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PPP1R3C Gene

protein-coding   GIFtS: 65
GCID: GC10M093378

Protein Phosphatase 1, Regulatory Subunit 3C

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 3C)
(Previous symbol: PPP1R5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Phosphatase 1, Regulatory Subunit 3C1 2     PP1 Subunit R52 3
PPP1R51 2 3 5     Phosphatase 11
Protein Targeting To Glycogen1 2 3     Regulatory Inhibitor Subunit 51
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3C1 2     Phosphatase 1, Regulatory Inhibitor Subunit 52
Protein Phosphatase 1 Regulatory Subunit 52 3     Protein Phosphatase 1 Regulatory Subunit 3C2
PTG2 3     

External Ids:    HGNC: 92931   Entrez Gene: 55072   Ensembl: ENSG000001199387   OMIM: 6029995   UniProtKB: Q9UQK13   

Export aliases for PPP1R3C gene to outside databases

Previous GC identifers: GC10M092269 GC10M092609 GC10M093519 GC10M093052 GC10M093036 GC10M087016


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPP1R3C Gene:
This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein
phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing,
protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different
regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to
extracellular signals. (provided by RefSeq, Oct 2011)

GeneCards Summary for PPP1R3C Gene:
PPP1R3C (protein phosphatase 1, regulatory subunit 3C) is a protein-coding gene. Diseases associated with PPP1R3C include lafora disease, and myoclonus epilepsy. GO annotations related to this gene include protein phosphatase binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP1R3G.

UniProtKB/Swiss-Prot: PPR3C_HUMAN, Q9UQK1
Function: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase,
reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and
insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types

Gene Wiki entry for PPP1R3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPP1R3C gene promoter:
         FOXI1   AML1a   Pax-5   GCNF   GCNF-1   Hand1   ZIC2/Zic2   E4BP4   GCNF-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPP1R3C promoter sequence
   Search Chromatin IP Primers for PPP1R3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPP1R3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24   Ensembl cytogenetic band:  10q23.32   HGNC cytogenetic band: 10q23-q24

PPP1R3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R3C gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M093378:  view genomic region     (about GC identifiers)

Start:
93,388,199 bp from pter      End:
93,392,858 bp from pter
Size:
4,660 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PPR3C_HUMAN, Q9UQK1 (See protein sequence)
Recommended Name: Protein phosphatase 1 regulatory subunit 3C  
Size: 317 amino acids; 36445 Da
Subunit: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with
glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1
activity. Also interacts with EPM2A/laforin
Sequence caution: Sequence=AAD33215.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R7X0 O95686

Explore the universe of human proteins at neXtProt for PPP1R3C: NX_Q9UQK1

Explore proteomics data for PPP1R3C at MOPED

Post-translational modifications: 

  • Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPP1R3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005389.1  
    ENSEMBL proteins: 
     ENSP00000238994  
    Reactome Protein details: Q9UQK1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    2 InterPro protein domains:
     IPR017434 Pase-1_Glycogen_target-su_met
     IPR005036 CBM_21

    Graphical View of Domain Structure for InterPro Entry Q9UQK1

    ProtoNet protein and cluster: Q9UQK1

    1 Blocks protein domain: IPB005036 Putative phosphatase regulatory subunit

    UniProtKB/Swiss-Prot: PPR3C_HUMAN, Q9UQK1
    Domain: The N-terminal region is required for binding to PP1, the central region is required for binding to
    glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and
    phosphorylase kinase (By similarity)
    Similarity: Contains 1 CBM21 (carbohydrate binding type-21) domain


    PPP1R3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPR3C_HUMAN, Q9UQK1
    Function: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase,
    reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and
    insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity TAS8985175
    GO:0005515protein binding IPI14532330
    GO:0019903protein phosphatase binding IEA--
         
    PPP1R3C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PPP1R3C:
     Decreased focal adhesion (FA)  

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppp1r3c):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    PPP1R3C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppp1r3ctm1Ars for PPP1R3C

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    8 qRT-PCR Assays for microRNAs that regulate PPP1R3C:
    hsa-miR-548t hsa-miR-595 hsa-miR-502-5p hsa-miR-16-2* hsa-miR-195* hsa-miR-1252 hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPP1R3C 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    PPP1R3C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPP1R3C About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37
    Insulin Receptor Pathway0.37
    Erythropoietin Pathway0.37
    CDK5 Pathway0.36
    3Glucose metabolism
    Glucose metabolism0.44
    Glycogen synthesis0.00
    4PEDF Induced Signaling
    IL-6 Pathway0.61
    5ERK Signaling
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPP1R3C (see all 14)
        Activation of PKA through GPCR
    PKA Signaling
    eIF2 Pathway
    CDK5 Pathway
    Breast Cancer Regulation by Stathmin1

    1 Tocris Bioscience Pathway for PPP1R3C
        Insulin Pathway

    1 BioSystems Pathway for PPP1R3C
        Diurnally regulated genes with circadian orthologs

    2 Reactome Pathways for PPP1R3C
        Glycogen synthesis
    Myoclonic epilepsy of Lafora


    1 Kegg Pathway  (Kegg details for PPP1R3C):
        Insulin signaling pathway


    PPP1R3C for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPP1R3C
    Interactions:

        GeneGlobe Interaction Network for PPP1R3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPP1R3C (Q9UQK11, 2, 3 ENSP000002389944) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPM2AO952781, 3, ENSP000003564894EBI-2506727,EBI-2506661 I2D: score=2 STRING: ENSP00000356489
    SGTAO437652, 3, ENSP000002215664MINT-8267118 I2D: score=2 STRING: ENSP00000221566
    NHLRC1Q6VVB13, ENSP000003454644I2D: score=1 STRING: ENSP00000345464
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AKT1ENSP000002702024STRING: ENSP00000270202
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005977glycogen metabolic process ----
    GO:0005978glycogen biosynthetic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0016311dephosphorylation TAS8985175

    PPP1R3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPP1R3C (PPR3C)

    1 HMDB Compound for PPP1R3C    About this table
    CompoundSynonyms CAS #PubMed Ids
    GlycogenAnimal starch (see all 5)9005-79-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPP1R3C gene: 
    NM_005398.5  

    Unigene Cluster for PPP1R3C:

    Protein phosphatase 1, regulatory subunit 3C
    Hs.303090  [show with all ESTs]
    Unigene Representative Sequence: BX537399
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000238994(uc001kho.3)

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    hsa-miR-548t hsa-miR-595 hsa-miR-502-5p hsa-miR-16-2* hsa-miR-195* hsa-miR-1252 hsa-miR-513c hsa-miR-514b-5p
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    Additional mRNA sequence: 

    AK299392.1 AK299398.1 AK313149.1 BC012625.1 BX537399.1 Y18207.1 

    4 DOTS entries:

    DT.452058  DT.75114877  DT.121239546  DT.97814683 

    Selected AceView cDNA sequences (see all 173):

    AL598584 BE858634 AA758923 AI754095 BU619571 BP341518 R83485 BU175770 
    BP342430 BQ772126 BF446256 AA043030 BF057434 AW052132 Z42059 CA426840 
    AA193206 BE549838 AA375845 BP373545 CB055169 AA248916 CA454283 BQ878820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPP1R3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAAAAGT
    PPP1R3C Expression
    About this image


    PPP1R3C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Collecting Duct Cells Renal Collecting Duct System
             Metanephros
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Perivascular Adipose
             HyStem+BMP4-induced E15 cells
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
             Detroit 551
     
     Epithelial Cells
             Collecting Duct Cells Renal Collecting Duct System
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Bulge Stem Cells Bulge
    PPP1R3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPP1R3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.303090
        Custom PCR Arrays for PPP1R3C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPP1R3C gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppp1r3c1 , 5 protein phosphatase 1, regulatory (inhibitor) subunit more1, 5 86.12(n)1
    86.12(a)1
      19 (31.89 cM)5
    534121  NM_016854.21  NP_058550.11 
     367317315 
    chicken
    (Gallus gallus)
    Aves PPP1R3C1 protein phosphatase 1, regulatory subunit 3C 69.46(n)
    65.16(a)
      425328  XM_423102.3  XP_423102.2 
    lizard
    (Anolis carolinensis)
    Reptilia PPP1R3C6
    protein phosphatase 1, regulatory subunit 3C
    66(a)
    1 ↔ 1
    GL343219.1(1054807-1055769)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142552 Xenopus laevis transcribed sequence with weak similarity more 71.13(n)    BX847900.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732592 hypothetical protein MGC73259 72.13(n)   393807  BC060926.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92383 protein phosphatase 1 binding 42(a)   70E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea H18N23.26
    Protein H18N23.2, isoform b
    19(a)
    1 → many
    X(17622778-17640743) WBGene00019211


    ENSEMBL Gene Tree for PPP1R3C (if available)
    TreeFam Gene Tree for PPP1R3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPP1R3C gene
    PPP1R3G2  PPP1R3A2  PPP1R3B2  PPP1R3E2  PPP1R3D2  
    1 SIMAP similar gene for PPP1R3C using alignment to 1 protein entry:     PPR3C_HUMAN:
    PPP1R3B

    PPP1R3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PPP1R3C (see all 167)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741492811,2
    C,F--93387735(+) CAGTGC/ATGCTC 1 -- int12Minor allele frequency- A:0.03WA 120
    rs1898120501,2
    --93387765(+) GCCTAA/CTGCCC 1 -- int10--------
    rs43828141,2
    C,F,H--93387851(+) CTCCAA/GCCTTT 1 -- int18Minor allele frequency- G:0.13NS EA WA CSA NA 658
    rs733220171,2
    C,F--93387897(+) CATGGC/TCTCCA 1 -- int13Minor allele frequency- T:0.06WA CSA 122
    rs733220191,2
    C,F--93387939(+) GTGAGC/GAGAAA 1 -- int12Minor allele frequency- G:0.07WA 120
    rs1810787101,2
    --93387952(+) ATAGAG/TGAGGA 1 -- int10--------
    rs1996591861,2
    C--93388060(+) AGACT-/GGGGCC 1 -- int10--------
    rs746100541,2
    F--93388116(+) CTGCTC/TAGTTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1149810901,2
    C,F--93388130(+) CTAAAT/CGAAAA 1 -- int11Minor allele frequency- C:0.07WA 118
    rs1163484081,2
    C,F--93388131(+) TAAATG/AAAAAA 1 -- int11Minor allele frequency- A:0.06WA 118

    HapMap Linkage Disequilibrium report for PPP1R3C (93388199 - 93392858 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PPP1R3C: --
    Human Gene Mutation Database (HGMD): PPP1R3C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPP1R3C
    DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602999    OMIM disorders: --

    9 diseases for PPP1R3C:    
    About MalaCards
    lafora disease    myoclonus epilepsy    progressive myoclonus epilepsy    myoclonus
    hypoxia    sinusitis    alzheimer's disease    neuronitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for PPP1R3C:
    Progressive myoclonus epilepsy

    PPP1R3C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PPP1R3C
    Human Genome Epidemiology (HuGE) Navigator: PPP1R3C (1 document)

    Export disorders for PPP1R3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPP1R3C gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with PPP1R3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1. (PubMed id 8985175)1, 2, 3 Doherty M.J.... Cohen P.T.W. (FEBS Lett. 1996)
    2. A PTG variant contributes to a milder phenotype in Lafora disease. (PubMed id 21738631)1, 2 Guerrero R.... Gomez-Garre P. (PLoS ONE 2011)
    3. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). (PubMed id 18070875)1, 2 Worby C.A.... Dixon J.E. (J. Biol. Chem. 2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. (PubMed id 14532330)1, 2 Fernandez-Sanchez M.E.... Rodriguez de Cordoba S. (Hum. Mol. Genet. 2003)
    6. Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians. (PubMed id 10222257)1, 2 Permana P.A.... Bogardus C. (Biochem. Biophys. Res. Commun. 1999)
    7. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
    8. Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329. (PubMed id 23922729)1 SA!nchez-MartA-n P....RomA!-Mateo C. (PLoS ONE 2013)
    9. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5507 HGNC: 9293 AceView: PPP1R3C Ensembl:ENSG00000119938 euGenes: HUgn5507
    ECgene: PPP1R3C Kegg: 5507 H-InvDB: PPP1R3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPP1R3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPP1R3C gene:
    Search GeneIP for patents involving PPP1R3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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