Aliases for PPP2CA Gene
- Protein Phosphatase 2 Catalytic Subunit Alpha 2 3
- Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme 2 3 5
- Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform 2 3
- Replication Protein C 3 4
- EC 22.214.171.124 4 63
- PP2A-Alpha 3 4
- RP-C 3 4
- Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform 3
External Ids for PPP2CA Gene
Previous GeneCards Identifiers for PPP2CA Gene
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2CA Gene
PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha) is a Protein Coding gene. Among its related pathways are Negative regulation of MAPK pathway and p70S6K Signaling. GO annotations related to this gene include hydrolase activity and protein C-terminus binding. An important paralog of this gene is PPP4C.
UniProtKB/Swiss-Prot for PPP2CA Gene
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.