Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPP1R3B Gene

protein-coding GIFtS: 55
GCID: GC08M009032

protein phosphatase 1, regulatory subunit 3B

(Previous names: protein phosphatase 1, regulatory (inhibitor) subunit 3B...)

Explore 3 diseases affiliated with
PPP1R3B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Phosphatase 1, Regulatory Subunit 3B¹ ²		PTG² ³
PPP1R4¹ ² ³		PP1 Subunit R4² ³
GL¹ ²		FLJ14005¹
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3B¹ ²		Hepatic Glycogen-Targeting Subunit, G(L)²
Hepatic Glycogen-Targeting Protein Phosphatase 1 Regulatory Subunit GL² ³		Protein Phosphatase 1 Regulatory Subunit 3B²
Protein Phosphatase 1 Regulatory Subunit 4² ³		Protein Phosphatase 1 Subunit GL³

External Ids:	HGNC: 14942¹	Entrez Gene: 79660²	Ensembl: ENSG00000173281⁷	OMIM: 610541⁵	UniProtKB: Q86XI6³

Export aliases for PPP1R3B gene to outside databases

Previous GC identifers: GC08M008912 GC08M007918

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPP1R3B:

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein

is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these

tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing

results in multiple transcript variants that encode the same protein.(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: PPR3B_HUMAN, Q86XI6

Function: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of

the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates)

glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen

breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen

phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis

upon overexpression in hepatocytes (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_077531.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPP1R3B gene promoter:
USF1 AML1a MyoD USF2 XBP-1 USF-1:USF-2 USF-1 Sox9 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPP1R3B promoter sequence

Search SABiosciences Chromatin IP Primers for PPP1R3B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R3B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

PPP1R3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPP1R3B gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M009032: view genomic region (about GC identifiers)

Start:	8,993,765 bp from pter	End:	9,009,084 bp from pter
Size:	15,320 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPR3B_HUMAN, Q86XI6 (See protein sequence)

Recommended Name: Protein phosphatase 1 regulatory subunit 3B

Size: 285 amino acids; 32695 Da

Subunit: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms

complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is

necessary for its regulation of PP1 activity (By similarity)

1 PDB 3D structure from and Proteopedia for PPP1R3B:

2EEF (3D)

Secondary accessions: B3KTV3 Q9H812

Explore the universe of human proteins at neXtProt for PPP1R3B: NX_Q86XI6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86XI6

PPP1R3B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001188258.1 NP_078883.2

ENSEMBL proteins:

ENSP00000308318 ENSP00000428642

Human Recombinant Protein Products for PPP1R3B:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PPP1R3B OriGene Custom Protein Services for PPP1R3B
	GenScript Custom Purified and Recombinant Proteins Services for PPP1R3B
	Novus Biologicals PPP1R3B Protein Novus Biologicals PPP1R3B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PPP1R3B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000164	protein phosphatase type 1 complex	IEA	--
GO:0042587	glycogen granule	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IEA	--

PPP1R3B for ontologies About GeneDecksing

PPP1R3B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PPP1R3B
	GenScript Custom Superior Antibodies Services for PPP1R3B
	Novus Biologicals PPP1R3B Antibodies
	Abcam antibodies for PPP1R3B
	Uscn Antibodies for PPP1R3B
	Search ThermoFisher Antibodies for PPP1R3B

Assay Products for PPP1R3B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PPP1R3B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PPP1R3B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPP1R3B for domains About GeneDecksing

2 InterPro domains/families:

IPR017434 Pase-1_Glycogen_target-su_met

IPR005036 CBM_21

Graphical View of Domain Structure for InterPro Entry Q86XI6

ProtoNet protein and cluster: Q86XI6

1 Blocks protein family: IPB005036 Putative phosphatase regulatory subunit

UniProtKB/Swiss-Prot: PPR3B_HUMAN, Q86XI6

Domain: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen

and the C-terminal region is required for binding to PYGL (By similarity)

Similarity: Contains 1 CBM21 (carbohydrate binding type-21) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PPR3B_HUMAN, Q86XI6

Function: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of

the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates)

glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen

breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen

phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis

upon overexpression in hepatocytes (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019888	protein phosphatase regulator activity	IEA	--
GO:0019899	enzyme binding	IEA	--

PPP1R3B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PPP1R3B:

Upregulation of NF-kappaB path

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ppp1r3b):

behavior/neurological

growth/size

homeostasis/metabolism

reproductive system

PPP1R3B for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PPP1R3B

miRNA Products:		OriGene 3'-UTR Clone: PPP1R3B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R3B
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R3B (see all 54):
		hsa-miR-607 hsa-miR-4328 hsa-miR-106a hsa-miR-548k hsa-miR-513a-5p hsa-miR-3653 hsa-miR-519a hsa-miR-766

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R3B (see all 7) OriGene shRNA RFP: PPP1R3B OriGene siRNA: PPP1R3B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R3B
		Sirion Biotech Custom design and validation of potent shRNA sequences against PPP1R3B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PPP1R3B
			Sirion Biotech Customized adenovirus for overexpression of PPP1R3B Sirion Biotech Customized adenovirus for potent knockdown of PPP1R3B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R3B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R3B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PPP1R3B (NM_024607)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R3B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R3B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPP1R3B
		Search LifeMap BioReagents cell lines for PPP1R3B
		Sirion Biotech Customized stable knockdown cell line services for PPP1R3B Sirion Biotech Customized inducible knockdown cell line services for PPP1R3B Sirion Biotech Customized stable overexpressing cell line services for PPP1R3B Sirion Biotech Customized inducible overexpressing cell line services for PPP1R3B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R3B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Erythropoietin Pathway

	Erythropoietin Pathway	1.00			Insulin Receptor Pathway	0.37
	Beta-Adrenergic Signaling	0.37			CDK5 Pathway	0.21

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Dopamine-DARPP32 Feedback onto cAMP Pathway

Dopamine-DARPP32 Feedback onto cAMP Pathway

1.00

PEDF Induced Signaling

IL-6 Pathway

0.61

Rho Family GTPases

ERK Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPP1R3B (see all 14)

	Activation of PKA through GPCR
	PKA Signaling
	eIF2 Pathway
	CDK5 Pathway
	Breast Cancer Regulation by Stathmin1

1 Tocris Bioscience Pathway for PPP1R3B

Insulin Pathway

1 Kegg Pathway (Kegg details for PPP1R3B):

Insulin signaling pathway

PPP1R3B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PPP1R3B

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/17 Interacting proteins for PPP1R3B (Q86XI6^{2, 3} ENSP00000308318⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1CA	P62136²^,³, ENSP00000326031⁴	MINT-62198 I2D: score=3 STRING: ENSP00000326031
ACSL1	P33121³	I2D: score=1
AKT1	ENSP00000270202⁴	STRING: ENSP00000270202
AKT2	ENSP00000375892⁴	STRING: ENSP00000375892
AKT3	ENSP00000263826⁴	STRING: ENSP00000263826

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005977	glycogen metabolic process	IEA	--
GO:0005979	regulation of glycogen biosynthetic process	IEA	--
GO:0005981	regulation of glycogen catabolic process	IEA	--

PPP1R3B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPP1R3B

1 HMDB Compound for PPP1R3B About this table

Compound	Synonyms	CAS #	PubMed Ids
Glycogen	Animal starch (see all 5)	9005-79-2	--

Search CenterWatch for drugs/clinical trials and news about PPP1R3B / PPR3B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPP1R3B gene (2 alternative transcripts):

NM_001201329.1 NM_024607.3

Unigene Cluster for PPP1R3B:

Protein phosphatase 1, regulatory subunit 3B

Hs.458513 [show with all ESTs]

Unigene Representative Sequence: NM_001201329

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310455(uc003wsn.4 uc003wso.4) ENST00000519699

miRNA Products:		OriGene 3'-UTR Clone: PPP1R3B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPP1R3B
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate PPP1R3B (see all 54):
		hsa-miR-607 hsa-miR-4328 hsa-miR-106a hsa-miR-548k hsa-miR-513a-5p hsa-miR-3653 hsa-miR-519a hsa-miR-766

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R3B (see all 7) OriGene shRNA RFP: PPP1R3B OriGene siRNA: PPP1R3B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R3B
		Sirion Biotech Custom design and validation of potent shRNA sequences against PPP1R3B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R3B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R3B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PPP1R3B (NM_024607)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPP1R3B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R3B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1R3B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PPP1R3B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R3B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R3B

Additional cDNA sequence:

AK024067.1 AK091994.1 AK096119.1 BC043388.1

6 DOTS entries:

DT.95367425 DT.99936413 DT.121494603 DT.444116 DT.439398 DT.97791839

24/137 AceView cDNA sequences (see all 137):

AA969633 AA431594 AI368710 AA708960 BF941948 AW272758 AI686220 AI423148

AW673036 AK091994 BG572055 BC043388 AA196415 N91787 AA653745 AU127605

AI057085 AI560584 N75360 AI925295 BU623729 AJ571847 BG057642 AK096119

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPP1R3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTAAAAGA

About this image

PPP1R3B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

Definitive endoderm-like cells (A scalable, suspensi...)

See PPP1R3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPP1R3B

SOURCE GeneReport for Unigene cluster: Hs.458513

UniProtKB/Swiss-Prot: PPR3B_HUMAN, Q86XI6

Tissue specificity: Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus

lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only

moderate levels in liver and heart. Weak expression in placenta and lung

SABiosciences Custom PCR Arrays for PPP1R3B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1R3B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PPP1R3B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R3B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R3B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R3B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PPP1R3B gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PPP1R3B¹	protein phosphatase 1, regulatory (inhibitor) subunit more	71.85(n) 71.73(a)		422630 XM_420586.3 XP_420586.2
lizard (Anolis carolinensis)	Reptilia	PPP1R3B⁶	--	67(a)	1 ↔ 1	GL343257.1(1254277-1255247)
African clawed frog (Xenopus laevis)	Amphibia	BJ065846.1²	--	71.78(n)		BJ065846.1
zebrafish (Danio rerio)	Actinopterygii	Dr.4453²	Danio rerio cDNA clone MGC55542 IMAGE2642605, complete more	71.71(n)		BC044421.1
fruit fly (Drosophila melanogaster)	Insecta	CG9238¹	CG9238	53.09(n) 44.91(a)		39588 NM_140451.2 NP_648708.2
worm (Caenorhabditis elegans)	Secernentea	H18N23.2¹	Protein H18N23.2	43.26(n) 34.67(a)		181788 NM_171981.2 NP_741956.1

ENSEMBL Gene Tree for PPP1R3B (if available)
TreeFam Gene Tree for PPP1R3B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPP1R3B gene

PPP1R3G² PPP1R3A² PPP1R3E² PPP1R3C² PPP1R3D²

1 SIMAP similar gene for PPP1R3B using alignment to 1 protein entry: PPR3B_HUMAN:

PPP1R3C

PPP1R3B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144705469^1,2		--	8993334(+)	`CCTGAA/GCTTTG`	2	--	ds500¹		0	--	--	--	--
rs62494401^1,2	C	--	8993380(+)	`CTATCC/TGCTAC`	2	--	ds500¹		2		NA	122
rs147894028^1,2		--	8993457(+)	`ATTTAC/TAGTTT`	2	--	ds500¹		0	--	--	--	--
rs193288760^1,2		--	8993499(+)	`CTGTAA/CTTCAA`	2	--	ds500¹		0	--	--	--	--
rs330905^1,2	C,F,O,A,H	--	8993551(-)	`ACCCAT/ATTTTA`	2	--	ds500¹		27		NA NS EA WA	2898
rs9886496^1,2	C,F,H	--	8993569(+)	`AACACT/CAGCTC`	2	--	ds500¹		5		NS EA WA	526
rs185087127^1,2		--	8993583(+)	`TATCTC/GTTCCC`	2	--	ds500¹		0	--	--	--	--
rs190418819^1,2		--	8993592(+)	`CCTAGC/TACTTA`	2	--	ds500¹		0	--	--	--	--
rs181238355^1,2		--	8993829(+)	`CCACAC/TAAAGA`	2	--	ut3¹		0	--	--	--	--
rs186594905^1,2		--	8994054(+)	`CGTCAA/GCAAGA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPP1R3B (8993765 - 9009084 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for PPP1R3B
1 CNV: 22985
15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1R3B

DNA2.0 Custom Variant and Variant Library Synthesis for PPP1R3B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPP1R3B for disorders           About GeneDecksing

OMIM gene information: 610541    OMIM disorders: --

3 diseases for PPP1R3B:    About MalaCards

maturity-onset diabetes of the young hepatitis breast cancer

Human Genome Epidemiology (HuGE) Navigator: PPP1R3B (4 documents)

Export disorders for PPP1R3B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPP1R3B gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with PPP1R3B)

Utopia: connect your pdf to the dynamic
world of online information

Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle. (PubMed id 17555403)^{1, 2, 3, 9} Montori-Grau M.... Gomez-Foix A.M. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver. (PubMed id 11872655)^{1, 2} Munro S.... Cohen P.T. (2002)
Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PubMed id 11948623)^{1, 3} Ceulemans H....Bollen M. (2002)
Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. (PubMed id 16907705)^{1, 9} Dunn J.S....Doria A. (2006)
Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)¹ Inouye M....de Bakker P.I. (2012)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)¹ Manning A.K....Langenberg C. (2012)
Genome-wide association study of Alzheimer's disease. (PubMed id 22832961)¹ Kamboh M.I....Barmada M.M. (2012)
Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)¹ Chambers J.C....Kooner J.S. (2011)
Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)¹ Lettre G....Boerwinkle E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79660	HGNC: 14942	AceView: PPP1R3B	Ensembl:ENSG00000173281	euGenes: HUgn79660
ECgene: PPP1R3B	Kegg: 79660	H-InvDB: PPP1R3B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPP1R3B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PPP1R3B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PPP1R3B gene:
Search GeneIP for patents involving PPP1R3B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for PPP1R3B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPP1R3B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPP1R3B
	OriGene Protein Over-expression Lysate for PPP1R3B		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PPP1R3B		OriGene 3'-UTR Clone for PPP1R3B
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R3B		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPP1R3B
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PPP1R3B		OriGene Custom Protein Services for PPP1R3B
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPP1R3B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPP1R3B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPP1R3B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPP1R3B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPP1R3B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPP1R3B

	GenScript Custom Purified and Recombinant Proteins Services for PPP1R3B		GenScript cDNA clones with any tag delivered in your preferred vector for PPP1R3B
	GenScript Custom Assay Services for PPP1R3B		GenScript Custom Superior Antibodies Services for PPP1R3B
	GenScript Custom overexpressing Cell Line Services for PPP1R3B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PPP1R3B promoter
	Search Chromatin IP Primers for PPP1R3B
	RT² qPCR Primer Assay in human, mouse, rat PPP1R3B
	Search GNC Networks for PPP1R3B
	SABiosciences PCR Arrays including human, mouse, rat PPP1R3B

Search Tocris compounds for PPP1R3B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PPP1R3B antibodies
	PPP1R3B proteins
	PPP1R3B lysates

	Antibodies for PPP1R3B
	See all of Abcam's Antibodies, Kits and Proteins for PPP1R3B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

PPP1R3B Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for PPP1R3B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPP1R3B

	Browse SwitchGear 3'UTR luciferase reporter plasmids for PPP1R3B
	SwitchGear Promoter luciferase reporter plasmids for PPP1R3B

Search ThermoFisher Antibodies for PPP1R3B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPP1R3B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PPP1R3B

Sirion Biotech Customized:

	stable knockdown cell line services for PPP1R3B
	inducible knockdown cell line services for PPP1R3B
	design and validation of potent shRNA sequences against PPP1R3B
	adenovirus for potent knockdown of PPP1R3B
	adenovirus for overexpression of PPP1R3B
	stable overexpressing cell line services for PPP1R3B
	inducible overexpressing cell line services for PPP1R3B

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PPP1R3B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

PPP1R3B Gene

protein phosphatase 1, regulatory subunit 3B

Aliases
for PPP1R3B gene

Summaries
for PPP1R3B gene

Genomic Views
for PPP1R3B gene

Proteins
for PPP1R3B gene

Protein Domains /
Families
for PPP1R3B gene

Function
for PPP1R3B gene

Pathways & Interactions
for PPP1R3B gene

Drugs & Compounds
for PPP1R3B gene

Transcripts
for PPP1R3B gene

Expression
for PPP1R3B gene

Orthologs
for PPP1R3B gene

Paralogs
for PPP1R3B gene

Genomic Variants
for PPP1R3B gene

Disorders / Diseases
for PPP1R3B gene

Publications
for PPP1R3B gene

External Searches for PPP1R3B gene

Genome Databases showing PPP1R3B gene

Other Databases showing PPP1R3B gene

Specialized Databases showing PPP1R3B gene

Intellectual Property
for PPP1R3B gene

Products
for PPP1R3B gene

View Random Gene

Advanced Search

Export list of displayed genes

PPP1R3B Gene

protein phosphatase 1, regulatory subunit 3B

Aliasesfor PPP1R3B gene

Summariesfor PPP1R3B gene

Genomic Viewsfor PPP1R3B gene

Proteinsfor PPP1R3B gene

Protein Domains /Familiesfor PPP1R3B gene

Functionfor PPP1R3B gene

Pathways & Interactionsfor PPP1R3B gene

Drugs & Compoundsfor PPP1R3B gene

Transcriptsfor PPP1R3B gene

Expression for PPP1R3B gene

Orthologsfor PPP1R3B gene

Paralogsfor PPP1R3B gene

Genomic Variantsfor PPP1R3B gene

Disorders / Diseasesfor PPP1R3B gene

Publicationsfor PPP1R3B gene

External Searches for PPP1R3B gene

Genome Databases showing PPP1R3B gene

Other Databases showing PPP1R3B gene

Specialized Databases showing PPP1R3B gene

Intellectual Propertyfor PPP1R3B gene

Productsfor PPP1R3B gene

View Random Gene

Aliases
for PPP1R3B gene

Summaries
for PPP1R3B gene

Genomic Views
for PPP1R3B gene

Proteins
for PPP1R3B gene

Protein Domains /
Families
for PPP1R3B gene

Function
for PPP1R3B gene

Pathways & Interactions
for PPP1R3B gene

Drugs & Compounds
for PPP1R3B gene

Transcripts
for PPP1R3B gene

Expression
for PPP1R3B gene

Orthologs
for PPP1R3B gene

Paralogs
for PPP1R3B gene

Genomic Variants
for PPP1R3B gene

Disorders / Diseases
for PPP1R3B gene

Publications
for PPP1R3B gene

Intellectual Property
for PPP1R3B gene

Products
for PPP1R3B gene