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PPP2R1B Gene

protein-coding   GIFtS: 68
GCID: GC11M111656

Protein Phosphatase 2, Regulatory Subunit A, Beta

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit A, Beta1 2     PR65B2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Beta Isoform1 2     PP2A, Subunit A, PR65-Beta Isoform2
PP2A-A-beta1     PP2A, Subunit A, R1-Beta Isoform2
Beta Isoform1     Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta2
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta
Isoform1
     Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Beta
Isoform2
Protein Phosphatase 2A1     PP2A Subunit A Isoform PR65-Beta3
Regulatory Subunit A1     PP2A Subunit A Isoform R1-Beta3
PP2A-Abeta2     

External Ids:    HGNC: 93031   Entrez Gene: 55192   Ensembl: ENSG000001377137   OMIM: 6031135   UniProtKB: P301543   

Export aliases for PPP2R1B gene to outside databases

Previous GC identifers: GC11M113950 GC11M113109 GC11M111631 GC11M111135 GC11M111102 GC11M107521 GC11M111613 GC11M111618 GC11M111634 GC11M111642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R1B Gene:
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four
major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists
of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit,
that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding
molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene
encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with
some lung and colon cancers. Alternatively spliced transcript variants have been described. (provided by RefSeq,
Apr 2010)

GeneCards Summary for PPP2R1B Gene:
PPP2R1B (protein phosphatase 2, regulatory subunit A, beta) is a protein-coding gene. Diseases associated with PPP2R1B include lung cancer, and cerebral cavernous malformations 3. An important paralog of this gene is PPP2R1A.

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154
Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly
of the catalytic subunit and a variable regulatory B subunit

summary for PPP2R1B Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R1B gene promoter:
         COUP-TF1   Pax-6   COUP   XBP-1   HNF-4alpha2   Evi-1   HNF-4alpha1   RORalpha1   COUP-TF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP2R1B promoter sequence
   Search Chromatin IP Primers for PPP2R1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

PPP2R1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R1B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M111656:  view genomic region     (about GC identifiers)

Start:
111,597,632 bp from pter      End:
111,637,169 bp from pter
Size:
39,538 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform  
Size: 601 amino acids; 66214 Da
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C)
and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Interacts with IPO9. Interacts with SGOL1. Interacts with RAF1
Sequence caution: Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=BAG59103.1; Type=Frameshift; Positions=540;
Secondary accessions: A8MY67 B0YJ69 B4DGQ6 B4DK91 B4DWW5 F8W8G1 O75620 Q8NHV8
Alternative splicing: 5 isoforms:  P30154-1   P30154-2   P30154-3   P30154-4   P30154-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPP2R1B: NX_P30154

Explore proteomics data for PPP2R1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46, Lys145, Lys175, Lys200, Lys214, Lys267, Lys284, Lys289, Lys428, Lys484,
                                 Lys539, Lys554, Lys558, Lys573
  • Modification sites at PhosphoSitePlus

  • See PPP2R1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001171033.1  NP_001171034.1  NP_002707.3  NP_859050.1  NP_859051.1  

    ENSEMBL proteins: 
     ENSP00000311344   ENSP00000410671   ENSP00000437193   ENSP00000436626   ENSP00000343317  
     ENSP00000376775   ENSP00000433598   ENSP00000432666   ENSP00000434705   ENSP00000415759  
    Reactome Protein details: P30154

    PPP2R1B Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PPP2R1B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PPP2R1B
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    Novus Biologicals PPP2R1B Proteins
    Novus Biologicals PPP2R1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PPP2R1B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2R1B
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    OriGene Custom Antibody Services for PPP2R1B
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    Abcam antibodies for PPP2R1B
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    LSBio Antibodies in human, mouse, rat for PPP2R1B

    PPP2R1B Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR000357 HEAT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P30154

    ProtoNet protein and cluster: P30154

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154
    Domain: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat
    loop. The repeat units may be arranged laterally to form a rod-like structure
    Similarity: Belongs to the phosphatase 2A regulatory subunit A family
    Similarity: Contains 15 HEAT repeats


    PPP2R1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2AAB_HUMAN, P30154
    Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly
    of the catalytic subunit and a variable regulatory B subunit

         Genatlas biochemistry entry for PPP2R1B:
    serine/threonine phosphatase 2 (formerly 2A),regulatory subunit A,beta isoform,65kDa,altered in human lung and
    colon carcinomas,see TSG11F,LOH11CR2A

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16456541
         
    PPP2R1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPP2R1B:
     Increased apoptosis  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPP2R1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP2R1B:
    hsa-mir-16-5p (MIRT051305), hsa-mir-423-3p (MIRT042516), hsa-mir-7-5p (MIRT025691), hsa-mir-124-3p (MIRT022210)

    Block miRNA regulation of human, mouse, rat PPP2R1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R1B (see all 11):
    hsa-miR-301b hsa-miR-519c-3p hsa-miR-301a hsa-miR-147 hsa-miR-519a hsa-miR-3666 hsa-miR-519b-3p hsa-miR-4295
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP2R1B
    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP2R1B

    Clone
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    OriGene ORF clones in mouse, rat for PPP2R1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PPP2R1B (NM_181699)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R1B

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045121membrane raft IDA--

    PPP2R1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R1B About   (see all 56)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    Cell Cycle Control by BTG Proteins0.36
    Cyclin D associated events in G10.31
    2CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    CTLA4 inhibitory signaling0.32
    3Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    DARPP-32 events0.32
    4Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    5MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    ERKs are inactivated0.00
    MAPK targets/ Nuclear events mediated by MAP kinases0.80

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R1B (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    2 GeneGo (Thomson Reuters) Pathways for PPP2R1B
        Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    3 BioSystems Pathways for PPP2R1B
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway

    Selected Reactome Pathways for PPP2R1B (see all 18)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    ERKs are inactivated
    DARPP-32 events
    Cyclin A/B1 associated events during G2/M transition


    Selected Kegg Pathways  (Kegg details for PPP2R1B) (see all 11):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TGF-beta signaling pathway


    PPP2R1B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2R1B: 
              Parkinson's Disease in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP2R1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R1B (P301541, 2, 3 ENSP000003113444) via UniProtKB, MINT, STRING, and/or I2D (see all 739)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677751, 2, 3, ENSP000004184474EBI-357094,EBI-712311 MINT-8287178 I2D: score=5 STRING: ENSP00000418447
    PPP2R5CQ133621, 2, 3, ENSP000003339054EBI-357094,EBI-1266156 MINT-2835624 I2D: score=5 STRING: ENSP00000333905
    PPP2R2AP631511, 3, ENSP000003701134EBI-357094,EBI-1048931 I2D: score=4 STRING: ENSP00000370113
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 I2D: score=3 STRING: ENSP00000362649
    PPP2R5EQ165371, 3, ENSP000003376414EBI-357094,EBI-968374 I2D: score=3 STRING: ENSP00000337641
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0060561apoptotic process involved in morphogenesis IMP--
    GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP--

    PPP2R1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PPP2R1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    3 Novoseek inferred chemical compound relationships for PPP2R1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 41.2 3 10896920 (1), 16276521 (1), 9765152 (1)
    serine 33.9 4 10896920 (1), 16276521 (1), 9765152 (1), 14767517 (1)
    aspartate 17.1 1 16276521 (1)



    PPP2R1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP2R1B gene (5 alternative transcripts): 
    NM_001177562.1  NM_001177563.1  NM_002716.4  NM_181699.2  NM_181700.1  

    Unigene Cluster for PPP2R1B:

    Protein phosphatase 2, regulatory subunit A, beta
    Hs.584790  [show with all ESTs]
    Unigene Representative Sequence: NM_002716
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311129(uc009yye.1 uc001plw.1 uc010rwi.1) ENST00000426998(uc009yyf.1)
    ENST00000530787 ENST00000526287 ENST00000527614(uc001plx.1 uc010rwk.1 uc010rwl.1 uc010rwj.1)
    ENST00000534521 ENST00000341980 ENST00000393055 ENST00000529672 ENST00000531890
    ENST00000534500 ENST00000531373 ENST00000427203
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPP2R1B (see all 11):
    hsa-miR-301b hsa-miR-519c-3p hsa-miR-301a hsa-miR-147 hsa-miR-519a hsa-miR-3666 hsa-miR-519b-3p hsa-miR-4295
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R1B 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 5): PPP2R1B (NM_181699)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2R1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2R1B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPP2R1B
      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R1B
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R1B

    Additional mRNA sequence: 

    AF087438.1 AF163473.1 AK292275.1 AK293388.1 AK294716.1 AK296455.1 AK301705.1 BC027596.2 
    EF491803.1 M65254.1 

    15 DOTS entries:

    DT.453780  DT.100799991  DT.100647153  DT.95169014  DT.95315557  DT.454694  DT.95169015  DT.40243343 
    DT.85105424  DT.97810948  DT.99949220  DT.100847120  DT.120739352  DT.120739428  DT.92445488 

    Selected AceView cDNA sequences (see all 249):

    CR617223 AA769580 AW136215 BU617832 BX951077 BI087845 BM462294 BM906510 
    BE766505 CA308156 BF149339 BQ932075 BQ773499 CF132593 AU131747 CA308184 
    BG718830 BE277710 AA491164 AU280835 BQ215210 NM_002716 AI251884 BE018689 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1B (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                          -                                                                                                                 -               
    SP2:                          -                                                                                                                                 
    SP3:                          -     -     -                                                                                                                     
    SP4:                                                                                                              -     -     -                                 
    SP5:                          -           -                                                                                                                     


    ECgene alternative splicing isoforms for PPP2R1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2R1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGGGAC
    PPP2R1B Expression
    About this image


    PPP2R1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PPP2R1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584790
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2R1B: 
              Parkinson's Disease in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R1B gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r1b1 , 5 protein phosphatase 2 (formerly 2A), regulatory subunit more5
    protein phosphatase 2, regulatory subunit A, beta1
    87.96(n)1
    92.95(a)1
      9 (27.75 cM)5
    736991  NM_001286553.11  NP_001273482.11 
     508453015 
    African clawed frog
    (Xenopus laevis)
    Amphibia ppp2r1b-prov2 phosphorylase phosphatase 80.54(n)    BC043624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppp2r1b1 protein phosphatase 2 (formerly 2A), regulatory subunit more 74.21(n)
    88.6(a)
      449548  NM_001005590.1  NP_001005590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pp2A-29B3 protein amino acid dephosphorylation
    protein phosphatase more
    72(a)   29B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea F48E8.53 Protein phosphatase 2A 62(a)   III(5521881-5524543)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPD3(YAL016W)4 Regulatory subunit A of the heterotrimeric protein more   --   1(124879-126786) 851217  NP_009386.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PP2AA31 PP2AA3 57.36(n)
    56.89(a)
      837892  NM_101203.4  NP_172790.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g02497001 Os09g0249700 58.26(n)
    57.91(a)
      4346507  NM_001069209.1  NP_001062674.1 


    ENSEMBL Gene Tree for PPP2R1B (if available)
    TreeFam Gene Tree for PPP2R1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R1B gene
    PPP2R1A2  
    1 SIMAP similar gene for PPP2R1B using alignment to 6 protein entries:     2AAB_HUMAN (see all proteins):
    PPP2R1A

    PPP2R1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2R1B (see all 857)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18050761,2,,4
    C,FA lung cancer patient4 pathogenic1111498909(-) CACTGG/ACCTAG 9 /D /G mis1 int15Minor allele frequency- A:0.01NA EU 6009
    rs1427713261,2,,4
    C,FA lung cancer patient4 --111500407(+) GGTCCC/GGAGCT 10 R G mis11Minor allele frequency- G:0.00NA 4542
    VAR_0229004
    A colorectal cancer patient4--see VAR_0229002 S P mis40--------
    VAR_0229044
    A colorectal cancer patient4--see VAR_0229042 V G mis40--------
    VAR_0228994
    A lung cancer patient4--see VAR_0228992 K E mis40--------
    VAR_0228984
    A colon adenocarcinoma4--see VAR_0228982 L P mis40--------
    VAR_0229034
    A colorectal cancer patient4--see VAR_0229032 L I mis40--------
    VAR_0228964
    A colorectal cancer patient4--see VAR_0228962 G A mis40--------
    VAR_0229054
    A lung cancer patient4--see VAR_0229052 D G mis40--------
    VAR_0229024
    A colorectal cancer patient4--see VAR_0229022 V E mis40--------

    HapMap Linkage Disequilibrium report for PPP2R1B (111597632 - 111637169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPP2R1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832269CNV Loss17160897

    Human Gene Mutation Database (HGMD): PPP2R1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2R1B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603113   
    OMIM disorders: 211980  
    Selected diseases for PPP2R1B (see all 30):    
    About MalaCards
    lung cancer    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    paraganglioma    trypanosomiasis    cervical cancer    chagas disease
    mantle cell lymphoma    wilms tumor    cervicitis    cerebritis
    colorectal cancer    cystic fibrosis    ovarian cancer    hepatitis c
    hepatocellular carcinoma    hiv-1    chronic lymphocytic leukemia    hepatitis


    PPP2R1B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PPP2R1B gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allelic loss 57.8 1 10935485 (1)
    somatic mutations 56.1 2 10935485 (1), 15672406 (1)
    paraganglioma 49.2 2 9795170 (1)
    colon cancer 44.5 5 10597236 (1), 10896920 (1), 11342371 (1), 9765152 (1) (see all 5)
    ovarian cancer 38.1 6 10597236 (4), 10935485 (1)
    colorectal cancer 36.3 7 14767517 (4), 10896920 (3)
    cervical cancer 33.1 5 17343570 (3), 15672406 (1), 11118052 (1)
    cancer lung 27.2 4 10597236 (1), 10935485 (1), 10337999 (1)
    tumors 27 9 10597236 (2), 10935485 (2), 14767517 (2), 10942591 (1) (see all 6)
    breast carcinoma 21.6 2 10713707 (1), 16276521 (1)

    Genetic Association Database (GAD): PPP2R1B
    Human Genome Epidemiology (HuGE) Navigator: PPP2R1B (5 documents)

    Export disorders for PPP2R1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R1B gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with PPP2R1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. (PubMed id 9795170)1, 2, 3, 9 Baysal B.E.... Richard C.W. III (Gene 1998)
    2. Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. (PubMed id 2159327)1, 2, 3 Hemmings B.A.... Stone S.R. (Biochemistry 1990)
    3. Absence of PPP2R1B gene alterations in primary ovarian cancers. (PubMed id 10597236)1, 2, 9 Campbell I.G. and Manolitsas T. (Oncogene 1999)
    4. Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. (PubMed id 17343570)1, 4, 9 Yeh L.S....Tsai F.J. (Int. J. Gynecol. Cancer 2007)
    5. Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. (PubMed id 10896920)1, 2, 9 Takagi Y.... Saji S. (Gut 2000)
    6. Alterations of the PPP2R1B gene in human lung and colon cancer. (PubMed id 9765152)1, 2, 9 Wang S.S....Evans G.A. (Science 1998)
    7. The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. (PubMed id 16276521)1, 4, 9 Esplin E.D....Evans G.A. (amp 2006)
    8. Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. (PubMed id 11996789)1, 2, 9 Hemmer S.... Joensuu H. (Cancer Genet. Cytogenet. 2002)
    9. A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. (PubMed id 11313745)1, 2, 9 Baysal B.E.... Devlin B. (Eur. J. Hum. Genet. 2001)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5519 HGNC: 9303 AceView: PPP2R1B Ensembl:ENSG00000137713 euGenes: HUgn5519
    ECgene: PPP2R1B Kegg: 5519 H-InvDB: PPP2R1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2R1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2R1B gene:
    Search GeneIP for patents involving PPP2R1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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