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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP2CA Gene

protein-coding   GIFtS: 68
GCID: GC05M133530

protein phosphatase 2, catalytic subunit, alpha isozyme

(Previous names: protein phosphatase 2 (formerly 2A), catalytic subunit,...)
 Explore 29 diseases affiliated with
PPP2CA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPP2CA    

Aliases
for PPP2CA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme1 2     EC 3.1.3.163 8
PP2Calpha1 2     PP2Ac2
Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform1 2     PP2CA2
Replication Protein C2 3     Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform2
PP2A-Alpha1     Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform2
RP-C2 3     Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Alpha Isoform2

External Ids:    HGNC: 92991   Entrez Gene: 55152   Ensembl: ENSG000001135757   OMIM: 1769155   UniProtKB: P677753   

Export aliases for PPP2CA gene to outside databases

Previous GC identifers: GC05M133180 GC05M134046 GC05M133563 GC05M133608 GC05M133560 GC05M128717


Summaries
for PPP2CA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPP2CA:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr
phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common
heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates
with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PP2AA_HUMAN, P67775
Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of
phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to
protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity).
Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'

summary for PPP2CA:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for PPP2CA


Genomic Views
for PPP2CA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP2CA gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   STAT1alpha   Arnt   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPP2CA promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP2CA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP2CA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

PPP2CA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP2CA gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M133530:  view genomic region     (about GC identifiers)

Start:
 133,530,025 bp from pter      End:
 133,561,950 bp from pter
Size:
 31,926 bases      Orientation:
 minus strand

Proteins
for PPP2CA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PP2AA_HUMAN, P67775 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform  
Size: 309 amino acids; 35594 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Subunit: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C)
and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory
subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the
R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins,
and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity). Interacts with TP53,
SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction
promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with
IGBP1 protects unassembled PPP2CA from degradative ubiquitination
Subcellular location: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In
prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
Centromeric localization requires the presence of SGOL2 (By similarity)
6/12 PDB 3D structures from and Proteopedia for PPP2CA (see all 12):
2IAE (3D)        2IE3 (3D)        2IE4 (3D)        2NPP (3D)        2NYL (3D)        2NYM (3D)    
Secondary accessions: P05323 P13197
Alternative splicing: 2 isoforms:  P67775-1   P67775-2   (Catalytically inactive, shows enhanced binding to IGBP1, and does not interact with the scaffolding subunit PPP2R1A)

Explore the universe of human proteins at neXtProt for PPP2CA: NX_P67775

Post-translational modifications:

  • Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly, enhancing the
    • affinity of the PP2A core enzyme for some, but not all, regulatory subunits. It varies during the cell cycle1
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in
    • inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P67775

    • 4/26 DME Specific Peptides for PPP2CA (P67775) (see all 26)
     NYLFMGD  QLSESQV  QEVPHEG  ELFRIGG 

    PPP2CA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002706.1  
    ENSEMBL proteins: 
     ENSP00000418447   ENSP00000430869   ENSP00000428816  
    Reactome Protein details: P67775
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: PPP2CA
    OriGene Protein Over-expression Lysate: PPP2CA
    OriGene Custom Protein Services for PPP2CA 
    GenScript Custom Purified and Recombinant Proteins Services for PPP2CA
    Novus Biologicals PPP2CA Protein
    Novus Biologicals PPP2CA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159protein phosphatase type 2A complex TAS11007961
    GO:0000775chromosome, centromeric region IEA--
    GO:0000922spindle pole IEA--
    GO:0005634nucleus NAS11007961
    GO:0005737cytoplasm ----


    PPP2CA for ontologies           About GeneDecksing



    PPP2CA Antibody Products: 
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    ThermoFisher Antibody for PPP2CA

    Assay Products for PPP2CA: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PPP2CA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPP2CA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004843 Metallo_PEstase_dom
     IPR006186 Ser/Thr-sp_prot-phosphatase

    Graphical View of Domain Structure for InterPro Entry P67775

    ProtoNet protein and cluster: P67775

    1 Blocks protein family: IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

    UniProtKB/Swiss-Prot: PP2AA_HUMAN, P67775
    Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily


    Function
    for PPP2CA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PP2AA_HUMAN, P67775
    Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of
    phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to
    protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity).
    Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for PPP2CA:
    protein phosphatase 2A,catalytic subunit,alpha isoform,antagonizing cdc2/CCNB1 complex which regulates the G2-M
    transition in the cell cycle

    Enzyme Number (IUBMB): EC 3.1.3.161 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP2CA
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP2CA (see all 67):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-106a hsa-miR-200a hsa-miR-550a* hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: PPP2CA 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of PPP2CA Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP2CA (see all 7)
    OriGene shRNA RFP: PPP2CA
    OriGene siRNA: PPP2CA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP2CA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PPP2CA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CA (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP2CA (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPP2CA (NM_002715)
    Sino Biological Human cDNA Clone for PPP2CA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP2CA 

    Cell Line
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    Search LifeMap BioReagents cell lines for PPP2CA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP2CA

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008022protein C-terminus binding IEA--
    GO:0046872metal ion binding IEA--


    PPP2CA for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PPP2CA:
     Decreased focal adhesion (FA)   Increased apoptosis  Increased cell number in S and  Increased mitotic exit time 
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for PPP2CA: Ppp2catm1.2Nju Ppp2catm1Gotz
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ppp2ca):
     cardiovascular system  embryogenesis  growth/size  hematopoietic system  integument 
     liver/biliary system  mortality/aging  normal 

    PPP2CA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPP2CA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/82 super-pathways (see all 82) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2ERK/MAPK targets
    		ERK/MAPK targets1.00
    		ERKs are inactivated0.57
    		Nuclear Events (kinase and transcription factor activation)0.88
    		PP2A-mediated dephosphorylation of key metabolic factors0.22
    		MAPK targets/ Nuclear events mediated by MAP kinases0.70
    		MASTL Facilitates Mitotic Progression0.15
    3M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    4Signaling by FGFR
    		Signaling by FGFR1.00
    		NGF signalling via TRKA from the plasma membrane0.70
    		Signaling by FGFR in disease0.91
    		Signalling by NGF0.52
    5Cyclins and Cell Cycle Regulation
    		Cyclins and Cell Cycle Regulation1.00
    		Cyclin D associated events in G10.32
    		Cell Cycle Control by BTG Proteins0.36
    		G1 Phase0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/11 EMD Millipore Pathways for PPP2CA (see all 11)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Calcium signaling
    Development Beta-adrenergic receptors signaling via cAMP
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Start of DNA replication in early S phase

    1 R&D Systems Pathway for PPP2CA
        TGF-beta Signaling Pathways

    5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP2CA (see all 24)
        Cell Cycle Control by BTG Proteins
    CDK5 Pathway
    mTOR Pathway
    AMPK Enzyme Complex Pathway
    Cyclins and Cell Cycle Regulation

    3 Cell Signaling Technology (CST) Pathways for PPP2CA
        Phosphatases
    MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    5 Tocris Bioscience Pathways for PPP2CA
        Akt Pathway
    Insulin Pathway
    TGF-beta Pathway
    mTOR Pathway
    Wnt Pathway

    5/12 GeneGo (Thomson Reuters) Pathways for PPP2CA (see all 12)
        Apoptosis and survival BAD phosphorylation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction AKT signaling
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/13 BioSystems Pathways for PPP2CA (see all 13) 
        Wnt Signaling Pathway and Pluripotency
    Glycogen Metabolism
    TNF-alpha/NF-kB Signaling Pathway
    IL-6 Signaling Pathway
    IL-3 Signaling Pathway

    5/80        Reactome Pathways for PPP2CA (see all 80)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Platelet homeostasis
    Toll Like Receptor 3 (TLR3) Cascade
    MyD88-independent cascade

    1 PharmGKB Pathway for PPP2CA
        Diuretics Pathway, Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for PPP2CA) (see all 8):
        mRNA surveillance pathway
    Oocyte meiosis
    Wnt signaling pathway
    TGF-beta signaling pathway
    Tight junction


    PPP2CA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP2CA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/298 Interacting proteins for PPP2CA (P677751, 2, 3 ENSP000004184474) via UniProtKB, MINT, STRING, and/or I2D (see all 298)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1BP301541, 2, 3, ENSP000003113444EBI-712311,EBI-2559603 MINT-8287178 I2D: score=5 STRING: ENSP00000311344
    RELAQ042062, 3, ENSP000003842734MINT-8208073 MINT-8206588 MINT-8207858 MINT-8208045 MINT-8207553 MINT-8313257 I2D: score=4 STRING: ENSP00000384273
    GSK3BP498412, 3, ENSP000003248064MINT-7025816 MINT-7025684 MINT-7025707 MINT-8288062 I2D: score=1 STRING: ENSP00000324806
    AXIN1O151692, 3, ENSP000002623204MINT-7025816 MINT-7025684 MINT-7025707 I2D: score=5 STRING: ENSP00000262320
    PPP2R5BQ151732, 3, ENSP000001641334MINT-2835561 MINT-8287055 MINT-8287075 I2D: score=5 STRING: ENSP00000164133
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000188inactivation of MAPK activity NAS11007961
    GO:0001932regulation of protein phosphorylation ----
    GO:0006275regulation of DNA replication NAS11007961
    GO:0006355regulation of transcription, DNA-dependent NAS11007961


    PPP2CA for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPP2CA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPP2CA for compounds           About GeneDecksing

    EMD Millipore small molecules for PPP2CA:
    Small Molecule - inhibitor
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    Compounds for PPP2CA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CantharidinProtein phosphatase 1 and 2A inhibitor[56-25-7]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]
    Fostriecin sodium saltPotent PP2A and PP4 inhibitor[87860-39-7]

    6 HMDB Compounds for PPP2CA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for PPP2CA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 17016423
    (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-- --target--10592235
    2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid-- --target--10592235

    5 Novoseek chemical compound relationships for PPP2CA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 70 2 10191253 (1), 10026142 (1)
    okadaic acid 60 1 8529028 (1)
    serine 59.7 2 10191253 (1), 10026142 (1)
    leucine 48.7 6 10191253 (2), 9877231 (1), 17662254 (1), 8206937 (1) (see all 5)
    glucose 0 13 14970009 (5), 9877231 (1)

    Search CenterWatch for drugs/clinical trials and news about PPP2CA / PP2AA 

    Transcripts
    for PPP2CA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPP2CA gene: 
    NM_002715.2  

    Unigene Cluster for PPP2CA:

    Protein phosphatase 2, catalytic subunit, alpha isozyme
    Hs.105818  [show with all ESTs]
    Unigene Representative Sequence: BX640662
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481195(uc003kze.3) ENST00000472253 ENST00000495833 ENST00000522385
    ENST00000523082 ENST00000231504

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB451240.1 AB451365.1 AK057424.1 AK097599.1 BC000400.2 BC002657.2 BC019275.1 BC031696.1 
    BX640662.1 CR457417.1 

    24/40 DOTS entries (see all 40):

    DT.70104269  DT.95165446  DT.97776346  DT.100672537  DT.97773863  DT.101986353  DT.120801791  DT.100672543 
    DT.305787  DT.100013274  DT.120801594  DT.91781757  DT.95101683  DT.423150  DT.86998477  DT.100038352 
    DT.99963260  DT.100652923  DT.120801881  DT.91781763  DT.100672539  DT.120801728  DT.120801815  DT.87079217 

    24/636 AceView cDNA sequences (see all 636):

    BE504360 BQ636455 BU506792 BM750469 AU119207 BM985169 BM717443 F05133 
    AA468852 F13255 BE464559 AI075233 F11574 BQ267857 AA665870 BU786119 
    CB148946 BQ719567 BQ016756 BM723788 BI461208 CB068621 BU861163 F06808 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CA (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -     -                 -     -                             -                     
    SP2:                                                                                                            
    SP3:                          -     -                 -     -                                                   
    SP4:                          -     -           -     -     -                                                   
    SP5:                                -                 -     -                                                   


    ECgene alternative splicing isoforms for PPP2CA

    Expression
    for PPP2CA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP2CA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTTCTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PPP2CA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP2CA

    SOURCE GeneReport for Unigene cluster: Hs.105818
        SABiosciences Expression via Pathway-Focused PCR Arrays including PPP2CA (see all 6): 
              mTOR Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Orthologs
    for PPP2CA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP2CA gene from 10/38 species (see all 38)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ppp2ca1 , 5 protein phosphatase 2 (formerly 2A), catalytic subunit, more1, 5 94.28(n)1
    99.68(a)1    		   11 (31.86 cM)5
    190521  NM_019411.41  NP_062284.11 
     520986815 
    chicken
    (Gallus gallus)    		 Aves PPP2CA1 protein phosphatase 2, catalytic subunit, alpha isozyme 88.67(n)
    99.03(a)    		   416318  NM_001006152.1  NP_001006152.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PPP2CA6
    		 --
    		 99(a)
    		 1 ↔ 1
    		 2(130846845-130864272)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ppp2ca-prov2 protein phosphatase 2 (formerly 2A), catalytic subunit, more 83.06(n)    BC042272.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:560641 zgc:56064 79.94(n)
    97.09(a)    		   393885  NM_200911.1  NP_957205.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mts3 R7 cell fate commitment protein phosphatase
    type more    		 93(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea F38H4.93 serine/threonine protein phosphatase 89(a)
    (best of 15)    		   IV(11858618-11859876)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PPH221 Pph22p 66(n)
    76.41(a)    		   851339   NP_010093.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PP2A-11 serine/threonine-protein phosphatase PP2A-1 catalytic more 70.65(n)
    80.4(a)    		   842276  NM_104676.4  NP_176192.1 
    rice
    (Oryza sativa)    		 Liliopsida AK099604.12   -- 75.16(n)    AK099604.1 


    ENSEMBL Gene Tree for PPP2CA (if available)
    TreeFam Gene Tree for PPP2CA (if available) 

    Paralogs
    for PPP2CA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP2CA gene
    PPP2CB2  PPP4C2  
    10 SIMAP similar genes for PPP2CA using alignment to 5 protein entries:     PP2AA_HUMAN (see all proteins):
    PPP2CB    PPP4C    PPP6C    PPP1CB    PPP1CC    PPP1CA
    PPP5C    PPP3CA    PPP3CC    PPP3CB

    PPP2CA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPP2CA
    PGOHUM00000243980


    Genomic Variants
    for PPP2CA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/557 NCBI SNPs in PPP2CA are shown (see all 557)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs781244101,2
    		C,--133531695(+) TATTTG/TTTCAG 1 -- ds50010--------
    rs1806926911,2
    		--133531702(+) TCAGTC/TGGAGA 1 -- ds50010--------
    rs1852702591,2
    		--133531712(+) AGAAAA/GGGCAT 1 -- ds50010--------
    rs1420575301,2
    		--133531819(+) GCTTTC/GGAAAA 1 -- ds50010--------
    rs2019065901,2
    		C--133531820(+) CTTTGA/GAAAAT 1 -- ds50010--------
    rs1904235951,2
    		--133531863(+) TAGATC/TAGAAA 1 -- ds50010--------
    rs1811803281,2
    		--133532029(+) TAAAAC/TATCAA 1 -- ds50010--------
    rs1446571011,2
    		--133532162(+) TGTACA/GTAAGA 1 -- ut310--------
    rs1869088391,2
    		--133532199(+) CTATTC/TGGTTT 1 -- ut310--------
    rs10524691,2
    		C,H--133532454(-) GGGTTT/GTGTTT 1 -- ut312Minor allele frequency- G:0.00MN NS 360

    HapMap Linkage Disequilibrium report for PPP2CA (133530025 - 133561950 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PPP2CA: --

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    Disorders / Diseases
    for PPP2CA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPP2CA for disorders           About GeneDecksing

    OMIM gene information: 176915    OMIM disorders: --

    20/29 diseases for PPP2CA (see all 29):    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    adenomatous polyposis coli
    wilms tumor    chagas disease    polyposis    down syndrome
    hepatitis c    trypanosomiasis    cerebritis    lung adenocarcinoma
    ovarian carcinoma    alzheimer's disease    retinoblastoma    adenocarcinoma
    prostate cancer    breast cancer    hepatitis    fibrosis

    Human Genome Epidemiology (HuGE) Navigator: PPP2CA (3 documents)

    Export disorders for PPP2CA gene to outside databases

    Publications
    for PPP2CA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP2CA gene, integrated from 9 sources (see all 220):
    (articles sorted by number of sources associating them with PPP2CA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. (PubMed id 10191253)1, 2, 9 Bryant J.C.... Wadzinski B.E. (1999)
    2. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PubMed id 8206937)1, 2, 9 Favre B.... Hemmings B.A. (1994)
    3. Identification and characterization of an alternativel y spliced isoform of the human protein phosphatase 2Aa catalytic subunit. (PubMed id 22167190)1, 2 Migueleti D.L....Zanchin N.I. (2012)
    4. Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation. (PubMed id 22613722)1, 2 Watkins G.R.... Wadzinski B.E. (2012)
    5. Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. (PubMed id 20092282)1, 2 McConnell J.L....Wadzinski B.E. (2010)
    6. Alpha4 is an essential regulator of PP2A phosphatase activity. (PubMed id 19818709)1, 2 Kong M....Thompson C.B. (2009)
    7. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. (PubMed id 17485487)1, 2 Huang H....Yen T.J. (2007)
    8. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage- induced dephosphorylation of p53 at Thr55. (PubMed id 17245430)1, 2 Li H.H.... Liu X. (2007)
    9. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (2006)
    10. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (PubMed id 16580887)1, 2 Tang Z....Yu H. (2006)

    External Searches for PPP2CA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPP2CA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5515 HGNC: 9299 AceView: PPP2CA Ensembl:ENSG00000113575 euGenes: HUgn5515
    ECgene: PPP2CA Kegg: 5515 H-InvDB: PPP2CA

    Other Databases showing PPP2CA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPP2CA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP2CA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP2CA Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PPP2CA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPP2CA gene:
    Search GeneIP for patents involving PPP2CA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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