Aliases for PPP2R2A Gene
Aliases for PPP2R2A Gene
- Protein Phosphatase 2 Regulatory Subunit Balpha 2 3 5
- PP2A Subunit B Isoform Alpha 2 4
- Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Alpha Isoform 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha Isoform 2
- Protein Phosphatase 2, Regulatory Subunit B, Alpha 3
- PP2A Subunit B Isoform PR55-Alpha 4
- PP2A Subunit B Isoform B55-Alpha 4
External Ids for PPP2R2A Gene
- HGNC: 9304
- Entrez Gene: 5520
- Ensembl: ENSG00000221914
- OMIM: 604941
- UniProtKB: P63151
Previous GeneCards Identifiers for PPP2R2A Gene
- GC08P025922
- GC08P026502
- GC08P026170
- GC08P025099
- GC08P024693
Summaries for PPP2R2A Gene
-
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R2A Gene
PPP2R2A (Protein Phosphatase 2 Regulatory Subunit Balpha) is a Protein Coding gene. Among its related pathways are CTLA4 Signaling and Glycogen Metabolism. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R2D.
UniProtKB/Swiss-Prot for PPP2R2A Gene
-
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
-
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2A Gene
Genomics for PPP2R2A Gene
Regulatory Elements for PPP2R2A Gene
Enhancers for PPP2R2A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G026264 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 13.9 | -25.3 | -25250 | 3.7 | PKNOX1 ARNT RAD21 ZNF121 GATA2 FOS CREM CEBPB ZNF592 MEF2D | PPP2R2A LOC100129404 |
| GH08G026329 | 1.4 | Ensembl ENCODE dbSUPER | 11.3 | +39.2 | 39193 | 3.1 | FOXA2 ARID4B FOS SP5 MIER2 KAT8 MIER3 SMARCA4 GLIS1 SP7 | SDAD1P1 PPP2R2A BNIP3L PNMA2 DPYSL2 GC08M026286 |
| GH08G026374 | 1.4 | FANTOM5 Ensembl ENCODE | 10.2 | +82.9 | 82892 | 0.8 | HDAC1 ATF1 CBX3 ZNF2 RAD21 CHAMP1 RFX5 ZNF335 ZNF121 ZSCAN5C | SDAD1P1 PPP2R2A BNIP3L GC08M026286 |
| GH08G026257 | 1.1 | Ensembl ENCODE dbSUPER | 12.2 | -32.8 | -32814 | 2.3 | GATA2 POLR2A JUN MNT FOS NR2F2 | PPP2R2A LOC100129404 |
| GH08G026203 | 1.2 | Ensembl ENCODE dbSUPER | 11 | -86.9 | -86882 | 1.4 | JUN USF2 ZNF398 EP300 BRCA1 ATF2 FOXA1 GATA3 ZNF366 GATA2 | PPP2R2A LOC105379336 RNA5SP258 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PPP2R2A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for PPP2R2A Gene
- Chromosome:
- 8
- Start:
- 26,291,491 bp from pter
- End:
- 26,372,680 bp from pter
- Size:
- 81,190 bases
- Orientation:
- Plus strand
Genomic View for PPP2R2A Gene
Genes around PPP2R2A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.2 by Ensembl
- 8p21.2 by Entrez Gene
- 8p21.2 by HGNC
PPP2R2A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP2R2A Gene
Proteins for PPP2R2A Gene
-
Protein details for PPP2R2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P63151-2ABA_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Protein Accession:
- P63151
- B2RBU8
- B4E1T7
- P50409
- Q00007
Protein attributes for PPP2R2A Gene
- Size:
- 447 amino acids
- Molecular mass:
- 51692 Da
- Quaternary structure:
-
- Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751).
Protein Expression for PPP2R2A Gene
Post-translational modifications for PPP2R2A Gene
Other Protein References for PPP2R2A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for PPP2R2A (PPP2R2A)
- Novus Biologicals Antibodies for PPP2R2A
- Invitrogen Antibodies for PPP2R2A
- antibodies-online Antibodies for PPP2R2A: See all 23
- GeneTex PPP2R2A antibody for PPP2R2A
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R2A
Protein Products
-
OriGene Purified Proteins for PPP2R2A
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2R2A
- Origene Custom Protein Services for PPP2R2A
- antibodies-online Proteins for PPP2R2A: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PPP2R2A
Assay Products
No data available for DME Specific Peptides for PPP2R2A Gene
Domains & Families for PPP2R2A Gene
Gene Families for PPP2R2A Gene
Protein Domains for PPP2R2A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP2R2A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P63151- Family:
-
- Belongs to the phosphatase 2A regulatory subunit B family.
Function for PPP2R2A Gene
Molecular function for PPP2R2A Gene
- GENATLAS Biochemistry:
- protein phosphatase 2 (formerly 2A),regulatory subunit B (PR52),alpha isoform
- UniProtKB/Swiss-Prot Function:
- The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004722 | protein serine/threonine phosphatase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 9847399 |
| GO:0019888 | protein phosphatase regulator activity | TAS | 1849734 |
| GO:0032403 | protein complex binding | IEA | -- |
| GO:0048156 | tau protein binding | IEA | -- |
Phenotypes for PPP2R2A Gene
- GenomeRNAi human phenotypes for PPP2R2A:
-
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death HMECs cells
- Increased Sindbis virus (SINV) infection
- Decreased Tat-dependent transcription
- Increased Erk phosphorylation after EGF stimulation
- Increased mitotic exit time
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2R2A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R2A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
- Search ViGene Biosciences for PPP2R2A
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R2A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R2A
- GenScript: Design CRISPR guide RNA sequences for PPP2R2A
miRNA for PPP2R2A Gene
- miRTarBase miRNAs that target PPP2R2A
-
- hsa-mir-31-5p (MIRT000490)
- hsa-mir-222-3p (MIRT003191)
- hsa-mir-155-5p (MIRT020735)
- hsa-mir-1-3p (MIRT023787)
- hsa-mir-30a-5p (MIRT028533)
- hsa-mir-26b-5p (MIRT029553)
- hsa-mir-92a-3p (MIRT049716)
- hsa-let-7b-5p (MIRT052126)
- hsa-let-7a-5p (MIRT052508)
- hsa-mir-548t-5p (MIRT224722)
- hsa-mir-548az-5p (MIRT224728)
- hsa-mir-409-3p (MIRT322407)
- hsa-mir-551b-5p (MIRT322409)
- hsa-mir-605-3p (MIRT322410)
- hsa-mir-3910 (MIRT322413)
- hsa-mir-4796-3p (MIRT322414)
- hsa-let-7c-5p (MIRT322426)
- hsa-let-7d-5p (MIRT322427)
- hsa-let-7e-5p (MIRT322428)
- hsa-let-7f-5p (MIRT322429)
- hsa-mir-98-5p (MIRT322430)
- hsa-let-7g-5p (MIRT322431)
- hsa-let-7i-5p (MIRT322432)
- hsa-mir-4458 (MIRT322433)
- hsa-mir-4500 (MIRT322434)
- hsa-mir-218-5p (MIRT439914)
- hsa-mir-187-5p (MIRT506061)
- hsa-mir-154-5p (MIRT506062)
- hsa-mir-548t-3p (MIRT506063)
- hsa-mir-548ap-3p (MIRT506064)
- hsa-mir-548aa (MIRT506065)
- hsa-mir-3605-5p (MIRT561713)
- hsa-mir-3679-5p (MIRT561714)
- hsa-mir-1185-5p (MIRT561715)
- hsa-mir-4719 (MIRT561716)
- hsa-mir-4801 (MIRT561717)
- hsa-mir-4731-3p (MIRT561718)
- hsa-mir-101-3p (MIRT561719)
- hsa-mir-144-3p (MIRT561721)
- hsa-mir-3202 (MIRT566297)
- hsa-mir-4533 (MIRT566298)
miRNA Products
- Search ViGene Biosciences for PPP2R2A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PPP2R2A
- Browse OriGene Inhibitory RNA Products For PPP2R2A
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
Clone Products
- Sino Biological Human cDNA Clone for PPP2R2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PPP2R2A
- VectorBuilder custom plasmid, inducible vectors for PPP2R2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R2A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PPP2R2A
-
ViGene Biosciences adenoviral particle packaged cDNA for PPP2R2A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R2A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2A Gene
Localization for PPP2R2A Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | IDA | 1849734 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R2A Gene
Pathways & Interactions for PPP2R2A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cyclins and Cell Cycle Regulation |
.31
|
|
| 2 | Beta-Adrenergic Signaling |
.36
|
|
| 3 | p70S6K Signaling |
.60
|
.54
|
| 4 | Cell Cycle, Mitotic |
.83
|
.60
|
| 5 | ERK Signaling |
.61
|
.49
|
Pathways by source for PPP2R2A Gene
2 Cell Signaling Technology pathways for PPP2R2A Gene
5 BioSystems pathways for PPP2R2A Gene
16 Reactome pathways for PPP2R2A Gene
10 KEGG pathways for PPP2R2A Gene
4 GeneGo (Thomson Reuters) pathways for PPP2R2A Gene
25 Qiagen pathways for PPP2R2A Gene
Interacting Proteins for PPP2R2A Gene
Selected Interacting proteins:
ENSP00000325074
P63151-2ABA_HUMAN
for PPP2R2A Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
| GO:0000278 | mitotic cell cycle | IBA | -- |
| GO:0006470 | protein dephosphorylation | IDA | 1849734 |
| GO:0007084 | mitotic nuclear envelope reassembly | TAS | -- |
No data available for SIGNOR curated interactions for PPP2R2A Gene
Drugs & Compounds for PPP2R2A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclosporine | Approved, Investigational, Vet_approved | Pharma | Antagonist | Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor | 922 | |
| 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid | Experimental | Pharma | Target | 0 | ||
| Calyculin A | Experimental | Pharma | Protein phosphatase inhibitor, Protein phosphatase 1 and 2A inhibitor | 0 | ||
| Okadaic acid | Experimental | Pharma | Protein phosphatase 1 inhibitor, Protein phosphatase 1 and 2A inhibitor | 0 | ||
| Tautomycetin | Pharma | Selective PP1 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| FK 506 |
|
104987-11-3 |
|
|
(5) Tocris Compounds for PPP2R2A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calyculin A | Protein phosphatase 1 and 2A inhibitor | 101932-71-2 |
| Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
| FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
| Okadaic acid | Protein phosphatase 1 and 2A inhibitor | 78111-17-8 |
| Tautomycetin | Selective PP1 inhibitor | 119757-73-2 |
Transcripts for PPP2R2A Gene
mRNA/cDNA for PPP2R2A Gene
- (9) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (332) Selected AceView cDNA sequences:
- (24) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPP2R2A Gene
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R2A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R2A
- GenScript: Design CRISPR guide RNA sequences for PPP2R2A
miRNA Products
- Search ViGene Biosciences for PPP2R2A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PPP2R2A
- Browse OriGene Inhibitory RNA Products For PPP2R2A
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
Clone Products
- Sino Biological Human cDNA Clone for PPP2R2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PPP2R2A
- VectorBuilder custom plasmid, inducible vectors for PPP2R2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R2A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for PPP2R2A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP2R2A Gene
NURSA nuclear receptor signaling pathways regulating expression of PPP2R2A Gene:
PPP2R2ASOURCE GeneReport for Unigene cluster for PPP2R2A Gene:
Hs.146339mRNA Expression by UniProt/SwissProt for PPP2R2A Gene:
P63151-2ABA_HUMAN
Tissue specificity:
Expressed in all tissues examined.
Evidence on tissue expression from TISSUES for PPP2R2A Gene
- Nervous system(4.8)
- Lung(4.5)
- Liver(4.3)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for PPP2R2A
-
OriGene qPCR primer pairs and template standards for PPP2R2A
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R2A Gene
Orthologs for PPP2R2A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP2R2A 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PPP2R2A 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2R2A 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PPP2R2A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PPP2R2A 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppp2r2a 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ppp2r2a 34 |
|
||
| chicken (Gallus gallus) |
Aves | PPP2R2A 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PPP2R2A 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp2r2a 34 |
|
||
| Str.6179 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.734 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp2r2ab 35 |
|
OneToMany | |
| PPP2R2A (2 of 2) 35 |
|
OneToMany | |||
| ppp2r2d 34 |
|
||||
| wufd19g04 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | tws 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sur-6 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC55 35 |
|
OneToMany | |
| soybean (Glycine max) |
eudicotyledons | Gma.7239 34 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3832 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.21357 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6047 35 |
|
OneToMany |
- Species where no ortholog for PPP2R2A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PPP2R2A Gene
(3) SIMAP similar genes for PPP2R2A Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for PPP2R2A Gene
Variants for PPP2R2A Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034981 | -- | 26,362,496(+) | TGAAA(C/T)TCCGT | intron-variant | |
| rs1000061152 | -- | 26,314,032(+) | TTAAA(A/C)ATTAC | intron-variant | |
| rs1000086513 | -- | 26,303,385(+) | GTGCC(A/G)CTCCT | intron-variant | |
| rs1000137222 | -- | 26,306,305(+) | ACACC(A/G)TCTCT | intron-variant | |
| rs1000156121 | -- | 26,294,449(+) | CTTCA(A/G)GGTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2495705 | CNV | insertion | 19546169 |
| esv3305259 | CNV | mobile element insertion | 20981092 |
| esv3309120 | CNV | mobile element insertion | 20981092 |
| esv3324782 | CNV | insertion | 20981092 |
| esv3572648 | CNV | loss | 25503493 |
| esv3616666 | OTHER | inversion | 21293372 |
| esv3616698 | CNV | loss | 21293372 |
| esv3616699 | CNV | loss | 21293372 |
| nsv1076075 | CNV | deletion | 25765185 |
| nsv473268 | CNV | novel sequence insertion | 20440878 |
| nsv831273 | CNV | loss | 17160897 |
| nsv951118 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.31;
6.84% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PPP2R2A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP2R2A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2A Gene
Disorders for PPP2R2A Gene
Relevant External Links for PPP2R2A
No disorders were found for PPP2R2A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2A Gene
Publications for PPP2R2A Gene
- Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. (PMID: 1849734) Mayer R.E. … Hemmings B.A. (Biochemistry 1991) 2 3 4 64
- HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y. … Sakurai H. (FEBS Lett. 2015) 3 4 64
- Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PMID: 19890961) Dupont W.D. … Smith J.R. (Cancer 2010) 3 46 64
- A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PMID: 17245430) Li H.H. … Liu X. (EMBO J. 2007) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for PPP2R2A Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PPP2R2A
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2R2A
- Origene Custom Protein Services for PPP2R2A
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PPP2R2A
- Browse OriGene Inhibitory RNA Products For PPP2R2A
- OriGene qPCR primer pairs and template standards for PPP2R2A
- OriGene qPCR primer pairs for PPP2R2A
- OriGene CRISPR knockouts for PPP2R2A
- OriGene ORF clones in human for PPP2R2A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPP2R2A
- GenScript: Next-day shipping cDNA ORF clone for PPP2R2A in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PPP2R2A
- GenScript Custom Assay Services for PPP2R2A
- GenScript Custom overexpressing Cell Line Services for PPP2R2A
- GenScript: Design CRISPR guide RNA sequences for PPP2R2A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PPP2R2A
- Cell Signaling Technology (CST) Antibodies for PPP2R2A (PPP2R2A)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for PPP2R2A
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for PPP2R2A
- Novus Biologicals proteins and lysates for PPP2R2A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for PPP2R2A
- antibodies-online Antibodies for PPP2R2A: See all 23
- Search antibodies-online for kits
- antibodies-online Proteins for PPP2R2A: See all 7
- Search antibodies-online for peptides
- GeneTex PPP2R2A antibody for PPP2R2A
- Search GeneTex for Proteins for PPP2R2A
- ViGene Biosciences adenoviral particle packaged cDNA for PPP2R2A gene
- ViGene Biosciences lentiviral particle packaged cDNA for PPP2R2A gene
- ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
- Search ViGene Biosciences for PPP2R2A
- Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R2A
- Search Santa Cruz Biotechnology (SCBT) for PPP2R2A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R2A
- Horizon Cell Lines for PPP2R2A
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2R2A
- VectorBuilder custom plasmid, inducible vectors for PPP2R2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R2A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PPP2R2A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer