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PPP2R2A Gene

protein-coding GIFtS: 64
GCID: GC08P026204

Protein Phosphatase 2, Regulatory Subunit B, Alpha

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Protein Phosphatase 2, Regulatory Subunit B, Alpha¹ ²		PR55A²
PP2A Subunit B Isoform Alpha¹ ³		Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR52), Alpha Isoform²
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha Isoform¹		Serine/Threonine Protein Phosphatase 2A, 55 KDA Regulatory Subunit B, Alpha Isoform²
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B, Alpha Isoform¹		Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Alpha Isoform²
B55A²		PP2A Subunit B Isoform B55-Alpha³
B55ALPHA²		PP2A Subunit B Isoform PR55-Alpha³
PR52A²		PP2A Subunit B Isoform R2-Alpha³

External Ids:	HGNC: 9304¹	Entrez Gene: 5520²	Ensembl: ENSG00000221914⁷	OMIM: 604941⁵	UniProtKB: P63151³

Export aliases for PPP2R2A gene to outside databases

Previous GC identifers: GC08P025922 GC08P026502 GC08P026170 GC08P025099 GC08P024693

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R2A Gene:

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of

the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It

consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory

subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate

selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily.

Alternatively spliced transcript variants have been described. (provided by RefSeq, Apr 2010)

GeneCards Summary for PPP2R2A Gene:

PPP2R2A (protein phosphatase 2, regulatory subunit B, alpha) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase type 2A regulator activity. An important paralog of this gene is PPP2R2D.

UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might

direct the localization of the catalytic enzyme to a particular subcellular compartment

summary for PPP2R2A Gene:

Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from

serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the

actions of kinases and phosphorylases and therefore play an integral role in many signal transduction

pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,

calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a

divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the

phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This

makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr

phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are

subtype-specific.

Gene Wiki entry for PPP2R2A Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000008.10 NT_167187.2 NC_018919.2

Regulatory elements:

Regulatory transcription factor binding sites in the PPP2R2A gene promoter:
GATA-3 SREBP-1c ATF-2 Egr-1 FOXD3 SREBP-1b MZF-1 SREBP-1a FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP2R2A promoter sequence

Search Chromatin IP Primers for PPP2R2A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.2

PPP2R2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R2A gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P026204: view genomic region (about GC identifiers)

Start:	26,149,007 bp from pter	End:	26,230,196 bp from pter
Size:	81,190 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Size: 447 amino acids; 51692 Da

Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A

consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa

constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins

that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,

R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell

signaling molecules. Interacts with TP53

1 PDB 3D structure from and Proteopedia for PPP2R2A:

3DW8 (3D)

Secondary accessions: B2RBU8 B4E1T7 P50409 Q00007

Alternative splicing: 2 isoforms: P63151-1 P63151-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R2A: NX_P63151

Explore proteomics data for PPP2R2A at MOPED

Post-translational modifications:

Ubiquitination² at Lys62, Lys105

Modification sites at PhosphoSitePlus

See PPP2R2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001171062.1 NP_002708.1

ENSEMBL proteins:

ENSP00000370113 ENSP00000428164 ENSP00000428542 ENSP00000430320 ENSP00000429279

ENSP00000428705 ENSP00000428800 ENSP00000325074 ENSP00000428165

Reactome Protein details: P63151

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

WDR: WD repeat domain containing

5 InterPro protein domains:

IPR000009 PP2A_PR55

IPR018067 PP2A_PR55_CS

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry P63151

ProtoNet protein and cluster: P63151

UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151

Similarity: Belongs to the phosphatase 2A regulatory subunit B family

Similarity: Contains 7 WD repeats

Find genes that share domains with PPP2R2A About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: 2ABA_HUMAN, P63151

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might

direct the localization of the catalytic enzyme to a particular subcellular compartment

Genatlas biochemistry entry for PPP2R2A:

protein phosphatase 2 (formerly 2A),regulatory subunit B (PR52),alpha isoform

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004722	protein serine/threonine phosphatase activity	TAS	--
GO:0005515	protein binding	IPI	15761952
GO:0008601	protein phosphatase type 2A regulator activity	TAS	1849734

Find genes that share ontologies with PPP2R2A About GenesLikeMe

Phenotypes:
7 GenomeRNAi human phenotypes for PPP2R2A:

Decreased Tat-dependent transc	Decreased focal adhesion (FA)	Increased Erk phosphorylation	Increased S DNA content
Increased cell death in HCC-19	Increased gamma-H2AX phosphory	Increased mitotic exit time

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for PPP2R2A

miRNA Products:		miRTarBase miRNAs that target PPP2R2A: hsa-mir-26b-5p (MIRT029553), hsa-mir-92a-3p (MIRT049716), hsa-let-7a-5p (MIRT052508), hsa-mir-1 (MIRT023787), hsa-mir-31-5p (MIRT000490), hsa-mir-222-3p (MIRT003191), hsa-mir-155-5p (MIRT020735), hsa-mir-30a-5p (MIRT028533), hsa-let-7b-5p (MIRT052126)

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		hsa-miR-361-5p hsa-miR-3146 hsa-miR-199a-3p hsa-miR-106a hsa-miR-4272 hsa-miR-605 hsa-miR-200a hsa-miR-374a

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R2A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
nucleus	2
extracellular	1
golgi apparatus	1
mitochondrion	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000159	protein phosphatase type 2A complex	IDA	17245430
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--

Find genes that share ontologies with PPP2R2A About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

SuperPaths for PPP2R2A About (see all 48)

See pathways by source

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by

SuperPath

Contained pathways About

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	0.67			G1 Phase	0.31
	Cell Cycle Control by BTG Proteins	0.36			Cyclin D associated events in G1	0.31

Cell Cycle, Mitotic

	Cell Cycle, Mitotic	0.90			M Phase	0.62
	Cell Cycle	0.90

p70S6K Signaling

	p70S6K Signaling	0.60			mTOR Pathway	0.54
	Renin-Angiotensin Pathway	0.60

Beta-Adrenergic Signaling

	Erythropoietin Pathway	0.37			CDK5 Pathway	0.36
	Beta-Adrenergic Signaling	0.37

Mitotic Metaphase and Anaphase

Mitotic Anaphase

0.94

Mitotic Metaphase and Anaphase

0.93

Find genes that share SuperPaths with PPP2R2A About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R2A (see all 25)

	Cell Cycle Control by BTG Proteins
	Telomerase Components in Cell Signaling
	CDK5 Pathway
	mTOR Pathway
	Cyclins and Cell Cycle Regulation

3 Cell Signaling Technology (CST) Pathways for PPP2R2A

	Phosphatases
	MAP Kinase Signaling
	Cell Cycle / Checkpoint Control

4 GeneGo (Thomson Reuters) Pathways for PPP2R2A

	Signal transduction PKA signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Selected BioSystems Pathways for PPP2R2A (see all 7)

	Wnt Signaling Pathway and Pluripotency
	Glycogen Metabolism
	TGF-beta Receptor Signaling Pathway
	IL-6 Signaling Pathway
	TGF-beta receptor signaling

4 Reactome Pathways for PPP2R2A

	Initiation of Nuclear Envelope Reformation
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
	Cyclin A/B1 associated events during G2/M transition
	Cyclin D associated events in G1

Selected Kegg Pathways (Kegg details for PPP2R2A) (see all 8):

	mRNA surveillance pathway
	PI3K-Akt signaling pathway
	Adrenergic signaling in cardiomyocytes
	Hippo signaling pathway
	Tight junction

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PPP2R2A
Interactions:

Search GeneGlobe Interaction Network for PPP2R2A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PPP2R2A (P63151^{1, 2, 3} ENSP00000370113⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 310)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2CA	P67775²^,³, ENSP00000418447⁴	MINT-8288206 I2D: score=4 STRING: ENSP00000418447
PPP2R1B	P30154¹^,³, ENSP00000311344⁴	EBI-1048931,EBI-357094 I2D: score=4 STRING: ENSP00000311344
TP53	P04637²^,³, ENSP00000269305⁴	MINT-4299164 I2D: score=1 STRING: ENSP00000269305
PPP2R1A	P30153¹^,²^,³, ENSP00000324804⁴	EBI-1048931,EBI-302388 MINT-4299261 MINT-8288206 I2D: score=5 STRING: ENSP00000324804
DAPK1	P53355²^,³, ENSP00000350785⁴	MINT-8204105 MINT-8204054 I2D: score=1 STRING: ENSP00000350785

About this table

Gene Ontology (GO): Selected biological process terms (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006470	protein dephosphorylation	IDA	1849734
GO:0007084	mitotic nuclear envelope reassembly	TAS	--

Find genes that share ontologies with PPP2R2A About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for PPP2R2A available from Tocris Bioscience About this table

Compound	Action	CAS #
Salubrinal	Selective inhibitor of eIF2alpha dephosphorylation	[405060-95-9]
FK 506	Potent calcineurin inhibitor; immunosuppressant	[104987-11-3]
Cyclosporin A	Calcineurin inhibitor	[59865-13-3]
Okadaic acid	Protein phosphatase 1 and 2A inhibitor	[78111-17-8]
Calyculin A	Protein phosphatase 1 and 2A inhibitor	[101932-71-2]

1 DrugBank Compound for PPP2R2A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	--	--	target	--	10592235

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for PPP2R2A gene (2 alternative transcripts):

NM_001177591.1 NM_002717.3

Unigene Cluster for PPP2R2A:

Protein phosphatase 2, regulatory subunit B, alpha

Hs.146339 [show with all ESTs]

Unigene Representative Sequence: CR936829

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000380737(uc003xek.3 uc003xeu.3 uc011laf.2) ENST00000518254

ENST00000520329 ENST00000524169 ENST00000518397 ENST00000522535 ENST00000522150

ENST00000523473 ENST00000521095 ENST00000523925 ENST00000524099 ENST00000519636

ENST00000315985 ENST00000522482 ENST00000521557 ENST00000519439 ENST00000521484

ENST00000523964

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Additional mRNA sequence:

AK095153.1 AK123721.1 AK303981.1 AK314823.1 AL050206.1 AY189686.1 BC041071.1 CR936829.1

M64929.1

Selected DOTS entries (see all 26):

DT.219041 DT.75116267 DT.441782 DT.100724149 DT.86859974 DT.219043 DT.100644265 DT.97789259

DT.120648760 DT.91755647 DT.91755648 DT.100774243 DT.100803367 DT.100803368 DT.91909912 DT.101987136

DT.120648707 DT.120648746 DT.100027522 DT.120648725 DT.120648755 DT.120648775 DT.86836063 DT.95277725

Selected AceView cDNA sequences (see all 332):

BM271867 BM699294 AA630349 NM_002717 BM782821 BQ433102 AA374830 BM786642

AI358643 BM669512 AA279630 CD109398 BM541466 BM853600 BU187051 BX117882

CB140965 BM850934 BE778171 AI571427 BI838168 CK821833 CD251910 AU119283

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP2R2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTATGGGATT

About this image

PPP2R2A expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Brain (Nervous System) fully expand to see all 12 entries
Thalamus
Septum

Blood (Hematopoietic System)
Granulocytes Peripheral Blood

PPP2R2A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PPP2R2A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.146339

UniProtKB/Swiss-Prot: 2ABA_HUMAN, P63151

Tissue specificity: Expressed in all tissues examined

Custom PCR Arrays for PPP2R2A

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2A gene from Selected species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ppp2r2a^{1 , 5}	protein phosphatase 2 (formerly 2A), regulatory subunit more⁵ protein phosphatase 2, regulatory subunit B, alpha¹	93.93(n)¹ 100(a)¹		14 (34.60 cM)⁵ 71978¹ NM_028032.3¹ NP_082308.1¹ 67014057⁵
chicken (Gallus gallus)	Aves	PPP2R2A¹	protein phosphatase 2, regulatory subunit B, alpha	89.14(n) 99.33(a)		419523 NM_001030886.1 NP_001026057.1
lizard (Anolis carolinensis)	Reptilia	PPP2R2A⁶	protein phosphatase 2, regulatory subunit B, alpha...	99(a)	1 ↔ 1	GL343445.1(608561-650890)
African clawed frog (Xenopus laevis)	Amphibia	Xl.734²	X.laevis mRNA PPA2 for 55 kDa regulatory subunit	81.22(n)		X80697.1
zebrafish (Danio rerio)	Actinopterygii	wufd19g04²	wufd19g04	78.1(n)		327263 BC056824.1
fruit fly (Drosophila melanogaster)	Insecta	tws³	imaginal disc pattern formation protein phosphatase more	79(a)		85F13 --
worm (Caenorhabditis elegans)	Secernentea	sur-6⁶	Protein SUR-6 (sur-6) mRNA, complete cds	60(a)	1 → many	I(9754122-9757898) WBGene00006352
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC55⁶	Non-essential regulatory subunit B of protein phos...	46(a)	1 → many	VII(145809-147389) YGL190C
soybean (Glycine max)	eudicotyledons	Gma.7239²	Transcribed sequence with moderate similarity to protein more	73.64(n)
rice (Oryza sativa)	Liliopsida	AF081923.1²	--	77.78(n)		AF081923.1

ENSEMBL Gene Tree for PPP2R2A (if available)
TreeFam Gene Tree for PPP2R2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PPP2R2A gene

PPP2R2D² PPP2R2B² PPP2R2C²

3 SIMAP similar genes for PPP2R2A using alignment to 6 protein entries: 2ABA_HUMAN (see all proteins):

PPP2R2D PPP2R2C PPP2R2B

Find genes that share paralogs with PPP2R2A About GenesLikeMe

1 Pseudogenes.org Pseudogene for PPP2R2A
PGOHUM00000245427

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117091380^1,2	C,F	--	26147021(+)	`GCATAC/TCCAGA`	1	--	us2k¹		1		NA	120
rs150645073^1,2	C	--	26147072(+)	`AGCACA/GCAGTG`	1	--	us2k¹		0	--	--	--	--
rs11781523^1,2	C,H	--	26147080(+)	`GTGCAC/GTGAAG`	1	--	us2k¹		1		NA	6
rs185619566^1,2		--	26147093(+)	`TTGTAA/CCTGTT`	1	--	us2k¹		0	--	--	--	--
rs140108495^1,2	C	--	26147164(+)	`GTAACA/GTGGGA`	1	--	us2k¹		0	--	--	--	--
rs190087341^1,2		--	26147178(+)	`ATTCAC/TGCAGA`	1	--	us2k¹		0	--	--	--	--
rs116453682^1,2	C,F	--	26147343(+)	`CCAAAC/AGCCTT`	1	--	us2k¹		1		WA	118
rs182282990^1,2		--	26147617(+)	`AACGGA/CAGCTA`	1	--	us2k¹		0	--	--	--	--
rs62494171^1,2	C,F	--	26147817(+)	`TGATCA/GCATAG`	1	--	us2k¹		2		NA	122
rs185026666^1,2		--	26147866(+)	`CCTACA/TGCAGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPP2R2A (26149007 - 26230196 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for PPP2R2A: About this table

Variant ID	Type	Subtype	PubMed ID
esv269537	CNV	Insertion	20981092
esv2495705	CNV	Insertion	19546169
esv273393	CNV	Insertion	20981092
nsv831273	CNV	Loss	17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604941 OMIM disorders: --

Find genes that share disorders with PPP2R2A About GenesLikeMe

Genetic Association Database (GAD): PPP2R2A
Human Genome Epidemiology (HuGE) Navigator: PPP2R2A (3 documents)

Export disorders for PPP2R2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PPP2R2A gene, integrated from 10 sources (see all 97):
(articles sorted by number of sources associating them with PPP2R2A)

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Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. (PubMed id 1849734)^{1, 2, 3} Mayer R.E.... Hemmings B.A. (Biochemistry 1991)
Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PubMed id 19890961)^{1, 4} Dupont W.D....Smith J.R. (Cancer 2010)
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)^{1, 2} Li H.H.... Liu X. (EMBO J. 2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Upregulation of miR-136 in human non-small cell lung cancer cells promotes Erk1/2 activation by targeting PPP2R2A. (PubMed id 23959478)¹ Shen S....Wang J. (Tumour Biol. 2014)
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)¹ Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)¹ Xie Y....Cong F. (J. Biol. Chem. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5520	HGNC: 9304	AceView: PPP2R2A	Ensembl:ENSG00000221914	euGenes: HUgn5520
ECgene: PPP2R2A	Kegg: 5520	H-InvDB: PPP2R2A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PPP2R2A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PPP2R2A	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PPP2R2A gene
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Patent Information for PPP2R2A gene:
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PPP2R2A Gene

Protein Phosphatase 2, Regulatory Subunit B, Alpha

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PPP2R2A Gene

Protein Phosphatase 2, Regulatory Subunit B, Alpha

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