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PPP2R1A Gene

protein-coding GIFtS: 65

GC19P057385

protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC786 ^²
PR65A ^¹, ²

Descriptions
Medium tumor antigen-associated 61 kDa protein ^², ³
PP2A, subunit A, PR65-alpha isoform ^², ³
PP2A, subunit A, R1-alpha isoform ^², ³
alpha isoform of regulatory subunit A, protein phosphatase 2 ^²
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform ^¹, ²
protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform ^²
serine/threonine protein phosphatase 2A, 65 KDA regulatory subunit A, alpha isoform ^²

External Ids
HGNC: 9302¹
Entrez Gene: 5518²
UniProtKB: P30153³
Ensembl: ENSG00000105568⁷

Search outside databases for aliases for PPP2R1A gene

Previous GC identifers: GC19P053323 GC19P053054 GC19P057370

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PPP2R1A:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is

one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell

growth and division. It consists of a common heteromeric core enzyme, which is composed of a

catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory

subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the

assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha

isoform of the constant regulatory subunit A. [provided by RefSeq]

UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate

the assembly of the catalytic subunit and a variable regulatory B subunit

Gene Wiki entry for PPP2R1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PPP2R1A gene

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13

PPP2R1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P057385: (about GC identifiers)

Start:	57,385,046 bp from pter
End:	57,422,499 bp from pter
Size:	37,454 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Size: 589 amino acids; 65309 Da

Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic

subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates

with a variety of regulatory subunits. Proteins that associate with the core dimer include three

families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56

families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Interacts with IPO9

PDB structures from and Proteopedia :

1B3U (3D)

2IE3 (3D)

2IE4 (3D)

2NPP (3D)

2NYL (3D)

2NYM (3D)

2PKG (3D)

3C5W (3D)

3DW8 (3D)

Secondary accessions: Q13773 Q6ICQ3 Q96DH3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055040.2

ENSEMBL proteins:

ENSP00000324804 ENSP00000375668

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant PPP2R1A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PPP2R1A
	Recombinant Proteins from Abcam (PPP2R1A)
	Human Recombinant Proteins from Abnova (PPP2R1A)

OriGene Purified Recombinant Human Protein: PPP2R1A

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000159	protein phosphatase type 2A complex	TAS	11007961
GO:0005625	soluble fraction	NAS	11007961
GO:0005634	nucleus	NAS	11007961
GO:0005739	mitochondrion	NAS	11007961
GO:0005829	cytosol	TAS	11007961

About this table

Antibodies for PPP2R1A:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PPP2R1A
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PPP2R1A (PP 2A A Subunit)
	Antibodies from Abcam (PPP2R1A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PPP2R1A)
	Novus Biologicals Antibodies for PPP2R1A

Assays for PPP2R1A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P30153

ProtoNet protein and cluster: P30153

1 Blocks protein family: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153

Domain: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region,

the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure

Similarity: Belongs to the phosphatase 2A regulatory subunit A family

Similarity: Contains 15 HEAT repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PPP2R1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPP2R1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC001537

Applied Biosystems Silencer® siRNAs for PPP2R1A

Sigma-Aldrich siRNA and siRNA Panels for PPP2R1A

Sigma-Aldrich shRNA Panels and shRNA for PPP2R1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PPP2R1A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014225
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014225
untagged cDNA clones in CMV expression vector (see all 3): BC001537

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC001537

UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate

the assembly of the catalytic subunit and a variable regulatory B subunit

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003823	antigen binding	IPI	9847399
GO:0005515	protein binding	IPI	9847399
GO:0008601	protein phosphatase type 2A regulator activity	TAS	11007961
GO:0046982	protein heterodimerization activity	IPI	9847399

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/13 Sigma-Aldrich "Your Favorite Gene" Pathways for PPP2R1A (Your Favorite Gene powered by Ingenuity) (see all 13 )

CDK5 Signaling
Cardiac &beta
Wnt/&beta
Synaptic Long Term Depression
Dopamine Receptor Signaling

GeneDecks PPP2R1A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PPP2R1A

5/141 Interacting proteins for PPP2R1A (ENSP00000324804³ P30153^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 141 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2CA	P67775¹	STRING (score=.999) EBI-302388, EBI-712311
PPP4C	P60510¹	STRING (score=.791) EBI-302388, EBI-1046072
CFTR	P13569²	STRING (score=.826) MINT-62218 MINT-62222 MINT-62219 MINT-62221
AKT1	P31749²	STRING (score=.724) MINT-74932 MINT-74940
TP53	P04637²	STRING (score=.804) MINT-4299110 MINT-4299098

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5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000188	inactivation of MAPK activity	NAS	11007961
GO:0006275	regulation of DNA replication	NAS	11007961
GO:0006461	protein complex assembly	TAS	9989501
GO:0006470	protein amino acid dephosphorylation	TAS	11007961
GO:0006672	ceramide metabolic process	NAS	11007961

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PPP2R1A

Sigma-Aldrich Small Molecules for PPP2R1A:

Inhibitor

Compounds for PPP2R1A available from Tocris Bioscience

Compound	Action	CAS number
Cantharidin	Protein phosphatase 1 and 2A inhibitor	[56-25-7]
Okadaic acid	Protein phosphatase 1 and 2A inhibitor	[78111-17-8]
Calyculin A	Protein phosphatase 1 and 2A inhibitor	[101932-71-2]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PPP2R1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPP2R1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC001537

Sigma-Aldrich siRNA and siRNA Panels for PPP2R1A

Sigma-Aldrich shRNA Panels and shRNA for PPP2R1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014225

REFSEQ mRNAs for PPP2R1A gene:

NM_014225.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014225

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014225
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014225
                                 untagged cDNA clones in CMV expression vector (see all 3): BC001537

Additional cDNA sequence:

AK090488.1 AK091387.1 AK130000.1 AK290593.1 AK291932.1 AK293174.1 AK293493.1 AK299012.1

AK303934.1 AK307743.1 AK315700.1 BC001537.2 BC026733.1 CR450340.1 CR604449.1 CR623106.1

24/59 DOTS entries (see all 59 ):

DT.100045135 DT.92029602 DT.100867322 DT.121501411 DT.451403 DT.100867339 DT.100867327 DT.121501390

DT.95331984 DT.121501313 DT.121501346 DT.91873280 DT.95287869 DT.91775325 DT.95287599 DT.100867335

DT.121501293 DT.121501320 DT.92050216 DT.121501341 DT.121501414 DT.100867316 DT.100867342 DT.121501317

24/1108 AceView cDNA sequences (see all 1108 ):

AL540199 AL548052 BF525426 BE207521 AX746952 AW016703 AA371582 CB152782

BM018427 BQ052458 BU849070 BE885917 AU280013 BQ639115 CA488650 BM773326

AA025813 CF131359 BI768259 BQ717878 BM920678 BG389824 BF512610 BM560964

highest scoring ESTs for PPP2R1A:

AA025497 AA040666 AA046266 AA053465 AA074556 AA079527 AA132753 AA159030 AA159169 AA228713

Unigene Cluster for PPP2R1A:

Protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform

Hs.467192 [show with all ESTs]

Unigene Representative Sequence: AK090488

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1A (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11	^	12	^
SP1:																					-																						-
SP2:									-		-		-		-		-		-		-																						-
SP3:									-		-		-		-		-		-		-												-		-								-
SP4:									-		-		-		-		-		-		-								-		-		-		-		-		-		-		-
SP5:

ExUns:	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20a	·	20b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PPP2R1A

2 Ensembl transcripts including schematic representations:

ENST00000322088 ENST00000391791

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PPP2R1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PPP2R1A

¹ / ² / ³

4 probe-sets matching PPP2R1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
922_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.07	J02902	0.80	1.00	0.91	1
40867_at²^{, 3}	U95-A	1	1.00	1.00	1.00	0.93	J02902	0.80	1.00	0.91	1
200695_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014225	0.60	1.00	0.82	1
200695_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PPP2R1A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCTGACCCC

SOURCE GeneReport for Unigene cluster: Hs.467192
Expression variation in blood from EXPOLDB for PPP2R1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PPP2R1A gene from 5/24 species (see all 24 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PPP2R1A¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	92.08(n) 99.83(a)	484335 XM_845900.1 XP_850993.1
chimpanzee (Pan troglodytes)	PPP2R1A¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	99.83(n) 100(a)	468983 XM_001174546.1 XP_001174546.1
cow (Bos taurus)	PPP2R1A¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	92.76(n) 99.32(a)	535321 NM_001037477.1 NP_001032554.1
rat (Rattus norvegicus)	Ppp2r1a¹	--	protein phosphatase 2 (formerly 2A), regulatory subunit more	90.78(n) 99.83(a)	117281 NM_057140.1 NP_476481.1
mouse (Mus musculus)	Ppp2r1a^{1, 5}	17⁵	protein phosphatase 2 (formerly 2A), regulatory subunit more^{1, 5}	90.55(n)¹ 99.83(a)¹	51792¹ NM_016891.3¹ NP_058587.1¹ AA068956⁵ AB021743⁵ (see all 22)

About this table Species with no ortholog for PPP2R1A

ENSEMBL Gene Tree for PPP2R1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PPP2R1A gene

PPP2R1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/238 NCBI SNPs in PPP2R1A are shown (see all 238 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 116)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2162779^1,2	A,C,F,H	57421511(-)	`CTCCAA/TGCTGA`	1	--	ng3¹		5		EA EU WA	1898
	rs13344984^1,2	A,C,F,H	57385089(+)	`CTTCTT/CCTCCC`	1	--	ut5¹ trp³		4		EU EA WA	420
--	rs1864007^1,2	A,C,F,H	57384435(-)	`tggacC/Ttcccc`	1	--	ng5¹		1		WA	116
	rs10414852^1,2	A,F,H	57421610(+)	`AGAATA/TCTCTG`	1	--	ng3¹		4		EU EA WA	410
	rs10421004^1,2	A,F,H	57384640(+)	`CGCAAC/AGGCGC`	1	--	ng5¹		3		EU EA	266
	rs8107383^1,2	C,F,H	57384108(+)	`CAGAAG/ATGAAT`	1	--	ng5¹		4		EU EA WA	420
--	rs3833207^1,2	C	57385109(+)	`CCCCC-/CRCGTT`	1	--	ut5¹		0	--	--	--	--
--	rs11453459^1,2	F	57384761(+)	`TTCCC-/GGGGGA`	1	--	ng5¹		2		MN EA	356
	rs10413435^1,2	C,F,H	57420842(+)	`GTGGAC/TGTCAA`	1	D/D	syn¹ ese³		12		NA EU EA WA	1034
	rs11537695^1,2	C,F	57406531(+)	`GTGTCC/TAGTGC`	1	S/S	syn¹		1		NA	54

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HapMap Linkage Disequilibrium images for PPP2R1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605983

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/41 PubMed articles for PPP2R1A gene (see all 41 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PubMed id 12670497)^{3, 4} Lubert E.J. and Sarge K.D. (2003)
The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. (PubMed id 9989501)^{3, 4} Groves M.R.... Barford D. (1999)
The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PubMed id 8694763)^{3, 4} Zolnierowicz S.... Hemmings B.A. (1996)
Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. (PubMed id 8254721)^{3, 4} Ruediger R.... Walter G. (1994)
Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. (PubMed id 2159327)^{3, 4} Hemmings B.A.... Stone S.R. (1990)
Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein. (PubMed id 2554323)^{3, 4} Walter G.... Carbone-Wiley A. (1989)
A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)³ Goudreault M....Gingras A.C. (2009)
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. (PubMed id 18715871)³ Chen G.I.... Gingras A.C. (2008)
Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax. (PubMed id 17314097)³ Hong S....Giam C.Z. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5518	HGNC: 9302	AceView: PPP2R1A	Ensembl:ENSG00000105568	euGenes: HUgn5518
ECgene: PPP2R1A	H-InvDB: PPP2R1A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PPP2R1A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PPP2R1A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PPP2R1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PPP2R1A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PPP2R1A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PPP2R1A		Small molecules for PPP2R1A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PPP2R1A)
	Antibodies (PPP2R1A)
	Chimera RNAi (PPP2R1A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PPP2R1A (PP 2A A Subunit)

	Recombinant Proteins (PPP2R1A)
	Antibodies (PPP2R1A)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for PPP2R1A

	Drugs/Proteins for PPP2R1A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PPP2R1A

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PPP2R1A Gene at Home site.
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PPP2R1A Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for PPP2R1A

Summaries
for PPP2R1A

Genomic Location
for PPP2R1A

Proteins
for PPP2R1A

Protein Domains/
Families
for PPP2R1A

Gene Function
for PPP2R1A

Pathways & Interactions
for PPP2R1A

Drugs & Compounds
for PPP2R1A

Transcripts
for PPP2R1A

Expression
for PPP2R1A

Orthologs
for PPP2R1A

Paralogs
for PPP2R1A

SNPs/Variants
for PPP2R1A

Disorders & Mutations
for PPP2R1A

Medical News
for PPP2R1A

Publications
for PPP2R1A

Search for PPP2R1A

Genome Databases showing PPP2R1A

Other Databases showing PPP2R1A

Specialized Databases showing PPP2R1A

Licensable Technologies
for PPP2R1A

Services
for PPP2R1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PPP2R1A Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor PPP2R1A

Summariesfor PPP2R1A

Genomic Locationfor PPP2R1A

Proteinsfor PPP2R1A

Protein Domains/Familiesfor PPP2R1A

Gene Functionfor PPP2R1A

Pathways & Interactionsfor PPP2R1A

Drugs & Compoundsfor PPP2R1A

Transcriptsfor PPP2R1A

Expression for PPP2R1A

Orthologsfor PPP2R1A

Paralogsfor PPP2R1A

SNPs/Variantsfor PPP2R1A

Disorders & Mutationsfor PPP2R1A

Medical Newsfor PPP2R1A

Publicationsfor PPP2R1A

Search for PPP2R1A

Genome Databases showing PPP2R1A

Other Databases showing PPP2R1A

Specialized Databases showing PPP2R1A

Licensable Technologiesfor PPP2R1A

Servicesfor PPP2R1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PPP2R1A

Summaries
for PPP2R1A

Genomic Location
for PPP2R1A

Proteins
for PPP2R1A

Protein Domains/
Families
for PPP2R1A

Gene Function
for PPP2R1A

Pathways & Interactions
for PPP2R1A

Drugs & Compounds
for PPP2R1A

Transcripts
for PPP2R1A

Expression
for PPP2R1A

Orthologs
for PPP2R1A

Paralogs
for PPP2R1A

SNPs/Variants
for PPP2R1A

Disorders & Mutations
for PPP2R1A

Medical News
for PPP2R1A

Publications
for PPP2R1A

Licensable Technologies
for PPP2R1A

Services
for PPP2R1A