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PPP2R1A Gene

protein-coding   GIFtS: 68
GCID: GC19P052693

Protein Phosphatase 2, Regulatory Subunit A, Alpha

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Regulatory Subunit A, Alpha1 2     Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Alpha Isoform1
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Alpha
Isoform1 2
     Protein Phosphatase 2A1
Medium Tumor Antigen-Associated 61 KDa Protein2 3     Regulatory Subunit A1
PP2A Subunit A Isoform PR65-Alpha2 3     PP2A-Aalpha2
PP2A Subunit A Isoform R1-Alpha2 3     PP2AAALPHA2
65kDa Regulatory Subunit A1     PR65A2
Alpha Isoform1     Serine/Threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A,
Alpha Isoform2
Protein Phosphatase 21     Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Alpha
Isoform2

External Ids:    HGNC: 93021   Entrez Gene: 55182   Ensembl: ENSG000001055687   OMIM: 6059835   UniProtKB: P301533   

Export aliases for PPP2R1A gene to outside databases

Previous GC identifers: GC19P053323 GC19P053054 GC19P057370 GC19P057385 GC19P049024


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2R1A Gene:
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four
major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists
of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit,
that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding
molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene
encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have
been described. (provided by RefSeq, Apr 2010)

GeneCards Summary for PPP2R1A Gene:
PPP2R1A (protein phosphatase 2, regulatory subunit A, alpha) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein heterodimerization activity. An important paralog of this gene is PPP2R1B.

UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153
Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly
of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for
centromeric localization of SGOL1 in mitosis

summary for PPP2R1A Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2R1A gene promoter:
         NF-YA   CBF-C   GATA-1   AREB6   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP2R1A promoter sequence
   Search Chromatin IP Primers for PPP2R1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2R1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13

PPP2R1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R1A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052693:  view genomic region     (about GC identifiers)

Start:
52,693,055 bp from pter      End:
52,730,687 bp from pter
Size:
37,633 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform  
Size: 589 amino acids; 65309 Da
Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with FOXO1;
the interaction dephosphorylates FOXO1 on AKT-mediated phosphoylation sites (By similarity). PP2A consists of a
common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa
constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins
that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,
R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell
signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction
might decrease PP2A activity. Interacts with CTTNBP2NL
Selected PDB 3D structures from and Proteopedia for PPP2R1A (see all 14):
1B3U (3D)        2IE3 (3D)        2IE4 (3D)        2NPP (3D)        2NYL (3D)        2NYM (3D)    
Secondary accessions: Q13773 Q6ICQ3 Q96DH3

Explore the universe of human proteins at neXtProt for PPP2R1A: NX_P30153

Explore proteomics data for PPP2R1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34, Lys133, Lys163, Lys188, Lys194, Lys255, Lys266, Lys272, Lys280, Lys307,
                                 Lys416, Lys472, Lys475, Lys485, Lys519, Lys542, Lys546, Lys561
  • Modification sites at PhosphoSitePlus

  • See PPP2R1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055040.2  
    ENSEMBL proteins: 
     ENSP00000324804   ENSP00000469150   ENSP00000391905   ENSP00000471298   ENSP00000470504  
     ENSP00000375668   ENSP00000415067  
    Reactome Protein details: P30153

    PPP2R1A Human Recombinant Protein Products:

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    Novus Biologicals PPP2R1A Protein
    Novus Biologicals PPP2R1A Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for PPP2R1A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR000357 HEAT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P30153

    ProtoNet protein and cluster: P30153

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153
    Domain: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat
    loop. The repeat units may be arranged laterally to form a rod-like structure
    Similarity: Belongs to the phosphatase 2A regulatory subunit A family
    Similarity: Contains 15 HEAT repeats


    Find genes that share domains with PPP2R1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2AAA_HUMAN, P30153
    Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly
    of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for
    centromeric localization of SGOL1 in mitosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IPI9847399
    GO:0004722protein serine/threonine phosphatase activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI11504734
    GO:0008601protein phosphatase type 2A regulator activity TAS11007961
         
    Find genes that share ontologies with PPP2R1A           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PPP2R1A:
     Decreased G3BP1 protein expres  Decreased focal adhesion (FA)   Increased apoptosis  Increased cell death in HCT116 
     Increased mitotic exit time 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ppp2r1a):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  normal 
     tumorigenesis 

    Find genes that share phenotypes with PPP2R1A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPP2R1A
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    miRNA
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    miRTarBase miRNAs that target PPP2R1A:
    hsa-mir-106a-5p (MIRT048343), hsa-mir-941 (MIRT036561), hsa-mir-16-5p (MIRT031709), hsa-mir-20a-5p (MIRT050575), hsa-mir-222-3p (MIRT046765), hsa-mir-505-5p (MIRT037954), hsa-let-7e-5p (MIRT051517), hsa-mir-17-5p (MIRT050961), hsa-mir-92a-3p (MIRT049765)

    Block miRNA regulation of human, mouse, rat PPP2R1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2R1A (see all 27):
    hsa-miR-15a hsa-miR-4305 hsa-miR-885-5p hsa-miR-3138 hsa-miR-3684 hsa-miR-877* hsa-miR-424 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R1A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPP2R1A

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    Addgene plasmids for PPP2R1A 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    2AAA_HUMAN, P30153: Cytoplasm (By similarity). Chromosome, centromere. Note=Centromeric localization requires
    the presence of BUB1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    mitochondrion5
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex TAS11007961
    GO:0000775chromosome, centromeric region IDA16580887
    GO:0005634nucleus NAS11007961
    GO:0005739mitochondrion NAS11007961
    GO:0005829cytosol TAS11007961

    Find genes that share ontologies with PPP2R1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2R1A About   (see all 66)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    ERKs are inactivated0.00
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    Cell Cycle Control by BTG Proteins0.36
    Cyclin D associated events in G10.31
    3CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    CTLA4 inhibitory signaling0.32
    4Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    DARPP-32 events0.32
    5Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86


    Find genes that share SuperPaths with PPP2R1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2R1A (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    3 Cell Signaling Technology (CST) Pathways for PPP2R1A
        Phosphatases
    MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for PPP2R1A
        Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PPP2R1A (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway
    PLK1 signaling events
    Canonical Wnt signaling pathway


    Selected Reactome Pathways for PPP2R1A (see all 25)
        Initiation of Nuclear Envelope Reformation
    Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Recruitment of mitotic centrosome proteins and complexes
    ERKs are inactivated


    Selected Kegg Pathways  (Kegg details for PPP2R1A) (see all 11):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2R1A: 
              Telomeres & Telomerase in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP2R1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2R1A (P301531, 2, 3 ENSP000003248044) via UniProtKB, MINT, STRING, and/or I2D (see all 1262)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000188inactivation of MAPK activity NAS11007961
    GO:0000278mitotic cell cycle TAS--
    GO:0006275regulation of DNA replication NAS11007961

    Find genes that share ontologies with PPP2R1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for PPP2R1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    2 DrugBank Compounds for PPP2R1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-- --target--10592235
    2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP2R1A gene: 
    NM_014225.5  

    Unigene Cluster for PPP2R1A:

    Protein phosphatase 2, regulatory subunit A, alpha
    Hs.467192  [show with all ESTs]
    Unigene Representative Sequence: AK090488
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322088(uc002pyp.3 uc010ydk.2 uc010epm.1) ENST00000490868
    ENST00000454220 ENST00000477989 ENST00000468280 ENST00000462990(uc002pyq.3)
    ENST00000495876 ENST00000473455 ENST00000462047 ENST00000473820 ENST00000391791
    ENST00000444322
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    hsa-miR-15a hsa-miR-4305 hsa-miR-885-5p hsa-miR-3138 hsa-miR-3684 hsa-miR-877* hsa-miR-424 hsa-miR-661
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      QuantiTect SYBR Green Assays in human, mouse, rat PPP2R1A
      QuantiFast Probe-based Assays in human, mouse, rat PPP2R1A

    Additional mRNA sequence: 

    AK090488.1 AK091387.1 AK130000.1 AK290593.1 AK291932.1 AK293174.1 AK293493.1 AK299012.1 
    AK303934.1 AK307743.1 AK315700.1 BC001537.2 BC026733.1 CR450340.1 NR_033500.1 

    Selected DOTS entries (see all 59):

    DT.100045135  DT.92029602  DT.100867322  DT.121501411  DT.451403  DT.100867339  DT.100867327  DT.121501390 
    DT.95331984  DT.121501313  DT.121501346  DT.91873280  DT.95287869  DT.91775325  DT.95287599  DT.100867335 
    DT.121501293  DT.121501320  DT.92050216  DT.121501341  DT.121501414  DT.100867316  DT.100867342  DT.121501317 

    Selected AceView cDNA sequences (see all 1108):

    AA349572 BU146315 BM705077 BM018427 BP372087 BE267695 BM838587 AL549029 
    AU124904 BM836976 CB152782 BG056754 BP344119 AA379052 BC001537 AU105943 
    BU541632 BI772116 BM913572 CR604449 BF128729 BM905313 BM836459 BQ217180 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1A (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:                                                              -                                                                 -                           
    SP2:                          -     -     -     -     -     -     -                                                                 -                           
    SP3:                          -     -     -     -     -     -     -                                   -     -                       -                           
    SP4:                          -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -                           
    SP5:                                                                                                                                                            

    ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PPP2R1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPP2R1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGACCCC
    PPP2R1A Expression
    About this image


    PPP2R1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    PPP2R1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2R1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467192
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2R1A: 
              Telomeres & Telomerase in human mouse rat
              Apoptosis 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R1A gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r1a1 , 5 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform less5
    protein phosphatase 2, regulatory subunit A, alpha1
    90.55(n)1
    99.83(a)1
      17 (11.40 cM)5
    517921  NM_016891.31  NP_058587.11 
     209453115 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R1A6
    protein phosphatase 2, regulatory subunit A, alpha...
    93(a)
    1 ↔ 1
    GL343281.1(1620882-1642546)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046723.12   -- 80.56(n)    BC046723.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC046055.12   -- 80.71(n)    BC046055.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pp2A-29B1 , 3 protein amino acid dephosphorylation
    protein phosphatase type 2A, regulator less3
    Protein phosphatase 2A at 29B1
    75(a)3
    69.1(n)1
    74.7(a)1
      29B23
    27689401  NM_001032054.21  NP_001027225.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F48E8.53
    paa-11
    Protein phosphatase 2A3
    paa-11
    62(a)3
    58.88(n)1
    62.89(a)1
      III(5521881-5524543)3
    1757501  NM_065761.41  NP_498162.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPD31 TPD3 49.22(n)
    45.75(a)
      851217   NP_009386.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RCN11 RCN1 56.27(n)
    59.76(a)
      839135  NM_102360.3  NP_173920.1 
    rice
    (Oryza sativa)
    Liliopsida Os.13082 Oryza sativa mRNA for protein phosphatase 2A regulatory A subunit (RPA1 gene) less 70.1(n)    AJ243828.1 


    ENSEMBL Gene Tree for PPP2R1A (if available)
    TreeFam Gene Tree for PPP2R1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2R1A gene
    PPP2R1B2  
    16 SIMAP similar genes for PPP2R1A using alignment to 8 protein entries:     2AAA_HUMAN (see all proteins):
    PCTP    PPP2R1B    KIAA1651    OK/SW-cl.41    ZNF701    LRRC37A3
    FAM138C    ZNF573    ZNF843    APCDD1    C11orf58    PLA2G15
    ZNF195    ARL13B    CCT3    ZNF670

    Find genes that share paralogs with PPP2R1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PPP2R1A (see all 1022)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459136321,2
    C--52691154(+) GCTGGG/TACTGA 2 -- us2k10--------
    rs1181161331,2
    C,F--52691295(+) TGGGCG/AGATCA 2 -- us2k11Minor allele frequency- A:0.04EA 120
    rs794064801,2
    C--52691318(+) AGTTCG/AAGACC 2 -- us2k14Minor allele frequency- A:0.13NA WA EA 360
    rs1828184291,2
    --52691331(+) AGACAA/GCCAAC 2 -- us2k10--------
    rs1122277101,2
    C,F--52691380(+) CCGGGG/CGTGGT 2 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1910519391,2
    --52691381(+) CGGGCC/GTGGTG 2 -- us2k10--------
    rs1824010311,2
    --52691615(+) TGAGAC/GCAGCC 2 -- us2k10--------
    rs1134382721,2
    C--52691813(+) GTCTCA/-AAAAA 2 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1384726771,2
    C--52691860(+) GATGCC/TGTGGG 2 -- us2k10--------
    rs1891257811,2
    C--52691994(+) CGGTGG/TGGGGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP2R1A (52693055 - 52730687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPP2R1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518533CNV Loss19592680
    esv22131CNV Loss19812545

    Human Gene Mutation Database (HGMD): PPP2R1A
    Selected Site Specific Mutation Identification with PCR Assays for PPP2R1A (see all 10):
    Cosmic IdAA Change
    86035p.S256Y
    86038p.P179L
    76040p.W257C
    51211p.R183W
    86039p.S256F
    SeqTarget long-range PCR primers for resequencing PPP2R1A
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605983    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PPP2R1A:
    Serous cystadenocarcinoma

    Find genes that share disorders with PPP2R1A           About GenesLikeMe

    Genetic Association Database (GAD): PPP2R1A
    Human Genome Epidemiology (HuGE) Navigator: PPP2R1A (2 documents)

    Export disorders for PPP2R1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2R1A gene, integrated from 10 sources (see all 135):
    (articles sorted by number of sources associating them with PPP2R1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PubMed id 19890961)1, 4 Dupont W.D....Smith J.R. (Cancer 2010)
    2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1, 2 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    3. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)1, 2 Li H.H.... Liu X. (EMBO J. 2007)
    4. Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells. (PubMed id 17374643)1, 2 Nazarenko I.... Sers C. (J. Cell Sci. 2007)
    5. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (PubMed id 16580887)1, 2 Tang Z.... Yu H. (Dev. Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PubMed id 12670497)1, 2 Lubert E.J. and Sarge K.D. (Biochem. Biophys. Res. Commun. 2003)
    8. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. (PubMed id 9989501)1, 2 Groves M.R.... Barford D. (Cell 1999)
    9. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PubMed id 8694763)1, 2 Zolnierowicz S.... Hemmings B.A. (Biochem. J. 1996)
    10. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. (PubMed id 8254721)1, 2 Ruediger R.... Walter G. (J. Virol. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5518 HGNC: 9302 AceView: PPP2R1A Ensembl:ENSG00000105568 euGenes: HUgn5518
    ECgene: PPP2R1A Kegg: 5518 H-InvDB: PPP2R1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP2R1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP2R1A gene:
    Search GeneIP for patents involving PPP2R1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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