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Aliases for PPP2CB Gene

Aliases for PPP2CB Gene

  • Protein Phosphatase 2 Catalytic Subunit Beta 2 3
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform 2 3
  • EC 3.1.3.16 4 63
  • PP2A-Beta 3 4
  • Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform 3
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isoform 3
  • Protein Phosphatase 2A Catalytic Subunit, Beta Isoform 3
  • Protein Phosphatase Type 2A Catalytic Subunit 3
  • Protein Phosphatase 2A Catalytic Subunit 2
  • Testicular Tissue Protein Li 146 3
  • Beta Isoform 2
  • PP2Abeta 3
  • PP2CB 3

External Ids for PPP2CB Gene

Previous GeneCards Identifiers for PPP2CB Gene

  • GC08M030548
  • GC08M031095
  • GC08M030499
  • GC08M030700
  • GC08M029189
  • GC08M030631

Summaries for PPP2CB Gene

Entrez Gene Summary for PPP2CB Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPP2CB Gene

PPP2CB (Protein Phosphatase 2 Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and AMPK signaling pathway. GO annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP4C.

UniProtKB/Swiss-Prot for PPP2CB Gene

  • PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Tocris Summary for PPP2CB Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2CB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CB Gene

Genomics for PPP2CB Gene

Regulatory Elements for PPP2CB Gene

Enhancers for PPP2CB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP2CB on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP2CB Gene

Chromosome:
8
Start:
30,774,457 bp from pter
End:
30,814,314 bp from pter
Size:
39,858 bases
Orientation:
Minus strand

Genomic View for PPP2CB Gene

Genes around PPP2CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CB Gene

Proteins for PPP2CB Gene

  • Protein details for PPP2CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62714-PP2AB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
    Protein Accession:
    P62714
    Secondary Accessions:
    • D3DSV4
    • P11082
    • Q6FHK5

    Protein attributes for PPP2CB Gene

    Size:
    309 amino acids
    Molecular mass:
    35575 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL.

neXtProt entry for PPP2CB Gene

Proteomics data for PPP2CB Gene at MOPED

Post-translational modifications for PPP2CB Gene

  • May be monoubiquitinated by NOSIP.
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CB Gene

Domains & Families for PPP2CB Gene

Gene Families for PPP2CB Gene

Graphical View of Domain Structure for InterPro Entry

P62714

UniProtKB/Swiss-Prot:

PP2AB_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CB: view

Function for PPP2CB Gene

Molecular function for PPP2CB Gene

GENATLAS Biochemistry:
protein phosphatase 2A,catalytic subunit,beta isoform
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Enzyme Numbers (IUBMB) for PPP2CB Gene

Gene Ontology (GO) - Molecular Function for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 9647778
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP2CB: view
genes like me logo Genes that share phenotypes with PPP2CB: view

Animal Models for PPP2CB Gene

MGI Knock Outs for PPP2CB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP2CB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CB Gene

Localization for PPP2CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CB Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP2CB Gene COMPARTMENTS Subcellular localization image for PPP2CB gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Pathways & Interactions for PPP2CB Gene

SuperPathways for PPP2CB Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 MyD88 cascade initiated on plasma membrane
3 S45 mutants of beta-catenin arent phosphorylated
4 PI3K events in ERBB4 signaling
5 DAG and IP3 signaling
genes like me logo Genes that share pathways with PPP2CB: view

SIGNOR curated interactions for PPP2CB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0010468 regulation of gene expression IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Drugs & Compounds for PPP2CB Gene

(8) Drugs for PPP2CB Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Target 382,385
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
microcystin-lr Pharma Inhibitor of protein phosphatase PP1/PP2A,potent and selective 0
Sal 003 Pharma Cellular phosphatase complex inhibitor 0

(6) Additional Compounds for PPP2CB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Ceramide
3102-57-6

(5) Tocris Compounds for PPP2CB Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8

(2) ApexBio Compounds for PPP2CB Gene

Compound Action Cas Number
Microcystin-LR Inhibitor of protein phosphatase PP1/PP2A,potent and selective 101043-37-2
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP2CB: view

Transcripts for PPP2CB Gene

Unigene Clusters for PPP2CB Gene

Protein phosphatase 2, catalytic subunit, beta isozyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - - - - - - - - -

Relevant External Links for PPP2CB Gene

GeneLoc Exon Structure for
PPP2CB
ECgene alternative splicing isoforms for
PPP2CB

Expression for PPP2CB Gene

mRNA expression in normal human tissues for PPP2CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2CB Gene

This gene is overexpressed in Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP2CB Gene



SOURCE GeneReport for Unigene cluster for PPP2CB Gene Hs.491440

genes like me logo Genes that share expression patterns with PPP2CB: view

Protein tissue co-expression partners for PPP2CB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP2CB Gene

Orthologs for PPP2CB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP2CB 35
  • 93.2 (n)
  • 99.68 (a)
PPP2CB 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2CB 35
  • 95.15 (n)
  • 100 (a)
PPP2CB 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2cb 35
  • 92.13 (n)
  • 100 (a)
Ppp2cb 16
Ppp2cb 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2CB 35
  • 99.89 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Ppp2cb 35
  • 93.1 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2CB 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2CB 35
  • 87.27 (n)
  • 97.09 (a)
PPP2CA 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2CB 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2cb 35
  • 84.47 (n)
  • 98.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6686 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5120 35
ppp2cb 35
  • 81.45 (n)
  • 99.68 (a)
ppp2cb 36
  • 100 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11597 37
  • 51 (a)
mts 37
  • 94 (a)
mts 36
  • 94 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A1.3 37
  • 40 (a)
C23G10.1a 37
  • 38 (a)
C23G10.1b 37
  • 38 (a)
C24H11.1 37
  • 38 (a)
C24H11.2 37
  • 38 (a)
C25A6.1 37
  • 44 (a)
C27B7.6 37
  • 33 (a)
C34C12.3 37
  • 52 (a)
F38H4.9 37
  • 89 (a)
F42G8.8 37
  • 34 (a)
F49E11.7 37
  • 32 (a)
F58G1.3 37
  • 36 (a)
pph-4.1 37
  • 63 (a)
pph-4.2 37
  • 61 (a)
R08A2.2 37
  • 35 (a)
R13A5.11 37
  • 37 (a)
W03D8.2 37
  • 40 (a)
Y40H4A.2 37
  • 39 (a)
let-92 36
  • 86 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR099C 35
  • 64.57 (n)
  • 75.17 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05357g 35
  • 66.56 (n)
  • 76.41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH22 35
  • 66.67 (n)
  • 75.83 (a)
PPH21 36
  • 62 (a)
ManyToMany
PPH22 36
  • 61 (a)
ManyToMany
PPH21 38
soybean
(Glycine max)
eudicotyledons Gma.10798 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9171 35
barley
(Hordeum vulgare)
Liliopsida Hv.6175 35
rice
(Oryza sativa)
Liliopsida Os10g0410600 35
  • 71.44 (n)
  • 82.33 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.11307 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06630 35
  • 70 (n)
  • 86.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa2 35
  • 68.73 (n)
  • 78.5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11024 36
  • 90 (a)
OneToMany
Species with no ortholog for PPP2CB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP2CB Gene

ENSEMBL:
Gene Tree for PPP2CB (if available)
TreeFam:
Gene Tree for PPP2CB (if available)

Paralogs for PPP2CB Gene

Paralogs for PPP2CB Gene

(11) SIMAP similar genes for PPP2CB Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PPP2CB Gene

genes like me logo Genes that share paralogs with PPP2CB: view

Variants for PPP2CB Gene

Sequence variations from dbSNP and Humsavar for PPP2CB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7833839 -- 30,793,330(+) gaata(C/T)aacct intron-variant
rs7835654 -- 30,788,549(+) ccagc(A/C)atgtt intron-variant
rs7839078 -- 30,805,572(+) AACAA(A/C)AAAAA intron-variant
rs7839620 -- 30,799,314(+) TAAAG(G/T)CAAAT intron-variant
rs7843540 -- 30,795,360(+) TCCGC(C/T)CGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2CB Gene

Variant ID Type Subtype PubMed ID
esv273921 CNV Insertion 20981092

Variation tolerance for PPP2CB Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2CB Gene

HapMap Linkage Disequilibrium report
PPP2CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CB Gene

Disorders for PPP2CB Gene

Relevant External Links for PPP2CB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2CB

No disorders were found for PPP2CB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2CB Gene

Publications for PPP2CB Gene

  1. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PMID: 1846293) Khew-Goodall Y. … Hemmings B.A. (Biochemistry 1991) 3 4 23 67
  2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PMID: 8206937) Favre B. … Hemmings B.A. (J. Biol. Chem. 1994) 3 23

Products for PPP2CB Gene

Sources for PPP2CB Gene

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