Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP2R1B Gene

Aliases for PPP2R1B Gene

  • Protein Phosphatase 2, Regulatory Subunit A, Beta 2 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Beta Isoform 2 3
  • Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Beta Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta Isoform 2
  • Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta 3
  • PP2A, Subunit A, PR65-Beta Isoform 3
  • PP2A, Subunit A, R1-Beta Isoform 3
  • PP2A Subunit A Isoform PR65-Beta 4
  • PP2A Subunit A Isoform R1-Beta 4
  • Protein Phosphatase 2A 2
  • Regulatory Subunit A 2
  • Beta Isoform 2
  • PP2A-A-Beta 2
  • PP2A-Abeta 3
  • PR65B 3

External Ids for PPP2R1B Gene

Summaries for PPP2R1B Gene

Entrez Gene Summary for PPP2R1B Gene

  • This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R1B Gene

PPP2R1B (Protein Phosphatase 2, Regulatory Subunit A, Beta) is a Protein Coding gene. Diseases associated with PPP2R1B include lung hilum cancer and lung cancer. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. An important paralog of this gene is PPP2R1A.

UniProtKB/Swiss-Prot for PPP2R1B Gene

  • The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit

Tocris Summary for PPP2R1B Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for PPP2R1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R1B Gene

Genomics for PPP2R1B Gene

Genomic Location for PPP2R1B Gene

Start:
111,725,304 bp from pter
End:
111,769,101 bp from pter
Size:
43,798 bases
Orientation:
Minus strand

Genomic View for PPP2R1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP2R1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R1B Gene

Regulatory Elements for PPP2R1B Gene

Proteins for PPP2R1B Gene

  • Protein details for PPP2R1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30154-2AAB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    Protein Accession:
    P30154
    Secondary Accessions:
    • A8MY67
    • B0YJ69
    • B4DGQ6
    • B4DK91
    • B4DWW5
    • F8W8G1
    • O75620
    • Q8NHV8

    Protein attributes for PPP2R1B Gene

    Size:
    601 amino acids
    Molecular mass:
    66214 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with SGOL1. Interacts with RAF1.
    SequenceCaution:
    • Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAG59103.1; Type=Frameshift; Positions=540; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP2R1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R1B Gene

Proteomics data for PPP2R1B Gene at MOPED

Post-translational modifications for PPP2R1B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46, Lys145, Lys175, Lys200, Lys214, Lys267, Lys284, Lys289, Lys428, Lys484, Lys539, Lys554, Lys558, and Lys573

No data available for DME Specific Peptides for PPP2R1B Gene

Domains for PPP2R1B Gene

Gene Families for PPP2R1B Gene

HGNC:
  • PPP2R :Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

Protein Domains for PPP2R1B Gene

UniProtKB/Swiss-Prot:

2AAB_HUMAN
Domain:
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure:
    • P30154
Family:
  • Belongs to the phosphatase 2A regulatory subunit A family.:
    • P30154
Similarity:
  • Contains 15 HEAT repeats.:
    • P30154
genes like me logo Genes that share domains with PPP2R1B: view

Function for PPP2R1B Gene

Molecular function for PPP2R1B Gene

GENATLAS Biochemistry: serine/threonine phosphatase 2 (formerly 2A),regulatory subunit A,beta isoform,65kDa,altered in human lung and colon carcinomas,see TSG11F,LOH11CR2A
UniProtKB/Swiss-Prot Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit

Gene Ontology (GO) - Molecular Function for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 16456541
genes like me logo Genes that share ontologies with PPP2R1B: view

Phenotypes for PPP2R1B Gene

GenomeRNAi human phenotypes for PPP2R1B:
genes like me logo Genes that share phenotypes with PPP2R1B: view

miRNA for PPP2R1B Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP2R1B Gene

Localization for PPP2R1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R1B Gene COMPARTMENTS Subcellular localization image for PPP2R1B gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045121 membrane raft IDA 21172653
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PPP2R1B: view

Pathways for PPP2R1B Gene

genes like me logo Genes that share pathways with PPP2R1B: view

Gene Ontology (GO) - Biological Process for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060561 apoptotic process involved in morphogenesis IMP 21172653
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP 21172653
genes like me logo Genes that share ontologies with PPP2R1B: view

Compounds for PPP2R1B Gene

(5) Tocris Compounds for PPP2R1B Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(3) Novoseek inferred chemical compound relationships for PPP2R1B Gene

Compound -log(P) Hits PubMed IDs
threonine 41.2 3
serine 33.9 4
aspartate 17.1 1
genes like me logo Genes that share compounds with PPP2R1B: view

Transcripts for PPP2R1B Gene

Unigene Clusters for PPP2R1B Gene

Protein phosphatase 2, regulatory subunit A, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for PPP2R1B Gene

GeneLoc Exon Structure for
PPP2R1B
ECgene alternative splicing isoforms for
PPP2R1B

Expression for PPP2R1B Gene

mRNA expression in normal human tissues for PPP2R1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP2R1B Gene

This gene is overexpressed in Liver (14.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R1B Gene

SOURCE GeneReport for Unigene cluster for PPP2R1B Gene Hs.584790

genes like me logo Genes that share expressions with PPP2R1B: view

Orthologs for PPP2R1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R1B 36
  • 99.75 (n)
  • 99.55 (a)
PPP2R1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R1B 36
  • 91.64 (n)
  • 93.93 (a)
PPP2R1B 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R1B 36
  • 91.91 (n)
  • 95.63 (a)
PPP2R1B 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r1b 36
  • 87.96 (n)
  • 92.95 (a)
Ppp2r1b 16
Ppp2r1b 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R1B 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R1B 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r1b 36
  • 88.89 (n)
  • 96.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia ppp2r1b-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfb 36
  • 76.97 (n)
  • 88.95 (a)
zebrafish
(Danio rerio)
Actinopterygii ppp2r1a 37
  • 88 (a)
OneToMany
ppp2r1b 36
  • 74.21 (n)
  • 88.6 (a)
ppp2r1b 37
  • 88 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pp2A-29B 37
  • 65 (a)
OneToMany
Pp2A-29B 38
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea paa-1 37
  • 61 (a)
OneToMany
F48E8.5 38
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPD3 37
  • 42 (a)
OneToMany
TPD3 39
soybean
(Glycine max)
eudicotyledons Gma.7498 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PP2AA3 36
  • 57.36 (n)
  • 56.89 (a)
corn
(Zea mays)
Liliopsida Zm.2099 36
rice
(Oryza sativa)
Liliopsida Os09g0249700 36
  • 58.26 (n)
  • 57.91 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8422 37
  • 67 (a)
OneToMany
Species with no ortholog for PPP2R1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R1B Gene

ENSEMBL:
Gene Tree for PPP2R1B (if available)
TreeFam:
Gene Tree for PPP2R1B (if available)

Paralogs for PPP2R1B Gene

Paralogs for PPP2R1B Gene

Selected SIMAP similar genes for PPP2R1B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP2R1B: view

Variants for PPP2R1B Gene

Sequence variations from dbSNP and Humsavar for PPP2R1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14778 -- 111,741,547(-) AATTT(A/C)TAGTC utr-variant-3-prime, intron-variant
rs15503 -- 111,741,103(-) TGAAA(A/G)CCACA utr-variant-3-prime, intron-variant
rs523612 -- 111,730,669(-) CACAT(G/T)GGAGC intron-variant
rs524703 -- 111,731,596(-) GGGCT(C/T)AATTG intron-variant
rs533612 -- 111,726,718(-) TGTTT(C/T)GTTTG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPP2R1B Gene

Variant ID Type Subtype PubMed ID
nsv832269 CNV Loss 17160897

Relevant External Links for PPP2R1B Gene

HapMap Linkage Disequilibrium report
PPP2R1B
Human Gene Mutation Database (HGMD)
PPP2R1B

Disorders for PPP2R1B Gene

(1) OMIM Diseases for PPP2R1B Gene (603113)

(15) Novoseek inferred disease relationships for PPP2R1B Gene

Disease -log(P) Hits PubMed IDs
allelic loss 57.8 1
somatic mutations 56.1 2
paraganglioma 49.2 1
colon cancer 44.5 5
ovarian cancer 38.1 5

Relevant External Links for PPP2R1B

Genetic Association Database (GAD)
PPP2R1B
Human Genome Epidemiology (HuGE) Navigator
PPP2R1B
genes like me logo Genes that share disorders with PPP2R1B: view

No data available for UniProtKB/Swiss-Prot for PPP2R1B Gene

Publications for PPP2R1B Gene

  1. Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. (PMID: 9795170) Baysal B.E. … Richard C.W. III (Gene 1998) 2 3 4 23
  2. Absence of PPP2R1B gene alterations in primary ovarian cancers. (PMID: 10597236) Campbell I.G. … Manolitsas T. (Oncogene 1999) 3 4 23
  3. Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. (PMID: 10896920) Takagi Y. … Saji S. (Gut 2000) 3 4 23
  4. A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. (PMID: 11313745) Baysal B.E. … Devlin B. (Eur. J. Hum. Genet. 2001) 3 4 23
  5. Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. (PMID: 11996789) Hemmer S. … Joensuu H. (Cancer Genet. Cytogenet. 2002) 3 4 23

Products for PPP2R1B Gene

Sources for PPP2R1B Gene

Back to Top

Content