Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP2R1A Gene

Aliases for PPP2R1A Gene

  • Protein Phosphatase 2 Regulatory Subunit A, Alpha 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Alpha Isoform 2 3
  • Protein Phosphatase 2, Regulatory Subunit A, Alpha 2 3
  • PP2A Subunit A Isoform PR65-Alpha 3 4
  • PP2A Subunit A Isoform R1-Alpha 3 4
  • Serine/Threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Alpha Isoform 2
  • Medium Tumor Antigen-Associated 61 KDA Protein 3
  • Medium Tumor Antigen-Associated 61 KDa Protein 4
  • Testicular Secretory Protein Li 1 3
  • 65kDa Regulatory Subunit A 2
  • Protein Phosphatase 2A 2
  • Protein Phosphatase 2 2
  • Regulatory Subunit A 2
  • Alpha Isoform 2
  • PP2A-Aalpha 3
  • PP2AAALPHA 3
  • MRD36 3
  • PR65A 3

External Ids for PPP2R1A Gene

Previous GeneCards Identifiers for PPP2R1A Gene

  • GC19P053323
  • GC19P053054
  • GC19P057370
  • GC19P057385
  • GC19P052693
  • GC19P049024

Summaries for PPP2R1A Gene

Entrez Gene Summary for PPP2R1A Gene

  • This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R1A Gene

PPP2R1A (Protein Phosphatase 2 Regulatory Subunit A, Alpha) is a Protein Coding gene. Diseases associated with PPP2R1A include mental retardation, autosomal dominant 36 and endometrioid ovary carcinoma. Among its related pathways are Platelet activation, signaling and aggregation and Gene Expression. GO annotations related to this gene include protein heterodimerization activity and antigen binding. An important paralog of this gene is PPP2R1B.

UniProtKB/Swiss-Prot for PPP2R1A Gene

  • The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.

Tocris Summary for PPP2R1A Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R1A Gene

Genomics for PPP2R1A Gene

Regulatory Elements for PPP2R1A Gene

Promoters for PPP2R1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP2R1A on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2R1A Gene

Chromosome:
19
Start:
52,189,802 bp from pter
End:
52,229,533 bp from pter
Size:
39,732 bases
Orientation:
Plus strand

Genomic View for PPP2R1A Gene

Genes around PPP2R1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R1A Gene

Proteins for PPP2R1A Gene

  • Protein details for PPP2R1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30153-2AAA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Protein Accession:
    P30153
    Secondary Accessions:
    • Q13773
    • Q6ICQ3
    • Q96DH3

    Protein attributes for PPP2R1A Gene

    Size:
    589 amino acids
    Molecular mass:
    65309 Da
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphoylation sites (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction might decrease PP2A activity. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for PPP2R1A Gene

neXtProt entry for PPP2R1A Gene

Proteomics data for PPP2R1A Gene at MOPED

Post-translational modifications for PPP2R1A Gene

  • Ubiquitination at Lys 133, Lys 163, Lys 194, Lys 266, Lys 272, Lys 280, Lys 307, Lys 472, Lys 475, Lys 485, Lys 519, Lys 546, and Lys 561
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2R1A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP2R1A (PPP2R1A)

No data available for DME Specific Peptides for PPP2R1A Gene

Domains & Families for PPP2R1A Gene

Gene Families for PPP2R1A Gene

Protein Domains for PPP2R1A Gene

Graphical View of Domain Structure for InterPro Entry

P30153

UniProtKB/Swiss-Prot:

2AAA_HUMAN :
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
  • Belongs to the phosphatase 2A regulatory subunit A family.
  • Contains 15 HEAT repeats.
Domain:
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
Family:
  • Belongs to the phosphatase 2A regulatory subunit A family.
Similarity:
  • Contains 15 HEAT repeats.
genes like me logo Genes that share domains with PPP2R1A: view

Function for PPP2R1A Gene

Molecular function for PPP2R1A Gene

UniProtKB/Swiss-Prot Function:
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
genes like me logo Genes that share phenotypes with PPP2R1A: view

Human Phenotype Ontology for PPP2R1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPP2R1A Gene

MGI Knock Outs for PPP2R1A:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for PPP2R1A Gene

Localization for PPP2R1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R1A Gene

Cytoplasm. Chromosome, centromere. Note=Centromeric localization requires the presence of BUB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2R1A Gene COMPARTMENTS Subcellular localization image for PPP2R1A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PPP2R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IEA,TAS 11007961
genes like me logo Genes that share ontologies with PPP2R1A: view

Pathways & Interactions for PPP2R1A Gene

SuperPathways for PPP2R1A Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 MyD88 cascade initiated on plasma membrane
3 S45 mutants of beta-catenin arent phosphorylated
4 PI3K events in ERBB4 signaling
5 Regulation of PLK1 Activity at G2/M Transition
genes like me logo Genes that share pathways with PPP2R1A: view

SIGNOR curated interactions for PPP2R1A Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PPP2R1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000188 inactivation of MAPK activity NAS 11007961
GO:0000278 mitotic cell cycle TAS --
GO:0006355 regulation of transcription, DNA-templated NAS 11007961
GO:0006915 apoptotic process TAS 11007961
genes like me logo Genes that share ontologies with PPP2R1A: view

Drugs & Compounds for PPP2R1A Gene

(5) Drugs for PPP2R1A Gene - From: Tocris and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid Experimental Pharma Target 0
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Experimental Pharma Target 0
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPP2R1A Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ceramide
3102-57-6
DL-AP3
20263-06-3

(5) Tocris Compounds for PPP2R1A Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
genes like me logo Genes that share compounds with PPP2R1A: view

Transcripts for PPP2R1A Gene

Unigene Clusters for PPP2R1A Gene

Protein phosphatase 2, regulatory subunit A, alpha:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - - - - - -
SP11:
SP12: -
SP13: -

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP2R1A Gene

GeneLoc Exon Structure for
PPP2R1A
ECgene alternative splicing isoforms for
PPP2R1A

Expression for PPP2R1A Gene

mRNA expression in normal human tissues for PPP2R1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R1A Gene

This gene is overexpressed in Bone (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2R1A Gene



SOURCE GeneReport for Unigene cluster for PPP2R1A Gene Hs.467192

genes like me logo Genes that share expression patterns with PPP2R1A: view

Protein tissue co-expression partners for PPP2R1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP2R1A Gene

Orthologs for PPP2R1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2R1A 35
  • 92.76 (n)
  • 99.32 (a)
PPP2R1A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC484335 35
  • 92.08 (n)
  • 99.83 (a)
PPP2R1A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r1a 35
  • 90.55 (n)
  • 99.83 (a)
Ppp2r1a 16
Ppp2r1a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2R1A 35
  • 99.83 (n)
  • 100 (a)
PPP2R1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r1a 35
  • 90.78 (n)
  • 99.83 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP2R1A 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R1A 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R1A 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r1a 35
  • 80.08 (n)
  • 96.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pp2A-29B 37
  • 75 (a)
Pp2A-29B 35
  • 69.1 (n)
  • 74.7 (a)
Pp2A-29B 36
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009105 35
  • 71.18 (n)
  • 72.12 (a)
worm
(Caenorhabditis elegans)
Secernentea F48E8.5 37
  • 62 (a)
paa-1 35
  • 58.88 (n)
  • 62.89 (a)
paa-1 36
  • 62 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR279C 35
  • 51.22 (n)
  • 47.39 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07689g 35
  • 48.38 (n)
  • 45.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPD3 35
  • 49.22 (n)
  • 45.75 (a)
TPD3 36
  • 41 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RCN1 35
  • 56.27 (n)
  • 59.76 (a)
soybean
(Glycine max)
eudicotyledons Gma.6495 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6713 35
barley
(Hordeum vulgare)
Liliopsida Hv.1113 35
rice
(Oryza sativa)
Liliopsida Os.1308 35
wheat
(Triticum aestivum)
Liliopsida Ta.1998 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1500 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00488 35
  • 59.53 (n)
  • 56.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes paa1 35
  • 52.39 (n)
  • 53.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8422 36
  • 69 (a)
OneToMany
Species with no ortholog for PPP2R1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • zebrafish (Danio rerio)

Evolution for PPP2R1A Gene

ENSEMBL:
Gene Tree for PPP2R1A (if available)
TreeFam:
Gene Tree for PPP2R1A (if available)

Paralogs for PPP2R1A Gene

Paralogs for PPP2R1A Gene

genes like me logo Genes that share paralogs with PPP2R1A: view

Variants for PPP2R1A Gene

Sequence variations from dbSNP and Humsavar for PPP2R1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_073718 Mental retardation, autosomal dominant 36 (MRD36)
VAR_074488 Mental retardation, autosomal dominant 36 (MRD36)
VAR_074489 Mental retardation, autosomal dominant 36 (MRD36)
VAR_074490 Mental retardation, autosomal dominant 36 (MRD36)
rs755531 -- 52,215,937(-) CCCCT(C/T)GGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R1A Gene

Variant ID Type Subtype PubMed ID
esv22131 CNV Loss 19812545
nsv518533 CNV Loss 19592680

Variation tolerance for PPP2R1A Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2R1A Gene

HapMap Linkage Disequilibrium report
PPP2R1A
Human Gene Mutation Database (HGMD)
PPP2R1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R1A Gene

Disorders for PPP2R1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPP2R1A Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 36
  • mrd36
endometrioid ovary carcinoma
  • endometrioid carcinoma of ovary
hereditary wilms' tumor
  • nephroblastoma
ovarian clear cell carcinoma
  • clear-cell ovarian carcinoma
adenosarcoma
  • mullerian adenosarcoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

2AAA_HUMAN
  • Mental retardation, autosomal dominant 36 (MRD36) [MIM:616362]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:25533962, ECO:0000269 PubMed:26168268}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PPP2R1A

Genetic Association Database (GAD)
PPP2R1A
Human Genome Epidemiology (HuGE) Navigator
PPP2R1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2R1A
genes like me logo Genes that share disorders with PPP2R1A: view

No data available for Genatlas for PPP2R1A Gene

Publications for PPP2R1A Gene

  1. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PMID: 19890961) Dupont W.D. … Smith J.R. (Cancer 2010) 3 48 67
  2. An LRP16-containing preassembly complex contributes to NF-I_B activation induced by DNA double-strand breaks. (PMID: 25735744) Wu Z. … Han W. (Nucleic Acids Res. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PPP2R1A Gene

Sources for PPP2R1A Gene

Back to Top

Content