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Aliases for PPP1R9B Gene

Aliases for PPP1R9B Gene

  • Protein Phosphatase 1, Regulatory Subunit 9B 2 3
  • Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin 2 3
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9B 2 3
  • Spinophilin 2 4
  • Neurabin-II 3 4
  • Neurabin-2 2 3
  • PPP1R6 3 4
  • Protein Phosphatase 1 Regulatory Subunit 9B 4
  • PPP1R9 3
  • SPINO 3
  • SPN 3

External Ids for PPP1R9B Gene

Previous HGNC Symbols for PPP1R9B Gene

  • PPP1R6
  • PPP1R9

Previous GeneCards Identifiers for PPP1R9B Gene

  • GC17U990076
  • GC17M050692
  • GC17M048553
  • GC17M048687
  • GC17M048685
  • GC17M045567
  • GC17M048211
  • GC17M043579

Summaries for PPP1R9B Gene

Entrez Gene Summary for PPP1R9B Gene

  • This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

GeneCards Summary for PPP1R9B Gene

PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B) is a Protein Coding gene. Diseases associated with PPP1R9B include limbic encephalitis and schizophrenia. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include actin binding and protein phosphatase 1 binding. An important paralog of this gene is PPP1R9A.

UniProtKB/Swiss-Prot for PPP1R9B Gene

  • Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.

Gene Wiki entry for PPP1R9B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R9B Gene

Genomics for PPP1R9B Gene

Regulatory Elements for PPP1R9B Gene

Genomic Location for PPP1R9B Gene

Start:
50,133,735 bp from pter
End:
50,150,630 bp from pter
Size:
16,896 bases
Orientation:
Minus strand

Genomic View for PPP1R9B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R9B Gene

Proteins for PPP1R9B Gene

  • Protein details for PPP1R9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SB3-NEB2_HUMAN
    Recommended name:
    Neurabin-2
    Protein Accession:
    Q96SB3
    Secondary Accessions:
    • Q8TCR9

    Protein attributes for PPP1R9B Gene

    Size:
    815 amino acids
    Molecular mass:
    89192 Da
    Quaternary structure:
    • Interacts with DCLK2 (By similarity). Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, PPP1CA, neurabin-1, TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4, RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1 and TIAM1. Interacts (via C-terminus) with SPATA13 (via C-terminal tail).

neXtProt entry for PPP1R9B Gene

Proteomics data for PPP1R9B Gene at MOPED

Post-translational modifications for PPP1R9B Gene

  • Stimulation of D1 (but not D2) dopamine receptors induces Ser-94 phosphorylation. Dephosphorylation of Ser-94 is mediated mainly by PP1 and to a lesser extent by PP2A. Phosphorylation of spinophilin disrupts its association with F-actin, but does not affect its binding to PP1 (By similarity).
  • Ubiquitination at Lys675 and Lys687
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1R9B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP1R9B (Spinophilin)

No data available for DME Specific Peptides for PPP1R9B Gene

Domains for PPP1R9B Gene

Gene Families for PPP1R9B Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for PPP1R9B Gene

Graphical View of Domain Structure for InterPro Entry

Q96SB3

UniProtKB/Swiss-Prot:

NEB2_HUMAN :
  • Q96SB3
Domain:
  • The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with PPP1R9B: view

Function for PPP1R9B Gene

Molecular function for PPP1R9B Gene

UniProtKB/Swiss-Prot Function:
Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.

Gene Ontology (GO) - Molecular Function for PPP1R9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004864 protein phosphatase inhibitor activity NAS 11278317
GO:0005515 protein binding IPI 11278317
GO:0008157 protein phosphatase 1 binding NAS 11278317
genes like me logo Genes that share ontologies with PPP1R9B: view
genes like me logo Genes that share phenotypes with PPP1R9B: view

Animal Models for PPP1R9B Gene

MGI Knock Outs for PPP1R9B:

Animal Model Products

miRNA for PPP1R9B Gene

miRTarBase miRNAs that target PPP1R9B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R9B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPP1R9B Gene

Localization for PPP1R9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R9B Gene

Cytoplasm, cytoskeleton. Nucleus. Cell projection, dendritic spine. Cell junction, synapse. Cell junction, adherens junction. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R9B Gene COMPARTMENTS Subcellular localization image for PPP1R9B gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for PPP1R9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex TAS 11278317
GO:0005654 nucleoplasm IMP 11278317
GO:0005737 cytoplasm IDA 11278317
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA 19151759
genes like me logo Genes that share ontologies with PPP1R9B: view

Pathways for PPP1R9B Gene

genes like me logo Genes that share pathways with PPP1R9B: view

Pathways by source for PPP1R9B Gene

1 Tocris pathway for PPP1R9B Gene

Gene Ontology (GO) - Biological Process for PPP1R9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001560 regulation of cell growth by extracellular stimulus TAS 11278317
GO:0001932 regulation of protein phosphorylation --
GO:0007015 actin filament organization --
GO:0007050 cell cycle arrest TAS 11278317
GO:0007096 regulation of exit from mitosis NAS 11278317
genes like me logo Genes that share ontologies with PPP1R9B: view

Compounds for PPP1R9B Gene

(4) Novoseek inferred chemical compound relationships for PPP1R9B Gene

Compound -log(P) Hits PubMed IDs
letrozole 63.8 6
dopamine 37.5 4
glutamate 33.3 7
estradiol 28.7 2
genes like me logo Genes that share compounds with PPP1R9B: view

Transcripts for PPP1R9B Gene

mRNA/cDNA for PPP1R9B Gene

Unigene Clusters for PPP1R9B Gene

Protein phosphatase 1, regulatory subunit 9B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPP1R9B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R9B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for PPP1R9B Gene

GeneLoc Exon Structure for
PPP1R9B
ECgene alternative splicing isoforms for
PPP1R9B

Expression for PPP1R9B Gene

mRNA expression in normal human tissues for PPP1R9B Gene

Protein differential expression in normal tissues for PPP1R9B Gene

This gene is overexpressed in Brain (10.4) and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PPP1R9B Gene

SOURCE GeneReport for Unigene cluster for PPP1R9B Gene Hs.514323

genes like me logo Genes that share expressions with PPP1R9B: view

Expression partners for PPP1R9B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPP1R9B Gene

Orthologs for PPP1R9B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R9B 35
  • 92.33 (n)
  • 95.61 (a)
dog
(Canis familiaris)
Mammalia PPP1R9B 35
  • 92.08 (n)
  • 95.35 (a)
PPP1R9B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r9b 35
  • 90.48 (n)
  • 96.08 (a)
Ppp1r9b 16
Ppp1r9b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPP1R9B 35
  • 98.93 (n)
  • 98.72 (a)
rat
(Rattus norvegicus)
Mammalia Ppp1r9b 35
  • 89.71 (n)
  • 95.22 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1R9B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R9B 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia PPP1R9B 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r9b 35
  • 65.58 (n)
  • 70.2 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14045 35
LOC558232 35
  • 73.62 (n)
  • 76.13 (a)
ppp1r9b 36
  • 63 (a)
OneToMany
PPP1R9B (1 of 2) 36
  • 62 (a)
OneToMany
Species with no ortholog for PPP1R9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R9B Gene

ENSEMBL:
Gene Tree for PPP1R9B (if available)
TreeFam:
Gene Tree for PPP1R9B (if available)

Paralogs for PPP1R9B Gene

Paralogs for PPP1R9B Gene

Selected SIMAP similar genes for PPP1R9B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPP1R9B: view

Variants for PPP1R9B Gene

Sequence variations from dbSNP and Humsavar for PPP1R9B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11365 -- 50,134,169(+) GGAGG(G/T)GGTCT utr-variant-3-prime
rs12111 -- 50,134,115(+) CAGGG(A/G)CATGA utr-variant-3-prime
rs847680 -- 50,146,710(-) GTGCA(A/G)TGGAC intron-variant
rs847687 -- 50,152,080(+) GTTCA(G/T)TCCAC upstream-variant-2KB
rs847688 -- 50,151,620(-) GCTGG(A/G)CCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP1R9B Gene

Variant ID Type Subtype PubMed ID
nsv908588 CNV Loss 21882294
dgv3225n71 CNV Loss 21882294
dgv3226n71 CNV Loss 21882294
nsv828038 CNV Gain 20364138

Relevant External Links for PPP1R9B Gene

HapMap Linkage Disequilibrium report
PPP1R9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R9B Gene

Disorders for PPP1R9B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPP1R9B Gene in MalaCards »

(2) Diseases for PPP1R9B Gene including...

(2) University of Copenhagen DISEASES for PPP1R9B Gene

(5) Novoseek inferred disease relationships for PPP1R9B Gene

Disease -log(P) Hits PubMed IDs
calcyon 88.3 6
schizophrenia 37 10
bipolar disorder 11.5 1
major depression 3.74 1
tumors 0 1

Relevant External Links for PPP1R9B

Genetic Association Database (GAD)
PPP1R9B
Human Genome Epidemiology (HuGE) Navigator
PPP1R9B
genes like me logo Genes that share disorders with PPP1R9B: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PPP1R9B Gene

Publications for PPP1R9B Gene

  1. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. (PMID: 9275233) Allen P.B. … Greengard P. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 23
  2. The human tumor suppressor ARF interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein. (PMID: 11278317) Vivo M. … La Mantia G. (J. Biol. Chem. 2001) 3 4 23
  3. The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines. (PMID: 12230305) Grossman S.D. … Greengard P. (Neuromolecular Med. 2002) 3 23
  4. Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. (PMID: 10194355) Hsieh-Wilson L.C. … Greengard P. (Biochemistry 1999) 3 23
  5. Identification of neurabin II as a novel doublecortin interacting protein. (PMID: 14550532) Tsukada M. … Eichele G. (Mech. Dev. 2003) 3 23

Products for PPP1R9B Gene

Sources for PPP1R9B Gene

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