Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R3F Gene

Aliases for PPP1R3F Gene

  • Protein Phosphatase 1 Regulatory Subunit 3F 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3F 2 3
  • R3F 3 4
  • Protein Phosphatase 1, Regulatory Subunit 3F 2
  • LL0XNC01-7P3.1 3
  • HB2E 3

External Ids for PPP1R3F Gene

Previous GeneCards Identifiers for PPP1R3F Gene

  • GC0XP047907
  • GC0XP047365
  • GC0XP048152
  • GC0XP048882
  • GC0XP049013
  • GC0XP049126
  • GC0XP046782

Summaries for PPP1R3F Gene

Entrez Gene Summary for PPP1R3F Gene

  • This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PPP1R3F Gene

PPP1R3F (Protein Phosphatase 1 Regulatory Subunit 3F) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein phosphatase binding and glycogen binding.

UniProtKB/Swiss-Prot for PPP1R3F Gene

  • Glycogen-targeting subunit for protein phosphatase 1 (PP1).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3F Gene

Genomics for PPP1R3F Gene

Regulatory Elements for PPP1R3F Gene

Enhancers for PPP1R3F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF049291 1.2 Ensembl ENCODE 13 +22.4 22372 0.8 ELF3 HDGF HDAC1 PKNOX1 TBL1XR1 ARNT NFRKB RAD21 ZNF766 GATA2 GAGE13 PPP1R3F FOXP3 PIR47304 ENSG00000270012
GH0XF049840 0.9 ENCODE 4.3 +572.4 572429 3.8 ELF3 ARID4B BMI1 RAD21 ZBTB40 RARA ELK1 CREM THAP11 ZNF654 CLCN5 PPP1R3F PAGE4 USP27X-AS1
GH0XF048933 1.8 FANTOM5 Ensembl ENCODE 2.1 -331.3 -331329 9.7 HDGF PKNOX1 ARNT WRNIP1 ZFP64 SIN3A ARID4B YBX1 DMAP1 SLC30A9 WAS OTUD5 PQBP1 SLC35A2 ZNF182 TIMM17B USP27X-AS1 ZNF630 PIM2 TBC1D25
GH0XF049282 1.1 FANTOM5 ENCODE 2.8 +13.1 13051 0.6 BCOR CTCF CDC5L RAD21 RFX5 ZFHX2 GATA3 ZBTB48 PRDM10 ZNF600 PPP1R3F FOXP3 ENSG00000270012 PIR47304
GH0XF048916 1.4 FANTOM5 ENCODE 1.6 -350.1 -350064 5.6 PKNOX1 WRNIP1 ARID4B SIN3A ZNF2 ZNF143 FOS SP3 NFYC REST ENSG00000204620 PQBP1 PIM2 OTUD5 WAS ENSG00000228343 TBC1D25 GRIPAP1 PPP1R3F ENSG00000279155
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPP1R3F on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R3F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001489905 -28 3200 HDGF PKNOX1 ATF1 SIN3A BRCA1 ZNF2 YY1 GLIS2 ZNF143 FOS

Genomic Location for PPP1R3F Gene

Chromosome:
X
Start:
49,269,829 bp from pter
End:
49,301,461 bp from pter
Size:
31,633 bases
Orientation:
Plus strand

Genomic View for PPP1R3F Gene

Genes around PPP1R3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R3F Gene

Proteins for PPP1R3F Gene

  • Protein details for PPP1R3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSY5-PPR3F_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3F
    Protein Accession:
    Q6ZSY5
    Secondary Accessions:
    • A2VDJ8
    • B3KPW2
    • E9PCM3

    Protein attributes for PPP1R3F Gene

    Size:
    799 amino acids
    Molecular mass:
    82798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG51824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R3F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R3F Gene

Post-translational modifications for PPP1R3F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R3F Gene

Domains & Families for PPP1R3F Gene

Gene Families for PPP1R3F Gene

Protein Domains for PPP1R3F Gene

Suggested Antigen Peptide Sequences for PPP1R3F Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZSY5

UniProtKB/Swiss-Prot:

PPR3F_HUMAN :
  • Contains 1 CBM21 (carbohydrate binding type-21) domain.
Domain:
  • Contains 1 CBM21 (carbohydrate binding type-21) domain.
genes like me logo Genes that share domains with PPP1R3F: view

Function for PPP1R3F Gene

Molecular function for PPP1R3F Gene

UniProtKB/Swiss-Prot Function:
Glycogen-targeting subunit for protein phosphatase 1 (PP1).

Gene Ontology (GO) - Molecular Function for PPP1R3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019903 protein phosphatase binding IPI 21668450
GO:2001069 glycogen binding IDA 21668450
genes like me logo Genes that share ontologies with PPP1R3F: view
genes like me logo Genes that share phenotypes with PPP1R3F: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R3F Gene

Localization for PPP1R3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R3F Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R3F gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPP1R3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 21668450
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PPP1R3F: view

Pathways & Interactions for PPP1R3F Gene

genes like me logo Genes that share pathways with PPP1R3F: view

Pathways by source for PPP1R3F Gene

Gene Ontology (GO) - Biological Process for PPP1R3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005979 regulation of glycogen biosynthetic process IDA 21668450
GO:2000465 regulation of glycogen (starch) synthase activity IDA 21668450
genes like me logo Genes that share ontologies with PPP1R3F: view

No data available for SIGNOR curated interactions for PPP1R3F Gene

Transcripts for PPP1R3F Gene

Unigene Clusters for PPP1R3F Gene

Protein phosphatase 1, regulatory subunit 3F:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3F Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for PPP1R3F Gene

GeneLoc Exon Structure for
PPP1R3F
ECgene alternative splicing isoforms for
PPP1R3F

Expression for PPP1R3F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R3F Gene

Protein differential expression in normal tissues from HIPED for PPP1R3F Gene

This gene is overexpressed in Frontal cortex (39.1), Retina (23.5), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R3F Gene



Protein tissue co-expression partners for PPP1R3F Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R3F Gene:

PPP1R3F

SOURCE GeneReport for Unigene cluster for PPP1R3F Gene:

Hs.433652

mRNA Expression by UniProt/SwissProt for PPP1R3F Gene:

Q6ZSY5-PPR3F_HUMAN
Tissue specificity: Expressed in brain, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with PPP1R3F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP1R3F Gene

Orthologs for PPP1R3F Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R3F Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PPP1R3F 34 35
  • 90.72 (n)
cow
(Bos Taurus)
Mammalia PPP1R3F 34 35
  • 88.23 (n)
mouse
(Mus musculus)
Mammalia Ppp1r3f 34 16 35
  • 84.67 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP1R3F 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R3F 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R3F 35
  • 25 (a)
OneToOne
Species where no ortholog for PPP1R3F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPP1R3F Gene

ENSEMBL:
Gene Tree for PPP1R3F (if available)
TreeFam:
Gene Tree for PPP1R3F (if available)

Paralogs for PPP1R3F Gene

No data available for Paralogs for PPP1R3F Gene

Variants for PPP1R3F Gene

Sequence variations from dbSNP and Humsavar for PPP1R3F Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1028276 -- 49,276,522(+) aaagg(A/C)aatag intron-variant, utr-variant-5-prime
rs1055983 -- 49,275,397(+) CCCAA(A/C)TAATT intron-variant, utr-variant-5-prime
rs111280430 -- 49,291,542(+) AGGCT(A/G)GTCTC intron-variant
rs111418863 -- 49,286,468(+) AGGGG(A/G)CAGCC intron-variant, reference, missense
rs111505885 -- 49,270,193(+) GTCCC(C/T)GCTGG intron-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PPP1R3F Gene

Variant ID Type Subtype PubMed ID
nsv528292 CNV gain 19592680
nsv471602 CNV gain 15918152
nsv469734 CNV gain+loss 16826518
esv32909 CNV gain+loss 17666407

Variation tolerance for PPP1R3F Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R3F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R3F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R3F Gene

Disorders for PPP1R3F Gene

Relevant External Links for PPP1R3F

Genetic Association Database (GAD)
PPP1R3F
Human Genome Epidemiology (HuGE) Navigator
PPP1R3F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R3F

No disorders were found for PPP1R3F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R3F Gene

Publications for PPP1R3F Gene

  1. R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals. (PMID: 21668450) Kelsall I.R. … Cohen P.T. (J. Neurochem. 2011) 3 4 64
  2. Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk. (PMID: 20398921) Suttner K. … Kabesch M. (J. Allergy Clin. Immunol. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PPP1R3F Gene

Sources for PPP1R3F Gene

Content
Loading form....