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Aliases for PPP1R7 Gene

Aliases for PPP1R7 Gene

  • Protein Phosphatase 1, Regulatory Subunit 7 2 3
  • SDS22 3 4 6
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 7 2 3
  • Protein Phosphatase 1 Regulatory Subunit 22 3 4
  • Protein Phosphatase 1 Regulatory Subunit 7 3

External Ids for PPP1R7 Gene

Summaries for PPP1R7 Gene

Entrez Gene Summary for PPP1R7 Gene

  • This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PPP1R7 Gene

PPP1R7 (Protein Phosphatase 1, Regulatory Subunit 7) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include enzyme regulator activity and protein phosphatase type 1 regulator activity. An important paralog of this gene is CNTRL.

UniProtKB/Swiss-Prot for PPP1R7 Gene

  • Regulatory subunit of protein phosphatase 1.

Gene Wiki entry for PPP1R7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R7 Gene

Genomics for PPP1R7 Gene

Genomic Location for PPP1R7 Gene

Start:
241,149,573 bp from pter
End:
241,183,652 bp from pter
Size:
34,080 bases
Orientation:
Plus strand

Genomic View for PPP1R7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPP1R7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R7 Gene

Regulatory Elements for PPP1R7 Gene

Proteins for PPP1R7 Gene

  • Protein details for PPP1R7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15435-PP1R7_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 7
    Protein Accession:
    Q15435
    Secondary Accessions:
    • B4DFD4
    • B5MCY6
    • Q9UQE5
    • Q9UQE6
    • Q9Y6K4

    Protein attributes for PPP1R7 Gene

    Size:
    360 amino acids
    Molecular mass:
    41564 Da
    Quaternary structure:
    • Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G isoform 1.

    Alternative splice isoforms for PPP1R7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R7 Gene

Proteomics data for PPP1R7 Gene at MOPED

Post-translational modifications for PPP1R7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys90, Lys111, Lys162, Lys168, Lys175, Lys178, Lys222, and Lys244

No data available for DME Specific Peptides for PPP1R7 Gene

Domains for PPP1R7 Gene

Gene Families for PPP1R7 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

UniProtKB/Swiss-Prot:

PP1R7_HUMAN
Domain:
  • Contains 1 LRRCT domain.:
    • Q15435
Family:
  • Belongs to the SDS22 family.:
    • Q15435
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.:
    • Q15435
genes like me logo Genes that share domains with PPP1R7: view

Function for PPP1R7 Gene

Molecular function for PPP1R7 Gene

GENATLAS Biochemistry: protein phosphatase 1,41.6kDa,regulatory subunit 7,yeast sds 22 homolog
UniProtKB/Swiss-Prot Function: Regulatory subunit of protein phosphatase 1.

Gene Ontology (GO) - Molecular Function for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008599 protein phosphatase type 1 regulator activity TAS 7498485
GO:0030234 enzyme regulator activity NAS 10231361
genes like me logo Genes that share ontologies with PPP1R7: view

Phenotypes for PPP1R7 Gene

genes like me logo Genes that share phenotypes with PPP1R7: view

miRNA for PPP1R7 Gene

miRTarBase miRNAs that target PPP1R7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPP1R7 Gene

Localization for PPP1R7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R7 Gene COMPARTMENTS Subcellular localization image for PPP1R7 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005694 chromosome IDA 22801782
GO:0005737 cytoplasm TAS 7498485
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PPP1R7: view

Pathways for PPP1R7 Gene

genes like me logo Genes that share pathways with PPP1R7: view

Pathways by source for PPP1R7 Gene

Gene Ontology (GO) - Biological Process for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA --
GO:0008150 biological_process ND --
GO:0035307 positive regulation of protein dephosphorylation IMP 22801782
GO:0050790 regulation of catalytic activity TAS 7498485
genes like me logo Genes that share ontologies with PPP1R7: view

Transcripts for PPP1R7 Gene

Unigene Clusters for PPP1R7 Gene

Protein phosphatase 1, regulatory subunit 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - -
SP10: - - -
SP11: - -
SP12: - - - -
SP13: - -

Relevant External Links for PPP1R7 Gene

GeneLoc Exon Structure for
PPP1R7
ECgene alternative splicing isoforms for
PPP1R7

Expression for PPP1R7 Gene

mRNA expression in normal human tissues for PPP1R7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R7 Gene

SOURCE GeneReport for Unigene cluster for PPP1R7 Gene Hs.36587

mRNA Expression by UniProt/SwissProt for PPP1R7 Gene

Q15435-PP1R7_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with PPP1R7: view

Orthologs for PPP1R7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1R7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R7 36
  • 99.54 (n)
  • 99.72 (a)
PPP1R7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R7 36
  • 88.52 (n)
  • 93.06 (a)
PPP1R7 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 56 (a)
OneToMany
PPP1R7 36
  • 91.3 (n)
  • 94.72 (a)
mouse
(Mus musculus)
Mammalia Ppp1r7 36
  • 88.06 (n)
  • 94.17 (a)
Ppp1r7 16
Ppp1r7 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R7 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r7 36
  • 88.33 (n)
  • 95.28 (a)
chicken
(Gallus gallus)
Aves PPP1R7 36
  • 78.44 (n)
  • 85.03 (a)
PPP1R7 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R7 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19668 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r7 36
  • 67.92 (n)
  • 73.7 (a)
Str.6727 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.185 36
zebrafish
(Danio rerio)
Actinopterygii Dr.4202 36
ppp1r7 36
  • 70.51 (n)
  • 78.98 (a)
ppp1r7 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009839 36
  • 58.48 (n)
  • 58.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta sds22 36
  • 55.98 (n)
  • 54.14 (a)
sds22 37
  • 50 (a)
OneToOne
sds22 38
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea C06A8.6 37
  • 40 (a)
OneToMany
K10D2.8 37
  • 36 (a)
OneToMany
sds-22 37
  • 45 (a)
OneToMany
T09A5.9 36
  • 52.68 (n)
  • 48.25 (a)
T09A5.9 38
  • 46 (a)
C06A8.6 38
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER104W 36
  • 54.21 (n)
  • 51.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDS22 36
  • 51.44 (n)
  • 50.17 (a)
SDS22 37
  • 45 (a)
OneToMany
SDS22 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02816g 36
  • 53.36 (n)
  • 53.36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19680 36
  • 49.88 (n)
  • 40.91 (a)
rice
(Oryza sativa)
Liliopsida Os02g0230100 36
  • 48.98 (n)
  • 41.6 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08385 36
  • 55.6 (n)
  • 50.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sds22 36
  • 51.43 (n)
  • 50.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5923 37
  • 61 (a)
OneToOne
Species with no ortholog for PPP1R7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R7 Gene

ENSEMBL:
Gene Tree for PPP1R7 (if available)
TreeFam:
Gene Tree for PPP1R7 (if available)

Paralogs for PPP1R7 Gene

Paralogs for PPP1R7 Gene

Selected SIMAP similar genes for PPP1R7 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PPP1R7: view

Variants for PPP1R7 Gene

Sequence variations from dbSNP and Humsavar for PPP1R7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3868 -- 241,182,976(-) GTGTG(A/G)CGTCG utr-variant-3-prime
rs11741 -- 241,183,405(+) GGGCA(A/G)GGCTG utr-variant-3-prime
rs12719 -- 241,182,971(+) GCGCG(C/T)GACGT utr-variant-3-prime
rs719564 -- 241,161,953(+) TCAGA(A/G)TGCCC intron-variant
rs758075 -- 241,177,905(+) GGGGC(C/T)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R7 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv3241 CNV Insertion 18451855
esv26576 CNV Loss 19812545
dgv4492n71 CNV Loss 21882294
nsv508900 CNV Insertion 20534489
esv2423265 CNV Insertion 19546169
nsv512791 CNV Insertion 21212237

Relevant External Links for PPP1R7 Gene

HapMap Linkage Disequilibrium report
PPP1R7

Disorders for PPP1R7 Gene

Relevant External Links for PPP1R7

Genetic Association Database (GAD)
PPP1R7
genes like me logo Genes that share disorders with PPP1R7: view

No data available for UniProtKB/Swiss-Prot for PPP1R7 Gene

Publications for PPP1R7 Gene

  1. Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1. (PMID: 10231361) Ceulemans H. … Bollen M. (Eur. J. Biochem. 1999) 2 3 4 23
  2. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. (PMID: 7498485) Renouf S. … Bollen M. (FEBS Lett. 1995) 2 3 4
  3. Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map. (PMID: 7670491) Berry R. … Sikela J.M. (Nat. Genet. 1995) 2 3
  4. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. (PMID: 17630778) Lesage B. … Bollen M. (Biochemistry 2007) 3 23
  5. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PMID: 12226088) Ceulemans H. … Bollen M. (J. Biol. Chem. 2002) 3 4

Products for PPP1R7 Gene

Sources for PPP1R7 Gene

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