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Aliases for PPP1R3B Gene

Aliases for PPP1R3B Gene

  • Protein Phosphatase 1 Regulatory Subunit 3B 2 3 5
  • PP1 Subunit R4 2 3 4
  • Hepatic Glycogen-Targeting Protein Phosphatase 1 Regulatory Subunit GL 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3B 2 3
  • Protein Phosphatase 1, Regulatory Subunit 3B 2 3
  • Protein Phosphatase 1 Regulatory Subunit 4 3 4
  • PPP1R4 3 4
  • PTG 3 4
  • Hepatic Glycogen-Targeting Subunit, G(L) 3
  • Hepatic Glycogen-Targeting Subunit 2
  • Protein Phosphatase 1 Subunit GL 4
  • G(L) 2
  • GL 3

External Ids for PPP1R3B Gene

Previous GeneCards Identifiers for PPP1R3B Gene

  • GC08M008912
  • GC08M009032
  • GC08M007918
  • GC08M008993

Summaries for PPP1R3B Gene

Entrez Gene Summary for PPP1R3B Gene

  • This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

GeneCards Summary for PPP1R3B Gene

PPP1R3B (Protein Phosphatase 1 Regulatory Subunit 3B) is a Protein Coding gene. Diseases associated with PPP1R3B include barre-lieou syndrome and water-clear cell adenoma. Among its related pathways are Beta-Adrenergic Signaling and Translation Insulin regulation of translation. GO annotations related to this gene include enzyme binding and protein phosphatase regulator activity. An important paralog of this gene is PPP1R3E.

UniProtKB/Swiss-Prot for PPP1R3B Gene

  • Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3B Gene

Genomics for PPP1R3B Gene

Regulatory Elements for PPP1R3B Gene

Promoters for PPP1R3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPP1R3B on UCSC Golden Path with GeneCards custom track

Genomic Location for PPP1R3B Gene

Chromosome:
8
Start:
9,136,254 bp from pter
End:
9,151,642 bp from pter
Size:
15,389 bases
Orientation:
Minus strand

Genomic View for PPP1R3B Gene

Genes around PPP1R3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R3B Gene

Proteins for PPP1R3B Gene

  • Protein details for PPP1R3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XI6-PPR3B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3B
    Protein Accession:
    Q86XI6
    Secondary Accessions:
    • B3KTV3
    • Q9H812

    Protein attributes for PPP1R3B Gene

    Size:
    285 amino acids
    Molecular mass:
    32695 Da
    Quaternary structure:
    • Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for PPP1R3B Gene

neXtProt entry for PPP1R3B Gene

Proteomics data for PPP1R3B Gene at MOPED

Post-translational modifications for PPP1R3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R3B Gene

Domains & Families for PPP1R3B Gene

Gene Families for PPP1R3B Gene

Protein Domains for PPP1R3B Gene

Suggested Antigen Peptide Sequences for PPP1R3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XI6

UniProtKB/Swiss-Prot:

PPR3B_HUMAN :
  • The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.
Domain:
  • The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.
  • Contains 1 CBM21 (carbohydrate binding type-21) domain.
genes like me logo Genes that share domains with PPP1R3B: view

Function for PPP1R3B Gene

Molecular function for PPP1R3B Gene

UniProtKB/Swiss-Prot Function:
Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).

Gene Ontology (GO) - Molecular Function for PPP1R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with PPP1R3B: view
genes like me logo Genes that share phenotypes with PPP1R3B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R3B Gene

Localization for PPP1R3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPP1R3B Gene COMPARTMENTS Subcellular localization image for PPP1R3B gene
Compartment Confidence
cytosol 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PPP1R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
genes like me logo Genes that share ontologies with PPP1R3B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R3B Gene

Pathways & Interactions for PPP1R3B Gene

genes like me logo Genes that share pathways with PPP1R3B: view

Pathways by source for PPP1R3B Gene

Interacting Proteins for PPP1R3B Gene

Gene Ontology (GO) - Biological Process for PPP1R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IEA --
GO:0005981 regulation of glycogen catabolic process IDA 22225877
genes like me logo Genes that share ontologies with PPP1R3B: view

No data available for SIGNOR curated interactions for PPP1R3B Gene

Drugs & Compounds for PPP1R3B Gene

(1) Additional Compounds for PPP1R3B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
genes like me logo Genes that share compounds with PPP1R3B: view

Transcripts for PPP1R3B Gene

mRNA/cDNA for PPP1R3B Gene

Unigene Clusters for PPP1R3B Gene

Protein phosphatase 1, regulatory subunit 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3B Gene

No ASD Table

Relevant External Links for PPP1R3B Gene

GeneLoc Exon Structure for
PPP1R3B
ECgene alternative splicing isoforms for
PPP1R3B

Expression for PPP1R3B Gene

mRNA expression in normal human tissues for PPP1R3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R3B Gene

This gene is overexpressed in Whole Blood (x6.0) and Muscle - Skeletal (x4.2).

SOURCE GeneReport for Unigene cluster for PPP1R3B Gene Hs.458513

mRNA Expression by UniProt/SwissProt for PPP1R3B Gene

Q86XI6-PPR3B_HUMAN
Tissue specificity: Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung.
genes like me logo Genes that share expression patterns with PPP1R3B: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PPP1R3B Gene

Orthologs for PPP1R3B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R3B 36
  • 99 (a)
OneToOne
PPP1R3B 35
  • 99.65 (n)
  • 99.3 (a)
cow
(Bos Taurus)
Mammalia PPP1R3B 35
  • 86.27 (n)
  • 89.79 (a)
PPP1R3B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R3B 36
  • 84 (a)
OneToOne
PPP1R3B 35
  • 85.73 (n)
  • 89.82 (a)
mouse
(Mus musculus)
Mammalia Ppp1r3b 16
Ppp1r3b 36
  • 90 (a)
OneToOne
Ppp1r3b 35
  • 86.27 (n)
  • 89.79 (a)
oppossum
(Monodelphis domestica)
Mammalia PPP1R3B 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ppp1r3b 35
  • 85.21 (n)
  • 89.79 (a)
chicken
(Gallus gallus)
Aves PPP1R3B 35
  • 71.97 (n)
  • 71.73 (a)
PPP1R3B 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R3B 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r3b 35
  • 62.98 (n)
  • 62.86 (a)
zebrafish
(Danio rerio)
Actinopterygii ppp1r3b 36
  • 51 (a)
OneToOne
Dr.4453 35
ppp1r3b 35
  • 58.67 (n)
  • 56.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9238 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H18N23.2 35
  • 43.26 (n)
  • 34.67 (a)
H18N23.2 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for PPP1R3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R3B Gene

ENSEMBL:
Gene Tree for PPP1R3B (if available)
TreeFam:
Gene Tree for PPP1R3B (if available)

Paralogs for PPP1R3B Gene

Paralogs for PPP1R3B Gene

(1) SIMAP similar genes for PPP1R3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPP1R3B: view

Variants for PPP1R3B Gene

Sequence variations from dbSNP and Humsavar for PPP1R3B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3748140 - 9,141,509(-) CAGTG(A/G)AATGG reference, missense
rs330905 -- 9,136,041(-) ACCCA(A/T)TTTTA downstream-variant-500B
rs330908 -- 9,137,656(-) CCACT(C/T)GCTCC utr-variant-3-prime
rs330909 -- 9,137,877(-) CACCC(A/C/G/T)GGCTT utr-variant-3-prime
rs330910 -- 9,138,245(-) GGGTA(A/T)CAGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPP1R3B Gene

Variant ID Type Subtype PubMed ID
nsv824529 CNV Gain 20364138
nsv436801 CNV Insertion 17901297
esv2660363 CNV Deletion 23128226
esv2736571 CNV Deletion 23290073

Variation tolerance for PPP1R3B Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPP1R3B Gene

HapMap Linkage Disequilibrium report
PPP1R3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R3B Gene

Disorders for PPP1R3B Gene

MalaCards: The human disease database

(3) MalaCards diseases for PPP1R3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
barre-lieou syndrome
  • cervicocranial syndrome
water-clear cell adenoma
maturity-onset diabetes of the young
  • mason-type diabetes
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPP1R3B

Genetic Association Database (GAD)
PPP1R3B
Human Genome Epidemiology (HuGE) Navigator
PPP1R3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPP1R3B
genes like me logo Genes that share disorders with PPP1R3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R3B Gene

Publications for PPP1R3B Gene

  1. Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle. (PMID: 17555403) Montori-Grau M. … Gomez-Foix A.M. (Biochem. J. 2007) 2 3 4 23 67
  2. Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. (PMID: 16907705) Dunn J.S. … Doria A. (Ann. Hum. Genet. 2006) 3 23
  3. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H. … Bollen M. (Bioessays 2002) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3

Products for PPP1R3B Gene

Sources for PPP1R3B Gene

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