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PPP1R9B Gene

protein-coding   GIFtS: 55
GCID: GC17M048211

Protein Phosphatase 1, Regulatory Subunit 9B

(Previous names: protein phosphatase 1, regulatory subunit 9B, spinophilin,...)
(Previous symbols: PPP1R6, PPP1R9)
  See PPP1R9B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 9B1 2     SPINO2
PPP1R61 2 3     Spn2
PPP1R91 2     neurabin-22
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9B1 2     neurabin-II2
Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin1 2     Neurabin-II3
Neurabin-21     Spinophilin3
spinophilin1     Protein Phosphatase 1 Regulatory Subunit 9B3

External Ids:    HGNC: 92981   Entrez Gene: 846872   Ensembl: ENSG000001088197   OMIM: 6033255   UniProtKB: Q96SB33   

Export aliases for PPP1R9B gene to outside databases

Previous GC identifers: GC17U990076 GC17M050692 GC17M048553 GC17M048687 GC17M048685 GC17M045567 GC17M043579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R9B Gene:
This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression
of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in
receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and
decreased expression has been observed in tumors. (provided by RefSeq, Feb 2014)

GeneCards Summary for PPP1R9B Gene:
PPP1R9B (protein phosphatase 1, regulatory subunit 9B) is a protein-coding gene. Diseases associated with PPP1R9B include limbic encephalitis, and schizophrenia. GO annotations related to this gene include protein phosphatase 1 binding and actin binding. An important paralog of this gene is SAMD14.

UniProtKB/Swiss-Prot: NEB2_HUMAN, Q96SB3
Function: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic
transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity.
Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma
membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are
rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and
NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including
dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic
neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin
cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling
specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by
forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration

Gene Wiki entry for PPP1R9B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R9B gene promoter:
         MZF-1   AREB6   CREB   Pax-5   NRF-2   HSF2   deltaCREB   FOXD3   ZIC2/Zic2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PPP1R9B promoter sequence
   Search Chromatin IP Primers for PPP1R9B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R9B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

PPP1R9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R9B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M048211:  view genomic region     (about GC identifiers)

Start:
48,211,101 bp from pter      End:
48,227,991 bp from pter
Size:
16,891 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NEB2_HUMAN, Q96SB3 (See protein sequence)
Recommended Name: Neurabin-2  
Size: 815 amino acids; 89192 Da
Subunit: Interacts with DCLK2 (By similarity). Possibly exists as a homodimer, homotrimer or a homotetramer.
Interacts with F-actin, PPP1CA, neurabin-1, TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4,
RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1 and TIAM1. Interacts (via C-terminus) with
SPATA13 (via C-terminal tail)
Secondary accessions: Q8TCR9

Explore the universe of human proteins at neXtProt for PPP1R9B: NX_Q96SB3

Explore proteomics data for PPP1R9B at MOPED

Post-translational modifications: 

  • Stimulation of D1 (but not D2) dopamine receptors induces Ser-94 phosphorylation. Dephosphorylation of Ser-94 is
    mediated mainly by PP1 and to a lesser extent by PP2A. Phosphorylation of spinophilin disrupts its association
    with F-actin, but does not affect its binding to PP1 (By similarity)1
  • Ubiquitination2 at Lys675, Lys687
  • Modification sites at PhosphoSitePlus

  • See PPP1R9B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115984.3  
    ENSEMBL proteins: 
     ENSP00000475417  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q96SB3

    ProtoNet protein and cluster: Q96SB3

    2 Blocks protein domains:
    IPB000515 Binding-protein-dependent transport systems inner membrane component
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: NEB2_HUMAN, Q96SB3
    Domain: The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a
    substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates (By similarity)
    Similarity: Contains 1 PDZ (DHR) domain


    Find genes that share domains with PPP1R9B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEB2_HUMAN, Q96SB3
    Function: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic
    transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity.
    Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma
    membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are
    rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and
    NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including
    dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic
    neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin
    cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling
    specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by
    forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004864protein phosphatase inhibitor activity NAS11278317
    GO:0005515protein binding IPI11278317
    GO:0008157protein phosphatase 1 binding NAS11278317
         
    Find genes that share ontologies with PPP1R9B           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp1r9b):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with PPP1R9B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppp1r9btm1Jfe for PPP1R9B

       genOway: Develop your customized and physiologically relevant rodent model for PPP1R9B

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    hsa-miR-3678-5p hsa-miR-632 hsa-miR-4267 hsa-miR-637 hsa-miR-3170 hsa-miR-200b hsa-miR-3612 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R9B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEB2_HUMAN, Q96SB3: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Cell projection, dendritic
    spine (By similarity). Cell junction, synapse. Cell junction, adherens junction (By similarity). Cytoplasm. Cell
    membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane.
    Note=Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and
    membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes
    with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines (By similarity).
    Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF)
    treatment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000164protein phosphatase type 1 complex TAS11278317
    GO:0005654nucleoplasm IMP11278317
    GO:0005737cytoplasm IDA11278317
    GO:0005886plasma membrane IDA19151759
    GO:0005912adherens junction IEA--

    Find genes that share ontologies with PPP1R9B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1R9B About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    4ERK Signaling
    ERK Signaling0.61
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60


    Find genes that share SuperPaths with PPP1R9B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1R9B (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Cell Signaling Technology (CST) Pathway for PPP1R9B
        Neuroscience

    1 Tocris Bioscience Pathway for PPP1R9B
        Insulin Pathway


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    Interactions:

        GeneGlobe Interaction Network for PPP1R9B

    Selected Interacting proteins for PPP1R9B (Q96SB31, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621361, 2, 3EBI-351275,EBI-357253 MINT-8290898 MINT-62199 MINT-8290911 MINT-8290954 I2D: score=5 
    DRD2P144162, 3MINT-4953534 I2D: score=6 
    ADRA1BP353682, 3MINT-4953469 I2D: score=2 
    CCKARP322382, 3MINT-4953493 I2D: score=2 
    CCKBRP322392, 3MINT-4953514 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001560regulation of cell growth by extracellular stimulus TAS11278317
    GO:0001932regulation of protein phosphorylation IEA--
    GO:0007015actin filament organization IEA--
    GO:0007050cell cycle arrest TAS11278317
    GO:0007096regulation of exit from mitosis NAS11278317

    Find genes that share ontologies with PPP1R9B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for PPP1R9B (NEB2)

    4 Novoseek inferred chemical compound relationships for PPP1R9B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    letrozole 63.8 6 15229239 (2), 16502389 (2), 16344155 (1), 20097718 (1)
    dopamine 37.5 4 16462601 (1), 10194355 (1), 16199832 (1), 17157277 (1)
    glutamate 33.3 7 17279777 (2), 15217898 (1), 15728359 (1), 12230305 (1) (see all 6)
    estradiol 28.7 2 12351732 (1), 15229239 (1)



    Find genes that share compounds with PPP1R9B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPP1R9B gene: 
    NM_032595.4  

    Unigene Cluster for PPP1R9B:

    Protein phosphatase 1, regulatory subunit 9B
    Hs.514323  [show with all ESTs]
    Unigene Representative Sequence: NM_032595
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000501501 ENST00000513579 ENST00000316878(uc002iqh.4)
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    Additional mRNA sequence: 

    AJ401189.1 AK054907.1 AL157449.1 AL713642.1 BC008564.1 BC011232.1 BC016162.1 

    5 DOTS entries:

    DT.312456  DT.95243515  DT.97868666  DT.100044479  DT.95072296 

    Selected AceView cDNA sequences (see all 135):

    BM460087 BF726761 BU620207 BM991997 AI251854 BC008564 AL157449 BC011232 
    BE646343 AI242565 AI766708 CO246370 BM695932 AW451413 AI056581 AI475690 
    AL713642 BQ006692 AI621262 AI475513 BM551747 BG393753 CA944794 BF111247 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R9B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                -                                                   
    SP2:                                -                                                   
    SP3:                                -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for PPP1R9B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R9B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCTGTCA
    PPP1R9B Expression
    About this image

    PPP1R9B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R9B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514323
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PPP1R9B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r9b1 , 5 protein phosphatase 1, regulatory subunit 9B1, 5 90.48(n)1
    96.08(a)1
      11 (59.01 cM)5
    2171241  NM_172261.31  NP_758465.21 
     949910355 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    29(a)
    many ↔ many
    7(17156217-17195097)
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R9B6
    protein phosphatase 1, regulatory subunit 9B
    72(a)
    1 ↔ 1
    6(77371655-77457611)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppp1r9b1 protein phosphatase 1, regulatory subunit 9B 65.58(n)
    70.2(a)
      100490992  XM_002935559.2  XP_002935605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.140452 Transcribed sequence with weak similarity to protein more 81.4(n)    BI840817.1 


    ENSEMBL Gene Tree for PPP1R9B (if available)
    TreeFam Gene Tree for PPP1R9B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R9B gene
    SAMD142  PPP1R9A2  MLLT42  
    3 SIMAP similar genes for PPP1R9B using alignment to 4 protein entries:     NEB2_HUMAN (see all proteins):
    PPP1R9A    DLG4    TJP2

    Find genes that share paralogs with PPP1R9B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPP1R9B (see all 411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146971391,2
    Cuntested143586594(+) ACCAGA/G/TAGATC 2 L syn12WA EU 685
    rs2013135681,2
    Cuntested143588872(+) GTCACA/GGTCTT 2 T syn10--------
    rs1996011131,2
    Cuntested143588953(+) CCCTCA/GGAGTC 2 S syn10--------
    rs2003001071,2
    Cuntested143594422(+) CTCGGA/GGCTGG 2 A syn10--------
    rs1998650661,2
    Cuntested143594617(+) TCATCT/CACCTC 2 /V syn11Minor allele frequency- C:0.00EU 563
    rs1143988711,2
    C--43578562(+) ACTGCC/TAGGCA 1 -- int10--------
    rs1847101861,2
    --43578566(+) CCAGGC/GAGTCA 1 -- int10--------
    rs1131837411,2
    F--43578595(+) CCTTTG/TATCCT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1816637301,2
    --43578612(+) GCCTCA/GCACCG 1 -- int10--------
    rs1394473371,2
    --43578616(+) CACACC/TGGGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PPP1R9B (48211101 - 48227991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PPP1R9B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3226n71CNV Loss21882294
    nsv908588CNV Loss21882294
    dgv3225n71CNV Loss21882294
    nsv828038CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PPP1R9B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R9B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603325    OMIM disorders: --

    2 diseases for PPP1R9B:    
    About MalaCards
    limbic encephalitis    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for PPP1R9B:
    Schizophrenia     Lissencephaly

    Find genes that share disorders with PPP1R9B           About GenesLikeMe

    5 Novoseek inferred disease relationships for PPP1R9B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 88.3 6 16199832 (3), 12622665 (2), 16786528 (1)
    schizophrenia 37 10 15465982 (3), 16199832 (2), 15184234 (2), 16786528 (1) (see all 6)
    bipolar disorder 11.5 1 15465982 (1)
    major depression 3.74 1 15465982 (1)
    tumors 0 2 11278317 (1)

    Genetic Association Database (GAD): PPP1R9B
    Human Genome Epidemiology (HuGE) Navigator: PPP1R9B (1 document)

    Export disorders for PPP1R9B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R9B gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with PPP1R9B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human tumor suppressor ARF interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein. (PubMed id 11278317)1, 2, 9 Vivo M.... La Mantia G. (J. Biol. Chem. 2001)
    2. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. (PubMed id 9275233)1, 3, 9 Allen P.B....Greengard P. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. (PubMed id 19151759)1, 2 Sagara M.... Akiyama T. (Oncogene 2009)
    5. Phosphorylation of spinophilin modulates its interaction with actin filaments. (PubMed id 12417592)1, 9 Hsieh-Wilson L.C....Greengard P. (J. Biol. Chem. 2003)
    6. Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). (PubMed id 20360004)1, 9 Rajagopal S....Buchsbaum R.J. (J. Biol. Chem. 2010)
    7. Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). (PubMed id 15728359)1, 9 Futter M....Nairn A.C. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    8. Identification of neurabin II as a novel doublecortin interacting protein. (PubMed id 14550532)1, 9 Tsukada M....Eichele G. (Mech. Dev. 2003)
    9. The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines. (PubMed id 12230305)1, 9 Grossman S.D....Greengard P. (Neuromolecular Med. 2002)
    10. Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. (PubMed id 10194355)1, 9 Hsieh-Wilson L.C....Greengard P. (Biochemistry 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84687 HGNC: 9298 AceView: PPP1R9B Ensembl:ENSG00000108819 euGenes: HUgn84687
    ECgene: PPP1R9B H-InvDB: PPP1R9B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R9B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPP1R9B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R9B gene:
    Search GeneIP for patents involving PPP1R9B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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