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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPP1R7 Gene

protein-coding   GIFtS: 60
GCID: GC02P242088

Protein Phosphatase 1, Regulatory Subunit 7

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory Subunit 71 2
SDS222 3 5
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 71 2
Protein Phosphatase 1 Regulatory Subunit 222 3
Protein Phosphatase 1 Regulatory Subunit 72

External Ids:    HGNC: 92951   Entrez Gene: 55102   Ensembl: ENSG000001156857   OMIM: 6028775   UniProtKB: Q154353   

Export aliases for PPP1R7 gene to outside databases

Previous GC identifers: GC02M239317 GC02M240174 GC02P242108 GC02P242409 GC02P242410 GC02P241809 GC02P241737 GC02P233846


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R7 Gene:
This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein
phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein
phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Sep 2013)

GeneCards Summary for PPP1R7 Gene: 
PPP1R7 (protein phosphatase 1, regulatory subunit 7) is a protein-coding gene. Diseases associated with PPP1R7 include cervix uteri carcinoma in situ, and cervical cancer, and among its related super-pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include enzyme regulator activity and protein phosphatase type 1 regulator activity. An important paralog of this gene is LRRC48.

UniProtKB/Swiss-Prot: PP1R7_HUMAN, Q15435
Function: Regulatory subunit of protein phosphatase 1 (By similarity)

Gene Wiki entry for PPP1R7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005416.13  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPP1R7 gene promoter:
         Egr-2   AREB6   NF-1   NF-1/L   Pax-5   AML1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPP1R7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

PPP1R7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P242088:  view genomic region     (about GC identifiers)

Start:
242,088,991 bp from pter      End:
242,123,067 bp from pter
Size:
34,077 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PP1R7_HUMAN, Q15435 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 7  
Size: 360 amino acids; 41564 Da
Subunit: Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G isoform 1
Subcellular location: Nucleus (By similarity)
Secondary accessions: B4DFD4 Q9UQE5 Q9UQE6 Q9Y6K4
Alternative splicing: 4 isoforms:  Q15435-1   Q15435-2   Q15435-3   Q15435-4   

Explore the universe of human proteins at neXtProt for PPP1R7: NX_Q15435

Explore proteomics data for PPP1R7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15435

  • PPP1R7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPP1R7 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001269338.1  NP_001269339.1  NP_001269340.1  NP_001269341.1  NP_001269342.1  NP_001269343.1  NP_002703.1  

    ENSEMBL proteins: 
     ENSP00000396376   ENSP00000385012   ENSP00000412092   ENSP00000385657   ENSP00000272983  
     ENSP00000234038   ENSP00000385498   ENSP00000409719   ENSP00000385022   ENSP00000385466  
     ENSP00000397985   ENSP00000392373   ENSP00000413360  

    Human Recombinant Protein Products for PPP1R7: 
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    Cloud-Clone Corp. Proteins for PPP1R7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS7498485

    PPP1R7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003603 U2A'_phosphoprotein32A_C

    Graphical View of Domain Structure for InterPro Entry Q15435

    ProtoNet protein and cluster: Q15435

    2 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB003603 Leucine-rich-associated


    UniProtKB/Swiss-Prot: PP1R7_HUMAN, Q15435
    Similarity: Belongs to the SDS22 family
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    PPP1R7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PP1R7_HUMAN, Q15435
    Function: Regulatory subunit of protein phosphatase 1 (By similarity)

         Genatlas biochemistry entry for PPP1R7:
    protein phosphatase 1,41.6kDa,regulatory subunit 7,yeast sds 22 homolog

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008599protein phosphatase type 1 regulator activity TAS7498485
    GO:0030234enzyme regulator activity NAS10231361
         
    PPP1R7 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PPP1R7:
     Apoptosis resistance  Increased S DNA content  Increased cell death in HCT116  S arrest 

    Animal Models:
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    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R7:
    hsa-miR-3164 hsa-miR-132* hsa-miR-548d-3p hsa-miR-137 hsa-miR-134 hsa-miR-943 hsa-miR-3118 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R7 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPP1R7 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Erythropoietin Pathway
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3PEDF Induced Signaling
    IL-6 Pathway0.61
    4Rho Family GTPases
    ERK Signaling0.61
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R7 (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R7
        Insulin Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPP1R7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/49 Interacting proteins for PPP1R7 (Q154352, 3 ENSP000002340384) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261703 I2D: score=2 
    TAB1Q157502, 3MINT-8260284 I2D: score=2 
    PPP1CCP368733, ENSP000003350844I2D: score=5 STRING: ENSP00000335084
    RPTORQ8N1223, ENSP000003072724I2D: score=4 STRING: ENSP00000307272
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0050790regulation of catalytic activity NAS10231361

    PPP1R7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PPP1R7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPP1R7 (PP1R7)

    Search CenterWatch for drugs/clinical trials and news about PPP1R7 / PP1R7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPP1R7 gene (7 alternative transcripts): 
    NM_001282409.1  NM_001282410.1  NM_001282411.1  NM_001282412.1  NM_001282413.1  NM_001282414.1  NM_002712.2  

    Unigene Cluster for PPP1R7:

    Protein phosphatase 1, regulatory subunit 7
    Hs.36587  [show with all ESTs]
    Unigene Representative Sequence: BC051689
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000438799(uc010fzm.1) ENST00000402734 ENST00000423280 ENST00000407025(uc002wat.1 uc002wau.1)
    ENST00000272983 ENST00000234038 ENST00000404405 ENST00000473017 ENST00000439916
    ENST00000406106(uc002was.3) ENST00000498170 ENST00000493374 ENST00000401987
    ENST00000427172 ENST00000450367 ENST00000467159 ENST00000485630 ENST00000491715

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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R7:
    hsa-miR-3164 hsa-miR-132* hsa-miR-548d-3p hsa-miR-137 hsa-miR-134 hsa-miR-943 hsa-miR-3118 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R7 3' UTR sequence
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    Additional mRNA sequence: 

    AK294043.1 AK308015.1 BC000910.2 BC012397.1 BC013001.2 BC051689.1 BT007296.1 BT020134.1 
    Z50749.1 

    23 DOTS entries:

    DT.92448503  DT.418679  DT.92448510  DT.120990911  DT.120991030  DT.87017247  DT.100846196  DT.100846195 
    DT.120990943  DT.92448508  DT.97860033  DT.101959515  DT.101971122  DT.120990895  DT.120990969  DT.120990975 
    DT.120990992  DT.121626312  DT.92448509  DT.95167060  DT.95167061  DT.95167062  DT.97798528 

    24/469 AceView cDNA sequences (see all 469):

    CR594437 CD366654 BU622868 CR609492 BM687176 BX341115 CB154610 BP341392 
    BG258114 AA368239 BG105725 BG260343 BG576838 BQ683241 BF037992 AA716472 
    CB157725 BQ676807 BE727720 AI333089 BU634055 BM831645 BI913944 AI168808 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R7 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                      -     -                       -     -     -     -                                   -                     
    SP2:                                      -     -                       -     -     -     -                                                         
    SP3:                                      -     -                 -     -     -     -     -                                                         
    SP4:              -     -     -     -     -     -                       -     -     -     -                                                         
    SP5:                          -     -     -     -                       -     -     -     -                                                         


    ECgene alternative splicing isoforms for PPP1R7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPP1R7 expression in normal human tissues (normalized intensities)      PPP1R7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCCCTCT
    PPP1R7 Expression
    About this image


    PPP1R7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Testis (Reproductive System)

    See PPP1R7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPP1R7

    SOURCE GeneReport for Unigene cluster: Hs.36587

    UniProtKB/Swiss-Prot: PP1R7_HUMAN, Q15435
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPP1R7 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r71 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 88.06(n)1
    94.17(a)1
      1 (47.24 cM)5
    663851  NM_023200.21  NP_075689.11 
     933428545 
    chicken
    (Gallus gallus)
    Aves PPP1R71 protein phosphatase 1, regulatory (inhibitor) subunit more 79.08(n)
    86.53(a)
      424844  XM_422655.3  XP_422655.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R76
    Uncharacterized protein
    78(a)
    1 ↔ 1
    3(30132729-30157307)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.196682 Xenopus laevis transcribed sequence with moderate similarity more 73.78(n)    CF548479.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.42022 Transcribed sequence with moderate similarity to protein more 73.91(n)    AL726332.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sds221 , 3 protein phosphatase type 1, regulator3
    CG5851-PA1
    54(a)3
    55.98(n)1
    54.14(a)1
      90A53
    420911  NM_142362.31  NP_650619.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T09A5.93
    C06A8.61
    SDS22 protein3
    Protein C06A8.61
    46(a)
    (best of 2)3
    49.84(n)1
    44.3(a)1
      II(7858343-7859601)3
    1742531  NM_063233.21  NP_495634.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SDS22(YKL193C)4
    SDS221
    Conserved nuclear regulatory subunit of Glc7p type more4
    Sds22p1
    50.91(n)1
    49.2(a)1
      11(79882-78866)4
    8536411, 4  NP_012728.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G196801 leucine-rich repeat-containing protein 49.88(n)
    40.91(a)
      832088  NM_121973.4  NP_197469.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02301001 hypothetical protein 47.6(n)
    39.65(a)
      4328803  NM_001052899.1  NP_001046364.1 


    ENSEMBL Gene Tree for PPP1R7 (if available)
    TreeFam Gene Tree for PPP1R7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPP1R7 gene
    LRRC482  DNAAF12  LRRC92  CNTRL2  LRRC492  
    1 SIMAP similar gene for PPP1R7 using alignment to 9 protein entries:     PP1R7_HUMAN (see all proteins):
    LRRC49

    PPP1R7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/809 SNPs in PPP1R7 are shown (see all 809)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864863441,2
    --241448847(+) AAGAAC/GTCTTT 1 -- int10--------
    rs1909206331,2
    --241448873(+) CCAGAA/GAGGAG 1 -- int10--------
    rs1458542981,2
    C--241448990(+) TTAAGA/GATTCA 1 -- int10--------
    rs1830688131,2
    --241449049(+) AGGGAC/TCATGT 1 -- int10--------
    rs1869332271,2
    --241449125(+) ATTAAA/GGTAGC 1 -- int10--------
    rs1913735601,2
    --241449194(+) GATGCA/GGAAGG 1 -- int10--------
    rs1831875721,2
    C--241449273(+) AAAAAA/GTTAAG 1 -- int10--------
    rs1451003361,2
    C--241449316(+) CGCCG-/GCGGCGCGC
    GCCCCCGACCCC
    GCGGC
    1 -- int10--------
    rs13736901,2
    C,F,A--241449583(+) ACGGAA/GAGGAC 1 -- int112Minor allele frequency- G:0.40EA MN NA WA CSA 734
    rs351968831,2
    C--241449643(-) AGCCCG/TACCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PPP1R7 (242088991 - 242123067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PPP1R7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3241CNV Insertion18451855
    esv2423265CNV Insertion19546169
    nsv508900CNV Insertion20534489
    nsv512791CNV Insertion21212237
    dgv4492n71CNV Loss21882294
    nsv876116CNV Loss21882294
    esv26576CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602877    OMIM disorders: --

    4 diseases for PPP1R7:    About MalaCards
    cervix uteri carcinoma in situ    cervical cancer    cervicitis    breast cancer


    PPP1R7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPP1R7

    Export disorders for PPP1R7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPP1R7 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PPP1R7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1. (PubMed id 10231361)1, 2, 3, 9 Ceulemans H.... Bollen M. (1999)
    2. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. (PubMed id 7498485)1, 2, 3 Renouf S....Bollen M. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PubMed id 12226088)1, 2 Ceulemans H....Bollen M. (2002)
    5. Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map. (PubMed id 7670491)1, 3 Berry R....Sikela J.M. (1995)
    6. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. (PubMed id 17630778)1, 9 Lesage B....Bollen M. (2007)
    7. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. (PubMed id 22801782)1 Wurzenberger C....Gerlich D.W. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5510 HGNC: 9295 AceView: PPP1R7 Ensembl:ENSG00000115685 euGenes: HUgn5510
    ECgene: PPP1R7 H-InvDB: PPP1R7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPP1R7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPP1R7 gene:
    Search GeneIP for patents involving PPP1R7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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