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Aliases for PPP2R1B Gene

Aliases for PPP2R1B Gene

  • Protein Phosphatase 2, Regulatory Subunit A, Beta 2 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Beta Isoform 2 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta Isoform 2
  • Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta 3
  • PP2A, Subunit A, PR65-Beta Isoform 3
  • PP2A, Subunit A, R1-Beta Isoform 3
  • PP2A Subunit A Isoform PR65-Beta 4
  • PP2A Subunit A Isoform R1-Beta 4
  • Protein Phosphatase 2A 2
  • Regulatory Subunit A 2
  • Beta Isoform 2
  • PP2A-A-Beta 2
  • PP2A-Abeta 3
  • PR65B 3

External Ids for PPP2R1B Gene

Previous GeneCards Identifiers for PPP2R1B Gene

  • GC11M113950
  • GC11M113109
  • GC11M111631
  • GC11M111135
  • GC11M111102
  • GC11M107521
  • GC11M111613
  • GC11M111618
  • GC11M111634
  • GC11M111642
  • GC11M111656
  • GC11M111725

Summaries for PPP2R1B Gene

Entrez Gene Summary for PPP2R1B Gene

  • This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R1B Gene

PPP2R1B (Protein Phosphatase 2, Regulatory Subunit A, Beta) is a Protein Coding gene. Diseases associated with PPP2R1B include hereditary wilms' tumor and lung cancer. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include binding. An important paralog of this gene is PPP2R1A.

UniProtKB/Swiss-Prot for PPP2R1B Gene

  • The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit

Tocris Summary for PPP2R1B Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R1B Gene

Genomics for PPP2R1B Gene

Regulatory Elements for PPP2R1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPP2R1B Gene

Chromosome:
11
Start:
111,695,074 bp from pter
End:
111,766,445 bp from pter
Size:
71,372 bases
Orientation:
Minus strand

Genomic View for PPP2R1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R1B Gene

Proteins for PPP2R1B Gene

  • Protein details for PPP2R1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30154-2AAB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    Protein Accession:
    P30154
    Secondary Accessions:
    • A8MY67
    • B0YJ69
    • B4DGQ6
    • B4DK91
    • B4DWW5
    • F8W8G1
    • O75620
    • Q8NHV8

    Protein attributes for PPP2R1B Gene

    Size:
    601 amino acids
    Molecular mass:
    66214 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with SGOL1. Interacts with RAF1.
    SequenceCaution:
    • Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAG59103.1; Type=Frameshift; Positions=540; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP2R1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R1B Gene

Proteomics data for PPP2R1B Gene at MOPED

Post-translational modifications for PPP2R1B Gene

  • Ubiquitination at Lys 145, Lys 175, Lys 214, Lys 284, Lys 289, Lys 484, Lys 539, Lys 558, and Lys 573
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP2R1B Gene

Domains & Families for PPP2R1B Gene

Gene Families for PPP2R1B Gene

Protein Domains for PPP2R1B Gene

Graphical View of Domain Structure for InterPro Entry

P30154

UniProtKB/Swiss-Prot:

2AAB_HUMAN :
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure
  • Belongs to the phosphatase 2A regulatory subunit A family.
  • Contains 15 HEAT repeats.
Domain:
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure
Family:
  • Belongs to the phosphatase 2A regulatory subunit A family.
Similarity:
  • Contains 15 HEAT repeats.
genes like me logo Genes that share domains with PPP2R1B: view

Function for PPP2R1B Gene

Molecular function for PPP2R1B Gene

GENATLAS Biochemistry:
serine/threonine phosphatase 2 (formerly 2A),regulatory subunit A,beta isoform,65kDa,altered in human lung and colon carcinomas,see TSG11F,LOH11CR2A
UniProtKB/Swiss-Prot Function:
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit

Gene Ontology (GO) - Molecular Function for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 8392071
GO:0008601 protein phosphatase type 2A regulator activity IEA --
genes like me logo Genes that share ontologies with PPP2R1B: view
genes like me logo Genes that share phenotypes with PPP2R1B: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R1B Gene

Localization for PPP2R1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R1B Gene COMPARTMENTS Subcellular localization image for PPP2R1B gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045121 membrane raft IDA 21172653
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PPP2R1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R1B Gene

Pathways & Interactions for PPP2R1B Gene

SuperPathways for PPP2R1B Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 MyD88 cascade initiated on plasma membrane
3 S45 mutants of beta-catenin arent phosphorylated
4 Cyclins and Cell Cycle Regulation
.32
5 MAPK targets/ Nuclear events mediated by MAP kinases
genes like me logo Genes that share pathways with PPP2R1B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IEA --
GO:0034047 regulation of protein phosphatase type 2A activity IEA --
GO:0060561 apoptotic process involved in morphogenesis IMP 21172653
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP 21172653
genes like me logo Genes that share ontologies with PPP2R1B: view

No data available for SIGNOR curated interactions for PPP2R1B Gene

Drugs & Compounds for PPP2R1B Gene

(3) Drugs for PPP2R1B Gene - From: Tocris and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Pharma Inhibition, Inhibitor Immunosuppressive agent, Calcineurin inhibitor 0
serine Nutra 420
threonine Nutra 16

(5) Additional Compounds for PPP2R1B Gene - From: Tocris and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ceramide
3102-57-6
FK 506
104987-11-3
Fostriecin sodium salt
87860-39-7
Tautomycetin
119757-73-2
aspartate
genes like me logo Genes that share compounds with PPP2R1B: view

Transcripts for PPP2R1B Gene

Unigene Clusters for PPP2R1B Gene

Protein phosphatase 2, regulatory subunit A, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP2R1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for PPP2R1B Gene

GeneLoc Exon Structure for
PPP2R1B
ECgene alternative splicing isoforms for
PPP2R1B

Expression for PPP2R1B Gene

mRNA expression in normal human tissues for PPP2R1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP2R1B Gene

This gene is overexpressed in Liver (x14.1).

Protein differential expression in normal tissues from HIPED for PPP2R1B Gene

This gene is overexpressed in Bone (41.8), Testis (7.6), and Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R1B Gene



SOURCE GeneReport for Unigene cluster for PPP2R1B Gene Hs.584790

genes like me logo Genes that share expression patterns with PPP2R1B: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPP2R1B Gene

Orthologs for PPP2R1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2R1B 35
  • 91.64 (n)
  • 93.93 (a)
PPP2R1B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R1B 35
  • 91.91 (n)
  • 95.63 (a)
PPP2R1B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r1b 35
  • 87.96 (n)
  • 92.95 (a)
Ppp2r1b 16
Ppp2r1b 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R1B 35
  • 99.75 (n)
  • 99.55 (a)
PPP2R1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r1b 35
  • 88.89 (n)
  • 96.2 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R1B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R1B 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfb 35
  • 76.97 (n)
  • 88.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia ppp2r1b-prov 35
zebrafish
(Danio rerio)
Actinopterygii ppp2r1b 35
  • 74.21 (n)
  • 88.6 (a)
ppp2r1a 36
  • 88 (a)
OneToMany
ppp2r1b 36
  • 88 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pp2A-29B 37
  • 72 (a)
Pp2A-29B 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F48E8.5 37
  • 62 (a)
paa-1 36
  • 61 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPD3 36
  • 42 (a)
OneToMany
TPD3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PP2AA3 35
  • 57.36 (n)
  • 56.89 (a)
soybean
(Glycine max)
eudicotyledons Gma.7498 35
rice
(Oryza sativa)
Liliopsida Os09g0249700 35
  • 58.26 (n)
  • 57.91 (a)
corn
(Zea mays)
Liliopsida Zm.2099 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8422 36
  • 67 (a)
OneToMany
Species with no ortholog for PPP2R1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R1B Gene

ENSEMBL:
Gene Tree for PPP2R1B (if available)
TreeFam:
Gene Tree for PPP2R1B (if available)

Paralogs for PPP2R1B Gene

Paralogs for PPP2R1B Gene

(1) SIMAP similar genes for PPP2R1B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP2R1B: view

Variants for PPP2R1B Gene

Sequence variations from dbSNP and Humsavar for PPP2R1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14778 -- 111,741,547(-) AATTT(A/C)TAGTC utr-variant-3-prime, intron-variant
rs15503 -- 111,741,103(-) TGAAA(A/G)CCACA utr-variant-3-prime, intron-variant
rs561426 -- 111,733,403(+) TGGAT(A/G)AGCAG intron-variant
rs580191 -- 111,743,065(+) atttt(G/T)gtatt intron-variant
rs599441 -- 111,742,910(-) aaggc(A/C)aaact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R1B Gene

Variant ID Type Subtype PubMed ID
nsv832269 CNV Loss 17160897

Variation tolerance for PPP2R1B Gene

Residual Variation Intolerance Score: 70.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R1B Gene

HapMap Linkage Disequilibrium report
PPP2R1B
Human Gene Mutation Database (HGMD)
PPP2R1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R1B Gene

Disorders for PPP2R1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for PPP2R1B Gene - From: OMIM, ClinVar, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hereditary wilms' tumor
  • hereditary wilms tumor
lung cancer
  • lung cancer, protection against
endometrioid ovary carcinoma
  • endometrioid carcinoma ovary
colorectal cancer
  • colorectal cancer, somatic
- elite association

Relevant External Links for PPP2R1B

Genetic Association Database (GAD)
PPP2R1B
Human Genome Epidemiology (HuGE) Navigator
PPP2R1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R1B
genes like me logo Genes that share disorders with PPP2R1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R1B Gene

Publications for PPP2R1B Gene

  1. Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. (PMID: 9795170) Baysal B.E. … Richard C.W. III (Gene 1998) 2 23 67
  2. [Transcriptional regulation of genes involved in liver-selective cell communication]. (PMID: 18819872) Liao Z.J. … Zheng W.L. (Nan Fang Yi Ke Da Xue Xue Bao 2008) 23 67
  3. Alterations of tumour suppressor gene PPP2R1B in hepatocellular carcinoma. (PMID: 17324501) Chou H.C. … Sheu J.C. (Cancer Lett. 2007) 23 67
  4. Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. (PMID: 17343570) Yeh L.S. … Tsai F.J. (Int. J. Gynecol. Cancer 2007) 23 67
  5. Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B. (PMID: 17449237) Kalla C. … Lichter P. (Eur. J. Cancer 2007) 23 67

Products for PPP2R1B Gene

Sources for PPP2R1B Gene

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