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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP2R1A Gene

protein-coding   GIFtS: 68
GCID: GC19P052693

Protein Phosphatase 2, Regulatory Subunit A, Alpha

(Previous names: protein phosphatase 2 (formerly 2A), regulatory subunit...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Phosphatase 2, Regulatory Subunit A, Alpha1 2     Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Alpha Isoform1
Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Alpha
Isoform1 2
     Protein Phosphatase 2A1
Medium Tumor Antigen-Associated 61 KDa Protein2 3     Regulatory Subunit A1
PP2A Subunit A Isoform PR65-Alpha2 3     PP2A-Aalpha2
PP2A Subunit A Isoform R1-Alpha2 3     PP2AAALPHA2
65kDa Regulatory Subunit A1     PR65A2
Alpha Isoform1     Serine/Threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A,
Alpha Isoform2
Protein Phosphatase 21     Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Alpha
Isoform2

External Ids:    HGNC: 93021   Entrez Gene: 55182   Ensembl: ENSG000001055687   OMIM: 6059835   UniProtKB: P301533   
ORGUL members:         
NONCODE14:n409289      

Export aliases for PPP2R1A gene to outside databases

Previous GC identifers: GC19P053323 GC19P053054 GC19P057370 GC19P057385 GC19P049024


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP2R1A Gene:
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four
major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists
of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit,
that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding
molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene
encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have
been described. (provided by RefSeq, Apr 2010)

GeneCards Summary for PPP2R1A Gene: 
PPP2R1A (protein phosphatase 2, regulatory subunit A, alpha) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PPP2R1A include ovarian brenner tumor, and serous cystadenocarcinoma, and among its related super-pathways are Cyclins and Cell Cycle Regulation and Costimulation by the CD28 family. GO annotations related to this gene include protein serine/threonine phosphatase activity and protein heterodimerization activity. An important paralog of this gene is PPP2R1B.

UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153
Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly
of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for
centromeric localization of SGOL1 in mitosis

summary for PPP2R1A Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2R1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP2R1A gene promoter:
         NF-YA   CBF-C   GATA-1   AREB6   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPP2R1A promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP2R1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2R1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13

PPP2R1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2R1A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052693:  view genomic region     (about GC identifiers)

Start:
52,693,055 bp from pter      End:
52,730,687 bp from pter
Size:
37,633 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform  
Size: 589 amino acids; 65309 Da
Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with FOXO1;
the interaction dephosphorylates FOXO1 on AKT-mediated phosphoylation sites (By similarity). PP2A consists of a
common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa
constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins
that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,
R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell
signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction
might decrease PP2A activity. Interacts with CTTNBP2NL
Subcellular location: Cytoplasm (By similarity). Chromosome, centromere. Note=Centromeric localization requires
the presence of BUB1
6/13 PDB 3D structures from and Proteopedia for PPP2R1A (see all 13):
1B3U (3D)        2IE3 (3D)        2IE4 (3D)        2NPP (3D)        2NYL (3D)        2NYM (3D)    
Secondary accessions: Q13773 Q6ICQ3 Q96DH3

Explore the universe of human proteins at neXtProt for PPP2R1A: NX_P30153

Explore proteomics data for PPP2R1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30153

  • PPP2R1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP2R1A Protein Expression
    REFSEQ proteins: NP_055040.2  
    ENSEMBL proteins: 
     ENSP00000324804   ENSP00000469150   ENSP00000391905   ENSP00000471298   ENSP00000470504  
     ENSP00000375668   ENSP00000415067  
    Reactome Protein details: P30153
    Human Recombinant Protein Products for PPP2R1A: 
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    Novus Biologicals PPP2R1A Protein
    Novus Biologicals PPP2R1A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex TAS11007961
    GO:0000775chromosome, centromeric region IDA16580887
    GO:0005634nucleus NAS11007961
    GO:0005739mitochondrion NAS11007961
    GO:0005829cytosol TAS11007961

    PPP2R1A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP2R: Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR000357 HEAT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P30153

    ProtoNet protein and cluster: P30153

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: 2AAA_HUMAN, P30153
    Domain: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat
    loop. The repeat units may be arranged laterally to form a rod-like structure
    Similarity: Belongs to the phosphatase 2A regulatory subunit A family
    Similarity: Contains 15 HEAT repeats


    PPP2R1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 2AAA_HUMAN, P30153
    Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly
    of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for
    centromeric localization of SGOL1 in mitosis

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IPI9847399
    GO:0004722protein serine/threonine phosphatase activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI11504734
    GO:0008601protein phosphatase type 2A regulator activity TAS11007961
         
    PPP2R1A for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PPP2R1A:
     Decreased G3BP1 protein expres  Decreased focal adhesion (FA)   Increased apoptosis  Increased cell death in HCT116 
     Increased mitotic exit time 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ppp2r1a):
     behavior/neurological  growth/size  homeostasis/metabolism  mortality/aging  normal 
     tumorigenesis 

    PPP2R1A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPP2R1A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPP2R1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPP2R1A 

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    hsa-miR-15a hsa-miR-4305 hsa-miR-885-5p hsa-miR-3138 hsa-miR-3684 hsa-miR-877* hsa-miR-424 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidPPP2R1A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP2R1A About   (see all 67)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    Cell Cycle Control by BTG Proteins0.36
    Cyclin D associated events in G10.32
    2CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    3TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    4ERK/MAPK targets
    ERK/MAPK targets0.88
    ERKs are inactivated0.57
    Nuclear Events (kinase and transcription factor activation)0.88
    PP2A-mediated dephosphorylation of key metabolic factors0.36
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    MASTL Facilitates Mitotic Progression0.31
    5Recruitment of mitotic centrosome proteins and complexes
    Centrosome maturation0.83
    Mitotic G2-G2/M phases0.81
    Recruitment of mitotic centrosome proteins and complexes0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    G2/M Transition0.83
    Loss of Nlp from mitotic centrosomes0.78

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PPP2R1A
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2R1A (see all 25)
        Cell Cycle Control by BTG Proteins
    Telomerase Components in Cell Signaling
    CDK5 Pathway
    mTOR Pathway
    Cyclins and Cell Cycle Regulation

    3 Cell Signaling Technology (CST) Pathways for PPP2R1A
        Phosphatases
    MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for PPP2R1A
        Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/6 BioSystems Pathways for PPP2R1A (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway
    PLK1 signaling events
    Canonical Wnt signaling pathway

    5/81        Reactome Pathways for PPP2R1A (see all 81)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Platelet homeostasis
    Recruitment of mitotic centrosome proteins and complexes
    Toll Like Receptor 3 (TLR3) Cascade


    5/10         Kegg Pathways  (Kegg details for PPP2R1A) (see all 10):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    TGF-beta signaling pathway
    Hippo signaling pathway


    PPP2R1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP2R1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1221 Interacting proteins for PPP2R1A (P301531, 2, 3 ENSP000003248044) via UniProtKB, MINT, STRING, and/or I2D (see all 1221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000188inactivation of MAPK activity NAS11007961
    GO:0000278mitotic cell cycle TAS--
    GO:0006275regulation of DNA replication NAS11007961

    PPP2R1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PPP2R1A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PPP2R1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    2 DrugBank Compounds for PPP2R1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-- --target--10592235
    2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about PPP2R1A / 2AAA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PPP2R1A gene: 
    NM_014225.5  

    Unigene Cluster for PPP2R1A:

    Protein phosphatase 2, regulatory subunit A, alpha
    Hs.467192  [show with all ESTs]
    Unigene Representative Sequence: AK090488
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322088(uc002pyp.3 uc010ydk.2 uc010epm.1) ENST00000490868
    ENST00000454220 ENST00000477989 ENST00000468280 ENST00000462990(uc002pyq.3)
    ENST00000495876 ENST00000473455 ENST00000462047 ENST00000473820 ENST00000391791
    ENST00000444322
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2R1A

    Additional mRNA sequence: 

    AK090488.1 AK091387.1 AK130000.1 AK290593.1 AK291932.1 AK293174.1 AK293493.1 AK299012.1 
    AK303934.1 AK307743.1 AK315700.1 BC001537.2 BC026733.1 CR450340.1 NR_033500.1 

    24/59 DOTS entries (see all 59):

    DT.100045135  DT.92029602  DT.100867322  DT.121501411  DT.451403  DT.100867339  DT.100867327  DT.121501390 
    DT.95331984  DT.121501313  DT.121501346  DT.91873280  DT.95287869  DT.91775325  DT.95287599  DT.100867335 
    DT.121501293  DT.121501320  DT.92050216  DT.121501341  DT.121501414  DT.100867316  DT.100867342  DT.121501317 

    24/1108 AceView cDNA sequences (see all 1108):

    BM663883 BU151368 CR604449 AU105943 BE267690 BU521250 CF131885 BM423452 
    BF128729 BP343551 BU556714 BQ639776 BM018427 BQ639115 BQ674945 AU141169 
    BM745013 AA345100 BU849904 CB152782 BM461921 AU124904 BM552085 BI768259 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1A (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:                                                              -                                                                 -                           
    SP2:                          -     -     -     -     -     -     -                                                                 -                           
    SP3:                          -     -     -     -     -     -     -                                   -     -                       -                           
    SP4:                          -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -                           
    SP5:                                                                                                                                                            

    ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PPP2R1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP2R1A expression in normal human tissues (normalized intensities)      PPP2R1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGACCCC
    PPP2R1A Expression
    About this image


    PPP2R1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   

    See PPP2R1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP2R1A

    SOURCE GeneReport for Unigene cluster: Hs.467192
        SABiosciences Expression via Pathway-Focused PCR Arrays including PPP2R1A: 
              Telomeres & Telomerase in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2R1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2R1A gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2r1a1 , 5 protein phosphatase 2 (formerly 2A), regulatory subunit more1, 5 90.55(n)1
    99.83(a)1
      17 (11.40 cM)5
    517921  NM_016891.31  NP_058587.11 
     209453115 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2R1A6
    protein phosphatase 2, regulatory subunit A, alpha...
    93(a)
    1 ↔ 1
    GL343281.1(1620882-1642546)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046723.12   -- 80.56(n)    BC046723.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC046055.12   -- 80.71(n)    BC046055.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pp2A-29B1 , 3 protein amino acid dephosphorylation
    protein phosphatase more3
    Protein phosphatase 2A at 29B1
    75(a)3
    69.1(n)1
    74.7(a)1
      29B23
    27689401  NM_001032056.21  NP_001027227.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F48E8.53
    paa-11
    Protein phosphatase 2A3
    Protein PAA-11
    62(a)3
    58.88(n)1
    62.89(a)1
      III(5521881-5524543)3
    1757501  NM_065761.31  NP_498162.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPD31 Tpd3p 49.34(n)
    45.75(a)
      851217   NP_009386.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PP2AA31 protein phosphatase 2A subunit A3 56.08(n)
    59.16(a)
      837892  NM_101203.4  NP_172790.2 
    rice
    (Oryza sativa)
    Liliopsida Os.13082 Oryza sativa mRNA for protein phosphatase 2A regulatory more 70.1(n)    AJ243828.1 


    ENSEMBL Gene Tree for PPP2R1A (if available)
    TreeFam Gene Tree for PPP2R1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP2R1A gene
    PPP2R1B2  
    18/20 SIMAP similar genes for PPP2R1A using alignment to 8 protein entries:     2AAA_HUMAN (see all proteins) (see all similar genes):
    PCTP    PPP2R1B    KIAA1651    OK/SW-cl.41    ZNF701    LRRC37A3
    FAM138A    FAM138B    FAM138C    FAM138F    ZNF573    ZNF843
    APCDD1    FAM138D    C11orf58    PLA2G15    ZNF195    ARL13B

    PPP2R1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1022 SNPs in PPP2R1A are shown (see all 1022)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459136321,2
    C--52691154(+) GCTGGG/TACTGA 2 -- us2k10--------
    rs1181161331,2
    C,F--52691295(+) TGGGCG/AGATCA 2 -- us2k11Minor allele frequency- A:0.04EA 120
    rs794064801,2
    C--52691318(+) AGTTCG/AAGACC 2 -- us2k14Minor allele frequency- A:0.13NA WA EA 360
    rs1828184291,2
    --52691331(+) AGACAA/GCCAAC 2 -- us2k10--------
    rs1122277101,2
    C,F--52691380(+) CCGGGG/CGTGGT 2 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1910519391,2
    --52691381(+) CGGGCC/GTGGTG 2 -- us2k10--------
    rs1824010311,2
    --52691615(+) TGAGAC/GCAGCC 2 -- us2k10--------
    rs1134382721,2
    C--52691813(+) GTCTCA/-AAAAA 2 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1384726771,2
    C--52691860(+) GATGCC/TGTGGG 2 -- us2k10--------
    rs1891257811,2
    C--52691994(+) CGGTGG/TGGGGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPP2R1A (52693055 - 52730687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPP2R1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518533CNV Loss19592680
    esv22131CNV Loss19812545


    Human Gene Mutation Database (HGMD): PPP2R1A
    5/10 SABiosciences Cancer Mutation PCR Assays for PPP2R1A (see all 10):
    Cosmic IdAA Change
    86035p.S256Y
    86038p.P179L
    76040p.W257C
    51211p.R183W
    86039p.S256F
    SeqTarget long-range PCR primers for resequencing PPP2R1A
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2R1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605983    OMIM disorders: --

    20/22 diseases for PPP2R1A (see all 22):    About MalaCards
    ovarian brenner tumor    serous cystadenocarcinoma    cerebral cavernous malformations 3    cavernous malformation
    cerebral cavernous malformation    cystadenocarcinoma    breast disease    trypanosomiasis
    chagas disease    ataxia telangiectasia    wilms tumor    cerebritis
    kaposi's sarcoma    ataxia    hepatitis    hepatitis c
    hepatitis b    sarcoma    hypoxia    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for PPP2R1A:
    Serous cystadenocarcinoma

    PPP2R1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PPP2R1A
    Human Genome Epidemiology (HuGE) Navigator: PPP2R1A (2 documents)

    Export disorders for PPP2R1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP2R1A gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with PPP2R1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein phosphatase 2A subunit gene haplotypes and pr oliferative breast disease modify breast cancer risk. (PubMed id 19890961)1, 4 Dupont W.D....Smith J.R. (2010)
    2. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1, 2 Goudreault M....Gingras A.C. (2009)
    3. Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells. (PubMed id 17374643)1, 2 Nazarenko I....Sers C. (2007)
    4. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)1, 2 Li H.H.... Liu X. (2007)
    5. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (PubMed id 16580887)1, 2 Tang Z....Yu H. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PubMed id 12670497)1, 2 Lubert E.J. and Sarge K.D. (2003)
    8. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. (PubMed id 9989501)1, 2 Groves M.R.... Barford D. (1999)
    9. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PubMed id 8694763)1, 2 Zolnierowicz S.... Hemmings B.A. (1996)
    10. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. (PubMed id 8254721)1, 2 Ruediger R.... Walter G. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5518 HGNC: 9302 AceView: PPP2R1A Ensembl:ENSG00000105568 euGenes: HUgn5518
    ECgene: PPP2R1A Kegg: 5518 H-InvDB: PPP2R1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP2R1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2R1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP2R1A gene:
    Search GeneIP for patents involving PPP2R1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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