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PPP2CB Gene

protein-coding   GIFtS: 67
GCID: GC08M030631

Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme

(Previous names: protein phosphatase 2 (formerly 2A), catalytic subunit,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme1 2     PP2CB2
Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform1 2     Protein Phosphatase 2, Catalytic Subunit, Beta Isoform2
PP2A-beta2 3     Protein Phosphatase 2A Catalytic Subunit, Beta Isoform2
EC 3.1.3.163 8     Protein Phosphatase Type 2A Catalytic Subunit2
Beta Isoform1     Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform2
Protein Phosphatase 2A Catalytic Subunit1     Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform2
PP2Abeta2     

External Ids:    HGNC: 93001   Entrez Gene: 55162   Ensembl: ENSG000001046957   OMIM: 1769165   UniProtKB: P627143   

Export aliases for PPP2CB gene to outside databases

Previous GC identifers: GC08M030548 GC08M031095 GC08M030499 GC08M030700 GC08M030762 GC08M029189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2CB Gene:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr
phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common
heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that
associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit.
(provided by RefSeq, Mar 2010)

GeneCards Summary for PPP2CB Gene:
PPP2CB (protein phosphatase 2, catalytic subunit, beta isozyme) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP4C.

UniProtKB/Swiss-Prot: PP2AB_HUMAN, P62714
Function: PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase,
and MAP-2 kinase

summary for PPP2CB Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2CB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2CB gene promoter:
         TBP   STAT1   RelA   LUN-1   AREB6   c-Rel   POU2F1   POU2F1a   COMP1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2CB promoter sequence
   Search Chromatin IP Primers for PPP2CB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2CB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

PPP2CB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2CB gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M030631:  view genomic region     (about GC identifiers)

Start:
30,631,973 bp from pter      End:
30,671,830 bp from pter
Size:
39,858 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PP2AB_HUMAN, P62714 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform  
Size: 309 amino acids; 35575 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD
(By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit
(subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of
regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B
(the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral
proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through
regulatory B56 subunits. Interacts with CTTNBP2NL
Secondary accessions: D3DSV4 P11082 Q6FHK5

Explore the universe of human proteins at neXtProt for PPP2CB: NX_P62714

Explore proteomics data for PPP2CB at MOPED

Post-translational modifications: 

  • Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies
    during the cell cycle. Demethylated by PME1 (in vitro)1
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in
    inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation1
  • Ubiquitination2 at Lys21, Lys41, Lys136, Lys283
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP2CB (P62714) (see all 24)
     NYLFMGD  QEVPHEG  ELFRIGG  DLLWSDP 


    See PPP2CB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001009552.1  
    ENSEMBL proteins: 
     ENSP00000429927   ENSP00000221138   ENSP00000428142   ENSP00000430758   ENSP00000428618  
     ENSP00000428866  
    Reactome Protein details: P62714

    PPP2CB Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for PPP2CB (7 products) 

     
    antibodies-online peptides for PPP2CB

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    antibodies-online antibodies for PPP2CB (62 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry P62714

    ProtoNet protein and cluster: P62714

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PP2AB_HUMAN, P62714
    Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily


    Find genes that share domains with PPP2CB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP2AB_HUMAN, P62714
    Function: PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase,
    and MAP-2 kinase
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for PPP2CB:
    protein phosphatase 2A,catalytic subunit,beta isoform

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722contributes to protein serine/threonine phosphatase activity TAS8206937
    GO:0005515protein binding IPI10698523
    GO:0008022protein C-terminus binding IEA--
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with PPP2CB           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PPP2CB:
     Apoptosis resistance  Decreased cilium length after   Decreased focal adhesion (FA)   Decreased melanin production 
     Increased homologous recombina  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppp2cb):
     no phenotypic analysis  normal 

    Find genes that share phenotypes with PPP2CB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppp2cbtm1.1Nju for PPP2CB

       genOway: Develop your customized and physiologically relevant rodent model for PPP2CB

    miRNA
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    miRTarBase miRNAs that target PPP2CB:
    hsa-mir-421 (MIRT039452), hsa-mir-425-5p (MIRT016657)

    Block miRNA regulation of human, mouse, rat PPP2CB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2CB (see all 11):
    hsa-miR-183 hsa-miR-133b hsa-miR-4282 hsa-miR-132 hsa-miR-455-3p hsa-miR-214 hsa-miR-133a hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidPPP2CB 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2CB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP2AB_HUMAN, P62714: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In
    prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle
    poles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    endoplasmic reticulum1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex TAS8206937
    GO:0000775chromosome, centromeric region IEA--
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    Find genes that share ontologies with PPP2CB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2CB About   (see all 72)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    Cell Cycle Control by BTG Proteins0.36
    Cyclin D associated events in G10.31
    2Ca-dependent events
    Opioid Signalling0.54
    Development Beta adrenergic receptors signaling via cAMP0.32
    Signal transduction Calcium signaling0.35
    3Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    4Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    DARPP-32 events0.32
    5Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69


    Find genes that share SuperPaths with PPP2CB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2CB (see all 24)
        Cell Cycle Control by BTG Proteins
    CDK5 Pathway
    mTOR Pathway
    AMPK Enzyme Complex Pathway
    Cyclins and Cell Cycle Regulation

    5 Tocris Bioscience Pathways for PPP2CB
        Akt Pathway
    Insulin Pathway
    TGF-beta Pathway
    mTOR Pathway
    Wnt Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PPP2CB (see all 12)
        Apoptosis and survival BAD phosphorylation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction AKT signaling
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PPP2CB (see all 8)
        Diurnally regulated genes with circadian orthologs
    Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    IL-6 Signaling Pathway
    Monoamine Transport


    Selected Reactome Pathways for PPP2CB (see all 19)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    ERKs are inactivated
    DARPP-32 events
    Cyclin A/B1 associated events during G2/M transition


    Selected Kegg Pathways  (Kegg details for PPP2CB) (see all 11):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including PPP2CB: 
              Protein Phosphatases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PPP2CB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2CB (P627141, 2, 3 ENSP000002211384) via UniProtKB, MINT, STRING, and/or I2D (see all 420)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS2849765
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0010468regulation of gene expression IEA--
    GO:0034976response to endoplasmic reticulum stress IEA--

    Find genes that share ontologies with PPP2CB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PPP2CB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    5 HMDB Compounds for PPP2CB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PPP2CB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP2CB gene (2 alternative transcripts): 
    NM_001009552.1  NM_004156.2  

    Unigene Cluster for PPP2CB:

    Protein phosphatase 2, catalytic subunit, beta isozyme
    Hs.491440  [show with all ESTs]
    Unigene Representative Sequence: NM_001009552
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523023 ENST00000221138(uc003xik.3) ENST00000518564 ENST00000518532
    ENST00000522113 ENST00000520334 ENST00000523804 ENST00000518243 ENST00000520056
    ENST00000520500
    miRNA
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    hsa-miR-183 hsa-miR-133b hsa-miR-4282 hsa-miR-132 hsa-miR-455-3p hsa-miR-214 hsa-miR-133a hsa-miR-32*
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      QuantiFast Probe-based Assays in human, mouse, rat PPP2CB

    Additional mRNA sequence: 

    AF444006.1 AK091875.1 BC012022.1 BT019526.1 CR541747.1 J03805.1 X12656.1 

    19 DOTS entries:

    DT.100727748  DT.100683823  DT.91767244  DT.100818504  DT.75117391  DT.100818497  DT.95343128  DT.91683361 
    DT.100692870  DT.121475822  DT.121475864  DT.121475867  DT.40116974  DT.91679510  DT.100818500  DT.120690475 
    DT.91767250  DT.100818499  DT.121475866 

    Selected AceView cDNA sequences (see all 379):

    CR611096 AW002663 BF438886 AA325278 BF196082 AI797615 AU120870 AI651013 
    BU902640 CB136065 BF591268 BM905784 H22121 AL521353 AV682731 AI333400 
    BQ775355 D57368 CD679419 AI077706 CR624064 N50092 AA099302 BM800216 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CB    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                -                             -                     
    SP2:                                -                                                   
    SP3:                          -     -                                                   
    SP4:                                                                                    
    SP5:              -     -     -     -     -     -     -     -     -     -               


    ECgene alternative splicing isoforms for PPP2CB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP2CB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGTGCTTG
    PPP2CB Expression
    About this image


    PPP2CB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
    PPP2CB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2CB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491440
        Pathway & Disease-focused RT2 Profiler PCR Array including PPP2CB: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PPP2CB
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2CB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2CB gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2cb1 , 5 protein phosphatase 2 (formerly 2A), catalytic subunit, more1, 5 92.13(n)1
    100(a)1
      8 (20.63 cM)5
    190531  NM_017374.31  NP_059070.11 
     335996215 
    chicken
    (Gallus gallus)
    Aves PPP2CB1 protein phosphatase 2, catalytic subunit, beta isozyme 87.27(n)
    97.09(a)
      396021  NM_205124.1  NP_990455.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2CB6
    protein phosphatase 2, catalytic subunit, beta iso...
    98(a)
    1 ↔ 1
    GL343257.1(173957-348403)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66862 X.laevis mRNA for protein phosphatase 2A 84.43(n)    Z50852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.51202 Danio rerio cDNA clone MGC55808 IMAGE3817676, complete more 81.68(n)    BC044495.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mts3 R7 cell fate commitment protein
    phosphatase type more
    94(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F38H4.93 serine/threonine protein phosphatase 89(a)
    (best of 18)
      IV(11858618-11859876)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPH21(YDL134C)4
    PPH221
    Catalytic subunit of protein phosphatase 2A (PP2A), more4
    PPH221
    66.67(n)1
    75.83(a)1
      4(220771-219662)4
    8513391  NP_010093.11  8514214 
     NP_010147.14 
    soybean
    (Glycine max)
    eudicotyledons Gma.107982 Transcribed sequence with strong similarity to protein more 78.31(n)  
    rice
    (Oryza sativa)
    Liliopsida Os10g04106001 Os10g0410600 71.44(n)
    82.33(a)
      4348601  NM_001071113.1  NP_001064578.1 


    ENSEMBL Gene Tree for PPP2CB (if available)
    TreeFam Gene Tree for PPP2CB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2CB gene
    PPP4C2  PPP2CA2  
    11 SIMAP similar genes for PPP2CB using alignment to 6 protein entries:     PP2AB_HUMAN (see all proteins):
    PPP2CA    CDKL3    PPP4C    PPP6C    PPP1CB    PPP1CC
    PPP1CA    PPP5C    PPP3CA    PPP3CC    PPP3CB

    Find genes that share paralogs with PPP2CB           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PPP2CB
    PGOHUM00000249065 PGOHUM00000257085


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2CB (see all 584)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1169420361,2
    F--30642648(+) ACCATG/ACCCAG 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1409153231,2
    --30642787(+) GCTTTC/GAAAGA 1 -- ds50010--------
    rs1915388341,2
    --30642940(+) AATTAC/GCTGGG 1 -- ds50010--------
    rs11314071,2
    C--30643145(-) TTTTCA/GTTTTA 1 -- ut313Minor allele frequency- G:0.04NA 124
    rs788667791,2
    C,F--30643241(+) TTAGTT/CTAAAT 1 -- ut311Minor allele frequency- C:0.05WA 118
    rs1848594691,2
    --30643409(+) CATGCC/TAGTTA 1 -- ut310--------
    rs1901593851,2
    --30643444(+) TAAGCA/GCAAAA 1 -- ut310--------
    rs1385349061,2
    C--30643454(+) AGGAGA/TTGAAG 1 -- ut310--------
    rs1415652421,2
    --30643484(+) CTTGAA/GCAGTC 1 -- ut310--------
    rs1128656281,2
    C--30643539(+) TGACC-/CTA   
      T
    /TATC
    TAGAA
    2 -- ut311CSA 2

    HapMap Linkage Disequilibrium report for PPP2CB (30631973 - 30671830 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPP2CB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273921CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2CB
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2CB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176916    OMIM disorders: --


    Find genes that share disorders with PPP2CB           About GenesLikeMe


    Export disorders for PPP2CB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP2CB gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with PPP2CB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PubMed id 1846293)1, 2, 9 Khew-Goodall Y.... Hemmings B.A. (Biochemistry 1991)
    2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1, 2, 9 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    3. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PubMed id 8206937)1, 2, 9 Favre B.... Hemmings B.A. (J. Biol. Chem. 1994)
    4. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. (PubMed id 10318862)1, 2 Ogris E....Pallas D.C. (J. Biol. Chem. 1999)
    7. Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23--&gt;q31 and 8p12--&gt;p11.2, respectively. (PubMed id 8383590)1, 3 Jones T.A....Cohen P.T. (Cytogenet. Cell Genet. 1993)
    8. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. (PubMed id 2153055)1, 2 Pallas D.C.... Roberts T.M. (Cell 1990)
    9. Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. (PubMed id 2555176)1, 2 Virshup D.M.... Kelly T.J. (EMBO J. 1989)
    10. The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit. (PubMed id 2849765)1, 2 Hemmings B.A....Stone S.R. (Nucleic Acids Res. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5516 HGNC: 9300 AceView: PPP2CB Ensembl:ENSG00000104695 euGenes: HUgn5516
    ECgene: PPP2CB Kegg: 5516 H-InvDB: PPP2CB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP2CB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP2CB gene:
    Search GeneIP for patents involving PPP2CB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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