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Aliases for PPP1R7 Gene

Aliases for PPP1R7 Gene

  • Protein Phosphatase 1 Regulatory Subunit 7 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 7 2 3
  • Protein Phosphatase 1 Regulatory Subunit 22 3 4
  • SDS22 3 4
  • Testis Secretory Sperm-Binding Protein Li 210a 3
  • Protein Phosphatase 1, Regulatory Subunit 7 2

External Ids for PPP1R7 Gene

Previous GeneCards Identifiers for PPP1R7 Gene

  • GC02M239317
  • GC02M240174
  • GC02P242108
  • GC02P242409
  • GC02P242410
  • GC02P241809
  • GC02P241737
  • GC02P233846
  • GC02P242088

Summaries for PPP1R7 Gene

Entrez Gene Summary for PPP1R7 Gene

  • This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PPP1R7 Gene

PPP1R7 (Protein Phosphatase 1 Regulatory Subunit 7) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include enzyme regulator activity. An important paralog of this gene is LRRC9.

UniProtKB/Swiss-Prot for PPP1R7 Gene

  • Regulatory subunit of protein phosphatase 1.

Gene Wiki entry for PPP1R7 Gene

Additional gene information for PPP1R7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R7 Gene

Genomics for PPP1R7 Gene

Regulatory Elements for PPP1R7 Gene

Enhancers for PPP1R7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H241108 1.3 Ensembl ENCODE dbSUPER 11.7 -38.9 -38904 5.3 HDGF PKNOX1 TBL1XR1 EBF1 ZBTB40 RELA POLR2A EED RUNX3 IKZF2 PASK MTERF4 PPP1R7 ANO7 ENSG00000229996 LOC100422094 PIR57971 GC02M241112
GH02H241091 1.2 ENCODE dbSUPER 11.2 -56.5 -56512 2.7 FOXA2 ATF1 MLX ARID4B DMAP1 SLC30A9 SP5 MXD4 NFYC PPARG PASK MTERF4 ANO7 PPP1R7 ENSG00000229996 D2HGDH GC02P241081
GH02H241094 1.1 ENCODE dbSUPER 11.8 -53.1 -53148 3.2 HDGF PKNOX1 TBL1XR1 BACH1 BMI1 EBF1 BATF RELA POLR2A EED PASK MTERF4 PPP1R7 ENSG00000229996 GC02P241081
GH02H241616 1.2 ENCODE dbSUPER 9.9 +469.4 469434 4.1 HDGF PKNOX1 GLI4 YY1 ETS1 ZNF143 FOS SP3 YY2 REST ENSG00000223374 ING5 SNED1 ENSG00000235351 MTERF4 FARP2 BOK D2HGDH DTYMK SEPT2
GH02H241372 1.1 ENCODE dbSUPER 10.7 +224.5 224484 3.9 PKNOX1 TBL1XR1 KLF17 BMI1 BATF SCRT2 FOS ATF7 ETV6 RCOR1 HDLBP ANO7 SEPT2 STK25 PASK PPP1R7 D2HGDH ENSG00000234793 LOC105373973 GC02P241444
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R7 on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133237 427 2401 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS SP3

Genomic Locations for PPP1R7 Gene

Genomic Locations for PPP1R7 Gene
34,080 bases
Plus strand

Genomic View for PPP1R7 Gene

Genes around PPP1R7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R7 Gene

Proteins for PPP1R7 Gene

  • Protein details for PPP1R7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 7
    Protein Accession:
    Secondary Accessions:
    • B4DFD4
    • B5MCY6
    • Q9UQE5
    • Q9UQE6
    • Q9Y6K4

    Protein attributes for PPP1R7 Gene

    360 amino acids
    Molecular mass:
    41564 Da
    Quaternary structure:
    • Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G isoform 1.

    Alternative splice isoforms for PPP1R7 Gene


neXtProt entry for PPP1R7 Gene

Post-translational modifications for PPP1R7 Gene

  • Ubiquitination at Lys90, posLast=111111, Lys162, Lys168, posLast=175175, Lys178, Lys222, and Lys244
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP1R7 Gene

Domains & Families for PPP1R7 Gene

Gene Families for PPP1R7 Gene

Suggested Antigen Peptide Sequences for PPP1R7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SDS22 family.
  • Belongs to the SDS22 family.
genes like me logo Genes that share domains with PPP1R7: view

Function for PPP1R7 Gene

Molecular function for PPP1R7 Gene

GENATLAS Biochemistry:
protein phosphatase 1,41.6kDa,regulatory subunit 7,yeast sds 22 homolog
UniProtKB/Swiss-Prot Function:
Regulatory subunit of protein phosphatase 1.

Gene Ontology (GO) - Molecular Function for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
GO:0019888 protein phosphatase regulator activity TAS 7498485
GO:0030234 enzyme regulator activity NAS 10231361
genes like me logo Genes that share ontologies with PPP1R7: view
genes like me logo Genes that share phenotypes with PPP1R7: view

Animal Model Products

CRISPR Products

miRNA for PPP1R7 Gene

miRTarBase miRNAs that target PPP1R7

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R7 Gene

Localization for PPP1R7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 21630459
GO:0005694 chromosome IDA 22801782
GO:0005737 cytoplasm TAS 7498485
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PPP1R7: view

Pathways & Interactions for PPP1R7 Gene

genes like me logo Genes that share pathways with PPP1R7: view

Pathways by source for PPP1R7 Gene

Gene Ontology (GO) - Biological Process for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA --
GO:0008150 biological_process ND --
GO:0035307 positive regulation of protein dephosphorylation IMP 22801782
GO:0050790 regulation of catalytic activity IEA --
GO:0061588 calcium activated phospholipid scrambling IEA --
genes like me logo Genes that share ontologies with PPP1R7: view

No data available for SIGNOR curated interactions for PPP1R7 Gene

Drugs & Compounds for PPP1R7 Gene

No Compound Related Data Available

Transcripts for PPP1R7 Gene

Unigene Clusters for PPP1R7 Gene

Protein phosphatase 1, regulatory subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - -
SP10: - - -
SP11: - -
SP12: - - - -
SP13: - -

Relevant External Links for PPP1R7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R7 Gene

This gene is overexpressed in Skin (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R7 Gene

Protein tissue co-expression partners for PPP1R7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R7 Gene:


SOURCE GeneReport for Unigene cluster for PPP1R7 Gene:


mRNA Expression by UniProt/SwissProt for PPP1R7 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PPP1R7 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Lung(3)
genes like me logo Genes that share expression patterns with PPP1R7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R7 Gene

Orthologs for PPP1R7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1R7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R7 33 34
  • 99.54 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R7 34
  • 92 (a)
(Canis familiaris)
Mammalia PPP1R7 33
  • 91.3 (n)
-- 34
  • 84 (a)
-- 34
  • 56 (a)
(Bos Taurus)
Mammalia PPP1R7 33 34
  • 88.52 (n)
(Rattus norvegicus)
Mammalia Ppp1r7 33
  • 88.33 (n)
(Mus musculus)
Mammalia Ppp1r7 33 16 34
  • 88.06 (n)
(Gallus gallus)
Aves PPP1R7 33 34
  • 78.44 (n)
(Anolis carolinensis)
Reptilia PPP1R7 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r7 33
  • 67.92 (n)
Str.6727 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19668 33
(Danio rerio)
Actinopterygii ppp1r7 33 34
  • 70.51 (n)
Dr.4202 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.185 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009839 33
  • 58.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta sds22 35 33 34
  • 55.98 (n)
(Caenorhabditis elegans)
Secernentea T09A5.9 35 33
  • 52.68 (n)
sds-22 34
  • 45 (a)
C06A8.6 35 34
  • 44 (a)
K10D2.8 34
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER104W 33
  • 54.21 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02816g 33
  • 53.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDS22 33 34 36
  • 51.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19680 33
  • 49.88 (n)
(Oryza sativa)
Liliopsida Os02g0230100 33
  • 48.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5923 34
  • 61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08385 33
  • 55.6 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sds22 33
  • 51.43 (n)
Species where no ortholog for PPP1R7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R7 Gene

Gene Tree for PPP1R7 (if available)
Gene Tree for PPP1R7 (if available)

Paralogs for PPP1R7 Gene

Paralogs for PPP1R7 Gene

(2) SIMAP similar genes for PPP1R7 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PPP1R7: view

Variants for PPP1R7 Gene

Sequence variations from dbSNP and Humsavar for PPP1R7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000007756 -- 241,164,981(+) AGGAG(A/G)ACATT intron-variant
rs1000010692 -- 241,149,177(+) GCTGG(A/G)GGCGC intron-variant, upstream-variant-2KB
rs1000041848 -- 241,148,985(+) CCCCG(A/C)GGCGC intron-variant, upstream-variant-2KB
rs1000074803 -- 241,177,384(+) TGCAC(G/T)CTAGC intron-variant
rs1000195562 -- 241,153,976(+) GGAGA(G/T)CAAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPP1R7 Gene

Variant ID Type Subtype PubMed ID
nsv512791 CNV insertion 21212237
nsv508900 CNV insertion 20534489
nsv3241 CNV insertion 18451855
esv3575345 CNV gain 25503493
esv3397077 CNV duplication 20981092
esv26576 CNV loss 19812545
esv2423265 CNV insertion 19546169

Variation tolerance for PPP1R7 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R7 Gene

Disorders for PPP1R7 Gene

Relevant External Links for PPP1R7

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R7 Gene

Publications for PPP1R7 Gene

  1. Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1. (PMID: 10231361) Ceulemans H … Bollen M (European journal of biochemistry 1999) 2 3 4 22 60
  2. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. (PMID: 7498485) Renouf S … Bollen M (FEBS letters 1995) 2 3 4 60
  3. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. (PMID: 17630778) Lesage B … Bollen M (Biochemistry 2007) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PMID: 12226088) Ceulemans H … Bollen M (The Journal of biological chemistry 2002) 3 4 60

Products for PPP1R7 Gene

Sources for PPP1R7 Gene

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