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PPP2R1B Gene

protein-coding GIFtS: 72

GC11M111102

protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC26454 ^²
PP2A-A-beta ^²
PR65B ^¹, ²

Descriptions
PP2A, subunit A, PR65-beta isoform ^², ³
PP2A, subunit A, R1-beta isoform ^², ³
beta isoform of regulatory subunit A, protein phosphatase 2 ^²
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform ^¹
protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform ^²
protein phosphatase 2, structural/regulatory subunit A, beta ^²
serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta isoform ^²

External Ids
HGNC: 9303¹
Entrez Gene: 5519²
UniProtKB: P30154³
Ensembl: ENSG00000137713⁷

Search outside databases for aliases for PPP2R1B gene

Previous GC identifers: GC11M113950 GC11M113109 GC11M111631 GC11M111135

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PPP2R1B:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is

one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell

growth and division. It consists of a common heteromeric core enzyme, which is composed of a

catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory

subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the

assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta

isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung

and colon cancers. At least two transcript variants encoding different isoforms have been found

for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate

the assembly of the catalytic subunit and a variable regulatory B subunit

Gene Wiki entry for PPP2R1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PPP2R1B gene

Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23.1

PPP2R1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M111102: (about GC identifiers)

Start:	111,102,842 bp from pter
End:	111,142,379 bp from pter
Size:	39,538 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Size: 601 amino acids; 66214 Da

Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic

subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates

with a variety of regulatory subunits. Proteins that associate with the core dimer include three

families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56

families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Interacts with IPO9. Interacts with SGOL1

Sequence caution: Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Sequence of unknown origin in the N-terminal part;

Secondary accessions: O75620 Q8NHV8

Alternative splicing: 2 isoforms: P30154-1 P30154-2

REFSEQ proteins (2 alternative transcripts):

NP_002707.3 NP_859050.1

ENSEMBL proteins:

ENSP00000311344 ENSP00000343317 ENSP00000376775

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PPP2R1B
	Recombinant Proteins from Abcam (PPP2R1B)
	Human Recombinant Proteins from Abnova (PPP2R1B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for PPP2R1B:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PPP2R1B
	Sigma-Aldrich Antibodies for PPP2R1B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PPP2R1B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PPP2R1B)
	Novus Biologicals Antibodies for PPP2R1B

Assays for PPP2R1B:

	Invitrogen Assays for PPP2R1B
	Millipore Kits and Assays for the Analysis of PPP2R1B
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P30154

ProtoNet protein and cluster: P30154

1 Blocks protein family: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154

Domain: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region,

the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure

Similarity: Belongs to the phosphatase 2A regulatory subunit A family

Similarity: Contains 15 HEAT repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PPP2R1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPP2R1B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002716

Applied Biosystems Silencer® siRNAs for PPP2R1B

Sigma-Aldrich siRNA and siRNA Panels for PPP2R1B

Sigma-Aldrich shRNA Panels and shRNA for PPP2R1B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PPP2R1B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002716
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002716
untagged cDNA clones in CMV expression vector (see all 2): NM_002716

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_181699

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate

the assembly of the catalytic subunit and a variable regulatory B subunit

Genatlas biochemistry entry for PPP2R1B:

serine/threonine phosphatase 2 (formerly 2A),regulatory subunit A,beta isoform,65kDa,altered in

human lung and colon carcinomas,see TSG11F,LOH11CR2A

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003823	antigen binding	ISS	--
GO:0005515	protein binding	ISS	--
GO:0046982	protein heterodimerization activity	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/13 Sigma-Aldrich "Your Favorite Gene" Pathways for PPP2R1B (Your Favorite Gene powered by Ingenuity) (see all 13 )

Cell Cycle Regulation by BTG Family Proteins
Dopamine Receptor Signaling
CTLA4 Signaling in Cytotoxic T Lymphocytes
Synaptic Long Term Depression
Ceramide Signaling

GeneDecks PPP2R1B for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PPP2R1B

5/47 Interacting proteins for PPP2R1B (ENSP00000311344³ P30154^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2CA	P67775¹	STRING (score=.998) EBI-357094, EBI-712311
PPP2R5A	Q15172¹	STRING (score=.994) EBI-357094, EBI-641666
PPP2R5D	Q14738¹	STRING (score=.79) EBI-357094, EBI-396563
PPP2R5E	Q16537¹	STRING (score=.789) EBI-357094, EBI-968374
PPP2R5C	Q13362¹^,²	STRING (score=.988) EBI-357094, EBI-1266156 MINT-2835624 EBI-357094, EBI-1266156 MINT-2835624

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for PPP2R1B

Sigma-Aldrich Small Molecules for PPP2R1B:

Inhibitor

Compounds for PPP2R1B available from Tocris Bioscience

Compound	Action	CAS number
Cantharidin	Protein phosphatase 1 and 2A inhibitor	[56-25-7]
Okadaic acid	Protein phosphatase 1 and 2A inhibitor	[78111-17-8]
Calyculin A	Protein phosphatase 1 and 2A inhibitor	[101932-71-2]

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1 Novoseek chemical compound relationship for PPP2R1B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	41.93	3	10896920 (1), 16276521 (1), 9765152 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PPP2R1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPP2R1B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002716

Sigma-Aldrich siRNA and siRNA Panels for PPP2R1B

Sigma-Aldrich shRNA Panels and shRNA for PPP2R1B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002716 NM_181699

REFSEQ mRNAs for PPP2R1B gene (2 alternative transcripts):

NM_002716.4 NM_181699.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002716 NM_181699

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002716
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002716
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002716

Additional cDNA sequence:

AF087438.1 AF163473.1 AK292275.1 AK293388.1 AK294716.1 AK296455.1 AK301705.1 BC027596.2

CR617223.1 EF491803.1 EF491816.1 M65254.1

15 DOTS entries:

DT.453780 DT.100799991 DT.100647153 DT.95169014 DT.99949220 DT.454694 DT.95315557 DT.95169015

DT.40243343 DT.85105424 DT.97810948 DT.100847120 DT.120739352 DT.120739428 DT.92445488

24/249 AceView cDNA sequences (see all 249 ):

BQ438877 AI559380 BQ773499 H27269 BF149339 AW136215 BE766505 AF087438

CF132593 BQ213614 AA491164 BM708361 F04139 CA308184 BM462294 BU507259

BE018689 BQ215210 AI251884 AU131892 CA308156 AI206073 AA769580 BP371337

highest scoring ESTs for PPP2R1B:

M65254 AF087438 AF163473 AU280835 AV747834 AW505257 BC027596 BG718830 BI087845 BI459967

Unigene Cluster for PPP2R1B:

Protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform

Hs.584790 [show with all ESTs]

Unigene Representative Sequence: NM_002716

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1B (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18
SP1:									-																																						-
SP2:									-
SP3:									-		-		-
SP4:																																					-		-		-
SP5:									-				-

About this scheme

ECgene alternative splicing isoforms for PPP2R1B

3 Ensembl transcripts including schematic representations:

ENST00000311129 ENST00000341980 ENST00000393055

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PPP2R1B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PPP2R1B

¹ / ² / ³

19 probe-sets matching PPP2R1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65332_g_at²^{, 3}	U95-C	1	1.00	1.00	0.88	0.76	AW009884	0.60	1.00	0.82	1
41429_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.89	M65254	1.00	1.00	1.00	1
65331_at²^{, 3}	U95-C	1	1.00	1.00	0.28	0.91	AW009884	0.60	1.00	0.82	1
1093_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.57	M65254	1.00	1.00	1.00	1
56320_at²^{, 3}	U95-B	1	1.00	1.00	0.90	1.15	T79584	0.60	1.00	0.82	1
1094_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.00	M65254	1.00	1.00	1.00	1
72441_at²^{, 3}	U95-D	1	1.00	1.00	-0.15	0.74	H27731	0.80	1.00	0.91	1
53816_i_at²^{, 3}	U95-C	1	0.80	1.00	0.17	1.63	R76636	0.20	1.00	0.72	1
54307_r_at²^{, 3}	U95-C	1	0.75	1.00	0.54	1.42	R76636	0.20	1.00	0.72	1
202886_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M65254	1.00	1.00	1.00	1
202885_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF163473	0.80	1.00	0.91	1
202883_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	T79584	0.60	1.00	0.82	1
202884_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002716	0.60	1.00	0.82	1
222351_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW009884	0.60	1.00	0.82	1
202886_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202885_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202883_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202884_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222351_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PPP2R1B for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGAAGGGAC

SOURCE GeneReport for Unigene cluster: Hs.584790
Expression variation in blood from EXPOLDB for PPP2R1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PPP2R1B gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PPP2R1B¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	91.14(n) 94.47(a)	479444 XM_845791.1 XP_850884.1
chimpanzee (Pan troglodytes)	PPP2R1B¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	95.49(n) 94.26(a)	466778 XM_522178.2 XP_522178.2
rat (Rattus norvegicus)	Ppp2r1b¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	88.7(n) 95.66(a)	315648 NM_001025418.1 NP_001020589.1
mouse (Mus musculus)	Ppp2r1b^{1, 5}	9⁵	protein phosphatase 2 (formerly 2A), regulatory subunit more^{1, 5}	88.23(n)¹ 94.35(a)¹	73699¹ NM_001034085.1¹ NP_001029257.1¹ AI790395⁵ AK010754⁵ (see all 14)
chicken (Gallus gallus)	PPP2R1B¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	78.74(n) 98.28(a)	777130 XM_001236601.1 XP_001236602.1

About this table Species with no ortholog for PPP2R1B

ENSEMBL Gene Tree for PPP2R1B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PPP2R1B gene

PPP2R1A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/193 NCBI SNPs in PPP2R1B are shown (see all 193 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 72)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs647080^1,2	A,C,F,H,O	111114384(+)	`ACAAAA/GGAACA`	2	--	int¹ ut3¹		26		NS EU EA WA NA	1982
	rs2850247^1,2	C,F	111142412(+)	`AGCCGC/AGTTTC`	2	--	ng3¹		1		EA	1464
	rs11213993^1,2	F,H	111117253(+)	`GGAGCC/GCAGGT`	2	--	int¹ ut3¹ ese³		4		EU EA WA	418
	rs612345^1,2	A,C	111144332(+)	`GCTGTA/GTAAGA`	2	--	ng3¹ tfbs³		0	--	--	--	--
	rs12270084^1,2	F,H	111116047(+)	`CAAAAG/AGGTAA`	2	--	ut3¹ int¹		4		EU EA WA	414
	rs599764^1,2	H	111143773(+)	`GTAATG/TAAAGT`	2	--	ng3¹ tfbs³		1		EU	120
	rs619418^1,2	H	111115196(+)	`cagacA/Caaaat`	2	--	int¹ ut3¹		5		MN EU EA WA	598
--	rs45568137^1,2	F	111113468(+)	`CTTCAC/GAGGAA`	2	V/L	mis¹ ng5¹		1		NS	38
--	rs3216101^1,2	C	111115292(+)	`AAAAA-/ATAGGA`	2	--	ut3¹ int¹ trp³		0	--	--	--	--
	rs736650^1,2	A,C,F,H,O	111112261(-)	`TATGAC/TCCGAT`	1	--	int¹		8		EU EA WA NA NS	588

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HapMap Linkage Disequilibrium images for PPP2R1B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 603113 disorders: 211980

UniProtKB/Swiss-Prot: 2AAB_HUMAN, P30154

Defects in PPP2R1B might be a cause of some lung and colorectal cancers

10/15 Novoseek disease relationships for PPP2R1B gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
allelic loss	58.00	1	10935485 (1)
somatic mutations	56.83	2	10935485 (1), 15672406 (1)
paraganglioma	50.50	2	9795170 (1)
colon cancer	45.71	5	10597236 (1), 10896920 (1), 11342371 (1), 9765152 (1) (see all 5)
ovarian cancer	39.34	6	10597236 (4), 10935485 (1)
colorectal cancer	37.71	7	14767517 (4), 10896920 (3)
cervical cancer	34.63	5	17343570 (3), 15672406 (1), 11118052 (1)
cancer lung	28.47	4	10597236 (1), 10935485 (1), 10337999 (1)
tumors	28.09	9	10597236 (2), 10935485 (2), 14767517 (2), 10942591 (1) (see all 6)
breast carcinoma	22.35	2	10713707 (1), 16276521 (1)

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Human Gene Mutation Database: PPP2R1B
Genetic Association Database: PPP2R1B
Human Genome Epidemiology Navigator: PPP2R1B (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/51 PubMed articles for PPP2R1B gene (see all 51 ):

Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. (PubMed id 9795170)^{1, 2, 3, 4} Baysal B.E....Richard C.W. (1998)
Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. (PubMed id 2159327)^{2, 3, 4} Hemmings B.A.... Stone S.R. (1990)
Absence of PPP2R1B gene alterations in primary ovarian cancers. (PubMed id 10597236)^{1, 3, 4} Campbell I.G. and Manolitsas T. (1999)
Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. (PubMed id 10896920)^{1, 3, 4} Takagi Y.... Saji S. (2000)
Alterations of the PPP2R1B gene in human lung and colon cancer. (PubMed id 9765152)^{1, 3, 4} Wang S.S....Evans G.A. (1998)
The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. (PubMed id 16276521)^{1, 3, 6} Esplin E.D....Evans G.A. (2006)
Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. (PubMed id 11996789)^{1, 3, 4} Hemmer S.... Joensuu H. (2002)
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. (PubMed id 11313745)^{1, 3, 4} Baysal B.E.... Devlin B. (2001)
Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PubMed id 12670497)^{3, 4} Lubert E.J. and Sarge K.D. (2003)
PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers. (PubMed id 14767517)^{1, 3} Tamaki M....Yamaguchi A. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5519	HGNC: 9303	AceView: PPP2R1B	Ensembl:ENSG00000137713	euGenes: HUgn5519
ECgene: PPP2R1B	H-InvDB: PPP2R1B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PPP2R1B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PPP2R1B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PPP2R1B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
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	Millipore Custom Antibody & Bulk Services
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Antibodies for PPP2R1B

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PPP2R1B Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for PPP2R1B

Summaries
for PPP2R1B

Genomic Location
for PPP2R1B

Proteins
for PPP2R1B

Protein Domains/
Families
for PPP2R1B

Gene Function
for PPP2R1B

Pathways & Interactions
for PPP2R1B

Drugs & Compounds
for PPP2R1B

Transcripts
for PPP2R1B

Expression
for PPP2R1B

Orthologs
for PPP2R1B

Paralogs
for PPP2R1B

SNPs/Variants
for PPP2R1B

Disorders & Mutations
for PPP2R1B

Medical News
for PPP2R1B

Publications
for PPP2R1B

Search for PPP2R1B

Genome Databases showing PPP2R1B

Other Databases showing PPP2R1B

Specialized Databases showing PPP2R1B

Licensable Technologies
for PPP2R1B

Services
for PPP2R1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PPP2R1B Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor PPP2R1B

Summariesfor PPP2R1B

Genomic Locationfor PPP2R1B

Proteinsfor PPP2R1B

Protein Domains/Familiesfor PPP2R1B

Gene Functionfor PPP2R1B

Pathways & Interactionsfor PPP2R1B

Drugs & Compoundsfor PPP2R1B

Transcriptsfor PPP2R1B

Expression for PPP2R1B

Orthologsfor PPP2R1B

Paralogsfor PPP2R1B

SNPs/Variantsfor PPP2R1B

Disorders & Mutationsfor PPP2R1B

Medical Newsfor PPP2R1B

Publicationsfor PPP2R1B

Search for PPP2R1B

Genome Databases showing PPP2R1B

Other Databases showing PPP2R1B

Specialized Databases showing PPP2R1B

Licensable Technologiesfor PPP2R1B

Servicesfor PPP2R1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PPP2R1B

Summaries
for PPP2R1B

Genomic Location
for PPP2R1B

Proteins
for PPP2R1B

Protein Domains/
Families
for PPP2R1B

Gene Function
for PPP2R1B

Pathways & Interactions
for PPP2R1B

Drugs & Compounds
for PPP2R1B

Transcripts
for PPP2R1B

Expression
for PPP2R1B

Orthologs
for PPP2R1B

Paralogs
for PPP2R1B

SNPs/Variants
for PPP2R1B

Disorders & Mutations
for PPP2R1B

Medical News
for PPP2R1B

Publications
for PPP2R1B

Licensable Technologies
for PPP2R1B

Services
for PPP2R1B