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Aliases for PPP1R3F Gene

Aliases for PPP1R3F Gene

  • Protein Phosphatase 1 Regulatory Subunit 3F 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3F 2 3
  • Protein Phosphatase 1, Regulatory Subunit 3F 2 3
  • R3F 3 4
  • HB2E 3

External Ids for PPP1R3F Gene

Previous GeneCards Identifiers for PPP1R3F Gene

  • GC0XP047907
  • GC0XP047365
  • GC0XP048152
  • GC0XP048882
  • GC0XP049013
  • GC0XP049126
  • GC0XP046782

Summaries for PPP1R3F Gene

Entrez Gene Summary for PPP1R3F Gene

  • This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PPP1R3F Gene

PPP1R3F (Protein Phosphatase 1 Regulatory Subunit 3F) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. GO annotations related to this gene include protein phosphatase binding and glycogen binding.

UniProtKB/Swiss-Prot for PPP1R3F Gene

  • Glycogen-targeting subunit for protein phosphatase 1 (PP1).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3F Gene

Genomics for PPP1R3F Gene

Regulatory Elements for PPP1R3F Gene

Enhancers for PPP1R3F Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPP1R3F on UCSC Golden Path with GeneCards custom track

Promoters for PPP1R3F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R3F on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPP1R3F gene promoter:

Genomic Location for PPP1R3F Gene

49,269,829 bp from pter
49,301,461 bp from pter
31,633 bases
Plus strand

Genomic View for PPP1R3F Gene

Genes around PPP1R3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R3F Gene

Proteins for PPP1R3F Gene

  • Protein details for PPP1R3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3F
    Protein Accession:
    Secondary Accessions:
    • A2VDJ8
    • B3KPW2
    • E9PCM3

    Protein attributes for PPP1R3F Gene

    799 amino acids
    Molecular mass:
    82798 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI31589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG51824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R3F Gene


neXtProt entry for PPP1R3F Gene

Proteomics data for PPP1R3F Gene at MOPED

Post-translational modifications for PPP1R3F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R3F Gene

No data available for DME Specific Peptides for PPP1R3F Gene

Domains & Families for PPP1R3F Gene

Gene Families for PPP1R3F Gene

Protein Domains for PPP1R3F Gene

Suggested Antigen Peptide Sequences for PPP1R3F Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CBM21 (carbohydrate binding type-21) domain.
  • Contains 1 CBM21 (carbohydrate binding type-21) domain.
genes like me logo Genes that share domains with PPP1R3F: view

Function for PPP1R3F Gene

Molecular function for PPP1R3F Gene

UniProtKB/Swiss-Prot Function:
Glycogen-targeting subunit for protein phosphatase 1 (PP1).
genes like me logo Genes that share phenotypes with PPP1R3F: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R3F Gene

Localization for PPP1R3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R3F Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PPP1R3F Gene COMPARTMENTS Subcellular localization image for PPP1R3F gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PPP1R3F Gene

Pathways & Interactions for PPP1R3F Gene

genes like me logo Genes that share pathways with PPP1R3F: view

Pathways by source for PPP1R3F Gene

Interacting Proteins for PPP1R3F Gene

Gene Ontology (GO) - Biological Process for PPP1R3F Gene


No data available for SIGNOR curated interactions for PPP1R3F Gene

Drugs & Compounds for PPP1R3F Gene

No Compound Related Data Available

Transcripts for PPP1R3F Gene

Unigene Clusters for PPP1R3F Gene

Protein phosphatase 1, regulatory subunit 3F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3F Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP4: -

Relevant External Links for PPP1R3F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R3F Gene

mRNA expression in normal human tissues for PPP1R3F Gene

Protein differential expression in normal tissues from HIPED for PPP1R3F Gene

This gene is overexpressed in Frontal cortex (39.1), Retina (23.5), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPP1R3F Gene

SOURCE GeneReport for Unigene cluster for PPP1R3F Gene Hs.433652

mRNA Expression by UniProt/SwissProt for PPP1R3F Gene

Tissue specificity: Expressed in brain, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with PPP1R3F: view

Protein tissue co-expression partners for PPP1R3F Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPP1R3F Gene

Orthologs for PPP1R3F Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R3F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R3F 35
  • 88.23 (n)
  • 85.19 (a)
PPP1R3F 36
  • 85 (a)
(Canis familiaris)
Mammalia PPP1R3F 35
  • 90.72 (n)
  • 88.54 (a)
PPP1R3F 36
  • 89 (a)
(Mus musculus)
Mammalia Ppp1r3f 35
  • 84.67 (n)
  • 81.37 (a)
Ppp1r3f 16
Ppp1r3f 36
  • 81 (a)
(Monodelphis domestica)
Mammalia PPP1R3F 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R3F 36
  • 35 (a)
(Anolis carolinensis)
Reptilia PPP1R3F 36
  • 25 (a)
Species with no ortholog for PPP1R3F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPP1R3F Gene

Gene Tree for PPP1R3F (if available)
Gene Tree for PPP1R3F (if available)

Paralogs for PPP1R3F Gene

No data available for Paralogs for PPP1R3F Gene

Variants for PPP1R3F Gene

Sequence variations from dbSNP and Humsavar for PPP1R3F Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs17148347 - 49,281,453(+) CACCT(C/T)TGCCA reference, missense
rs1028276 -- 49,276,522(+) aaagg(A/C)aatag intron-variant
rs1055983 -- 49,275,397(+) CCCAA(A/C)TAATT intron-variant
rs2037973 -- 49,274,839(+) ACTTG(C/T)GGCCC intron-variant
rs2091977 -- 49,281,017(+) GAGTA(C/G/T)TAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R3F Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv469734 CNV Complex 16826518
nsv471602 CNV Gain 15918152

Variation tolerance for PPP1R3F Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPP1R3F Gene

Disorders for PPP1R3F Gene

Relevant External Links for PPP1R3F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPP1R3F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R3F Gene

Publications for PPP1R3F Gene

  1. R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals. (PMID: 21668450) Kelsall I.R. … Cohen P.T. (J. Neurochem. 2011) 3 4 67
  2. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. (PMID: 20479760) Piton A. … Rouleau G.A. (Mol. Psychiatry 2011) 3

Products for PPP1R3F Gene

Sources for PPP1R3F Gene