proteins Services for PPP2R2B
    Novus Biologicals PPP2R2B Proteins
    Novus Biologicals PPP2R2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PPP2R2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2R2B
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PPP2R2B
    OriGene Custom Antibody Services for PPP2R2B
    Novus Biologicals PPP2R2B Antibodies
    Abcam antibodies for PPP2R2B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPP2R2B
    LSBio Antibodies in human, mouse, rat for PPP2R2B

    PPP2R2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPP2R2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPP2R2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR000009 PP2A_PR55
     IPR019775 WD40_repeat_CS
     IPR018067 PP2A_PR55_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q00005

    ProtoNet protein and cluster: Q00005

    1 Blocks protein domain: IPB000009 Protein phosphatase 2A regulatory subunit PR55

    UniProtKB/Swiss-Prot: 2ABB_HUMAN, Q00005
    Domain: The N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal with
    critical basic and hydrophobic residues, that is necessary and sufficient for targeting the PP2A holoenzyme to
    the outer mitochondrial membrane (OMM) and does not affect holoenzyme formation or catalytic activity (By
    similarity)
    Domain: The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that confers resistance
    to the unfolding step process required for import and therefore prevents PPP2R2B matrix translocation and signal
    sequence cleavage (By similarity)
    Similarity: Belongs to the phosphatase 2A regulatory subunit B family
    Similarity: Contains 7 WD repeats


    PPP2R2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2ABB_HUMAN, Q00005
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A
    holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates
    neuronal survival through the mitochondrial fission and fusion balance (By similarity)

         Genatlas biochemistry entry for PPP2R2B:
    protein phosphatase 2A,regulating subunit 3,beta isoform specifically expressed in brain (PR53) with a polymorphic
    CAG repeat in the 5'utr promoter region

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19156129
    GO:0008601protein phosphatase type 2A regulator activity IEA--
    GO:0032403protein complex binding ----
         
    PPP2R2B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP2R2B:
     Increased apoptosis 

         1 MGI phenotypic allele for Ppp2r2b (no phenotypes)

    PPP2R2B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP2R2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP2R2B:
    hsa-mir-30e-3p (MIRT044115)

    Block miRNA regulation of human, mouse, rat PPP2R2B using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PPP2R2B:
    hsa-miR-548am hsa-miR-494 hsa-miR-548x hsa-miR-3923
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP2R2B
    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP2R2B

    Clone
    Products:
         
    OriGene clones in human, mouse for PPP2R2B (see all 42)
    OriGene ORF clones in mouse, rat for PPP2R2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): PPP2R2B (NM_181674)
    Sino Biological Human cDNA Clone for PPP2R2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R2B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPP2R2B
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPP2R2B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    2ABB_HUMAN, Q00005: Isoform 1: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Membrane (By
    similarity)
    2ABB_HUMAN, Q00005: Isoform 2: Cytoplasm (By similarity). Mitochondrion (By similarity). Mitochondrion outer
    membrane (By similarity). Note=Under basal conditions, localizes to both cytosolic and mitochondrial
    compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to
    the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is
    required to promote proapoptotic activity (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol3
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex IEA--
    GO:0005739mitochondrion ISS--
    GO:0005741mitochondrial outer membrane ISS--
    GO:0005829cytosol ----
    GO:0005856cytoskeleton IEA--

    PPP2R2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PPP2R2B About   (see all 33)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    CDK5 Pathway0.36
    Erythropoietin Pathway0.37
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    4ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    5Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cell Cycle Control by BTG Proteins0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R2B (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    4 GeneGo (Thomson Reuters) Pathways for PPP2R2B
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    3 BioSystems Pathways for PPP2R2B
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway



    Selected Kegg Pathways  (Kegg details for PPP2R2B) (see all 8):
        mRNA surveillance pathway
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Hippo signaling pathway
    Tight junction


    PPP2R2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2R2B: 
              mTOR Signaling in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PPP2R2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R2B (Q000051, 3 ENSP000003365914) via UniProtKB, MINT, STRING, and/or I2D (see all 413)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion ----
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0007286spermatid development ----
    GO:0007420brain development ----

    PPP2R2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP2R2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PPP2R2B gene (8 alternative transcripts): 
    NM_001271899.1  NM_001271900.1  NM_001271948.1  NM_181674.2  NM_181675.3  NM_181676.2  NM_181677.2  NM_181678.2  

    Unigene Cluster for PPP2R2B:

    Protein phosphatase 2, regulatory subunit B, beta
    Hs.655213  [show with all ESTs]
    Unigene Representative Sequence: M64930
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000394413(uc010jgm.3 uc003loe.3) ENST00000530902(uc003lof.4)
    ENST00000508545 ENST00000394414 ENST00000394411(uc003log.4) ENST00000336640
    ENST00000504198(uc011dbv.2 uc011dbu.2) ENST00000512639 ENST00000512984
    ENST00000522831 ENST00000528601 ENST00000515880 ENST00000512011 ENST00000532154
    ENST00000502876 ENST00000508267 ENST00000504565 ENST00000509721
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPP2R2B using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PPP2R2B:
    hsa-miR-548am hsa-miR-494 hsa-miR-548x hsa-miR-3923
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R2B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPP2R2B
    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R2B
    Clone
    Products:
         
    OriGene clones in human, mouse for PPP2R2B (see all 42)
    OriGene ORF clones in mouse, rat for PPP2R2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): PPP2R2B (NM_181674)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R2B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPP2R2B
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R2B
      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R2B
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R2B

    Additional mRNA sequence: 

    AK056192.1 AK289717.1 AK294659.1 AK295347.1 AK314810.1 BC031790.1 BX647887.1 M64930.1 
    NR_073526.1 NR_073527.1 

    22 DOTS entries:

    DT.95102002  DT.100747942  DT.313805  DT.91718449  DT.95102005  DT.100777757  DT.120873081  DT.91718452 
    DT.120873230  DT.91913760  DT.100648198  DT.100778238  DT.120873231  DT.100777761  DT.120872993  DT.120873064 
    DT.120873093  DT.120873187  DT.120873188  DT.120873239  DT.99983070  DT.40293703 

    Selected AceView cDNA sequences (see all 100):

    NM_181677 NM_181676 BM544542 CR607404 NM_004576 N48957 NM_181674 BC031790 
    BM663616 AV726282 F09344 BX464346 NM_181675 NM_181678 BI546495 BI544441 
    BM703527 M64930 AV727132 BM697553 BM805544 BX452633 BI824211 BI490027 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2B    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                    -     -                                                                     
    SP2:                          -                                                                     
    SP3:        -     -     -     -                                                                     
    SP4:                                                                                                
    SP5:        -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for PPP2R2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PPP2R2B expression in normal human tissues (normalized intensities)      PPP2R2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGCTCCT
    PPP2R2B Expression
    About this image


    PPP2R2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Cells Outer Nuclear Layer
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    PPP2R2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R2B Protein Expression

    Genevestigator expression for PPP2R2B

    SOURCE GeneReport for Unigene cluster: Hs.655213

    UniProtKB/Swiss-Prot: 2ABB_HUMAN, Q00005
    Tissue specificity: Brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2R2B: 
              mTOR Signaling in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPP2R2B
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R2B
    QuantiTect SYBR Green Assays in human, mouse, rat PPP2R2B
    QuantiFast Probe-based Assays in human, mouse, rat PPP2R2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PPP2R2B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r2b1 , 5 protein phosphatase 2 (formerly 2A), regulatory subunit more5
    protein phosphatase 2, regulatory subunit B, beta1
    94.15(n)1
    100(a)1
      18 (22.75 cM)5
    729301  NM_028392.31  NP_082668.11 
     426374325 
    chicken
    (Gallus gallus)
    Aves PPP2R2B1 protein phosphatase 2, regulatory subunit B, beta 83.59(n)
    96.66(a)
      416350  XM_004945052.1  XP_004945109.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R2B6
    protein phosphatase 2, regulatory subunit B, beta
    95(a)
    1 ↔ 1
    GL343234.1(164459-345689)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppp2r2b-A-prov2 phosphatase 2 (formerly 2A), regulatory subunit B (PR more 83.42(n)    AB000406.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003350121 serine/threonine-protein phosphatase 2A 55 kDa regulatory more 77.15(n)
    89.6(a)
      100335012  XM_002664496.3  XP_002664542.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta tws3 imaginal disc pattern formation protein
    phosphatase more
    79(a)   85F13   --
    worm
    (Caenorhabditis elegans)
    Secernentea sur-66
    Protein SUR-6 (sur-6) mRNA, complete cds
    58(a)
    1 → many
    I(9754122-9757898) WBGene00006352
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC55(YGL190C)4 Non-essential regulatory subunit B of protein phosphatase more   --   7(147389-145809) 852685  NP_011325.1 


    ENSEMBL Gene Tree for PPP2R2B (if available)
    TreeFam Gene Tree for PPP2R2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PPP2R2B gene
    PPP2R2D2  PPP2R2C2  PPP2R2A2  
    3 SIMAP similar genes for PPP2R2B using alignment to 9 protein entries:     2ABB_HUMAN (see all proteins):
    PPP2R2A    PPP2R2C    PPP2R2D

    PPP2R2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PPP2R2B (see all 9794)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3224811,2
    F,H--141136294(-) ttgccA/Gccttg 10 -- int12Minor allele frequency- G:0.04NS NA 122
    rs786127661,2
    C--141170692(+) TTGTT-/TTTGGC
            
    TTTGG
    18 -- int1 cds10--------
    rs114138581,2
    C--141185463(+) AAAAA-/A/CCCTTT 10 -- int12NA CSA 4
    rs772310961,2
    C--141221073(+) TGATT-/CT/TC 
            
    TTTTA
    10 -- int10--------
    rs117433151,2
    H--141224584(+) AAAAaA/Tatata 10 -- int1 trp30--------
    rs1486982501,2
    C--141234675(+) GTGTA-/TGTGTG
            
    TGTGT
    10 -- int10--------
    rs58719901,2
    C--141265292(+) ACCTA-/TTTTTT 10 -- int1 trp31Minor allele frequency- T:0.00CSA 2
    rs58719911,2
    C--141272213(+) CAAAG-/AAAAAA 10 -- int1 trp32Minor allele frequency- A:0.25NA CSA 4
    rs350235901,2
    C--141335153(+) CACTG-/GTGTGTG 10 -- int10--------
    rs1995672031,2
    --141338954(+) CTTAA-/TGTGTGT 10 -- int10--------

    HapMap Linkage Disequilibrium report for PPP2R2B (145967936 - 146217936 bp, first 250kb of PPP2R2B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPP2R2B (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2053966CNV Deletion18987734
    esv2730881CNV Deletion23290073
    esv2422173CNV Deletion20811451
    esv2730883CNV Deletion23290073
    esv2670593CNV Deletion23128226
    esv2660911CNV Deletion23128226
    esv2664858CNV Deletion23128226
    esv2730882CNV Deletion23290073
    esv2675913CNV Deletion23128226
    esv2672689CNV Deletion23128226

    Human Gene Mutation Database (HGMD): PPP2R2B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R2B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604325   
    OMIM disorders: 604326  
    UniProtKB/Swiss-Prot: 2ABB_HUMAN, Q00005
  • Spinocerebellar ataxia 12 (SCA12) [MIM:604326]: Spinocerebellar ataxia is a clinically and genetically
    heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor
    coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement
    of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA). Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for PPP2R2B (see all 29):    About MalaCards
    spinocerebellar ataxia type 12    spinocerebellar ataxia type12    spinocerebellar ataxia    ataxia
    dentatorubral-pallidoluysian atrophy    multiple system atrophy    ductal carcinoma in situ    cerebellar ataxia
    trypanosomiasis    chagas disease    alcohol dependence    neuronitis
    dementia    cystic fibrosis    hepatitis    hepatitis c
    systemic lupus erythematosus    lupus erythematosus    hiv-1    hepatitis b

    3 diseases from the University of Copenhagen DISEASES database for PPP2R2B:
    Spinocerebellar ataxia     Cerebellar ataxia     dentatorubral-pallidoluysian atrophy

    PPP2R2B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for PPP2R2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sca12 99.3 34 12140678 (5), 15148151 (4), 19953482 (3), 19235102 (2) (see all 13)
    sca17 92.2 11 15148151 (4), 19235102 (1), 19953482 (1), 17420317 (1)
    spinocerebellar ataxias 91.2 3 16138911 (1), 19417544 (1), 19953482 (1)
    drpla 86 7 19235102 (2), 15148151 (1), 17420317 (1), 17961920 (1) (see all 5)
    ataxias hereditary 77.6 3 15148151 (1), 17420317 (1)
    neurodegenerative diseases 53.7 1 18940801 (1)

    GeneTests: PPP2R2B
    GeneReviews: PPP2R2B
    Genetic Association Database (GAD): PPP2R2B
    Human Genome Epidemiology (HuGE) Navigator: PPP2R2B (16 documents)

    Export disorders for PPP2R2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PPP2R2B gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with PPP2R2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12. (PubMed id 10581021)1, 2, 3 Holmes S.E.... Margolis R.L. (Nat. Genet. 1999)
    2. Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. (PubMed id 1849734)1, 2, 3 Mayer R.E.... Hemmings B.A. (Biochemistry 1991)
    3. PPP2R2B CAG repeat length in the Han Chinese in Taiwan: Association analyses in neurological and psychiatric disorders and potential functional implications. (PubMed id 18484086)1, 4, 9 Chen C.M....Lee-Chen G.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia. (PubMed id 19235102)1, 4, 9 Rajkiewicz M....Zaremba J. (Neurol. Neurochir. Pol. 2008)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Genome-wide association study of alcohol dependence. (PubMed id 19581569)1, 4 Treutlein J....Rietschel M. (Arch. Gen. Psychiatry 2009)
    8. The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study. (PubMed id 19259763)1, 4 Wardle M....Robertson N.P. (J. Neurol. 2009)
    9. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    10. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)1, 4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5521 HGNC: 9305 AceView: PPP2R2B Ensembl:ENSG00000156475 euGenes: HUgn5521
    ECgene: PPP2R2B Kegg: 5521 H-InvDB: PPP2R2B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PPP2R2B Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PPP2R2B[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PPP2R2B gene:
    Search GeneIP for patents involving PPP2R2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2R2B
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPP2R2B   OriGene RNAi products in human, mouse, rat for PPP2R2B  
     OriGene qPCR primer pairs and template standards for PPP2R2B   OriGene Protein Over-expression Lysate for PPP2R2B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PPP2R2B  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPP2R2B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PPP2R2B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPP2R2B   OriGene Custom Protein Services for PPP2R2B  

     
     
     Block miRNA regulation of human, mouse, rat PPP2R2B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPP2R2B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R2B Predesigned siRNA for gene silencing in human, mouse, rat PPP2R2B
     QuantiFast Probe-based Assays in human, mouse, rat PPP2R2B QuantiTect SYBR Green Assays in human, mouse, rat PPP2R2B
     PCR Arrays including human, mouse, rat PPP2R2B Search Chromatin IP Primers for PPP2R2B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R2B  Search GeneGlobe Interaction Network for PPP2R2B
     Regulatory tfbs in PPP2R2B promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPP2R2B GenScript cDNA clones with any tag delivered in your preferred vector for PPP2R2B
     GenScript Custom Assay Services for PPP2R2B GenScript Custom overexpressing Cell Line Services for PPP2R2B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PPP2R2B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PPP2R2B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPP2R2B antibodies
     PPP2R2B proteins
     PPP2R2B lysates
     Antibodies for PPP2R2B
     See all of Abcam's Antibodies, Kits and Proteins for PPP2R2B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PPP2R2B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R2B
     SwitchGear 3'UTR luciferase reporter plasmids for PPP2R2B
     SwitchGear Promoter luciferase reporter plasmids for PPP2R2B
     ThermoFisher Antibody for PPP2R2B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R2B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R2B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP2R2B
     LSBio Antibodies in human, mouse, rat for PPP2R2B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPP2R2B gene at Home site.
    Version: 3.12.130 7 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4