Aliases for PPP2R2A Gene
Aliases for PPP2R2A Gene
- Protein Phosphatase 2 Regulatory Subunit Balpha 2 3 5
- PP2A Subunit B Isoform Alpha 2 4
- Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Alpha Isoform 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha Isoform 2
- Protein Phosphatase 2, Regulatory Subunit B, Alpha 3
- PP2A Subunit B Isoform PR55-Alpha 4
- PP2A Subunit B Isoform B55-Alpha 4
External Ids for PPP2R2A Gene
- HGNC: 9304
- Entrez Gene: 5520
- Ensembl: ENSG00000221914
- OMIM: 604941
- UniProtKB: P63151
Previous GeneCards Identifiers for PPP2R2A Gene
- GC08P025922
- GC08P026502
- GC08P026170
- GC08P025099
- GC08P024693
Summaries for PPP2R2A Gene
-
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R2A Gene
PPP2R2A (Protein Phosphatase 2 Regulatory Subunit Balpha) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway and Cyclins and Cell Cycle Regulation. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R2D.
UniProtKB/Swiss-Prot for PPP2R2A Gene
-
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
-
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
Additional gene information for PPP2R2A Gene
- Monarch Initiative
- Search for PPP2R2A at DataMed
- Search for PPP2R2A at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2A Gene
Genomics for PPP2R2A Gene
GeneHancer (GH) Regulatory Elements for PPP2R2A Gene
Promoters and enhancers for PPP2R2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PPP2R2A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PPP2R2A Gene
Genomic Locations for PPP2R2A Gene
- chr8:26,291,491-26,372,680
- (GRCh38/hg38)
- Size:
- 81,190 bases
- Orientation:
- Plus strand
- chr8:26,149,007-26,230,196
- (GRCh37/hg19)
Genomic View for PPP2R2A Gene
Genes around PPP2R2A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.2 by Ensembl
- 8p21.2 by Entrez Gene
- 8p21.2 by HGNC
PPP2R2A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP2R2A Gene
Proteins for PPP2R2A Gene
-
Protein details for PPP2R2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P63151-2ABA_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Protein Accession:
- P63151
- B2RBU8
- B4E1T7
- P50409
- Q00007
Protein attributes for PPP2R2A Gene
- Size:
- 447 amino acids
- Molecular mass:
- 51692 Da
- Quaternary structure:
-
- Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751).
Protein Expression for PPP2R2A Gene
Post-translational modifications for PPP2R2A Gene
- Ubiquitination at isoforms=2105
Other Protein References for PPP2R2A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for PPP2R2A (PPP2R2A)
-
Abcam antibodies for PPP2R2A
- Invitrogen Antibodies for PPP2R2A
- GeneTex PPP2R2A antibody for PPP2R2A
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R2A
Protein Products
-
OriGene Purified Proteins for PPP2R2A
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2R2A
- Origene Custom Protein Services for PPP2R2A
- Search GeneTex for Proteins for PPP2R2A
-
Abcam proteins for PPP2R2A
Assay Products
No data available for DME Specific Peptides for PPP2R2A Gene
Domains & Families for PPP2R2A Gene
Gene Families for PPP2R2A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP2R2A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP2R2A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P63151- Family:
-
- Belongs to the phosphatase 2A regulatory subunit B family.
Function for PPP2R2A Gene
Molecular function for PPP2R2A Gene
- GENATLAS Biochemistry:
- protein phosphatase 2 (formerly 2A),regulatory subunit B (PR52),alpha isoform
- UniProtKB/Swiss-Prot Function:
- The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Phenotypes From GWAS Catalog for PPP2R2A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004722 | protein serine/threonine phosphatase activity | TAS,IDA | -- |
| GO:0005515 | protein binding | IPI | 9847399 |
| GO:0019888 | protein phosphatase regulator activity | IEA,TAS | 1849734 |
| GO:0032403 | protein complex binding | IEA | -- |
| GO:0048156 | tau protein binding | IEA | -- |
Phenotypes for PPP2R2A Gene
- GenomeRNAi human phenotypes for PPP2R2A:
-
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death HMECs cells
- Increased Sindbis virus (SINV) infection
- Decreased Tat-dependent transcription
- Increased Erk phosphorylation after EGF stimulation
- Increased mitotic exit time
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2R2A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R2A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
- Search ViGene Biosciences for PPP2R2A
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R2A
- genomics-online: gRNA clones - Search results for 72 available PPP2R2A gene related products
- Overview of 72 available PPP2R2A gene related products
- Applied Biological Materials CRISPR for PPP2R2A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R2A
- GenScript: Design CRISPR guide RNA sequences for PPP2R2A
miRNA for PPP2R2A Gene
- miRTarBase miRNAs that target PPP2R2A
-
- hsa-mir-31-5p (MIRT000490)
- hsa-mir-222-3p (MIRT003191)
- hsa-mir-155-5p (MIRT020735)
- hsa-mir-1-3p (MIRT023787)
- hsa-mir-30a-5p (MIRT028533)
- hsa-mir-26b-5p (MIRT029553)
- hsa-mir-92a-3p (MIRT049716)
- hsa-let-7b-5p (MIRT052126)
- hsa-let-7a-5p (MIRT052508)
- hsa-mir-548t-5p (MIRT224722)
- hsa-mir-548az-5p (MIRT224728)
- hsa-mir-409-3p (MIRT322407)
- hsa-mir-551b-5p (MIRT322409)
- hsa-mir-605-3p (MIRT322410)
- hsa-mir-3910 (MIRT322413)
- hsa-mir-4796-3p (MIRT322414)
- hsa-let-7c-5p (MIRT322426)
- hsa-let-7d-5p (MIRT322427)
- hsa-let-7e-5p (MIRT322428)
- hsa-let-7f-5p (MIRT322429)
- hsa-mir-98-5p (MIRT322430)
- hsa-let-7g-5p (MIRT322431)
- hsa-let-7i-5p (MIRT322432)
- hsa-mir-4458 (MIRT322433)
- hsa-mir-4500 (MIRT322434)
- hsa-mir-218-5p (MIRT439914)
- hsa-mir-187-5p (MIRT506061)
- hsa-mir-154-5p (MIRT506062)
- hsa-mir-548t-3p (MIRT506063)
- hsa-mir-548ap-3p (MIRT506064)
- hsa-mir-548aa (MIRT506065)
- hsa-mir-3605-5p (MIRT561713)
- hsa-mir-3679-5p (MIRT561714)
- hsa-mir-1185-5p (MIRT561715)
- hsa-mir-4719 (MIRT561716)
- hsa-mir-4801 (MIRT561717)
- hsa-mir-4731-3p (MIRT561718)
- hsa-mir-101-3p (MIRT561719)
- hsa-mir-144-3p (MIRT561721)
- hsa-mir-3202 (MIRT566297)
- hsa-mir-4533 (MIRT566298)
- hsa-mir-556-5p (MIRT731778)
- hsa-mir-20a-5p (MIRT734854)
- hsa-mir-17-5p (MIRT734855)
- hsa-mir-1249-5p (MIRT736455)
- hsa-mir-1343-5p (MIRT737482)
- hsa-mir-143-3p (MIRT737603)
- hsa-mir-221-3p (MIRT739070)
- hsa-mir-3179 (MIRT740745)
- hsa-mir-363-5p (MIRT741840)
- hsa-mir-4274 (MIRT743663)
- hsa-mir-4459 (MIRT744836)
- hsa-mir-455-3p (MIRT746208)
- hsa-mir-4695-5p (MIRT747198)
- hsa-mir-4770 (MIRT748674)
- hsa-mir-5197-3p (MIRT750090)
- hsa-mir-548ao-3p (MIRT750555)
- hsa-mir-548v (MIRT750810)
- hsa-mir-555 (MIRT750895)
- hsa-mir-6081 (MIRT751776)
- hsa-mir-6088 (MIRT751940)
- hsa-mir-6515-5p (MIRT753295)
- hsa-mir-665 (MIRT753653)
- hsa-mir-6745 (MIRT754467)
- hsa-mir-6797-5p (MIRT756215)
- hsa-mir-6805-5p (MIRT756483)
- hsa-mir-6809-5p (MIRT756632)
- hsa-mir-6864-5p (MIRT757910)
- hsa-mir-6880-5p (MIRT758324)
- hsa-mir-7515 (MIRT759388)
- hsa-mir-766-5p (MIRT759656)
- hsa-mir-7847-3p (MIRT759862)
- hsa-mir-939-5p (MIRT760773)
miRNA Products
- Search ViGene Biosciences for PPP2R2A
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PPP2R2A
- Browse OriGene Inhibitory RNA Products For PPP2R2A
- genomics-online: shRNA clones - Search results for 72 available PPP2R2A gene related products
- Overview of 72 available PPP2R2A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
Clone Products
- Sino Biological Human cDNA Clone for PPP2R2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PPP2R2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R2A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPP2R2A
- Applied Biological Materials Clones for PPP2R2A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PPP2R2A
-
ViGene Biosciences adenoviral particle packaged cDNA for PPP2R2A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PPP2R2A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2A Gene
Localization for PPP2R2A Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | IDA,IEA | 1849734 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IBA,TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R2A Gene
Pathways & Interactions for PPP2R2A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cyclins and Cell Cycle Regulation |
.31
|
|
| 2 | Beta-Adrenergic Signaling |
.36
|
|
| 3 | p70S6K Signaling |
.60
|
.54
|
| 4 | Cell Cycle, Mitotic |
.83
|
.60
|
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for PPP2R2A Gene
2 Cell Signaling Technology pathways for PPP2R2A Gene
5 BioSystems pathways for PPP2R2A Gene
16 Reactome pathways for PPP2R2A Gene
11 KEGG pathways for PPP2R2A Gene
4 GeneGo (Thomson Reuters) pathways for PPP2R2A Gene
25 Qiagen pathways for PPP2R2A Gene
Interacting Proteins for PPP2R2A Gene
Selected Interacting proteins:
ENSP00000325074
P63151-2ABA_HUMAN
for PPP2R2A Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
| GO:0000278 | mitotic cell cycle | IBA | -- |
| GO:0006470 | protein dephosphorylation | IDA | 1849734 |
| GO:0007084 | mitotic nuclear envelope reassembly | TAS | -- |
No data available for SIGNOR curated interactions for PPP2R2A Gene
Drugs & Compounds for PPP2R2A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Antagonist | Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor | 0 | |
| 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| FK 506 |
|
104987-11-3 |
|
|
(4) Tocris Compounds for PPP2R2A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
| Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
| FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
| INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
Transcripts for PPP2R2A Gene
mRNA/cDNA for PPP2R2A Gene
- (9) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (332) Selected AceView cDNA sequences:
- (24) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPP2R2A Gene
CRISPR Products
-
OriGene CRISPR knockouts for PPP2R2A
- genomics-online: gRNA clones - Search results for 72 available PPP2R2A gene related products
- Overview of 72 available PPP2R2A gene related products
- Applied Biological Materials CRISPR for PPP2R2A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R2A
- GenScript: Design CRISPR guide RNA sequences for PPP2R2A
miRNA Products
- Search ViGene Biosciences for PPP2R2A
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PPP2R2A
- Browse OriGene Inhibitory RNA Products For PPP2R2A
- genomics-online: shRNA clones - Search results for 72 available PPP2R2A gene related products
- Overview of 72 available PPP2R2A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
Clone Products
- Sino Biological Human cDNA Clone for PPP2R2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PPP2R2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2R2A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPP2R2A
- Applied Biological Materials Clones for PPP2R2A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PPP2R2A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP2R2A Gene
NURSA nuclear receptor signaling pathways regulating expression of PPP2R2A Gene:
PPP2R2ASOURCE GeneReport for Unigene cluster for PPP2R2A Gene:
Hs.146339mRNA Expression by UniProt/SwissProt for PPP2R2A Gene:
P63151-2ABA_HUMAN
Tissue specificity:
Expressed in all tissues examined.
Evidence on tissue expression from TISSUES for PPP2R2A Gene
- Nervous system(4.8)
- Lung(4.5)
- Liver(4.3)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for PPP2R2A
-
OriGene qPCR primer pairs and template standards for PPP2R2A
- genomics-online: primer clones - Search results for 72 available PPP2R2A gene related products
- Overview of 72 available PPP2R2A gene related products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R2A Gene
Orthologs for PPP2R2A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP2R2A 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PPP2R2A 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2R2A 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PPP2R2A 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PPP2R2A 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppp2r2a 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ppp2r2a 33 |
|
||
| chicken (Gallus gallus) |
Aves | PPP2R2A 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PPP2R2A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp2r2a 33 |
|
||
| Str.6179 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.734 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp2r2ab 34 |
|
OneToMany | |
| PPP2R2A (2 of 2) 34 |
|
OneToMany | |||
| ppp2r2d 33 |
|
||||
| wufd19g04 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | tws 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sur-6 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC55 34 |
|
OneToMany | |
| soybean (Glycine max) |
eudicotyledons | Gma.7239 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3832 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.21357 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6047 34 |
|
OneToMany |
- Species where no ortholog for PPP2R2A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PPP2R2A Gene
(3) SIMAP similar genes for PPP2R2A Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for PPP2R2A Gene
Variants for PPP2R2A Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034981 | -- | 26,362,496(+) | C/T | intron_variant | |
| rs1000061152 | -- | 26,314,032(+) | A/C | intron_variant | |
| rs1000086513 | -- | 26,303,385(+) | A/G | intron_variant | |
| rs1000137222 | -- | 26,306,305(+) | G/A | intron_variant | |
| rs1000156121 | -- | 26,294,449(+) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2495705 | CNV | insertion | 19546169 |
| esv3305259 | CNV | mobile element insertion | 20981092 |
| esv3309120 | CNV | mobile element insertion | 20981092 |
| esv3324782 | CNV | insertion | 20981092 |
| esv3572648 | CNV | loss | 25503493 |
| esv3616666 | OTHER | inversion | 21293372 |
| esv3616698 | CNV | loss | 21293372 |
| esv3616699 | CNV | loss | 21293372 |
| nsv1076075 | CNV | deletion | 25765185 |
| nsv473268 | CNV | novel sequence insertion | 20440878 |
| nsv831273 | CNV | loss | 17160897 |
| nsv951118 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.31;
6.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP2R2A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP2R2A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2A Gene
Disorders for PPP2R2A Gene
Additional Disease Information for PPP2R2A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PPP2R2A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2A Gene
Publications for PPP2R2A Gene
- Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. (PMID: 1849734) Mayer RE … Hemmings BA (Biochemistry 1991) 2 3 4 58
- HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y … Sakurai H (FEBS letters 2015) 3 4 58
- Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PMID: 19890961) Dupont WD … Smith JR (Cancer 2010) 3 44 58
- A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. (PMID: 17245430) Li HH … Liu X (The EMBO journal 2007) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for PPP2R2A Gene
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PPP2R2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2R2A
- VectorBuilder custom plasmid, inducible vectors for PPP2R2A
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPP2R2A
- antibodies-online: Search results for 28 available PPP2R2A Antibodies ranked by validation data
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- GeneTex PPP2R2A antibody for PPP2R2A
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- ViGene Biosciences adenoviral particle packaged cDNA for PPP2R2A gene
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- ViGene Biosciences ready-to-package AAV shRNAs for PPP2R2A gene
- Search ViGene Biosciences for PPP2R2A
- Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R2A
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- Horizon Cell Lines for PPP2R2A
- genomics-online: cdna clones - Search results for 72 available PPP2R2A gene related products
- Overview of 72 available PPP2R2A gene related products
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Sources for PPP2R2A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (120) Genetics Home Reference
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew