PPP2CB Gene
protein-coding GIFtS: 64
GCID: GC08M030631
|
|
protein phosphatase 2, catalytic subunit, beta isozyme(Previous names: protein phosphatase 2 (formerly 2A), catalytic subunit,...)
| |
Aliases
for PPP2CB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme1 2 | | Protein Phosphatase 2, Catalytic Subunit, Beta Isoform2 | | PP2Abeta1 2 | | Protein Phosphatase 2A Catalytic Subunit, Beta Isoform2 | | Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform1 2 | | Protein Phosphatase Type 2A Catalytic Subunit2 | | PP2A-Beta1 | | Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform2 | | EC 3.1.3.163 8 | | Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform2 | | PP2CB2 | | |
Export aliases for PPP2CB gene to outside databasesPrevious GC identifers: GC08M030548 GC08M031095 GC08M030499 GC08M030700 GC08M030762 GC08M029189 |
Summaries
for PPP2CB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPP2CB:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thrphosphatases, and it is implicated in the negative control of cell growth and division. It consists of a commonheteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associateswith a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. (provided by RefSeq,Mar 2010)
UniProtKB/Swiss-Prot: PP2AB_HUMAN, P62714Function: PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, andMAP-2 kinase
 summary
for PPP2CB: Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.
Gene Wiki entry for PPP2CB
|
Genomic Views
for PPP2CB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPP2CB gene promoter:
TBP STAT1 RelA LUN-1 AREB6 c-Rel POU2F1 POU2F1a COMP1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPP2CB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2CB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12PPP2CB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M030631: view genomic region
(about GC identifiers)
Start:
|
30,631,973 bp from pter |
End:
|
30,671,830 bp from pter |
Size:
|
39,858 bases |
Orientation:
|
minus strand |
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Proteins
for PPP2CB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PP2AB_HUMAN, P62714 (See
protein sequence)Recommended Name: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Size: 309 amino acids; 35575 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (Bysimilarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C)and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits.Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55,R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cellsignaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits
Subcellular location: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=Inprometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles
Secondary accessions: D3DSV4 P11082 Q6FHK5Explore the universe of human proteins at neXtProt for PPP2CB: NX_P62714
Post-translational modifications:
Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies duringthe cell cycle. Demethylated by PME1 (in vitro)1
Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results ininactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62714
4/24 DME Specific Peptides for PPP2CB (P62714) (see all 24)
PPP2CB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001009552.1
ENSEMBL proteins: ENSP00000429927 ENSP00000221138 ENSP00000428142 ENSP00000430758 ENSP00000428618 ENSP00000428866 ENSP00000384493 Reactome Protein details: P62714
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
PPP2CB for ontologies About GeneDecksing
PPP2CB Antibody Products:
Assay Products for PPP2CB: |
Protein
Domains /
Families
for PPP2CB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPP2CB for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62714ProtoNet protein and cluster: P62714 1 Blocks protein family: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
UniProtKB/Swiss-Prot: PP2AB_HUMAN, P62714Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily |
Function
for PPP2CB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PP2AB_HUMAN, P62714Function: PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, andMAP-2 kinaseCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphate Genatlas biochemistry entry for PPP2CB:protein phosphatase 2A,catalytic subunit,beta isoform
Enzyme Number (IUBMB): EC 3.1.3.161 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CB (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PPP2CB (NM_001009552) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP2CB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2CB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2CB |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
PPP2CB for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for PPP2CB:
Animal Models:
Mouse knock-out Ppp2cbtm1.1Nju for PPP2CB
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ppp2cb):
PPP2CB for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPP2CB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/67 super-pathways (see all 67) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | ERK/MAPK targets | | | 3 | M Phase | | | 4 | Signaling by FGFR | | | 5 | Cyclins and Cell Cycle Regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/11 EMD Millipore Pathways for PPP2CB (see all 11)
5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2CB (see all 24)
5 Tocris Bioscience Pathways for PPP2CB
5/12  GeneGo (Thomson Reuters) Pathways for PPP2CB (see all 12)
5/6  BioSystems Pathways for PPP2CB (see all 6)
5/70 
Reactome Pathways for PPP2CB (see all 70)
5/8 
Kegg Pathways (Kegg details for PPP2CB) (see all 8):
PPP2CB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPP2CB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/290 Interacting proteins for PPP2CB (P627141, 2, 3 ENSP000002211384) via UniProtKB, MINT, STRING, and/or I2D (see all 290)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006470 | protein dephosphorylation |
TAS | 2849765 | | GO:0008543 | fibroblast growth factor receptor signaling pathway |
TAS | -- | | GO:0010468 | regulation of gene expression |
IEA | -- | | GO:0042221 | response to chemical stimulus |
-- | -- | | GO:0042542 | response to hydrogen peroxide |
IEA | -- |
PPP2CB for ontologies About GeneDecksing
|
Drugs & Compounds
for PPP2CB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for PPP2CB available from Tocris Bioscience About this table
5 HMDB Compounds for PPP2CB About this table
1 DrugBank Compound for PPP2CB About this table
Search CenterWatch for drugs/clinical trials and news about PPP2CB / PP2AB
|
Transcripts
for PPP2CB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPP2CB gene (2 alternative transcripts): NM_001009552.1 NM_004156.2 Unigene Cluster for PPP2CB: Protein phosphatase 2, catalytic subunit, beta isozyme Hs.491440 [show with all ESTs]Unigene Representative Sequence: NM_00100955211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000523023 ENST00000221138(uc003xik.3) ENST00000518564 ENST00000518532
ENST00000522113 ENST00000520334 ENST00000523804 ENST00000518243 ENST00000520056
ENST00000520500 ENST00000406655
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CB (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPP2CB (NM_001009552) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPP2CB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2CB |
Additional cDNA sequence: AF444006.1 AK091875.1 BC012022.1 BT019526.1 CR541747.1 J03805.1 X12656.1 19 DOTS entries: DT.100727748 DT.100683823 DT.91767244 DT.100818504 DT.75117391 DT.100818497 DT.95343128 DT.91683361 DT.100692870 DT.121475822 DT.121475864 DT.121475867 DT.40116974 DT.91679510 DT.100818500 DT.120690475 DT.91767250 DT.100818499 DT.121475866 24/379 AceView cDNA sequences (see all 379): D57368 AI203157 BE671932 BM504562 BM264514 AL040309 AA195309 AI312549 AI077706 CD679419 AI934647 AW197625 BF195191 AI333400 BM760102 AA374611 BG167163 N46378 AI918704 H20878 BF591268 AI659470 AI096670 AV682731
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CB About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for PPP2CB
|
Expression
for PPP2CB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPP2CB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGTGCTTG
About this image
See PPP2CB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP2CB
SOURCE GeneReport for Unigene cluster: Hs.491440
SABiosciences Expression via Pathway-Focused PCR Array including PPP2CB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP2CB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPP2CB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2CB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2CB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2CB |
Orthologs
for PPP2CB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPP2CB gene from 8/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PPP2CB1 |
protein phosphatase 2, catalytic subunit, beta isozyme |
87.27(n)
97.09(a) |
|
396021 NM_205124.1 NP_990455.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PPP2CB6 |
-- |
98(a) |
1 ↔ 1 |
GL343257.1(325686-348387) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.66862 |
X.laevis mRNA for protein phosphatase 2A |
84.43(n) |
|
Z50852.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.51202 |
Danio rerio cDNA clone MGC55808 IMAGE3817676, complete more |
81.68(n) |
|
BC044495.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mts1 , 3 |
R7 cell fate commitment protein phosphatase
type more3
microtubule star1 |
94(a)
(best of 2)3
74.54(n)1
94.5(a)1 |
|
459591 NM_057457.31 NP_476805.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F38H4.93
let-921 |
serine/threonine protein phosphatase3
Protein LET-921 |
89(a)
(best of 18)3
72.53(n)1
89.58(a)1 |
|
IV(11858618-11859876)3
1781171 NM_069846.21 NP_502247.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PP2A-46PP2A-36(see all 5) |
serine/threonine-protein phosphatase PP2A-3 cataly...serine/threonine-protein phosphatase PP2A-4 cataly...(see all 5) |
79(a)79(a)(see all 5) |
possible orthologpossible ortholog(see all 5) |
3(21635226-21639105) 2(17697667-17701417) |
rice
(Oryza sativa) |
Liliopsida |
Os10g04106001 |
hypothetical protein |
71.44(n)
82.33(a) |
|
4348601 NM_001071113.1 NP_001064578.1 |
ENSEMBL Gene Tree for PPP2CB (if available)
TreeFam Gene Tree for PPP2CB (if available) |
Paralogs
for PPP2CB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPP2CB gene
- PPP4C2 PPP2CA2
12 SIMAP similar genes for PPP2CB using alignment to 6 protein entries: PP2AB_HUMAN (see all proteins):PPP2CA PPP4C SKP1 PPP6C PPP1CB PPP1CC
PPP1CA PPP5C PPP3CA PPP3CC PPP3CB PPEF1
PPP2CB for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PPP2CB
PGOHUM00000249065 PGOHUM00000257085
|
Genomic Variants
for PPP2CB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPP2CB (30631973 - 30671830 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPP2CB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP2CB |
|
Disorders
/ Diseases
for PPP2CB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPP2CB for disorders About GeneDecksing
OMIM gene information: 176916
OMIM disorders: --
16  diseases for PPP2CB: About MalaCardscerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 werner syndrome
chagas disease hepatitis c trypanosomiasis cerebritis
alzheimer's disease prostate cancer hepatitis prostatitis
immunodeficiency malaria neuronitis breast cancer
Export disorders for PPP2CB gene to outside databases
|
Publications
for PPP2CB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPP2CB gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with PPP2CB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PubMed id 1846293)1, 2, 9 Khew-Goodall Y.... Hemmings B.A. (1991)
- The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PubMed id 8206937)1, 2, 9 Favre B.... Hemmings B.A. (1994)
- Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PubMed id 10318862)1, 2 Ogris E....Pallas D.C. (1999)
- Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively. (PubMed id 8383590)1, 3 Jones T.A....Cohen P.T. (1993)
- Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. (PubMed id 2153055)1, 2 Pallas D.C.... Roberts T.M. (1990)
- Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. (PubMed id 2555176)1, 2 Virshup D.M.... Kelly T.J. (1989)
- The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit. (PubMed id 2849765)1, 2 Hemmings B.A....Stone S.R. (1988)
- Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. (PubMed id 2837763)1, 2 Arino J.... Johnson G.L. (1988)
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External Searches for PPP2CB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PPP2CB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PPP2CB gene
(According to HUGE)
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Specialized Databases showing PPP2CB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PPP2CB | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PPP2CB gene:
Search GeneIP for patents involving PPP2CB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PPP2CB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PPP2CB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP2CB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP2CB | | | OriGene Protein Over-expression Lysate for PPP2CB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPP2CB | | OriGene 3'-UTR Clone for PPP2CB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP2CB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP2CB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2CB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2CB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP2CB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP2CB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2CB |
|  |  |  | | | | ThermoFisher Antibodies for PPP2CB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2CB |
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