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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPP2R1B Gene

protein-coding GIFtS: 65
GCID: GC11M111634

protein phosphatase 2, regulatory subunit A, beta

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)

Explore 33 diseases affiliated with
PPP2R1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Phosphatase 2, Regulatory Subunit A, Beta¹ ²		PP2A, Subunit A, R1-Beta Isoform²
PP2A-Abeta¹ ²		Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta²
PR65B¹ ²		Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Beta Isoform²
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Beta Isoform¹ ²		PP2A Subunit A Isoform PR65-Beta³
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta Isoform¹		PP2A Subunit A Isoform R1-Beta³
PP2A, Subunit A, PR65-Beta Isoform²

External Ids:	HGNC: 9303¹	Entrez Gene: 5519²	Ensembl: ENSG00000137713⁷	OMIM: 603113⁵	UniProtKB: P30154³

Export aliases for PPP2R1B gene to outside databases

Previous GC identifers: GC11M113950 GC11M113109 GC11M111631 GC11M111135 GC11M111102 GC11M107521 GC11M111613 GC11M111618

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R1B:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four

major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a

common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that

associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule

to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta

isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon

cancers. Alternatively spliced transcript variants have been described. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the

catalytic subunit and a variable regulatory B subunit

summary for PPP2R1B:

Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from

serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the

actions of kinases and phosphorylases and therefore play an integral role in many signal transduction

pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,

calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a

divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the

phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This

makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr

phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are

subtype-specific.

Gene Wiki entry for PPP2R1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPP2R1B gene promoter:
COUP-TF1 Pax-6 COUP XBP-1 HNF-4alpha2 Evi-1 HNF-4alpha1 RORalpha1 COUP-TF Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP2R1B promoter sequence

Search SABiosciences Chromatin IP Primers for PPP2R1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23.1

PPP2R1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R1B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M111634: view genomic region (about GC identifiers)

Start:	111,597,632 bp from pter	End:	111,637,169 bp from pter
Size:	39,538 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Size: 601 amino acids; 66214 Da

Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a

65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits.

Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,

R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell

signaling molecules. Interacts with IPO9. Interacts with SGOL1. Interacts with RAF1

Sequence caution: Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown

origin in the N-terminal part;

Secondary accessions: B0YJ69 B4DGQ6 B4DWW5 F8W8G1 O75620 Q8NHV8

Alternative splicing: 4 isoforms: P30154-1 P30154-2 P30154-3 P30154-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R1B: NX_P30154

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30154

PPP2R1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001171033.1 NP_001171034.1 NP_002707.3 NP_859050.1 NP_859051.1

ENSEMBL proteins:

ENSP00000311344 ENSP00000410671 ENSP00000437193 ENSP00000436626 ENSP00000343317

ENSP00000376775 ENSP00000433598 ENSP00000432666 ENSP00000434705 ENSP00000415759

Reactome Protein details: P30154
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030117	membrane coat	--	--

PPP2R1B for ontologies About GeneDecksing

PPP2R1B Antibody Products:

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Assay Products for PPP2R1B:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPP2R1B for domains About GeneDecksing

4 InterPro domains/families:

IPR011989 ARM-like

IPR021133 HEAT_type_2

IPR000357 HEAT

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry P30154

ProtoNet protein and cluster: P30154

1 Blocks protein family: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154

Domain: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop.

The repeat units may be arranged laterally to form a rod-like structure

Similarity: Belongs to the phosphatase 2A regulatory subunit A family

Similarity: Contains 15 HEAT repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the

catalytic subunit and a variable regulatory B subunit

Genatlas biochemistry entry for PPP2R1B:

serine/threonine phosphatase 2 (formerly 2A),regulatory subunit A,beta isoform,65kDa,altered in human lung and colon

carcinomas,see TSG11F,LOH11CR2A

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PPP2R1B Browse MicroRNA Expression Plasmids
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		hsa-miR-301b hsa-miR-519c-3p hsa-miR-301a hsa-miR-147 hsa-miR-519a hsa-miR-3666 hsa-miR-519b-3p hsa-miR-4295

		SwitchGear 3'UTR luciferase reporter plasmid: PPP2R1B 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R1B

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

PPP2R1B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PPP2R1B:

Increased apoptosis

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/50 super-pathways (see all 50) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

ERK/MAPK targets

ERK/MAPK targets	1.00	ERKs are inactivated	0.57
Nuclear Events (kinase and transcription factor activation)	0.88	PP2A-mediated dephosphorylation of key metabolic factors	0.22
MAPK targets/ Nuclear events mediated by MAP kinases	0.70	MASTL Facilitates Mitotic Progression	0.15

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	1.00			Cyclin D associated events in G1	0.32
	Cell Cycle Control by BTG Proteins	0.36			G1 Phase	0.32

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PPP2R1B

Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2R1B (see all 25)

	Cell Cycle Control by BTG Proteins
	Telomerase Components in Cell Signaling
	CDK5 Pathway
	mTOR Pathway
	Cyclins and Cell Cycle Regulation

2 GeneGo (Thomson Reuters) Pathways for PPP2R1B

	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

3 BioSystems Pathways for PPP2R1B

	Glycogen Metabolism
	Wnt Signaling Pathway and Pluripotency
	IL-6 Signaling Pathway

5/65 Reactome Pathways for PPP2R1B (see all 65)

	Mitotic Prometaphase
	Toll Like Receptor 2 (TLR2) Cascade
	Costimulation by the CD28 family
	Toll Like Receptor TLR6:TLR2 Cascade
	Platelet homeostasis

5/8 Kegg Pathways (Kegg details for PPP2R1B) (see all 8):

	mRNA surveillance pathway
	Oocyte meiosis
	Wnt signaling pathway
	TGF-beta signaling pathway
	Tight junction

PPP2R1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPP2R1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/673 Interacting proteins for PPP2R1B (P30154^{1, 2, 3} ENSP00000311344⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 673)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2CA	P67775¹^,²^,³, ENSP00000418447⁴	EBI-2559603,EBI-712311 MINT-8287178 I2D: score=5 STRING: ENSP00000418447
PPP2R5C	Q13362²^,³, ENSP00000333905⁴	MINT-2835624 I2D: score=5 STRING: ENSP00000333905
PPP2R2A	P63151¹^,³, ENSP00000370113⁴	EBI-2559603,EBI-2556013 I2D: score=4 STRING: ENSP00000370113
HDAC1	Q13547²^,³, ENSP00000362649⁴	MINT-7945693 I2D: score=3 STRING: ENSP00000362649
PPP2R5E	Q16537¹^,³, ENSP00000337641⁴	EBI-2559603,EBI-968374 I2D: score=3 STRING: ENSP00000337641

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	--	--
GO:0016192	vesicle-mediated transport	--	--
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	--

PPP2R1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPP2R1B for compounds About GeneDecksing

EMD Millipore small molecules for PPP2R1B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PPP2R1B available from Tocris Bioscience About this table

Compound	Action	CAS #
Cantharidin	Protein phosphatase 1 and 2A inhibitor	[56-25-7]
Okadaic acid	Protein phosphatase 1 and 2A inhibitor	[78111-17-8]
Calyculin A	Protein phosphatase 1 and 2A inhibitor	[101932-71-2]
Fostriecin sodium salt	Potent PP2A and PP4 inhibitor	[87860-39-7]

3 Novoseek chemical compound relationships for PPP2R1B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	41.2	3	10896920 (1), 16276521 (1), 9765152 (1)
serine	33.9	4	10896920 (1), 16276521 (1), 9765152 (1), 14767517 (1)
aspartate	17.1	1	16276521 (1)

Search CenterWatch for drugs/clinical trials and news about PPP2R1B / 2AAB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPP2R1B gene (5 alternative transcripts):

NM_001177562.1 NM_001177563.1 NM_002716.4 NM_181699.2 NM_181700.1

Unigene Cluster for PPP2R1B:

Protein phosphatase 2, regulatory subunit A, beta

Hs.584790 [show with all ESTs]

Unigene Representative Sequence: NM_002716

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311129(uc009yye.1 uc001plw.1 uc010rwi.1) ENST00000426998(uc009yyf.1)

ENST00000530787 ENST00000526287 ENST00000527614(uc001plx.1 uc010rwk.1 uc010rwl.1 uc010rwj.1)

ENST00000534521 ENST00000341980 ENST00000393055 ENST00000529672 ENST00000531890

ENST00000534500 ENST00000531373 ENST00000427203

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Additional cDNA sequence:

AF087438.1 AF163473.1 AK292275.1 AK293388.1 AK294716.1 AK296455.1 AK301705.1 BC027596.2

EF491803.1 M65254.1

15 DOTS entries:

DT.453780 DT.100799991 DT.100647153 DT.95169014 DT.95315557 DT.454694 DT.95169015 DT.40243343

DT.85105424 DT.97810948 DT.99949220 DT.100847120 DT.120739352 DT.120739428 DT.92445488

24/249 AceView cDNA sequences (see all 249):

NM_002716 CF132593 AI034287 CA308156 AA769580 AU280835 CA308184 F04139

H27269 BE277710 AI559380 NM_181699 BX951077 BQ230803 AI913263 BU617832

BM906510 BQ213614 BE766505 BQ215210 AW136215 AA491164 AU131747 AU131892

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1B (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18
SP1:									-																																						-
SP2:									-
SP3:									-		-		-
SP4:																																					-		-		-
SP5:									-				-

ECgene alternative splicing isoforms for PPP2R1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP2R1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAAGGGAC

About this image
See PPP2R1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP2R1B

SOURCE GeneReport for Unigene cluster: Hs.584790

SABiosciences Expression via Pathway-Focused PCR Arrays including PPP2R1B:

Parkinson's Disease in human mouse rat

Telomeres & Telomerase in human mouse rat

Prostate Cancer in human mouse rat

Apoptosis 384HT in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R1B gene from 6/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
African clawed frog (Xenopus laevis)	Amphibia	ppp2r1b-prov²	phosphorylase phosphatase	80.54(n)		BC043624.1
zebrafish (Danio rerio)	Actinopterygii	ppp2r1b¹	protein phosphatase 2 (formerly 2A), regulatory subunit more	74.23(n) 88.4(a)		449548 NM_001005590.1 NP_001005590.1
fruit fly (Drosophila melanogaster)	Insecta	Pp2A-29B³	protein amino acid dephosphorylation protein phosphatase more	72(a)		29B2 --
worm (Caenorhabditis elegans)	Secernentea	F48E8.5³	Protein phosphatase 2A	62(a)		III(5521881-5524543) --
thale cress (Arabidopsis thaliana)	eudicotyledons	RCN1¹	serine/threonine-protein phosphatase 2A regulatory more	58.04(n) 57.64(a)		839135 NM_102360.3 NP_173920.1
rice (Oryza sativa)	Liliopsida	--	HEAT repeat family protein, putative, expressed	57(a)	1 → many	9(3756920-3763491)

ENSEMBL Gene Tree for PPP2R1B (if available)
TreeFam Gene Tree for PPP2R1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PPP2R1B gene

PPP4R1² PPP4R1L² PPP2R1A²

1 SIMAP similar gene for PPP2R1B using alignment to 7 protein entries: 2AAB_HUMAN (see all proteins):

PPP2R1A

PPP2R1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61899391^1,2		--	107522365(+)	`GGACCA/GAAGTC`	2	--	int¹		2		NA	122
rs73564823^1,2	C,	--	107522594(+)	`TGTGGG/ACACTA`	2	--	int¹		2		WA	120
rs73564825^1,2	C,	--	107522657(+)	`AGTGGC/TGCTCC`	2	--	int¹		1		WA	2
rs12290773^1,2	H,	--	107522803(+)	`CCCATT/CCGACC`	2	--	int¹		4		NS EA	420
rs77936162^1,2		--	107522901(+)	`CACTCA/GAACTC`	2	--	int¹		0	--	--	--	--
rs71477001^1,2	C,	--	107523599(+)	`GCGACT/AGAGCA`	2	--	int¹		1		NA	2
rs11549309^1,2	C,H,	--	107524439(+)	`CAGCCG/ACCTGG`	2	--	int¹		3		NS NA	180
rs76638288^1,2		--	107524888(+)	`AAATAC/GAAGTA`	2	--	int¹		0	--	--	--	--
rs45629137^1,2	C,	--	107525313(+)	`AAAATT/CGGTGA`	2	--	int¹		1		NS	40
rs523612^1,2	H	--	107525362(-)	`CACATT/GGGAGC`	2	--	int¹		5		MN NS EA	600

HapMap Linkage Disequilibrium report for PPP2R1B (111597632 - 111637169 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPP2R1B: --
Human Gene Mutation Database (HGMD): PPP2R1B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PPP2R1B for disorders           About GeneDecksing

OMIM gene information: 603113
OMIM disorders: 211980
20/33 diseases for PPP2R1B (see all 33):    About MalaCards

colon cancer cerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3

mantle cell lymphoma paraganglioma chronic lymphocytic leukemia lymphocytic leukemia

wilms tumor cystic fibrosis squamous cell carcinoma chagas disease

hepatocellular carcinoma cervical cancer hepatitis c ovarian cancer

trypanosomiasis colorectal cancer carcinoma cerebritis

10/15 Novoseek disease relationships for PPP2R1B gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
allelic loss	57.8	1	10935485 (1)
somatic mutations	56.1	2	10935485 (1), 15672406 (1)
paraganglioma	49.2	2	9795170 (1)
colon cancer	44.5	5	10597236 (1), 10896920 (1), 11342371 (1), 9765152 (1) (see all 5)
ovarian cancer	38.1	6	10597236 (4), 10935485 (1)
colorectal cancer	36.3	7	14767517 (4), 10896920 (3)
cervical cancer	33.1	5	17343570 (3), 15672406 (1), 11118052 (1)
cancer lung	27.2	4	10597236 (1), 10935485 (1), 10337999 (1)
tumors	27	9	10597236 (2), 10935485 (2), 14767517 (2), 10942591 (1) (see all 6)
breast carcinoma	21.6	2	10713707 (1), 16276521 (1)

Genetic Association Database (GAD): PPP2R1B
Human Genome Epidemiology (HuGE) Navigator: PPP2R1B (5 documents)

Export disorders for PPP2R1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PPP2R1B gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with PPP2R1B)

Utopia: connect your pdf to the dynamic
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Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. (PubMed id 9795170)^{1, 2, 3, 9} Baysal B.E.... Richard C.W. III (1998)
Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. (PubMed id 2159327)^{1, 2, 3} Hemmings B.A.... Stone S.R. (1990)
Absence of PPP2R1B gene alterations in primary ovarian cancers. (PubMed id 10597236)^{1, 2, 9} Campbell I.G. and Manolitsas T. (1999)
Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. (PubMed id 10896920)^{1, 2, 9} Takagi Y.... Saji S. (2000)
Alterations of the PPP2R1B gene in human lung and colon cancer. (PubMed id 9765152)^{1, 2, 9} Wang S.S....Evans G.A. (1998)
The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. (PubMed id 16276521)^{1, 4, 9} Esplin E.D....Evans G.A. (2006)
Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. (PubMed id 11996789)^{1, 2, 9} Hemmer S.... Joensuu H. (2002)
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. (PubMed id 11313745)^{1, 2, 9} Baysal B.E.... Devlin B. (2001)
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)^{1, 2} Kitajima T.S.... Watanabe Y. (2006)
Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PubMed id 12670497)^{1, 2} Lubert E.J. and Sarge K.D. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5519	HGNC: 9303	AceView: PPP2R1B	Ensembl:ENSG00000137713	euGenes: HUgn5519
ECgene: PPP2R1B	Kegg: 5519	H-InvDB: PPP2R1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PPP2R1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PPP2R1B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PPP2R1B gene
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Patent Information for PPP2R1B gene:
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PPP2R1B Gene

protein phosphatase 2, regulatory subunit A, beta

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PPP2R1B Gene

protein phosphatase 2, regulatory subunit A, beta

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