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Aliases for PPP2CA Gene

Aliases for PPP2CA Gene

  • Protein Phosphatase 2 Catalytic Subunit Alpha 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform 2 3
  • Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme 2 3
  • Replication Protein C 3 4
  • EC 3.1.3.16 4 61
  • PP2A-Alpha 3 4
  • RP-C 3 4
  • Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Alpha Isoform 3
  • Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform 2
  • PP2Calpha 3
  • PP2CA 3
  • PP2Ac 3

External Ids for PPP2CA Gene

Previous GeneCards Identifiers for PPP2CA Gene

  • GC05M133180
  • GC05M134046
  • GC05M133563
  • GC05M133608
  • GC05M133560
  • GC05M128717
  • GC05M133530

Summaries for PPP2CA Gene

Entrez Gene Summary for PPP2CA Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2CA Gene

PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP2CA include Usher Syndrome, Type 1C. Among its related pathways are Development IGF-1 receptor signaling and mTOR Pathway. GO annotations related to this gene include hydrolase activity and protein C-terminus binding. An important paralog of this gene is PPP2CB.

UniProtKB/Swiss-Prot for PPP2CA Gene

  • PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.

Tocris Summary for PPP2CA Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2CA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CA Gene

Genomics for PPP2CA Gene

Regulatory Elements for PPP2CA Gene

Enhancers for PPP2CA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G134546 2 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -325.8 -325801 10.1 HDGF PKNOX1 ARNT SIN3A YBX1 ZBTB7B ZNF766 ZNF143 ZNF207 FOS CAMLG PPP2CA JADE2 SEC24A UBE2B TXNDC15 CDKL3 TCF7 GC05M134520 GC05M134578
GH05G134289 0.9 ENCODE 11.1 -63.4 -63446 0.1 RB1 ARID4B ZNF2 THRB RAD21 RFX5 ZNF143 MIXL1 DEK ZNF654 SKP1 JADE2 PPP2CA ENSG00000248559 CDKN2AIPNL RPS10P11 DDX46 GC05P134270 ENSG00000273345
GH05G133976 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +248.2 248222 2.1 SOX13 SAP130 ZFP64 JUNB HMG20A GLIS1 EED IKZF1 SCRT2 FOS VDAC1 PPP2CA UBE2B C5orf15 GC05P134006
GH05G134275 0.8 ENCODE 12 -49.7 -49726 0.2 SUZ12 ZNF335 GLIS2 ZBTB48 SCRT2 PATZ1 ZBTB20 EZH2 ZNF263 ZBTB10 PPP2CA SKP1 ENSG00000248559 GC05P134270 ENSG00000273345
GH05G134223 1.4 ENCODE dbSUPER 6.6 +0.2 201 5.0 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF207 SKP1 PPP2CA MIR3661 ENSG00000272772
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP2CA on UCSC Golden Path with GeneCards custom track

Promoters for PPP2CA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187056 859 3201 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF207

Genomic Location for PPP2CA Gene

Chromosome:
5
Start:
134,194,334 bp from pter
End:
134,226,259 bp from pter
Size:
31,926 bases
Orientation:
Minus strand

Genomic View for PPP2CA Gene

Genes around PPP2CA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2CA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CA Gene

Proteins for PPP2CA Gene

  • Protein details for PPP2CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67775-PP2AA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Protein Accession:
    P67775
    Secondary Accessions:
    • P05323
    • P13197

    Protein attributes for PPP2CA Gene

    Size:
    309 amino acids
    Molecular mass:
    35594 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity). Interacts with TP53, SGO1 and SGO2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination. Interacts with GSK3B (via C2 domain).

    Three dimensional structures from OCA and Proteopedia for PPP2CA Gene

    Alternative splice isoforms for PPP2CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2CA Gene

Selected DME Specific Peptides for PPP2CA Gene

P67775:
  • FCLHGGLSP
  • LCEKAKEIL
  • DLLWSDP
  • YGFYDEC
  • RAHQLVMEG
  • PAPRRGEP
  • FTKELDQW
  • PDTNYLF
  • SAPNYCYRC
  • LLVALKVRY
  • NYLFMGD
  • TIFSAPNY
  • FLQFDPAPR
  • SVETVTLLV
  • HGQFHDL
  • RGNHESRQ
  • QEVPHEG
  • ELFRIGG
  • GDYVDRG
  • GWGISPRGAG
  • QLSESQV
  • FTDLFDYLPLTAL
  • SPRGAGYTFG
  • CGDVHGQ
  • LDQWIEQLNEC
  • CPVTVCGD

Post-translational modifications for PPP2CA Gene

  • May be monoubiquitinated by NOSIP.
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
  • Ubiquitination at Lys4, posLast=88, posLast=2121, and Lys29
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CA Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPP2CA Gene

Graphical View of Domain Structure for InterPro Entry

P67775

UniProtKB/Swiss-Prot:

PP2AA_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CA: view

Function for PPP2CA Gene

Molecular function for PPP2CA Gene

GENATLAS Biochemistry:
protein phosphatase 2A,catalytic subunit,alpha isoform,antagonizing cdc2/CCNB1 complex which regulates the G2-M transition in the cell cycle
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.

Enzyme Numbers (IUBMB) for PPP2CA Gene

Gene Ontology (GO) - Molecular Function for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 1328865
GO:0008022 protein C-terminus binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP2CA: view
genes like me logo Genes that share phenotypes with PPP2CA: view

Animal Models for PPP2CA Gene

MGI Knock Outs for PPP2CA:

Animal Model Products

CRISPR Products

miRNA for PPP2CA Gene

miRTarBase miRNAs that target PPP2CA

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CA Gene

Localization for PPP2CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CA Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGO2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2CA gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex TAS 11007961
GO:0000775 chromosome, centromeric region IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus NAS 11007961
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PPP2CA: view

Pathways & Interactions for PPP2CA Gene

SuperPathways for PPP2CA Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 S45 mutants of beta-catenin arent phosphorylated
4 Negative regulation of FGFR1 signaling
5 GAB1 signalosome
genes like me logo Genes that share pathways with PPP2CA: view

Pathways by source for PPP2CA Gene

SIGNOR curated interactions for PPP2CA Gene

Gene Ontology (GO) - Biological Process for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000188 inactivation of MAPK activity NAS 11007961
GO:0006275 regulation of DNA replication NAS 11007961
GO:0006355 regulation of transcription, DNA-templated NAS 11007961
GO:0006470 protein dephosphorylation IEA,TAS 2849764
genes like me logo Genes that share ontologies with PPP2CA: view

Drugs & Compounds for PPP2CA Gene

(20) Drugs for PPP2CA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 414,411
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922

(3) Additional Compounds for PPP2CA Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
FK 506
104987-11-3

(5) Tocris Compounds for PPP2CA Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
Tautomycetin Selective PP1 inhibitor 119757-73-2

(4) ApexBio Compounds for PPP2CA Gene

Compound Action Cas Number
Ceramide Protein phosphatase and CAPP modulator 3102-57-6
DL-AP3 Glutamate receptor antagonist and HPSP inhibitor 20263-06-3
Microcystin-LR Inhibitor of protein phosphatase PP1/PP2A,potent and selective 101043-37-2
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP2CA: view

Transcripts for PPP2CA Gene

Unigene Clusters for PPP2CA Gene

Protein phosphatase 2, catalytic subunit, alpha isozyme:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -

Relevant External Links for PPP2CA Gene

GeneLoc Exon Structure for
PPP2CA
ECgene alternative splicing isoforms for
PPP2CA

Expression for PPP2CA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2CA Gene

Protein differential expression in normal tissues from HIPED for PPP2CA Gene

This gene is overexpressed in Cervix (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP2CA Gene



Protein tissue co-expression partners for PPP2CA Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP2CA Gene:

PPP2CA

SOURCE GeneReport for Unigene cluster for PPP2CA Gene:

Hs.105818

Evidence on tissue expression from TISSUES for PPP2CA Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Liver(4.5)
  • Kidney(3.5)
  • Pancreas(3.1)
  • Intestine(3)
  • Muscle(2.4)
  • Heart(2.2)
  • Blood(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with PPP2CA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2CA Gene

Orthologs for PPP2CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CA Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PPP2CA 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP2CA 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia PPP2CA 34 35
  • 96.87 (n)
dog
(Canis familiaris)
Mammalia PPP2CA 34
  • 96.44 (n)
rat
(Rattus norvegicus)
Mammalia Ppp2ca 34
  • 94.39 (n)
mouse
(Mus musculus)
Mammalia Ppp2ca 34 16 35
  • 94.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2CA 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2CA 34 35
  • 88.67 (n)
lizard
(Anolis carolinensis)
Reptilia PPP2CA 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2ca 34
  • 85.11 (n)
MGC75638 34
African clawed frog
(Xenopus laevis)
Amphibia ppp2ca-prov 34
zebrafish
(Danio rerio)
Actinopterygii ppp2ca 35
  • 97 (a)
OneToOne
zgc:56064 34
  • 79.94 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10181 34
fruit fly
(Drosophila melanogaster)
Insecta mts 36 34 35
  • 73.03 (n)
CG11597 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010172 34
  • 72.71 (n)
worm
(Caenorhabditis elegans)
Secernentea F38H4.9 36
  • 89 (a)
let-92 34 35
  • 73.4 (n)
pph-4.1 36
  • 62 (a)
pph-4.2 36
  • 62 (a)
C34C12.3 36
  • 52 (a)
C25A6.1 36
  • 43 (a)
C06A1.3 36
  • 41 (a)
W03D8.2 36
  • 40 (a)
C24H11.1 36
  • 38 (a)
C24H11.2 36
  • 38 (a)
Y40H4A.2 36
  • 38 (a)
F58G1.3 36
  • 36 (a)
R13A5.11 36
  • 36 (a)
F42G8.8 36
  • 34 (a)
C27B7.6 36
  • 32 (a)
F49E11.7 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH21 35
  • 62 (a)
ManyToMany
PPH22 35
  • 61 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PP2A-1 34
  • 70.65 (n)
soybean
(Glycine max)
eudicotyledons Gma.10697 34
rice
(Oryza sativa)
Liliopsida Os06g0574500 34
  • 70.21 (n)
corn
(Zea mays)
Liliopsida Zm.9014 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11024 35
  • 92 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa1 34
  • 70.65 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5327 34
Species where no ortholog for PPP2CA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2CA Gene

ENSEMBL:
Gene Tree for PPP2CA (if available)
TreeFam:
Gene Tree for PPP2CA (if available)

Paralogs for PPP2CA Gene

Paralogs for PPP2CA Gene

(11) SIMAP similar genes for PPP2CA Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PPP2CA Gene

genes like me logo Genes that share paralogs with PPP2CA: view

Variants for PPP2CA Gene

Sequence variations from dbSNP and Humsavar for PPP2CA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs148071386 Uncertain significance 134,200,433(+) TCCTC(A/G)AGGAG reference, stop-gained
rs864622012 Uncertain significance 134,197,778(-) ACTAC(-/TTC)CTGTA cds-indel
rs1000046540 -- 134,209,394(+) GTCTC(A/T)ACTTA intron-variant
rs1000058427 -- 134,213,889(+) CTTTG(A/G)GAGCC intron-variant
rs1000151518 -- 134,216,559(+) AAAAG(G/T)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2CA Gene

Variant ID Type Subtype PubMed ID
nsv599732 CNV loss 21841781

Variation tolerance for PPP2CA Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP2CA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2CA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CA Gene

Disorders for PPP2CA Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP2CA Gene - From: DISEASES

Disorder Aliases PubMed IDs
usher syndrome, type 1c
  • usher syndrome type 1c
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP2CA

Genetic Association Database (GAD)
PPP2CA
Human Genome Epidemiology (HuGE) Navigator
PPP2CA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP2CA
genes like me logo Genes that share disorders with PPP2CA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2CA Gene

Publications for PPP2CA Gene

  1. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. (PMID: 10191253) Bryant J.C. … Wadzinski B.E. (Biochem. J. 1999) 3 4 22 64
  2. The catalytic subunit of protein phosphatase 2A is carboxyl- methylated in vivo. (PMID: 8206937) Favre B. … Hemmings B.A. (J. Biol. Chem. 1994) 3 4 22 64
  3. Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit. (PMID: 22167190) Migueleti D.L. … Zanchin N.I. (J. Biol. Chem. 2012) 3 4 64
  4. Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation. (PMID: 22613722) Watkins G.R. … Wadzinski B.E. (J. Biol. Chem. 2012) 3 4 64
  5. Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. (PMID: 20092282) McConnell J.L. … Wadzinski B.E. (Biochemistry 2010) 3 4 64

Products for PPP2CA Gene

Sources for PPP2CA Gene