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PPP2CA Gene

protein-coding   GIFtS: 71
GCID: GC05M133530

Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme

(Previous names: protein phosphatase 2 (formerly 2A), catalytic subunit,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme1 2     Protein Phosphatase 2A Catalytic Subunit1
Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform1 2     PP2Ac2
Replication Protein C2 3     PP2CA2
PP2A-alpha2 3     PP2Calpha2
RP-C2 3     Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform2
EC 3.1.3.163 8     Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform2
Alpha Isoform1     Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Alpha Isoform2

External Ids:    HGNC: 92991   Entrez Gene: 55152   Ensembl: ENSG000001135757   OMIM: 1769155   UniProtKB: P677753   

Export aliases for PPP2CA gene to outside databases

Previous GC identifers: GC05M133180 GC05M134046 GC05M133563 GC05M133608 GC05M133560 GC05M128717


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP2CA Gene:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr
phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common
heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that
associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PPP2CA Gene:
PPP2CA (protein phosphatase 2, catalytic subunit, alpha isozyme) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2CB.

UniProtKB/Swiss-Prot: PP2AA_HUMAN, P67775
Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity
of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2
to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By
similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at
'Ser-259'

summary for PPP2CA Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2CA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP2CA gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   STAT1alpha   Arnt   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP2CA promoter sequence
   Search Chromatin IP Primers for PPP2CA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP2CA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

PPP2CA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2CA gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M133530:  view genomic region     (about GC identifiers)

Start:
133,530,025 bp from pter      End:
133,561,950 bp from pter
Size:
31,926 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PP2AA_HUMAN, P67775 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform  
Size: 309 amino acids; 35594 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit
(subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety
of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits
B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit,
viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity).
Interacts with TP53, SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts
with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3.
Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination.
Interacts with GSK3B (via C2 domain)
Selected PDB 3D structures from and Proteopedia for PPP2CA (see all 16):
2IAE (3D)        2IE3 (3D)        2IE4 (3D)        2NPP (3D)        2NYL (3D)        2NYM (3D)    
Secondary accessions: P05323 P13197
Alternative splicing: 2 isoforms:  P67775-1   P67775-2   (Catalytically inactive, shows enhanced binding to IGBP1, and does not interact with the scaffolding subunit PPP2R1A)

Explore the universe of human proteins at neXtProt for PPP2CA: NX_P67775

Explore proteomics data for PPP2CA at MOPED

Post-translational modifications: 

  • Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly, enhancing
    the affinity of the PP2A core enzyme for some, but not all, regulatory subunits. It varies during the cell cycle1
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in
    inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation1
  • Ubiquitination2 at Lys8, Lys21, Lys29, Lys41, Lys136, Lys283
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPP2CA (P67775) (see all 26)
     NYLFMGD  QLSESQV  QEVPHEG  ELFRIGG 


    See PPP2CA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002706.1  
    ENSEMBL proteins: 
     ENSP00000418447   ENSP00000430869   ENSP00000428816  
    Reactome Protein details: P67775

    PPP2CA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PPP2CA
    OriGene Protein Over-expression Lysate for PPP2CA
    OriGene MassSpec for PPP2CA
    OriGene Custom Protein Services for PPP2CA
    GenScript Custom Purified and Recombinant Proteins Services for PPP2CA
    Novus Biologicals PPP2CA Protein
    Novus Biologicals PPP2CA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PPP2CA 

     
    antibodies-online proteins for PPP2CA (9 products) 

     
    Search antibodies-online for peptides for PPP2CA

    PPP2CA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPP2CA
    R&D Systems Antibodies for PPP2CA (PP2A)
    Cell Signaling Technology (CST) Antibodies for PPP2CA 
    OriGene Antibodies for PPP2CA
    OriGene Custom Antibody Services for PPP2CA
    Novus Biologicals PPP2CA Antibodies
    Abcam antibodies for PPP2CA (P67775, P62714)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPP2CA
    antibodies-online antibodies for PPP2CA (3 products) 

    PPP2CA Assay Products:

    EMD Millipore Kits and Assays for the Analysis of PPP2CA
    OriGene Custom Assay Services for PPP2CA
    R&D Systems ELISAs for PPP2CA (PP2A)         (see all)
    GenScript Custom Assay Services for PPP2CA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PPP2CA 
    antibodies-online kits for PPP2CA (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP: Serine/threonine phosphatases / Protein phosphatase, catalytic subunits

    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry P67775

    ProtoNet protein and cluster: P67775

    1 Blocks protein domain: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PP2AA_HUMAN, P67775
    Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily


    Find genes that share domains with PPP2CA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP2AA_HUMAN, P67775
    Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity
    of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2
    to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By
    similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at
    'Ser-259'
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for PPP2CA:
    protein phosphatase 2A,catalytic subunit,alpha isoform,antagonizing cdc2/CCNB1 complex which regulates the G2-M
    transition in the cell cycle

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IEA--
    GO:0005515protein binding IPI11591705
    GO:0008022protein C-terminus binding IEA--
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with PPP2CA           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PPP2CA:
     Decreased focal adhesion (FA)   Increased apoptosis  Increased cell number in S and  Increased mitotic exit time 
     Upregulation of Wnt/beta-caten 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppp2ca):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  integument 
     liver/biliary system  mortality/aging  normal 

    Find genes that share phenotypes with PPP2CA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PPP2CA: Ppp2catm1.2Nju Ppp2catm1Gotz

       genOway: Develop your customized and physiologically relevant rodent model for PPP2CA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPP2CA:
    hsa-mir-197-3p (MIRT048079), hsa-mir-340-3p (MIRT043848)

    Block miRNA regulation of human, mouse, rat PPP2CA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPP2CA (see all 67):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-106a hsa-miR-200a hsa-miR-550a* hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidPPP2CA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPP2CA
    Predesigned siRNA for gene silencing in human, mouse, rat PPP2CA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPP2CA

    Clone
    Products:
         
    OriGene clones in human, mouse for PPP2CA (see all 6)
    OriGene ORF clones in mouse, rat for PPP2CA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPP2CA (NM_002715)
    Sino Biological Human cDNA Clone for PPP2CA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP2CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2CA
    Addgene plasmids for PPP2CA 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PPP2CA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2CA

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12240) for PPP2CA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PP2AA_HUMAN, P67775: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In
    prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle
    poles. Centromeric localization requires the presence of SGOL2 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    mitochondrion5
    nucleus5
    plasma membrane2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex TAS11007961
    GO:0000775chromosome, centromeric region IEA--
    GO:0000922spindle pole IEA--
    GO:0005634nucleus NAS11007961
    GO:0005737cytoplasm ----

    Find genes that share ontologies with PPP2CA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP2CA About   (see all 87)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    ERKs are inactivated0.00
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    Cell Cycle Control by BTG Proteins0.36
    Cyclin D associated events in G10.31
    3Ca-dependent events
    Opioid Signalling0.54
    Development Beta adrenergic receptors signaling via cAMP0.32
    Signal transduction Calcium signaling0.35
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    DARPP-32 events0.32


    Find genes that share SuperPaths with PPP2CA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PPP2CA
        TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP2CA (see all 24)
        Cell Cycle Control by BTG Proteins
    CDK5 Pathway
    mTOR Pathway
    AMPK Enzyme Complex Pathway
    Cyclins and Cell Cycle Regulation

    3 Cell Signaling Technology (CST) Pathways for PPP2CA
        Phosphatases
    MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    5 Tocris Bioscience Pathways for PPP2CA
        Akt Pathway
    Insulin Pathway
    TGF-beta Pathway
    mTOR Pathway
    Wnt Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PPP2CA (see all 12)
        Apoptosis and survival BAD phosphorylation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction AKT signaling
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PPP2CA (see all 15)
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    BDNF signaling pathway
    Wnt Signaling Pathway NetPath
    IL-6 Signaling Pathway


    Selected Reactome Pathways for PPP2CA (see all 21)
        Resolution of Sister Chromatid Cohesion
    Initiation of Nuclear Envelope Reformation
    Mitotic Prometaphase
    ERKs are inactivated
    DARPP-32 events

    1 PharmGKB Pathway for PPP2CA
        Diuretics Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PPP2CA) (see all 11):
        mRNA surveillance pathway
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2CA (see all 6): 
              mTOR Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPP2CA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP2CA (P677751, 2, 3 ENSP000004184474) via UniProtKB, MINT, STRING, and/or I2D (see all 467)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237155P466951, 2, 3, ENSP000003979564EBI-712311,EBI-1748945 MINT-2835686 MINT-2835661 I2D: score=1 STRING: ENSP00000397956
    RELAQ042061, 2, 3, ENSP000003842734EBI-712311,EBI-73886 MINT-8208073 MINT-8206588 MINT-8207858 MINT-8208045 MINT-8207553 MINT-8313257 I2D: score=4 STRING: ENSP00000384273
    ENSG00000206478P466951, 2, 3EBI-712311,EBI-1748945 MINT-2835686 MINT-2835661 I2D: score=1 
    ENSG00000227231P466951, 2, 3EBI-712311,EBI-1748945 MINT-2835686 MINT-2835661 I2D: score=1 
    ENSG00000230128P466951, 2, 3EBI-712311,EBI-1748945 MINT-2835686 MINT-2835661 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000188inactivation of MAPK activity NAS11007961
    GO:0000278mitotic cell cycle TAS--
    GO:0001932regulation of protein phosphorylation ----
    GO:0006275regulation of DNA replication NAS11007961

    Find genes that share ontologies with PPP2CA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PPP2CA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    6 HMDB Compounds for PPP2CA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for PPP2CA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 17016423
    (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-- --target--10592235
    2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid-- --target--10592235

    5 Novoseek inferred chemical compound relationships for PPP2CA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 70 2 10191253 (1), 10026142 (1)
    okadaic acid 60 1 8529028 (1)
    serine 59.7 2 10191253 (1), 10026142 (1)
    leucine 48.7 6 10191253 (2), 9877231 (1), 17662254 (1), 8206937 (1) (see all 5)
    glucose 0 13 14970009 (5), 9877231 (1)



    Find genes that share compounds with PPP2CA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP2CA gene: 
    NM_002715.2  

    Unigene Cluster for PPP2CA:

    Protein phosphatase 2, catalytic subunit, alpha isozyme
    Hs.105818  [show with all ESTs]
    Unigene Representative Sequence: BX640662
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481195(uc003kze.3) ENST00000472253 ENST00000495833 ENST00000522385
    ENST00000523082 ENST00000231504
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    hsa-miR-548j hsa-miR-582-3p hsa-miR-106a hsa-miR-200a hsa-miR-550a* hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b
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    Additional mRNA sequence: 

    AB451240.1 AB451365.1 AK057424.1 AK097599.1 BC000400.2 BC002657.2 BC019275.1 BC031696.1 
    BX640662.1 CR457417.1 

    Selected DOTS entries (see all 39):

    DT.70104269  DT.95165446  DT.97776346  DT.100672537  DT.97773863  DT.101986353  DT.120801791  DT.100672543 
    DT.305787  DT.91781757  DT.100013274  DT.120801594  DT.95101683  DT.423150  DT.86998477  DT.100038352 
    DT.99963260  DT.100652923  DT.120801881  DT.91781763  DT.100672539  DT.120801728  DT.120801815  DT.87079217 

    Selected AceView cDNA sequences (see all 636):

    BM999327 BP343484 AI273188 AA143057 AI075233 BQ016756 BG618120 AU132408 
    F05133 CR594899 AW024164 BU194836 AJ709896 BG676478 BI461208 CB148946 
    BM460992 BQ084189 AW173011 AI061293 BE504360 T25873 AW006530 CF129802 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CA (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -     -                 -     -                             -                     
    SP2:                                                                                                            
    SP3:                          -     -                 -     -                                                   
    SP4:                          -     -           -     -     -                                                   
    SP5:                                -                 -     -                                                   


    ECgene alternative splicing isoforms for PPP2CA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPP2CA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTCTTTG
    PPP2CA Expression
    About this image


    PPP2CA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PPP2CA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP2CA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105818
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPP2CA (see all 6): 
              mTOR Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2CA gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp2ca1 , 5 protein phosphatase 2 (formerly 2A), catalytic subunit, more1, 5 94.28(n)1
    99.68(a)1
      11 (31.86 cM)5
    190521  NM_019411.41  NP_062284.11 
     520986815 
    chicken
    (Gallus gallus)
    Aves PPP2CA1 protein phosphatase 2, catalytic subunit, alpha isozyme 88.67(n)
    99.03(a)
      416318  NM_001006152.1  NP_001006152.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPP2CA6
    protein phosphatase 2, catalytic subunit, alpha is...
    99(a)
    1 ↔ 1
    2(130843759-130864272)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppp2ca-prov2 protein phosphatase 2 (formerly 2A), catalytic subunit, more 83.06(n)    BC042272.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:560641 zgc:56064 79.94(n)
    97.09(a)
      393885  NM_200911.2  NP_957205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mts1 , 3 R7 cell fate commitment protein
    phosphatase type more3
    microtubule star1
    93(a)
    (best of 2)3
    73.03(n)1
    93.85(a)1
      459591  NM_057457.31  NP_476805.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F38H4.93
    let-921
    serine/threonine protein phosphatase3
    let-921
    89(a)
    (best of 15)3
    73.4(n)1
    89.25(a)1
      IV(11858618-11859876)3
    1781171  NM_069846.31  NP_502247.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPH216
    PPH226
    Catalytic subunit of protein phosphatase 2A (PP2A)...
    Catalytic subunit of protein phosphatase 2A (PP2A)...
    62(a)
    61(a)
    many ↔ many
    many ↔ many
    IV(219662-220771) YDL134C
    IV(123865-124998) YDL188C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PP2A-11 PP2A-1 70.65(n)
    80.4(a)
      842276  NM_104676.4  NP_176192.1 
    rice
    (Oryza sativa)
    Liliopsida AK099604.12   -- 75.16(n)    AK099604.1 


    ENSEMBL Gene Tree for PPP2CA (if available)
    TreeFam Gene Tree for PPP2CA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP2CA gene
    PPP2CB2  PPP4C2  
    11 SIMAP similar genes for PPP2CA using alignment to 5 protein entries:     PP2AA_HUMAN (see all proteins):
    CDKL3    PPP2CB    PPP4C    PPP6C    PPP1CB    PPP1CC
    PPP1CA    PPP5C    PPP3CA    PPP3CC    PPP3CB

    Find genes that share paralogs with PPP2CA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PPP2CA
    PGOHUM00000243980


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP2CA (see all 604)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781244101,2
    C--133531695(+) TATTTG/TTTCAG 1 -- ds50010--------
    rs1806926911,2
    --133531702(+) TCAGTC/TGGAGA 1 -- ds50010--------
    rs1852702591,2
    --133531712(+) AGAAAA/GGGCAT 1 -- ds50010--------
    rs1420575301,2
    --133531819(+) GCTTTC/GGAAAA 1 -- ds50010--------
    rs2019065901,2
    C--133531820(+) CTTTGA/GAAAAT 1 -- ds50010--------
    rs1904235951,2
    --133531863(+) TAGATC/TAGAAA 1 -- ds50010--------
    rs1811803281,2
    --133532029(+) TAAAAC/TATCAA 1 -- ds50010--------
    rs1446571011,2
    --133532162(+) TGTACA/GTAAGA 1 -- ut310--------
    rs1869088391,2
    --133532199(+) CTATTC/TGGTTT 1 -- ut310--------
    rs10524691,2
    C,H--133532454(-) GGGTTT/GTGTTT 1 -- ut312Minor allele frequency- G:0.00MN NS 360

    HapMap Linkage Disequilibrium report for PPP2CA (133530025 - 133561950 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PPP2CA: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP2CA
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP2CA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176915    OMIM disorders: --


    Find genes that share disorders with PPP2CA           About GenesLikeMe

    Genetic Association Database (GAD): PPP2CA
    Human Genome Epidemiology (HuGE) Navigator: PPP2CA (3 documents)

    Export disorders for PPP2CA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PPP2CA gene, integrated from 10 sources (see all 257):
    (articles sorted by number of sources associating them with PPP2CA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. (PubMed id 10191253)1, 2, 9 Bryant J.C.... Wadzinski B.E. (Biochem. J. 1999)
    2. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PubMed id 8206937)1, 2, 9 Favre B.... Hemmings B.A. (J. Biol. Chem. 1994)
    3. Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit. (PubMed id 22167190)1, 2 Migueleti D.L.... Zanchin N.I. (J. Biol. Chem. 2012)
    4. Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation. (PubMed id 22613722)1, 2 Watkins G.R.... Wadzinski B.E. (J. Biol. Chem. 2012)
    5. Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. (PubMed id 20092282)1, 2 McConnell J.L.... Wadzinski B.E. (Biochemistry 2010)
    6. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    7. Alpha4 is an essential regulator of PP2A phosphatase activity. (PubMed id 19818709)1, 2 Kong M.... Thompson C.B. (Mol. Cell 2009)
    8. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. (PubMed id 17485487)1, 2 Huang H.... Yen T.J. (J. Cell Biol. 2007)
    9. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)1, 2 Li H.H.... Liu X. (EMBO J. 2007)
    10. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5515 HGNC: 9299 AceView: PPP2CA Ensembl:ENSG00000113575 euGenes: HUgn5515
    ECgene: PPP2CA Kegg: 5515 H-InvDB: PPP2CA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPP2CA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2CA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPP2CA gene:
    Search GeneIP for patents involving PPP2CA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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