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PPP2R2A Gene

protein-coding   GIFtS: 64
GCID: GC08P026204

Protein Phosphatase 2, Regulatory Subunit B, Alpha

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit B, Alpha1 2     PR55A2
PP2A Subunit B Isoform Alpha1 3     Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR52), Alpha
Isoform2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha
Isoform1
     Serine/Threonine Protein Phosphatase 2A, 55 KDA Regulatory Subunit B,
Alpha Isoform2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Alpha Isoform1     Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Alpha
Isoform2
B55A2     PP2A Subunit B Isoform B55-Alpha3
B55ALPHA2     PP2A Subunit B Isoform PR55-Alpha3
PR52A2     PP2A Subunit B Isoform R2-Alpha3

External Ids:    HGNC: 93041   Entrez Gene: 55202   Ensembl: ENSG000002219147   OMIM: 6049415   UniProtKB: P631513   

Export aliases for PPP2R2A gene to outside databases

Previous GC identifers: GC08P025922 GC08P026502 GC08P026170 GC08P025099 GC08P024693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R2A Gene:
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of
the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It
consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory
subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate
selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily.
Alternatively spliced transcript variants have been described. (provided by RefSeq, Apr 2010)

GeneCards Summary for PPP2R2A Gene:
PPP2R2A (protein phosphatase 2, regulatory subunit B, alpha) is a protein-coding gene. Diseases associated with PPP2R2A include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2D.

UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
direct the localization of the catalytic enzyme to a particular subcellular compartment

summary for PPP2R2A Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R2A gene promoter:
         GATA-3   SREBP-1c   ATF-2   Egr-1   FOXD3   SREBP-1b   MZF-1   SREBP-1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP2R2A promoter sequence
   Search Chromatin IP Primers for PPP2R2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

PPP2R2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R2A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P026204:  view genomic region     (about GC identifiers)

Start:
26,149,007 bp from pter      End:
26,230,196 bp from pter
Size:
81,190 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform  
Size: 447 amino acids; 51692 Da
Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A
consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa
constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins
that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,
R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell
signaling molecules. Interacts with TP53
1 PDB 3D structure from and Proteopedia for PPP2R2A:
3DW8 (3D)    
Secondary accessions: B2RBU8 B4E1T7 P50409 Q00007
Alternative splicing: 2 isoforms:  P63151-1   P63151-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R2A: NX_P63151

Explore proteomics data for PPP2R2A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys62, Lys105
  • Modification sites at PhosphoSitePlus

  • See PPP2R2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171062.1  NP_002708.1  

    ENSEMBL proteins: 
     ENSP00000370113   ENSP00000428164   ENSP00000428542   ENSP00000430320   ENSP00000429279  
     ENSP00000428705   ENSP00000428800   ENSP00000325074   ENSP00000428165  
    Reactome Protein details: P63151

    PPP2R2A Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PPP2R2A Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR000009 PP2A_PR55
     IPR018067 PP2A_PR55_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P63151

    ProtoNet protein and cluster: P63151

    UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151
    Similarity: Belongs to the phosphatase 2A regulatory subunit B family
    Similarity: Contains 7 WD repeats


    PPP2R2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2ABA_HUMAN, P63151
    Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might
    direct the localization of the catalytic enzyme to a particular subcellular compartment

         Genatlas biochemistry entry for PPP2R2A:
    protein phosphatase 2 (formerly 2A),regulatory subunit B (PR52),alpha isoform

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity TAS--
    GO:0005515protein binding IPI15761952
    GO:0008601protein phosphatase type 2A regulator activity TAS1849734
         
    PPP2R2A for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for PPP2R2A:
     Decreased Tat-dependent transc  Decreased focal adhesion (FA)   Increased Erk phosphorylation   Increased S DNA content 
     Increased cell death in HCC-19  Increased gamma-H2AX phosphory  Increased mitotic exit time 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP2R2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP2R2A:
    hsa-mir-26b-5p (MIRT029553), hsa-mir-92a-3p (MIRT049716), hsa-let-7a-5p (MIRT052508), hsa-mir-1 (MIRT023787), hsa-mir-31-5p (MIRT000490), hsa-mir-222-3p (MIRT003191), hsa-mir-155-5p (MIRT020735), hsa-mir-30a-5p (MIRT028533), hsa-let-7b-5p (MIRT052126)

    Block miRNA regulation of human, mouse, rat PPP2R2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R2A (see all 97):
    hsa-miR-361-5p hsa-miR-3146 hsa-miR-199a-3p hsa-miR-106a hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R2A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R2A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PPP2R2A

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PPP2R2A (NM_002717)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R2A

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex IDA17245430
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    PPP2R2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R2A About   (see all 48)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    Cell Cycle Control by BTG Proteins0.36
    Cyclin D associated events in G10.31
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    Renin-Angiotensin Pathway0.60
    4Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    CDK5 Pathway0.36
    Erythropoietin Pathway0.37
    5Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R2A (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    3 Cell Signaling Technology (CST) Pathways for PPP2R2A
        Phosphatases
    MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    4 GeneGo (Thomson Reuters) Pathways for PPP2R2A
        Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PPP2R2A (see all 7)
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    TGF-beta Receptor Signaling Pathway
    IL-6 Signaling Pathway
    TGF-beta receptor signaling

    4 Reactome Pathways for PPP2R2A
        Initiation of Nuclear Envelope Reformation
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
    Cyclin A/B1 associated events during G2/M transition
    Cyclin D associated events in G1


    Selected Kegg Pathways  (Kegg details for PPP2R2A) (see all 8):
        mRNA surveillance pathway
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Hippo signaling pathway
    Tight junction


    PPP2R2A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP2R2A
    Interactions:

        Search GeneGlobe Interaction Network for PPP2R2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R2A (P631511, 2, 3 ENSP000003701134) via UniProtKB, MINT, STRING, and/or I2D (see all 310)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677752, 3, ENSP000004184474MINT-8288206 I2D: score=4 STRING: ENSP00000418447
    PPP2R1BP301541, 3, ENSP000003113444EBI-1048931,EBI-357094 I2D: score=4 STRING: ENSP00000311344
    TP53P046372, 3, ENSP000002693054MINT-4299164 I2D: score=1 STRING: ENSP00000269305
    PPP2R1AP301531, 2, 3, ENSP000003248044EBI-1048931,EBI-302388 MINT-4299261 MINT-8288206 I2D: score=5 STRING: ENSP00000324804
    DAPK1P533552, 3, ENSP000003507854MINT-8204105 MINT-8204054 I2D: score=1 STRING: ENSP00000350785
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006470protein dephosphorylation IDA1849734
    GO:0007084mitotic nuclear envelope reassembly TAS--

    PPP2R2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP2R2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    1 DrugBank Compound for PPP2R2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R2A gene (2 alternative transcripts): 
    NM_001177591.1  NM_002717.3  

    Unigene Cluster for PPP2R2A:

    Protein phosphatase 2, regulatory subunit B, alpha
    Hs.146339  [show with all ESTs]
    Unigene Representative Sequence: CR936829
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000380737(uc003xek.3 uc003xeu.3 uc011laf.2) ENST00000518254
    ENST00000520329 ENST00000524169 ENST00000518397 ENST00000522535 ENST00000522150
    ENST00000523473 ENST00000521095 ENST00000523925 ENST00000524099 ENST00000519636
    ENST00000315985 ENST00000522482 ENST00000521557 ENST00000519439 ENST00000521484
    ENST00000523964
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPP2R2A (see all 97):
    hsa-miR-361-5p hsa-miR-3146 hsa-miR-199a-3p hsa-miR-106a hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-374a
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    GenScript: all cDNA clones in your preferred vector (see all 2): PPP2R2A (NM_002717)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R2A
      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R2A
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R2A

    Additional mRNA sequence: 

    AK095153.1 AK123721.1 AK303981.1 AK314823.1 AL050206.1 AY189686.1 BC041071.1 CR936829.1 
    M64929.1 

    Selected DOTS entries (see all 26):

    DT.219041  DT.75116267  DT.441782  DT.100724149  DT.86859974  DT.219043  DT.100644265  DT.97789259 
    DT.120648760  DT.91755647  DT.91755648  DT.100774243  DT.100803367  DT.100803368  DT.91909912  DT.101987136 
    DT.120648707  DT.120648746  DT.100027522  DT.120648725  DT.120648755  DT.120648775  DT.86836063  DT.95277725 

    Selected AceView cDNA sequences (see all 332):

    BM271867 BM699294 AA630349 NM_002717 BM782821 BQ433102 AA374830 BM786642 
    AI358643 BM669512 AA279630 CD109398 BM541466 BM853600 BU187051 BX117882 
    CB140965 BM850934 BE778171 AI571427 BI838168 CK821833 CD251910 AU119283 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATGGGATT
    PPP2R2A Expression
    About this image


    PPP2R2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Septum   
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    PPP2R2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146339

    UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151
    Tissue specificity: Expressed in all tissues examined

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R2A gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r2a1 , 5 protein phosphatase 2 (formerly 2A), regulatory subunit more5
    protein phosphatase 2, regulatory subunit B, alpha1
    93.93(n)1
    100(a)1
      14 (34.60 cM)5
    719781  NM_028032.31  NP_082308.11 
     670140575 
    chicken
    (Gallus gallus)
    Aves PPP2R2A1 protein phosphatase 2, regulatory subunit B, alpha 89.14(n)
    99.33(a)
      419523  NM_001030886.1  NP_001026057.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R2A6
    protein phosphatase 2, regulatory subunit B, alpha...
    99(a)
    1 ↔ 1
    GL343445.1(608561-650890)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.7342 X.laevis mRNA PPA2 for 55 kDa regulatory subunit 81.22(n)    X80697.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd19g042 wufd19g04 78.1(n)   327263  BC056824.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tws3 imaginal disc pattern formation protein
    phosphatase more
    79(a)   85F13   --
    worm
    (Caenorhabditis elegans)
    Secernentea sur-66
    Protein SUR-6 (sur-6) mRNA, complete cds
    60(a)
    1 → many
    I(9754122-9757898) WBGene00006352
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC556
    Non-essential regulatory subunit B of protein phos...
    46(a)
    1 → many
    VII(145809-147389) YGL190C
    soybean
    (Glycine max)
    eudicotyledons Gma.72392 Transcribed sequence with moderate similarity to protein more 73.64(n)  
    rice
    (Oryza sativa)
    Liliopsida AF081923.12   -- 77.78(n)    AF081923.1 


    ENSEMBL Gene Tree for PPP2R2A (if available)
    TreeFam Gene Tree for PPP2R2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R2A gene
    PPP2R2D2  PPP2R2B2  PPP2R2C2  
    3 SIMAP similar genes for PPP2R2A using alignment to 6 protein entries:     2ABA_HUMAN (see all proteins):
    PPP2R2D    PPP2R2C    PPP2R2B

    PPP2R2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPP2R2A
    PGOHUM00000245427


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R2A (see all 1528)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1170913801,2
    C,F--26147021(+) GCATAC/TCCAGA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1506450731,2
    C--26147072(+) AGCACA/GCAGTG 1 -- us2k10--------
    rs117815231,2
    C,H--26147080(+) GTGCAC/GTGAAG 1 -- us2k11Minor allele frequency- G:0.17NA 6
    rs1856195661,2
    --26147093(+) TTGTAA/CCTGTT 1 -- us2k10--------
    rs1401084951,2
    C--26147164(+) GTAACA/GTGGGA 1 -- us2k10--------
    rs1900873411,2
    --26147178(+) ATTCAC/TGCAGA 1 -- us2k10--------
    rs1164536821,2
    C,F--26147343(+) CCAAAC/AGCCTT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1822829901,2
    --26147617(+) AACGGA/CAGCTA 1 -- us2k10--------
    rs624941711,2
    C,F--26147817(+) TGATCA/GCATAG 1 -- us2k12Minor allele frequency- G:0.05NA 122
    rs1850266661,2
    --26147866(+) CCTACA/TGCAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP2R2A (26149007 - 26230196 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP2R2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269537CNV Insertion20981092
    esv2495705CNV Insertion19546169
    esv273393CNV Insertion20981092
    nsv831273CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604941    OMIM disorders: --

    18 diseases for PPP2R2A:    
    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    breast disease
    trypanosomiasis    chagas disease    teratoma    cerebritis
    hiv-1    cystic fibrosis    hepatitis c    prostate cancer
    alzheimer's disease    hepatitis    neuroblastoma    prostatitis
    breast cancer    neuronitis


    PPP2R2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP2R2A
    Human Genome Epidemiology (HuGE) Navigator: PPP2R2A (3 documents)

    Export disorders for PPP2R2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R2A gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with PPP2R2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. (PubMed id 1849734)1, 2, 3 Mayer R.E.... Hemmings B.A. (Biochemistry 1991)
    2. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PubMed id 19890961)1, 4 Dupont W.D....Smith J.R. (Cancer 2010)
    3. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)1, 2 Li H.H.... Liu X. (EMBO J. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Upregulation of miR-136 in human non-small cell lung cancer cells promotes Erk1/2 activation by targeting PPP2R2A. (PubMed id 23959478)1 Shen S....Wang J. (Tumour Biol. 2014)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5520 HGNC: 9304 AceView: PPP2R2A Ensembl:ENSG00000221914 euGenes: HUgn5520
    ECgene: PPP2R2A Kegg: 5520 H-InvDB: PPP2R2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R2A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R2A gene:
    Search GeneIP for patents involving PPP2R2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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